Reduction of covalent binding of aflatoxin B1 to rabbit liver DNA after immunization against this carcinogen
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- The covalent binding of [3H]aflatoxin B1 (AF) to liver DNA was determined, 6 h after oral administration to male rabbits. A Covalent Binding Index, CBI (flmol AF/mol DNA-P)/(mmol AF/kg b. w.) = 8,500 was found. Pretreatment of rabbits with AF coupled to bovine serum albumin in Freund's adjuvant led to the production of AF-directed antibodies. Administration of [3H]AF to such immunized rabbits resulted in a CJH of only 2,500, i.e., the iiDJ{.lUnization provided a protection by a factor of more than 3. Although this is encouraging evidence forThe covalent binding of [3H]aflatoxin B1 (AF) to liver DNA was determined, 6 h after oral administration to male rabbits. A Covalent Binding Index, CBI (flmol AF/mol DNA-P)/(mmol AF/kg b. w.) = 8,500 was found. Pretreatment of rabbits with AF coupled to bovine serum albumin in Freund's adjuvant led to the production of AF-directed antibodies. Administration of [3H]AF to such immunized rabbits resulted in a CJH of only 2,500, i.e., the iiDJ{.lUnization provided a protection by a factor of more than 3. Although this is encouraging evidence for the potential of active immunization against genotoxic carcinogens, a nurober of pointswill have to be clarified, such as the time course for the DNA binding and the question of a possible shift to other target cells.…
Autor(en): | M. Caviezel, A. P. Aeschbach, Werner K. Lutz, C. Schlatter |
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URN: | urn:nbn:de:bvb:20-opus-80116 |
Dokumentart: | Artikel / Aufsatz in einer Zeitschrift |
Institute der Universität: | Medizinische Fakultät / Institut für Pharmakologie und Toxikologie |
Sprache der Veröffentlichung: | Englisch |
Erscheinungsjahr: | 1984 |
Originalveröffentlichung / Quelle: | In: Disease, metabolism and reproduction in the toxic response to drugs and other chemicals : proc. of the Europ. Soc. of Toxicology meeting held in Rome, March 28 - 30, 1983. - Mitarb.: Chambers, Philip L. - Berlin: Springer, 1984 [Archives of toxicology / Supplement] ; 7, p. 249-252. |
Allgemeine fachliche Zuordnung (DDC-Klassifikation): | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
Normierte Schlagworte (GND): | Krebs; DNA |
Freie Schlagwort(e): | Aflatoxin; Cancer prevention; Carcinogen; Covalent binding; DNA; Immunization |
Datum der Freischaltung: | 17.10.2013 |
Lizenz (Deutsch): | Deutsches Urheberrecht |