Refine
Year of publication
Document Type
- Doctoral Thesis (8848)
- Journal article (8246)
- Complete part of issue (703)
- Book article / Book chapter (479)
- Book (218)
- Conference Proceeding (202)
- Preprint (129)
- Review (115)
- Master Thesis (104)
- Working Paper (104)
Language
- English (10717)
- German (8555)
- French (58)
- Multiple languages (22)
- Spanish (22)
- Russian (6)
- Italian (2)
- Portuguese (2)
Keywords
- Würzburg (736)
- Universität (668)
- Wuerzburg (666)
- Wurzburg (659)
- University (608)
- Organische Chemie (135)
- Psychologie (127)
- Anorganische Chemie (124)
- Maus (124)
- Toxikologie (123)
- Medizin (111)
- Signaltransduktion (104)
- inflammation (104)
- apoptosis (101)
- Deutschland (99)
- Genexpression (98)
- Taufliege (92)
- Biochemie (87)
- cancer (82)
- gene expression (81)
- Apoptosis (79)
- MRI (76)
- Chemie (74)
- T-Lymphozyt (73)
- Drosophila (72)
- Tissue Engineering (72)
- depression (71)
- Jahresbericht (70)
- HIV (65)
- Herzinsuffizienz (65)
- boron (64)
- Thrombozyt (62)
- children (62)
- therapy (62)
- Apoptose (60)
- Depression (60)
- NMR-Tomographie (60)
- Biologie (59)
- COVID-19 (58)
- Dendritische Zelle (58)
- Infektionsbiologie (58)
- expression (57)
- oxidative stress (57)
- Molekularbiologie (56)
- Bericht (55)
- Escherichia coli (54)
- Kernspintomografie (54)
- Kind (54)
- Neurobiologie (53)
- Diabetes mellitus (52)
- Molekulargenetik (52)
- breast cancer (52)
- machine learning (52)
- ADHD (51)
- Physiologische Chemie (51)
- Rezension (51)
- multiple myeloma (51)
- Krebs <Medizin> (50)
- Lebensqualität (50)
- Annual Report (49)
- Candida albicans (49)
- Drosophila melanogaster (49)
- Melanom (49)
- Neisseria meningitidis (49)
- Immunologie (48)
- infection (48)
- virtual reality (48)
- Bor (47)
- Herzinfarkt (47)
- Schizophrenie (47)
- Therapie (47)
- Entzündung (46)
- Hadron-Hadron scattering (experiments) (46)
- Simulation (46)
- Staphylococcus aureus (46)
- Aspergillus fumigatus (45)
- Transkriptionsfaktor (45)
- Tumor (45)
- anxiety (45)
- melanoma (45)
- myocardial infarction (45)
- Schlaganfall (44)
- T cells (44)
- Topologischer Isolator (44)
- Universitätsbibliothek (44)
- cytokines (44)
- metabolism (44)
- stroke (44)
- Germany (43)
- Zeitschrift (43)
- multiple sclerosis (43)
- Ackerschmalwand (42)
- Genregulation (42)
- Geschichte (42)
- Ratte (42)
- heart failure (42)
- mice (42)
- remote sensing (42)
- Brustkrebs (41)
- EEG (41)
- Oxidativer Stress (41)
- dendritic cells (41)
- magnetic resonance imaging (41)
- Biomarker (40)
- DNA damage (40)
- PET (40)
- Report (40)
- biomarker (40)
- platelets (40)
- prostate cancer (40)
- quality of life (40)
- signal transduction (40)
- Fluoreszenz (39)
- Rezeptor (39)
- SARS-CoV-2 (39)
- University Library (39)
- Virologie (39)
- Zellkultur (39)
- evolution (39)
- in vitro (39)
- ischemic stroke (39)
- Calcium (38)
- Multiple Sklerose (38)
- Plasmozytom (38)
- Angst (37)
- Evolution (37)
- Serotonin (37)
- Stammzelle (37)
- Strahlentherapie (37)
- climate change (37)
- Chemische Synthese (36)
- China (36)
- Entwicklung (36)
- Immuntherapie (35)
- MRT (35)
- Multiples Myelom (35)
- Spektroskopie (35)
- Zelldifferenzierung (35)
- biodiversity (35)
- fluorescence (35)
- macrophages (35)
- Antikörper (34)
- Chirurgie (34)
- Endothel (34)
- Immunsystem (34)
- brain (34)
- differentiation (34)
- obesity (34)
- Biene (33)
- Einzelhandel (33)
- Jugend (33)
- Nanopartikel (33)
- Quantenpunkt (33)
- Supramolekulare Chemie (33)
- mouse (33)
- schizophrenia (33)
- Arteriosklerose (32)
- Bayern (32)
- DNA (32)
- Deutsch (32)
- Regulation (32)
- Schmerz (32)
- Selbstorganisation (32)
- Stress (32)
- gene (32)
- pain (32)
- phosphorylation (32)
- prognosis (32)
- rat (32)
- Arabidopsis thaliana (31)
- Lernen (31)
- Modellierung (31)
- Molekularstrahlepitaxie (31)
- Proliferation (31)
- Zellzyklus (31)
- diagnosis (31)
- genetics (31)
- heart (31)
- Blut-Hirn-Schranke (30)
- CXCR4 (30)
- Fabry disease (30)
- Herz (30)
- Kinder (30)
- Universität Würzburg (30)
- mortality (30)
- protein (30)
- tissue engineering (30)
- Adipositas (29)
- Aufmerksamkeit (29)
- Genetik (29)
- Leistungsbewertung (29)
- Masernvirus (29)
- Photoelektronenspektroskopie (29)
- Positronen-Emissions-Tomografie (29)
- Silicium (29)
- Virulenz (29)
- deep learning (29)
- immunotherapy (29)
- survival (29)
- ADHS (28)
- B cells (28)
- Elektrophysiologie (28)
- Exziton (28)
- Fernerkundung (28)
- Fluoreszenzmikroskopie (28)
- Immunsuppression (28)
- Inhibitor (28)
- Malaria (28)
- Maschinelles Lernen (28)
- Microarray (28)
- Polymere (28)
- Proteine (28)
- atherosclerosis (28)
- mouse model (28)
- regulatory T cells (28)
- surgery (28)
- Angiogenese (27)
- DNS-Reparatur (27)
- Epigenetik (27)
- Gehirn (27)
- Mensch (27)
- Parkinson-Krankheit (27)
- Stickstoffmonoxid (27)
- Trypanosoma brucei (27)
- identification (27)
- proliferation (27)
- radiotherapy (27)
- Archäologie (26)
- Bioinformatik (26)
- DNA methylation (26)
- High energy physics (26)
- Human-Animal Studies (26)
- Immunreaktion (26)
- Klimaänderung (26)
- Migration (26)
- Myokardinfarkt (26)
- Raman-Spektroskopie (26)
- Sprachentwicklung (26)
- autophagy (26)
- bone (26)
- dSTORM (26)
- endothelial cells (26)
- learning (26)
- mitochondria (26)
- physics (26)
- positron emission tomography (26)
- stem cells (26)
- virulence (26)
- Cytokine (25)
- DNS-Schädigung (25)
- Environmental Humanities (25)
- Infektion (25)
- Inhibition (25)
- Literary Studies (25)
- MAP-Kinase (25)
- Makrophage (25)
- Mikroskopie (25)
- Parton Distributions (25)
- Polymorphismus (25)
- Prognose (25)
- RNA (25)
- Rezidiv (25)
- Schwertkärpfling (25)
- Verhalten (25)
- blood (25)
- medicine (25)
- microRNA (25)
- regulation (25)
- resistance (25)
- Aminosäuren (24)
- Animal Studies (24)
- Aufsatzsammlung (24)
- BMP (24)
- Bakterien (24)
- Biofilm (24)
- Cultural Animal Studies (24)
- Cultural Studies (24)
- Ecocriticism (24)
- Halbleiter (24)
- Literatur (24)
- Organischer Halbleiter (24)
- Pharmakokinetik (24)
- Tiermodell (24)
- Vaccinia-Virus (24)
- Virtuelle Realität (24)
- chronic kidney disease (24)
- epidemiology (24)
- immunohistochemistry (24)
- mesenchymal stem cells (24)
- miRNS (24)
- migration (24)
- neuroinflammation (24)
- 3D printing (23)
- 3D-Druck (23)
- Atherosklerose (23)
- Autoantikörper (23)
- Cancer (23)
- Fettsucht (23)
- Glioblastom (23)
- Inflammation (23)
- Knochenzement (23)
- Knockout <Molekulargenetik> (23)
- Kognition (23)
- Listeria monocytogenes (23)
- Motoneuron (23)
- Myc (23)
- NMR-Bildgebung (23)
- Parkinson's disease (23)
- Parkinson’s disease (23)
- Zytokine (23)
- activation (23)
- artificial intelligence (23)
- behavior (23)
- colorectal cancer (23)
- cytotoxicity (23)
- development (23)
- disease (23)
- measles virus (23)
- BDNF (22)
- Diagnostik (22)
- Differenzierung (22)
- Expression (22)
- GPCR (22)
- Gedächtnis (22)
- Genanalyse (22)
- P300 (22)
- Pflanzen (22)
- antibodies (22)
- cAMP (22)
- calcium (22)
- classification (22)
- emotion (22)
- extracellular matrix (22)
- memory (22)
- perception (22)
- recurrence (22)
- validation (22)
- Chemotherapie (21)
- Dickdarmkrebs (21)
- Fabry-Krankheit (21)
- Gefühl (21)
- Glaukom (21)
- HPLC (21)
- Hydrogel (21)
- Knochen-Morphogenese-Proteine (21)
- Kollagen (21)
- Optimierung (21)
- Organische Synthese (21)
- Osteoporose (21)
- Screening (21)
- Synapse (21)
- T-Zellen (21)
- TRAIL (21)
- attention (21)
- blood-brain barrier (21)
- chemotherapy (21)
- cytoskeleton (21)
- follow-up (21)
- hippocampus (21)
- human (21)
- neuropathic pain (21)
- osteoporosis (21)
- physical activity (21)
- receptor (21)
- self-assembly (21)
- serotonin (21)
- stress (21)
- toxicity (21)
- transcription (21)
- treatment (21)
- Übergangsmetallkomplexe (21)
- ATLAS detector (20)
- Angststörung (20)
- Aufmerksamkeits-Defizit-Syndrom (20)
- Borylene (20)
- Computersimulation (20)
- Erziehung (20)
- Evaluation (20)
- In vitro (20)
- Insulin (20)
- LHC (20)
- Legionella pneumophila (20)
- Lunge (20)
- Mausmodell (20)
- NMR-Spektroskopie (20)
- Synthese (20)
- adrenocortical carcinoma (20)
- binding (20)
- flow cytometry (20)
- honeybee (20)
- imaging (20)
- metastasis (20)
- mutation (20)
- transcription factors (20)
- transcriptome (20)
- Ameisen (19)
- Antibiotikum (19)
- Apis mellifera (19)
- Cytologie (19)
- Fragebogen (19)
- Genmutation (19)
- HIV-Infektion (19)
- Herzmuskel (19)
- Hippocampus (19)
- Metabolismus (19)
- Palliativmedizin (19)
- Prostatakrebs (19)
- Rezeption (19)
- Sonderpädagogik (19)
- Stoffwechsel (19)
- TNF (19)
- angiogenesis (19)
- biology (19)
- cell death (19)
- echocardiography (19)
- fMRI (19)
- foraging (19)
- immune response (19)
- lymphoma (19)
- management (19)
- mass spectrometry (19)
- miRNA (19)
- p53 (19)
- pregnancy (19)
- sepsis (19)
- Actin (18)
- Autoimmunität (18)
- B-Lymphozyt (18)
- Bildgebendes Verfahren (18)
- Biomechanik (18)
- Boron (18)
- DNS (18)
- EAE (18)
- Europäische Union (18)
- Farbstoff (18)
- G-Protein gekoppelte Rezeptoren (18)
- Herzhypertrophie (18)
- Kaliumkanal (18)
- Krebs (18)
- MRSA (18)
- Neisseria gonorrhoeae (18)
- Netzwerk (18)
- Neurodegeneration (18)
- Niere (18)
- Optische Spektroskopie (18)
- Prävention (18)
- Quecksilbertellurid (18)
- Ultraschall (18)
- Virulenzfaktor (18)
- annual report (18)
- antibiotics (18)
- ants (18)
- autoimmunity (18)
- bacteria (18)
- crystal structure (18)
- deep brain stimulation (18)
- diabetes (18)
- dopamine (18)
- kidney (18)
- land use (18)
- luminescence (18)
- mouse models (18)
- neuroprotection (18)
- outcome (18)
- polymorphism (18)
- risk factors (18)
- spectroscopy (18)
- theranostics (18)
- time series (18)
- topological insulators (18)
- transplantation (18)
- Biodiversität (17)
- Biomaterial (17)
- DFT (17)
- DNA repair (17)
- Fluoreszenz-Resonanz-Energie-Transfer (17)
- Fremdsprachenunterricht (17)
- Helicobacter pylori (17)
- Herzfrequenzvariabilität (17)
- Immunmodulation (17)
- Interaktion (17)
- Julius-Maximilians-Universität Würzburg (17)
- MODIS (17)
- Masern (17)
- Merkel cell carcinoma (17)
- Motivation (17)
- Mutation (17)
- NFATc1 (17)
- NIR-Spektroskopie (17)
- Nachhaltigkeit (17)
- Naphthylisochinolinalkaloide (17)
- Neurogenese (17)
- PET/CT (17)
- Photolumineszenz (17)
- Polyneuropathie (17)
- Pädiatrie (17)
- Resistenz (17)
- Sepsis (17)
- Sol-Gel-Verfahren (17)
- Spinale Muskelatrophie (17)
- Tanzania (17)
- Wirkstoff (17)
- Zellmigration (17)
- Zellskelett (17)
- active zone (17)
- aging (17)
- bees (17)
- blood pressure (17)
- epithelial cells (17)
- gene regulation (17)
- genotoxicity (17)
- immunosuppression (17)
- in vivo (17)
- ischemia (17)
- lung cancer (17)
- nitric oxide (17)
- platelet (17)
- psychology (17)
- tumor (17)
- ARPES (16)
- Arzneimitteldesign (16)
- B-Zell-Lymphom (16)
- Bavaria (16)
- Decay (16)
- Dendritische Zellen (16)
- Digitalisierung (16)
- Embryonalentwicklung (16)
- Emotion (16)
- Endothelzelle (16)
- Festkörperphysik (16)
- Fremdsprachenlernen (16)
- Fuchsbandwurm (16)
- Galliumarsenid (16)
- Heart failure (16)
- Hypertonie (16)
- Konditionierung (16)
- Kongress (16)
- Künstliche Intelligenz (16)
- Magnetresonanztomographie (16)
- Makrophagen (16)
- Methylierung (16)
- Molekulardynamik (16)
- Monte-Carlo-Simulation (16)
- Muscarinrezeptor (16)
- Namibia (16)
- Plattenepithelcarcinom (16)
- RNS (16)
- ROS (16)
- Rheumatoide Arthritis (16)
- Spintronik (16)
- Stammzelltransplantation (16)
- T-cells (16)
- Thrombose (16)
- Ultrakurzzeitspektroskopie (16)
- asthma (16)
- biomarkers (16)
- cells (16)
- diabetes mellitus (16)
- diborenes (16)
- epigenetics (16)
- event-related potentials (16)
- fibrosis (16)
- hemodialysis (16)
- innate immunity (16)
- mRNA (16)
- malaria (16)
- messenger RNA (16)
- metagenomics (16)
- model (16)
- monocytes (16)
- neurodegeneration (16)
- nutrition (16)
- olfaction (16)
- ovarian cancer (16)
- prevalence (16)
- proteins (16)
- simulation (16)
- structure elucidation (16)
- vision (16)
- 1 (15)
- Abscisinsäure (15)
- Allergie (15)
- Bestrahlung (15)
- Colonkrebs (15)
- Cyclo-AMP (15)
- Dichtefunktionalformalismus (15)
- Diffusion (15)
- Drei-Fünf-Halbleiter (15)
- Dünne Schicht (15)
- Echinococcus (15)
- Extension (15)
- Femtosekundenspektroskopie (15)
- Halbleiterlaser (15)
- Implantat (15)
- Kernspintomographie (15)
- Kontrastmittel (15)
- Ligand <Biochemie> (15)
- MYC (15)
- Maligne Hyperthermie (15)
- Massenspektrometrie (15)
- Medicine (15)
- Merocyanine (15)
- Mitochondrium (15)
- Nanostruktur (15)
- Nebenniere (15)
- Onkologie (15)
- Organische Solarzelle (15)
- Phosphorylierung (15)
- Polymerase-Kettenreaktion (15)
- Prostatakarzinom (15)
- Rastertunnelmikroskopie (15)
- Regulatorischer T-Lymphozyt (15)
- Romanistik (15)
- Sentinel-2 (15)
- Supersymmetry (15)
- Transcription (15)
- Transforming Growth Factor beta (15)
- Unterfranken (15)
- Wundheilung (15)
- Xiphophorus (15)
- actin (15)
- association (15)
- bipolar disorder (15)
- conservation (15)
- dendritic cell (15)
- diversity (15)
- ecology (15)
- escherichia coli (15)
- fracture (15)
- glaucoma (15)
- hadron-hadron scattering (15)
- hypertension (15)
- inhibition (15)
- insects (15)
- mental health (15)
- metabolomics (15)
- microscopy (15)
- mushroom body (15)
- neurons (15)
- optogenetics (15)
- pancreatic cancer (15)
- prevention (15)
- proton-proton collision (15)
- rheumatoid arthritis (15)
- supramolecular chemistry (15)
- synthesis (15)
- Ökologie (15)
- Übergangsmetall (15)
- Activation (14)
- Aggregation (14)
- Aldosteron (14)
- Alter Orient (14)
- Alzheimer-Krankheit (14)
- Arzneimittel (14)
- Chemokine (14)
- Chronische Herzinsuffizienz (14)
- Datennetz (14)
- Diabetes (14)
- Einzelmolekülmikroskopie (14)
- Elektroencephalogramm (14)
- Europarecht (14)
- Extrazelluläre Matrix (14)
- Fanconi-Anämie (14)
- Guanylatcyclase (14)
- HNSCC (14)
- Herzchirurgie (14)
- Higgs boson (14)
- Hämodialyse (14)
- Impfung (14)
- Informationsverarbeitung (14)
- Invasion (14)
- Ionenkanal (14)
- Ischämie (14)
- Katalyse (14)
- Kernhülle (14)
- Kolonkarzinom (14)
- Koronare Herzkrankheit (14)
- Lehrerbildung (14)
- Lungenkrebs (14)
- Lymphozyt (14)
- Mammakarzinom (14)
- Meiose (14)
- Mitose (14)
- Monoklonaler Antikörper (14)
- NHC (14)
- NMR (14)
- Natürliche Killerzelle (14)
- Nervenzelle (14)
- Optimale Kontrolle (14)
- PSMA (14)
- Perylenderivate (14)
- Plasmodium falciparum (14)
- Reaktivität (14)
- Real time quantitative PCR (14)
- Rehabilitation (14)
- Remodeling (14)
- Robotik (14)
- SPECT (14)
- Sekundärmetabolit (14)
- Spumaviren (14)
- Strukturaufklärung (14)
- Säugling (14)
- Tansania (14)
- Theoretische Chemie (14)
- Transkription (14)
- Transkription <Genetik> (14)
- Transplantation (14)
- Tumor-Nekrose-Faktor (14)
- Zelle (14)
- Zwei-Sechs-Halbleiter (14)
- additive manufacturing (14)
- borylation (14)
- cardiac hypertrophy (14)
- case report (14)
- chemistry (14)
- circadian clock (14)
- cultural studies (14)
- evaluation (14)
- exercise (14)
- fNIRS (14)
- glioblastoma (14)
- growth (14)
- guidelines (14)
- honey bees (14)
- in-vitro (14)
- in-vivo (14)
- inorganic chemistry (14)
- insulin (14)
- mechanisms (14)
- neutrophils (14)
- performance (14)
- pharmacokinetics (14)
- photoelectron spectroscopy (14)
- prediction (14)
- prefrontal cortex (14)
- quantum dot (14)
- reconstruction (14)
- rehabilitation (14)
- risk (14)
- sphingolipids (14)
- vaccinia virus (14)
- AIDS (13)
- ARDS (13)
- Alter (13)
- Alzheimerkrankheit (13)
- Angiotensin II (13)
- Arbeitsgedächtnis (13)
- Aspergillus (13)
- Asthma (13)
- Aufmerksamkeitsdefizit-Syndrom (13)
- Bibliographie (13)
- Calciumphosphat (13)
- Chlamydia trachomatis (13)
- Computertomographie (13)
- Cytotoxizität (13)
- Elektronischer Transport (13)
- Furcht (13)
- Geographie (13)
- Globalisierung (13)
- Glucocorticosteroide (13)
- Heterocyclische Carbene <-N> (13)
- Heterostruktur (13)
- HgTe (13)
- Hitzeschock-Proteine (13)
- Immunbiologie (13)
- Immunhistochemie (13)
- Insekten (13)
- Interferon (13)
- Komposit (13)
- Konfokale Mikroskopie (13)
- Kulturanthropologie (13)
- Lippen-Kiefer-Gaumenspalte (13)
- Literaturwissenschaft (13)
- MSC (13)
- Microscopy (13)
- Mittelalter (13)
- Morbus Fabry (13)
- NK cells (13)
- Neuronale Plastizität (13)
- Optischer Resonator (13)
- Osteoarthritis (13)
- Parkinson (13)
- Perfusion (13)
- Physics (13)
- Physik (13)
- Quantifizierung (13)
- RNS-Interferenz (13)
- Schwangerschaft (13)
- Sprachwissenschaft (13)
- Stabilität (13)
- Supersymmetrie (13)
- Therapeutisches Drug Monitoring (13)
- Topologie (13)
- Tumorzelle (13)
- VASP (13)
- VEGF (13)
- West Africa (13)
- adolescents (13)
- cGMP (13)
- cardiomyopathy (13)
- cell cycle (13)
- cell staining (13)
- cytokine (13)
- diet (13)
- ecosystem services (13)
- fungi (13)
- gender (13)
- humans (13)
- invasion (13)
- liver (13)
- melt electrowriting (13)
- metaanalysis (13)
- micronuclei (13)
- molecular docking (13)
- mutations (13)
- nanoparticles (13)
- osteoarthritis (13)
- panic disorder (13)
- perylene bisimide (13)
- preterm infants (13)
- reliability (13)
- replication (13)
- symbiosis (13)
- therapeutic drug monitoring (13)
- traumatic brain injury (13)
- working memory (13)
- Überleben (13)
- ALS (12)
- Adenosinrezeptor (12)
- Adhäsion (12)
- Altern (12)
- Aspergillose (12)
- Brain-derived neurotrophic factor (12)
- Comet Assay (12)
- Computer Center University of Wuerzburg (12)
- Dialyse (12)
- Diboren (12)
- Dopamin (12)
- ERP (12)
- FRET (12)
- Fibrose (12)
- Fluorescence (12)
- Gen (12)
- Genotoxizität (12)
- Grundschule (12)
- Hirntumor (12)
- Immunotherapy (12)
- Kinderheilkunde (12)
- Klima (12)
- Klimawandel (12)
- Kohlenstoff-Nanoröhre (12)
- Komplikationen (12)
- Kulturwissenschaften (12)
- Kutikula (12)
- Lymphom (12)
- Magnetische Kernresonanz (12)
- Medienkompetenz (12)
- Metastase (12)
- Modell (12)
- NFAT (12)
- Nanostrukturiertes Material (12)
- Netzhaut (12)
- Nigeria (12)
- Non-Hodgkin-Lymphom (12)
- Onkogen (12)
- PCR (12)
- PRRT (12)
- Pharmakologie (12)
- Pilzkörper (12)
- Polytrauma (12)
- Quality of Experience (12)
- Quantenchemie (12)
- Rekonstruktion (12)
- Religion (12)
- Replikation (12)
- Risikofaktor (12)
- Rotatorenmanschette (12)
- Ruthenium (12)
- SMN (12)
- SNP (12)
- Siliciumorganische Verbindungen (12)
- Spracherwerb (12)
- Toll-like-Rezeptoren (12)
- Ultrakurzer Lichtimpuls (12)
- Validierung (12)
- Zelladhäsion (12)
- age (12)
- animal model (12)
- antibody (12)
- autoantibodies (12)
- biofabrication (12)
- blood–brain barrier (12)
- carbenes (12)
- cartilage (12)
- catalysis (12)
- colorectal carcinoma (12)
- complications (12)
- database (12)
- dementia (12)
- drug delivery (12)
- dynamics (12)
- emotions (12)
- endothelium (12)
- enzyme replacement therapy (12)
- fear conditioning (12)
- genome (12)
- head and neck cancer (12)
- interaction (12)
- lymphocytes (12)
- malignant hyperthermia (12)
- measles (12)
- microarray (12)
- molecular beam epitaxy (12)
- monoclonal antibodies (12)
- neurology (12)
- neuropathy (12)
- optimization (12)
- pollen (12)
- polymers (12)
- proteomics (12)
- rats (12)
- recombination (12)
- screening (12)
- super-resolution microscopy (12)
- synaptic plasticity (12)
- systematic review (12)
- tinnitus (12)
- total knee arthroplasty (12)
- trabeculectomy (12)
- translation (12)
- ubiquitin (12)
- ultrasound (12)
- vitamin D (12)
- vorsprachliche Entwicklung (12)
- zebrafish (12)
- ++ (11)
- 3D (11)
- Alzheimer’s disease (11)
- Anorexia nervosa (11)
- Antigen CD8 (11)
- Arabidopsis (11)
- B-Zelle (11)
- Bioisosterie (11)
- Biosynthese (11)
- Bioverfügbarkeit (11)
- Bruchpilot (11)
- Candida (11)
- Chromatin (11)
- Click-Chemie (11)
- Computertomografie (11)
- Durchflusscytometrie (11)
- Dynamik (11)
- EGFR (11)
- Elektronentransfer (11)
- Enzym (11)
- Epidemiologie (11)
- Epidermaler Wachstumsfaktor-Rezeptor (11)
- Flavonoide (11)
- Fließverhalten (11)
- Fotovoltaik (11)
- Genom (11)
- Geschlecht (11)
- Hypoxie (11)
- Immuncytochemie (11)
- Japankärpfling (11)
- Knochen (11)
- Knochenersatz (11)
- Kolorektales Karzinom (11)
- LPS (11)
- Laser (11)
- Längsschnittuntersuchung (11)
- MS (11)
- Mais (11)
- Mathematik (11)
- Megakaryozyt (11)
- Mensch-Maschine-Kommunikation (11)
- Mesenchymale Stammzellen (11)
- Mesenchymzelle (11)
- Model (11)
- Monitoring (11)
- NIRS (11)
- Nanodiamant (11)
- Neuropathie (11)
- Niereninsuffizienz (11)
- Operation (11)
- Osteoinduktion (11)
- Parathormon (11)
- Perylenbisimid (11)
- Phylogenie (11)
- Proteaseinhibitor (11)
- Proteasen (11)
- Psychiatrie (11)
- Pulmonale Hypertonie (11)
- Quality of life (11)
- Quanten-Hall-Effekt (11)
- Reperfusion (11)
- Risikofaktoren (11)
- Salmonella (11)
- Schizophrenia (11)
- Schlafapnoe (11)
- Schließzelle (11)
- Schule (11)
- Schultergelenk (11)
- Schädel-Hirn-Trauma (11)
- Silicate (11)
- Skala (11)
- Small RNA (11)
- Sprache (11)
- Squark (11)
- Stammzellen (11)
- Sterblichkeit (11)
- Supraleitung (11)
- Symbiose (11)
- T cell (11)
- TWEAK (11)
- Training (11)
- Tuberkelbakterium (11)
- Tumor-Nekrose-Faktor <alpha> (11)
- USA (11)
- Ubiquitin (11)
- Vasodilatator-stimuliertes Phosphoprotein (11)
- Wahrnehmung (11)
- Westafrika (11)
- Zelltod (11)
- adhesion (11)
- allergy (11)
- amygdala (11)
- atrial fibrillation (11)
- biocompatibility (11)
- biofilm (11)
- cancer treatment (11)
- cell adhesion (11)
- cochlear implant (11)
- communication (11)
- coping (11)
- dosimetry (11)
- fluorescence microscopy (11)
- genomics (11)
- glioblastoma multiforme (11)
- heart rate (11)
- hypoxia (11)
- immunology (11)
- kinetics (11)
- lung (11)
- mechanism (11)
- meiosis (11)
- membrane proteins (11)
- microbiome (11)
- microglia (11)
- molecular dynamics (11)
- molecular imaging (11)
- nervous system (11)
- neural networks (11)
- neuroendocrine tumor (11)
- next generation sequencing (11)
- nuclear envelope (11)
- oncolytic virus (11)
- periodontitis (11)
- plasticity (11)
- pollination (11)
- randomized controlled trial (11)
- reactive oxygen species (11)
- relapse (11)
- review (11)
- safety (11)
- signaling (11)
- thrombosis (11)
- topological insulator (11)
- transport (11)
- tumor microenvironment (11)
- university (11)
- Alkohol (10)
- Alzheimer's disease (10)
- Antigen CD28 (10)
- Arzneimittelüberwachung (10)
- Atherosclerosis (10)
- BERA (10)
- BMP-2 (10)
- Bacteria (10)
- Bakterielle Infektion (10)
- Beschichtung (10)
- Bildverarbeitung (10)
- Bioinformatics (10)
- Biokompatibilität (10)
- Blazar (10)
- Borole (10)
- CRISPR/Cas-Methode (10)
- CRISPR/Cas9 (10)
- Cadherine (10)
- Calciumphosphate (10)
- Carbene (10)
- Children (10)
- Chronische Niereninsuffizienz (10)
- Churritisch (10)
- Cochlear-Implantat (10)
- Coronaviren (10)
- Covid-19 (10)
- Cyclo-GMP (10)
- Depressivität (10)
- Diamant (10)
- Digital Humanities (10)
- Dimerisierung (10)
- Dotierung (10)
- Echokardiographie (10)
- Eierstockkrebs (10)
- Elektrochemie (10)
- Elektronenkorrelation (10)
- Englisch (10)
- Enzyminhibitor (10)
- Erbkrankheit (10)
- Ereigniskorreliertes Potenzial (10)
- Erwachsener (10)
- Franken (10)
- Frau (10)
- Funktionalisierung <Chemie> (10)
- Funktionelle Kernspintomografie (10)
- Förderung (10)
- Geldpolitik (10)
- Glatter Krallenfrosch (10)
- Grenzfläche (10)
- HSM-Satztest (10)
- Herzmuskelzelle (10)
- Honigbiene (10)
- Hypophosphatasie (10)
- Immunology (10)
- Impfstoff (10)
- Induzierte pluripotente Stammzelle (10)
- Interleukin 4 (10)
- JNK (10)
- Klassifikation (10)
- Kniegelenk (10)
- Kohlenstoff (10)
- Komplikation (10)
- Kooperation (10)
- Kultur (10)
- LASP1 (10)
- LC-MS (10)
- Ladungstransfer (10)
- Ligand (10)
- Lokalisation (10)
- Magnesiumphosphate (10)
- Mathematikunterricht (10)
- Mathematisches Modell (10)
- Medulloblastom (10)
- Metakognition (10)
- Metallocene (10)
- Methylphenidat (10)
- Mikrokerne (10)
- Multiple Myeloma (10)
- Musik (10)
- Mutagenität (10)
- Nahrungserwerb (10)
- Nebennierenrindenkarzinom (10)
- Neolithikum (10)
- Neuropathischer Schmerz (10)
- Niger (10)
- Osteosynthese (10)
- Pain (10)
- Panikstörung (10)
- Parasit (10)
- Parodontitis (10)
- Pathogenität (10)
- Platelets (10)
- Plattenepithelkarzinom (10)
- Prevalence (10)
- Prostaglandine (10)
- Präfrontaler Cortex (10)
- Psychotherapie (10)
- Pädagogik (10)
- Qualitätskontrolle (10)
- RNA interference (10)
- RNA-seq (10)
- RNS-Spleißen (10)
- Radiotherapy (10)
- Remote Sensing (10)
- Rhodium (10)
- Rituximab (10)
- SAR (10)
- Schilddrüse (10)
- Silaanaloga (10)
- Silber (10)
- Silicon (10)
- South Africa (10)
- Sphingolipide (10)
- Sprachverstehen (10)
- Starke Kopplung (10)
- Stickstoffmonoxid-Synthase (10)
- Stressreaktion (10)
- Stroke (10)
- Struktur (10)
- T-Lymphozyten (10)
- T-Lymphozyten-Rezeptor (10)
- Tagesrhythmus (10)
- Totalsynthese (10)
- Toxizität (10)
- Transplantat-Wirt-Reaktion (10)
- Transthorakale Echokardiographie (10)
- Treg (10)
- Trypanosomen (10)
- Verwaltungsrecht (10)
- Vitamin D (10)
- Vor- und Frühgeschichte (10)
- Vorschulkind (10)
- Wachstum (10)
- Zebrabärbling (10)
- amino acids (10)
- antimicrobial resistance (10)
- bariatric surgery (10)
- biosynthesis (10)
- boranes (10)
- chemokines (10)
- chronic heart failure (10)
- circadian rhythms (10)
- clinical trial (10)
- comparison (10)
- complex (10)
- coronary artery disease (10)
- decision-making (10)
- density functional calculations (10)
- eNOS (10)
- education (10)
- emotion regulation (10)
- fatigue (10)
- fear (10)
- genome-wide association (10)
- global change (10)
- hydrogels (10)
- immunomodulation (10)
- induced pluripotent stem cells (10)
- injury (10)
- insect (10)
- knockout (10)
- leaf-cutting ants (10)
- leukemia (10)
- lymph nodes (10)
- mapping (10)
- membrane potential (10)
- motivation (10)
- oncology (10)
- oncolytic virotherapy (10)
- oxidativer Stress (10)
- phenotype (10)
- quality assurance (10)
- regulatorische T-Zellen (10)
- remodeling (10)
- senescence (10)
- silicon (10)
- social interaction (10)
- stem cell transplantation (10)
- tDCS (10)
- tight junctions (10)
- tumors (10)
- vaccination (10)
- vertigo (10)
- water oxidation (10)
- Östrogene (10)
- 3 (9)
- Adenosin (9)
- Adenosine receptors (9)
- Affekt (9)
- Afrika (9)
- Alps (9)
- Analyse (9)
- Angeregter Zustand (9)
- Anxiety (9)
- Aorta (9)
- Aortenstenose (9)
- Bauchspeicheldrüsenkrebs (9)
- Beyond Standard Model (9)
- Biotransformation (9)
- Bordetella pertussis (9)
- Borylierung (9)
- Boğazkale (9)
- Butyrat (9)
- Carcinogenese (9)
- Catalysis (9)
- Chiralität <Chemie> (9)
- Cloud Computing (9)
- Computational chemistry (9)
- Deep learning (9)
- Dendritic cells (9)
- Diagnose (9)
- Diborane (9)
- Diskursanalyse (9)
- Dünndarm (9)
- Einzelphotonenemission (9)
- Elektroencephalographie (9)
- Elektronenmikroskopie (9)
- Elektronenstruktur (9)
- Elementarteilchenphysik (9)
- Epithel (9)
- Ernährung (9)
- Experimentelle Psychologie (9)
- Extremwertstatistik (9)
- Familie (9)
- Fanconi Anämie (9)
- Fettgewebe (9)
- Fibroblastenwachstumsfaktor (9)
- Fibromyalgie (9)
- Frühgeborene (9)
- GIS (9)
- Geistigbehindertenpädagogik (9)
- Gentherapie (9)
- Geoinformationssystem (9)
- Geruchswahrnehmung (9)
- Glioblastoma (9)
- Google Earth Engine (9)
- Grammatik (9)
- Handlungsorientierung (9)
- Haut (9)
- Herzmuskelkrankheit (9)
- Hethiter (9)
- Hyaluronsäure (9)
- IL-4 (9)
- Immunfluoreszenz (9)
- Immunisierung (9)
- Innovation (9)
- Instrumentelle Analytik (9)
- Integrine (9)
- Interview (9)
- Iran (9)
- Isolierung <Chemie> (9)
- Jugendliche (9)
- Kapillarelektrophorese (9)
- Knorpel (9)
- Kommunikation (9)
- Konflikt (9)
- Koordinationslehre (9)
- Korpus <Linguistik> (9)
- Landsat (9)
- Leber (9)
- Linguistik (9)
- Löslichkeit (9)
- MAPK (9)
- Macrophage (9)
- Magnetische Resonanz (9)
- Magnetismus (9)
- Mehrfachbindung (9)
- Mehrsprachigkeit (9)
- Messenger-RNS (9)
- Mice (9)
- Molekulare Erkennung (9)
- Monozyt (9)
- Morphologie (9)
- Mukoviszidose (9)
- Myokardprotektion (9)
- NAFLD (9)
- NO (9)
- Nebennierenrindenkrebs (9)
- Neuroinflammation (9)
- Nierentransplantation (9)
- Oberfläche (9)
- Oberflächenphysik (9)
- Optoelektronik (9)
- PD-1 (9)
- PD-L1 (9)
- Pathogenese (9)
- Persönlichkeit (9)
- Pharmakotherapie (9)
- Photolumineszenzspektroskopie (9)
- Physiologie (9)
- Plasmamembran (9)
- Protein (9)
- Pseudomonas syringae (9)
- Psychoonkologie (9)
- Quantenmechanik (9)
- Rechenzentrum (9)
- Rechtsvergleich (9)
- Regeneration (9)
- Regionalentwicklung (9)
- Revision (9)
- Sarkoidose (9)
- Satellit (9)
- Schmalwand <Arabidopsis> (9)
- Schwindel (9)
- Schüttgut (9)
- Sentinel-1 (9)
- Spin-Bahn-Wechselwirkung (9)
- Squaraine (9)
- Staphylococcus (9)
- Stathmin (9)
- Stereoselektive Synthese (9)
- Supply Chain Management (9)
- Syntax (9)
- Systembiologie (9)
- Südafrika (9)
- Textverstehen (9)
- Theologie (9)
- Therapy (9)
- Tourismus (9)
- Trabekulektomie (9)
- Transplantat (9)
- Transport (9)
- Trypanosoma (9)
- Tumorantigen (9)
- Vakuole (9)
- Vergleich (9)
- Visuelle Aufmerksamkeit (9)
- Wurzel (9)
- X-ray crystallography (9)
- Zellkern (9)
- Zentralnervensystem (9)
- Zinkselenid (9)
- aggregation (9)
- agriculture (9)
- aldosterone (9)
- antennal lobe (9)
- anxiety disorders (9)
- aromaticity (9)
- bioinformatics (9)
- biomechanics (9)
- blood brain barrier (9)
- body size (9)
- bone cement (9)
- bone marrow (9)
- cancer therapy (9)
- cardiac surgery (9)
- cell culture (9)
- cell migration (9)
- cell wall (9)
- central nervous system (9)
- cerebrospinal fluid (9)
- chromatin (9)
- cognitive impairment (9)
- collagen (9)
- coronary heart disease (9)
- cuticular hydrocarbons (9)
- cystic fibrosis (9)
- decision making (9)
- dendritische Zellen (9)
- dialysis (9)
- dispersal (9)
- earth observation (9)
- electron microscopy (9)
- electronic properties and materials (9)
- electrophysiology (9)
- energy (9)
- experimental autoimmune encephalomyelitis (9)
- family (9)
- forest (9)
- gene therapy (9)
- glioma (9)
- glucose (9)
- high energy physics (9)
- hip (9)
- hyaluronic acid (9)
- hydrogel (9)
- impact (9)
- incidence (9)
- inhibitor (9)
- interferon (9)
- mechanotransduction (9)
- mesenchymale Stammzellen (9)
- metapopulation (9)
- methylation (9)
- mitosis (9)
- molecular biology (9)
- monitoring (9)
- monoklonale Antikörper (9)
- myocardium (9)
- navigation (9)
- near-infrared spectroscopy (9)
- neuroscience (9)
- organic chemistry (9)
- organic semiconductors (9)
- pathway (9)
- perfusion (9)
- peripheral nervous system (9)
- permeability (9)
- personality (9)
- platelet activation (9)
- platelet aggregation (9)
- prognostic factors (9)
- quantification (9)
- rectal cancer (9)
- reveals (9)
- serum (9)
- spinal muscular atrophy (9)
- synapse (9)
- systematic uncertainty (9)
- temperature (9)
- tolerance (9)
- transcription factor (9)
- transient absorption (9)
- transmission (9)
- type 2 diabetes (9)
- vaccine (9)
- walking (9)
- water (9)
- wound healing (9)
- Übersetzung (9)
- ATLAS (8)
- Adhärenz (8)
- Aggregat <Chemie> (8)
- Akt (8)
- Aktiver galaktischer Kern (8)
- Algorithmus (8)
- Alltagskultur (8)
- Ancistrocladaceae (8)
- Anthocyane (8)
- Antibiotika (8)
- Antigen (8)
- Antigen CD40 (8)
- Aortenklappenersatz (8)
- Arthrose (8)
- Arthroskopie (8)
- Arzneimittelforschung (8)
- Asymmetrie (8)
- Asymmetrische Synthese (8)
- Auge (8)
- Autoaggressionskrankheit (8)
- Autonomer Roboter (8)
- Autophagie (8)
- Bauchspeicheldrüse (8)
- Biradikal (8)
- Blimp-1 (8)
- Blutdruck (8)
- Blutstammzelle (8)
- Botanik (8)
- Brain (8)
- Burkina Faso (8)
- CD28 (8)
- CD40 (8)
- CD95 (8)
- COMT (8)
- CT (8)
- Caenorhabditis elegans (8)
- Camponotus floridanus (8)
- Chlamydia (8)
- Compressed Sensing (8)
- Cross-Section (8)
- Cysteinproteasen (8)
- Cytomegalie-Virus (8)
- DLBCL (8)
- Darm (8)
- Data Mining (8)
- Datenbank (8)
- Degradation (8)
- Demenz (8)
- Deutschunterricht (8)
- Diborene (8)
- ERK (8)
- Elektronenspin (8)
- Elektronenspinresonanz (8)
- Emotionsregulation (8)
- Endothelzellen (8)
- Engagement (8)
- Erbrechen (8)
- Europa (8)
- Europe (8)
- Fachdidaktik (8)
- Femtosekundenbereich (8)
- Fibroblasten (8)
- Finite-Elemente-Methode (8)
- Fitness (8)
- Fluoreszenzspektroskopie (8)
- Forschung (8)
- Fußball (8)
- GABA (8)
- Gammastrahlung (8)
- Gedächtnisleistung (8)
- Geschlechtsunterschied (8)
- Gewebe (8)
- Gliom (8)
- Graphen (8)
- HPLC-MS (8)
- Habichtskraut (8)
- Haemophilus influenzae (8)
- Harnwegsinfektion (8)
- Hernie (8)
- Hochbegabung (8)
- Hubbard-Modell (8)
- Humangenetik (8)
- Hymenoptera (8)
- Hypertrophie (8)
- Hüftgelenk (8)
- IL-10 (8)
- Immunantwort (8)
- Impulsivität (8)
- In vivo (8)
- India (8)
- Indien (8)
- Inklusion (8)
- Juvenile chronische Arthritis (8)
- Keilschrifttext (8)
- Kephalometrie (8)
- Kieferorthopädie (8)
- Kinetik (8)
- Kleinsatellit (8)
- Knockout (8)
- Komposit <Zahnmedizin> (8)
- Kondo-Effekt (8)
- Korrelation (8)
- Kreuzband (8)
- Kristallstruktur (8)
- LC-MS/MS (8)
- Landwirtschaft (8)
- Langerhans-Inseln (8)
- Lanthanoide (8)
- Lehre (8)
- Leishmania (8)
- Lernautonomie (8)
- Lower Franconia (8)
- Lumineszenz (8)
- Lungenfibrose (8)
- Machine Learning (8)
- Magenbypass (8)
- Makuladegeneration (8)
- Mass (8)
- Meeresschwämme (8)
- Meiosis (8)
- Meningitis (8)
- Meningokokken (8)
- Metaanalyse (8)
- Methode (8)
- Mikroglia (8)
- Mikrokerntest (8)
- Mikrostruktur (8)
- Mitochondrien (8)
- Mobiler Roboter (8)
- Molekül (8)
- Monozyten (8)
- Multiple myeloma (8)
- N-heterocyclic carbenes (8)
- NSCLC (8)
- Nachsorge (8)
- Naturstoff (8)
- Neugeborenes (8)
- Neutrino (8)
- Obesity (8)
- Onkolyse (8)
- Optogenetik (8)
- Organisches Molekül (8)
- Oxylipine (8)
- PONV (8)
- Pankreaskarzinom (8)
- Parton distributions (8)
- Pemphigus (8)
- Peptide (8)
- Periphere arterielle Verschlusskrankheit (8)
- Permeabilität (8)
- Pharmakodynamik (8)
- Photodissoziation (8)
- Photovoltaik (8)
- Platin (8)
- Pollen (8)
- Polycyclische Aromaten (8)
- Protein p53 (8)
- Protein-Tyrosin-Kinasen (8)
- Proteinbindung (8)
- Protonen-NMR-Spektroskopie (8)
- Präkonditionierung (8)
- Psychische Störung (8)
- Pump-Probe-Technik (8)
- Quantendynamik (8)
- Quelle (8)
- Quran (8)
- Radikal <Chemie> (8)
- Raf <Biochemie> (8)
- Raf-Kinasen (8)
- Raman spectroscopy (8)
- Rastertunnelmikroskop (8)
- Rechenzentrum Universität Würzburg (8)
- Regenerative Medizin (8)
- Rekombination (8)
- Retroviren (8)
- Ringöffnungspolymerisation (8)
- Roman (8)
- Röntgen-Photoelektronenspektroskopie (8)
- Salmonella typhimurium (8)
- Schmerzforschung (8)
- Schwämme (8)
- Semimagnetischer Halbleiter (8)
- Siliciumcarbid (8)
- Sozialpsychologie (8)
- Sprachaudiometrie (8)
- Statistik (8)
- Stent (8)
- Stofftransport <Biologie> (8)
- Survival (8)
- Synthesis (8)
- T cell activation (8)
- T lymphocytes (8)
- T-Zelle (8)
- TDM (8)
- Tabak (8)
- Tagung (8)
- Text Mining (8)
- Textanalyse (8)
- Thrombosis (8)
- Thrombozyten (8)
- Thymus (8)
- Tight junction (8)
- Titan (8)
- Transkriptomanalyse (8)
- Trauma (8)
- Trypanosomiase (8)
- Tumorimmunologie (8)
- UAV (8)
- Ultraschalldiagnostik (8)
- Virusinfektion (8)
- Visualisierung (8)
- Vulnerabilität (8)
- Wirkstofffreisetzung (8)
- Zahnmedizin (8)
- Zeitreihenanalyse (8)
- actin cytoskeleton (8)
- acute kidney injury (8)
- adherence (8)
- adolescence (8)
- allogeneic stem cell transplantation (8)
- amyotrophic lateral sclerosis (8)
- analysis of variance (8)
- animal models (8)
- antigen (8)
- astrocytes (8)
- bladder cancer (8)
- body mass index (8)
- borylene (8)
- calcium phosphate (8)
- cardiovascular disease (8)
- cell biology (8)
- central complex (8)
- ceramide (8)
- charge transfer (8)
- chronic pain (8)
- classical conditioning (8)
- cleft lip and palate (8)
- coagulation (8)
- coherence (8)
- computed tomography (8)
- copper (8)
- cortisol (8)
- crystallization (8)
- cytotoxic T cells (8)
- decay (8)
- distribution (8)
- division of labor (8)
- domain (8)
- dystonia (8)
- electroencephalography (8)
- electronic structure (8)
- embodiment (8)
- endocytosis (8)
- extinction (8)
- flavonoids (8)
- foamy virus (8)
- forest management (8)
- gephyrin (8)
- glycine receptor (8)
- health-related quality of life (8)
- hearing (8)
- histology (8)
- immune evasion (8)
- implant (8)
- in vivo imaging (8)
- integrins (8)
- iron (8)
- jet energy scale (8)
- juvenile idiopathic arthritis (8)
- kinematic alignment (8)
- knee (8)
- latency (8)
- learning and memory (8)
- mHealth (8)
- macrophage (8)
- major depression (8)
- meta-analysis (8)
- methylphenidate (8)
- microenvironment (8)
- microstructure (8)
- monocyte (8)
- mutualism (8)
- neurogenesis (8)
- optical spectroscopy (8)
- optimal control (8)
- organic solar cells (8)
- organoids (8)
- pancreas (8)
- pathogens (8)
- pediatrics (8)
- permafrost (8)
- pharmacology (8)
- photocatalysis (8)
- phylogeny (8)
- polycyclic aromatic hydrocarbons (8)
- preconditioning (8)
- presence (8)
- primary care (8)
- progression (8)
- protease (8)
- pulmonary hypertension (8)
- quantum dots (8)
- questionnaire (8)
- radiation (8)
- radicals (8)
- radioligand therapy (8)
- receptors (8)
- scaffold (8)
- secondary structure (8)
- secretion (8)
- selection (8)
- semiconductor (8)
- shoulder (8)
- sleep (8)
- smoking (8)
- social insects (8)
- sodium (8)
- species richness (8)
- spintronics (8)
- staphylococcus aureus (8)
- structure (8)
- subthalamic nucleus (8)
- susceptibility (8)
- targeted therapy (8)
- technology (8)
- thymus (8)
- tool (8)
- transcriptomics (8)
- 3D tissue model (7)
- 53BP1 (7)
- Adsorption (7)
- Adulte Stammzelle (7)
- Africa (7)
- Aktin (7)
- Aktivierung (7)
- Aktivierung <Physiologie> (7)
- Akute myeloische Leukämie (7)
- Akutes Nierenversagen (7)
- Alzheimer disease (7)
- Anpassung (7)
- Antagonist (7)
- Anämie (7)
- Astrophysik (7)
- Audiologie (7)
- Audiometrie (7)
- Ausbreitung (7)
- Autoimmunity (7)
- B-Zellen (7)
- Behandlung (7)
- Behinderung (7)
- Bindungsaktivierung (7)
- Biographie (7)
- Blattschneiderameisen (7)
- Blut (7)
- Blutgerinnung (7)
- Bordetella (7)
- Borylenkomplexe (7)
- CMV (7)
- CNS (7)
- Calciumkanal (7)
- Catecholmethyltransferase <Catechol-0-Methyltransferase> (7)
- Charakterisierung (7)
- Charcot-Marie-Tooth (7)
- Chronobiologie (7)
- Chrysomelidae (7)
- Cisplatin (7)
- Coronavirus (7)
- Cytoskeleton (7)
- DHEA (7)
- DNS-Doppelstrangbruch (7)
- Deutsch als Fremdsprache (7)
- Didaktik (7)
- Differentielle Genexpression (7)
- Dopamine (7)
- Durchblutung (7)
- Durchflusszytometrie (7)
- Dysgnathie (7)
- E-Learning (7)
- ELISA (7)
- ELISPOT (7)
- EMG (7)
- ERK1/2 (7)
- ERN (7)
- Einwandige Kohlenstoff-Nanoröhre (7)
- Eisen (7)
- Elektrokardiogramm (7)
- Embryo (7)
- Endoprothetik (7)
- Ethik (7)
- Exziton-Polariton (7)
- FISH (7)
- Fahrsimulator (7)
- Festkörperoberfläche (7)
- Fibroblast (7)
- Fluoreszenz-in-situ-Hybridisierung (7)
- Flüssigkristall (7)
- Fortpflanzung (7)
- Fraktur (7)
- Freundschaft (7)
- Gallium (7)
- Gehirn-Computer-Schnittstelle (7)
- Geistige Behinderung (7)
- Gelenkknorpel (7)
- Genetics (7)
- Genotoxicity (7)
- Geochemie (7)
- Geologie (7)
- Geomorphologie (7)
- Geriatrie (7)
- Germanium (7)
- Geruch (7)
- Geruchssinn (7)
- Geschlechterforschung (7)
- Gesellschaftsrecht (7)
- Gewalt (7)
- Graft-versus-host-disease (7)
- Guillain-Barré-Syndrom (7)
- HIV-1 (7)
- HUVEC (7)
- Heart (7)
- Herzfrequenz (7)
- Hfq (7)
- Histologie (7)
- Hyaliner Knorpel (7)
- Hypervalentes Molekül (7)
- Hämostase (7)
- Immunglobuline (7)
- Innenstadt (7)
- Integrin (7)
- Interleukin 6 (7)
- Internet (7)
- Jasmonate (7)
- KHK (7)
- Kandidatengen (7)
- Kardiologie (7)
- Kardiomyopathie (7)
- Keramik (7)
- Keratinozyten (7)
- Kindheit (7)
- Kniegelenkprothese (7)
- Knieprothese (7)
- Knochenersatzmaterial (7)
- Knochenregeneration (7)
- Kohlenwasserstoffe (7)
- Komplement <Immunologie> (7)
- Komplexe (7)
- Koordinationspolymere (7)
- Koran (7)
- Kutikularwachs (7)
- LEED (7)
- Landnutzung (7)
- Langzeitergebnisse (7)
- Learning autonomy (7)
- Leishmaniose (7)
- Lernerautonomie (7)
- Lithium-Ionen-Akkumulator (7)
- Lungenfunktion (7)
- MBE (7)
- MYCN (7)
- Macht (7)
- Mangan (7)
- Manganarsenide (7)
- Mehragentensystem (7)
- Membranproteine (7)
- Metapopulation (7)
- Mimik (7)
- Molekularbewegung (7)
- Monte Carlo (7)
- Monte-Carlo (7)
- Mortalität (7)
- Motilität (7)
- Motorisches Lernen (7)
- Mundschleimhaut (7)
- Museum (7)
- Myokarditis (7)
- N-Myc (7)
- NDVI (7)
- Nanodraht (7)
- Nash-Gleichgewicht (7)
- Naturstoffe (7)
- Neolithic (7)
- Nervendegeneration (7)
- Neuralgie (7)
- Neuroblastom (7)
- Neuroethologie (7)
- Neurootologie (7)
- Newton-Verfahren (7)
- Nierenfunktion (7)
- Nierenversagen (7)
- Nierenzellkarzinom (7)
- Notfallmedizin (7)
- Nuklearmedizin (7)
- Ontogenie (7)
- Operations Management (7)
- Organisation (7)
- Outcome (7)
- Oxidation (7)
- Paniksyndrom (7)
- Performance Evaluation (7)
- Phagozytose (7)
- Pheromon (7)
- Photochemie (7)
- Photoionisation (7)
- Plasma (7)
- Promotor (7)
- Propofol (7)
- Proteinkinase C (7)
- Proteomanalyse (7)
- Pulsformung (7)
- Qualität (7)
- Qualitätssicherung (7)
- Quantenwell (7)
- REMPI (7)
- Raman (7)
- Ranvier-Schnürring (7)
- Rat (7)
- Rechnungslegung (7)
- Rechtschreibung (7)
- Regulierung (7)
- Röntgenspektroskopie (7)
- SARS (7)
- SERS (7)
- SGLT1 (7)
- SMA (7)
- STAT3 (7)
- Saccharomyces cerevisiae (7)
- Sandwich-Verbindungen (7)
- Schilddrüsenkrebs (7)
- Schistosomiasis (7)
- Schmerztherapie (7)
- Schulleistung (7)
- Schulter (7)
- Siliciumdioxid (7)
- Soziale Insekten (7)
- Spanisch (7)
- Spin (7)
- Spintronics (7)
- Spiroergometrie (7)
- Stadtplanung (7)
- Steuerrecht (7)
- Strategisches Management (7)
- Struvit (7)
- Studie (7)
- Störlärm (7)
- Subarachnoidalblutung (7)
- Synchrotronstrahlung (7)
- Systematik (7)
- Säugetiere (7)
- T cell receptor (7)
- TRAF2 (7)
- Tissue engineering (7)
- Toxoplasma gondii (7)
- Transcriptome (7)
- Transfektion (7)
- TrkB (7)
- Ubiquitinierung (7)
- United States (7)
- Unternehmen (7)
- Unternehmensbewertung (7)
- Unterricht (7)
- Vagus (7)
- Vascular endothelial Growth Factor (7)
- Vaskularisation (7)
- Vegetation (7)
- Verbraucherverhalten (7)
- Verkehrspsychologie (7)
- Verunreinigung (7)
- Vestibularisschwannom (7)
- Wilms tumor (7)
- Wolfram (7)
- Wundinfektion (7)
- X-ray (7)
- Zellwand (7)
- Zoologie (7)
- Zytoskelett (7)
- Zytotoxizität (7)
- absorption (7)
- acute ischemic stroke (7)
- acute myeloid leukemia (7)
- adaptation (7)
- adipose tissue (7)
- adolescent (7)
- adult neurogenesis (7)
- adults (7)
- ageing (7)
- aggression (7)
- algorithm (7)
- altitudinal gradient (7)
- anemia (7)
- animal behavior (7)
- antibacterial activity (7)
- antibiotic resistance (7)
- antidepressant (7)
- arabidopsis thaliana (7)
- automation (7)
- behaviour (7)
- bioprinting (7)
- blood flow (7)
- bone mineral density (7)
- brain development (7)
- brain-computer interface (7)
- butyrate (7)
- caffeine (7)
- capillary electrophoresis (7)
- carbon dioxide (7)
- carcinoma (7)
- cell membranes (7)
- change detection (7)
- chemokine receptor (7)
- click chemistry (7)
- cognition (7)
- cognitive control (7)
- cognitive decline (7)
- comparative genomics (7)
- complexes (7)
- complexity (7)
- cytokinesis (7)
- degeneration (7)
- degradation (7)
- design (7)
- developmental biology (7)
- diagnostics (7)
- diborynes (7)
- diffusion (7)
- drought (7)
- drug (7)
- drug design (7)
- dyes (7)
- efficacy (7)
- exciton (7)
- extracellular vesicles (7)
- facial expression (7)
- facial expressions (7)
- feedback (7)
- femtosecond spectroscopy (7)
- fibromyalgia syndrome (7)
- fluorescent probes (7)
- fungal infection (7)
- gastric cancer (7)
- gastrointestinal tract (7)
- genes (7)
- genomic damage (7)
- glucocorticoid receptor (7)
- guard cell (7)
- heterocycles (7)
- honey bee (7)
- human behaviour (7)
- hymenoptera (7)
- hypophosphatasia (7)
- immersion (7)
- immunofluorescence (7)
- immunoprecipitation (7)
- inflammatory bowel disease (7)
- kinase (7)
- knockout mice (7)
- kolorektales Karzinom (7)
- lithium (7)
- localization (7)
- locomotion (7)
- luciferase (7)
- megakaryocytes (7)
- melt electrospinning writing (7)
- membrane (7)
- meningitis (7)
- methionine (7)
- microbiology (7)
- minimally invasive (7)
- modeling (7)
- monoclonal antibody (7)
- morphology (7)
- motility (7)
- motoneuron (7)
- motor learning (7)
- mri (7)
- multicenter (7)
- myelin (7)
- nanodiamond (7)
- neuroblastoma (7)
- neuromuscular junction (7)
- neurotrophins (7)
- noise (7)
- nucleus (7)
- oxidation (7)
- pH (7)
- pediatric (7)
- pemphigus (7)
- photoinduced electron transfer (7)
- plasmodium falciparum (7)
- population (7)
- potassium (7)
- pre-speech development (7)
- precision medicine (7)
- prospective (7)
- psoriasis (7)
- public health (7)
- pulse shaping (7)
- quantum dynamics (7)
- radioiodine therapy (7)
- random forest (7)
- recognition (7)
- recovery (7)
- recruitment (7)
- reperfusion (7)
- resilience (7)
- responses (7)
- retina (7)
- risk factor (7)
- rotator cuff (7)
- sRNA (7)
- salt stress (7)
- secondary prevention (7)
- segmentation (7)
- semiconductors (7)
- serotonin transporter (7)
- sex chromosomes (7)
- sex differences (7)
- shear stress (7)
- signaltransduction (7)
- small RNA (7)
- small fiber neuropathy (7)
- social anxiety (7)
- social cognition (7)
- software (7)
- speech audiometry (7)
- superconductivity (7)
- survey (7)
- target (7)
- taxonomy (7)
- telomeres (7)
- thermodynamics (7)
- thrombo-inflammation (7)
- total hip arthroplasty (7)
- transcriptional regulation (7)
- trial (7)
- variability (7)
- vestibular schwannoma (7)
- virus (7)
- visual system (7)
- wearable (7)
- Übergangsmetalloxide (7)
- Übergewicht (7)
- - (6)
- 18F-FDG (6)
- 2 (6)
- ABA (6)
- ACC (6)
- AMPK (6)
- ANP (6)
- ATLAS <Teilchendetektor> (6)
- Abwehrreaktion (6)
- AdS-CFT-Korrespondenz (6)
- Akustikusneurinom (6)
- Akute Leukämie (6)
- Allergy (6)
- Alpen (6)
- Amino acids (6)
- Amygdala (6)
- Analoga (6)
- Anatolische Sprachen (6)
- Angeborene Immunität (6)
- Angsterkrankungen (6)
- Anionentranslokator (6)
- Antibody (6)
- Antizipation (6)
- Anästhesie (6)
- Aortenaneurysma (6)
- Aortenklappenstenose (6)
- Arbeitsteilung (6)
- Assoziatives Gedächtnis (6)
- Atriales natriuretisches Hormon (6)
- Aufsichtsrat (6)
- Augmentation (6)
- Automation (6)
- B-cell lymphoma (6)
- B7-H1 (6)
- BCI (6)
- BRCA1 (6)
- Beta-Rezeptor (6)
- Bildgebung (6)
- Bilharziose (6)
- Biologische Uhr (6)
- Biology (6)
- Blutstillung (6)
- Borheterocyclen (6)
- Boğazköy (6)
- Bronchialasthma (6)
- CD1d (6)
- CML (6)
- CNTF (6)
- COPD (6)
- CRPS (6)
- Calcineurin (6)
- Campylobacter jejuni (6)
- Candida auris (6)
- Carcinogen (6)
- Cataglyphis (6)
- Chemische Bindung (6)
- Chemotaxis (6)
- Chromatographie (6)
- Chromophor (6)
- Chronophin (6)
- Ciliary neurotrophic factor (6)
- Computational Chemistry (6)
- Cycloaddition (6)
- Cyclodextrine (6)
- DFB-Laser (6)
- DNA binding (6)
- Datenanalyse (6)
- Dehydroepiandrosteron (6)
- Desfluran (6)
- Domäne <Biochemie> (6)
- Dreidimensionale Rekonstruktion (6)
- Drugs (6)
- Dünnschichtsolarzelle (6)
- EBV (6)
- ECM (6)
- EKP (6)
- Earth observation (6)
- Echinococcus multilocularis (6)
- Ecology (6)
- Ehrenamtliche Tätigkeit (6)
- Einkaufszentrum (6)
- Elektroporation (6)
- Enantioselektivität (6)
- Endocytose (6)
- Endodontie (6)
- Endozytose (6)
- Enterobacteriaceae (6)
- Entscheidungsunterstützungssystem (6)
- Entwicklungsländer (6)
- Entwicklungspsychologie (6)
- Fabry (6)
- Fahrerverhalten (6)
- Fanconi Anemia (6)
- Fanconi anemia (6)
- Fas-Ligand (6)
- Fatigue (6)
- Finanzmathematik (6)
- Fn14 (6)
- Formicidae (6)
- Fotoionisation (6)
- Fotophysik (6)
- Fourier-Spektroskopie (6)
- Fragmentation (6)
- Frankreich (6)
- Französisch (6)
- Funktion (6)
- Funktionelle NMR-Tomographie (6)
- GC-MS (6)
- GPVI (6)
- GaAs (6)
- Gammaastronomie (6)
- Gender (6)
- Gentoxizität (6)
- Geobotanik (6)
- Gerste (6)
- Geschlechtsbestimmung (6)
- Gesicht (6)
- Glucose (6)
- Glucosetransportproteine (6)
- Gluino Production (6)
- Glykoproteine (6)
- Glykosylierung (6)
- Gold (6)
- Growth (6)
- Grundschulkind (6)
- HAART (6)
- HBMEC (6)
- HGF (6)
- Hadron colliders (6)
- Halbleiteroberfläche (6)
- Hautbiopsie (6)
- HeLa cells (6)
- Hepatitis C (6)
- Herzkatheter (6)
- Heterocyclische Verbindungen (6)
- Higgs bosons (6)
- Higgs physics (6)
- High throughput screening (6)
- Hochtemperatursupraleiter (6)
- Honeybee (6)
- Hubbard model (6)
- Humanismus (6)
- Hydrogeologie (6)
- Hypertension (6)
- Hypothalamus (6)
- Hypoxia (6)
- Hörgerät (6)
- Hörverlust (6)
- Hüftgelenkprothese (6)
- ICD-10 (6)
- ITS2 (6)
- Imaging (6)
- Immun-Checkpoint (6)
- Immunaktivierung (6)
- Immunoblot (6)
- Immuntoleranz (6)
- Infrarotspektroskopie (6)
- Integration (6)
- Intensivstation (6)
- Interferon <gamma-> (6)
- Interleukin-4 (6)
- IoT (6)
- Juvenile idiopathische Arthritis (6)
- Karriere (6)
- Kation (6)
- Keratinozyt (6)
- Kiefergelenk (6)
- Kinasen (6)
- Knochendichte (6)
- Knochenmark (6)
- Kohlenhydrate (6)
- Komplexität (6)
- Komplexitätstheorie (6)
- Konjugierte Polymere (6)
- Koordinationschemie (6)
- Kostimulation (6)
- Kraniosynostose (6)
- Körperliche Aktivität (6)
- LASP-1 (6)
- LOH (6)
- Ladungstransport (6)
- Large Hadron Collider (6)
- Laserspektroskopie (6)
- Latrophilin (6)
- Learning (6)
- Legionella (6)
- Leistung (6)
- Leonhard classification (6)
- Leonhard-Klassifikation (6)
- Lipide (6)
- Lymphome (6)
- Lymphozyten (6)
- MASS (6)
- MHC (6)
- Magenchirurgie (6)
- Magnetic Resonance Imaging (6)
- Magnetic resonance imaging (6)
- Magnetowiderstand (6)
- Makroökonomie (6)
- Manisch-depressive Krankheit (6)
- Mechanisms (6)
- Medien (6)
- Melanin (6)
- Melanoma (6)
- Membran (6)
- Memory (6)
- Mensch-Maschine-Schnittstelle (6)
- Metabolism (6)
- Metabolomics (6)
- Metagedächtnis (6)
- Metalloproteinasen (6)
- Methylation (6)
- Micronuclei (6)
- Mikrobiologie (6)
- Mikroresonator (6)
- Mitochondria (6)
- Molekulardesign (6)
- Monoklonaler bispezifischer Antikörper (6)
- Montessori (6)
- Morbus Crohn (6)
- Multiple sclerosis (6)
- Mutationsanalyse (6)
- Myatrophische Lateralsklerose (6)
- Mykenische Kultur (6)
- Myocardial infarction (6)
- Myokard (6)
- NLO Computations (6)
- NLRP3 (6)
- NMR spectroscopy (6)
- NRF2 (6)
- Nachhaltigkeitsrecht (6)
- Nachuntersuchung (6)
- Nahrung (6)
- Nanoparticles (6)
- Nasenschleimhaut (6)
- Nationalsozialismus (6)
- Nebennierenkarzinom (6)
- Nebennierenrindeninsuffizienz (6)
- Nebennierentumor (6)
- Nephroblastom (6)
- Neue Medien (6)
- Neugeborene (6)
- Neuroanatomie (6)
- Neurofascin (6)
- Neurologie (6)
- Neuromonitoring (6)
- Nicht-kleinzelliges Bronchialkarzinom (6)
- Nichtlineare Optimierung (6)
- Nickel (6)
- Nickelkomplexe (6)
- Non-coding RNA (6)
- Notfall (6)
- Nucleinsäuren (6)
- Nuklearfaktor Kappa B (6)
- Numerisches Verfahren (6)
- OLED (6)
- Olfaction (6)
- Oncology (6)
- Oozyte (6)
- Opioide (6)
- Optik (6)
- Optogenetics (6)
- PCI (6)
- Paracetamol (6)
- Parkinson disease (6)
- Pathologie (6)
- Peptidsynthese (6)
- Perowskit (6)
- Pflanzengeographie (6)
- Phonologische Bewusstheit (6)
- Phosphane (6)
- Photophysik (6)
- Physikalische Chemie (6)
- Phänotyp (6)
- Plastizität (6)
- Platelet (6)
- Platinkomplexe (6)
- Plattenosteosynthese (6)
- Polymerisation (6)
- Polymerkomplexe (6)
- Porin (6)
- Probiotikum (6)
- Proteasom (6)
- Proteom (6)
- Pulver (6)
- QM/MM (6)
- RNA sequencing (6)
- RNA-binding proteins (6)
- RNAi (6)
- RT-PCR (6)
- Rac1 (6)
- Radioastronomie (6)
- Raf (6)
- Rashba-Effekt (6)
- Reaktive Sauerstoffspezies (6)
- Rechnernetz (6)
- Rechtsprechung (6)
- Religionsunterricht (6)
- Renin-Angiotensin-System (6)
- Resektion (6)
- Resilienz (6)
- Retina (6)
- Rheologie (6)
- Rheumatoid arthritis (6)
- RhoA (6)
- Rhodopsin (6)
- Ribosom (6)
- Risiko (6)
- Routing (6)
- SDN (6)
- SSTR (6)
- Salmonella enterica (6)
- Schrei (6)
- Selbsteinschätzung (6)
- Selen (6)
- Self-assembly (6)
- Semiconductor (6)
- Sensitivität (6)
- Sensor (6)
- Signalkette (6)
- Siliciumkomplexe (6)
- Siloxane (6)
- Skalierung (6)
- Smad (6)
- Small nuclear RNP (6)
- Software (6)
- Sol-Gel (6)
- Solarzelle (6)
- Soziologie (6)
- Sprachentwicklungsstörung (6)
- Sprachtest (6)
- Stickstoffoxidsynthase (6)
- Strahlensensibilität (6)
- Stroma (6)
- Supramolecular Chemistry (6)
- T-lymphocytes (6)
- TAVI (6)
- TGF-beta (6)
- TNF-alpha (6)
- TNFR2 (6)
- Temperatur (6)
- Therapieerfolg (6)
- Thermodynamik (6)
- Thermoregulation (6)
- Tinnitus (6)
- Toleranz (6)
- Tomate (6)
- Transgene Tiere (6)
- Transiente Absorption (6)
- Transkriptom (6)
- Transporter (6)
- Transposon (6)
- Treatment (6)
- Troponin (6)
- Tuberkulose (6)
- UV-VIS-Spektroskopie (6)
- Ultrafast spectroscopy (6)
- Umfrage (6)
- Umweltschutz (6)
- Universitätsbibliothek Würzburg (6)
- VSG (6)
- Valenz <Linguistik> (6)
- Venusfliegenfalle (6)
- Vergleichende politische Wissenschaft (6)
- Verteiltes System (6)
- Virtual Reality (6)
- Virtualisierung (6)
- Virus (6)
- Viskosität (6)
- Wechselwirkung (6)
- Wissen (6)
- Wortschatz (6)
- Wärmeleitfähigkeit (6)
- XPS (6)
- Xenopus laevis (6)
- Zelllinie (6)
- Zellteilung (6)
- Zirkulardichroismus (6)
- acid sphingomyelinase (6)
- actinomycetes (6)
- adenosine (6)
- adsorption (6)
- alignment (6)
- alkaloids (6)
- alternative splicing (6)
- anatomy (6)
- animal behaviour (6)
- anorexia nervosa (6)
- antidepressants (6)
- antimicrobial peptides (6)
- antioxidants (6)
- arthroscopy (6)
- aspergillosis (6)
- aspergillus fumigatus (6)
- astrocytoma (6)
- auditory (6)
- autoimmune disease (6)
- autonomic nervous system (6)
- bacterial pathogens (6)
- basal ganglia (6)
- bee (6)
- behavioral conditioning (6)
- biopsy (6)
- bioreactor (6)
- body weight (6)
- bone regeneration (6)
- brain tumor (6)
- cancer stem cells (6)
- cardiomyocytes (6)
- cardiovascular diseases (6)
- catecholamines (6)
- cell (6)
- cell proliferation (6)
- cement (6)
- cerebellum (6)
- childhood (6)
- chlamydia (6)
- chondrocytes (6)
- circadian rhythm (6)
- circular dichroism (6)
- climate (6)
- clinical study (6)
- co-culture (6)
- comet assay (6)
- competition (6)
- cosmology (6)
- cyclodextrin (6)
- cytokinins (6)
- damage (6)
- deadwood (6)
- democracy (6)
- density functional theory (6)
- dental education (6)
- detoxification (6)
- disability (6)
- down regulation (6)
- drosophila melanogaster (6)
- drugs (6)
- eHealth (6)
- eating disorders (6)
- efficiency (6)
- ejection fraction (6)
- endovascular (6)
- endurance (6)
- energy metabolism (6)
- energy transfer (6)
- engagement (6)
- enzyme (6)
- estrogens (6)
- ethanol (6)
- experience (6)
- exposure (6)
- eye movements (6)
- eye tracking (6)
- eyes (6)
- factor XII (6)
- fear generalization (6)
- fish (6)
- fluorine (6)
- follicular lymphoma (6)
- functional magnetic resonance imaging (6)
- gas phase (6)
- geomorphology (6)
- germinal center (6)
- glaucoma surgery (6)
- global warming (6)
- glucocorticoids (6)
- glutamate (6)
- grazing (6)
- guard cells (6)
- guideline adherence (6)
- heterochromatin (6)
- homogeneous catalysis (6)
- host-pathogen interaction (6)
- hyperexpression techniques (6)
- ideomotor theory (6)
- immune cells (6)
- immune system (6)
- immunity (6)
- impulsivity (6)
- in vitro selection (6)
- incisional hernia (6)
- infectious diseases (6)
- influenza (6)
- information (6)
- infrared spectroscopy (6)
- intraocular pressure (6)
- isolation (6)
- kidneys (6)
- language (6)
- leishmaniasis (6)
- lesions (6)
- lipids (6)
- localization microscopy (6)
- lung fibrosis (6)
- lysosome (6)
- magnetic resonance (6)
- marine sponges (6)
- medaka (6)
- medical education (6)
- medulloblastoma (6)
- meningococcal disease (6)
- miR-21 (6)
- microbiota (6)
- microdialysis (6)
- models (6)
- movement disorders (6)
- murine (6)
- muscarinic receptors (6)
- muscle (6)
- mushroom bodies (6)
- myocarditis (6)
- natural products (6)
- nephrotoxicity (6)
- neurobiology (6)
- neuronal differentiation (6)
- nuclear medicine (6)
- octopamine (6)
- oilseed rape (6)
- organization (6)
- osteogenic differentiation (6)
- osteoinduction (6)
- osteosynthesis (6)
- outcomes (6)
- pathogenesis (6)
- pathways (6)
- periprosthetic infection (6)
- personalized medicine (6)
- phagocytosis (6)
- phenology (6)
- photoluminescence (6)
- phylogenetic trees (6)
- plasma membrane (6)
- polarization (6)
- polycaprolactone (6)
- polymerase chain reaction (6)
- polyneuropathy (6)
- polyphenols (6)
- protease inhibitors (6)
- protein binding (6)
- protein kinase (6)
- psychiatric disorders (6)
- radical (6)
- radiosensitivity (6)
- regenerative medicine (6)
- repair (6)
- retinal pigment epithelium (6)
- risk stratification (6)
- scale (6)
- school (6)
- semiconductor laser (6)
- sensitivity (6)
- sensor (6)
- sequence (6)
- sequence alignment (6)
- siRNA (6)
- signaling pathway (6)
- signalling (6)
- silver (6)
- skeletal muscle (6)
- skin (6)
- skin biopsy (6)
- sleeping sickness (6)
- small interfering RNAs (6)
- social attention (6)
- sol-gel (6)
- solar cells (6)
- solubility (6)
- somatic mutations (6)
- spacer (6)
- spectral karyotyping (6)
- sponges (6)
- states (6)
- stomata (6)
- structural biology (6)
- supersymmetry (6)
- surface (6)
- sustainability (6)
- system (6)
- systems biology (6)
- thermoregulation (6)
- thrombin (6)
- thymoma (6)
- thyroid cancer (6)
- time-resolved spectroscopy (6)
- tissue (6)
- titanium (6)
- tomography (6)
- total synthesis (6)
- training (6)
- transfection (6)
- transition metal (6)
- translational research (6)
- translocation (6)
- tumor immunology (6)
- uveal melanoma (6)
- valence (6)
- volatile anesthetics (6)
- weight loss (6)
- Überlebenszeit (6)
- 19. Jahrhundert (5)
- 3D cell culture (5)
- 3D-Pulverdruck (5)
- 5-HTTLPR (5)
- ABC-Transporter (5)
- ACE-Hemmer (5)
- ACTH (5)
- AFM (5)
- AI (5)
- AMD (5)
- ATP (5)
- Absorptionsspektroskopie (5)
- Abstimmbarer Laser (5)
- Actin-bindende Proteine (5)
- Adenokarzinom (5)
- Adoleszenz (5)
- Adult (5)
- Aggression (5)
- Agonist (5)
- Aktivierung <Chemie> (5)
- Akustikustumor (5)
- Akzeptanz (5)
- Alkine (5)
- Alkoholismus (5)
- Altersversorgung (5)
- Alzheimer (5)
- Angstsensitivität (5)
- Antigenpräsentation (5)
- Antimikrobieller Wirkstoff (5)
- Antioxidantien (5)
- Aquaporin (5)
- Arbeitsmarkt (5)
- Archaeology (5)
- Arthrodese (5)
- Assoziationsstudie (5)
- Augenheilkunde (5)
- Aurora-A (5)
- Ausstellungskatalog (5)
- Autoantigen (5)
- Autoimmunerkrankung (5)
- Automatisierung (5)
- Axon (5)
- B-MYB (5)
- B-cells (5)
- BRAF (5)
- Bcl-2 (5)
- Begabung (5)
- Belastung (5)
- Berechnung (5)
- Beta-1-Rezeptor (5)
- Betriebliche Altersversorgung (5)
- Bewusstsein (5)
- Bildung (5)
- Biofabrication (5)
- Biogenese (5)
- Biologischer Abbau (5)
- Biopsie (5)
- Blei (5)
- Boden (5)
- Bone regeneration (5)
- Borane (5)
- Borate (5)
- Breaking (5)
- Bronzezeit (5)
- Bruschit (5)
- Bruxismus (5)
- C-reactive protein (5)
- CD-Spektroskopie (5)
- CD8 (5)
- CEACAM1 (5)
- CIDP (5)
- CSF (5)
- CYR61 (5)
- Cadmiumselenid (5)
- Camponotus (5)
- Caspasen (5)
- Ceramide (5)
- Channelrhodopsin (5)
- Chemotherapy (5)
- Chiralität (5)
- Cholesterin (5)
- Chronisch thromboembolische pulmonale Hypertonie (5)
- Chronischer Schmerz (5)
- Churriter (5)
- Climate change (5)
- Cochlea (5)
- Cognitive control (5)
- Coherent Multidimensional Spectroscopy (5)
- Colitis ulcerosa (5)
- Computer Center (5)
- Crohn-Krankheit (5)
- CubeSat (5)
- Cuneiform text (5)
- Cystein (5)
- Cytokines (5)
- DNA replication (5)
- DNA-Methylierung (5)
- DNA-Reparatur (5)
- Dark Matter (5)
- Degeneration (5)
- Deletion (5)
- Demökologie (5)
- Development (5)
- Diabetes mellitus Typ 1 (5)
- Diels-Alder reactions (5)
- Differentialgleichung (5)
- Dimension 3 (5)
- Distale Radiusfraktur (5)
- Drahtloses Sensorsystem (5)
- Dystonie (5)
- EHEC (5)
- Earth Observation (5)
- Electron microscopy (5)
- Electrospinning (5)
- Elektronendichte (5)
- Elektronengas (5)
- Embryonale Stammzelle (5)
- Emotionen (5)
- Encephalitis (5)
- Energietransfer (5)
- Energy (5)
- Entscheidung (5)
- Entscheidungsunterstützung (5)
- Entwicklungsbiologie (5)
- Enzyme replacement therapy (5)
- Epigenetic (5)
- Erythropoietin (5)
- Essverhalten (5)
- European Union (5)
- Expositionstherapie (5)
- Extinktion (5)
- FACS (5)
- FGF (5)
- FGFR (5)
- Fahrerassistenzsystem (5)
- Fermionensystem (5)
- Festkörpertheorie (5)
- Film (5)
- Fließregulierung (5)
- Fluoreszenzkorrelationsspektroskopie (5)
- Foamyviren (5)
- Fragmentierung (5)
- Frühdiagnostik (5)
- Funde (5)
- Furchtgeneralisierung (5)
- Furchtkonditionierung (5)
- G-protein (5)
- GDNF (5)
- GFAP (5)
- GWAS (5)
- Gastrointestinaltrakt (5)
- Geburtshilfe (5)
- Gefäßprothese (5)
- Gemeinde (5)
- Gen notch (5)
- Gene (5)
- Gene-expression (5)
- Gentransfer (5)
- Gephyrin (5)
- German as a foreign language (5)
- Gewebedoppler (5)
- Gewebekultur (5)
- Glas (5)
- Glutamattransporter (5)
- Glycinrezeptor (5)
- Governance (5)
- Graph (5)
- Graphenzeichnen (5)
- HLA-G (5)
- HMG-Proteine (5)
- HRV (5)
- HUWE1 (5)
- Halbleiterschicht (5)
- Halbsandwich-Verbindungen (5)
- Hals-Nasen-Ohren-Tumor (5)
- Handelsforschung (5)
- Handlung (5)
- Heilpflanzen (5)
- Heparin (5)
- Hepatitis B (5)
- Hepatozyten-Wachstumsfaktor (5)
- Herzschrittmacher (5)
- Hittites (5)
- Hochauflösendes Verfahren (5)
- Homogene Katalyse (5)
- Hormone (5)
- Humorale Immunität (5)
- Hydroxylapatit (5)
- Hämatopoese (5)
- Hörscreening (5)
- ICD (5)
- IL-2 (5)
- Imatinib (5)
- Immunoassay (5)
- Immunobiologie (5)
- Impurity Profiling (5)
- In-vitro-Kultur (5)
- In-vivo (5)
- InSAR (5)
- Influenza (5)
- Interleukin 2 (5)
- Internationalisierung (5)
- Invasive Aspergillose (5)
- Jasmonsäure (5)
- Judit <Buch> (5)
- Kardiovaskuläres System (5)
- Karl Leonhard (5)
- Kartierung (5)
- Keimzentrum (5)
- Kernproteine (5)
- Kerntransport (5)
- Kidney (5)
- Kinase (5)
- Kinder- und Jugendpsychiatrie (5)
- Kinematik (5)
- Kirche (5)
- Klassische Konditionierung (5)
- Kleinkern (5)
- Klinisches Experiment (5)
- Knorpelzelle (5)
- Kombinationstherapie (5)
- Kombinatorische Synthese (5)
- Komorbidität (5)
- Komorbiditäten (5)
- Komplement (5)
- Komödie (5)
- Kondensierte Materie (5)
- Konsumentenverhalten (5)
- Kontrollierte Wirkstofffreisetzung (5)
- Kontrollierte klinische Studie (5)
- Krankheit (5)
- Krebsforschung (5)
- Kunsterziehung (5)
- Käfer (5)
- Körperliche Leistungsfähigkeit (5)
- LL-37 (5)
- Laktat (5)
- Latenz (5)
- Lautheit (5)
- Learner autonomy (5)
- Lebensmittel (5)
- Leberzellkrebs (5)
- Leberzirrhose (5)
- Lehrerfortbildung (5)
- Lehrmittel (5)
- Leishmania major (5)
- Leistungsdiagnostik (5)
- Lesen (5)
- Lewis-Base (5)
- Linienbandkeramik (5)
- Listeria (5)
- Lung (5)
- MAGIC-Teleskop (5)
- Macaranga (5)
- Magenkrebs (5)
- Magnetischer Halbleiter (5)
- Malaria tropica (5)
- Management (5)
- Manganverbindungen (5)
- Mangelernährung (5)
- Mathematische Modellierung (5)
- Medizingeschichte (5)
- Medulloblastoma (5)
- Meerschweinchen (5)
- Membrantransport (5)
- Messung (5)
- Metabolom (5)
- Metabolomik (5)
- Metagenom (5)
- Metallocenophane (5)
- Metallorganische Polymere (5)
- Metallorganische Verbindungen (5)
- Metallorganisches Netzwerk (5)
- Microtubules (5)
- Migräne (5)
- Mikrokern (5)
- Mikroorganismus (5)
- Mikrotubulus (5)
- Minimal-invasive Chirurgie (5)
- Minoische Kultur (5)
- Mitomycin C (5)
- Monetary Policy (5)
- Monoschicht (5)
- Morphology (5)
- Mouse (5)
- Mozart (5)
- Multiple Sclerosis (5)
- Multiproteinkomplex (5)
- Muskeldystrophie (5)
- Muskelzelle (5)
- Mutationen (5)
- Mutualismus (5)
- Myelom (5)
- Mädchen (5)
- NEXAFS (5)
- NF-AT (5)
- NF-KAPPA-B (5)
- NF-kappaB (5)
- NFκB (5)
- NGA (5)
- NLO computations (5)
- Nachkriegszeit (5)
- Nahfeldoptik (5)
- Nahinfrarotspektroskopie (5)
- Namibia <Nordwest> (5)
- Nanometerbereich (5)
- Nanooptik (5)
- Narbenhernie (5)
- Natriumkanal (5)
- Natural Products (5)
- Naturschutz (5)
- Nebennierenrinde (5)
- Nebenschilddrüse (5)
- Neisseria (5)
- Nekrose (5)
- Nervenfaser (5)
- Neurogenetik (5)
- Neuronales Netz (5)
- Neuropathy (5)
- Neurophysiologie (5)
- Neuroprotektion (5)
- Neurowissenschaften (5)
- Nichtlineare Spektroskopie (5)
- Niederschlag (5)
- Notenbank (5)
- OCD (5)
- OCT (5)
- Oberflächenfunktionalisierung (5)
- Oberflächenverstärkter Raman-Effekt (5)
- Occludin (5)
- Opiatrezeptor (5)
- Optimization (5)
- Optische Fernerkundung (5)
- Orientierung (5)
- Ovarialkarzinom (5)
- P4 (5)
- PALM (5)
- PDE (5)
- PDXP (5)
- PMMA (5)
- Pandemie (5)
- Pankreas (5)
- Parallele Bildgebung (5)
- Patientenverfügung (5)
- Patientenzufriedenheit (5)
- Pentakoordination (5)
- Permeation (5)
- Perovskite (5)
- Perylenbisdicarboximide <Perylen-3,4:9,10-bis(dicarboximide)> (5)
- Perylendianhydrid (5)
- Pflanzenfressende Insekten (5)
- Pharmazie (5)
- Phasenvariation (5)
- Phosphatase (5)
- Phosphatasen (5)
- Phosphine (5)
- Photochemische Reaktion (5)
- Photochemistry (5)
- Photoemission (5)
- Phytoprostane (5)
- Pilze (5)
- Piperidinderivate (5)
- PolSAR (5)
- Politik (5)
- Polymer (5)
- Polyphenole (5)
- Polysomnographie (5)
- Portugiesisch (5)
- Positronen-Emissions-Tomographie (5)
- Posttranskriptionelle Regulation (5)
- Prednisolon (5)
- PrfA (5)
- Primaten (5)
- Projektarbeit (5)
- Propaganda (5)
- Protease (5)
- Protein-Protein-Wechselwirkung (5)
- Proteinkinase A (5)
- Proteinkinasen (5)
- Prothese (5)
- Prothetik (5)
- Prädiktor (5)
- Prädiktoren (5)
- Prävalenz (5)
- Punktmutation (5)
- Pyrolyse (5)
- Pädagogische Psychologie (5)
- Qualitative Inhaltsanalyse (5)
- Qualitätsmanagement (5)
- Quanteninformation (5)
- Quantenkontrolle (5)
- Quantenspinsystem (5)
- Quantitative anatomy (5)
- RADS (5)
- RFID (5)
- RNA polymerase II (5)
- RS-Virus (5)
- RS1 (5)
- RYGB (5)
- Radioiodtherapie (5)
- Randschluss (5)
- Rapid Prototyping (5)
- RapidEye (5)
- Rauchen (5)
- Raumordnung (5)
- Reaktionskinetik (5)
- Reaktionsmechanismus (5)
- Regression (5)
- Regulatory T cells (5)
- Reinheitsanalytik (5)
- Rektumkarzinom (5)
- Reproduktionsmedizin (5)
- Reverse Transkriptase-Polymerase-Kettenreaktion (5)
- Ribavirin (5)
- Risikoanalyse (5)
- Risk (5)
- Roboter (5)
- Rutheniumkomplexe (5)
- Röntgenbeugung (5)
- Röntgenstrahlung (5)
- SLAC1 (5)
- STEC (5)
- Sagittalnahtsynostose (5)
- Salzstress (5)
- Savanne (5)
- Scaffold (5)
- Schlafkrankheit (5)
- Schreiben (5)
- Schulbuch (5)
- Schwamm (5)
- Sekundarstufe (5)
- Selbst (5)
- Selektivität (5)
- Semitistik (5)
- Senile Makuladegeneration (5)
- Septuaginta (5)
- Sequenzanalyse (5)
- Signal transduction (5)
- Silylen (5)
- Skelettmuskel (5)
- Skin (5)
- Software Defined Networking (5)
- Software Engineering (5)
- Sonderpädagogik / Wörterbuch (5)
- Sonderpädagogik / Zeitschrift (5)
- Sonographie (5)
- Spaltöffnung (5)
- Spectroscopy (5)
- Speichel (5)
- Spermatogenese (5)
- Spezifität (5)
- Spin flip (5)
- Sport (5)
- Spred-Proteine (5)
- Stability (5)
- Stadtentwicklung (5)
- Standardmodell <Elementarteilchenphysik> (5)
- Standortplanung (5)
- Standortpolitik (5)
- Staphylococcus epidermidis (5)
- Startle (5)
- Stem cells (5)
- Stereochemie (5)
- Sterilität (5)
- Stimulation (5)
- Strahlungstransport (5)
- Strain (5)
- Streptococcus pneumoniae (5)
- Streptomyces (5)
- Structural Biology (5)
- Struktur-Aktivitäts-Beziehung (5)
- Studium (5)
- Supraleiter (5)
- Symmetrie (5)
- Synapsin (5)
- Synaptonemalkomplex (5)
- Synthesediamant (5)
- Systemtheorie (5)
- TKI (5)
- TLR4 (5)
- TMJ (5)
- TNF-α (5)
- TP53 (5)
- Targeted drug delivery (5)
- Taxonomie (5)
- TerraSAR-X (5)
- Textlinguistik (5)
- Theoretical Chemistry (5)
- Theoretische Informatik (5)
- Theoretische Physik (5)
- Therapeutic Drug Monitoring (5)
- Thrombozytenaggregation (5)
- Titandioxid (5)
- Top physics (5)
- Top quark (5)
- Totalendoprothese (5)
- Toxin (5)
- Tragödie (5)
- Transformation (5)
- Transportprozess (5)
- Triarylamine (5)
- Tumorsuppressorgen (5)
- Tumortherapie (5)
- Ugarit (5)
- Ultraschallkardiographie (5)
- Umwelt (5)
- Ungleichheit (5)
- Unterkiefer (5)
- Urämie (5)
- VE-Cadherin (5)
- Vaccination (5)
- Vaccine (5)
- Vaccinia virus (5)
- Validation (5)
- Vaskularisierung (5)
- Venlafaxin (5)
- Ventilation (5)
- Verarbeitungsflüssigkeit (5)
- Verbundfestigkeit (5)
- Visualization (5)
- Visuelle Wahrnehmung (5)
- Wachstumsfaktor (5)
- Wasserstoffbrückenbindung (5)
- Wettbewerb (5)
- Wortbildung (5)
- Würzburger Hörfeld (5)
- XMCD (5)
- XRD (5)
- Yersinia enterocolitica (5)
- Zea mays (5)
- Zebrafisch (5)
- Zebrafish (5)
- Zink (5)
- Zucker (5)
- accuracy (5)
- acoustic neuroma (5)
- acute heart failure (5)
- adalimumab (5)
- adenocarcinoma (5)
- akute Herzinsuffizienz (5)
- alcohol (5)
- algorithms (5)
- allosteric modulation (5)
- amino acid (5)
- amplification (5)
- angiography (5)
- annotation (5)
- anthocyanins (5)
- anticipation (5)
- anticoagulation (5)
- antigenic variation (5)
- antimicrobial stewardship (5)
- antimicrobials (5)
- aorta (5)
- arousal (5)
- arrhythmia (5)
- arthritis (5)
- augmented reality (5)
- autoantibody (5)
- back pain (5)
- bioink (5)
- bioisosterism (5)
- biokinetics (5)
- biological locomotion (5)
- biomaterials (5)
- biophysics (5)
- bismuth (5)
- blood-brain-barrier (5)
- bond activation (5)
- boronate esters (5)
- brain computer interface (5)
- bronchopulmonary dysplasia (5)
- burden (5)
- caloric restriction (5)
- candidate gene (5)
- carcinomas (5)
- cardiac (5)
- cardioprotection (5)
- cardiovascular (5)
- cardiovascular events (5)
- cardiovascular risk factors (5)
- cartilage regeneration (5)
- cell cultures (5)
- cell cycle and cell division (5)
- cell differentiation (5)
- ceramides (5)
- cerebral ischemia (5)
- chemical communication (5)
- chemical ecology (5)
- chemokine (5)
- child (5)
- chirality (5)
- ciliary neurotrophic factor (5)
- cisplatin (5)
- clinical trials (5)
- cloning (5)
- collagens (5)
- colon cancer (5)
- comorbidity (5)
- complement (5)
- condensed matter physics (5)
- congestive heart failure (5)
- contrast agent (5)
- coronavirus (5)
- costimulation (5)
- creatine kinase (5)
- critical illness (5)
- cross-coupling (5)
- demyelination (5)
- dendritische Zelle (5)
- dentate gyrus (5)
- dexamethasone (5)
- diborene (5)
- discourse analysis (5)
- docking (5)
- driving simulation (5)
- drug discovery (5)
- ecological momentary assessment (5)
- elderly (5)
- electrochemistry (5)
- electrospinning (5)
- embryo (5)
- emission (5)
- empathy (5)
- encephalitis (5)
- end-stage renal disease (5)
- endoscopy (5)
- endothelial dysfunction (5)
- endothelial progenitor cells (5)
- environment (5)
- enzyme-linked immunoassays (5)
- enzymes (5)
- epithelial-mesenchymal transition (5)
- erythropoietin (5)
- estrogen (5)
- excitons (5)
- experimental design (5)
- eye-tracking (5)
- fatty acids (5)
- fibroblasts (5)
- fibromyalgia (5)
- flagella (5)
- fluorescence imaging (5)
- fluorescence resonance energy transfer (5)
- food security (5)
- food-cues (5)
- forensic neuropathology (5)
- fusion (5)
- gait (5)
- galactomannan (5)
- gametogenesis (5)
- gender differences (5)
- gene targeting (5)
- gene-expression (5)
- generation (5)
- genotype (5)
- giant cell arteritis (5)
- glycolysis (5)
- glycoprotein VI (5)
- gp130 (5)
- graph drawing (5)
- hearing loss (5)
- heat transfer (5)
- hematopoietic stem cells (5)
- history (5)
- homeostasis (5)
- honeybees (5)
- hospitalization (5)
- human-computer interaction (5)
- hydroboration (5)
- hyperekplexia (5)
- hypertrophy (5)
- immunization (5)
- implementation (5)
- in situ hybridization (5)
- in vitro model (5)
- infarction (5)
- infections (5)
- inflammasome (5)
- inflammatory pain (5)
- inhibitors (5)
- innovation (5)
- insulin resistance (5)
- integration (5)
- integrin (5)
- intestinal epithelial barrier (5)
- intestine (5)
- ion channel (5)
- iron oxide nanoparticles (5)
- irradiation (5)
- jasmonates (5)
- keratinocytes (5)
- kinematics (5)
- knee arthroplasty (5)
- lactate (5)
- land cover (5)
- language acquisition (5)
- larvae (5)
- late enhancement (5)
- lipid rafts (5)
- long-term outcome (5)
- longitudinal study (5)
- loss of heterozygosity (5)
- loudness (5)
- magnetism (5)
- masked priming (5)
- mast cells (5)
- mechanical thrombectomy (5)
- medical rehabilitation (5)
- megakaryocyte (5)
- mental disorders (5)
- mesenchymal stem cell (5)
- metabolic syndrome (5)
- microglomeruli (5)
- microsatellite instability (5)
- migraine (5)
- mineralization (5)
- minimal invasiv (5)
- mobility (5)
- modelling (5)
- molecular medicine (5)
- molecular neuroscience (5)
- morbidity (5)
- motoneurons (5)
- motor control (5)
- movement ecology (5)
- music (5)
- mycotoxin (5)
- nano (5)
- nanostructures (5)
- naphthylisoquinoline alkaloids (5)
- natural disturbance (5)
- neisseria meningitidis (5)
- nephroblastoma (5)
- network (5)
- neuroanatomy (5)
- neuroethology (5)
- neuromelanin (5)
- neuronal plasticity (5)
- neuropeptides (5)
- neuropsychiatric disorders (5)
- neurotrophic factor (5)
- newborn hearing screening (5)
- nickel (5)
- nitric oxide synthase (5)
- norepinephrine (5)
- nucleolus (5)
- nutrients (5)
- object detection (5)
- oncolysis (5)
- organic semiconductor (5)
- organic synthesis (5)
- organische Halbleiter (5)
- osteoblasts (5)
- parasitic diseases (5)
- parathyroid hormone (5)
- patch-clamp (5)
- pathogenicity (5)
- peptide (5)
- perception and action (5)
- persistence (5)
- pharmacokinetic (5)
- phase variation (5)
- phylogenetic analysis (5)
- physiology (5)
- plant-insect interactions (5)
- plants (5)
- plasma cells (5)
- polyomavirus (5)
- population pharmacokinetics (5)
- porin (5)
- power (5)
- predictors (5)
- promoter (5)
- prostate-specific membrane antigen (5)
- protein expression (5)
- psychiatry (5)
- psychological distress (5)
- pyrolysis (5)
- quality (5)
- quantum optics (5)
- qubit (5)
- radial (5)
- reactive intermediates (5)
- receptor tyrosine kinase (5)
- recombinant proteins (5)
- refractory (5)
- regeneration (5)
- regression analysis (5)
- renal cell carcinoma (5)
- renal function (5)
- resin (5)
- resolution (5)
- response inhibition (5)
- resveratrol (5)
- retinoic acid (5)
- retrospective (5)
- revision (5)
- reward (5)
- ring-opening polymerization (5)
- rotator cuff tear (5)
- ruthenium (5)
- saliva (5)
- sarcopenia (5)
- seasonality (5)
- self (5)
- self-organization (5)
- sevoflurane (5)
- shock (5)
- single-crystal X-ray study (5)
- skin punch biopsy (5)
- soil (5)
- somatostatin receptor (5)
- soziale Insekten (5)
- soziale Kompetenz (5)
- specificity (5)
- spider phobia (5)
- spiders (5)
- spin (5)
- spinal cord (5)
- splicing (5)
- stability (5)
- startle disease (5)
- stem-cell transplantation (5)
- structural elucidation (5)
- subarachnoid hemorrhage (5)
- subtypes (5)
- sucrose (5)
- sudden cardiac death (5)
- super-resolution (5)
- surfactants (5)
- sympathetic nervous system (5)
- symptoms (5)
- synaptic proteins (5)
- synaptic vesicles (5)
- synchrotron radiation (5)
- teaching (5)
- teeth (5)
- telemedicine (5)
- testosterone (5)
- text comprehension (5)
- tight junction (5)
- transcranial direct current stimulation (5)
- transformation (5)
- transgenic mice (5)
- transporter (5)
- transverse momentum (5)
- tremor (5)
- tsetse fly (5)
- tuberculosis (5)
- tumor necrosis factor (5)
- tumour (5)
- ubiquitination (5)
- uremic toxins (5)
- vancomycin (5)
- variants (5)
- vascularization (5)
- vasculitis (5)
- ventilation (5)
- violence (5)
- virtual screening (5)
- virulence factors (5)
- visualization (5)
- voluntary service (5)
- well-being (5)
- wild bees (5)
- winter wheat (5)
- wissenschaftlicher Nachwuchs (5)
- women (5)
- xx (5)
- zwitterionic (5)
- Ägäische Kultur (5)
- Ökonometrie (5)
- Überlebensrate (5)
- γ-H2AX (5)
- --- (4)
- 3D Printing (4)
- 3D reconstruction (4)
- 5-Fluorouracil (4)
- ACL (4)
- AGN (4)
- ANCA (4)
- APOBEC3G (4)
- ASSR (4)
- AVHRR (4)
- Ablösung (4)
- Abwehr (4)
- Accounting (4)
- Acyrthosiphon pisum (4)
- AdS-CFT Correspondence (4)
- AdS/CFT (4)
- Addukt (4)
- Adenoviren (4)
- Adenylate cyclase (4)
- Adjuvans (4)
- Adrenocortical Carcinoma (4)
- Adsorbat (4)
- Aerogel (4)
- Ag(111) (4)
- Agoraphobie (4)
- Agrobacterium tumefaciens (4)
- Akromioklavikulargelenk (4)
- Aktionsforschung (4)
- Aktive Zone (4)
- Alkalische Phosphatase (4)
- Alkoholabhängigkeit (4)
- Alternative Medizin (4)
- Alterung (4)
- Altes Testament (4)
- Aluminiumarsenid (4)
- Alveoläre Echinokokkose (4)
- Alzheimers disease (4)
- Ameise (4)
- Amplifikation (4)
- Analgesie (4)
- Analysis (4)
- Anandamid (4)
- Anaphylaxis (4)
- Ancistrocladus (4)
- Aneuploidie (4)
- Aneurysma (4)
- Anfangsunterricht (4)
- Angewandte Psychologie (4)
- Angiogenesis (4)
- Animal model (4)
- Anionenkanal (4)
- Annotation (4)
- Antarctica (4)
- Antennallobus (4)
- Anthropogene Klimaänderung (4)
- Anthropogener Einfluss (4)
- Antidepressiva (4)
- Antigen CD4 (4)
- Antigen CD44 (4)
- Antigen CD95 (4)
- Antike (4)
- Antimykotikum (4)
- Antioxidans (4)
- Ants (4)
- Anura (4)
- Appendizitis (4)
- Approximationsalgorithmus (4)
- Aroma (4)
- Assoziation (4)
- Astrozytom (4)
- Atemwegsinfektion (4)
- Atlas detector (4)
- Augmented Reality (4)
- Autonomie (4)
- Autophagy (4)
- Avidität (4)
- Aziridine (4)
- B cell (4)
- B chromosomes (4)
- B lymphocytes (4)
- B-Lymphozyten (4)
- B-lymphocytes (4)
- BCG (4)
- BERAphon® (4)
- BMD (4)
- BRET (4)
- Bacillus subtilis (4)
- Bank (4)
- Barth syndrome (4)
- Basaliom (4)
- Bauchfellentzündung (4)
- Begrenzte Staatlichkeit (4)
- Behavior (4)
- Beschaffung (4)
- Bestäubung (4)
- Betriebswirtschaftslehre (4)
- Bevacizumab (4)
- Bewegungssteuerung (4)
- Bienen <Familie> (4)
- Bilanzpolitik (4)
- Bildanalyse (4)
- Bilderzeugung (4)
- Biofilmbildung (4)
- Biophysik (4)
- Bioreaktor (4)
- Bipolar disorder (4)
- Bismut (4)
- Bisphosphonate (4)
- Blasenkrebs (4)
- Blattkäfer (4)
- Blutgefäß (4)
- Bodenerosion (4)
- Borneo (4)
- Borrelia (4)
- Bortezomib (4)
- Borylation (4)
- Borylen (4)
- Borylgruppe (4)
- Borylkomplexe (4)
- Boson (4)
- Breast cancer (4)
- Brief (4)
- Burkholderia pseudomallei (4)
- Bypass (4)
- Bypassoperation (4)
- C-C coupling (4)
- C-MYC (4)
- C. elegans (4)
- CAPM (4)
- CCI (4)
- CD150 (4)
- CD28 Superagonist (4)
- CD44 (4)
- CMR (4)
- CNV (4)
- CPT (4)
- CRP (4)
- CT angiography (4)
- CTLA-4 (4)
- CVID (4)
- Cancer genetics (4)
- Capital-Asset-Pricing-Modell (4)
- Carben (4)
- Carcinogenesis (4)
- Carotisstenose (4)
- Catecholamine (4)
- Cell culture (4)
- Central Asia (4)
- Cephalometry (4)
- Channelrhodopsin-2 (4)
- Charged Aerosol Detection (4)
- Chemische Reinheit (4)
- Chemische Ökologie (4)
- Chemistry (4)
- Chemometrie (4)
- Chloroquin (4)
- Chorioamnionitis (4)
- Chromosomenaberration (4)
- Climate Change (4)
- Clopidogrel (4)
- Cluster-Analyse (4)
- Computerunterstütztes Lernen (4)
- Conditioning (4)
- Corporate Governance (4)
- Costa Rica (4)
- Craniosynostosis (4)
- Crowdsourcing (4)
- Cushing-Syndrom (4)
- Cushing’s syndrome (4)
- Cyanoborate (4)
- Cyclodextrin (4)
- Cyclophane (4)
- Cyclovoltammetrie (4)
- DCF (4)
- DCM (4)
- DFT calculations (4)
- DHEAS (4)
- DNA transcription (4)
- DNA-Replikation (4)
- DNA-Schaden (4)
- DNA-binding proteins (4)
- DNS-Bindung (4)
- DRG (4)
- Darmflora (4)
- Darmkrebs (4)
- Dasatinib (4)
- Demokratie (4)
- Dendritic cell (4)
- Dentalkeramik (4)
- Design (4)
- Desmosom (4)
- Dexamethason (4)
- Diabetische Polyneuropathie (4)
- Diagnosis (4)
- Diborane(4) (4)
- Dictyostelium discoideum (4)
- Dienstgüte (4)
- Differentiation (4)
- Diffusions-MRT (4)
- Diffusionsverfahren <Halbleitertechnologie> (4)
- Digital Storytelling (4)
- Dimension 2 (4)
- Dimere (4)
- Dipolare Cycloaddition (4)
- Distributions (4)
- Diversity (4)
- Docetaxel (4)
- Doppelbindung (4)
- Drama (4)
- Duftstoff (4)
- Dunkle Materie (4)
- Duplikation (4)
- Dynamics (4)
- ECG (4)
- EGF (4)
- EKG (4)
- EPR (4)
- Echtzeit (4)
- Effizienz (4)
- Eisenkomplexe (4)
- Eisenoxide (4)
- Electronic Commerce (4)
- Electroweak interaction (4)
- Elektrocochleographie (4)
- Elektromyographie (4)
- Elektronenspektroskopie (4)
- Elektronentransport (4)
- Elektrospinnen (4)
- Elliptische Differentialgleichung (4)
- Emotionserkennung (4)
- Endoprothese (4)
- Endosymbiont (4)
- Endothelbarriere (4)
- Endotheldysfunktion (4)
- Endothelium (4)
- Enrichement (4)
- Entstehung (4)
- Enzymersatztherapie (4)
- Ependymom (4)
- Epigenetics (4)
- Epitaxie (4)
- Epitaxy (4)
- Ereigniskorrelierte Potentiale (4)
- Erfahrung (4)
- Erhebungsinstrumente (4)
- Erwachsenenbildung (4)
- Erzählen (4)
- Essgewohnheit (4)
- Estradiol (4)
- Ethanol (4)
- Ethnografie (4)
- Euler equations (4)
- Europäische Zentralbank (4)
- Excitons (4)
- Expansion Microscopy (4)
- Extrakt (4)
- Extremwerttheorie (4)
- FDG (4)
- FSHD (4)
- Fahren (4)
- Fahrsimulation (4)
- Fake News (4)
- Fazialisparese (4)
- Feldeffekttransistor (4)
- Feminismus (4)
- Fertilität (4)
- Fettleber (4)
- Fettsäurestoffwechsel (4)
- Fettzelle (4)
- Fibroblasts (4)
- Finanzkrise (4)
- First Responder (4)
- Fließregulierungsmittel (4)
- Fluorescence Microscopy (4)
- Foamyvirus (4)
- Follikuläres Lymphom (4)
- Fortpflanzungsverhalten (4)
- Fotokatalyse (4)
- Foxp3 (4)
- Friedrich (4)
- Frühe Neuzeit (4)
- Fullerene (4)
- Funktionswerkstoff (4)
- G protein-coupled receptors (4)
- G proteins (4)
- G-Protein gekoppelte Rezeptor (4)
- G-Protein gekoppelter Rezeptor (4)
- GC-A (4)
- GVHD (4)
- Galliumarsenid-Bauelement (4)
- Galliumarsenidlaser (4)
- Gasionisationsdetektor (4)
- Gedächtnisbildung (4)
- Geflüchtete (4)
- Geisteswissenschaften (4)
- Geißel <Biologie> (4)
- Gelatine (4)
- Gelingensbedingungen (4)
- Gene regulation (4)
- Generalisierung (4)
- Genomschaden (4)
- Geobotanik ; Pflanzengeographie (4)
- Geophysik (4)
- Gesichtsschmerz (4)
- Gesprochene Sprache (4)
- Gesundheitsförderung (4)
- Gesundheitswesen (4)
- Glatte Muskulatur (4)
- Glioma (4)
- Glucocorticosteroidrezeptor (4)
- Glucosestoffwechsel (4)
- Glutamatrezeptor (4)
- Glutamin (4)
- Glutathion (4)
- Graphene (4)
- Griechenland <Altertum> (4)
- Grundwasserneubildung (4)
- Grün fluoreszierendes Protein (4)
- Guanidinderivate (4)
- GvHD (4)
- Gynäkologie (4)
- HFmrEF (4)
- HSM-sentence-test (4)
- Haftung (4)
- Halbleiterphysik (4)
- Hall, Stuart (4)
- Halothan (4)
- Handchirurgie (4)
- Handgelenk (4)
- Harnblasenkarzinom (4)
- Hautkrebs (4)
- Helicobacter (4)
- Hepatozelluläres Karzinom (4)
- Herstellung (4)
- Herzfunktion (4)
- Heterocyclen (4)
- Heubacillus (4)
- Hieracium (4)
- Hierarchy (4)
- Higgs (4)
- Hirnödem (4)
- Histone (4)
- Histopathologie (4)
- Hochschule (4)
- Hochtemperatursupraleitung (4)
- Hornhaut (4)
- Hospitalismus <Hygiene> (4)
- Hsp90 (4)
- Hybridpolymer (4)
- Hybridpolymere (4)
- Hydrodynamik (4)
- Hydrolyse (4)
- Hyperaldosteronismus (4)
- Hypertrophische Herzmuskelkrankheit (4)
- Hyponatriämie (4)
- Hypoparathyreoidismus (4)
- Hypophosphatasia (4)
- Hämodynamik (4)
- Hämophilie A (4)
- Höhengradient (4)
- Höherkoordination (4)
- Hörstörung (4)
- Hörtest (4)
- Hüfte (4)
- Hüftendoprothetik (4)
- ICSI (4)
- IL-6 (4)
- IMRT (4)
- Identifizierung (4)
- Illustration (4)
- Image Processing (4)
- Immunität <Medizin> (4)
- Immunstimulation (4)
- Implantierbarer Kardioverter-Defibrillator (4)
- Inanspruchnahme (4)
- Infektionskrankheit (4)
- Informationskompetenz (4)
- Infrarot (4)
- Inhalation (4)
- Innate immunity (4)
- Insekt (4)
- Instabilität (4)
- Insulin-like Growth Factor I (4)
- Interaktionen (4)
- Interkulturelles Lernen (4)
- Interleukin 1-beta (4)
- Interleukin 13 (4)
- Interleukin 8 (4)
- Internationalität (4)
- Internet der Dinge (4)
- Internet of Things (4)
- Invertase (4)
- Ionic Liquids (4)
- Ionisierende Strahlung (4)
- Iridiumkomplexe (4)
- Ischämische Präkonditionierung (4)
- Isolation (4)
- JIA (4)
- Japan (4)
- Judith <Book> (4)
- Jura (4)
- Jura <Geologie> (4)
- Kalium (4)
- Kalorimetrie (4)
- Karoo (4)
- Karst (4)
- KasA (4)
- Katalog (4)
- Kaufverhalten (4)
- Kilimandscharo (4)
- Kinder und Jugendliche (4)
- Kindergarten (4)
- Kinderpsychiatrie (4)
- Kindesalter (4)
- Klausur (4)
- Klonierung (4)
- Knie (4)
- Knochenbildung (4)
- Knochenkleber (4)
- Knochenzemente (4)
- Knorpelregeneration (4)
- Kohlenmonoxid (4)
- Kohärente Kontrolle (4)
- Kombinatorik (4)
- Kongestive Herzmuskelkrankheit (4)
- Kontinentales Tiefbohrprogramm (4)
- Koordinationsverbindungen (4)
- Koordinativ ungesättigte Verbindungen (4)
- Korrosion (4)
- Kosmologie (4)
- Kosten (4)
- Kraftmikroskopie (4)
- Kraniometrie (4)
- Krankheitsverarbeitung (4)
- Krebstherapie (4)
- Kreuzreaktion (4)
- Kristallisation (4)
- Kristallwachstum (4)
- Kupfer (4)
- LC/MS (4)
- LINC complex (4)
- Lactate (4)
- Lagerungsplagiozephalus (4)
- Lamina (4)
- Lamine (4)
- Laminin (4)
- Langerhans cells (4)
- Langfristige Prognose (4)
- Laparoskopie (4)
- Laufzeit (4)
- Lebensalter (4)
- Leberresektion (4)
- Legionärskrankheit (4)
- Leistungssport (4)
- Lepidoptera (4)
- Leptin (4)
- Lernerfolg (4)
- Lernpsychologie (4)
- Lernverhalten (4)
- Leukozyt (4)
- Leukämie (4)
- Lewis acids (4)
- Lewis-Säure (4)
- Localization (4)
- Lopinavir (4)
- Loss of heterozygosity (4)
- Low-density-Lipoproteine (4)
- Lung cancer (4)
- Lungenembolie (4)
- Lymphknoten (4)
- Lymphogranulomatose (4)
- Lysosom (4)
- MALDI-MS (4)
- MALT (4)
- MCP-1 (4)
- MIBG (4)
- MIZ1 (4)
- MMB (4)
- MMP (4)
- MPEC (4)
- MPFL (4)
- MR (4)
- MR-Spektroskopie (4)
- MSCs (4)
- MTUS1 (4)
- Macrophages (4)
- Magnetoelektronik (4)
- Magnetpartikelbildgebung (4)
- Maisstärke (4)
- Malignes Lymphom (4)
- Mammographie (4)
- Massenmedien (4)
- Mechanismus (4)
- Medaka (4)
- Mediendidaktik (4)
- Medienkritik (4)
- Medienpädagogik (4)
- Mehrkriterielle Optimierung (4)
- Melodie (4)
- Mensch-Maschine-Interaktion (4)
- Menschenrechte (4)
- Mergers and Acquisitions (4)
- Mesenchymale Stammzelle (4)
- Mesopotamien (4)
- Metabolisches Syndrom (4)
- Metabolit (4)
- Metallosupramolekulare Chemie (4)
- Metamorphose <Geologie> (4)
- Metformin (4)
- Mexiko (4)
- Microglia (4)
- Mikroarray (4)
- Mikrodialyse (4)
- Mikropartikel (4)
- Mikrosatelliteninstabilität (4)
- Mitotane (4)
- Mittelohr (4)
- Mixed Reality (4)
- Mixed-Methods (4)
- Miz1 (4)
- Mobilität (4)
- Modeling (4)
- Modelling (4)
- Models (4)
- Molekulare Bildgebung (4)
- Molekülphysik (4)
- Molybdän (4)
- Morbidität (4)
- Morbus Alzheimer (4)
- Mortality (4)
- Motorische Endplatte (4)
- Multidrug-Resistenz (4)
- Mund-Kiefer-Gesichts-Chirurgie (4)
- Mundhöhlenkarzinom (4)
- Muskel (4)
- Muskelatrophie (4)
- Mustererkennung (4)
- Mutagenese (4)
- Myasthenia gravis (4)
- Mycobacterium tuberculosis (4)
- Myelin (4)
- Mykobakterien (4)
- Mykose (4)
- Mäuse (4)
- NAD (4)
- NASH (4)
- NET (4)
- NF-kappa-B (4)
- NF-κB (4)
- NFkB (4)
- NFkappaB (4)
- NGF (4)
- NGS (4)
- NMDA-Rezeptor (4)
- NPY (4)
- NaV1.9 (4)
- Nanoröhre (4)
- Naphthylisochinolin-Alkaloide (4)
- Narkose (4)
- Natur (4)
- Natural products (4)
- Nausea (4)
- Navigation (4)
- Nebenniereninsuffizienz (4)
- Nebenwirkung (4)
- Nebenwirkungen (4)
- Nephrotoxizität (4)
- Nervennetz (4)
- Nestbau (4)
- Netzwerkanalyse (4)
- Neugeborenenhörscreening (4)
- Neurochirurgie (4)
- Neuromelanin (4)
- Neurons (4)
- Neuropeptide (4)
- Neurospora crassa (4)
- Neurotrophic factors (4)
- Neutrophiler Granulozyt (4)
- Nibelungenlied (4)
- Nichtglatte Optimierung (4)
- Nickelverbindungen (4)
- Nicotiana tabacum (4)
- Niederdimensionaler Halbleiter (4)
- Nitratreduktase (4)
- Nonlinear Dynamics (4)
- Numerisches Modell (4)
- Oberflächenzustand (4)
- Oligomere (4)
- Oligomerisation (4)
- Omarthrose (4)
- Online-Handel (4)
- Onlinehandel (4)
- OpenSpaceAlps (4)
- Operationstechnik (4)
- Optical spectroscopy (4)
- Organic Chemistry (4)
- Organischer Feldeffekttransistor (4)
- Organoid (4)
- Ormocer (4)
- Orthopädie (4)
- Osteoblasten (4)
- Osteoinduction (4)
- Osteopontin (4)
- Osteotomie (4)
- Overlay-Netz (4)
- Oxidative Stress (4)
- Oxidative stress (4)
- PAK (4)
- PBMC (4)
- PEG (4)
- PER (4)
- PI3K (4)
- PSA (4)
- PSMA-RADS (4)
- PTCA (4)
- PTCDA (4)
- PTEN (4)
- PTH (4)
- Paläoklima (4)
- Palökologie (4)
- Parallelkorpus (4)
- Partielle Differentialgleichung (4)
- Pathogenitätsinsel (4)
- Pathogens (4)
- Pathway (4)
- Patient (4)
- Patienten (4)
- Pe (4)
- Perception (4)
- Performance (4)
- Periphere Stammzellentransplantation (4)
- Peripheres Nervensystem (4)
- Perylene Bisimide (4)
- Pflanzeninhaltsstoff (4)
- Pharmacokinetics (4)
- Phasenumwandlung (4)
- Phenomenology (4)
- Pheromone (4)
- Philosophie (4)
- Phobie (4)
- Phosphatidylinositolkinase <Phosphatidylinositol-3-Kinase> (4)
- Phosphoglykolatphosphatase (4)
- Phospholipide (4)
- Phosphor (4)
- Photorezeptor (4)
- Photostrom (4)
- Phthalocyanin (4)
- Physikalische Eigenschaft (4)
- Phänologie (4)
- Phäochromozytom (4)
- Placebo (4)
- Plants (4)
- Plasmon (4)
- Pleuraempyem (4)
- Pollination (4)
- Polyadenylierung (4)
- Polyethylenglykole (4)
- Pontryagin maximum principle (4)
- Prehistory (4)
- Prescriptive Analytics (4)
- Priming (4)
- Prion (4)
- Private Altersversorgung (4)
- Promotor <Genetik> (4)
- Propriozeption (4)
- Prosodie (4)
- Prostaglandin E2 (4)
- Prostata (4)
- Protein-Protein-Interaktion (4)
- Proteinfaltung (4)
- Proteininteraktion (4)
- Proteinkinase B (4)
- Proteinsynthese (4)
- Proteintyrosinphosphatase (4)
- Präparation (4)
- Pseudomonas (4)
- Psychische Gesundheit (4)
- Psychobiologie (4)
- Pulswellengeschwindigkeit (4)
- Punktion (4)
- Punktwolke (4)
- Puppenhandillusion (4)
- Pyridoxalphosphat (4)
- QSAR (4)
- QoE (4)
- Quadrocopter (4)
- Quality of Life (4)
- Quantendraht (4)
- Quantenfeldtheorie (4)
- Quantenkaskadenlaser (4)
- RCT (4)
- RIXS (4)
- RNA modification (4)
- RNA-Seq (4)
- RNS-Bindungsproteine (4)
- RSK (4)
- RZUW (4)
- Rachitis (4)
- Radioonkologie (4)
- Randqualität (4)
- Rashba effect (4)
- Raumwahrnehmung (4)
- Recht (4)
- Rechtsmedizin (4)
- Regelung (4)
- Regenwald (4)
- Register (4)
- Registrierung <Bildverarbeitung> (4)
- Regressionsanalyse (4)
- Regulatorische T-Zellen (4)
- Reifung (4)
- Rekrutierung (4)
- Relaxation (4)
- Relaxationszeit (4)
- Remote sensing (4)
- Renormierungsgruppe (4)
- Repräsentation (4)
- Ressourcenmanagement (4)
- Reverse Transkriptase (4)
- Rhabdomyosarkom (4)
- Rheumatismus (4)
- Rho-Proteine (4)
- Robotics (4)
- Romanische Sprachen (4)
- Rotatorenmanschettenruptur (4)
- Roux-en-Y gastric bypass surgery (4)
- Ruthenium complexes (4)
- Röntgen-Kleinwinkelstreuung (4)
- Röntgendiffraktometrie (4)
- SAS <Programm> (4)
- SLC2A3 (4)
- SOAT1 (4)
- SOX9 (4)
- SPRED2 (4)
- SQH method (4)
- Saccharose (4)
- Sahara (4)
- Sahel (4)
- Salmonella Typhimurium (4)
- Salzhydratschmelze (4)
- Sap47 (4)
- Sauerstoff (4)
- Schaf (4)
- Schlaf (4)
- Schnarchen (4)
- Schulklasse (4)
- Schulterendoprothetik (4)
- Schwein (4)
- Schweiz (4)
- Schwere-Fermionen-System (4)
- Schüler (4)
- Score (4)
- Sekundärkrankheit (4)
- Sekundärprävention (4)
- Sekundärstruktur (4)
- Selbstassemblierung (4)
- Selenoproteine (4)
- Sensitivity (4)
- Serum (4)
- Sevofluran (4)
- Sex determination (4)
- Signaling (4)
- Silanole (4)
- Silicone (4)
- Silikon (4)
- Simulator (4)
- Sintern (4)
- SnRK1 (4)
- Social Media (4)
- Softwareentwicklung (4)
- Soziale Wahrnehmung (4)
- Sozialphilosophie (4)
- Speicheldrüse (4)
- Spessart (4)
- Sphingolipidstoffwechsel (4)
- Sphingomyelinphosphodiesterase (4)
- Sponges (4)
- Sprachverständnistest (4)
- Staatliche Museen zu Berlin. Antikensammlung (4)
- Stabilisierung (4)
- Standortfaktor (4)
- Staphylococcus epidermis (4)
- Statine (4)
- Stereoselektivität (4)
- Stereotyp (4)
- Steuern (4)
- Stickstoff (4)
- Stimme (4)
- Strategie (4)
- Stratigraphie (4)
- Straßenverkehr (4)
- Stressinkontinenz (4)
- Strukturanalyse (4)
- Störgeräusch (4)
- Supramolekulare Struktur (4)
- Surgery (4)
- Synapsine (4)
- Synaptonemal complex (4)
- Synuclein <alpha-> (4)
- System (4)
- Systematische Übersichtsarbeit (4)
- T Zellen (4)
- T-Zell-Aktivierung (4)
- T-Zell-Lymphom (4)
- T-cell (4)
- TFIIH (4)
- TNAP (4)
- TNF receptor superfamily (4)
- TNFR1 (4)
- Tandem-Massenspektrometrie (4)
- Tandem-Reaktion (4)
- Telekommunikationsnetz (4)
- Temperaturabhängigkeit (4)
- Textsorte (4)
- Th17 (4)
- Theoretische Ökologie (4)
- Theorie (4)
- Theory of Mind (4)
- Thymom (4)
- Tiere (4)
- Transfer (4)
- Transforming Growth Factor (4)
- Transgenic mice (4)
- Transkriptionsfaktoren (4)
- Translokation (4)
- Transpiration <Pflanzen> (4)
- Transplantatabstoßung (4)
- Triarylborane (4)
- Trypanosomiasis (4)
- Tubulin (4)
- Tumorerkrankungen (4)
- Typ 1 (4)
- USP28 (4)
- UV/Vis spectroscopy (4)
- Ultraschnelle Photochemie (4)
- Ultraviolett-Photoelektronenspektroskopie (4)
- Umweltrecht (4)
- Unabhängigkeit (4)
- Unlauterer Wettbewerb (4)
- Unternehmenstheorie (4)
- Ureaplasma parvum (4)
- Urheberrecht (4)
- Urin (4)
- Urämietoxine (4)
- VEP (4)
- Vaccinia Virus (4)
- Validität (4)
- Vektor <Genetik> (4)
- Velocity-Map-Imaging (4)
- Verfassungsrecht (4)
- Verhaltensstörung (4)
- Verkapselung (4)
- Verkehrssicherheit (4)
- Verlauf (4)
- Verletzung (4)
- Versorgungsqualität (4)
- Verzeichnis (4)
- Viren (4)
- Vitamin D3 (4)
- Vitamin-D-Mangel (4)
- Volkskunde (4)
- Vorhofflimmern (4)
- Vorläuferzelle (4)
- Völkerrecht (4)
- Wachstumsfaktoren (4)
- Wald (4)
- Wasser (4)
- Wasserhaushalt (4)
- Wasseroxidation (4)
- Wasserstoffperoxid (4)
- Wassertransport (4)
- Weimarer Republik (4)
- Wellenpaket (4)
- Wide-gap-Halbleiter (4)
- William (4)
- Williams, Raymond (4)
- Wirbelsäulenverletzung (4)
- Wirkmechanismus (4)
- Wirkstoff-Rezeptor-Bindung (4)
- Wirkstoffe (4)
- Wirkung (4)
- Wirt (4)
- Wirtschaft (4)
- Wirtschaftsinformatik (4)
- Wirtszelle (4)
- Wissenschaftssprache (4)
- Wissensrepräsentation (4)
- Wittig-Reaktion (4)
- Wnt (4)
- Wnt-Proteine (4)
- Wolfgang Amadeus (4)
- Wolframkomplexe (4)
- XML (4)
- Xmrk (4)
- Yoga (4)
- Z boson (4)
- Zahnimplantat (4)
- Zeitaufgelöste Spektroskopie (4)
- Zeitauflösung (4)
- Zeitreihe (4)
- Zellkontakt (4)
- Zement (4)
- Zinkoxid (4)
- Zufriedenheit (4)
- Zwangsstörung (4)
- Zweisprachigkeit (4)
- Zwitterion (4)
- abscisic acid (4)
- accumulation (4)
- action (4)
- active galactic nuclei (4)
- acute respiratory distress syndrome (4)
- adhesion molecules (4)
- adipocytes (4)
- adjuvant treatment (4)
- adrenal (4)
- adrenal insufficiency (4)
- adulte Neurogenese (4)
- adulthood (4)
- affect (4)
- age-related macular degeneration (4)
- agency (4)
- albumin (4)
- alkaline phosphatase (4)
- allogene Stammzelltransplantation (4)
- amyotrophic-lateral-sclerosis (4)
- analgesia (4)
- aneurysm (4)
- angeborenes Immunsystem (4)
- animals (4)
- anion channel (4)
- ankle (4)
- antagonist (4)
- antagonists (4)
- antibacterial (4)
- antibiotic (4)
- antifungals (4)
- antimicrobial (4)
- antioxidant (4)
- antiretroviral therapy (4)
- antisense RNA (4)
- apis mellifera (4)
- appendicitis (4)
- aquaporin (4)
- arteriosclerosis (4)
- arthroplasty (4)
- arthropods (4)
- athletes (4)
- atopic dermatitis (4)
- attention-deficit/hyperactivity disorder (ADHD) (4)
- attentional bias (4)
- autism (4)
- autoantigen (4)
- autoimmune (4)
- avatars (4)
- awareness (4)
- axonal damage (4)
- balance (4)
- beta diversity (4)
- bevacizumab (4)
- bilingualism (4)
- binding analysis (4)
- biochemistry (4)
- biodiversity conservation (4)
- biofilm formation (4)
- biofilms (4)
- biomass (4)
- blazar (4)
- blood plasma (4)
- body composition (4)
- bone adhesive (4)
- bone substitute (4)
- bone-mineral density (4)
- borylenes (4)
- brain edema (4)
- bridging (4)
- cAAC (4)
- calcium phosphate cement (4)
- cancer immunotherapy (4)
- cancer metabolism (4)
- cancer patients (4)
- candida albicans (4)
- capsaicin (4)
- carbanion (4)
- carbohydrates (4)
- carbon (4)
- carborane (4)
- cardiac magnetic resonance imaging (4)
- cardiac metabolism (4)
- cardiorespiratory fitness (4)
- cardiovascular genetics (4)
- care (4)
- cell-cycle arrest (4)
- characterization (4)
- chemotaxis (4)
- chiral separation (4)
- chlamydia trachomatis (4)
- chondrogenesis (4)
- chondrogenic differentiation (4)
- cluster analysis (4)
- cochlea (4)
- colon (4)
- colony-stimulating factor (4)
- combination therapy (4)
- comparative genomic hybridization (4)
- compensation (4)
- complement system (4)
- complication (4)
- computational chemistry (4)
- consciousness (4)
- consortium (4)
- context (4)
- convolutional neural network (4)
- cooperation (4)
- corporate assessment (4)
- corporate law (4)
- corpus linguistics (4)
- correlation (4)
- costs (4)
- critical care (4)
- crosstalk (4)
- crowdsensing (4)
- culture (4)
- cycloaddition (4)
- cysteine protease (4)
- deadwood enrichment (4)
- death receptors (4)
- decellularization (4)
- decoherence (4)
- deficiency (4)
- definition (4)
- dehydrocoupling (4)
- dermatology (4)
- desflurane (4)
- desmosome (4)
- desmosomes (4)
- diabetic nephropathy (4)
- diborane (4)
- diboranes (4)
- diboration (4)
- diffuse large B-cell lymphoma (4)
- dimerization (4)
- disease severity (4)
- drosophila (4)
- drug metabolism (4)
- drug repurposing (4)
- dyes/pigments (4)
- dynamic (4)
- dysgnathia (4)
- dyslexia (4)
- ecological intensification (4)
- economic growth (4)
- economics (4)
- ecosystem function (4)
- ecosystem service (4)
- editorial (4)
- electroencephalogram (4)
- electron (4)
- electron tomography (4)
- emotional regulation (4)
- emotionale Kompetenz (4)
- entanglement (4)
- epithelium (4)
- essential genes (4)
- estrogen receptor (4)
- excited states (4)
- exciton coupling (4)
- exciton dynamics (4)
- experimental stroke (4)
- exposure therapy (4)
- extracorporeal membrane oxygenation (4)
- extrazelluläre Matrix (4)
- face processing (4)
- failure (4)
- feminism (4)
- ferroptosis (4)
- fertility (4)
- fibrin (4)
- fibronectin (4)
- fish model (4)
- fitness (4)
- flagellum (4)
- flow (4)
- fluorescent protein (4)
- fluoroarene (4)
- follow up (4)
- foot (4)
- forensic neurotraumatology (4)
- fullerenes (4)
- functional analysis (4)
- functional characterization (4)
- functional diversity (4)
- functionalization (4)
- fungal structure (4)
- gait analysis (4)
- gait initiation (4)
- games (4)
- genetic loci (4)
- genome annotation (4)
- geoarchaeology (4)
- geography (4)
- gingivitis (4)
- globalization (4)
- glucose transporter (4)
- glutamine (4)
- gynecology (4)
- habitats (4)
- halothane (4)
- head (4)
- healthy volunteers (4)
- heart rate variability (4)
- hematology (4)
- hepatitis C virus (4)
- hernia (4)
- hip fracture (4)
- homologous recombination (4)
- host cells (4)
- humanized mice (4)
- hybrid materials (4)
- hydrodynamics (4)
- hydrogen bonding (4)
- hydrolysis (4)
- hydroxyapatite (4)
- hypercortisolism (4)
- hypofractionation (4)
- iNOS (4)
- iPSC (4)
- image processing (4)
- imaging techniques (4)
- immune checkpoint blockade (4)
- immunohistochemistry techniques (4)
- immunosenescence (4)
- individual-based model (4)
- induction (4)
- infant (4)
- influenza A virus (4)
- innate immune response (4)
- inpatient rehabilitation (4)
- insect brain (4)
- insulin receptor (4)
- intellectual disability (4)
- intensive care (4)
- interoception (4)
- intervention (4)
- interview (4)
- invasive aspergillosis (4)
- invasive pulmonary aspergillosis (4)
- ion channels (4)
- ionic liquids (4)
- jet energy resolution (4)
- kardiale Hypertrophie (4)
- kidney function (4)
- learning curve (4)
- left ventricular hypertrophy (4)
- lenalidomide (4)
- lines (4)
- linguistics (4)
- linkage (4)
- lipid bilayer (4)
- lipidomics (4)
- literature (4)
- living cells (4)
- locus coeruleus (4)
- lokale Selbstregelungen (4)
- loneliness (4)
- macular degeneration (4)
- magnesium phosphate cement (4)
- maize (4)
- malignant melanoma (4)
- mammalian cells (4)
- man-computer interface (4)
- mandible (4)
- manganese (4)
- marine sponge (4)
- mass (4)
- mathematics (4)
- matrix metalloproteinase (4)
- matrix metalloproteinases (4)
- measurement (4)
- medical research (4)
- medullary thyroid carcinoma (4)
- melatonin (4)
- melody (4)
- memory B cells (4)
- men (4)
- meningioma (4)
- meningococci (4)
- mesenchymal stromal cells (4)
- metabarcoding (4)
- metabolic adaptation (4)
- metabolic test (4)
- miRNAs (4)
- microRNAs (4)
- microarrays (4)
- microcavity (4)
- micronucleus test (4)
- middle cerebral artery occlusion (4)
- middle ear (4)
- migrants (4)
- mindfulness (4)
- minimally invasive surgery (4)
- mitochondrial DNA (4)
- modulation (4)
- molecular modeling (4)
- molecular modelling (4)
- molecular recognition (4)
- molybdenum (4)
- mood (4)
- morality (4)
- morphometry (4)
- mtDNA (4)
- multi-fluid mixture (4)
- multisensory integration (4)
- multisensory processing (4)
- musculoskeletal system (4)
- mutagenesis (4)
- mutagenicity (4)
- myasthenia gravis (4)
- myelination (4)
- myocardial perfusion (4)
- myofibroblast (4)
- n-Halbleiter (4)
- nNOS (4)
- natural enemies (4)
- natural language processing (4)
- nature conservation (4)
- networks (4)
- neural stem cell (4)
- neural stem cells (4)
- neurodevelopment (4)
- neuroimaging (4)
- neuroimmunology (4)
- neutrophil (4)
- new species (4)
- nociception (4)
- non-covalent interactions (4)
- noradrenaline (4)
- norepinephrine transporter (4)
- nuclear magnetic resonance (4)
- oligodendrocytes (4)
- oligomerization (4)
- oncogenes (4)
- opioid receptors (4)
- opioids (4)
- optical coherence tomography (4)
- organic (4)
- organic photovoltaics (4)
- organoid (4)
- orientation (4)
- osteoblast (4)
- osteotomy (4)
- outbreak (4)
- oxidative addition (4)
- oxygenation (4)
- p38 (4)
- paediatrics (4)
- palliative care (4)
- paraganglioma (4)
- parallel corpus (4)
- parasite (4)
- parasitology (4)
- parathyroid (4)
- particle physics (4)
- patient (4)
- patient blood management (4)
- pentacoordinate (4)
- peptides (4)
- performance monitoring (4)
- periodic catatonia (4)
- perioperative management (4)
- periprothetische Infektion (4)
- personality traits (4)
- pharmacogenetics (4)
- pharmacotherapy (4)
- phase transition (4)
- phenotypic plasticity (4)
- pheochromocytoma (4)
- pheromone (4)
- phosphate (4)
- phosphoantigen (4)
- phosphorescence (4)
- photodissociation (4)
- photodynamic therapy (4)
- photophysics (4)
- phytoprostanes (4)
- plant cuticle (4)
- plasmonics (4)
- platinum (4)
- pluripotency (4)
- political discourse (4)
- pollution (4)
- polycycles (4)
- polygenic risk score (4)
- polymer (4)
- polymerization (4)
- population genetics (4)
- positron-emission-tomography (4)
- post-traumatic stress disorder (4)
- postoperative Komplikationen (4)
- preclinical research (4)
- preterm (4)
- principal component analysis (4)
- prognostic factor (4)
- prognostic marker (4)
- prognostic value (4)
- propofol (4)
- protease inhibitor (4)
- protein domains (4)
- protein structure (4)
- protein synthesis (4)
- protein-protein interaction (4)
- proteome (4)
- psychische Belastung (4)
- psycho-oncology (4)
- psychophysics (4)
- pulmonary embolism (4)
- punishment (4)
- purification (4)
- quality control (4)
- quality indicators (4)
- quantum control (4)
- radar (4)
- radiation therapy (4)
- radiochemotherapy (4)
- radiology (4)
- radionuclide therapy (4)
- rainforest (4)
- reaction time (4)
- reactivity (4)
- reading (4)
- real-time (4)
- recommendations (4)
- red blood cells (4)
- regulator (4)
- regulator genes (4)
- regulatorische T Zellen (4)
- regulatory T-cells (4)
- religion (4)
- renal failure (4)
- reoperation (4)
- replacement (4)
- reporter gene (4)
- reproduction (4)
- resonant tunneling diode (4)
- response regulator (4)
- results (4)
- retrospektiv (4)
- reverse transcriptase (4)
- rheology (4)
- rhodopsin (4)
- ribosomal RNA (4)
- ribosome biogenesis (4)
- risk assessment (4)
- root (4)
- ruthenium complexes (4)
- saccades (4)
- salivary gland (4)
- saproxylic beetles (4)
- scaling (4)
- schistosomiasis (4)
- score (4)
- secondary metabolites (4)
- selenium (4)
- self-regulation (4)
- sequence analysis (4)
- sequence motif analysis (4)
- sex (4)
- sex determination (4)
- sexual selection (4)
- shRNA (4)
- shape (4)
- signalling pathways (4)
- singlet oxygen (4)
- small intestine (4)
- smartwatch (4)
- soccer (4)
- social media (4)
- social systems (4)
- specialization (4)
- speech (4)
- sperm (4)
- spermatogenesis (4)
- spermiogenesis (4)
- sphingomyelinase (4)
- spillover (4)
- spin injection (4)
- spleen (4)
- spoken language (4)
- standardization (4)
- startle reflex (4)
- statins (4)
- stemness (4)
- stent (4)
- stereogen (4)
- stereogenic (4)
- stereoselektive Synthese (4)
- stimulation (4)
- strain (4)
- strain rate (4)
- streptomyces (4)
- streptozotocin (4)
- stress response (4)
- stromal cells (4)
- strong coupling (4)
- structure-activity relationships (4)
- struvite (4)
- substantia nigra (4)
- sulfur (4)
- supramolekulare Chemie (4)
- surface water (4)
- surgical and invasive medical procedures (4)
- surgical oncology (4)
- surveillance (4)
- survival analysis (4)
- sustained fear (4)
- synapses (4)
- synaptonemal complex (4)
- synthetic biology (4)
- systemic sclerosis (4)
- systems (4)
- thermal conductivity (4)
- thiol-ene (4)
- thromboembolism (4)
- thrombolysis (4)
- thrombopoiesis (4)
- thymic carcinoma (4)
- thyroid (4)
- time series analysis (4)
- toe (4)
- toll-like receptors (4)
- tomato (4)
- top quark mass (4)
- topology (4)
- total knee replacement (4)
- toxicology (4)
- trabecular meshwork (4)
- transactivation (4)
- transcriptome analysis (4)
- transient absorption spectroscopy (4)
- transient ischemic attack (4)
- transition metal complex (4)
- transition metal complexes (4)
- transposable elements (4)
- triarylamine (4)
- triarylborane (4)
- troponin (4)
- trypanosoma (4)
- tryptophan (4)
- tumor heterogeneity (4)
- tumor suppressor gene (4)
- tungsten (4)
- two-dimensional materials (4)
- tyrosine kinase (4)
- ultimatum game (4)
- ultrafast photochemistry (4)
- ultrastructure (4)
- unconscious processing (4)
- urinary tract infection (4)
- urine (4)
- user experience (4)
- validity (4)
- valuation of a company (4)
- vasculogenesis (4)
- velocity (4)
- vesicles (4)
- viability (4)
- viral infection (4)
- virotherapy (4)
- viruses (4)
- visual attention (4)
- visual perception (4)
- vitamin C (4)
- wall shear stress (4)
- wax (4)
- x (4)
- xxx (4)
- youth (4)
- zinc (4)
- zinc oxide nanoparticles (4)
- Östrogenrezeptor (4)
- Übelkeit (4)
- Überexpression (4)
- 16S rRNA (3)
- 18F-DCFPyL (3)
- 18F-FDG PET/CT (3)
- 18F-LMI1195 (3)
- 3D models (3)
- 3D powder printing (3)
- 3D scaffolds (3)
- 3D-Stereophotogrammetrie (3)
- 3D-Zellkultur (3)
- 4-0xadiazin-6-ones (3)
- 5-HT1A (3)
- 5-HT2C (3)
- 5-HTT (3)
- 5-Methylcytosine (3)
- 5-fluorouracil (3)
- A-priori-Wissen (3)
- A1 (3)
- ABR (3)
- ACE (3)
- ADP (3)
- AKT (3)
- AML (3)
- ARIA (3)
- ASC (3)
- Abschirmung (3)
- Abschlussprüfer (3)
- Absolute Configuration (3)
- Acetylcholinesterase (3)
- Acetylcholinrezeptor (3)
- Acetylsalicylsäure (3)
- Acne inversa (3)
- Actinoide (3)
- Actinomycetes (3)
- AdS/CFT correspondence (3)
- Adaptation (3)
- Adaptive Optics (3)
- Adaptive Optik (3)
- Adaptivregelung (3)
- Adaptorproteine (3)
- Additive Fertigung (3)
- Adenom-Karzinom-Sequenz (3)
- Adhesion (3)
- Adhäsine (3)
- Adrenalin (3)
- Adrenerger Rezeptor (3)
- Advanced Analytics (3)
- Advanced Glycation Endproducts (3)
- Adventitia (3)
- Affenimmundefizienzvirus (3)
- Age (3)
- Agency (3)
- Aging (3)
- Aktiengesellschaft (3)
- Aktienrecht (3)
- Aktin-Zytoskelett (3)
- Aktionspotenzial (3)
- Aktivität (3)
- Akupunktur (3)
- Akute lymphatische Leukämie (3)
- AlGaAs (3)
- Albino rats (3)
- Albumin (3)
- Aldehyde (3)
- Aldosteronantagonist (3)
- Algorithmische Geometrie (3)
- Alkaloid (3)
- Alkaloide (3)
- Allgemeine Entzündungsreaktion (3)
- Allgemeine atmosphärische Zirkulation (3)
- Allogeneic stem cell transplantation (3)
- Alopecia areata (3)
- Alterssicherung (3)
- Altertum (3)
- Aluminium (3)
- Ambulante Behandlung (3)
- Ameisenstaat (3)
- Aminosäure (3)
- Amisulprid (3)
- Amphibian oocytes (3)
- Amphiphile Verbindungen (3)
- Amplitude (3)
- Amyloid <beta-> (3)
- Amyloidose (3)
- Anastomose (3)
- Anatomie (3)
- Andrea (Komponist) (3)
- Angewandte Mathematik (3)
- Angewandte Psychologie / Zeitschrift / Experimentelle Psychologie (3)
- Angiographie (3)
- Angiotensin (3)
- Angola (3)
- Anion (3)
- Anisotropie (3)
- Anthracenderivate (3)
- Anthropocene (3)
- Antiangiogenese (3)
- Antibiotikatherapie (3)
- Antibodies (3)
- Antiferromagnetismus (3)
- Antigen CD22 (3)
- Antimalariamittel (3)
- Antimikrobielle Peptide (3)
- Antimykotika (3)
- Antipsychotika (3)
- Antworthemmung (3)
- Antwortverhalten (3)
- Anästhetikum (3)
- Apherese (3)
- Aplysina aerophoba (3)
- Apobec (3)
- Araneae (3)
- Arbeit (3)
- Arbeitsplatz (3)
- Arctic (3)
- Arginin (3)
- Aromastoff (3)
- Aromatically annulated triquinacenes (3)
- Aromatisch anellierte Triquinacene (3)
- Array (3)
- Arrhythmie (3)
- Art (3)
- Arthroplasty (3)
- Artificial Intelligence (3)
- Aseptische Lockerung (3)
- Association study (3)
- Assyriologie (3)
- Asteraceae (3)
- Atemwege (3)
- Atorvastatin (3)
- Atta vollenweideri (3)
- Attika (3)
- Attraktivität (3)
- Audit Quality (3)
- Aufklärungsgespräch (3)
- Aufmerksamkeitsprozesse (3)
- Augendruck (3)
- Ausgrabung (3)
- Auslauftrichter (3)
- Ausländer (3)
- Ausstellung (3)
- Auswertung (3)
- Authentizität (3)
- Autismus (3)
- Autoantibodies (3)
- Automatische Klassifikation (3)
- Automatisiertes Fahren (3)
- Autonomes Fahrzeug (3)
- Autonomous UAV (3)
- Autoradiography (3)
- Außenhandel (3)
- Avatar <Informatik> (3)
- B-cell (3)
- BIS (3)
- BL-Lacertae-Objekt (3)
- BN compounds (3)
- BP180 (3)
- BRAF mutation (3)
- Bacillus anthracis (3)
- Baden (3)
- Bakteriophagen (3)
- Bandwürmer (3)
- Bariatrische Chirurgie (3)
- Basalganglien (3)
- Basilarmembran (3)
- Basketball (3)
- Batterie (3)
- Bauchwandhernie (3)
- Bayesian classifier (3)
- Bcl-2-Proteinfamilie (3)
- Bedeutung (3)
- Bedürfnis (3)
- Befestigungskomposit (3)
- Behaviour (3)
- Benchmarking (3)
- Benn, Gottfried (3)
- Berechnungskomplexität (3)
- Bernasconi (3)
- Beruf (3)
- Beryllium (3)
- Beschleunigungssensor (3)
- Bestärkendes Lernen <Künstliche Intelligenz> (3)
- Bewegung (3)
- Bewegungssehen (3)
- Bewegungsstörung (3)
- Bewertung (3)
- Bewältigung (3)
- Bias (3)
- Biene <Gattung> (3)
- Bienenwolf (3)
- Big Data (3)
- Bild (3)
- Bilderbuch (3)
- Bildqualität (3)
- Bildrekonstruktion (3)
- Bindegewebe (3)
- Biodistribution (3)
- Biofabrikation (3)
- Biographieforschung (3)
- Biokinetics (3)
- Biologische Aktivität (3)
- Biologisches Material (3)
- Biomarkers (3)
- Biomedical engineering (3)
- Bioprinting (3)
- Biosensor (3)
- Biosphärenreservat (3)
- Biotechnologie (3)
- Bipolare Störung (3)
- Biradicals (3)
- Biradikale (3)
- Blickbewegung (3)
- Blochmannia (3)
- Blockchain (3)
- Bluthochdruck (3)
- Blutspiegel (3)
- Blutverlust (3)
- Bone marrow transplantation (3)
- Bone morphogenetic protein-2 (3)
- Bordetella bronchiseptica (3)
- Borirene (3)
- Borkomplexe (3)
- Borreliose (3)
- Borylentransfer (3)
- Bosons (3)
- Brachytherapie (3)
- Brackets (3)
- Brain-computer interface (3)
- Bridging (3)
- Brombeere (3)
- Brownsche Bewegung (3)
- Bruchfläche (3)
- Buchdruck (3)
- Bundeswehr (3)
- Bupivacain (3)
- Burkholderia (3)
- Business Intelligence (3)
- Butyrate (3)
- C/EBP (3)
- C5aR1 (3)
- CA3 (3)
- CAAC (3)
- CAD/CAM (3)
- CAR T cell (3)
- CAR T cells (3)
- CCL2 (3)
- CCR2 (3)
- CCR7 (3)
- CD22 (3)
- CD23 (3)
- CD27 (3)
- CD39 (3)
- CD4(+) (3)
- CD4+ T cells (3)
- CD40L (3)
- CD73 (3)
- CD8 T cell (3)
- CD9 (3)
- CDH13 (3)
- CEA (3)
- CGH (3)
- CMT (3)
- CNO (3)
- CO2 (3)
- COVID-19 pandemic (3)
- COVID‐19 (3)
- CRMO (3)
- CTGF (3)
- CVD (3)
- CYP11B2 (3)
- Calcium Imaging (3)
- Calcium-bindende Proteine (3)
- Calciumhydroxid (3)
- Calciumphosphatzemente (3)
- Calciumtransport (3)
- Calibration (3)
- Camerloher (3)
- Cannabinoide (3)
- Capsaicin (3)
- Carbenoide (3)
- Carcino-embryonales Antigen (3)
- Carcinogenicity (3)
- Carcinogens (3)
- Cardiomyopathy (3)
- Carrier-Proteine (3)
- Cas9 (3)
- CaseTrain (3)
- Caspase (3)
- Caspr (3)
- CdSe (3)
- CdTe (3)
- CePt5 (3)
- Cell cycle (3)
- Cells (3)
- Central nervous system (3)
- Ceramid (3)
- Cerebellar cortex (3)
- Cerebrospinal fluid (3)
- Chaos (3)
- Chaostheorie (3)
- Chaperone (3)
- Charcot-Marie-Syndrom (3)
- Chemieunterricht (3)
- Chemische Kommunikation (3)
- Chemokin CXCL10 (3)
- Chemokinrezeptor (3)
- Chimärismus (3)
- Chirality (3)
- Chirp (3)
- Cholesterinstoffwechsel (3)
- Cholinesteraseinhibitor (3)
- Chondrozyten (3)
- Chromosomes (3)
- Chronisch-myeloische Leukämie (3)
- Circadian Rhythms (3)
- Circular Dichroism (3)
- Circular dichroism (3)
- Classification (3)
- Cluster (3)
- Cochlea-Implantat (3)
- Coexpression (3)
- Coffein (3)
- Coherent control (3)
- Coleoptera (3)
- Collagen (3)
- Comorbidity (3)
- Complexity (3)
- Computer Vision (3)
- Computerspiel (3)
- Conference (3)
- Coping (3)
- Copula (3)
- Corpus amygdaloideum (3)
- Coulomb-Blockade (3)
- Cranio-Corpo-Graphie (3)
- Creation (3)
- Crohn's disease (3)
- Cu(111) (3)
- Cyanobacteria (3)
- Cycloadditionen (3)
- Cycloadditions (3)
- Cystic fibrosis (3)
- Cytogenetik (3)
- Cytostatikum (3)
- DAT (3)
- DBH (3)
- DFB laser (3)
- DMD (3)
- DNA damage response (3)
- DNA double strand breaks (3)
- DNA double-strand breaks (3)
- DNS-Schaden (3)
- DNS-Sequenz (3)
- DSG2 (3)
- DTI (3)
- DW-MRI (3)
- DWI (3)
- DYT1 (3)
- DaTscan (3)
- Data Fusion (3)
- Data Warehouse (3)
- Dauerfrostboden (3)
- Deeskalation (3)
- Definition (3)
- Deformation (3)
- Demethylierung (3)
- Deoxyribozymes (3)
- Dermatologie (3)
- Desmogleine (3)
- Detektion (3)
- Devisenmarkt (3)
- Diabetes Mellitus (3)
- Diboran(4) (3)
- Diborin (3)
- Dictyostelium (3)
- Dienstleistung (3)
- Differentialgeometrie (3)
- Diffusionsgewichtete Magnetresonanztomographie (3)
- Digital Religions (3)
- Diindenoperylen (3)
- Dilatation (3)
- Dimorphismus (3)
- Dionaea muscipula (3)
- Discounter (3)
- Dispersion (3)
- Dissertation (3)
- Distributed Control (3)
- Diversität (3)
- Docking (3)
- Doppler-Echokardiographie (3)
- Dosimetrie (3)
- Dosis-Wirkungs-Beziehung (3)
- Down syndrome (3)
- Drahtloses lokales Netz (3)
- Dreiecksgitter (3)
- Druckmessung (3)
- Drug resistance (3)
- Duchenne muscular dystrophy (3)
- Duchenne-Syndrom (3)
- Durchflußzytometrie (3)
- Durchstrahlungselektronenmikroskopie (3)
- Dynamisches System (3)
- Düne (3)
- Dünndarmtransplantation (3)
- Dünnschichttransistor (3)
- E-cadherin (3)
- E. coli Nissle 1917 (3)
- ECMO (3)
- EDA (3)
- ELBWI (3)
- EMT (3)
- EPC (3)
- EPR spectroscopy (3)
- ESS (3)
- Echtzeitsystem (3)
- Ecosystem services (3)
- Effektivität (3)
- Efficiency (3)
- Egypt (3)
- Ehescheidung (3)
- Eiablage (3)
- Eigenwert (3)
- Einfluss (3)
- Einflussfaktoren (3)
- Einkommensverteilung (3)
- Einsilbiges Wort (3)
- Einstellung (3)
- Einzelhandelsbetrieb (3)
- Einzelhandelsentwicklung (3)
- Einzelmolekülspektroskopie (3)
- Eisenmangel (3)
- Elastizität (3)
- Elastizitätsmodul (3)
- Electroencephalographie (3)
- Electron Microscopy (3)
- Electropermeabilization (3)
- Electrophysiology (3)
- Elektrochromie (3)
- Elektrofusion (3)
- Elektron-Phonon-Wechselwirkung (3)
- Elektronenspinresonanzspektroskopie (3)
- Elektronensprayionisations-Massenspektrometrie (3)
- Elektronische Eigenschaft (3)
- Elektrorheologie (3)
- Ellenbogen (3)
- Eltern (3)
- Embodiment (3)
- Emerin (3)
- Emotionsverarbeitung (3)
- Empfängnisverhütung (3)
- Empowerment (3)
- Encephalomyelitis (3)
- Endobrachyösophagus (3)
- Endokrinologie (3)
- Endotheliale Dysfunktion (3)
- Energieeffizienz (3)
- Energy Efficiency (3)
- Energy Transfer (3)
- Enoyl-acyl-carrier-protein-Reductase <Enoyl-[acyl-carrier-protein]-Reductase> (3)
- Entgeltumwandlung (3)
- Entmarkung (3)
- Entnahmemorbidität (3)
- Entscheidungsfindung (3)
- Environment (3)
- Enzephalitis (3)
- Enzyme (3)
- Enzyme induction (3)
- Enzyme-linked immunosorbent assay (3)
- Enzymes (3)
- Enzymkinetik (3)
- Epac (3)
- Ephedrin (3)
- Epichloë (3)
- Epidermaler Wachstumsfaktor (3)
- Epidermis (3)
- Ereignisdatenanalyse (3)
- Ergospirometrie (3)
- Erneuerbare Energien (3)
- Erratum (3)
- Erregbarkeit (3)
- Erreger (3)
- Erste Hilfe (3)
- Ertaubung (3)
- Erwachsene (3)
- Erweiterte Realität <Informatik> (3)
- Erythrozyt (3)
- Erzähltechnik (3)
- Erzählung (3)
- Essstörungen (3)
- Estrogene (3)
- Etomidat (3)
- European beech (3)
- Europäische Ethnologie (3)
- Event (3)
- Event-related potential (3)
- Events (3)
- Evoziertes Potenzial (3)
- Exciton (3)
- Expansion microscopy (3)
- Experimentelle autoimmune Enzephalomyelitis (3)
- Extrazellulärraum (3)
- Exzitonenkopplung (3)
- FAEP (3)
- FAP (3)
- FIR-Spektroskopie (3)
- FKBP5 (3)
- FMRI (3)
- FRAP (3)
- FSME (3)
- FT-IR-Spektroskopie (3)
- FTY720 (3)
- FabI (3)
- Fabry-associated pain (3)
- Fahrerassistenz (3)
- Faktorenanalyse (3)
- Fallstudie (3)
- Fanconi Anaemia (3)
- Fear (3)
- Femtochemie (3)
- Femtosekunden (3)
- Femtosekundenlaser (3)
- Fernröntgenseitenbild (3)
- Ferrocen (3)
- Ferromagnetic Semiconductors (3)
- Ferromagnetische Schicht (3)
- Fettsäurebiosynthese (3)
- Fettsäuren (3)
- Fibrin (3)
- Fibromyalgia syndrome (3)
- Fibronektin (3)
- Finite Elemente (3)
- Fisch (3)
- Fische (3)
- Flavour <Elementarteilchen> (3)
- Flavourmischung (3)
- Fließfähigkeit (3)
- Flora (3)
- Fluid (3)
- Fluor-19 (3)
- Fluorescence spectroscopy (3)
- Fluoxetin (3)
- Fluss (3)
- Foldamers (3)
- Follow-up (3)
- Forecasting (3)
- Formulierung (3)
- Formulierungsentwicklung (3)
- Fossile Muscheln (3)
- Fotochemie (3)
- FoxP3 (3)
- Fragmentbefestigung (3)
- Frailty (3)
- Franconia (3)
- Frauenarbeit (3)
- Freiburger Sprachverständnistest (3)
- Freie-Elektronen-Laser (3)
- Fremdsprache (3)
- Frequenzvervielfachung (3)
- Fries (3)
- Frosch (3)
- Frühgeborenes (3)
- Frühgeburt (3)
- Frühneuhochdeutsch (3)
- Fulleren (3)
- Fundusautofluoreszenz (3)
- Fusarium (3)
- Fusion (3)
- G-Protein (3)
- G-Proteine (3)
- G-protein-coupled receptors (3)
- GAS2L3 (3)
- GDF-15 (3)
- GDF-5 (3)
- GFP (3)
- GLUT3 (3)
- GM-CSF (3)
- Galectine (3)
- Galerkin-Methode (3)
- Gamma-Burst (3)
- Ganztagsschule (3)
- Gasgemisch (3)
- Gasphase (3)
- Gastric-banding (3)
- Gastrointestinaler Tumor (3)
- Gauge-gravity correspondence (3)
- Gaussian approximation (3)
- Gebrechlichkeit (3)
- Gebärmutterhalskrebs (3)
- Gefahr (3)
- Gefäßpflanzen (3)
- Gelernte Hilflosigkeit (3)
- Gemcitabin (3)
- Gen-Knockout (3)
- Gender Studies (3)
- Gene therapy (3)
- Genome (3)
- Genomics (3)
- Genotyp (3)
- Gentamicin (3)
- Geoarchäologie (3)
- Geografie (3)
- Geomorphogenese (3)
- Geomorphology (3)
- Gerechtigkeit (3)
- Gerinnungsfaktor XII (3)
- German (3)
- Germanen (3)
- Geschichte 1800-1900 (3)
- Geschlechtschromosomen (3)
- Geschmack (3)
- Gesellschaften ohne Zentralgewalt (3)
- Gestationsdiabetes (3)
- Gesundheitssystem (3)
- Gesundheitsverhalten (3)
- Gewebekleber (3)
- Gewebemodell (3)
- Gibbs free energy of binding (3)
- Gingivitis (3)
- Gitterbaufehler (3)
- Glaskeramik (3)
- Gletscher (3)
- Glia (3)
- Glioblastoma multiforme (3)
- Glucocorticoide (3)
- Glucosetransport (3)
- Glucosinolate (3)
- Glukose (3)
- Glutamat (3)
- Glutamat-Decarboxylase (3)
- Glutathione (3)
- Glycin (3)
- Golgi (3)
- Grad-seq (3)
- Grading (3)
- Graft-versus-host disease (3)
- Gram-positive bacteria (3)
- Griechenland (3)
- Griechisch (3)
- Grimmelshausen (3)
- Grippe (3)
- Grundfrequenz (3)
- Grundwasser (3)
- Grundwasserbildung (3)
- Guillain-Barré syndrome (3)
- HFOV (3)
- HFpEF (3)
- HFrEF (3)
- HSM (3)
- Hadron Colliders (3)
- Halogene (3)
- Hamburg (3)
- Hand (3)
- Handschrift (3)
- Haplotypanalyse (3)
- Harmonic Imaging (3)
- Harnableitung (3)
- Harninkontinenz (3)
- Harnwegsinfektionen (3)
- Hauptgruppenelementverbindungen (3)
- Hautflügler (3)
- Hautmodell (3)
- Hearing loss (3)
- Hefeartige Pilze (3)
- Helicasen (3)
- Heliosphäre (3)
- Hepatotoxizität (3)
- Herbivory (3)
- Hereditäres Angioödem (3)
- Hermeneutik (3)
- Herrschaft (3)
- Herz-Lungen-Maschine (3)
- Herzoperation (3)
- Herzrhythmusstörung (3)
- Herzstoffwechsel (3)
- Herztransplantation (3)
- Heteroepitaxie (3)
- Heterostruktur-Bauelement (3)
- Hexacoordination (3)
- Hexakoordination (3)
- Hey (3)
- Hill numbers (3)
- Hip (3)
- Hirnendothelzellen (3)
- Hirnforschung (3)
- Hirnhautentzündung (3)
- Hirninfarkt (3)
- Hirnmetastasen (3)
- Hirnstimulation (3)
- Hirschsprung disease (3)
- Histon-Deacetylase (3)
- Historische Aufnahme (3)
- Hitzeschockprotein (3)
- Hitzeschockproteine (3)
- Hitzeschocktranskriptionsfaktor (3)
- Hitzestress (3)
- Hochdosischemotherapie (3)
- Hochschullehrende (3)
- Hochschulschrift (3)
- Hodgkin lymphoma (3)
- Hofkomponist (3)
- Holozän (3)
- Homerus (3)
- Human-Computer Interaction (3)
- Humans (3)
- Hummel (3)
- Hummeln (3)
- Hydroborierung (3)
- Hydroxyethylstärke (3)
- Hyperalgesie (3)
- Hyperekplexie (3)
- Hyperglykämie (3)
- Hypernephrom (3)
- Hyperthermie (3)
- Hämodiafiltration (3)
- Höranstrengung (3)
- Hörprüfung (3)
- Hüftprothese (3)
- Hüfttotalendoprothese (3)
- ICU (3)
- IGF-1 (3)
- IGF-I (3)
- IGRT (3)
- IL-12 (3)
- IS256 (3)
- ISS (3)
- IT-Sicherheit (3)
- IVF (3)
- Identität (3)
- Identitätsentwicklung (3)
- Ideomotorik (3)
- IgE (3)
- IgG (3)
- IgM (3)
- Iminoborane (3)
- Immundefekt (3)
- Immunglobulin (3)
- Immunglobulin M (3)
- Immunohistochemistry (3)
- Immunoseneszenz (3)
- Immunosuppression (3)
- Impedanzspektroskopie (3)
- Implantate (3)
- Implantation (3)
- In-vitro (3)
- Index (3)
- Indiumarsenid (3)
- Indiumphosphid (3)
- Individuationsprozess (3)
- Industrie 4.0 (3)
- Infarkt (3)
- Inflation Targeting (3)
- Information (3)
- Information Extraction (3)
- Information Retrieval (3)
- Inhaltsanalyse (3)
- Inhibitorische Synapse (3)
- Initiation (3)
- Inklusion <Soziologie> (3)
- Inklusiver Unterricht (3)
- Innere Uhr (3)
- Insects (3)
- Insulinresistenz (3)
- Intensivmedizin (3)
- Intensivtransport (3)
- Interleukin (3)
- Interleukin 17 (3)
- Interleukin 5 (3)
- Interleukin-1 (3)
- Interleukin-5 (3)
- Interleukin-6 (3)
- Intermedialität (3)
- Internationale Politik (3)
- Internationales Gesellschaftsrecht (3)
- Intervention (3)
- Interventionsradiologie (3)
- Intraokularer Druck (3)
- Intrazellulärraum (3)
- Inzidentalom (3)
- Inzidenz (3)
- Inzidenz <Medizin> (3)
- Iod (3)
- Ionische Flüssigkeiten (3)
- Irradiation (3)
- Ischemia (3)
- Ischemic stroke (3)
- Ischämischer Schlaganfall (3)
- Isolierung (3)
- Isomer (3)
- Italien (3)
- Italienisch (3)
- J- and H-Aggregate (3)
- J- and H-Aggregates (3)
- Jurassic (3)
- Kafka (3)
- Kaiserschnitt (3)
- Kalzium (3)
- Kaninchen (3)
- Kannenpflanze (3)
- Kanzerogenese (3)
- Kardiomyozyt (3)
- Kardiomyozyten (3)
- Kardioprotektion (3)
- Kardiovaskuläre Krankheit (3)
- Karyotyp (3)
- Karzinom (3)
- Karzinomzellen (3)
- Katarakt (3)
- Katatonie (3)
- Katecholamine (3)
- Kausalmodell (3)
- Kehlkopf (3)
- Kenyon cells (3)
- Keramikfaser (3)
- Kernspinrelaxation (3)
- Ketogene Kost (3)
- Ketonkörper (3)
- Ki-67 (3)
- Ki67 (3)
- Kiefer- und Gesichtschirurgie (3)
- Kiefernrindenextrakt (3)
- Kinderchirurgie (3)
- Kleinkinderziehung (3)
- Klimamodell (3)
- Klimaschutz (3)
- Klinische Psychotherapie (3)
- Klinische Studie (3)
- Klonalität (3)
- Knee (3)
- Kniegelenkarthrose (3)
- Knochenmarktransplantation (3)
- Knochennekrose (3)
- Knochenstoffwechsel (3)
- Knochentumor (3)
- Knockdown (3)
- Knockout-Maus (3)
- Knorpelintegration (3)
- Koffein (3)
- Kognitive Psychologie (3)
- Kognitive Verhaltenstherapie (3)
- Kognitiver Prozess (3)
- Kohlendioxid (3)
- Kokultur (3)
- Kolon (3)
- Kolonialismus (3)
- Komfortlaut (3)
- Kommune (3)
- Kommunikationstraining (3)
- Komplexes regionales Schmerzsyndrom (3)
- Kompressionstherapie (3)
- Komprimierte Abtastung (3)
- Kondo-Modell (3)
- Kondo-System (3)
- Konfidenzintervall (3)
- Konjugate (3)
- Konjugation (3)
- Kontamination (3)
- Kontinenz (3)
- Kontrolle (3)
- Kontrolltheorie (3)
- Konvergenz (3)
- Konversationsanalyse (3)
- Kopforthesentherapie (3)
- Korbblütler (3)
- Koronarchirurgie (3)
- Koronarperfusion (3)
- Korpuslinguistik (3)
- Korrektur (3)
- Korrelative Mikroskopie (3)
- Kosmische Strahlung (3)
- Kraftmessung (3)
- Kraniopharyngeom (3)
- Kraniopharyngiom (3)
- Krankenhaus (3)
- Krankheitsverlauf (3)
- Kreatinkinase (3)
- Kreditmarkt (3)
- Krieg (3)
- Kulturkontakt (3)
- Kulturtheorie (3)
- Kunst (3)
- Kurfürst (3)
- Kurzzeitphysik (3)
- Körper (3)
- Körperwahrnehmung (3)
- L929 (3)
- LAD (3)
- LC-HRESIMS (3)
- LIF (3)
- LNCaP (3)
- LTD (3)
- Lactatdehydrogenase (3)
- Laminopathie (3)
- Landschaft (3)
- Landschaftsentwicklung (3)
- Landshuter Gesangbuch (3)
- Langzeitdepression (3)
- Langzeitprognose (3)
- Larve (3)
- Laryngeale Konstriktion (3)
- Larynx (3)
- Larynxkarzinom (3)
- Laserchemie (3)
- Laserdiode (3)
- Laserstrahlung (3)
- Late Enhancement (3)
- Learning and memory (3)
- Lebendgebärende Zahnkarpfen (3)
- Lebensdauer (3)
- Lebensmitteleinzelhandel (3)
- Lebermetastase (3)
- Legasthenie (3)
- Legionellen (3)
- Lehr-Lern-Labor (3)
- Lehramtsstudium (3)
- Lehrerhandreichung (3)
- Lehrkräftebildung (3)
- Leistenhernie (3)
- Lenalidomid (3)
- Lepra (3)
- Lepton (3)
- Lernstrategien (3)
- Lerntechnik (3)
- Letalität (3)
- Leukoplakie (3)
- Lewis acid (3)
- Lewis-Addukt (3)
- Lexikographie (3)
- LiDAR (3)
- Licht (3)
- Lichtstreuung (3)
- Lidschlag (3)
- Ligamentum cruciatum anterius (3)
- Linear Pottery (3)
- Linienbreite (3)
- Lipidmembran (3)
- Lipidstoffwechsel (3)
- Lipopolysaccharid (3)
- Lipopolysaccharide (3)
- Lipoxygenase (3)
- Lipoxygenase <5-> (3)
- Literaturunterricht (3)
- Ljapunov-Funktion (3)
- LoRaWAN (3)
- Lolium perenne (3)
- Luminescence (3)
- Lungenentzündung (3)
- Lungenmetastase (3)
- Lungenperfusionsmodell (3)
- Lungentumor (3)
- Lurche (3)
- Luttinger-Flüssigkeit (3)
- Lycopersicon esculentum (3)
- Lyme-Krankheit (3)
- Lymphocytes (3)
- Lymphoma (3)
- Lysosomale Speicherkrankheit (3)
- Lysozym (3)
- Ländlicher Raum (3)
- Längsschnittstudie (3)
- MALT-Lymphom (3)
- MALT1 (3)
- MAP kinase (3)
- MC simulation (3)
- MDD (3)
- MDR (3)
- MDSC (3)
- MEK (3)
- MGMT (3)
- MHC Klasse II (3)
- MLC1 (3)
- MMN (3)
- MMP-9 (3)
- MOF (3)
- MOFs (3)
- MPI (3)
- MSCT (3)
- MSSM (3)
- Magma (3)
- Magnesiumphosphat (3)
- Magnetic Anisotropy (3)
- Magnetische Eigenschaft (3)
- Magnetoelastizität (3)
- Magnetohydrodynamik (3)
- Magnetresonanz (3)
- Magnetresonanztomografie (3)
- Makrocyclische Verbindungen (3)
- Malariamücke (3)
- Malaysia (3)
- Malignant Hyperthermia (3)
- Malignant hyperthermia (3)
- Malignant melanoma (3)
- Malnutrition (3)
- Mamma (3)
- Manganate (3)
- Manganselenide (3)
- Mangansilicide (3)
- Mannheim (3)
- Mantelzell-Lymphom (3)
- Mantle cell lymphoma (3)
- Mapping (3)
- Marker (3)
- Markteintrittsstrategie (3)
- Materielle Kultur (3)
- Matrixmetalloproteinasen (3)
- Maximilian <Bayern> (3)
- Mc4r (3)
- Measurement (3)
- Measuring Masses (3)
- Mechanorezeptor (3)
- Mechanotransduktion (3)
- Medien-/Kulturwissenschaft (3)
- Medienanalyse (3)
- Medienkonsum (3)
- Medizinische Ausbildung (3)
- Medizinische Rehabilitation (3)
- Medizinstudium (3)
- Megakaryocyte (3)
- Megakaryopoese (3)
- Mehrschichtsystem (3)
- Melatonin (3)
- Melt Electrowriting (3)
- Melt electrowriting (3)
- Memantin (3)
- Membranpotential (3)
- Membranrezeptor (3)
- Memristor (3)
- Meningococci (3)
- Meniskus (3)
- Merkel cell polyomavirus (3)
- Merkel-Zellkarzinom (3)
- Merocyanin (3)
- Mesenchymal Stem Cells (3)
- Mesenchymale Stromazellen (3)
- Mesophyll (3)
- Mesoskopisches System (3)
- Metall-Isolator-Phasenumwandlung (3)
- Metallcarbonyle (3)
- Metallkomplexe (3)
- Metalloarenophane (3)
- Metalloberfläche (3)
- Metalloprotease (3)
- Metallorganische Chemie (3)
- Metapher (3)
- Metastasierung (3)
- Methodenentwicklung (3)
- Methohexital (3)
- Methotrexate (3)
- Methyltransferase (3)
- Metoprolol (3)
- Microdialyse (3)
- Migrationshintergrund (3)
- Mikrokavität (3)
- Mikroklima (3)
- Mikrooptik (3)
- Mikroporosität (3)
- Mikrosatelliten (3)
- Mikrotubuli (3)
- Mikroverkapselung (3)
- Mineralisation (3)
- Mineralokortikoidrezeptor (3)
- Mip (3)
- Mismatch (3)
- Mittelhochdeutsch (3)
- Mittelmeerraum (3)
- Modifizierung (3)
- Molecular Beam Epitaxy (3)
- Molecular biology (3)
- Molecular dynamics (3)
- Monoaminoxidase (3)
- Monodromie (3)
- Monte Carlo simulation (3)
- Morphogenese (3)
- Mosaik (3)
- Motorische Entwicklung (3)
- Mott-Übergang (3)
- Mouse model (3)
- Mucorales (3)
- Multiagentensystem (3)
- Multimedia (3)
- Multiple bonds (3)
- Multispecies Studies (3)
- Mundart (3)
- Mundhöhle (3)
- Mundhöhlenkrebs (3)
- Mundhöhlentumor (3)
- Muscarin (3)
- Muscarinic receptor subtypes (3)
- Muscarinic receptors (3)
- Museumspädagogik (3)
- Musikwahrnehmung (3)
- Muskelkraft (3)
- Muster (3)
- Mutante (3)
- Mutationsrate (3)
- Mycobacterium (3)
- Myelin oligodendrocyte glycoprotein antibodies (MOG-IgG) (3)
- Myeloma (3)
- Mythos (3)
- Mädchenfußball (3)
- Münchner Hof (3)
- N-Heterocyclic Carbenes (3)
- N-heterocyclic carbene (3)
- N170 (3)
- NADPH-Oxidase (3)
- NIR (3)
- NK cell (3)
- NK-Zellen (3)
- NLS (3)
- NMR-spectroscopy (3)
- NOS1AP (3)
- NSG (3)
- NSSI (3)
- NT-proBNP (3)
- NVP-BEZ235 (3)
- Nabelhernie (3)
- Nachruf (3)
- Nahtmaterial (3)
- Nanoelektronik (3)
- Naphthalinderivate (3)
- Naphthylisochinoline (3)
- Narrative (3)
- Narratologie (3)
- Natalizumab (3)
- Nationalpark (3)
- Natrium (3)
- Natrium-Calcium-Austauscher (3)
- NaturenKulturen (3)
- Nebennierenkrise (3)
- Nepenthes (3)
- Nervenstimulation (3)
- Nervensystem (3)
- Nestin (3)
- Networks (3)
- Netzwerkmanagement (3)
- Neumarkt <Oberpfalz> (3)
- Neuroblast (3)
- Neuromyelitis optica spectrum disorders (NMOSD) (3)
- Neuronale Netze (3)
- Neuropeptid Y (3)
- Neuroprotection (3)
- Neuropsychologie (3)
- Neuroscience (3)
- Neurotizismus (3)
- Neurotransmitter (3)
- Neurotrophe Faktoren (3)
- Neurotrophine (3)
- Neutrophil (3)
- Neutrophils (3)
- New Zealand (3)
- Nichtadiabatischer Prozess (3)
- Nichtionisierende Strahlung (3)
- Nichtkonvexe Optimierung (3)
- Nichtlineares System (3)
- Nicotin (3)
- Nicotine (3)
- Nicotinischer Acetylcholinrezeptor (3)
- Niederdimensionales Elektronengas (3)
- Niederdimensionales System (3)
- Nierenkrebs (3)
- Nitric oxide (3)
- Nociceptor (3)
- Noradrenalin (3)
- Norm (3)
- Nozizeption (3)
- Nozizeptor (3)
- Nrf2 (3)
- Nucleolus (3)
- Nude-mice (3)
- ODMR-Spektroskopie (3)
- OSAS (3)
- OST1 (3)
- Oberflächenplasmonresonanz (3)
- Octopamin (3)
- Octopamine (3)
- Olfaktion (3)
- Olfaktorik (3)
- Oligonucleotide (3)
- Omega-3-Fettsäuren (3)
- Omp85 (3)
- Oncostatin M (3)
- Oogenese (3)
- Open Access (3)
- Operante Konditionierung (3)
- Optic neuritis (3)
- Optical Spectroscopy (3)
- Optische Eigenschaft (3)
- Optische Zeichenerkennung (3)
- Organic Semiconductors (3)
- Organisationskultur (3)
- Organische Halbleiter (3)
- Orient (3)
- Orientalistik (3)
- Oropharynx (3)
- Osmolarität (3)
- Osseointegration (3)
- Osteoarthrose (3)
- Osteoblast (3)
- Osteoklast (3)
- Osteoporosis (3)
- Outcome survey (3)
- OxLDL (3)
- Oxygen (3)
- P-glycoprotein (3)
- PDGF (3)
- PDZ-Domain (3)
- PDZ-Domäne (3)
- PFC (3)
- PKA (3)
- PKB (3)
- PLC (3)
- PMCA (3)
- PNP (3)
- PROM (3)
- PTSD (3)
- PZT (3)
- Paclitaxel (3)
- Pair Production (3)
- Pakistan (3)
- Palliative Care (3)
- Palliativversorgung (3)
- Pappel (3)
- Paracyclophane (3)
- Paraffin (3)
- Parallel Imaging (3)
- Pareto-Verteilung (3)
- Parkinson Disease (3)
- Parkinsons disease (3)
- Particle Physics (3)
- Particle data analysis (3)
- Passionsspiel (3)
- Passivrauchen (3)
- Patella (3)
- Pathogener Mikroorganismus (3)
- Pathogenitätsinseln (3)
- Pathology (3)
- Pathophysiologie (3)
- Patientenschulung (3)
- Patterns (3)
- Peer-to-Peer-Netz (3)
- Pentacoordination (3)
- Peristaltik (3)
- Peritonitis (3)
- Permafrost (3)
- Peroxisom (3)
- Persönlichkeitsmerkmale (3)
- Persönlichkeitsstörung (3)
- Perylen (3)
- Pest (3)
- Phagosom (3)
- Pharmaceutical Analysis (3)
- Pharmazeutischer Hilfsstoff (3)
- Phonologie (3)
- Phosphate (3)
- Phosphorylation (3)
- Photoinduzierter Elektronentransfer (3)
- Photoluminescence (3)
- Photolyse (3)
- Photolysis (3)
- Photonische Kristalle (3)
- Photonischer Kristall (3)
- Photopolymerisation (3)
- Photosensibilisator (3)
- Physical activity (3)
- Physik jenseits des Standardmodells (3)
- Physikunterricht (3)
- Physiologische Psychologie (3)
- Phytohormone (3)
- Piperidinalkaloide (3)
- Plaque (3)
- Plasmodium (3)
- Plastik (3)
- Plattform (3)
- Platy (3)
- Pleuraerguss (3)
- Plexus brachialis (3)
- Pluripotenz (3)
- Plättchen (3)
- Pneumolysin (3)
- Poetik (3)
- Poetologie (3)
- Polycomb (3)
- Polycyclic Aromatic Hydrocarbons (3)
- Polyglycidol (3)
- Polymerase chain reaction (3)
- Polymers (3)
- Polymorphismen (3)
- Polyomaviren (3)
- Populationsgenetik (3)
- Poribacteria (3)
- Porphyrin (3)
- Porphyrine (3)
- Poröser Stoff (3)
- Positron Emission Tomography (3)
- Positron emission tomography (3)
- Postmoderne (3)
- Posttranslationale Änderung (3)
- Predictors (3)
- Pregnancy (3)
- Preisbindung (3)
- Prionprotein (3)
- Procyanidine (3)
- Professionalisierung (3)
- Prognosefaktor (3)
- Prognosefaktoren (3)
- Promoter (3)
- Prophylaxe (3)
- Prostate Cancer (3)
- Prostatektomie (3)
- Protection (3)
- Protein p8 (3)
- Protein-Serin-Threonin-Kinasen (3)
- Proteinkinase CK2 (3)
- Proteinkinase D (3)
- Proteintransport (3)
- Proteinurie (3)
- Proteomics (3)
- Proton-Proton Collisions (3)
- Protonenpumpe (3)
- Protozoen (3)
- Präfrontaler Kortex (3)
- Prüfungshonorare (3)
- Pseudarthrose (3)
- Pseudomonas aeruginosa (3)
- Psychology (3)
- Psychoneuroimmunologie (3)
- Psychopathologie (3)
- Psychophysik (3)
- Psychotherapeutischer Prozess (3)
- Psychotherapy (3)
- Pulswelle (3)
- Purkinje cells (3)
- Pycnogenol (3)
- Pyrrolizidinalkaloide (3)
- QCD (3)
- QST (3)
- Quadrotor (3)
- Quantenelektrodynamik (3)
- Quantitative Analyse (3)
- Quantum Monte Carlo (3)
- Quantum dots (3)
- Quantum dynamics (3)
- Quantum information (3)
- Quantum many-body systems (3)
- Quartär (3)
- Quercetin (3)
- RIM101 (3)
- RKIP (3)
- RNA structure (3)
- RNA-SEQ (3)
- RNA-sequencing (3)
- RNAseq (3)
- RNS-Viren (3)
- RPE (3)
- RSK2 (3)
- RT-qPCR (3)
- Rac (3)
- Radarsat-2 (3)
- Radiation (3)
- Radikal (3)
- Radiochemotherapie (3)
- Radiologie (3)
- Radiosurgery (3)
- Radius (3)
- Raman Spektroskopie (3)
- Ranunculus auricomus (3)
- Rassismus (3)
- Rastertunnelspektroskopie (3)
- Rating (3)
- Rats (3)
- Raucher (3)
- Raumverhalten (3)
- Rauschen (3)
- Real-time PCR (3)
- Reanimation (3)
- Rechnungswesen (3)
- Rechtschreibschwäche (3)
- Recovery (3)
- Recurrence (3)
- Recurrensparese (3)
- Reduction (3)
- Reform (3)
- Reformpädagogik (3)
- Regionalanästhesie (3)
- Regionalwirtschaft (3)
- Regularisierung (3)
- Rekombinantes Protein (3)
- Relapse (3)
- Relaxometry (3)
- Reliabilität (3)
- Religious Education (3)
- Religiöse Bildung (3)
- Remifentanil (3)
- Remineralisation (3)
- Remission (3)
- Renaissance (3)
- Renal cell carcinoma (3)
- Renin-Angiotensin-Aldosteron-System (3)
- Replikationsursprung (3)
- Repression <Genetik> (3)
- Reproduktion (3)
- Resistance (3)
- Resonanz-Raman-Effekt (3)
- Resonanz-Tunneldiode (3)
- Resonanz-Tunneleffekt (3)
- Ressourcenallokation (3)
- Restaurative Zahnmedizin (3)
- Restenose (3)
- Retinoic acid (3)
- Retinsäure (3)
- Rezeptortyrosinkinase (3)
- Rezidivrate (3)
- Rheumatologie (3)
- Rho (3)
- Rho GTPase (3)
- Rhodiumkomplexe (3)
- Riester-Rente (3)
- Ringspannung (3)
- Risikomanagement (3)
- Risk Assessment (3)
- Risk factors (3)
- Ritual (3)
- Rossameise (3)
- Rubus (3)
- Ruthenium Komplexe (3)
- Räumliche Verteilung (3)
- Römisches Reich (3)
- Röntgenabsorptionsspektroskopie (3)
- Röntgenastronomie (3)
- Röntgenkristallographie (3)
- Röntgenmikroskopie (3)
- Röntgenstrukturanalyse (3)
- SBRT (3)
- SEM (3)
- SF-36 (3)
- SGLT (3)
- SIRS (3)
- SIV (3)
- SLAM (3)
- SLOOP (3)
- SM background (3)
- SMARD1 (3)
- SOCE (3)
- SPECT/CT (3)
- SRT (3)
- STAT (3)
- STIM2 (3)
- STM (3)
- STR (3)
- Salmonella typhi (3)
- Salz (3)
- Samenpflanzen (3)
- Sammeln (3)
- Sarkopenie (3)
- Satellitenfernerkundung (3)
- Satzglied (3)
- Scarabaeidae (3)
- Scattering (3)
- Scheibe-Aggregat (3)
- Scherstress (3)
- Schichttechnik (3)
- Schilddrüsenkarzinom (3)
- Schleimhaut (3)
- Schleswig-Holstein (3)
- Schließzellen (3)
- Schockraumalgorithmus (3)
- Schreckreaktion (3)
- Schreimelodie (3)
- Schwann cells (3)
- Schwingungsspektroskopie (3)
- Search (3)
- Secretion (3)
- Sectio caesarea (3)
- Sedimentologie (3)
- Segmentierung (3)
- Sekundarstufe 1 (3)
- Selbstgesteuertes Lernen (3)
- Selbstmord (3)
- Selenoprotein P (3)
- Self-Assembly (3)
- Semantik (3)
- Semiconductors (3)
- Seneca (3)
- Senescence (3)
- Seneszenz (3)
- Sensors (3)
- Sequenzierung (3)
- Serotonin-Reuptake-Hemmer (3)
- Serotoninstoffwechsel (3)
- Serotonintransporter (3)
- Service Learning (3)
- Sexualität (3)
- Shigella (3)
- Shigella flexneri (3)
- Sicherheit (3)
- Sicherheitspolitik (3)
- Siedlungsarchäologie (3)
- Signaltransduction (3)
- Silanderivate (3)
- Siloran (3)
- Simulationstraining (3)
- Singlet Oxygen (3)
- Singulettsauerstoff (3)
- Sinnesphysiologie (3)
- Situationsbewusstsein (3)
- Skalierbarkeit (3)
- Skiverletzung (3)
- Skorpion (3)
- Social Cognition (3)
- Social interaction (3)
- Socrates (3)
- Software-defined networking (3)
- Softwarearchitektur (3)
- Solubilisation (3)
- Sonnenwind (3)
- Sozialangst (3)
- Sozialgeschichte (3)
- Sozialisation (3)
- Sozialität (3)
- Soziologie des Dritten (3)
- Species richness (3)
- Speckle tracking (3)
- Speiseröhre (3)
- Spektroelektrochemie (3)
- Spermatogenesis (3)
- Spezialisierung (3)
- Spieltheorie (3)
- Spin-Gitter-Relaxation (3)
- Spinal Muscular Atrophy (3)
- Spinalanästhesie (3)
- Spinalganglion (3)
- Spinnenseide (3)
- Spironolacton (3)
- Spleißen (3)
- Spleißosom (3)
- Splicing (3)
- Sprachverständlichkeit (3)
- Spred Protein (3)
- Src-Proteine (3)
- Staat (3)
- Stachellose Biene (3)
- Staging (3)
- Stakeholder (3)
- Standardisierung (3)
- Staphylokokken (3)
- Stat3 (3)
- Sterbebegleitung (3)
- Stereophotogrammetrie (3)
- Stereophotogrammetry (3)
- Stereoselectivity (3)
- Sternpolymere (3)
- Steroide (3)
- Steroidhormon (3)
- Steuer (3)
- Stickstoffoxide (3)
- Stochastische Resonanz (3)
- Stochastischer Prozess (3)
- Stomata (3)
- Stoßwelle (3)
- Strafrecht (3)
- Straftat (3)
- Strafvollzug (3)
- Strahlung (3)
- Strainrate (3)
- Strandkiefer (3)
- Structural elucidation (3)
- Strukturbasiertes Wirkstoffdesign (3)
- Strömung (3)
- Suberin (3)
- Substantia nigra (3)
- Substratspezifität (3)
- Succinylcholine (3)
- Sucht (3)
- Suizidalität (3)
- Sulforaphan (3)
- Super-resolution microscopy (3)
- Superparamagnetismus (3)
- Supersymmetric models (3)
- Supply Chain (3)
- Surface plasmons (3)
- Switzerland (3)
- Symmetry (3)
- Synaptische Transmission (3)
- Synaptische Vesikel (3)
- Synchronisierung (3)
- Synchronization (3)
- Systemisches Risiko (3)
- Süddeutsche Zeitung (3)
- Südkorea (3)
- Südostasien (3)
- T cell development (3)
- T cell receptors (3)
- T lymphocyte (3)
- T-Zell-Rezeptor (3)
- T-Zellaktivierung (3)
- T-Zellrezeptor (3)
- T-cell lymphoma (3)
- TCR (3)
- TD-DFT (3)
- TEM (3)
- TGF-ß (3)
- TGN1412 (3)
- THA (3)
- TLR3 (3)
- TLR8 (3)
- TNF superfamily (3)
- TRAF1 (3)
- TRH (3)
- TRPA1 (3)
- TTFields (3)
- Taiwan (3)
- Talentförderung (3)
- Tantal (3)
- Targeted therapy (3)
- Taxol (3)
- Teaching (3)
- Testament (3)
- Testbatterie (3)
- Testosteron (3)
- Text (3)
- Textvergleich (3)
- Therapieergebnisse (3)
- Therapieresistenz (3)
- Thermoelektrizität (3)
- Thiazolidindione (3)
- Thigmotaxis (3)
- Thioaldehyde (3)
- Thiophen (3)
- Thioredoxin (3)
- Thrombozytenaktivierung (3)
- Thrombozytopenie (3)
- Thrombus (3)
- Thyroid cancer (3)
- Tibiakopfbruch (3)
- Tibiakopfimpressionsfraktur (3)
- Tiergesellschaft (3)
- Tierversuch (3)
- Tierökologie (3)
- Titanium (3)
- Tolerance (3)
- Tomografie (3)
- Topoisomerase I (3)
- Topological insulators (3)
- Topologische Phase (3)
- Topology (3)
- Tourette syndrome (3)
- Tourism (3)
- Trachea (3)
- Tragik (3)
- Transaktivierung (3)
- Transforming Growth Factor beta 1 (3)
- Transiente Absorptionsspektroskopie (3)
- Transistor (3)
- Translation <Genetik> (3)
- Transparent-leitendes Oxid (3)
- Transportspektroskopie (3)
- Tricalciumphosphat (3)
- Triphyophyllum peltatum (3)
- Triquinacenderivate (3)
- Trockenstress (3)
- Trypanosoma brucei brucei (3)
- Trypanosomes (3)
- Tuberculosis (3)
- Tuff (3)
- Tumor-necrosis-factor (3)
- Tumormodell (3)
- Tumorstammzellen (3)
- Tumorstoffwechsel (3)
- Tumorsuppressor-Gen (3)
- Tumortherapiefelder (3)
- Tumorwachstum (3)
- Tumorzellen (3)
- Turbulenz (3)
- Tyrosinkinaseinhibitor (3)
- UPEC (3)
- USP8 (3)
- Ubiquitin-Protein-Ligase (3)
- Ulcerative colitis (3)
- Ultrafiltration (3)
- Ultraschallkontrastmittel (3)
- Umbilikalhernie (3)
- Umweltfaktor (3)
- Umweltpolitik (3)
- Unterrichtsmethode (3)
- Ureaplasma urealyticum (3)
- Urothelkarzinom (3)
- Uzbekistan (3)
- VKORC1 (3)
- VLBWI (3)
- VMAT (3)
- VMD2 (3)
- VSOP (3)
- Variants (3)
- Varianzanalyse (3)
- Variationsrechnung (3)
- Vasopressin (3)
- Verbraucherschutz (3)
- Verbreitung (3)
- Vereinte Nationen (3)
- Vernetzung <Chemie> (3)
- Verstärkung (3)
- Verteilung (3)
- Vertigo (3)
- Vertrauen (3)
- Verwaltung (3)
- Verwundbarkeit (3)
- Vesikel (3)
- Viabilität (3)
- Vibrio cholerae (3)
- Video Streaming (3)
- Videolaryngoskopie (3)
- Videoübertragung (3)
- Vielfalt (3)
- Vietnam (3)
- Vif (3)
- Vigilanz (3)
- Virulenzfaktoren (3)
- Visuelles System (3)
- Visus (3)
- Viszeralchirurgie (3)
- Vitamin K (3)
- Volatile Anästhetika (3)
- Volumenregulation (3)
- Volumentomographie (3)
- Vorhofohramputation (3)
- Vorkommen (3)
- Vorlesung (3)
- Vorsprachliche Entwicklung (3)
- Vulgata (3)
- Vulkanologie (3)
- Vulneranz (3)
- W boson (3)
- WNT (3)
- Wachs (3)
- Warburg effect (3)
- Warnung (3)
- Wasserlöslichkeit (3)
- Weak (3)
- Wechselkurspolitik (3)
- Weiterbildung (3)
- Wellenleiter (3)
- Werbung (3)
- Wert (3)
- Wertigkeit (3)
- Wertschöpfungskette (3)
- Wespen (3)
- Western Cape (3)
- Weyarn / Stift (3)
- Wiederbelebung (3)
- Wilms Tumor (3)
- Wilms' tumor (3)
- Wirkstoff-Träger-System (3)
- Wirkstoffdesign (3)
- Wirtschaftsentwicklung (3)
- Wirtschaftsprüfer (3)
- Wirtschaftsprüfung (3)
- Wissenschaft (3)
- Wissenschaftlicher Nachwuchs (3)
- Wissenserwerb (3)
- Wissensmanagement (3)
- Working memory (3)
- Wurzelhalsgalle (3)
- Wurzelkanalbehandlung (3)
- Währungsunion (3)
- Wärmeübertragung (3)
- Würzburg / Institut für Humangenetik (3)
- Würzburg / Sonderforschungsbereich II-VI-Halbleiter (3)
- Würzburg / Universität / Lehrstuhl für Bioinformatik (3)
- Xenobiotikum (3)
- Xenophon (3)
- Xenopus oocytes (3)
- Xenotransplantation (3)
- Xylem (3)
- Y chromosome (3)
- YAP (3)
- YB-1 (3)
- Zahnersatz (3)
- Zahnprothetik (3)
- Zelloberfläche (3)
- Zentralasien (3)
- Zerfall (3)
- Zetafunktion (3)
- Zinn (3)
- Zivilgesellschaft (3)
- Zugspannung (3)
- Zweidimensionales Material (3)
- Zweiphotonenabsorption (3)
- Zwischenmolekulare Kraft (3)
- ab initio calculations (3)
- abiotic stress (3)
- abnormalities (3)
- absolute configuration (3)
- accelerometer (3)
- acceptance (3)
- acetylcholine (3)
- acetylsalicylic acid (3)
- acquisition (3)
- acrophobia (3)
- actins (3)
- action effects (3)
- activity (3)
- acupuncture (3)
- acute lymphoblastic leukemia (3)
- acute myeloid leukaemia (3)
- acute renal failure (3)
- adaption (3)
- adaptive immune system (3)
- adaptive immunity (3)
- addiction (3)
- adduct (3)
- adenocarcinoma of the lung (3)
- adenoma (3)
- adiponectin (3)
- adipose (3)
- adjuvant (3)
- adrenal gland (3)
- adrenocortical cancer (3)
- adult ADHD (3)
- adverse events (3)
- aerobic fitness (3)
- affinity (3)
- african trypanosomes (3)
- age groups (3)
- agonist (3)
- agr (3)
- agroecology (3)
- airway management (3)
- akutes Koronarsyndrom (3)
- aldehydes (3)
- allogeneic hematopoietic stem cell transplantation (3)
- alpha (3)
- alpha-synuclein (3)
- altitudinal gradients (3)
- alveolar echinococcosis (3)
- ambulant (3)
- anaemia (3)
- analysis (3)
- anandamide (3)
- anastomotic leakage (3)
- angiotensin II (3)
- animal sociality (3)
- anisotropy (3)
- annulation (3)
- ansa-Komplexe (3)
- anterior insula (3)
- antibakteriell (3)
- anticoagulants (3)
- antigen presentation (3)
- antigen testing (3)
- antimikrobielle Peptide (3)
- aortic aneurysm (3)
- aortic stenosis (3)
- applied physics (3)
- approach (3)
- approximation algorithm (3)
- arabidopsis (3)
- architecture (3)
- arctic (3)
- arrhythmogenic cardiomyopathy (3)
- artemisinin (3)
- articulation (3)
- artificial photosynthesis (3)
- aspirin (3)
- assay (3)
- assistierte Reproduktion (3)
- assistive technology (3)
- association study (3)
- associative learning (3)
- asymmetry (3)
- attention deficit/hyperactivity disorder (3)
- auditory cortex (3)
- auditory evoked potentials (3)
- auditory pathway (3)
- autism spectrum disorder (3)
- autograft (3)
- autologous stem cell transplantation (3)
- auxin (3)
- avidity (3)
- axonal transport (3)
- axons (3)
- azobenzenes (3)
- bZIP (3)
- bacillus subtilis (3)
- bacterial (3)
- bacterial infection (3)
- bacterial meningitis (3)
- bacteriophage (3)
- bark beetles (3)
- barrier (3)
- bee decline (3)
- beta-D-glucan (3)
- beta-oxidation (3)
- binding protein (3)
- bioactivity (3)
- bioconjugation (3)
- biogenic amines (3)
- bioinformatic (3)
- biological activity (3)
- biological models (3)
- biological pest control (3)
- biologics (3)
- bioluminescence imaging (3)
- biomedical engineering (3)
- biomedical materials (3)
- biosensor (3)
- biosensors (3)
- biotransformation (3)
- birds (3)
- birth cohort (3)
- bisphosphonates (3)
- black holes (3)
- bleeding (3)
- blended learning (3)
- blood coagulation (3)
- blood vessel (3)
- body ownership (3)
- bonding agent (3)
- bone defect (3)
- bone density (3)
- bone disease (3)
- bone metabolism (3)
- bone metastases (3)
- bone morphogenetic protein (3)
- bone morphogenetic proteins (3)
- bone-marrow (3)
- boroles (3)
- boronate (3)
- brain cancer (3)
- brain derived neurotrophic factor (3)
- breast-tumors (3)
- bruxism (3)
- bullous pemphigoid (3)
- bumblebees (3)
- burn severity (3)
- c-Fos (3)
- c-Myc (3)
- c-myc (3)
- cFLIP (3)
- calcification (3)
- calcium signaling (3)
- calorimetry (3)
- calpain (3)
- cancer cells (3)
- candida (3)
- canine (3)
- canine cancer therapy (3)
- canola (3)
- capecitabine (3)
- carabid beetles (3)
- carbene ligands (3)
- carbon nanotubes (3)
- carcinogenesis (3)
- carcinogenicity (3)
- carcinoma cells (3)
- cardiac MRI (3)
- cardiac imaging (3)
- cardiac rehabilitation (3)
- cardiolipin (3)
- cardiology (3)
- cardiovascular magnetic resonance (3)
- caspase-3 (3)
- caspases (3)
- cathepsin (3)
- cationic species (3)
- cations (3)
- causality (3)
- cell binding (3)
- cell fusion (3)
- cell imaging (3)
- cell labeling (3)
- cell therapy (3)
- central-nervous-system (3)
- ceramics (3)
- cerebEND (3)
- cerebellar tDCS (3)
- cerebrovascular disorders (3)
- cervical dystonia (3)
- cestode (3)
- chalcogens (3)
- channel (3)
- channelrhodopsin (3)
- chaperone (3)
- charge separation (3)
- charged aerosol detector (3)
- chemische Kommunikation (3)
- chimeric antigen receptor (3)
- chlamydia infection (3)
- cholesterol (3)
- chromophore (3)
- chronic stress (3)
- chronophin (3)
- cirrhosis (3)
- citrus (3)
- claudin-1 (3)
- clinical outcome (3)
- clinical practice (3)
- clonality (3)
- closed head injury (3)
- cluster (3)
- coating (3)
- coatings (3)
- cochlear implantation (3)
- coexistence (3)
- colonoscopy (3)
- community (3)
- community ecology (3)
- compliance (3)
- composite (3)
- conditioned response (3)
- confocal microscopy (3)
- conjugation (3)
- consolidation (3)
- contrast (3)
- conversion (3)
- convolutional neural networks (3)
- coordination polymer (3)
- coordination polymers (3)
- copy number variation (3)
- coreceptor (3)
- cornea (3)
- corneal confocal microscopy (3)
- coronary artery bypass grafting (3)
- correction (3)
- corticosteroids (3)
- count time series (3)
- criteria (3)
- critically ill (3)
- crossing minimization (3)
- crowdsourcing (3)
- cryptochrome (3)
- crystallography (3)
- curriculum (3)
- curved hydrocarbons (3)
- cycloid psychosis (3)
- cyclophanes (3)
- cytogenetics (3)
- cytosol (3)
- data acquisition (3)
- data analysis (3)
- data fusion (3)
- data mining (3)
- deafness (3)
- death (3)
- decomposition (3)
- defects (3)
- deficient mice (3)
- deformation (3)
- deformation quantization (3)
- deletion (3)
- density (3)
- dental implants (3)
- deoxyribozymes (3)
- depressive disorder (3)
- derivation (3)
- derivatives (3)
- desmin (3)
- detection (3)
- detrended fluctuation analysis (3)
- developmental differentiation (3)
- diagnostic (3)
- diagnostic markers (3)
- diagnostic medicine (3)
- diazepam (3)
- differential diagnosis (3)
- differentiation potential (3)
- diffusion tensor imaging (3)
- dilated cardiomyopathy (3)
- disease progression (3)
- diseases (3)
- disorder (3)
- distraction (3)
- diversity gradients (3)
- dizziness (3)
- doctoral graduates (3)
- dogs (3)
- double-blind (3)
- driving (3)
- drought stress (3)
- drug adverse reaction (3)
- drug allergy (3)
- drug development (3)
- drug hypersensitivity (3)
- drug release (3)
- drug resistance (3)
- drug therapy (3)
- duchenne muscular dystrophy (3)
- dunce (3)
- dynamic programming (3)
- dyspnea (3)
- early detection (3)
- early diagnosis (3)
- early intervention (3)
- eating behavior (3)
- edge states (3)
- electrical and electronic engineering (3)
- electrical impedance tomography (3)
- electrocardiography (3)
- electrochromic device (3)
- electrohydrodynamic (3)
- electrohydrodynamics (3)
- electron transfer (3)
- electroporation (3)
- elevated plus-maze (3)
- elevation (3)
- elevational gradient (3)
- elongation (3)
- embryonic stem cell (3)
- embryonic stem cells (3)
- embryos (3)
- emerin (3)
- emotion processing (3)
- emotion recognition (3)
- emotional processing (3)
- emphysema (3)
- empowerment (3)
- encapsulation (3)
- endophenotype (3)
- endophyte (3)
- endothelial barrier (3)
- endothelial cell (3)
- endotheliale Vorläuferzellen (3)
- endurance exercise (3)
- endurance training (3)
- engineering (3)
- entomology (3)
- entrepreneurship (3)
- entropy (3)
- entropy production (3)
- environmental health (3)
- environmental justice (3)
- epidermis (3)
- ereigniskorrelierte Potentiale (3)
- esophagus (3)
- essential tremor (3)
- ethics (3)
- etiology (3)
- etomidate (3)
- evidence-based medicine (3)
- evoked potentials (3)
- evozierte Potentiale (3)
- ex vivo (3)
- executive functions (3)
- exome sequencing (3)
- exosomes (3)
- expression analysis (3)
- extreme value theory (3)
- fMRT (3)
- fabry disease (3)
- face (3)
- face perception (3)
- fanconi anemia (3)
- fatty acid (3)
- fatty liver disease (3)
- fear of progression (3)
- feasibility (3)
- feeding (3)
- female (3)
- fermentation (3)
- ferroelectricity (3)
- ferromagnetism (3)
- fiber (3)
- fibroblast activation protein (3)
- finite element method (3)
- fire (3)
- fixation (3)
- flexibility (3)
- flow regulation (3)
- flow regulator (3)
- flowability (3)
- flowers (3)
- fluorescence correlation spectroscopy (3)
- fluorescence spectroscopy (3)
- fluoroquinolones (3)
- flux (3)
- foamy viruses (3)
- foamyvirus (3)
- food safety (3)
- force (3)
- forest ecology (3)
- formicidae (3)
- fpVCT (3)
- fragment reattachment (3)
- fragmentation (3)
- framing (3)
- free electron laser (3)
- frontotemporal dementia (3)
- fully convolutional neural networks (3)
- functional imaging (3)
- functional neuroimaging (3)
- functional training (3)
- fungal infections (3)
- fungal pathogens (3)
- fungal rhodopsins (3)
- furan (3)
- gametocyte (3)
- gamma astronomy (3)
- gamma radiation (3)
- gamma rays (3)
- gas (3)
- gastric bypass (3)
- gastroenterology (3)
- gastrointestinale Tumore (3)
- gefitinib (3)
- gekrümmte Kohlenwasserstoffe (3)
- gene expression profiling (3)
- generalization (3)
- genetic modifiers (3)
- genetic testing (3)
- genetic variation (3)
- genome assembly (3)
- genome integrity (3)
- genome sequence (3)
- genotyping (3)
- geometry (3)
- geophysics (3)
- gestaltungsorientierte Bildungsforschung (3)
- girls (3)
- glaciers (3)
- glial fibrillary acidic protein (3)
- global convergence (3)
- glomerular filtration rate (3)
- glomeruli (3)
- glutamate transporters (3)
- glutathione (3)
- glycoproteins (3)
- gold (3)
- grading (3)
- graft (3)
- grammar (3)
- granzyme B (3)
- graphene (3)
- growth cone (3)
- growth factor (3)
- growth hormone deficiency (3)
- guanylyl cyclase (3)
- guided bone regeneration (3)
- guinea pig (3)
- gynogenesis (3)
- haemodialysis (3)
- haemostasis (3)
- handlungs- und entwicklungsorientierte Didaktik (3)
- hands (3)
- hangover (3)
- hardness (3)
- head and neck (3)
- healing (3)
- healthcare (3)
- hearing aid (3)
- hearing screening (3)
- heart transplantation (3)
- heat shock protein (3)
- heat shock response (3)
- helicase (3)
- helminths (3)
- hematopoiesis (3)
- hemodiafiltration (3)
- hemoglobin (3)
- hemolysin (3)
- hepatitis B virus (3)
- hepatocellular carcinoma (3)
- hepatotoxicity (3)
- herbivores (3)
- herbivory (3)
- herpesvirus (3)
- heterogeneity (3)
- hiPSC-CM (3)
- high-intensity interval training (3)
- hip arthroplasty (3)
- histone H2AX (3)
- histones (3)
- histopathology (3)
- historical document analysis (3)
- history of medicine (3)
- homology modeling (3)
- honeycomb lattice (3)
- hormones (3)
- hospital (3)
- host-pathogen interactions (3)
- human brain (3)
- human brain microvascular endothelial cells (3)
- human genetics (3)
- human immunodeficiency virus (3)
- human learning (3)
- human rights (3)
- humane mesenchymale Stammzellen (3)
- humidity (3)
- hydrological modelling (3)
- hydrology (3)
- hyperalgesia (3)
- hypercholesterolemia (3)
- hypertrophic cardiomyopathy (3)
- idiopathic pulmonary fibrosis (3)
- illness (3)
- image quality (3)
- image segmentation (3)
- immediate early genes (3)
- immersive technologies (3)
- immune activation (3)
- immune escape (3)
- immune reconstitution (3)
- immune suppression (3)
- immunisation (3)
- immunoassay (3)
- immunoglobulin (3)
- immunoreactive neurons (3)
- impedance spectroscopy (3)
- impurities (3)
- impurity profiling (3)
- inclusion (3)
- indication for surgery (3)
- individual differences (3)
- individual-based simulation (3)
- infant cry (3)
- infants (3)
- infectious disease (3)
- inflammatory diseases (3)
- inflammatory response (3)
- information extraction (3)
- informed consent (3)
- infrared (3)
- innate immune system (3)
- instrument (3)
- insulator (3)
- intelligence (3)
- intensity distribution (3)
- intentional binding (3)
- interaction networks (3)
- interactome (3)
- interface (3)
- interleukin 4 (3)
- interleukin-4 (3)
- interleukin-6 (3)
- interleukins (3)
- intermanual transfer (3)
- intestinal barrier (3)
- intuition (3)
- invasive fungal infection (3)
- inventory (3)
- investigators (3)
- involvement (3)
- iodine (3)
- iron deficiency (3)
- irrigation (3)
- ischemia reperfusion injury (3)
- ischemia/reperfusion injury (3)
- islet transplantation (3)
- islets of Langerhans (3)
- isoliert (3)
- isomerization (3)
- isotopes (3)
- jet energy scale uncertainty (3)
- jets (3)
- juvenile hormone (3)
- ketogenic diet (3)
- kinase inhibitor (3)
- kinesin (3)
- kinetic model (3)
- knee joint (3)
- knee replacement (3)
- knock-out (3)
- kutikuläre Kohlenwasserstoffe (3)
- lamina (3)
- laminopathy (3)
- land-use change (3)
- landscape ecology (3)
- language development (3)
- laparoscopic ventral hernia repair (3)
- larynx (3)
- laser (3)
- leaf beetle (3)
- learning strategies (3)
- leaves (3)
- left ventricular ejection fraction (3)
- leishmania major (3)
- length of stenosis (3)
- leptin (3)
- leukemic cells (3)
- leukocytes (3)
- library screening (3)
- life events (3)
- life history (3)
- ligand (3)
- ligand binding (3)
- light quark jet (3)
- linkage analysis (3)
- lipid metabolism (3)
- liquid crystals (3)
- liraglutide (3)
- literature review (3)
- lithium-ion battery (3)
- liver metastasis (3)
- local field potentials (3)
- locomotor activity (3)
- low back pain (3)
- low-grade glioma (3)
- low-valent compounds (3)
- lower extremity (3)
- lung and intrathoracic tumors (3)
- lung injury (3)
- lymph node dissection (3)
- mCRP (3)
- mRNA expression (3)
- mTOR (3)
- macrocycle (3)
- macrocycles (3)
- magnesium phosphate (3)
- magnetic properties and materials (3)
- magnetic susceptibility (3)
- main group elements (3)
- major depressive disorder (3)
- major histocompatibility complex (3)
- malignancy (3)
- malignant tumors (3)
- malnutrition (3)
- mammography (3)
- marine natural products (3)
- masculinity (3)
- mastocytosis (3)
- maturation (3)
- mechanics (3)
- mechanosensing (3)
- media literacy (3)
- medical (3)
- medical students (3)
- megakaryopoiesis (3)
- melanogaster (3)
- melanoma cells (3)
- melt electrowriting (MEW) (3)
- memory formation (3)
- mercury (3)
- merocyanines (3)
- mesencephalic locomotor region (3)
- mesoscopic (3)
- mesoscopics (3)
- messenger-RNA (3)
- metabolic modeling (3)
- metabolischer Test (3)
- metabolites (3)
- metabonomics (3)
- metacognition (3)
- metacomprehension (3)
- metallocenophanes (3)
- metallosupramolecular chemistry (3)
- methionine restriction (3)
- methods (3)
- miR (3)
- miR-26 (3)
- micelles (3)
- microRNA-221 (3)
- microbial ecology (3)
- microbial rhodopsins (3)
- microclimate (3)
- microsatellites (3)
- microvascular endothelial cells (3)
- midazolam (3)
- mild cognitive impairment (3)
- mimicry (3)
- mineralocorticoid receptor (3)
- minimal-invasiv (3)
- mitotane (3)
- mixed methods (3)
- mobile health (3)
- modular (3)
- molecular characterization (3)
- molecular cloning (3)
- molecular diagnostics (3)
- molecular epidemiology (3)
- molecular phylogeny (3)
- molecular structure (3)
- monoamine oxidase (3)
- morphogenesis (3)
- mosaicism (3)
- mothers (3)
- multi-unit recording (3)
- multijet background (3)
- multilocularis (3)
- multiple bonds (3)
- multiple linear regression (3)
- multiple system atrophy (3)
- muscarinic antagonists (3)
- muscarinic receptor subtypes (3)
- muscle strength (3)
- mutants (3)
- mutation analysis (3)
- mycotoxins (3)
- myeloma (3)
- myopathy (3)
- nanoparticle (3)
- nanotechnology (3)
- nanotube (3)
- naphthalene diimide (3)
- national park (3)
- national parks (3)
- natural history (3)
- natural killer cells (3)
- natural variation (3)
- necroptosis (3)
- necrosis-factor-alpha (3)
- negative affect (3)
- neoadjuvant (3)
- neonate (3)
- nerve fibers (3)
- nest climate (3)
- network analysis (3)
- networking (3)
- neural crest (3)
- neurofilament light chain (3)
- neurological disorders (3)
- neuromodulation (3)
- neuromonitoring (3)
- neuronal (3)
- neuronal network (3)
- neuronal nitric oxide synthase (3)
- neuropathischer Schmerz (3)
- neuropathology (3)
- neuropsychology (3)
- neurotrophic factors (3)
- new media (3)
- newborn (3)
- next-generation sequencing (3)
- niche (3)
- nicht-kovalente Wechselwirkungen (3)
- nicotine addiction (3)
- non-prompt lepton (3)
- non-verbal communication (3)
- nonsmooth optimization (3)
- nuclear export (3)
- nuclear lamina (3)
- nucleotide excision repair (3)
- nystagmus (3)
- obstructive pulmonary disease (3)
- occlusion (3)
- older adults (3)
- olfactory learning (3)
- olfactory memory (3)
- oncolytic viruses (3)
- onkolytische Virotherapie (3)
- ontology (3)
- open abdomen (3)
- operant conditioning (3)
- optical (3)
- optoelectronics (3)
- oral anticancer drugs (3)
- oral bioavailability (3)
- ordinary differential equations (3)
- organic light emitting diodes (3)
- organic molecule (3)
- organic photodiodes (3)
- organic solar cell (3)
- organische Photovoltaik (3)
- organische Solarzelle (3)
- orofacial clefts (3)
- oropharynx (3)
- orthodontics (3)
- oscillation (3)
- oscillations (3)
- osteogene Differenzierung (3)
- osteogenesis (3)
- outpatient (3)
- output elasticities (3)
- ovarian carcinoma (3)
- oxygen/glucose deprivation (3)
- p38 MAPK (3)
- pICln (3)
- paclitaxel (3)
- paleoecology (3)
- palliativ (3)
- pandemic (3)
- parallel imaging (3)
- parastomal hernia (3)
- parents (3)
- pars plana vitrectomy (3)
- particles (3)
- pasture (3)
- patellar tendon (3)
- pathogen (3)
- pathogenicity island (3)
- pathogenicity islands (3)
- pathology (3)
- pathophysiology (3)
- patient education (3)
- patients (3)
- pattern (3)
- pemphigus vulgaris (3)
- pentacene (3)
- peptide receptor radionuclide therapy (3)
- performance evaluation (3)
- periodische Katatonie (3)
- peripheral nerve (3)
- peripheral neuropathy (3)
- peristalsis (3)
- peritonitis (3)
- permeation (3)
- peroxisome (3)
- phage (3)
- phage display (3)
- pharmacodynamics (3)
- pharmacovigilance (3)
- phenomenology (3)
- pheromones (3)
- phonological awareness (3)
- phosphatase (3)
- phosphorus (3)
- photoemission (3)
- photoionization (3)
- photolysis (3)
- photoperiodism (3)
- photosynthesis (3)
- photothrombotic stroke (3)
- phylogenetics (3)
- phytic acid (3)
- phytohormones (3)
- pigmentation (3)
- piperidines (3)
- plant (3)
- plant extract (3)
- plaque (3)
- plasma (3)
- point-of-care (3)
- polarized training (3)
- politics (3)
- pollen foraging (3)
- pollen tube (3)
- pollinator (3)
- poly(2-ethyl-2-oxazoline) (3)
- poly(2-oxazine) (3)
- poly(2-oxazoline) (3)
- poly(2-oxazoline)s (3)
- polymer processing (3)
- polymorphisms (3)
- polyploidy (3)
- poor prognosis (3)
- positive selection (3)
- postoperative nausea and vomiting (3)
- posttranslational modifications (3)
- posture (3)
- potassium channels (3)
- preschool children (3)
- preterm birth (3)
- primary cells (3)
- primary hyperparathyroidism (3)
- primary school (3)
- priming (3)
- prion protein (3)
- pro-inflammatory cytokines (3)
- process mining (3)
- processing fluency (3)
- progenitor cells (3)
- progenitors (3)
- progeria (3)
- programmed cell death (3)
- promoter polymorphism (3)
- prosocial behavior (3)
- prospective study (3)
- prostaglandins (3)
- prostate-specific membrane antigen (PSMA) (3)
- prosthesis (3)
- proteasome (3)
- protected areas (3)
- protein adsorption (3)
- protein crystallography (3)
- protein folding (3)
- protein kinases (3)
- protein phosphorylation (3)
- protein purification (3)
- proteinuria (3)
- proximal gradient method (3)
- psychometrics (3)
- psychopathology (3)
- psychosocial stress (3)
- psychotherapy (3)
- pulse wave velocity (3)
- pyrene (3)
- qPCR (3)
- quality of democracy (3)
- quality of experience (3)
- quantitative analysis (3)
- quantum chemistry (3)
- quantum mechanics (3)
- quantum physics (3)
- quantum well (3)
- quantum wells (3)
- quercetin (3)
- rOCT1 (3)
- radical reactions (3)
- radiography (3)
- radiomics (3)
- radius (3)
- randomized controlled-trial (3)
- randomized trial (3)
- rapid prototyping (3)
- rare diseases (3)
- reaction mechanisms (3)
- reactivation (3)
- reaktive Intermediate (3)
- real time PCR (3)
- rearrangement (3)
- receptor tyrosine kinases (3)
- reference values (3)
- reflection (3)
- regulatory RNA (3)
- regulatory T cell (3)
- rejection (3)
- relaxation (3)
- relief (3)
- remineralization (3)
- remodelling (3)
- renal (3)
- reporter genes (3)
- reporting and data system (3)
- reproductive success (3)
- research (3)
- restriction (3)
- resuscitation (3)
- retrospective analysis (3)
- retroviral vectors (3)
- rhinitis (3)
- rhodesain (3)
- rhodium (3)
- ribosome (3)
- riboswitch (3)
- rice (3)
- rickets (3)
- robustness (3)
- root growth (3)
- rotation (3)
- rubber hand illusion (3)
- safety behavior (3)
- salt (3)
- salthydratic melt (3)
- salvage radiotherapy (3)
- sample (3)
- sarcoidosis (3)
- satellite data (3)
- satellite remote sensing (3)
- scFv (3)
- scanning electron microscopy (3)
- scanning tunneling microscopy (3)
- scleroderma (3)
- secondary lung tumors (3)
- sedimentology (3)
- selectivity (3)
- selenoproteins (3)
- self-assessment (3)
- semantic segmentation (3)
- semi-natural habitats (3)
- semiconductor lasers (3)
- semiotics (3)
- sense of agency (3)
- sensor fusion (3)
- sensory cues (3)
- sensory neurons (3)
- sentinel (3)
- septic (3)
- sequence databases (3)
- sequestration (3)
- seroprevalence (3)
- serotonergic system (3)
- serotonin transporter gene (3)
- serum concentration (3)
- serum resistance (3)
- service (3)
- shoulder arthroplasty (3)
- sialic acid (3)
- side effects (3)
- signal peptides (3)
- signal to noise ratio (3)
- silicon compounds (3)
- single photon emission (3)
- single top production (3)
- single top quark (3)
- single-molecule biophysics (3)
- single-sided deafness (3)
- situation awareness (3)
- sleep bruxism (3)
- sleeve gastrectomy (3)
- small-molecule activation (3)
- smooth muscle (3)
- snRNP (3)
- social (3)
- sodium channel (3)
- spatial attention (3)
- speckle tracking (3)
- speech perception (3)
- speech recognition (3)
- speech recognition test (3)
- sphingolipid (3)
- sphingosine-1-phosphate (3)
- spin polarization (3)
- spin-orbit coupling (3)
- spine (3)
- spiroergometry (3)
- squamous cell carcinoma (3)
- standard model (3)
- startle (3)
- statistical data (3)
- statistics (3)
- stem (3)
- stenosis (3)
- stereoselective synthesis (3)
- stereotactic body radiation therapy (3)
- stereotactic body radiotherapy (3)
- stereotactic irradiation (3)
- stiffness (3)
- stingless bees (3)
- stochastic processes (3)
- stomach (3)
- strains (3)
- strategies (3)
- strategy (3)
- stress resistance (3)
- striatum (3)
- stroke unit (3)
- stroma (3)
- structure-activity relationship (3)
- structured illumination microscopy (3)
- study (3)
- substituent (3)
- subunit (3)
- subventricular zone (3)
- sucrose responsiveness (3)
- superparamagnetism (3)
- superresolution (3)
- suppressor cells (3)
- surface modification (3)
- surface science (3)
- surgical site infection (3)
- survival rate (3)
- survival rates (3)
- susceptibility loci (3)
- swarming (3)
- swine (3)
- synaptic inhibition (3)
- synaptic transmission (3)
- syndrome (3)
- syntaktische Funktion (3)
- syntaktische Struktur (3)
- synthetic methods (3)
- tMCAO (3)
- tapeworm (3)
- targeting (3)
- task switching (3)
- taxation (3)
- teacher education (3)
- team sport (3)
- temozolomide (3)
- temporal binding (3)
- temporal bone (3)
- tendon (3)
- theology (3)
- theoretical chemistry (3)
- theory of mind (3)
- therapeutic strategy (3)
- thermogenesis (3)
- thin film (3)
- thin films (3)
- threat (3)
- three-dimensional imaging (3)
- thyroid gland (3)
- time perception (3)
- time-resolved photoelectron spectroscopy (3)
- timing (3)
- tooth extraction (3)
- top quark (3)
- top quark pair (3)
- topography (3)
- topologische Isolatoren (3)
- toxins (3)
- trabectome (3)
- trade-offs (3)
- trafficking (3)
- tranexamic acid (3)
- trans-splicing (3)
- transcranial magnetic stimulation (3)
- transcriptional control (3)
- transfer (3)
- transgen (3)
- transiente Absorption (3)
- transition (3)
- transkranielle Gleichstromstimulation (3)
- transmission electron microscopy (3)
- transportation (3)
- transtemporal (3)
- trap (3)
- trauma (3)
- treatment outcome (3)
- treatment response (3)
- triglycerides (3)
- tropical ecology (3)
- tumor cells (3)
- tumorigenesis (3)
- tundra (3)
- turbulence (3)
- two-photon absorption (3)
- ulcerative colitis (3)
- ultrafiltration (3)
- umbilical hernia (3)
- university library (3)
- upper extremity (3)
- urban (3)
- urbanization (3)
- uremic toxin (3)
- urinary tract infections (3)
- usability (3)
- use (3)
- user-centered design (3)
- vaccines (3)
- vacuole (3)
- vandetanib (3)
- vascular (3)
- vegetation (3)
- vertical transmission (3)
- vibration (3)
- video analysis (3)
- viral load (3)
- viral replication (3)
- virology (3)
- virtual environments (3)
- virtuelle Realität (3)
- virtuelles Screening (3)
- visual acuity (3)
- visual orientation (3)
- von Willebrand factor (3)
- waggle dance (3)
- water purification (3)
- weight gain (3)
- whole exome sequencing (3)
- wrist (3)
- xenotransplantation (3)
- xerostomia (3)
- yoga (3)
- zeitaufgelöste Spektroskopie (3)
- zinc oxide (3)
- Ägypten <Altertum> (3)
- Ängstliche Depression (3)
- Ästhetik (3)
- Ästhetische Bildung (3)
- Ätiologie (3)
- Ökosystem (3)
- Österreich (3)
- Übergangsmetallverbindungen (3)
- Übung (3)
- α-synuclein (3)
- γδ T cells (3)
- "-omics" (2)
- (Ga (2)
- (Ga,Mn)As (2)
- 1,2-Azaborinine (2)
- 10-bis(dicarboximide)> (2)
- 11C-HED (2)
- 123I-mIBG (2)
- 123I-metaiodobenzylguanidine (2)
- 177Lu (2)
- 18F-FDS (2)
- 19th century (2)
- 2"-> (2)
- 2':6' (2)
- 2-APB (2)
- 2015 (2)
- 2B (2)
- 2Dimensionale Spektroskopie (2)
- 3 D bioprinting (2)
- 3 Tesla (2)
- 3-DPG (2)
- 31P-MRS (2)
- 3D - rapid prototyping (2)
- 3D Bioprinting (2)
- 3D Pulverdruck (2)
- 3D Tumormodell (2)
- 3D analysis (2)
- 3D fluoroscopy (2)
- 3D in vitro model (2)
- 3D model generation (2)
- 3D tumour model (2)
- 3D-Bildgebung (2)
- 3D-Gewebemodell (2)
- 3D-Kultur (2)
- 3D-Modell (2)
- 3D-Rekonstruktion (2)
- 3D-Ultraschall (2)
- 3D-printed tooth (2)
- 4 (2)
- 4-0xadiazine-2-carboxylate (2)
- 4-Aminobiphenyl (2)
- 4-HNE (2)
- 4-aminobiphenyl (2)
- 4:9 (2)
- 4D flow (2)
- 5-Azacytidine (2)
- 5-Azadeoxycytidin (2)
- 5-FU (2)
- 5-HT transporter (2)
- 5-HT1A receptor (2)
- 5-azadeoxycytidine micronucleus (2)
- 5G (2)
- 6 (2)
- 68Ga-DOTATATE (2)
- 7 T (2)
- 7T (2)
- 8p22 (2)
- A1 adenosine receptors (2)
- A20 (2)
- AAA (2)
- AAA-Knochen (2)
- ABCG2 (2)
- ACID (2)
- ADAM9 (2)
- ADC (2)
- ADMA (2)
- ADST (2)
- AFLP (2)
- AICD (2)
- AKT1 (2)
- ALCL (2)
- ALMT (2)
- AMACR (2)
- AMADEUS (2)
- AMSOL (2)
- ANOVA (2)
- AP-1 (2)
- APC (2)
- AQP4 (2)
- ARONJ (2)
- ASCA (2)
- ASCs (2)
- ASM (2)
- ATF4 (2)
- ATF5 (2)
- ATM (2)
- ATRT (2)
- Ab interno trabeculectomy (2)
- Ab-initio-Rechnung (2)
- Abelsche Gruppe (2)
- Ablenkung (2)
- Abrieb (2)
- Abschlussprüfung (2)
- Abscisic Acid (2)
- Abscisic acid (2)
- Absolute Konfiguration (2)
- Absolutquantifizierung (2)
- Absorption (2)
- Abstoßung (2)
- Abszess (2)
- Abtreibung (2)
- Acetaminophen (2)
- Acetylation (2)
- Acetylcystein (2)
- Acetylierung (2)
- Achilles (2)
- Achtsamkeit (2)
- Achtsamkeitsbasiertes Training (2)
- Ackerbohne (2)
- Acromyrmex fracticornis (2)
- Actin nucleation (2)
- Actinomyceten (2)
- Active Galactic Nuclei (2)
- Active galactic nucleus (2)
- Activity (2)
- Acute Kidney Injury (2)
- Acute lymphocytic leukaemia (2)
- Acute myeloid leukemia (2)
- Acute myeloid leukemia (AML) (2)
- Adamov (2)
- Additive Manufacturing (2)
- Adenocarcinom (2)
- Adenosine receptor (2)
- Adenylatcyclase (2)
- Aderhaut (2)
- Aderhautmelanom (2)
- Adhesion GPCR (2)
- Adhesion-GPCR (2)
- Adhäsionsmoleküle (2)
- Adhäsivbrücke (2)
- Adhäsive Restauration (2)
- Adhäsivfraktur (2)
- Adipogenesis (2)
- Adipokine (2)
- Adiponektin (2)
- Adipositaschirurgie (2)
- Adjuvant (2)
- Adjuvante Therapie (2)
- Adolescence (2)
- Adrenostatika (2)
- Adulte Neurogenese (2)
- Adults (2)
- Advanced glycosylation end products (2)
- Aequos G1 (2)
- Aerosol (2)
- Aflatoxin (2)
- African Trypanosomes (2)
- African trypanosomes (2)
- Afrikanische Union (2)
- Agalsidase beta (2)
- Agent (2)
- Agent <Informatik> (2)
- Agent <Künstliche Intelligenz> (2)
- Agoraphobia (2)
- Agrobacterium (2)
- Akkadisch (2)
- Akkulturation (2)
- Aktiv (2)
- Akustisch evoziertes Potenzial (2)
- Akute Extremitätenischämie (2)
- Akutes ischämisches Nierenversagen (2)
- Akzeptor <Chemie> (2)
- Alain ; Boudjedra (2)
- Alcohol (2)
- Aldosterone (2)
- Aldosteronsynthaseinhibitor (2)
- Algen (2)
- Algerien (2)
- Algorithm (2)
- Alignment (2)
- Alkoholkonsum (2)
- Alkoxysilane (2)
- Allelische Verlustanalyse (2)
- Allgemeines Gleichgewichtsmodell (2)
- Allgemeinmedizin (2)
- Alloantigen (2)
- Allogene Stammzelltransplantation (2)
- Allograft rejection (2)
- Allosterie (2)
- Allosterischer Effektor (2)
- Allotransplantation (2)
- Alltag (2)
- Alpha-2-Rezeptor (2)
- Alternans (2)
- Alternative (2)
- Altersbestimmung (2)
- Altersdepression (2)
- Altersvorsorge (2)
- Altfranzösisch (2)
- Aluminafluorene (2)
- Aluminiumnitrid (2)
- Aluminiumverbindungen (2)
- Alveolarmakrophagen (2)
- Alzheimer's Disease (2)
- Amazon Molly (2)
- Ames test (2)
- Amino Acids (2)
- Aminobisphosphonate (2)
- Aminobuttersäure <gamma-> (2)
- Aminoglykoside (2)
- Ammoniten (2)
- Amplification (2)
- Amputation (2)
- Amyotrophe Lateralsklerose (2)
- Analfistel (2)
- Anaplastisches Schilddrüsenkarzinom (2)
- Anastomosenheilung (2)
- Anastomoseninsuffizienz (2)
- Anatolien (2)
- Androgene (2)
- Aneuploidy (2)
- Angabe (2)
- Angewandte Mikrobiologie (2)
- Angiotensin-II-Blocker (2)
- Angstsyndrom (2)
- Anidulafungin (2)
- Animal models (2)
- Anisotrope Diffusion (2)
- Anode (2)
- Anoplolepis gracilipes (2)
- Antarctic ice sheet (2)
- Antarktis (2)
- Antenne (2)
- Anthracen (2)
- Anthropometrie (2)
- Anthropozän (2)
- Anti-k Jet (2)
- Antiaromatizität (2)
- Antibiotic (2)
- Antibiotics (2)
- Antibiotikafreisetzung (2)
- Antibiotikaprophylaxe (2)
- Antibiotikaresistenz (2)
- Antibiotikaresistenzen (2)
- Antidepressivum (2)
- Antiepileptika (2)
- Antigen CD14 (2)
- Antigen CD19 (2)
- Antigen CD25 (2)
- Antikenrezeption (2)
- Antikoagulation (2)
- Antikonvulsiva (2)
- Antikörper-Fusionsproteine (2)
- Antimonide (2)
- Antimonverbindungen (2)
- Antimykotikaresistenz (2)
- Antipsychotics (2)
- Antisense (2)
- Antisense RNA (2)
- Antisepsis (2)
- Anton Ulrich, Braunschweig-Lüneburg, Herzog (2)
- Anwendung (2)
- Anwendungssoftware (2)
- Anxiety sensitivity (2)
- Anästhesiologie (2)
- Anästhetika-induzierte Postkonditionierung (2)
- Anästhetika-induzierte Präkonditionierung (2)
- Aortendissektion (2)
- Aortenklappe (2)
- Aortic valve stenosis (2)
- Aortokoronarer Bypass (2)
- Apolipoprotein (2)
- Apologie (2)
- Apology (2)
- Apoplast (2)
- Appetitlosigkeit (2)
- Approach-Avoidance-Task (2)
- Approximation (2)
- Aptamer (2)
- Aquaporine (2)
- Arabismus (2)
- Arachidonsäure (2)
- Arbeitsbelastung (2)
- Arbeitsrecht (2)
- Archaea (2)
- Architekt (2)
- Argentina (2)
- Arginine (2)
- Argumentation (2)
- Aristeas (2)
- Aristeas-Brief (2)
- Arno Schmidt (2)
- Aromaten (2)
- Aromaticity (2)
- Aromatizität (2)
- Arrestine (2)
- Arten-Energy-Theory (2)
- Artenreichtum (2)
- Arteria carotis interna (2)
- Arterielle Gefäßsteifigkeit (2)
- Arterielle Verschlusskrankheit (2)
- Arteriosclerosis (2)
- Arthroplastik (2)
- Arthur (2)
- Arzneibuch (2)
- Arzt (2)
- Asien (2)
- Aspartatproteasen (2)
- Aspergillosis (2)
- Aspirin (2)
- Assembly (2)
- Association (2)
- Associative learning (2)
- Assoziatives Lernen (2)
- Astronomie (2)
- Astrozyt (2)
- Astrozyten (2)
- Asylrecht (2)
- AtSUC4 (2)
- Ataciguat (2)
- Atemstörung (2)
- Atharvaveda (2)
- Atomic and molecular interactions with photons (2)
- Atrophie (2)
- Attention (2)
- Attention-deficit/hyperactivity disorder (2)
- Attenuierung (2)
- Audiovisuelle Medien (2)
- Audit sampling (2)
- Auditor Independence (2)
- Auditory brainstem responses AER (2)
- Auditory steady-state responses ASSR (2)
- Aufführung (2)
- Aufgabenorientierung (2)
- Aufgabenwechsel (2)
- Aufmerksamkeitsdefizit-/Hyperaktivitätsstörung (2)
- Aufmerksamkeitskontrolle (2)
- Aufmerksamkeitslenkung (2)
- Aufmerksamkeitsverzerrung (2)
- Augenbewegung (2)
- Augenfolgebewegung (2)
- Augenhintergrund (2)
- Augenkrankheit (2)
- Augenlid (2)
- Ausfallsicheres System (2)
- Ausfallsicherheit (2)
- Ausgrabungen (2)
- Aushärtung (2)
- Auskunftsdienst (2)
- Ausländerstudium (2)
- Austauschreaktion (2)
- Autism spectrum disorders (2)
- Autismus-Spektrum-Störung (2)
- Auto-Scaling (2)
- Autobiographie ; Robbe-Grillet (2)
- Autogene Transplantation (2)
- Autologous hematopoietic stem cell transplantation (2)
- Autophagie <Physiologie> (2)
- Autoradiographie (2)
- Autorenlesung (2)
- Autorotation (2)
- Autotransporterprotein (2)
- Außenpolitik (2)
- Außerschulische Bildung (2)
- Avemar (2)
- Aversive Konditionierung (2)
- Awareness (2)
- Axion (2)
- Axon degeneration (2)
- Axonal degeneration (2)
- Azaborinine (2)
- Azide (2)
- Azoalkene (2)
- B cell differentiation (2)
- B cell receptors (2)
- B-Lymphozyten-Rezeptor (2)
- B-N-Kupplung (2)
- B-Zelldifferenzierung (2)
- B-scan-Ultraschallkardiographie (2)
- BAD (2)
- BALF (2)
- BAV-Förderbetrag (2)
- BBCH (2)
- BCL6 (2)
- BCMA (2)
- BDG (2)
- BDNF stimulation (2)
- BERAphon (2)
- BGK approximation (2)
- BH3-only proteins (2)
- BK-Kanal (2)
- BMI (2)
- BMP signaling (2)
- BMP variants (2)
- BMPR-IA (2)
- BNIP3 (2)
- BNP (2)
- BOLD signal (2)
- BPD (2)
- BRCA2 (2)
- BRENDA (2)
- BTN3 (2)
- Bacillus (2)
- Bacillus megaterium (2)
- Bacterial infection (2)
- Bacterial meningitis (2)
- Bacterial pathogens (2)
- Bakterielle Hirnhautentzündung (2)
- Bakteriengift (2)
- Balanced lethal System (2)
- Balanced lethal Systeme (2)
- Ballistischer Transport (2)
- Bandstruktur (2)
- Barbaricum (2)
- Bariatric surgery (2)
- Bariumtitanat (2)
- Barrett's esophagus (2)
- Barrett-Ösophagus (2)
- Barrettösophagus (2)
- Barrieren (2)
- Basalmembran (2)
- Base text (2)
- Basilius, Caesariensis (2)
- Bauchaorta (2)
- Bauchwand (2)
- Baumkrone (2)
- Baumwollratte (2)
- Bcl-2 Familie (2)
- Bcl-2 family (2)
- Beamtenrecht (2)
- Beatmung (2)
- Bedürfnisse (2)
- Bee abundance (2)
- Bees (2)
- Befindlichkeit (2)
- Befragung (2)
- Begabtenförderung (2)
- Begriff (2)
- Behindertenbeauftragte (2)
- Belastungselektrokardiogramm (2)
- Beliefs (2)
- Belyi map (2)
- Benchmark (2)
- Benfotiamin (2)
- Benin (2)
- Benutzeroberfläche (2)
- Benutzerschnittstelle (2)
- Benzene (2)
- Benzochinone (2)
- Benzvalen (2)
- Beobachter (2)
- Berchtesgaden (2)
- Berichterstattung (2)
- Berlin (2)
- Berufsanfang (2)
- Beschneidung (2)
- Beschäftigung (2)
- Bestandsmanagement (2)
- Besteuerung (2)
- Bestimmung (2)
- Bestäuber (2)
- Bestäubungsökologie (2)
- Besucherverhalten (2)
- Beta-2-Rezeptor (2)
- Beta-Hydroxybutyrat (2)
- Beta-catenin (2)
- Betablocker (2)
- Betreuungsrecht (2)
- Betrieb (2)
- Betriebsformenwandel (2)
- Betriebsrente (2)
- Betriebssystem (2)
- Bewegungsapparat (2)
- Bi2Se3 (2)
- Bibel (2)
- Bibel. Judit (2)
- Bibliografie (2)
- Bienenbrut (2)
- Big Five (2)
- Biholomorphe Abbildung (2)
- Bilanzierung (2)
- Bildbetrachtung (2)
- Bildhauer (2)
- Bildnerisches Gestalten (2)
- Bindeproteine (2)
- Bindestelle (2)
- Binomialverteilung (2)
- BioGlue (2)
- BioID (2)
- BioVaSc (2)
- Bioaktive Verbindungen (2)
- Bioaktivität (2)
- Bioassay (2)
- Bioavailability (2)
- Biochemistry (2)
- Biodiversity (2)
- Biodruck (2)
- Biografie (2)
- Biographisches Interview (2)
- Bioink (2)
- Bioinks (2)
- Biokatalyse (2)
- Biokompatibel (2)
- Biologika (2)
- Biologische Schädlingsbekämpfung (2)
- Biologisches System (2)
- Biomechanics (2)
- Biomedicine (2)
- Biomembran (2)
- Biometrie (2)
- Biomolekül (2)
- Bioorganik (2)
- Bioorganische Chemie (2)
- Bioreactor (2)
- Biosphärenreservat Rhön (2)
- Biostatistik (2)
- Biosynthesis (2)
- Biotechnologische Industrie (2)
- Bismuthene (2)
- Bismutselenide (2)
- Bismutverbindungen (2)
- Bisphenol A (2)
- Bisphosphonates (2)
- Bispidinderivate (2)
- Bitopische Liganden (2)
- Bivalves (2)
- Blake (2)
- Blastozyste (2)
- Bleiakkumulator (2)
- Blinddarmentzündung (2)
- Blood pressure (2)
- Blood-brain barrier (2)
- Blumeria graminis (2)
- Blut-Nerven-Barriere (2)
- Blut-Nerven-Schranke (2)
- Blutalkohol (2)
- Blutkontakt (2)
- Blutplättchen (2)
- Bmi1 (2)
- Board of directors (2)
- Bocca (2)
- Bodenfeuchte (2)
- Bodengeografie (2)
- Bodenwasser (2)
- Body weight (2)
- Body-Mass-Index (2)
- Bodyplethysmographie (2)
- Bombus (2)
- Bombus terrestris (2)
- Bond Activation (2)
- Bone marrow (2)
- Bone morphogenetic protein (2)
- Bone-Lock-System (2)
- Bone-marrow-transplantation (2)
- Bor-Stickstoff-Verbindungen (2)
- Bor-Übergangsmetallkomplexe (2)
- Boranes (2)
- Bordetella petrii (2)
- Borkenkäfer (2)
- Borolderivate (2)
- Borrelia burgdorferi (2)
- Borrelien (2)
- Borverbindungen (2)
- Borylanion (2)
- Borylenkomplex (2)
- Borylradikale (2)
- Bose-Einstein-Kondensation (2)
- Box-Jenkins-Verfahren (2)
- Box–Jenkins Program (2)
- Bradykinin (2)
- Brain endothelial cells (2)
- Brain natriuretic Peptide (2)
- Brainstem-Evoked-Response-Audiometry BERA (2)
- Brassica napus (2)
- Brazil (2)
- Breast-cancer (2)
- Breast-tumors (2)
- Breastcancer (2)
- Bronchialkarzinom (2)
- Bruchfestigkeit (2)
- Bruchverhalten (2)
- Brushite (2)
- Brust (2)
- Brustaorta (2)
- Brustbein (2)
- Brutbiologie (2)
- Buchpreis (2)
- Bulimia nervosa (2)
- Bullöses Pemphigoid (2)
- Bundesverfassungsgericht (2)
- Burst (2)
- Business Improvement District (2)
- Business Improvement Districts (2)
- Butyrylcholinesterase (2)
- BvgAS-System (2)
- Bärtierchen (2)
- Bürgertum (2)
- Bū-Ǧadra, Rašīd (2)
- C-F bond activation (2)
- C-H activation (2)
- C-RAF (2)
- C-X-C motif chemokine receptor 4 (2)
- C-coupled naphthylisoquinoline alkaloids (2)
- C-reaktives Protein (2)
- C. callunae (2)
- C. efficiens (2)
- C. glutamicum (2)
- C/Si-Austausch (2)
- C/Si-Bioisosteric Investigations (2)
- C/Si-Bioisostric Investigations (2)
- C1-Inhibitor (2)
- C1-inhibitor (2)
- C3 (2)
- C57BL/6 mice (2)
- C5a (2)
- C6 (2)
- C60 (2)
- CA19-9 (2)
- CABG (2)
- CAD-CAM (2)
- CADe (2)
- CAIPIRINHA (2)
- CARS-Spektroskopie (2)
- CBCT (2)
- CCL4 (2)
- CCN1 (2)
- CCR4 (2)
- CD117 (2)
- CD20 (2)
- CD274 (2)
- CD28 superagonist (2)
- CD28-Superagonist (2)
- CD28-superagonist (2)
- CD30 (2)
- CD38 (2)
- CD4(+) T-cells (2)
- CD4+ (2)
- CD46 (2)
- CD70 (2)
- CD8 T-Zellen (2)
- CD8+ T cells (2)
- CD8+ T-Zellen (2)
- CD83mRNA (2)
- CD84 (2)
- CDC42 (2)
- CDI (2)
- CDL (2)
- CHO-Zelle (2)
- CHO-Zellen (2)
- CI (2)
- CK2 (2)
- CKD (2)
- CLL (2)
- CNN (2)
- CNS cancer (2)
- CNS disease (2)
- CNS disorders (2)
- CORDEX Africa (2)
- CORM (2)
- CP-Parität (2)
- CRC (2)
- CRE (2)
- CREB (2)
- CSI (2)
- CSS (2)
- CSVD (2)
- CTEPH (2)
- CVD-Verfahren (2)
- CX3CR1 (2)
- CXCL10 (2)
- CXCL12 (2)
- CXCL13 (2)
- CXCR2 (2)
- CXCR7 (2)
- CYP11B1 (2)
- CYP24A1 (2)
- CYP2W1 (2)
- CaMKII (2)
- Ca\(^{2+}\) signalling (2)
- Caco2 cells (2)
- Cadherin (2)
- Cadherin-13 (2)
- Cadmiumsulfid (2)
- Cadmiumtellurid (2)
- Calcitonin (2)
- Calciumion (2)
- Calearo (2)
- Calpain (2)
- Cambrian (2)
- Canada (2)
- Cancer immunotherapy (2)
- Cancer treatment (2)
- Capacity Management (2)
- Capecitabin (2)
- Capillary Electrophoresis (2)
- Carbamate (2)
- Carbazolderivate (2)
- Carbenkomplexe (2)
- Carbocations (2)
- Carborane (2)
- Carcinogenität (2)
- Cardiac (2)
- Cardiac Surgery (2)
- Cardiac hypertrophy (2)
- Cardiomyocyte (2)
- Cardiovascular disease (2)
- Cardiovascular diseases (2)
- Cardiovascular risk factors (2)
- Carfilzomib (2)
- Carnica-Biene (2)
- Cartilage (2)
- Cartilage Tissue Engineering (2)
- Cartilage regeneration (2)
- Cascading Style Sheets (2)
- Caspase-1 (2)
- Caspases (2)
- Catechine (2)
- Catechol-0-Methyltransferase (2)
- Cathepsin (2)
- Caveolae (2)
- Cayley graph (2)
- Cdc42 (2)
- Cdu1 (2)
- Cefotaxim (2)
- Cell (2)
- Cell adhesion (2)
- Cell migration (2)
- Cell therapy (2)
- Cellculture (2)
- Cement (2)
- Cephalometric (2)
- Cephalosporine (2)
- Cerebellum (2)
- Cerlegierung (2)
- ChIP-sequencing (2)
- ChR2 (2)
- Chagas disease (2)
- Chaotisches System (2)
- Charcot-Marie-Tooth disease (2)
- Checkpoint-Inhibitor (2)
- Chelatbildner (2)
- Chemical Synthesis (2)
- Chemische Analyse (2)
- Chemische Reaktion (2)
- Chemisorption (2)
- Chemokinrezpetor (2)
- Chemoresistenz (2)
- Chemotherapieresistenz (2)
- Childhood (2)
- Childhood medulloblastoma (2)
- Chili RNA Aptamer (2)
- Chimerism (2)
- Chirale Verbindungen (2)
- Chirp-Reiz (2)
- Chirurgiegeschichte (2)
- ChlaDUB1 (2)
- Chlamydia pneumoniae (2)
- Chlorinderivate (2)
- Cholesterol (2)
- Cholinesterase (2)
- Chondrogenese (2)
- Chondrogenesis (2)
- Chondrogenic Differentiation (2)
- Chorasan (2)
- Christentum (2)
- Christianity (2)
- Chromatin structure (2)
- Chromosom 8 (2)
- Chromosomenanalyse (2)
- Chromosomenverlust (2)
- Chronic heart failure (2)
- Chronic kidney disease (2)
- Chronische Nierenerkrankung (2)
- Chronotrope Inkompetenz (2)
- Chrysididae (2)
- Chrétien <de Troyes> (2)
- Ciclosporin (2)
- Circadian clock (2)
- Circadianer Rhythmus (2)
- Circular-Dichroismus (2)
- Cirl (2)
- Citalopram (2)
- Cl Lowe limit (2)
- Claudin (2)
- Claudin-1 (2)
- Claudine <Biologie> (2)
- Cleft (2)
- Clinical Neuroradiology (2)
- Clinical trial (2)
- Clostridium-difficile-Infektion (2)
- Cloud Gaming (2)
- Cluster <Wirtschaft> (2)
- Cluster C Persönlichkeitsstörungen (2)
- Clusteranalyse (2)
- Co-Kultur (2)
- Co-culture (2)
- Cobalt (2)
- Cochlea Implantat (2)
- Code examples (2)
- Codierung (2)
- Coffin-Lowry syndrome (2)
- Cofilin (2)
- Cognition (2)
- Cognitive conflict (2)
- Colombia (2)
- Colonization (2)
- Colorectal Cancer (2)
- Colorectal carcinoma (2)
- Columnare Phase (2)
- Combination (2)
- Comet assay (2)
- Comet-Assay (2)
- Compliance (2)
- Compliance <Patient> (2)
- Composite international diagnostic interview (2)
- Computed tomography (2)
- Computerphysik (2)
- Concealed Information Test (2)
- Conductivity (2)
- Confidence interval (2)
- Conformal field theory (2)
- Congo (2)
- Conical Intersections (2)
- Conjugation (2)
- Connexin (2)
- Conservation (2)
- Consistent partial least squares (2)
- Constant Score (2)
- Constant score (2)
- Constant-Score (2)
- Constraints (2)
- Contactin-1 (2)
- Contaminants (2)
- Content Management (2)
- Continuous Performance Test (2)
- Controllability (2)
- Controlling (2)
- Convolutional Neural Network (2)
- Coordination Chemistry (2)
- Copeptin (2)
- Copolymerisation (2)
- Copyright (2)
- Corannulene (2)
- Corporate Social Responsibility (2)
- Corpus (Linguistics) (2)
- Corpus striatum (2)
- Correlated Fermions (2)
- Correlative microscopy (2)
- Cortactin (2)
- Cortex (2)
- Corti-Organ (2)
- Corticosteroide (2)
- Cortison (2)
- Corynebacterium callunae (2)
- Corynebacterium efficiens (2)
- Corynebacterium glutamicum (2)
- Coupled Cluster (2)
- Covid-19 Pandemie (2)
- CpG (2)
- CpG-ODN (2)
- Crab-Nebel (2)
- Craniomandibuläre Dysfunktion (2)
- Craniopharyngioma (2)
- Craving (2)
- Crohn´s disease (2)
- Crohn’s disease (2)
- Cross-section (2)
- Crosslinking (2)
- Crosstalk (2)
- Crouzon (2)
- Crush (2)
- Cryo-EM (2)
- Cryptochrom (2)
- Crystal Structure (2)
- CsrA (2)
- CuPc (2)
- Cue-Reaktivität (2)
- Cuprate (2)
- Cushing’s disease (2)
- Cuticle (2)
- Cuticular waxes (2)
- Cyaninfarbstoff (2)
- Cyclische Verbindungen (2)
- Cyclization (2)
- Cyclo-GMP-Derivate (2)
- Cyclonucleotide (2)
- Cyclopentadienderivate (2)
- Cyclophosphamid (2)
- Cyclophosphamide (2)
- Cymantren (2)
- Cys-loop receptor (2)
- Cysteinderivate (2)
- Cytochrom C (2)
- Cytochrom P-450 (2)
- Cytochrome C (2)
- Cytokeratin (2)
- Cytokeratine (2)
- Cytoplasma (2)
- Cytotoxicity (2)
- Césaire, Aimé (2)
- D-Norm (2)
- D665 (2)
- DAPI staining (2)
- DASH (2)
- DCIS (2)
- DHAP (2)
- DIRA (2)
- DM-domain gene (2)
- DM2 (2)
- DMS (2)
- DNA Binding (2)
- DNA Methylation (2)
- DNA Repair (2)
- DNA Reparatur (2)
- DNA Schaden (2)
- DNA antibodies (2)
- DNA barcoding (2)
- DNA delivery (2)
- DNA double-strand break (2)
- DNA fingerprinting (2)
- DNA helicase (2)
- DNA methyltransferases (2)
- DNA storage (2)
- DNA-Binding (2)
- DNA-PK (2)
- DNA-Reparaturgene (2)
- DNA-Schäden (2)
- DNA-Typisierung (2)
- DNA-repair (2)
- DNA-typing (2)
- DNA/RNA sensors (2)
- DNMT3A (2)
- DNMT3B (2)
- DNS-Strangbruch (2)
- DNS-Topoisomerasen (2)
- DOT1 (2)
- DOTATOC (2)
- DRD4 (2)
- DREAM (2)
- DROSHA (2)
- DSM-IV (2)
- DUB (2)
- Dacron (2)
- Damage (2)
- Dante, Alighieri (2)
- Dark-Matter (2)
- Darmepithel (2)
- Darmwandnervensystem (2)
- Darstellungsmatrix (2)
- Data-Warehouse-Konzept (2)
- Database (2)
- Datenfusion (2)
- Datenschutz (2)
- Dativ (2)
- Debonding (2)
- Decision Support Systems (2)
- Dectin-1 (2)
- Deep Learning (2)
- Deep sequencing (2)
- Deep sternal wound infection (2)
- Deformationsquantisierung (2)
- Deformität (2)
- Defäkographie (2)
- Dehydrokupplung (2)
- Delay Discounting (2)
- Deletion <Genetik> (2)
- Delta-Valve (2)
- Demokratische Republik Kongo (2)
- Demyelination (2)
- Demyelinisierung (2)
- Dentale Implantate (2)
- Dentalwerkstoff (2)
- Dentin (2)
- Dentinadhäsivsysteme (2)
- Dentinhaftvermittler (2)
- Dependenz (2)
- Depolarisation (2)
- Deregulierung (2)
- Derivation (2)
- Derivatisierung (2)
- Desertifikation (2)
- Desmoglein (2)
- DeuCze-Korpus (2)
- Deutsche Sprachwissenschaft (2)
- Deutsches Sprachgebiet (2)
- Deutschland (Bundesrepublik) (2)
- Deutschland / Stammzellgesetz (2)
- Dezentrale Regelung (2)
- Dezentralisierung (2)
- Diabetes mellitus Typ 2 (2)
- Diabetic polyneuropathy (2)
- Diagnosesystem (2)
- Diagnostic medicine (2)
- Dialekt (2)
- Dialektologie (2)
- Dialysepatienten (2)
- Dialysis (2)
- Diamiktit (2)
- Diboran (2)
- Diboret (2)
- Diborierung (2)
- Dichtegewichtung (2)
- Dickenmessung (2)
- Diels-Alder-Reaktion (2)
- Diethylstilbestrol (2)
- Difenidol (2)
- Differential effects of stressors (2)
- Differentialdiagnose (2)
- Differenziertes Schilddrüsenkarzinom (2)
- Differenzierungspotential (2)
- Diffusion Tensor Imaging (2)
- Diffusion coefficient (2)
- Diffusionsgewichtete Magnetresonanztomografie (2)
- Digital Elevation Model (2)
- Digital Religions Education (2)
- Digitale Signalverarbeitung (2)
- Digitalization (2)
- Dihydroborane (2)
- Dihydrooxazole (2)
- Dilatative Kardiomyopathie (2)
- Dioncophyllaceae (2)
- Diphosphonate (2)
- Direkte Demokratie (2)
- Dirichlet-Reihe (2)
- Disease (2)
- Diseases (2)
- Diskriminanzanalyse (2)
- Diskriminierung (2)
- Diskursmarker (2)
- Disney (2)
- Dispergierung (2)
- Distress (2)
- Distributed computing (2)
- Disulfidbrücken (2)
- Djebar, Assia (2)
- Dobutamin-Stressechokardiographie (2)
- Dodecaborane (2)
- Dominanz (2)
- Domäne (2)
- Donator <Chemie> (2)
- Dopaminerge Nervenzelle (2)
- Dopaminrezeptor (2)
- Dopaminstoffwechsel (2)
- Dopamintransporter (2)
- Doppelbesteuerung (2)
- Doppelkronen (2)
- Doppelverbeitragung (2)
- Dorsal Root Ganglion (2)
- Dorsal root ganglion (2)
- Dose response (2)
- Dose-response relationship (2)
- Dosimetry (2)
- Dosisreduktion (2)
- Dot-Depth Problem (2)
- Down-Syndrom (2)
- Dreidimensionale Bildverarbeitung (2)
- Dreifachbindung (2)
- Drogen (2)
- Drug design (2)
- Drug development (2)
- Drylands (2)
- Dsg2 (2)
- Dual-Source-Computertomographie (2)
- Duchenne (2)
- Duodenopankreatektomie (2)
- Durchblutungsmessung (2)
- Dwyka (2)
- Dyade (2)
- Dyes (2)
- Dystonia (2)
- Dämpfung (2)
- Dämpfungseigenschaften (2)
- Dünen (2)
- Dünndarmmotilität (2)
- Dünndarmtransplantat (2)
- E-Commerce (2)
- E-Government (2)
- E-learning (2)
- E. coli (2)
- E. coli Nissle (2)
- E. coli serotype 06 (2)
- EAA (2)
- EAAC1 (2)
- EBRA (2)
- ECMO-Therapie (2)
- EDA-NOCV (2)
- EEA (2)
- EF (2)
- EF-1A (2)
- EGF-Rezeptor (2)
- EGF-receptor (2)
- EGFP (2)
- EORTC (2)
- ERI (2)
- ERK signaling (2)
- ERT (2)
- ETiCS (2)
- EU (2)
- EUROASPIRE (2)
- EW (2)
- EXKK (2)
- EZH2 (2)
- Early Basso Continuo (2)
- Early Music (2)
- Early Neolithic (2)
- Early-onset (2)
- Earnings Quality (2)
- Echinococcosis (2)
- Ecological Momentary Assessment (2)
- Edelmetall (2)
- Edition (2)
- Efavirenz (2)
- Effektive Theorie (2)
- Effizienter Algorithmus (2)
- Effizienzsteigerung (2)
- Effluxpumpen (2)
- Ehrenamt (2)
- Eierstocktumor (2)
- Eindringerkennung (2)
- Einführung (2)
- Eingeweidewürmer (2)
- Einkauf (2)
- Einmodenlaser (2)
- Einsamkeit (2)
- Einsatzfahrten (2)
- Einsilbersprachverständnistest (2)
- Einwanderung (2)
- Einzelphotonenquelle (2)
- Einzelzellanalyse (2)
- Eiparasitismus (2)
- Eisenoxid-Nanopartikel (2)
- Ekel (2)
- Elderly (2)
- Electroencephalography (2)
- Electromagnon (2)
- Electron Transfer (2)
- Electronic commerce (2)
- Electronic spectroscopy (2)
- Elektrische Leitfähigkeit (2)
- Elektrizitätsverbrauch (2)
- Elektroakupunktur (2)
- Elektroimpedanztomographie (2)
- Elektromagnon (2)
- Elektromobilität (2)
- Elektron-Elektron-Streuung (2)
- Elektronendichteverteilung (2)
- Elektronenflüssigkeit (2)
- Elektronenstrahllithographie (2)
- Elektronenzustand (2)
- Elektronische Anregung (2)
- Elektronische Spektroskopie (2)
- Elektronisches Publizieren (2)
- Elektrophysiologische Untersuchung (2)
- Elektrospinning (2)
- Elektrostimulation (2)
- Elementarteilchen (2)
- Elfenbeinküste (2)
- Elite Controller (2)
- Elmex (2)
- Elternarbeit (2)
- Elterntraining (2)
- Embolisation (2)
- Emotion regulation (2)
- Emotional processing (2)
- Empathie (2)
- Empirical Analysis (2)
- Empirische Forschung (2)
- Emulsion (2)
- Enantiomere (2)
- Enantiomerentrennung (2)
- Enantioselectivity (2)
- Encephalopathia hepatica (2)
- End-of-Life Care (2)
- End-zu-End-Anastomose (2)
- Endocannabinoide (2)
- Endocytosis (2)
- Endodermis (2)
- Endophytische Pilze (2)
- Endophänotyp (2)
- Endoplasmatisches Retikulum (2)
- Endoribonuklease P (2)
- Endoskopie (2)
- Endosonographie (2)
- Endothelial cells (2)
- Endothelial dysfunction (2)
- Endothelin (2)
- Endotracheale Intubation (2)
- Energie (2)
- Energierecht (2)
- Energiereiches Teilchen (2)
- Energiespeicher (2)
- Energiestoffwechsel (2)
- Engadin (2)
- England (2)
- Englischunterricht (2)
- Enol Iactones (2)
- Enoxaparin (2)
- Enoyl-ACP-Reduktase (2)
- Enoyl-acyl-carrier-protein-Reductase (2)
- Entamoeba histolytica (2)
- Entanglement (2)
- Enterococcus faecium (2)
- Enterprise-Resource-Planning (2)
- Entropie (2)
- Entscheidbarkeit (2)
- Entscheidungen (2)
- Entscheidungsneutralität (2)
- Entscheidungsprozess (2)
- Entscheidungssammlung (2)
- Entscheidungsverhalten (2)
- Entstehungsgeschichte (2)
- Entzündungsparameter (2)
- Entzündungsreaktion (2)
- Entzündungsschmerz (2)
- Epidemiology (2)
- Epigenese (2)
- Epik (2)
- Epiphyten (2)
- Epitaxieschicht (2)
- Epithelial-mesenchymale Transition (2)
- Epithelkörperchen (2)
- Epithelzelle (2)
- Epitop (2)
- Epitope (2)
- Epitranscriptomics (2)
- Eplerenone (2)
- Epoxidation (2)
- Epoxidierung (2)
- Epstein-Barr-Virus (2)
- Erbrecht (2)
- Erdbeere (2)
- Erdbeobachtung (2)
- Erfahrungsverankerte Rezeption (2)
- Ergebnisse (2)
- Ergänzung (2)
- Erinnerung (2)
- Erk (2)
- Erlotinib (2)
- Erneuerbare-Energien-Gesetz (2)
- Ernteertrag (2)
- Ernährungstherapie (2)
- Ersatzstoff (2)
- Erwachsenenalter (2)
- Erysiphe graminis (2)
- Erythropoetin (2)
- Erythrozyten (2)
- Eschatologie (2)
- Eschatology (2)
- Escherichia coli K1 (2)
- Escitalopram (2)
- Eskalation (2)
- Essstörung (2)
- Esterasen (2)
- Estimation (2)
- Estrogen (2)
- Etacrynsäure (2)
- Ethernet (2)
- Ethnizität (2)
- Ethnographie (2)
- Ethnologie (2)
- Etrusker (2)
- EuGH (2)
- Eukaryoten (2)
- Euphronios (2)
- European Central Bank (2)
- European Organization for Nuclear Research. ATLAS Collaboration (2)
- Europäische Aktiengesellschaft (2)
- Europäische Integration (2)
- Europäisches Arzneibuch (2)
- Euthanasie (2)
- Event-related potentials (2)
- Everolimus (2)
- Evolutionspsychologie (2)
- Evolutionärer Algorithmus (2)
- Ewing-Sarkom (2)
- Exacerbation (2)
- Examensklausur (2)
- Exciton coupling (2)
- Exegese (2)
- Exekutive Funktionen (2)
- Exercise capacity (2)
- Exercise testing (2)
- Exomsequenzierung (2)
- Exosom <Vesikel> (2)
- Exotics (2)
- Expansion (2)
- Expansionsmikroskopie (2)
- Experiment (2)
- Experimental autoimmune encephalomyelitis (2)
- Experimental physics (2)
- Experteninterviews (2)
- Expertensystem (2)
- Expertise (2)
- Explainable AI (2)
- Explainable Artificial Intelligence (2)
- Explorative Datenanalyse (2)
- Explosion (2)
- Export (2)
- Expressionsanalyse (2)
- Extended Reality (2)
- Extensions of gauge sector (2)
- Extracellular Vesicles (2)
- Extracellular matrix (2)
- Extracorporeal Membrane Oxygenation (2)
- Extrakorporale Dialyse (2)
- Extrakorporale Membranoxygenierung (2)
- Extraversion (2)
- Extrazellulärmatrix (2)
- Extreme Value Theory (2)
- Extremereignisse (2)
- Extremwert (2)
- Exziton-Exziton-Annihilierung (2)
- Exzitotoxizität (2)
- Eye-Tracking (2)
- Eyelid (2)
- Ezetimib (2)
- F-actin (2)
- F8 fimbriae (2)
- FAAH (2)
- FAS (2)
- FCS (2)
- FDG PET/CT (2)
- FDG-PET/CT (2)
- FFPE (2)
- FGF-pathway (2)
- FGFR1 (2)
- FIB-4 (2)
- FKBP52 (2)
- FOSL1 (2)
- FRET sensors (2)
- FTIR spectroscopy (2)
- Fabry genotype (2)
- Fabry nephropathy (2)
- Fabry phenotype (2)
- Fachsprache (2)
- Factor receptor (2)
- Fagus sylvatica (2)
- Fahrertraining (2)
- Fahrradergometer (2)
- Falle (2)
- Fallsammlung (2)
- Familienuntersuchung (2)
- Family-Investigation (2)
- FarR (2)
- Farbensehen (2)
- Farbwahrnehmung (2)
- FasL (2)
- Faser (2)
- Fatty acids (2)
- Fbw7 (2)
- Fc-receptor (2)
- FcγR (2)
- Fear conditioning (2)
- Feedback (2)
- Fehlertoleranz (2)
- Fehlerverarbeitung (2)
- Fehlstellung (2)
- Feldforschung (2)
- Feldstärkemessung (2)
- Feldtheorie (2)
- Female (2)
- Femtochemistry (2)
- Fermentation (2)
- Fernsehmaske (2)
- Fernwartung (2)
- Ferroelektrikum (2)
- Ferromagnete (2)
- Ferromagnetikum (2)
- Ferromagnetische Halbleiter (2)
- Ferromagnetismus (2)
- Ferroptosis (2)
- Fersenbeinbruch (2)
- Festkörper (2)
- Festkörper-NMR (2)
- Fett (2)
- Fettgewebsstammzellen (2)
- Fettleibigkeit (2)
- Fettsäure (2)
- Fibromyalgia (2)
- Fibromyalgiesyndrom (2)
- Fibronectin (2)
- Ficaria calthifolia (2)
- Ficaria verna (2)
- Fieber (2)
- Field programmable gate array (2)
- Figur (2)
- Figurenrede (2)
- Fingerprint-Verfahren (2)
- Fingolimod (2)
- Finite-Volumen-Methode (2)
- Fish (2)
- Fixateur interne (2)
- Flagelle (2)
- Flagellen (2)
- Flagelline (2)
- Flash-Speicher (2)
- Flavonoids (2)
- Flexibilität (2)
- Fließeigenschaften (2)
- Flow cytometry (2)
- Fluconazol (2)
- Fluconazole (2)
- Fluency (2)
- Flugkörper (2)
- Flugzeitmassenspektrometrie (2)
- Fluid-Feststoff-System (2)
- Fluktuation (2)
- Fluorchinolone (2)
- Fluorescence in situ hybridization (2)
- Fluorescence microscopy (2)
- Fluoreszenzaktivierter Zellsortierer (2)
- Fluoreszenzlöschung (2)
- Fluoreszenzmarkierung (2)
- Fluoreszenzsonde (2)
- Fluoreszenzspektrometer (2)
- Fluorierung (2)
- Fluoxetine (2)
- Flussufer (2)
- Flächenbedarf (2)
- Flüchtlingskrise (2)
- Flüssiger Zustand (2)
- Flüssigkristalle (2)
- Foamy virus (2)
- Fokker-Planck-Gleichung (2)
- Fokker–Planck equation (2)
- Foldamere (2)
- Formaldehyd (2)
- Formation Flight (2)
- Formulation development (2)
- Forschungsparadigma (2)
- Fossil (2)
- FoxO3 (2)
- Fractalkin (2)
- Framework <Informatik> (2)
- Framework for Information Literacy for Higher Education (2)
- France (2)
- Frankfurter Allgemeine (2)
- Franz (2)
- Frauen (2)
- Freedom House (2)
- Freies Molekül (2)
- Freizügigkeit (2)
- Frequency (2)
- Frequency Domain (2)
- Frequenzanalyse (2)
- Freud (2)
- Friedreich-Ataxie (2)
- Front National (2)
- Frucht (2)
- Frustrated Lewis Pairs (2)
- Frustration (2)
- Frömmigkeit (2)
- Frühe akustisch evozierte Potentiale FAEP (2)
- Frühförderung (2)
- Frühjahr-Sommer-Encephalitis (2)
- Frühphase (2)
- Fullerenderivate (2)
- Fumonisine (2)
- Functional analyses (2)
- Fundoplikatio (2)
- Funktionelle Bildgebung (2)
- Funktionelle Kernspintomographie (2)
- Funktionelle Störung (2)
- Funktionentheorie (2)
- Funktionstest (2)
- Furan (2)
- Furanderivate (2)
- Furaneol (2)
- Furylborane (2)
- Fusion proteins (2)
- Future Internet (2)
- Fußballverein (2)
- Fähigkeit (2)
- Förderschule (2)
- Förderschwerpunkt geistige Entwicklung (2)
- Förster Resonance Energy Transfer (2)
- Förster Resonanz Energie Transfer (2)
- Führung (2)
- G Protein (2)
- G protein coupled receptor (2)
- G protein-coupled receptor (2)
- G-Protein-gekoppelte Rezeptoren (2)
- G-Protein-gekoppelter Rezeptor (2)
- G-protein coupled receptor (2)
- G-protein coupled receptors (2)
- G-protein-coupled receptor (2)
- G-quadruplexes (2)
- GABA-Rezeptor (2)
- GABAA receptors (2)
- GABP (2)
- GAD1 (2)
- GAD65 (2)
- GAP (2)
- GATA-3 (2)
- GEF (2)
- GERD (2)
- GIRK (2)
- GLAST (2)
- GLP-1 (2)
- GLT1 (2)
- GLUT1 (2)
- GLUT2 (2)
- GLV-1H68 (2)
- GLaD-Studie (2)
- GLaD-study (2)
- GMP (2)
- GPS (2)
- GRAPPA (2)
- GRP78 (2)
- GSK3 (2)
- GTP-bindende Proteine (2)
- GUT (2)
- GaMnAs (2)
- Gadolinium (2)
- Galaxienentwicklung (2)
- Galaxienhaufen (2)
- Galeruca tanaceti (2)
- Galle (2)
- Galliumantimonid (2)
- Galliumnitrid (2)
- Galois-Theorie (2)
- Galvanische Abscheidung (2)
- Gamet (2)
- Gametogenese (2)
- Gamma (2)
- Gamma-Konvergenz (2)
- Ganganalyse (2)
- Ganzkörperbestrahlung (2)
- Gas (2)
- Gas chromatography (2)
- Gastroschisis (2)
- Gastroösophageale Refluxkrankheit (2)
- Gastroösophagealer Reflux (2)
- Gastrulation (2)
- Gaumen (2)
- Gaumenplatte (2)
- Gaumenspalte (2)
- Gedächtnisentwicklung (2)
- Gedächtniszellen (2)
- Gefahrenabwehr (2)
- Gefitinib (2)
- Gefrierstrukturierung (2)
- Gefäßchirurgie (2)
- Gefäßverschluss (2)
- Gefäßwand (2)
- Gefüge (2)
- Gegenwartssprache (2)
- Geistiges Eigentum (2)
- Geld (2)
- Geldtheorie (2)
- Gelelektrophorese (2)
- Gelenkpositionierung (2)
- Gemeinnützigkeit (2)
- Gemeinschaftsunterkunft (2)
- Gemeinschaftsökologie (2)
- Gen BRCA 1 (2)
- Gender studies (2)
- Gene Regulation (2)
- Gene cloning (2)
- Gene duplication (2)
- Generalized Nash Equilibrium Problem (2)
- Genes (2)
- Genetic instability (2)
- Genetics research (2)
- Genitiv (2)
- Genklonierung (2)
- Genomik (2)
- Genomvariabilität (2)
- Gentechnologie (2)
- Geophysics (2)
- Geriatrics (2)
- Gerichtete Erstarrung (2)
- Gerichtshof (2)
- Geringverdiener (2)
- German Hepatitis C-Registry (2)
- German people (2)
- Germanistik (2)
- Geschichte 1100-1600 (2)
- Geschichte 1605-1687 (2)
- Geschichte 1900-2000 (2)
- Geschichte 1919-1945 (2)
- Geschichte 2014 (2)
- Geschichte der Zahnheilkunde (2)
- Geschlechtsdifferenzierung (2)
- Gesetzliche Krankenversicherung (2)
- Gestaltungsorientierte Bildungsforschung (2)
- Gesteinsbildung (2)
- Gesteinskunde (2)
- Gesundheit (2)
- Gewalttätigkeit (2)
- Geweberegeneration (2)
- Gewicht (2)
- Gewichtsabnahme (2)
- Gewürz (2)
- Glasfaserstift (2)
- Glatiramer acetate (2)
- Gleason score (2)
- Gleichberechtigung (2)
- Gleichverteilung (2)
- Gletscherschwankung (2)
- Gliederfüßer (2)
- Gliedergürtelmuskeldystrophie (2)
- Global Governance (2)
- Globale Optimierung (2)
- Globaler Süden (2)
- Glomeruli (2)
- Glucocorticoids (2)
- Glucose metabolism (2)
- Glucosetransporter (2)
- Gluino production (2)
- Glukokortikoide (2)
- Glutamate (2)
- Glycerin (2)
- Glycoengineering (2)
- Glykane (2)
- Glykolyse (2)
- Gold Nanoparticles (2)
- Golf von Akaba (2)
- Golgi apparatus (2)
- Golgi-Apparat (2)
- Gondwana (2)
- Gothenburg model (2)
- Gott <Motiv> (2)
- Graft-versus-leukemia (2)
- Gram-negative Bakterien (2)
- Granulieren (2)
- Granulit (2)
- Granulozyt (2)
- Gravitation (2)
- Grenze (2)
- Grenzwert (2)
- Grimmelshausen, Hans Jakob Christoffel von / Simplizissimus (2)
- Group B Streptococcus (2)
- Growth-differentiation Factor 15 (2)
- Großbritannien (2)
- Grundrechte (2)
- Grundstücksübertragung (2)
- Grundsubstanz (2)
- Grundvorstellung (2)
- Grundwortschatz (2)
- Guanidiniocarbonylpyrrol (2)
- Guanylylcyclase (2)
- Guidelines (2)
- Guillain-Barre-Syndrome (2)
- Guinea-pig uterus (2)
- Gyrasehemmer (2)
- H-1-NMR spectroscopy (2)
- H2O2 (2)
- HADS-D (2)
- HAE (2)
- HAND (2)
- HBV (2)
- HCM (2)
- HD (2)
- HDAC (2)
- HDBSCAN (2)
- HDGF (2)
- HEMT (2)
- HERV-K (2)
- HES (2)
- HFQ (2)
- HHV-6 (2)
- HIF-1 (2)
- HIF-1α (2)
- HIV-Demenz (2)
- HIV-Infection (2)
- HIV-infection (2)
- HIVDR (2)
- HKT transporter (2)
- HLA-E (2)
- HMG (2)
- HPA axis (2)
- HPK1 (2)
- HPLC-CD-Kopplung (2)
- HPP (2)
- HPV (2)
- HRQOL (2)
- HRXRD (2)
- HSC (2)
- HSM-sentence test (2)
- HSM-test (2)
- HT-29 (2)
- HaCaT (2)
- Habitat (2)
- Habitat fragmentation (2)
- Haemostasis (2)
- Haftvermittler (2)
- Halacha (2)
- Halbleiter-Supraleiter-Kontakt (2)
- Halbleitergrenzflächen (2)
- Halbmetall (2)
- Halcyon (2)
- Halictidae (2)
- Hallux (2)
- Halobacterium halobium (2)
- Halofuginon (2)
- Halothane (2)
- Hals-Nasen-Ohren-Heilkunde (2)
- Handelsimmobilie (2)
- Handlungsregulation (2)
- Hans Löffler (2)
- Haploidentical (2)
- Haplotyp (2)
- Hardware (2)
- Harnwegsinfekt (2)
- Harris Hip Score (2)
- Hashimoto-Thyreoiditis (2)
- Hausarzt (2)
- Hautleitfähigkeit (2)
- Hautlymphom (2)
- Hautstanzbiopsie (2)
- Hauttumor (2)
- Haßberge (2)
- Haßberge-Gebiet (2)
- HeLa-Zelle (2)
- Head orthosis therapy (2)
- Healthy subjects (2)
- Heart Failure (2)
- Heart rate variability (2)
- Hebamme (2)
- Heidelbeere (2)
- Helferzelle (2)
- Helicase (2)
- Helicobacter-pylori-Infektion (2)
- Helix-Coil-Transition (2)
- Helix-Knäuel-Umwandlung (2)
- Helkimo (2)
- Hellenistisch-jüdische Literatur (2)
- Helminths (2)
- Hemibodies (2)
- Hemmstoff (2)
- Hemmung (2)
- Hemolysin (2)
- Hemostasis (2)
- Hepatitis (2)
- Hepatitis-C-Virus (2)
- Hernia (2)
- Hernienchirurgie (2)
- Herpes (2)
- Herpes simplex (2)
- Herpesviren (2)
- Herzbildgebung (2)
- Herzdekompensation (2)
- Herzerkrankung (2)
- Herzfunktionsdiagnostik (2)
- Herzkrankheit (2)
- Herzneurose (2)
- Herzratenvariabilität (2)
- Hesse (2)
- Hessen (2)
- Heteroaromaten (2)
- Heterocycles (2)
- Heterogene Katalyse (2)
- Heterogenität (2)
- Heterologe Genexpression (2)
- Heterotope Ossifikation (2)
- Heterotransplantation (2)
- Hethitisch (2)
- Heuschrecken (2)
- Heusler (2)
- Heuslersche Legierung (2)
- Hexagonaler Kristall (2)
- Hexahydro-sila-difenidol analogues (2)
- Hidden-Markov-Modell (2)
- Hidradenitis suppurativa (2)
- Higgs-Teilchen (2)
- Hildegard <von Bingen> (2)
- Hilfsverb (2)
- Himmelskompass (2)
- Hippo pathway (2)
- Hippo signaling (2)
- Hippokampus (2)
- Hirnblutung (2)
- Hirndruck (2)
- Hirnmetastase (2)
- Hirnstammimplantat (2)
- Hispidulin (2)
- Histon-Methyltransferase (2)
- Historische Anthropologie (2)
- History (2)
- Hitzeschock (2)
- Hitzeschock Proteine (2)
- Hochaufgelöste Fluoreszenzmikroskopie (2)
- Hochauflösende Mikroskopie (2)
- Hochauflösung (2)
- Hochfrequenz (2)
- Hochfrequenz-Oszillations-Ventilation (2)
- Hochleistungslaser (2)
- Hochschulbildung (2)
- Hochschuldidaktik (2)
- Hochtemperatur (2)
- Hochwasser (2)
- Hodenhochstand (2)
- Hodgkin (2)
- Hohe Harmonische (2)
- Hohlfaserreaktor (2)
- Holocene (2)
- Holothuria spinifera (2)
- Homing (2)
- Homogener Raum (2)
- Homologe Rekombination (2)
- Homosexualität (2)
- Homöostase (2)
- Honey bee (2)
- Honorar (2)
- Hordeum vulgare (2)
- Hormon (2)
- Hospitalization (2)
- Hospiz (2)
- Host-parasite interaction (2)
- Host-parasite interactions (2)
- Host-pathogen interaction (2)
- Host-pathogen interactions (2)
- Huh6 (2)
- Human (2)
- Human behaviour (2)
- Human brain (2)
- Human papillomavirus (2)
- Human-Robot-Interaction (2)
- Humanserum (2)
- Humanstoffwechsel (2)
- Hunger (2)
- Hurwitz-Raum (2)
- HyMap (2)
- Hyaluronic Acid (2)
- Hyaluronic acid (2)
- Hybrid (2)
- Hybrid Polymer (2)
- Hybridvektor (2)
- Hydrocephalus (2)
- Hydrocortison (2)
- Hydrophosphinierung (2)
- Hydroxybutyrat <3-> (2)
- Hydroxycarbonsäuren (2)
- Hyperandrogenämie (2)
- Hyperbolische Differentialgleichung (2)
- Hypercholesterinämie (2)
- Hyperhidrose (2)
- Hyperkapnie (2)
- Hypertherme Chemotherapie (2)
- Hypertrophy (2)
- Hypopharynx (2)
- Hypopharynxkarzinom (2)
- Hypothermie (2)
- Hypothetical gauge bosons (2)
- Hysterie (2)
- Hämatopoetische Stammzellen (2)
- Hämochromatose (2)
- Hämoglobinaddukte (2)
- Hämolysin (2)
- Hämophilie (2)
- Härte (2)
- Häufigkeit (2)
- Höckerdeformation (2)
- Hörbahn (2)
- Hören (2)
- Hörgeräte (2)
- Hörsturz (2)
- Hörstörungen (2)
- Hüftdysplasie (2)
- Hüftendoprothese (2)
- Hüftgelenkarthrose (2)
- Hüftgelenksprothese (2)
- Hüftkopfnekrose (2)
- Hühnerembryo (2)
- I-tasser (2)
- IABP (2)
- IAP (2)
- IAPS (2)
- IAT (2)
- ICEP (2)
- ICF (2)
- IEEE 802.11 (2)
- IENFD (2)
- IFN-gamma (2)
- IFN-γ (2)
- II-VI semiconductor (2)
- II-VI-Halbleiter (2)
- II.> (2)
- IL-17 (2)
Institute
- Theodor-Boveri-Institut für Biowissenschaften (2244)
- Graduate School of Life Sciences (999)
- Physikalisches Institut (787)
- Institut für Anorganische Chemie (674)
- Medizinische Klinik und Poliklinik I (635)
- Institut für Psychologie (585)
- Institut für Organische Chemie (545)
- Medizinische Klinik und Poliklinik II (545)
- Neurologische Klinik und Poliklinik (501)
- Klinik und Poliklinik für Allgemein-, Viszeral-, Gefäß- und Kinderchirurgie (Chirurgische Klinik I) (500)
Schriftenreihe
- Cultural Animal Studies, Band 3 (24)
- Spezielle Didaktik der Sportarten (2)
- Aesthetische Eigenzeiten, 17 (1)
- Akten des ... Symposiums des Mediävistenverbandes; 13,2 (1)
- Alter Orient und Altes Testament : Sonderreihe Veröffentlichungen zur Kultur und Geschichte des Alten Orients ; 3 (1)
- Aventiuren; 13 (1)
- Berichte aus der Informatik (1)
- Deuterocanonical and Cognate Literature Studies (1)
- Deuterocanonical and Cognate Literature Yearbook (1)
- Epistemata. Reihe Literaturwissenschaft ; 483 (1)
- European Journal of Clinical Nutrition ; 70 (1)
- Forum Junge Romanistik 18 (1)
- Frontiers in Psychology (2023) 14:1219915. https://doi.org/10.3389/fpsyg.2023.1219915 (1)
- Frontiers in Public Health (2023) 11:1153088. https://doi.org/10.3389/fpubh.2023.1153088 (1)
- GenderCodes - Transkriptionen zwischen Wissen und Geschlecht; 17 (1)
- Grundzüge ; 45 (1)
- Image ; 185 (1)
- International Archives of the History of Ideas / Archives internationales d’histoire des idées 242 (1)
- Jahrbuch der Oswald-von-Wolkenstein-Gesellschaft; 17 (1)
- Journal of Neuroimaging; Volume 28 (1)
- Kaleidogramme ; 183 (1)
- Macht und Herrschaft; 15 (1)
- Methods in Molecular Biology 2533 (1)
- Methods in Molecular Biology; 2643 (1)
- Palingenesia; 112 (1)
- Philologica Germanica; 39 (1)
- Pirckheimer-Jahrbuch für Renaissance- und Humanismusforschung; 23 (1)
- Pirckheimer-Jahrbuch für Renaissance- und Humanismusforschung; 29 (1)
- Pluralisierung & Autorität; 27 (1)
- Redox Biology (2024) 70:103011. DOI: 10.1016/j.redox.2023.103011 (1)
- Schriften des Vereins für Reformationsgeschichte; 207 (1)
- Sozialwissenschaften heute ; 2 (1)
- Studien zur Literatur und Erkenntnis; 6 (1)
- Studien zur historisch-vergleichenden Sprachwissenschaft; 20 (1)
- Studien zur historischen Poetik; 23 (1)
- Trends in Medieval Philology; 5 (1)
- Universitätsforschungen zur Prähistorischen Archäologie ; 259 (1)
- Wirtschaftsrecht und Wirtschaftspolitik ; Bd. 207 (1)
- Wissenschaftliche Schriften der WWU Münster / Reihe XII ; 25 (1)
- Wolfenbütteler Forschungen ; 160 (1)
- Würzburger Geographische Manuskripte, Heft 88 (1)
- culturae ; 19 (1)
- spectrum Literaturwissenschaft / spectrum Literature; 22 (1)
Sonstige beteiligte Institutionen
- VolkswagenStiftung (24)
- Johns Hopkins School of Medicine (18)
- Fraunhofer-Institut für Silicatforschung ISC (8)
- IZKF Nachwuchsgruppe Geweberegeneration für muskuloskelettale Erkrankungen (7)
- Akademie der Wissenschaften und der Literatur, Mainz (6)
- DFG Forschungsgruppe 2757 / Lokale Selbstregelungen im Kontext schwacher Staatlichkeit in Antike und Moderne (LoSAM) (6)
- Clinical Trial Center (CTC) / Zentrale für Klinische Studien Würzburg (ZKSW) (5)
- Helmholtz Institute for RNA-based Infection Research (HIRI) (5)
- Johns Hopkins University School of Medicine (5)
- Universität Leipzig (5)
ResearcherID
- B-1911-2015 (1)
- B-4606-2017 (1)
- C-2593-2016 (1)
- D-1221-2009 (1)
- D-1250-2010 (1)
- D-3057-2014 (1)
- I-5818-2014 (1)
- J-8841-2015 (1)
- M-1240-2017 (1)
- N-2030-2015 (1)
Objectives. In diabetes accumulated advanced glycation end products (AGEs) are involved in the striking cardiovascular morbidity/mortality. We asked whether a hypovitaminosis D associates with an increased formation and toxicity of AGEs in diabetes.
Methods. In 276 diabetics (160M/116 F, age: 65.0 ± 13.4; 43 type 1,T1DM, and 233 type 2 patients, T2DM) and 121 nondiabetic controls (60 M/61 F; age: 58.6 ± 15.5 years) routine biochemistry, levels of 25-hydroxyvitamin D\(_{3}\) (25-(OH)D), skin autofluorescence (SAF), plasma AGE-associated fluorescence (AGE-FL), N\(^{ε}\) -(carboxymethyl) lysine (CML), soluble receptor for AGEs (sRAGE), soluble vascular adhesion protein-1 (sVAP-1), high sensitive C-reactive protein (hs-CRP), and renal function (eGFR) were determined.
Results. In the diabetics SAF and AGE-Fl were higher than those of the controls and correlated with age, duration of diabetes, and degree of renal impairment. In T2DM patients but not in T1DM the age-dependent rise of SAF directly correlated with hs-CRP and sVAP-1. 25-(OH)D levels in diabetics and nondiabetics were lowered to a similar degree averaging 22.5 ng/mL. No relationship between 25-(OH)D and studied markers except for sVAP-1 was observed in the diabetics. Conclusion. In diabetics hypovitaminosis D does not augment accumulation of AGEs and studied markers of microinflammation and oxidative stress except for sVAP-1.
Background and Objective
The aim of this single‐centre, two‐arm, parallel‐group, double‐blinded, randomised controlled trial was to investigate the disputed specific effectiveness of acupuncture by comparing acupuncture on specific and non‐specific points among patients with non‐chronic, painful TMDs.
Methods
Following predefined eligibility criteria, 49 consecutive patients of both sexes were recruited to the study. All subjects were diagnosed with a non‐chronic (Graded Chronic Pain Scale grade <3) painful TMD, as assessed using the Diagnostic Criteria for Temporomandibular Disorders (DC/TMD). Patients were randomly assigned to group A (acupuncture on specific points) or group B (acupuncture on non‐specific points) after the initial examination (T0). Both acupuncture treatment sessions were conducted by a trained dentist once a week for four weeks. The examination was repeated five weeks (T5) after T0 by one calibrated examiner who was unaware of the study groups. Characteristic pain intensity (CPI) was evaluated as the main outcome criterion and compared between times and treatment groups by means of non‐parametric tests (significance level set at P = .05). Secondary outcomes comprised the maximum corrected active mouth‐opening without pain (MAO); patients’ expectations regarding acupuncture treatment and pain development; depressivity; and oral health‐related quality of life (OHRQoL).
Results
A total of 41 patients (38 female) successfully completed the study (mean age: 40.17 ± 16.61). The two groups did not differ significantly at any time in terms of age and CPI. However, CPI was significantly (P < .05) lower at T5 than at T0 for both groups (29.66 and 30.35% lower in group A and group B, respectively). An increase in MAO was observed at T5 for both groups but was significant for group B only (P = .016). All patients had positive expectations of acupuncture therapy, and the two groups did not differ significantly at T5 with regard to the extent to which their expectations had been fulfilled by the treatment (P = .717). Comparison of T0 and T5 showed a statistically significant reduction of depressivity for group A (P = .0205), but no significant change for group B (P = .329). At T5, OHRQoL had improved significantly for both groups (group A, P = .018; group B, P < .001) compared with at T0.
Conclusions
Acupuncture on both specific and non‐specific points reduces the non‐dysfunctional pain of TMD patients. The effect of acupuncture on painful TMD cannot be attributed to the specific point selection.
Background
Differential RNA-sequencing (dRNA-seq) is indispensable for determination of primary transcriptomes. However, using dRNA-seq data to map transcriptional start sites (TSSs) and promoters genome-wide is a bioinformatics challenge. We performed dRNA-seq of Bradyrhizobium japonicum USDA 110, the nitrogen-fixing symbiont of soybean, and developed algorithms to map TSSs and promoters.
Results
A specialized machine learning procedure for TSS recognition allowed us to map 15,923 TSSs: 14,360 in free-living bacteria, 4329 in symbiosis with soybean and 2766 in both conditions. Further, we provide proteomic evidence for 4090 proteins, among them 107 proteins corresponding to new genes and 178 proteins with N-termini different from the existing annotation (72 and 109 of them with TSS support, respectively). Guided by proteomics evidence, previously identified TSSs and TSSs experimentally validated here, we assign a score threshold to flag 14 % of the mapped TSSs as a class of lower confidence. However, this class of lower confidence contains valid TSSs of low-abundant transcripts. Moreover, we developed a de novo algorithm to identify promoter motifs upstream of mapped TSSs, which is publicly available, and found motifs mainly used in symbiosis (similar to RpoN-dependent promoters) or under both conditions (similar to RpoD-dependent promoters). Mapped TSSs and putative promoters, proteomic evidence and updated gene annotation were combined into an annotation file.
Conclusions
The genome-wide TSS and promoter maps along with the extended genome annotation of B. japonicum represent a valuable resource for future systems biology studies and for detailed analyses of individual non-coding transcripts and ORFs. Our data will also provide new insights into bacterial gene regulation during the agriculturally important symbiosis between rhizobia and legumes.
Background
Postherpetic neuralgia (PHN) is the painful complication of a varicella zoster virus reactivation. We investigated the systemic and local gene expression of pro- and anti-inflammatory cytokine expression in patients with PHN.
Methods
Thirteen patients with PHN at the torso (Th4-S1) were recruited. Skin punch biopsies were obtained from the painful and the contralateral painless body area for intraepidermal nerve fiber density (IENFD) and cytokine profiling. Additionally, blood was withdrawn for systemic cytokine expression and compared to blood values of healthy controls. We analyzed the gene expression of selected pro- and anti-inflammatory cytokines (tumor necrosis factor-alpha [TNF] and interleukins [IL]-1β, IL-2, and IL-8).
Results
IENFD was lower in affected skin compared to unaffected skin (p<0.05), while local gene expression of pro- and anti-inflammatory cytokines did not differ except for two patients who had 7fold higher IL-6 and 10fold higher IL-10 gene expression in the affected skin compared to the contralateral unaffected skin sample. Also, the systemic expression of cytokines in patients with PHN and in healthy controls was similar.
Conclusion
While the systemic and local expression of the investigated pro- and anti-inflammatory cytokines was not different from controls, this may have been influenced by study limitations like the low number of patients and different disease durations. Furthermore, other cytokines or pain mediators need to be considered.
Interleukin-4 (IL-4) is an anti-inflammatory and analgesic cytokine that induces opioid receptor transcription. We investigated IL-4 knockout (ko) mice to characterize their pain behavior before and after chronic constriction injury (CCI) of the sciatic nerve as a model for neuropathic pain. We investigated opioid responsivity and measured cytokine and opioid receptor gene expression in the peripheral and central nervous system (PNS, CNS) of IL-4 ko mice in comparison with wildtype (wt) mice. Naïve IL-4 ko mice displayed tactile allodynia (wt: 0.45 g; ko: 0.18 g; p<0.001), while responses to heat and cold stimuli and to muscle pressure were not different. No compensatory changes in the gene expression of tumor necrosis factor-alpha (TNF), IL-1β, IL-10, and IL-13 were found in the PNS and CNS of naïve IL-4 ko mice. However, IL-1β gene expression was stronger in the sciatic nerve of IL-4 ko mice (p<0.001) 28 days after CCI and only IL-4 ko mice had elevated IL-10 gene expression (p = 0.014). Remarkably, CCI induced TNF (p<0.01), IL-1β (p<0.05), IL-10 (p<0.05), and IL-13 (p<0.001) gene expression exclusively in the ipsilateral spinal cord of IL-4 ko mice. The compensatory overexpression of the anti-inflammatory and analgesic cytokines IL-10 and IL-13 in the spinal cord of IL-4 ko mice may explain the lack of genotype differences for pain behavior after CCI. Additionally, CCI induced gene expression of μ, κ, and δ opioid receptors in the contralateral cortex and thalamus of IL-4 ko mice, paralleled by fast onset of morphine analgesia, but not in wt mice. We conclude that a lack of IL-4 leads to mechanical sensitivity; the compensatory hyperexpression of analgesic cytokines and opioid receptors after CCI, in turn, protects IL-4 ko mice from enhanced pain behavior after nerve lesion.
High-Dose Capsaicin for the Treatment of Neuropathic Pain: What We Know and What We Need to Know
(2014)
Neuropathic pain is a frequent and disabling condition with diverse underlying etiologies and is often difficult to treat. Systemic drug treatment is often limited in efficacy. Furthermore, adverse effects may be a limiting factor when trying to reach the necessary dose. Analgesics that can be applied topically have the potential to largely overcome this problem. They may be of particular advantage in localized neuropathic pain syndromes such as postherpetic neuralgia or small fiber neuropathy. Capsaicin, the pungent component of chili peppers, is a natural ligand of the transient receptor potential vanilloid 1 channel and has long been used as topically applicable cream with concentrations of 0.025 to 0.075%. In 2009, a high-concentration transdermal capsaicin 8% patch (Qutenza ; Acorda Therapeutics, Inc., Ardsley, NY, USA; Astellas Pharma Europe Ltd., Chertsey, Surrey, UK) was introduced for the treatment of peripheral neuropathic pain syndromes other than of diabetic origin in adults. It has since been widely used in diverse neuropathic pain disorders. In this review article, we summarize current knowledge on Qutenza, its advantages and problems, and expose unmet needs.
High-resolution ultrasonography (HRUS) is an emerging new tool in the investigation of peripheral nerves. We set out to assess the utility of HRUS performed at lower extremity nerves in peripheral neuropathies. Nerves of 26 patients with polyneuropathies of different etiologies and 26 controls were investigated using HRUS. Patients underwent clinical, laboratory, electrophysiological assessment, and a diagnostic sural nerve biopsy as part of the routine work-up. HRUS was performed at the sural, tibial, and the common, superficial, and deep peroneal nerves. The superficial peroneal nerve longitudinal diameter (LD) distinguished best between the groups: patients with immune-mediated neuropathies (n = 13, including six with histology-proven vasculitic neuropathy) had larger LD compared to patients with non-immune-mediated neuropathies (p < 0.05) and to controls (p < 0.001). Among all subgroups, patients with vasculitic neuropathy showed the largest superficial peroneal nerve LD (p < 0.001) and had a larger sural nerve cross-sectional area when compared with disease controls (p < 0.001). Enlargement of the superficial peroneal and sural nerves as detected by HRUS may be a useful additional finding in the differential diagnosis of vasculitic and other immune-mediated neuropathies.
Background
The X-chromosomally linked life-limiting Fabry disease (FD) is associated with deposits of the sphingolipid globotriaosylceramide 3 (Gb3) in various tissues. Skin is easily accessible and may be used as an additional diagnostic and follow-up medium. Our aims were to visualize skin Gb3 deposits in FD patients applying immunofluorescence and to determine if cutaneous Gb3 load correlates with disease severity.
Methods
At our Fabry Center for Interdisciplinary Therapy we enrolled 84 patients with FD and 27 healthy controls. All subjects underwent 5-mm skin punch biopsy at the lateral lower leg and the back. Skin samples were processed for immunohistochemistry using antibodies against CD77 (i.e. Gb3). Cutaneous Gb3 deposition was quantified in a blinded manner and correlated to clinical data.
Results
We found that Gb3 load was higher in distal skin of male FD patients compared to healthy controls (p<0.05). Men (p<0.01) and women (p<0.05) with a classic FD phenotype had higher distal skin Gb3 load than healthy controls. Men with advanced disease as reflected by impaired renal function, and men and women with small fiber neuropathy had more Gb3 deposits in distal skin samples than males with normal renal function (p<0.05) and without small fiber neuropathy. Gb3 deposits were not different between patients with and without enzyme replacement therapy.
Conclusions
Immunofluorescence on minimally invasive skin punch biopsies may be useful as a tool for assessment and follow-up in FD patients.
Objectives
The pathogenesis of fibromyalgia syndrome (FMS) is unclear. Transcranial ultrasonography revealed anechoic alteration of midbrain raphe in depression and anxiety disorders, suggesting affection of the central serotonergic system. Here, we assessed midbrain raphe echogenicity in FMS.
Methods
Sixty-six patients underwent transcranial sonography, of whom 53 were patients with FMS (27 women, 26 men), 13 patients with major depression and physical pain (all women), and 14 healthy controls (11 women, 3 men). Raphe echogenicity was graded visually as normal or hypoechogenic, and quantified by digitized image analysis, each by investigators blinded to the clinical diagnosis.
Results
Quantitative midbrain raphe echogenicity was lower in patients with FMS compared to healthy controls (p<0.05), but not different from that of patients with depression and accompanying physical pain. Pain and FMS symptom burden did not correlate with midbrain raphe echogenicity as well as the presence and severity of depressive symptoms.
Conclusion
We found reduced echogenicity of the midbrain raphe area in patients with FMS and in patients with depression and physical pain, independent of the presence or severity of pain, FMS, and depressive symptoms. Further exploration of this sonographic finding is necessary before this objective technique may enter diagnostic algorithms in FMS and depression.
Background
Fibromyalgia syndrome (FMS) is a chronic condition characterized by widespread pain and associated symptoms. We investigated cerebral activation in FMS patients by functional near-infrared spectroscopy (fNIRS).
Methods
Two stimulation paradigms were applied: a) painful pressure stimulation at the dorsal forearm; b) verbal fluency test (VFT). We prospectively recruited 25 FMS patients, ten patients with unipolar major depression (MD) without pain, and 35 healthy controls. All patients underwent neurological examination and all subjects were investigated with questionnaires (pain, depression, FMS, empathy).
Results
FMS patients had lower pressure pain thresholds than patients with MD and controls (p < 0.001) and reported higher pain intensity (p < 0.001). Upon unilateral pressure pain stimulation fNIRS recordings revealed increased bilateral cortical activation in FMS patients compared to controls (p < 0.05). FMS patients also displayed a stronger contralateral activity over the dorsolateral prefrontal cortex in direct comparison to patients with MD (p < 0.05). While all three groups performed equally well in the VFT, a frontal deficit in cortical activation was only found in patients with depression (p < 0.05). Performance and cortical activation correlated negatively in FMS patients (p < 0.05) and positively in patients with MD (p < 0.05).
Conclusion
Our data give further evidence for altered central nervous processing in patients with FMS and the distinction between FMS and MD.
Skin cytokine expression in patients with fibromyalgia syndrome is not different from controls
(2014)
Background
Fibromyalgia syndrome (FMS) is a chronic pain syndrome of unknown etiology. There is increasing evidence for small nerve fiber impairment in a subgroup of patients with FMS. We investigated whether skin cytokine and delta opioid receptor (DOR) gene expression in FMS patients differs from controls as one potential contributor to small nerve fiber sensitization.
Methods
We investigated skin punch biopsies of 25 FMS patients, ten patients with monopolar depression but no pain, and 35 healthy controls. Biopsies were obtained from the lateral upper thigh and lower calf. Gene expression of the pro-inflammatory cytokines tumor necrosis factor-alpha (TNF), interleukin (IL)-6, and IL-8 and of the anti-inflammatory cytokine IL-10 was analyzed using quantitative real-time PCR and normalizing data to 18sRNA as housekeeping gene. Additionally, we assessed DOR gene expression.
Results
All cytokines and DOR were detectable in skin samples of FMS patients, patients with depression, and healthy controls without intergroup difference. Also, gene expression was not different in skin of the upper and lower leg within and between the groups and in FMS patient subgroups.
Conclusions
Skin cytokine and DOR gene expression does not differ between patients with FMS and controls. Our results do not support a role of the investigated cytokines in sensitization of peripheral nerve fibers as a potential mechanism of small fiber pathology in FMS.
Background
Fabry disease is an inborn lysosomal storage disorder which is associated with small fiber neuropathy. We set out to investigate small fiber conduction in Fabry patients using pain-related evoked potentials (PREP).
Methods
In this case–control study we prospectively studied 76 consecutive Fabry patients for electrical small fiber conduction in correlation with small fiber function and morphology. Data were compared with healthy controls using non-parametric statistical tests. All patients underwent neurological examination and were investigated with pain and depression questionnaires. Small fiber function (quantitative sensory testing, QST), morphology (skin punch biopsy), and electrical conduction (PREP) were assessed and correlated. Patients were stratified for gender and disease severity as reflected by renal function.
Results
All Fabry patients (31 men, 45 women) had small fiber neuropathy. Men with Fabry disease showed impaired cold (p < 0.01) and warm perception (p < 0.05), while women did not differ from controls. Intraepidermal nerve fiber density (IENFD) was reduced at the lower leg (p < 0.001) and the back (p < 0.05) mainly of men with impaired renal function. When investigating A-delta fiber conduction with PREP, men but not women with Fabry disease had lower amplitudes upon stimulation at face (p < 0.01), hands (p < 0.05), and feet (p < 0.01) compared to controls. PREP amplitudes further decreased with advance in disease severity. PREP amplitudes and warm (p < 0.05) and cold detection thresholds (p < 0.01) at the feet correlated positively in male patients.
Conclusion
Small fiber conduction is impaired in men with Fabry disease and worsens with advanced disease severity. PREP are well-suited to measure A-delta fiber conduction.
A high load of white matter lesions and enlarged basilar arteries have been shown in selected patients with Fabry disease, a disorder associated with an increased stroke risk. We studied a large cohort of patients with Fabry disease to differentially investigate white matter lesion load and cerebral artery diameters. We retrospectively analyzed cranial magnetic resonance imaging scans of 87 consecutive Fabry patients, 20 patients with ischemic stroke, and 36 controls. We determined the white matter lesion load applying the Fazekas score on fluid-attenuated inversion recovery sequences and measured the diameters of cerebral arteries on 3D-reconstructions of the time-of-flight-MR-angiography scans. Data of different Fabry patient subgroups (males – females; normal – impaired renal function) were compared with data of patients with stroke and controls. A history of stroke or transient ischemic attacks was present in 4/30 males (13%) and 5/57 (9%) females with Fabry disease, all in the anterior circulation. Only one man with Fabry disease showed confluent cerebral white matter lesions in the Fazekas score assessment (1%). Male Fabry patients had a larger basilar artery (p<0.01) and posterior cerebral artery diameter (p<0.05) compared to male controls. This was independent of disease severity as measured by renal function and did not lead to changes in arterial blood flow properties. A basilar artery diameter of >3.2 mm distinguished between men with Fabry disease and controls (sensitivity: 87%, specificity: 86%, p<0.001), but not from stroke patients. Enlarged arterial diameters of the posterior circulation are present only in men with Fabry disease independent of disease severity.
Objective: We investigated cerebral opioid receptor binding potential in patients with fibromyalgia syndrome (FMS) using positron-emission-tomography (PET) and correlated our results with patients’ systemic interleukin-4 (IL-4) gene expression.
Methods: In this pilot study, seven FMS patients (1 man, 6 women) agreed to participate in experimental PET scans. All patients underwent neurological examination, were investigated with questionnaires for pain, depression, and FMS symptoms. Additionally, blood for IL-4 gene expression analysis was withdrawn at two time points with a median latency of 1.3 years. Patients were investigated in a PET scanner using the opioid receptor ligand F-18-fluoro-ethyl-diprenorphine ([18F]FEDPN) and results were compared with laboratory normative values.
Results: Neurological examination was normal in all FMS patients. Reduced opioid receptor binding was found in mid cingulate cortex compared to healthy controls (p < 0.005). Interestingly, three patients with high systemic IL-4 gene expression had increased opioid receptor binding in the fronto-basal cortex compared to those with low IL-4 gene expression (p < 0.005).
Conclusion: Our data give further evidence for a reduction in cortical opioid receptor availability in FMS patients as another potential central nervous system contributor to pain in FMS.
Fabry disease is an X-linked lysosomal storage disorder due to impaired activity of alpha-galactosidase A with intracellular accumulation of globotriaosylceramide. Associated small fiber pathology leads to characteristic pain in Fabry disease. We systematically assessed sensory system, physical activity, metabolic parameters, and morphology of male and female mice with alpha-galactosidase A deficiency (Fabry ko) from 2 to 27 months of age and compared results with those of age- and gender-matched wild-type littermates of C57Bl/6J background. Results From the age of two months, male and female Fabry mice showed mechanical hypersensitivity (p < 0.001 each) compared to wild-type littermates. Young Fabry ko mice of both genders were hypersensitive to heat stimulation (p < 0.01) and developed heat hyposensitivity with aging (p < 0.05), while cold hyposensitivity was present constantly in young (p < 0.01) and old (p < 0.05) Fabry ko mice compared to wild-type littermates. Stride angle increased only in male Fabry ko mice with aging (p < 0.01) in comparison to wild-type littermates. Except for young female mice, male (p < 0.05) and female (p < 0.01) Fabry ko mice had a higher body weight than wild-type littermates. Old male Fabry ko mice were physically less active than their wild-type littermates (p < 0.05), had lower chow intake (p < 0.001), and lost more weight (p < 0.001) in a one-week treadmill experiment than wild-type littermates. Also, Fabry ko mice showed spontaneous pain protective behavior and developed orofacial dysmorphism resembling patients with Fabry disease.
Conclusions. Mice with alpha-galactosidase A deficiency show age-dependent and distinct deficits of the sensory system. alpha-galactosidase A-deficient mice seem to model human Fabry disease and may be helpful when studying the pathophysiology of Fabry-associated pain.
The investigation of the Earth system and interplays between its components is of utmost importance to enhance the understanding of the impacts of global climate change on the Earth's land surface. In this context, Earth observation (EO) provides valuable long-term records covering an abundance of land surface variables and, thus, allowing for large-scale analyses to quantify and analyze land surface dynamics across various Earth system components. In view of this, the geographical entity of river basins was identified as particularly suitable for multivariate time series analyses of the land surface, as they naturally cover diverse spheres of the Earth. Many remote sensing missions with different characteristics are available to monitor and characterize the land surface. Yet, only a few spaceborne remote sensing missions enable the generation of spatio-temporally consistent time series with equidistant observations over large areas, such as the MODIS instrument.
In order to summarize available remote sensing-based analyses of land surface dynamics in large river basins, a detailed literature review of 287 studies was performed and several research gaps were identified. In this regard, it was found that studies rarely analyzed an entire river basin, but rather focused on study areas at subbasin or regional scale. In addition, it was found that transboundary river basins remained understudied and that studies largely focused on selected riparian countries. Moreover, the analysis of environmental change was generally conducted using a single EO-based land surface variable, whereas a joint exploration of multivariate land surface variables across spheres was found to be rarely performed.
To address these research gaps, a methodological framework enabling (1) the preprocessing and harmonization of multi-source time series as well as (2) the statistical analysis of a multivariate feature space was required. For development and testing of a methodological framework that is transferable in space and time, the transboundary river basins Indus, Ganges, Brahmaputra, and Meghna (IGBM) in South Asia were selected as study area, having a size equivalent to around eight times the size of Germany. These basins largely depend on water resources from monsoon rainfall and High Mountain Asia which holds the largest ice mass outside the polar regions. In total, over 1.1 billion people live in this region and in parts largely depend on these water resources which are indispensable for the world's largest connected irrigated croplands and further domestic needs as well. With highly heterogeneous geographical settings, these river basins allow for a detailed analysis of the interplays between multiple spheres, including the anthroposphere, biosphere, cryosphere, hydrosphere, lithosphere, and atmosphere.
In this thesis, land surface dynamics over the last two decades (December 2002 - November 2020) were analyzed using EO time series on vegetation condition, surface water area, and snow cover area being based on MODIS imagery, the DLR Global WaterPack and JRC Global Surface Water Layer, as well as the DLR Global SnowPack, respectively. These data were evaluated in combination with further climatic, hydrological, and anthropogenic variables to estimate their influence on the three EO land surface variables. The preprocessing and harmonization of the time series was conducted using the implemented framework. The resulting harmonized feature space was used to quantify and analyze land surface dynamics by means of several statistical time series analysis techniques which were integrated into the framework. In detail, these methods involved (1) the calculation of trends using the Mann-Kendall test in association with the Theil-Sen slope estimator, (2) the estimation of changes in phenological metrics using the Timesat tool, (3) the evaluation of driving variables using the causal discovery approach Peter and Clark Momentary Conditional Independence (PCMCI), and (4) additional correlation tests to analyze the human influence on vegetation condition and surface water area.
These analyses were performed at annual and seasonal temporal scale and for diverse spatial units, including grids, river basins and subbasins, land cover and land use classes, as well as elevation-dependent zones. The trend analyses of vegetation condition mostly revealed significant positive trends. Irrigated and rainfed croplands were found to contribute most to these trends. The trend magnitudes were particularly high in arid and semi-arid regions. Considering surface water area, significant positive trends were obtained at annual scale. At grid scale, regional and seasonal clusters with significant negative trends were found as well. Trends for snow cover area mostly remained stable at annual scale, but significant negative trends were observed in parts of the river basins during distinct seasons. Negative trends were also found for the elevation-dependent zones, particularly at high altitudes. Also, retreats in the seasonal duration of snow cover area were found in parts of the river basins. Furthermore, for the first time, the application of the causal discovery algorithm on a multivariate feature space at seasonal temporal scale revealed direct and indirect links between EO land surface variables and respective drivers. In general, vegetation was constrained by water availability, surface water area was largely influenced by river discharge and indirectly by precipitation, and snow cover area was largely controlled by precipitation and temperature with spatial and temporal variations. Additional analyses pointed towards positive human influences on increasing trends in vegetation greenness. The investigation of trends and interplays across spheres provided new and valuable insights into the past state and the evolution of the land surface as well as on relevant climatic and hydrological driving variables. Besides the investigated river basins in South Asia, these findings are of great value also for other river basins and geographical regions.
Breaking inversion symmetry in crystalline solids enables the formation of spin-polarized electronic states by spin-orbit coupling without the need for magnetism. A variety of interesting physical phenomena related to this effect have been intensively investigated in recent years, including the Rashba effect, topological insulators and Weyl semimetals. In this work, the interplay of inversion symmetry breaking and spin-orbit coupling and, in particular their general influence on the character of electronic states, i.e., on the spin and orbital degrees of freedom, is investigated experimentally. Two different types of suitable model systems are studied: two-dimensional surface states for which the Rashba effect arises from the inherently broken inversion symmetry at the surface, and a Weyl semimetal, for which inversion symmetry is broken in the three-dimensional crystal structure. Angle-resolved photoelectron spectroscopy provides momentum-resolved access to the spin polarization and the orbital composition of electronic states by means of photoelectron spin detection and dichroism with polarized light. The experimental results shown in this work are also complemented and supported by ab-initio density functional theory calculations and simple model considerations.
Altogether, it is shown that the breaking of inversion symmetry has a decisive influence on the Bloch wave function, namely, the formation of an orbital angular momentum. This mechanism is, in turn, of fundamental importance both for the physics of the surface Rashba effect and the topology of the Weyl semimetal TaAs.
Since the early days of Dirac flux quantization, magnetic monopoles have been sought after as a potential corollary of quantized electric charge. As opposed to magnetic monopoles embedded into the theory of electromagnetism, Weyl semimetals (WSM) exhibit Berry flux monopoles in reciprocal parameter space. As a function of crystal momentum, such monopoles locate at the crossing point of spin-polarized bands forming the Weyl cone. Here, we report momentum-resolved spectroscopic signatures of Berry flux monopoles in TaAs as a paradigmatic WSM. We carried out angle-resolved photoelectron spectroscopy at bulk-sensitive soft X-ray energies (SX-ARPES) combined with photoelectron spin detection and circular dichroism. The experiments reveal large spin- and orbital-angular-momentum (SAM and OAM) polarizations of the Weyl-fermion states, resulting from the broken crystalline inversion symmetry in TaAs. Supported by first-principles calculations, our measurements image signatures of a topologically non-trivial winding of the OAM at the Weyl nodes and unveil a chirality-dependent SAM of the Weyl bands. Our results provide directly bulk-sensitive spectroscopic support for the non-trivial band topology in the WSM TaAs, promising to have profound implications for the study of quantum-geometric effects in solids. Weyl semimetals exhibit Berry flux monopoles in momentum-space, but direct experimental evidence has remained elusive. Here, the authors reveal topologically non-trivial winding of the orbital-angular-momentum at the Weyl nodes and a chirality-dependent spin-angular-momentum of the Weyl bands, as a direct signature of the Berry flux monopoles in TaAs.
Background: To perform a systematic review and meta-analysis on cytokine levels in patients with fibromyalgia syndrome (FMS). Methods: Through December 2010 we systematically reviewed the databases PubMed, MEDLINE, and PsycINFO and screened the reference lists of 22 review articles for suitable original articles. Original articles investigating cytokines in patients with FMS were included. Data were extracted by two independent authors. Differences of the cytokine levels of FMS patients and controls were summarized by standardized mean differences (SMD) using a random effects model. Study quality was assessed applying methodological scores: modified Center of Evidence Based Medicine, Newcastle-Ottawa-Scale, and Würzburg Methodological Quality Score. Results: Twenty-five articles were included investigating 1255 FMS patients and 800 healthy controls. Data of 13/25 studies entered meta-analysis. The overall methodological quality of studies was low. The results of the majority of studies were not comparable because methods, investigated material, and investigated target cytokines differed. Systematic review of the selected 25 articles revealed that FMS patients had higher serum levels of interleukin (IL)-1 receptor antagonist, IL-6, and IL-8, and higher plasma levels of IL-8. Meta-analysis of eligible studies showed that FMS patients had higher plasma IL-6 levels compared to controls (SMD = -0.34 [-0.64, -0.03] 95% CI; p = 0.03). The majority of investigated cytokines were not different between patients and controls. Conclusions: The pathophysiological role of cytokines in FMS is still unclear. Studies of higher quality and with higher numbers of subjects are needed.
Das kolorektale Karzinom ist in der westlichen Welt die zweithäufigste Todesursache bei Männer und Frauen. Wichtige Pathomechanismen der kolorektalen Karzinome konnten in den letzten Jahren aufgedeckt werden. Die Anhäufung von genetischen Alterationen spielen sowohl bei sporadischen, als auch bei den hereditären Formen eine wichtige Rolle. Zwei molekulargenetische Hauptwege sind bei der kolorektalen Karzinogenese identifiziert worden: erstens der Tumorsuppressor-Pathway, bei dem es zu Alterationen in Tumorsuppresor- und Onkogenen kommt und zweitens der Mutatior-Pathway, der auf genetischen Alterationen in DNA-mismatch-Reparatur-Genen beruht, die zu einer genetischen Instabilität führen mit einer hohen Mutationsrate in repetitiven DNA-Sequenzen (sog. Mikrosatelliten). Es konnte gezeigt werden, dass oxidativer Stress, der durch die Bildung von H2O2 und anderen reaktiven Sauerstoffspezies (ROS) hervorgerufen wird, zur Entstehung von zellulären und DNA-Schäden wie z.B. oxidative Basenschäden, die ihrerseits u.a. die Entstehung von fixen Punktmutationen, Fragmentation der Desoxiribose und DNA-Strangbrüche initiieren, führen kann. Diese Veränderungen und auch die Mismatch-Reparatur-Defizienz begünstigen die Tumorprogression im Kolon. Es wird geschätzt, dass durch ROS täglich ca.20 000 hits pro Zelle verursacht werden. Es existieren sowohl extrazelluläre, als auch zelluläre antioxidative Abwhrsysteme, die Biomoleküle wie u.a. die DNA vor dem oxidativen Stress schützen. Unter diesen protektiven Enzymen gibt es neben der Superoxidismutase und der Katalase auch zahlreiche Selenoproteine, die Selenocystein in ihrem aktiven Zentrum tragen. Zu diesen Enzymen, die antioxidative Funktionen wahrnehmen gehören u.a. die Glutathionperoxidase, die Thioredoxinreduktase und das Selenoprotein P. Die Glutathionperoxidase-Familie besteht aus der cytosolischen Glutathioperoxidase (cGPx), der plasmatischen Glutathionperoxidase (pGPx), der gastrointestinalen Glutathionperoxidase (GI-GPx) und der Phospholipid-Hydroperoxid-Glutathionperoxidase (PH-GPx). Diese Enzymfamilie ist an der Reduktion von Hydroperoxiden beteiligt, wobei sie Glutathion als Cofaktor benutzt. Die Thioredoxinreduktase-Familie (TrxR-alpha und Trxr-beta) regeneriert oxidiertes Thioresoxin, das in die DNA-Synthese involviert ist und auch in zelluläre Redox-Regulationssysteme eingreift und Transkriptionsfaktoren beeinflusst. Das Selenoprotein P, das bis zu 10 Seleocysteinreste pro Molekül enthält, baut Peroxinitrit ab, das seinerseits ein starkes Agens bei der Nitrosylation von Biomolekülen ist. Zusätzlich reduziert Selenoprotein P auch Phospholipid-Hydroperoxide, wenn auch weniger effektiv als PH-GPx. Es konnte in Vorarbeiten gezeigt werden, dass Selenoproteine im Gastrointestinaltrakt eine differentielle Expression aufweisen. Kürzlich konnte in unserer Arbeitsgruppe die inverse mRNA-Expression selnocysteinhaltigen Proteine GI-GPx und Selenoprotein P in kolorektalen Adenomen im Vergleich zur Normalmukosa charakterisiert werden. Dabei zeigte sich eine dramatische Abnahme der Selenoprotein P-Expression, während die Expression der GI-GPx signifikant erhöht war. Im Rahmen der vorliegenden Arbeit untersuchten wir die Expression der GI-GPx in kolorektalen Karzinomen und Kolonkarzinom-Zelllinien, um auf Ebene der Selenoprotein-kodierenden Gene nach Alterationen zu suchen, die die veränderte Expression mit verursachen könnten.
In der vorliegenden Studie wurden QST, QSART, Hautbiopsien und Fragebögen
genutzt, um die Beteiligung kleiner Nervenfasern bei verschiedenen Formen der
Immunneuropathien zu untersuchen. Wir konnten hierbei eine signifikante
Beeinträchtigung der thermischen Reizleitung bei CIDP- und MADSAM-Patient/-innen
nachweisen sowie eine signifikant reduzierte Schweißproduktion am distalen
Unterschenkel bei MADSAM-Patient/-innen. Diese Ergebnisse belegen in allen drei
Untergruppen der immunvermittelten Neuropathien eine Beteiligung kleiner auch
unmyelinisierter Nervenfasertypen. MADSAM- und CIDP-Patient/-innen wiesen in der
QST ein ähnliches Schädigungsmuster auf. Dagegen unterschieden sie sich signifikant
in der QSART. Diese Ergebnisse können als weiterer Hinweis auf unterschiedliche
zugrundeliegende Pathomechanismen verstanden werden. MMN-Patient/-innen wiesen
insgesamt die geringste Small-Fiber-Beteiligung in den quantitativen Testungen auf.
Auch lagen bei MMN-Patient/-innen durchschnittlich die geringsten Schmerz-Scores und
autonomen Symptome vor. Es zeigten sich wenig signifikante Unterschiede zwischen
seropositiven und seronegativen Neuropathie-Patient/-innen. Diese jedoch bestätigten
unsere Hypothese einer etwas geringeren Small-Fiber-Beteiligung bei seropositiven
Patient/-innen. Bei der Vielzahl an unterschiedlichen Pathomechanismen innerhalb der
immunvermittelten Neuropathien erscheinen weitere Subklassifizierungen für eine
optimale Diagnosestellung und Therapie unabdingbar. Diese Arbeit konnte mit den oben
genannten Untersuchungen einen weiteren Beitrag zur Identifikation von klinischen und
quantitativen Unterschieden innerhalb dieser großen Erkrankungsgruppe leisten.
Künftige, größere Studien dieser Art können möglicherweise hier nur als Tendenzen
gesehene Erkenntnisse belegen und sollten durch zusätzliche Informationen wie
Korrelation zu Krankheitsdauer, Therapie, Laborchemie und elektrophysiologischen
Untersuchen weitere interessante Erkenntnisse liefern.
Introduction/Aims
Schwann cell clusters have been described at the murine dermis-epidermis border. We quantified dermal Schwann cells in the skin of patients with small-fiber neuropathy (SFN) compared with healthy controls to correlate with the clinical phenotype.
Methods
Skin punch biopsies from the lower legs of 28 patients with SFN (11 men, 17 women; median age, 54 [range, 19-73] years) and 9 healthy controls (five men, four women, median age, 34 [range, 25-69] years) were immunoreacted for S100 calcium-binding protein B as a Schwann cell marker, protein-gene product 9.5 as a pan-neuronal marker, and CD207 as a Langerhans cell marker. Intraepidermal nerve fiber density (IENFD) and subepidermal Schwann cell counts were determined.
Results
Skin samples of patients with SFN showed lower IENFD (P < .05), fewer Schwann cells per millimeter (P < .01), and fewer Schwann cell clusters per millimeter (P < .05) than controls. When comparing SFN patients with reduced (n = 13; median age, 53 [range, 19-73] years) and normal distal (n = 15, median age, 54 [range, 43-68] years) IENFD, the number of solitary Schwann cells per millimeter (p < .01) and subepidermal nerve fibers associated with Schwann cell branches (P < .05) were lower in patients with reduced IENFD. All three parameters correlated positively with distal IENFD (P < .05 to P < .01), whereas no correlation was found between Schwann cell counts and clinical pain characteristics.
Discussion
Our data raise questions about the mechanisms underlying the interdependence of dermal Schwann cells and skin innervation in SFN. The temporal course and functional impact of Schwann cell presence and kinetics need further investigation.
Unter Ausnutzung der Reaktivität von Borylanionen wurden neuartige Übergangsmetallboridokomplexe synthetisiert, bei denen ein "nacktes" Boratom als Ligand für bis zu vier Übergangsmetalle vorliegt. Strukturelle und bindungstheoretische Eigenschaften der Boridokomplexe wurden mit gängigen metallorganischen Analysemethoden sowie mit DFT-Methoden untersucht. Dabei zeigte sich, dass die erhaltenen Tetrametalloboridokomplexe eine planare Koordinationsgeometrie um das Borzentrum aufweisen und damit ein Äquivalent zu anti van't Hoff/Le Bel-Verbindungen des Kohlenstoffs darstellen.
Synthese und Relevanz von Oxylipinen in Blättern, Wurzeln und Samen von \(Arabidopsis\) \(thaliana\)
(2016)
Die Lipidoxidation kann sowohl enzymatisch als auch nicht enzymatisch erfolgen. Der erste Schritt der enzymatischen Oxidation wird durch Lipoxygenasen katalysiert, von welchen es in Arabidopsis thaliana sechs verschiedene Isoformen gibt. Dabei werden die Lipoxygenasen nach dem Kohlenstoffatom klassifiziert, welches sie oxidieren. Somit gehören die LOX1 und LOX5 zu den 9-Lipoxygenasen, während LOX2, LOX3, LOX4 und LOX6 zu den 13 Lipoxygenasen zählen. Während der Samenalterung findet vermehrt eine Lipidperoxidation statt, welche mit einem Verfall des Samens sowie einer verringerten Keimrate korreliert. Im Rahmen dieser Arbeit wurde zunächst erfolgreich ein System zur künstlichen Samenalterung von Arabidopsis thaliana etabliert. Bei der künstlichen Alterung stiegen ähnlich wie bei der natürlichen Samenalterung oxidierte Lipide an und die Keimrate fiel ab. Nach Alterung konnte ein Anstieg von sechs verschiedenen oxidierten Triacylglycerolen detektiert werden. Es konnte in dieser Arbeit mit Hilfe von Mutanten mit Defekten in mehreren der Lipoxygenase Gene gezeigt werden, dass die Oxidation dieser veresterten Fettsäuren zum größten Teil nicht enzymatisch erfolgt. Bei der Alterung stiegen zudem enzymatisch gebildete 9 Lipoxygenase Produkte wie freie Hydroxy- und Ketofettsäuren an. Bei einer Analyse der freien oxidierten Fettsäuren konnte ebenfalls mit Lipoxygenase Mutanten ermittelt werden, dass diese hauptsächlich via LOX1 oxidiert werden. Die Untersuchung der Keimraten der Lipoxygenase Mutanten nach Alterung zeigte in mehreren Versuchen eine leicht erhöhte Keimrate der lox1 im Vergleich zum Wildtyp. Eine exogene Behandlung von Wildtyp Samen mit verschiedenen 9-Lipoxygenase Produkten, welche bei der Alterung ansteigen, führte allerdings nicht zu einer Keimungshemmung. Somit scheinen Produkte wie Hydroxy- und Ketofettsäuren der 9-Lipoxygenase LOX1 nicht die Hauptursache für die Keimungshemmung nach Alterung zu sein.
Darüber hinaus konnte in dieser Arbeit gezeigt werden, dass eine Behandlung der Blüten des Wildtyps mit Methyljasmonat zu einer signifikant höheren Keimrate der Samen im Vergleich zu Samen von unbehandelten Pflanzen nach Alterung führt. Ein „Lipidprofiling“ der Samen von mit Methyljasmonat behandelten Pflanzen wies signifikant geringere Gehalte sowohl an freien als auch veresterten oxidierten Fettsäuren auf, was mit einer erhöhten Lebensfähigkeit korrelierte. Diese Erkenntnisse könnten von großer Relevanz für die Landwirtschaft sein, falls eine Übertragung auf Nutzpflanzen möglich ist.
Ein weiterer Schwerpunkt dieser Arbeit war eine eingehende Untersuchung der Rolle und Funktion der LOX6. Mit Hilfe von GUS Färbungen konnte eine Lokalisation der LOX6 in Blättern und Wurzeln nachgewiesen werden.
Zudem wurde ein 35SLOX6GFP Konstrukt erstellt und in Arabidopsis thaliana Pflanzen stabil transformiert. Mit den selektionierten Linien könnte in Zukunft auch die intrazelluläre Lokalisation der LOX6 untersucht werden. Außerdem wurden Konstrukte mit dem Reportergen GFP und AOS sowie LOX2 hinter dem 35S Promotor kloniert, welche ebenfalls für weitere Lokalisations- und Kolokalisationsstudien genutzt werden können. Zudem wurde mit der Klonierung eines Konstruktes begonnen, um in Zukunft einen spezifischen LOX6 Antikörper herstellen und auch die endogene LOX6 Lokalisation in dem Wildtyp analysieren zu können. Um die Produkte der LOX6 zu untersuchen, wurden 35SLOX6 Linien sowie die lox6 Mutante verwendet. Obwohl Hydroxyfettsäuren und Jasmonate Folgeprodukte der LOX6 sind, wiesen die 35SLOX6 Linien weder basal, noch nach Stress erhöhte Gehalte dieser im Vergleich zum Wildtyp auf. Somit geben die 35SLOX6 Linien einen Hinweis darauf, dass LOX6 im Wildtyp nicht limitierend für die Produktion von Hydroxyfettsäuren und Jasmonaten sein könnte. Um zu untersuchen, ob das Substrat der LOX6 der limitierende Faktor sein könnte, wurde eine Behandlung mit α Linolensäure durchgeführt. Dabei entstanden allerdings nicht mehr Folgeprodukte der LOX6, sondern es fand sowohl in den 35SLOX6 Linien als auch in dem Wildtyp eine massive nicht enzymatische radikalische Oxidation der Fettsäuren statt. Um festzustellen, ob sich durch eine LOX6 Überexpression das Metabolom ändert, wurde eine „untargeted Analyse“ mit 35SLOX6 Linien durchgeführt. Diese zeigte vier Metabolite, welche in den 35SLOX6 Linien im Vergleich zum Wildtyp unterschiedlich stark vorhanden waren. Zudem sollte untersucht werden, ob sich die Physiologie und Stressresistenz in den Überexpressionslinien im Vergleich zum Wildtyp unterscheiden. Dabei zeichneten sich die 35SLOX6 Linien durch kleinere, hellere und rundere Blätter aus. Zudem wurden die Wurzeln der 35SLOX6 Linien bei Fraßversuchen mit Pocellio scaber im Vergleich zum Wildtyp weniger bevorzugt gefressen. Diese Erkenntnisse sowie die generierten Konstrukte und Pflanzenlinien können in der Zukunft einen weiteren Einblick in die vielfältigen Funktionen und Produkte der LOX6 gewähren.
Background: There is extensive evidence that explicit memory, which involves conscious recall of encoded information, can be modulated by emotions; emotions may influence encoding, consolidation or retrieval of information. However, less is known about the modulatory effects of emotions on procedural processes like motor memory, which do not depend upon conscious recall and are instead demonstrated through changes in behaviour. Experiment 1: The goal of the first experiment was to examine the influence of emotions on motor learning. Four groups of subjects completed a motor learning task performing brisk isometric abductions with their thumb. While performing the motor task, the subjects heard emotional sounds varying in arousal and valence: (1) valence negative / arousal low (V-/A-), (2) valence negative / arousal high (V-/A+), (3) valence positive / arousal low (V+/A-), and (4) valence positive / arousal high (V+/A+). Descriptive analysis of the complete data set showed best performances for motor learning in the V-/A- condition, but the differences between the conditions did not reach significance. Results suggest that the interaction between valence and arousal may modulate motor encoding processes. Since limitations of the study cannot be ruled out, future studies with different emotional stimuli have to test the assumption that exposure to low arousing negative stimuli during encoding has a facilitating effect on short term motor memory. Experiment 2: The purpose of the second experiment was to investigate the effects of emotional interference on consolidation of sequential learning. In different sessions, 6 groups of subjects were initially trained on a serial reaction time task (SRTT). To modulate consolidation of the newly learned skill, subjects were exposed, after the training, to 1 of 3 (positive, negative or neutral) different classes of emotional stimuli which consisted of a set of emotional pictures combined with congruent emotional musical pieces or neutral sound. Emotional intervention for each subject group was done in 2 different time intervals (either directly after the training session, or 6 h later). After a 72 h post-training interval, each group was retested on the SRTT. Re-test performance was evaluated in terms of response times and accuracy during performance of the target sequence. Emotional intervention did not influence either response times or accuracy of re-testing SRTT task performance. However, explicit awareness of sequence knowledge was enhanced by arousing negative stimuli applied at 0 h after training. These findings suggest that consolidation of explicit aspects of procedural learning may be more responsive toward emotional interference than are implicit aspects. Consolidation of different domains of skill acquisition may be governed by different mechanisms. Since skill performance did not correlate with explicit awareness we suggest that implicit and explicit modes of SRTT performance are not complementary. Experiment 3: The aim of the third experiment was to analyze if the left hemisphere preferentially controls flexion responses towards positive stimuli, while the right hemisphere is specialized towards extensor responses to negative pictures. To this end, right-handed subjects had to pull or push a joystick subsequent to seeing a positive or a negative stimulus in their left or right hemifield. Flexion responses were faster for positive stimuli, while negative stimuli were associated with faster extensions responses. Overall, performance was fastest when emotional stimuli were presented to the left visual hemifield. This right hemisphere superiority was especially clear for negative stimuli, while reaction times towards positive pictures showed no hemispheric difference. We did not find any interaction between hemifield and response type. Neither was there a triple interaction between valence, hemifield and response type. In our experimental context the interaction between valence and hemifield seems to be stronger than the interaction between valence and motor behaviour. From these results we suppose that under certain conditions a hierarchy scaling of the asymmetry patterns prevails, which might mask any other existing asymmetries.
Das Synaptonemalkomplexprotein SYCP1 ist eine Strukturkomponente des Synaptonemalkomplexes (SC) von Saeugern, einer meiosespezifischen Struktur, die wesentlich fuer die Synapse, Rekombination und Segregation homologer Chromosomen ist. Der SC besteht aus zwei lateralen Elementen (LEs) und einer zentralen Region (CR), in deren Mitte das zentrale Element (CE) liegt. Dabei sind die LEs den Achsen der homologen Chromosomen aufgelagert und werden in der CR durch Transversalfilamente (TFs) mit dem CE verbunden. Im Protein SYCP1 (125 kDa) flankieren zwei nicht-helikale terminale Domaenen eine ausgedehnte zentrale „Coiled-Coil“-Domaene. Fuer diese Domaene wird angenommen, dass sie die die Kluft zwischen LEs und CE ueberbrueckt, wobei die C-Termini in den LEs verankert sind und die N-Termini im CE lokalisiert wurden. Um die molekulare Architektur des SC besser zu verstehen und die Bedeutung von SYCP1 für die Zusammenlagerung des SC aufzudecken, wurden die Polymerisationseigenschaften von SYCP1 erforscht. Dazu wurde das Protein in somatischen Zellen exprimiert. In diesem experimentellem Ansatz polymerisierte SYCP1 autonom zu filamentoesen Strukturen, welche sich auf ultrastruktureller Ebene als alternierende elektronendichte Balken offenbarten, die ueber TFs verbunden waren. Dieser Aufbau glich parallel aneinander gereihten Stapeln von SCs, so genannten Polykomplexen (PCs). Die Analyse der Orientierung der SYCP1 Molekuele innerhalb der PCs erwies, dass diese hochorganisiert vorliegen und die Organisation von SYCP1 innerhalb von PCs und SCs identisch ist. Folglich kann sich SYCP1 sogar in Abwesenheit anderer SC-Proteine zu Strukturen zusammenlagern, die der CR entsprechen und muss dementsprechend beim Aufbau der CR des SC den grundlegenden Faktor darstellen. Für eine genauere Analyse wurden ausgewaehlte Mutanten von SYCP1 exprimiert. Moleküle mit modifizierter Laenge der zentralen alpha-helikalen Domaene resultierten in der Bildung von PCs mit veränderter Weite der CR. Dies beweist, dass die „Coiled-Coil“-Domaene den Abstand der CR eines PC bestimmt und impliziert dieselbe Funktion in der SC-Bildung. Darueber hinaus wurde gezeigt, dass SYCP1 Molekuele mit Deletion des nicht-helikalen N-Terminus immer noch in der Lage sind, PCs zu bilden, diese Eigenschaft aber stark eingeschraenkt ist. Das bezeugt die Bedeutung des N-Terminus sowohl in der PC-Bildung als auch im Aufbau des CE von SCs, weist aber dabei auch dem vorderen Teil der „Coiled-Coil“-Domaene eine wichtige Rolle zu. Im Gegensatz dazu war bei Mutanten mit Deletion des nicht-helikalen C-Terminus die PC-Bildung vollstaendig blockiert, was auf eine große Bedeutung dieser Domaene fuer die Polymerisation hinweist. Ein weiterer Hauptgegenstand der Arbeit war die Charakterisierung von Bindungspartnern von SYCP1. Über Immungoldlokalisation auf Maushoden konnten die Proteine Syce1 und Cesc1 als erste ausschliessliche Komponenten des CE des SC bestimmt werden. Zusaetzlich wurde die Interaktion dieser Proteine mit dem N-Terminus von SYCP1 verifiziert. SYCP1 bildet also die Grundstruktur des CE aus und rekrutiert Syce1 und Cesc1.
In der vorliegenden Arbeit wird die Darstellung einer Reihe monoarylsubstituierter Bisdimethylamino-1-bromo-2-arlydiborane(4) beschrieben. Sowohl die Umsetzung der monoarylsubstituierten Ligandenvorstufen mit einem weiteren Äquivalent Lithium- oder Natriumaryl in einem Ether/Toluol-Gemisch als auch die Umsetzung von 1,2-Dibrom-bis(dimethylamino)diboran(4) mit einem mehrfachen Überschuss Lithium- oder Natriumaryl führte zur Bildung von diarylsubstituierten Diboranen(4). Umsetzung der Ligandenvorstufen mit Lithiumorganylen, wie beispielsweise Li[CH3] oder Li[C4H9] führt zu doppelt deprotonierten Verbindungen. Werden die dilithiierten Verbindungen mit Metallhalogeniden der Gruppe 4 in einem Toluol/Ether-Gemisch umgesetzt, können [2]Borametallocenophane erhalten werden. Von einigen der Verbindungen konnte die Struktur im Festkörper mittels Einkristallstrukturanalyse bestimmt werden. Die Verbindungen zeigen in Lösung ein dynamisches Gleichgewicht, welches durch die Flexibilität der B-B-Brücke ermöglicht wird. Dieses konnte mittels NMR Spektroskopie untersucht werden. Auch die Reaktivität der Verbindungen wurde erforscht. Versuche zur oxidativen Addition von Platin(0) in die B-B-Bindung, wie sie bereits für ähnliche Systeme beschrieben waren, scheiterten. Ebenfalls nicht erfolgreich war der versuchte Austausch der Dimethylaminogruppen an den Bor-Atomen. Di(fluorenyl)substituierte [2]Borametallocenophane zeigen in der Reihe der dargestellten Verbindungen ein einzigartiges Verhalten. Wird die dilithiierte Liganden-Vorstufe bei der Umsetzung mit den Metallhalogeniden der Gruppe 4 Licht ausgesetzt, so lagert sie zum 1,3-Diboretan um. Auch oxidativ kann diese Umlagerung ausgelöst werden. Das Umlagerungsprodukt war von anderen Reaktionen bereits bekannt, konnte im Rahmen dieser Arbeit aber erstmals strukturell charakterisiert werden. Die Dichloroverbindungen der [2]Borametallocenophane können mittels Li[CH3] in die entsprechenden Dimethylkomplexe überführt werden. Damit besteht die Möglichkeit, die Verbindungen nicht nur mit MAO, sondern auch mit alternativen Co-Katalysatoren, wie beispielsweise Tris-(pentafluorphenyl)boran für die Olefinpolymerisation zu aktivieren. Die Aktivierung mittels MAO wurde sowohl mittels NMR- als auch mittels UV/Vis-Spektroskopie bei verschiedenen [Al]/[Zr] Verhältnissen untersucht. Neben den [2]Borametallocenonphanen konnte mit Verbindung [(n5-C29H37)2ZrCl2] das erste Metallocen mit dem neuen OctafluH-Liganden und zwei koordinierenden Arylgruppen dargestellt werden. Um die Polymerisationseigenschaften der Verbindungen zu untersuchen, wurde ein neuer Versuchsaufbau entworfen. Zur Überwachung der Polymerisationen wurde ein Programm entwickelt, was in der Lage war, verbrauchte Gasmenge und Temperatur im Reaktoraufzuzeichnen. Hier wurden die katalytischen Eigenschaften einer Serie von [2]Borametallocenophanen und des dargestellten Metallocens [(n5-C29H37)2ZrCl2] in der Ethen-Homopolymerisation untersucht. Diese Polymere wurden mittels DSC auf ihre thermischen Eigenschaften hin geprüft. Ausgewählte Polymere wurden in Zusammenarbeit mit der LyondellBasell Industries, Basell Polyolefine GmbH, Frankfurt mittels GPC auf ihr mittleres Molekulargewicht und dessen Verteilung hin untersucht. Alle Daten wurden mit denen von industriell verwendeten Katalysatoren und den von Kraft bekannten [1]Borametallocenophanen verglichen. In weiteren Untersuchungen wurde überprüft, in wie weit die Polymerisationsbedingungen, wie beispielsweise das [Al]/[Zr]-Verhältnis, die Temperatur oder der Druck Auswirkungen auf die Eigenschaften des Polymers haben. Eine Reihe von Komplexen wurde überdies in der Ethen/[1]Hexen-Copolymerisation untersucht. Die erhaltenen Copolymere wurden mittels DSC-, GPC-, IR- und NMR- Spektroskopie analysiert. Zusammenfassend lässt sich feststellen, dass eine Reihe neuer Verbindungen dargestellt und charakterisiert werden konnte, wobei insbesondere der neuartige Ligand OctafluH (C29H38) eingesetzt wurde. Die dargestellten [2]Borametallocenophane sind aktive Katalysatoren in der Ziegler-Natta ähnlichen Olefinpolymerisation. Die dargestellten Polymere wurden mittels verschiedener Methoden untersucht. Es zeigte sich, dass [2]Borametallocenophane langkettige Polyolefine und Ethen/1-Hexen Copolymere liefern können.
When More Is Better – Consumption Priming Decreases Responders’ Rejections in the Ultimatum Game
(2017)
During the past decades, economic theories of rational choice have been exposed to outcomes that were severe challenges to their claim of universal validity. For example, traditional theories cannot account for refusals to cooperate if cooperation would result in higher payoffs. A prominent illustration are responders’ rejections of positive but unequal payoffs in the Ultimatum Game. To accommodate this anomaly in a rational framework one needs to assume both a preference for higher payoffs and a preference for equal payoffs. The current set of studies shows that the relative weight of these preference components depends on external conditions and that consumption priming may decrease responders’ rejections of unequal payoffs. Specifically, we demonstrate that increasing the accessibility of consumption-related information accentuates the preference for higher payoffs. Furthermore, consumption priming increased responders’ reaction times for unequal payoffs which suggests an increased conflict between both preference components. While these results may also be integrated into existing social preference models, we try to identify some basic psychological processes underlying economic decision making. Going beyond the Ultimatum Game, we propose that a distinction between comparative and deductive evaluations may provide a more general framework to account for various anomalies in behavioral economics.
Utility is perhaps the most central concept in modern economic theorizing. However, the behaviorist reduction to Revealed Preference not only removed the psychological content of utility but experimental investigations also exposed numerous anomalies in this theory.
This program of research focused on the psychological processes by which utility judgments are generated. For this purpose, the standard assumption of a homogeneous concept is substituted by the Utilitarian Duality Hypothesis.
In particular, judgments concerning categorical utility (uCat) infer an object's category based on its attributes which may subsequently allow the transfer of evaluative information like feelings or attitudes. In contrast, comparative utility (uCom) depends on the distance to a reference value on a specific dimension of comparison. Importantly, dimensions of comparison are manifold and context dependent.
In a series of experiments, we show that the resulting Dual Utility Model is able to explain several known anomalies in a parsimonious fashion. Moreover, we identify central factors determining the relative weight assigned to both utility components.
Finally, we discuss the implications of the Utilitarian Duality for both, the experimental practice in economics as well as the consequences for economic theorizing. In sum, we propose that the Dual Utility Model can serve as an integrative framework for both the rational model and its anomalies.
Das kürzlich publizierte MTUS1-Gen zeigt Eigenschaften eines Tumorsuppressor-Gens. So liegt die MTUS1-Expression in verschiedenen Tumorzelllinien vermindert vor und bei rekombinanter Expression in der schnell wachsenden Pankreaskarzinomzelllinie MiaPaCa-2 konnte die Proliferation signifikant reduziert werden. Darüber hinaus interagiert MTUS1 mit dem AT2-Rezeptor und scheint durch die Inhibierung des RTK-Signalwegs die Zellproliferation zu regulieren. Nach den Untersuchungen der MiaPaCa-2-Zelllinie konnte eine Mutation in der Exonsequenz und der vorhergesagten Promotorregion als Ursache der niedrigen MTUS1-Expression ausgeschlossen werden. Die Analyse des Promotorbereichs hinsichtlich des Methylierungsmusters der CpG- und CpNpG-Inseln brachte deutliche Methylierungsunterschiede in den CpNpG-Inseln der MiaPaCa-2-Zellen gegenüber HUVEC-Zellen zu Tage. Die anschließende Untersuchung der vorhergesagten Promotorregion mit Hilfe eines Promotor-Assays brachte die Gewissheit, dass es sich bei der untersuchten Sequenz um einen Transkription regulierenden Genabschnitt handelt. Durch die Transfektion von HUVEC-Zellen mit MTUS1-siRNA konnten nachweislich Zellen mit einem funktionellen MTUS1-Knockout hergestellt werden. Diese Zellen zeigten mit der verminderten MTUS1-Expression ein signifikant erhöhtes Wachstum. Die Ergebnisse der Zellversuche legen die Vermutung nahe, dass MTUS1 deshalb als Tumorsuppressor-Gen agieren kann, weil es die Zellproliferation reguliert und so der funktionelle MTUS1-Knockout mit einem erhöhten Zellwachstum einhergeht. Als Mechanismus der Geninaktivierung kommt die Hypomethylierung der vorhergesagten Promotorsequenz in Frage. Die Untersuchung der Colontumorgewebe und Normalgewebe von zehn Patienten mit Colonkarzinom zeigte eine deutliche Reduktion der MTUS1-Protein-Expression in 50% der Tumorgewebe. Bei diesen Patienten konnte ebenfalls eine signifikant reduzierte mRNA-Expression nachgewiesen werden. Wie bereits bei den MiaPaCa-2-Zellen nachgewiesen, zeigte sich eine Hypomethylierung der CpNpG-Inseln in den Geweben mit geringer MTUS1-Expression. Diese veränderte Methylierung könnte die Erklärung für die verminderte Transkription des MTUS1-Gens sein. Mit dem MTUS1-Knockout-Maus-Modell wurde die Grundlage für das bessere Verständnis der Funktion von MTUS1 in vivo geschaffen. Nach erfolgreicher Blastozysteninjektion und Zucht der homozygoten Knockout-Mäuse, konnte auf DNA-, mRNA- und Protein-Ebene die geglückte Ausschaltung des MTUS1-Gens bestätigt werden. Bei der Langzeituntersuchung der Tiere zeigten sich vor allem Abweichungen im Blutbild, wonach die homozygoten und heterozygoten Tiere auffallend hohe Werte an Leukozyten und Lymphozyten aufwiesen. Durch die pathologische Untersuchung konnte eine extramedulläre Hämatopoese und lymphatische Infiltrate in verschiedenen Organen nachgewiesen werden und gaben Hinweise auf eine Bluterkrankung. Nach diesen pathologischen Ergebnissen zeigten 23% der homozygoten und 17% der heterozygoten Tiere Symptome eines B-Zell-Lymphoms. Bei den Wildtyp-Tieren konnten keine pathologischen Auffälligkeiten gezeigt werden. Fast ein Viertel der homozygoten Mäuse wiesen eine Herzhypertrophie auf, oft einhergehend mit einer chronischen Glomerulonephritis und einer Atelektase der Lunge. Eine denkbare Erklärung für die blutdruckunabhängige Entstehung der Herzhypertrophie wäre eine Beeinflussung von Wachstumsfaktoren, da bereits nachgewiesen wurde, dass eine durch MTUS1 vermittelte Inhibierung von Insulin-, bFGF- und EGF-gesteuerten Signalkaskaden eine Inaktivierung von ERK2 zur Folge hatte. Mit Hilfe einer X-Gal-Färbung von verschiedenen Organen einer Wildtyp-, heterozygoten und homozygoten Maus konnten Erkenntnisse über die Genaktivität von MTUS1 in den verschiedenen Organen gewonnen werden. Zusammenfassend lässt sich von einer hohen MTUS1-Expression in den meisten Epithelzellen und Endothelzellen sprechen, außerdem weisen die Kardiomyozyten im Herz und die Purkinjefasern im Gehirn eine hohe Expression auf. Bei der Untersuchung von homozygoten und Wildtyp-Bauchhautfibroblasten wurde schließlich eine geringere Zellgröße der homozygoten Fibroblasten festgestellt. Mit der X-Gal-Färbung konnte nachgewiesen werden, dass das MTUS1-Protein vorwiegend in der Nähe des Zellkerns lokalisiert ist. Eine der untersuchten homozygoten Fibroblastenlinien zeigte gegenüber den anderen Fibroblasten eine deutlich erhöhte Proliferation. Das könnte ein Hinweis auf eine antiproliferative Wirkung von MTUS1 und eine Erklärung für die kleinere Zellgröße der homozygoten Fibroblasten sein. Als Zusammenfassung aller hier gezeigten Ergebnisse konnte die Hypothese untermauert werden, dass es sich bei MTUS1 um ein Tumorsuppressor-Gen handelt, das seine antiproliferativen Eigenschaften wahrscheinlich in Kooperation mit dem AT2-Rezeptor durch die Inhibierung des RTK-Signalwegs vermittelt.
Es gibt viele Hinweise, dass G-Protein-gekoppelte Rezeptoren bei ihrer Aktivierung durch einen Agonisten ligandenselektive Konformationen eingehen. Ein tatsächlichen Beleg hierfür konnte bisher in lebenden Zellen noch nicht erbracht werden. Zu diesem Zweck wurde in dieser Arbeit ein Fluoreszenz-Resonanz-Energie-Transfer (FRET)-basierter Ansatz gewählt, um ligandenselektive Konformationen in der dritten intrazellulären Schleife des α2a-adrenergen Rezeptors (α2a-AR) in lebenden Zellen darzustellen. Dazu wurden Rezeptorsensoren erstellt, welche jeweils ein CFP am Ende des C-Terminus trugen und in der dritten intrazellulären Schleife an verschiedenen Stellen mit einem Tetracysteinmotiv versehen wurden. Drei Konstrukte wurden verglichen, die das Tetracysteinmotiv N-terminal in der Nähe der Transmembrandomäne V (I3-N), in der Mitte der dritten intrazellulären Schleife (I3-M) beziehungsweise C-terminal in der Nähe der Transmembrandomäne VI (I3-C) trugen. Die drei Rezeptorsensoren unterschieden sich hinsichtlich ihrer Ligandenbindung sowie ihrer G-Proteinaktivierung nicht vom Wildtyp α2a-AR. Durch das Tetracysteinmotiv ist es möglich, den Rezeptor spezifisch mit dem niedermolekularen Fluorophor FlAsH (fluorescein arsenical hairpin binder) zu markieren, welcher als Akzeptor für den Donor CFP in FRET-Experimenten dient. Die Änderung des FRET-Signals zwischen den beiden Fluorophoren, das durch den vollen Agonist Norepinephrin ausgelöst wurde, war bei allen drei Rezeptorsensoren vergleichbar. Der starke partielle Agonist Clonidin war ebenfalls in der Lage, in allen drei Konstrukten ein ähnliches FRET-Signal hervorzurufen. Dagegen zeigte der partielle Agonist Dopamin an dem Konstrukt I3-N ein signifikant schwächeres Signal, als an I3-C. Die schwachen partiellen Agonisten Octopamin und Norphenephrin konnten an den Konstrukten I3-N und I3-M keine Änderung des FRET-Signals bewirken, wobei an I3-C eine deutliche Signaländerung detektiert wurde. Dies legt nahe, dass die Transmembrandomäne V bei der Aktivierung des Rezeptors eine kleinere Bewegung eingeht als die Transmembrandomäne VI, und bestätigt damit ein auf Röntgenstrukturanlysen basierendes Modell der Rezeptorbewegung. Außerdem wurden die Aktivierungskinetiken für die Agonisten Norepinephrin und Dopamin verglichen. Hierbei konnte gezeigt werden, dass die durch Norepinephrin ausgelöste Bewegung an allen beobachteten Punkten gleich schnell war. Im Gegensatz dazu aktivierte Dopamin I3-C und I3-M ca. 1,5-mal langsamer, als Norepinephrin. Für das I3-N Konstrukt wurde sogar eine 3-mal langsamere Aktivierung gemessen. Diese Daten zeigen, dass unterschiedliche Agonisten in der dritten intrazellulären Schleife spezifische Konformationen auslösen können. Die Untersuchungen zur Rezeptorbewegung im ersten Teil dieser Arbeit wurde mit dem kleinen Fluorophor FlAsH in Kombination mit einer großen GFP-Variante durchgeführt. Im zweiten Teil dieser Arbeit wurde eine Methode entwickelt, bei der es möglich ist Proteine spezifisch mit beiden kleinen Fluorophoren FlAsH und ReAsH in einer lebenden Zelle zu markieren. Hierfür wurden zwei Tetracysteinmotive, CCPGCC und FLNCCPGCCMEP, gewählt, an die beide kleine Fluorophore kovalent binden. Durch Verdrängungsexperimente mit BAL konnte gezeigt werden, dass FlAsH für beide Motive eine dreifach höhere Affinität besitzt, als ReAsH. Dabei besitzt das FLNCCPGCCMEP-Motiv jedoch eine dreifach höhere Affinität zu dem jeweiligen Fluorophor besitzt als CCPGCC. Durch Ausnutzung dieser Affinitätsunterschiede konnte ein Protokoll entwickelt werden, mit dem es möglich ist, beide Motive in einer Zelle zu markieren. Dabei werden zunächst beide Motive mit ReAsH markiert. Durch anschließendes Waschen mit einer geeigneten Konzentration von BAL wird das ReAsH ausschließlich von der CCPGCC-Sequenz verdrängt, wohingegen die FLNCCPGCCMEP-Sequenz mit ReAsH markiert bleibt. Die nun unbesetzte CCPGCC-Sequenz kann dann anschließend mit FlAsH markiert werden, ohne dabei die Bindung des ReAsH an die FLNCCPGCCMEP-Sequenz zu beeinflussen. Um die Funktionalität dieses Protokolls zu überprüfen, sollten zwei verschiedene Proteine mit unterschiedlicher subzellulärer Lokalisation in einer lebenden Zelle spezifisch mit jeweils einem kleinen Fluorophor markiert werden. Hierzu wurden ein PTH-Rezeptor, in dem im C-Terminus die FLNCCPGCCMEP-Sequenz eingebracht wurde, mit ReAsH und ein β-Arrestin-2, dem die CCPGCC-Sequenz eingebracht wurde, in Zellen co-exprimiert und gemäß dem Protokoll mit FlAsH und ReAsH markiert. Beide Proteine konnten spezifisch markiert werden, wobei der mit ReAsH markierte PTH-Rezeptor eine deutliche Lokalisation in der Zellmembran zeigte. Durch sequentielle Exzitation konnte in der gleichen Zelle das zytosolisch lokalisierte, mit FlAsH markierte β-Arrestin-2 detektiert werden. Wurden die so markierten Zellen mir 1 µM PTH stimuliert, wurde das FlAsH-markierte β-Arrestin-2 an die Zellmembran rekrutiert. Somit konnte durch die Entwicklung dieses Protokolls eine duale spezifische Markierung von Proteinen mit zwei kleinen Fluorophoren zu innerhalb einer Zelle erreicht werden.
Anästhetika-induzierte Präkonditionierung (APC) mit Desfluran vermittelt einen endogenen Schutzmechanismus gegen den Ischämie/Reperfusionsschaden im Tiermodell mit männlichen C57BL/6 Mäusen. Die Calcium-Calmodulinkinase IIδ (CamKIIδ) spielt eine zentrale Rolle im intrazellulären Calciumhaushalt und beim Ischämie/Reperfusionsschaden.
Ein Ergebnis dieser Studie zeigt, dass eine Desfluran-vermittelte Reduktion der Herzinfarktgröße in Wildtyptieren, nicht aber in Mäusen mit homozygotem genetischen Knock-Out (KO) der CaMKIIδ stattfindet. Weiterhin wird gezeigt, dass der CaMKIIδ KO die Expression von Phospholamban (PLB) und die Phosphorylierung von PLB an der Aminosäurestelle Serin 16 im Vergleich zum Wildtyp mehr als verdoppelt, ermittelt via Western-Immunoblotting. Darüber hinaus wird gezeigt, dass die Expression des β1 –Adrenorezeptors (AR) in Tieren mit homo- und heterozygotem CaMKIIδ KO im Vergleich zum Wildtyp signifikant erhöht ist. APC mit Desfluran hebt diese erhöhte β1 –AR Konzentrationen im homozygoten, aber nicht im heterozygoten KO auf. Dies zeigt, dass sich die β1 –AR Expression entsprechend der CaMKIIδ Verfügbarkeit adaptiert, dieser Effekt aber durch APC unterbunden werden kann.
Untersuchungen zum elastisch-plastischen Verhalten von Kristalloberflächen mittels Kraft-Eindringtiefen-Verfahren Die ‘registrierende Härteprüfung‘ nach dem Kraft-Eindringtiefen-Verfahren hat in den letzten Jahren mehr und mehr an Bedeutung gewonnen, um mechanische Materialparameter vor allem dünner Filme und beschichteter Oberflächen im Nanometermaßstab zu messen. Das kontrollierte Eindringen einer Meßspitze in eine Oberfläche mit definierter Kraft bei gleichzeitiger Registrierung der zurückgelegten Wegstrecke ermöglicht die Aufzeichnung sogenannter Kraft-Weg-Kurven. Deren Auswertung liefert quantitative Daten der mechanischen Materialeigenschaften wie Härte (H), Elastizitätsmodul (E), Bruchfestigkeit oder Kriechanteil. Im Laufe eines pharmazeutischen Herstellungsprozesses müssen fast alle eingesetzten Wirk- und Hilfsstoffe zerkleinert werden. Die dabei geforderten Feinheitsgrade lassen sich oft nur durch den Einsatz effizienter Maschinen, wie zum Beispiel der Luftstrahlmühlen erreichen. Dieser energie- und kostenaufwendige Zerkleinerungsprozeß ist bis heute noch nicht vollständig kontrollierbar. Das makroskopische Verhalten von partikulären Schüttgütern, wie etwa deren Bruchfestigkeit, benötigte Bruchkraft oder -energie, wird weitgehend von den elastisch-plastischen Materialeigenschaften mitbestimmt. Demnach sollten Härte und Elastizität einen entscheidenden Einfluß darauf haben, ob und in welchem Ausmaß ein Partikelkollektiv zerkleinert wird. Die Eindruckexperimente wurden an vier verschiedenen, handelsüblichen, kristallinen Schüttgütern durchgeführt (CaCO3, Natriumascorbat, NaCl, Saccharose). Dabei konnte gezeigt werden, daß sich die einzelnen Proben z.T. erheblich in ihren mechanischen Eigenschaften unterscheiden. Alle untersuchten Materialien sind durch ausgeprägtes elastoplastisches Verhalten charakterisiert. Während der elastische Anteil an der Gesamtverformung für Calcit, Natriumascorbat und Saccharose etwa 30% beträgt, zeigt Natriumchlorid nahezu vollständig plastische Deformation. Die elastische Rückfederung in der Entlastungsphase liegt für Kochsalz jeweils unter 10%. Ebenso schwanken die gemessenen Härtewerte der pharmazeutischen Schüttgüter in einem Bereich von 0,4GPa und 3,0GPa. Dabei erweist sich das Calciumcarbonat als härtestes und sehr sprödes Material (H»3,0GPa und E»85GPa). Im Gegensatz dazu ist das Natriumchlorid sehr weich und leicht plastisch verformbar (H»0,5GPa und E»42GPa). Weiterhin kann der bei einer Vielzahl von kristallinen Materialien nachgewiesene ‘indentation size effect’, also die Abhängigkeit der Härte von der Eindruckgröße, bestätigt werden. Bei geringen Eindringtiefen ist die Härte signifikant erhöht, wogegen sie mit zunehmender Indenttiefe auf konstante Werte absinkt. Die Energiezufuhr in Form einer äußeren mechanischen Beanspruchung beeinflußt ebenfalls die Härte. Art und Ausmaß der Beanspruchung spielen dabei die entscheidende Rolle. Partikel, welche in einer Luftstrahlmühle zerkleinert wurden, zeigen im Vergleich zu unbeanspruchten Teilchen signifikant höhere Werte. Der Grund für diesen Härtezuwachs liegt in der Kaltverfestigung des Materials. Die hohe Prallenergie und in deren Folge die Veränderung der partikulären Mikrostruktur führen vor allem bei kleinen, stark beanspruchten Partikeln zu einer gesteigerten Härte. Die elastisch-plastischen Parameter sind eng mit der Kristallstruktur und der Orientierung der Atome im Kristallgitter verknüpft. Jedoch kann eine Anisotropie bezüglich der mechanischen Kennwerte für die kristallinen Materialien nicht bestätigt werden. Eindruckexperimente unter wechselnden Rotationswinkeln ergaben keine statistisch unterscheidbaren Meßwerte.
The importance of proactive and timely prediction of critical events is steadily increasing, whether in the manufacturing industry or in private life. In the past, machines in the manufacturing industry were often maintained based on a regular schedule or threshold violations, which is no longer competitive as it causes unnecessary costs and downtime. In contrast, the predictions of critical events in everyday life are often much more concealed and hardly noticeable to the private individual, unless the critical event occurs. For instance, our electricity provider has to ensure that we, as end users, are always supplied with sufficient electricity, or our favorite streaming service has to guarantee that we can watch our favorite series without interruptions. For this purpose, they have to constantly analyze what the current situation is, how it will develop in the near future, and how they have to react in order to cope with future conditions without causing power outages or video stalling.
In order to analyze the performance of a system, monitoring mechanisms are often integrated to observe characteristics that describe the workload and the state of the system and its environment. Reactive systems typically employ thresholds, utility functions, or models to determine the current state of the system. However, such reactive systems cannot proactively estimate future events, but only as they occur. In the case of critical events, reactive determination of the current system state is futile, whereas a proactive system could have predicted this event in advance and enabled timely countermeasures. To achieve proactivity, the system requires estimates of future system states. Given the gap between design time and runtime, it is typically not possible to use expert knowledge to a priori model all situations a system might encounter at runtime. Therefore, prediction methods must be integrated into the system. Depending on the available monitoring data and the complexity of the prediction task, either time series forecasting in combination with thresholding or more sophisticated machine and deep learning models have to be trained.
Although numerous forecasting methods have been proposed in the literature, these methods have their advantages and disadvantages depending on the characteristics of the time series under consideration. Therefore, expert knowledge is required to decide which forecasting method to choose. However, since the time series observed at runtime cannot be known at design time, such expert knowledge cannot be implemented in the system. In addition to selecting an appropriate forecasting method, several time series preprocessing steps are required to achieve satisfactory forecasting accuracy. In the literature, this preprocessing is often done manually, which is not practical for autonomous computing systems, such as Self-Aware Computing Systems. Several approaches have also been presented in the literature for predicting critical events based on multivariate monitoring data using machine and deep learning. However, these approaches are typically highly domain-specific, such as financial failures, bearing failures, or product failures. Therefore, they require in-depth expert knowledge. For this reason, these approaches cannot be fully automated and are not transferable to other use cases. Thus, the literature lacks generalizable end-to-end workflows for modeling, detecting, and predicting failures that require only little expert knowledge.
To overcome these shortcomings, this thesis presents a system model for meta-self-aware prediction of critical events based on the LRA-M loop of Self-Aware Computing Systems. Building upon this system model, this thesis provides six further contributions to critical event prediction. While the first two contributions address critical event prediction based on univariate data via time series forecasting, the three subsequent contributions address critical event prediction for multivariate monitoring data using machine and deep learning algorithms. Finally, the last contribution addresses the update procedure of the system model. Specifically, the seven main contributions of this thesis can be summarized as follows:
First, we present a system model for meta self-aware prediction of critical events. To handle both univariate and multivariate monitoring data, it offers univariate time series forecasting for use cases where a single observed variable is representative of the state of the system, and machine learning algorithms combined with various preprocessing techniques for use cases where a large number of variables are observed to characterize the system’s state. However, the two different modeling alternatives are not disjoint, as univariate time series forecasts can also be included to estimate future monitoring data as additional input to the machine learning models. Finally, a feedback loop is incorporated to monitor the achieved prediction quality and trigger model updates.
We propose a novel hybrid time series forecasting method for univariate, seasonal time series, called Telescope. To this end, Telescope automatically preprocesses the time series, performs a kind of divide-and-conquer technique to split the time series into multiple components, and derives additional categorical information. It then forecasts the components and categorical information separately using a specific state-of-the-art method for each component. Finally, Telescope recombines the individual predictions. As Telescope performs both preprocessing and forecasting automatically, it represents a complete end-to-end approach to univariate seasonal time series forecasting. Experimental results show that Telescope achieves enhanced forecast accuracy, more reliable forecasts, and a substantial speedup. Furthermore, we apply Telescope to the scenario of predicting critical events for virtual machine auto-scaling. Here, results show that Telescope considerably reduces the average response time and significantly reduces the number of service level objective violations.
For the automatic selection of a suitable forecasting method, we introduce two frameworks for recommending forecasting methods. The first framework extracts various time series characteristics to learn the relationship between them and forecast accuracy. In contrast, the other framework divides the historical observations into internal training and validation parts to estimate the most appropriate forecasting method. Moreover, this framework also includes time series preprocessing steps. Comparisons between the proposed forecasting method recommendation frameworks and the individual state-of-the-art forecasting methods and the state-of-the-art forecasting method recommendation approach show that the proposed frameworks considerably improve the forecast accuracy.
With regard to multivariate monitoring data, we first present an end-to-end workflow to detect critical events in technical systems in the form of anomalous machine states. The end-to-end design includes raw data processing, phase segmentation, data resampling, feature extraction, and machine tool anomaly detection. In addition, the workflow does not rely on profound domain knowledge or specific monitoring variables, but merely assumes standard machine monitoring data. We evaluate the end-to-end workflow using data from a real CNC machine. The results indicate that conventional frequency analysis does not detect the critical machine conditions well, while our workflow detects the critical events very well with an F1-score of almost 91%.
To predict critical events rather than merely detecting them, we compare different modeling alternatives for critical event prediction in the use case of time-to-failure prediction of hard disk drives. Given that failure records are typically significantly less frequent than instances representing the normal state, we employ different oversampling strategies. Next, we compare the prediction quality of binary class modeling with downscaled multi-class modeling. Furthermore, we integrate univariate time series forecasting into the feature generation process to estimate future monitoring data. Finally, we model the time-to-failure using not only classification models but also regression models. The results suggest that multi-class modeling provides the overall best prediction quality with respect to practical requirements. In addition, we prove that forecasting the features of the prediction model significantly improves the critical event prediction quality.
We propose an end-to-end workflow for predicting critical events of industrial machines. Again, this approach does not rely on expert knowledge except for the definition of monitoring data, and therefore represents a generalizable workflow for predicting critical events of industrial machines. The workflow includes feature extraction, feature handling, target class mapping, and model learning with integrated hyperparameter tuning via a grid-search technique. Drawing on the result of the previous contribution, the workflow models the time-to-failure prediction in terms of multiple classes, where we compare different labeling strategies for multi-class classification. The evaluation using real-world production data of an industrial press demonstrates that the workflow is capable of predicting six different time-to-failure windows with a macro F1-score of 90%. When scaling the time-to-failure classes down to a binary prediction of critical events, the F1-score increases to above 98%.
Finally, we present four update triggers to assess when critical event prediction models should be re-trained during on-line application. Such re-training is required, for instance, due to concept drift. The update triggers introduced in this thesis take into account the elapsed time since the last update, the prediction quality achieved on the current test data, and the prediction quality achieved on the preceding test data. We compare the different update strategies with each other and with the static baseline model. The results demonstrate the necessity of model updates during on-line application and suggest that the update triggers that consider both the prediction quality of the current and preceding test data achieve the best trade-off between prediction quality and number of updates required.
We are convinced that the contributions of this thesis constitute significant impulses for the academic research community as well as for practitioners. First of all, to the best of our knowledge, we are the first to propose a fully automated, end-to-end, hybrid, component-based forecasting method for seasonal time series that also includes time series preprocessing. Due to the combination of reliably high forecast accuracy and reliably low time-to-result, it offers many new opportunities in applications requiring accurate forecasts within a fixed time period in order to take timely countermeasures. In addition, the promising results of the forecasting method recommendation systems provide new opportunities to enhance forecasting performance for all types of time series, not just seasonal ones. Furthermore, we are the first to expose the deficiencies of the prior state-of-the-art forecasting method recommendation system.
Concerning the contributions to critical event prediction based on multivariate monitoring data, we have already collaborated closely with industrial partners, which supports the practical relevance of the contributions of this thesis. The automated end-to-end design of the proposed workflows that do not demand profound domain or expert knowledge represents a milestone in bridging the gap between academic theory and industrial application. Finally, the workflow for predicting critical events in industrial machines is currently being operationalized in a real production system, underscoring the practical impact of this thesis.
In dieser experimentellen Studie wurde der Einfluss einer moderaten Hypothermie nach Induktion einer epiduralen, extraaxialen Raumforderung auf das neurologische Outcome, auf histopathologische Veränderungen und mittels bildgebender Methoden untersucht. Der Hauptaugenmerk wurde dabei eindeutig auf die neurologischen Verlaufsuntersuchungen mit Hilfe einer neuropsychologischen Testbatterie gelegt.Damit konnte in etwa die Hauptphase der klinischen Rekonvaleszens nach Trauma abgedeckt werden.Zudem hatten die meisten experimentellen Arbeiten bereits nach wesentlich kürzeren Zeiträumen ihre Nachuntersuchungen abgeschlossen.Die Gesamtmortalität betrug bei den normotherm behandelten Tieren 55% und bei den hypotherm behandelten Tieren 45%. Der Unterschied betrug damit nur 10% und war nicht signifikant. Betrachtet man aber die Mortalitätsraten differenzierter, so zeigt sich bezüglich der rein schädigungsbedingten Mortalität als Folge von schweren neurologischen Defiziten wie Hemiparese, Inaktivität und damit verbundenen dramatischen Gewichtsverlust eine Mortalität von 5% für die Hypothermiegruppe und 30% in der Normothermiegruppe. Dies findet seine Bestätigung auch in anderen experimentellen Untersuchungen. Für die Anwendung von Hypothermie bei Schädel – Hirn –Traumen und zerebralen Ischämien in klinischen Studien ist die Datenlage bisher noch widersprüchlich. Die bisher größte Multicenterstudie in den USA von 1994 -1998 musste bei 392 Patienten mit SHT abgebrochen werden, nachdem kein therapeutischer Effekt unter Hypothermie festzustellen war (Clifton et al., 2001¹). Nähere Analysen zeigten jedoch eine Verbesserung des Outcomes bei Patienten unter 45 Jahren welche bei Aufnahme bereits hypothermen Bedingungen ausgesetzt waren. Damit stellt sich natürlich die Frage nach dem optimalen Zeitfenster für den Beginn einer hypothermen Behandlung. Als therapeutische Konsequenz erscheint damit unter Umständen ein sofortiger Beginn der Hypothermiebehandlung mit Eintreffen des Notarztes als wirkungsvoller. Zusätzlich konnten wiederum neueste Untersuchungen bei Patienten mit zerebraler Ischämie nach Herz- und Kreislaufstillstand einen protektiven Effekt einer moderater Hypothermie auf das neurologische Outcome aufzeigen (Bernard et al., 2002; Holzer et al., 2002).In unserer Studie sollte aber auf keinen Fall der nur geringe Unterschied in der Gesamtmortalität mit 55 % in der normothermen und 45 % in der hypothermen Gruppe vernachlässigt werden. Die Annäherung der Gesamtmortalität war hierbei auf eine deutlich erhöhte Rate systemischer oder lokaler Infektionen unter den hypothermen Tieren zurückzuführen.In klinischen Studien mehren sich allerdings die Hinweise auf eine durch Hypothermie bedingte Immunsuppression und damit verbundenen erhöhten Infektionsneigung. So konnten erhöhte Pneumonieraten (Schwab et al., 1998; 2001 ; Shiozaki et al., 2001) aber auch ein vermehrtes Auftreten von Meningitiden (Shiozaki et al.,2001) beobachtet werden. Shiozaki konnte zudem signifikant erhöhte Raten von Leuko- und Thrombozytopenien sowie Elektrolytentgleisungen im hypothermen Kollektiv finden (Shiozaki et al., 2001). Schwab fand in einer eigens zur Überprüfung der Nebenwirkungen von Hypothermie bei Patienten mit zerebraler Ischämie aufgelegten Studie erhöhte Raten an Pneumonien (48%), Thrombozytopenien (70%) und Bradykardien (62%) (Schwab et al.,2001). Prospektive Studien von Patienten mit kolorektalen Eingriffen wiesen ebenso unter milder Hypothermie signifikant vermehrt Wundheilungsstörungen (Kurz et al., 1996) und eine geringere Lymphozytenaktivität auf (Beilin et al., 1998). Angewandt auf unsere Studie zeigte sich ebenfalls eine erhöhte Rate von Wundheilungsstörungen unter Hypothermie, ohne dabeijedoch zu einer Beeinflussung der Ergebnisse in den neuropsychologischen Testreihen zu führen.Abschließend kann festgehalten werden, dass in dieser Studie die Induktion einer moderaten Hypothermie nach epiduraler, extraaxialer Raumforderung, zu einer Verbesserung neurologischer Defizite und damit zu einer Besserung der Lebensqualität jener Versuchstiere führte, die den Beobachtungszeitraum überlebten. Eine Verringerung der Gesamtmortalität konnte nicht erreicht werden.
IRAK2 besitzt eine Schlüsselrolle im Signalweg des TLR4. Fehlregulationen dieses Signalwegs führen zu fehlgeleiteten Immunreaktionen, die auch die Entstehung und Progression von Krebserkrankungen fördern. Bevor IRAK2 als therapeutisches Ziel in Frage kommen kann, muss erst noch weitere Klarheit über die grundsätzliche Funktionsweise dieses Proteins bestehen. So ist für IRAK2 aufgrund der Substitution einer Aminosäure in der Kinase-Domäne im Vergleich zu IRAK1 noch nicht abschließend geklärt, ob es sich um eine aktive Kinase oder eine Pseudokinase handelt und ob diese Veränderung eine Erhöhung oder eine Erniedrigung der Funktion im TLR4-Signalweg nach sich zieht.
Um diese Fragen anzugehen, wurde in dieser Arbeit Asparagin im vermeintlich aktiven Zentrum (Aminosäure 333) wieder zur Asparaginsäure [N333D] revertiert und damit versucht die Phosphorylierungsaktivität zu steigern bzw. vergleichbar zu IRAK1 wiederherzustellen. Das Einbringen der Mutation in IRAK2 erfolgte mittels ortsspezifischer Mutagenese. Mit dieser und anderen Mutanten und mit wildtypischem IRAK2 wurden durch die CRISPR/Cas9-Methode generierte IRAK2-defiziente 264.7 Makrophagen rekonstituiert und damit ein System etabliert, mit dem der Einfluss der Mutation auf den Signalweg des TLR4 nach Stimulation mit LPS quantitativ analysiert werden konnte. Sowohl die indirekte NF-κB-Messung über CD40-Expression als auch die direkte NF-κB-Messung über die NF-κB-getriebene Expression eines Reportergens (cyan fluorescent protein) ergab, dass IRAK2[N333D] die LPS-abhängige NF-κB-Aktivierung über den TLR4 Signalweg schlechter ermöglicht als IRAK2.
Insgesamt deuten die Ergebnisse darauf hin, dass die in der Entwicklungsgeschichte aufgetretene Veränderung des aktiven Zentrums von IRAK2 im Vergleich zu IRAK1 zu einer besseren Aktivierung der MyD88-abhängigen NF-κB-Aktivität führte und somit eine erhöhte und länger anhaltende Signalleitung ermöglichte. Diese Erkenntnis kann als weiterer Schritt hin zu einem besseren Verständnis der Funktion des IRAK2-Proteins und zu einer möglichen zukünftigen Verwendung von IRAK2 als Ziel therapeutischer Behandlungen gesehen werden.
The Coronavirus disease 2019 (COVID-19) has not only had negative effects on employees' health, but also on their prospects to gain and maintain employment. Using a longitudinal research design with two measurement points, we investigated the ramifications of various psychological and organizational resources on employees' careers during the COVID-19 pandemic. Specifically, in a sample of German employees (N = 305), we investigated the role of psychological capital (PsyCap) for four career-related outcomes: career satisfaction, career engagement, coping with changes in career due to COVID-19, and career-related COVID-19 worries. We also employed leader–member exchange (LMX) as a moderator and career adaptability as a mediating variable in these relationships. Results from path analyses revealed a positive association between PsyCap and career satisfaction and career coping. Furthermore, PsyCap was indirectly related to career engagement through career adaptability. However, moderation analysis showed no moderating role of LMX on the link between PsyCap and career adaptability. Our study contributes to the systematic research concerning the role of psychological and organizational resources for employees' careers and well-being, especially for crisis contexts.
Recht ist ein sehr weiter Begriff. Ob als formaljuristische Normierung oder als Gesamtheit verschieden definierbarer Ordnungssysteme, wie Sitten, Ehre oder Anstand verstanden – wir treten täglich und überall mit dem Recht ins Verhältnis. Doch nehmen wir dies auch wahr? Machen wir es uns bewusst oder sind wir daran gewöhnt, dass Dinge schlicht so richtig sind, wie sie eben sind? Wann werden unsere alltäglichen Routinen durchbrochen und was passiert, wenn hinterfragt wird, was eigentlich selbstverständlich ist?
Diese Arbeit zeichnet zum einen ein Bild, wie wir Recht im Alltag wahrnehmen oder eben gerade nicht wahrnehmen. Dazu werden die Kategorien Recht und Alltag in ihren gegenseitigen Wechselwirkungen am Beispiel Straßenverkehr analysiert und darüber Aspekte der Dinglichkeit mit einbezogen. Anhand der Akteur-Netzwerk-Theorie wird das Verhältnis von Normierung und tatsächlicher Alltagserfahrung durch den Einbezug dinglicher Mittler, wie etwa das rote Ampellicht, erweitert.
Zum anderen sollen aber auch Möglichkeiten aufgezeigt werden, wie eine kulturwissenschaftliche Perspektivierung rechtliche Themen bereichern kann. Qualitative Forschung in alltäglichen Lebenswelten ermöglicht eine erweiterte Sichtweise auf das Recht und kann auch für die Rechtswissenschaften einen fruchtbaren Nährboden bieten, indem vermeintlich Redundantes nicht als so selbstverständlich wahrgenommen wird, wie es auf den ersten Blick vielleicht scheinen mag.
Assessing protein biomarkers to detect lethal acute traumatic brain injuries in cerebrospinal fluid
(2021)
Diagnosing traumatic brain injury (TBI) from body fluids in cases where there are no obvious external signs of impact would be useful for emergency physicians and forensic pathologists alike. None of the previous attempts has so far succeeded in establishing a single biomarker to reliably detect TBI with regards to the sensitivity: specificity ratio in a post mortem setting. This study investigated a combination of body fluid biomarkers (obtained post mortem), which may be a step towards increasing the accuracy of biochemical TBI detection. In this study, serum and cerebrospinal fluid (CSF) samples from 30 acute lethal TBI cases and 70 controls without a TBI-related cause of death were evaluated for the following eight TBI-related biomarkers: brain-derived neurotrophic factor (BDNF), ferritin, glial fibrillary acidic protein (GFAP), interleukin 6 (IL-6), lactate dehydrogenase, neutrophil gelatinase-associated lipocalin (NGAL), neuron-specific enolase and S100 calcium-binding protein B. Correlations among the individual TBI biomarkers were assessed, and a specificity-accentuated threshold value analysis was conducted for all biomarkers. Based on these values, a decision tree modelling approach was performed to assess the most accurate biomarker combination to detect acute lethal TBIs. The results showed that 92.45% of acute lethal TBIs were able to be diagnosed using a combination of IL-6 and GFAP in CSF. The probability of detecting an acute lethal TBI was moderately increased by GFAP alone and considerably increased by the remaining biomarkers. BDNF and NGAL were almost perfectly correlated (p = 0.002; R\(^2\) = 0.944). This study provides evidence that acute lethal TBIs can be detected to a high degree of statistical accuracy using forensic biochemistry. The high inter-individual correlations of biomarkers may help to estimate the CSF concentration of an unknown biomarker, using extrapolation techniques.
A single, specific, sensitive biochemical biomarker that can reliably diagnose a traumatic brain injury (TBI) has not yet been found, but combining different biomarkers would be the most promising approach in clinical and postmortem settings. In addition, identifying new biomarkers and developing laboratory tests can be time-consuming and economically challenging. As such, it would be efficient to use established clinical diagnostic assays for postmortem biochemistry. In this study, postmortem cerebrospinal fluid samples from 45 lethal TBI cases and 47 controls were analyzed using commercially available blood-validated assays for creatine kinase (CK) activity and its heart-type isoenzyme (CK–MB). TBI cases with a survival time of up to two hours showed an increase in both CK and CK–MB with moderate (CK–MB: AUC = 0.788, p < 0.001) to high (CK: AUC = 0.811, p < 0.001) diagnostic accuracy. This reflected the excessive increase of the brain-type CK isoenzyme (CK–BB) following a TBI. The results provide evidence that CK immunoassays can be used as an adjunct quantitative test aid in diagnosing acute TBI-related fatalities.
Background: The use of assisted reproductive techniques (ART) for treatment of infertility is increasing rapidly worldwide. However, various health effects have been reported including a higher risk of congenital malformations. Therefore, we assessed the risk of anorectal malformations (ARM) after in-vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI).
Methods: Data of the German Network for Congenital Uro-REctal malformations (CURE-Net) were compared to nationwide data of the German IVF register and the Federal Statistical Office (DESTATIS). Odds ratios (95% confidence intervals) were determined to quantify associations using multivariable logistic regression accounting for potential confounding or interaction by plurality of births.
Results: In total, 295 ARM patients born between 1997 and 2011 in Germany, who were recruited through participating pediatric surgeries from all over Germany and the German self-help organisation SoMA, were included. Controls were all German live-births (n = 10,069,986) born between 1997 and 2010. Overall, 30 cases (10%) and 129,982 controls (1%) were born after IVF or ICSI, which translates to an odds ratio (95% confidence interval) of 8.7 (5.9-12.6) between ART and ARM in bivariate analyses. Separate analyses showed a significantly increased risk for ARM after IVF (OR, 10.9; 95% CI, 6.2-19.0; P < 0.0001) as well as after ICSI (OR, 7.5; 95% CI, 4.6-12.2; P < 0.0001). Furthermore, separate analyses of patients with isolated ARM, ARM with associated anomalies and those with a VATER/VACTERL association showed strong associations with ART (ORs 4.9, 11.9 and 7.9, respectively). After stratification for plurality of birth, the corresponding odds ratios (95% confidence intervals) were 7.7 (4.6-12.7) for singletons and 4.9 (2.4-10.1) for multiple births. Conclusions: There is a strongly increased risk for ARM among children born after ART. Elevations of risk were seen after both IVF and ICSI. Further, separate analyses of patients with isolated ARM, ARM with associated anomalies and those with a VATER/VACTERL association showed increased risks in each group. An increased risk of ARM was also seen among both singletons and multiple births.
In der vorliegenden experimentellen Arbeit wurde in in-vitro-Modellen der Zusammenhang zwischen Expression der Tumorantigene MAGE-A (melanoma-associated antigenes) und der Wirksamkeit von Chemotherapeutika untersucht. Die MAGE-Antigene MAGE-A1 bis MAGE-A12 (ohne A7) kommen in diversen malignen Tumoren vor; neben Melanomen auch in Tumoren der Lunge, Brust, Prostata, Ovarien, Harnblase, des Gastrointestinal-Trakts und des Kopf-Hals-Bereichs. Bereits vielfach wurden Zusammenhänge zwischen MAGE-A-Tumorantigen-Expression und einer erhöhten Tumorinvasivität, Zellproliferation, Metastasierungsrate und kürzerem Überleben hergestellt. In dieser Arbeit gelang nun der erstmalige Nachweis, dass MAGE-A-Tumorantigene die chemotherapeutische Wirksamkeit beeinflussen. Zunächst gelang der Nachweis, dass die Expression von MAGE-A11 mit geringer Cisplatin-Wirksamkeit korreliert. Eine im Anschluss generierte MAGE-A11 überexprimierende Zelllinie zeigte ein durchschnittlich um 9 % schlechteres Ansprechen auf Cisplatin als die Kontrollzelllinie.
Fluorescence microscopy is a form of light microscopy that has developed during the 20th century and is nowadays a standard tool in Molecular and Cell biology for studying the structure and function of biological molecules. High-resolution fluorescence microscopy techniques, such as dSTORM (direct Stochastic Optical Reconstruction Microscopy) allow the visualization of cellular structures at the nanometre scale (10−9 m). This has already made it possible to decipher the composition and function of various biopolymers, such as proteins, lipids and nucleic acids, up to the three-dimensional (3D) structure of entire organelles. In practice, however, it has been shown that these imaging methods and their further developments still face great challenges in order to achieve an effective resolution below ∼ 10 nm. This is mainly due to the nature of labelling biomolecules. For the detection of molecular structures, immunostaining is often performed as a standard method. Antibodies to which fluorescent molecules are coupled, recognize and bind specifcally and with high affnity to the molecular section of the target structure, also called epitope or antigen. The fluorescent molecules serve as reporter molecules which are imaged with the use of a fluorescence microscope. However, the size of these labels with a length of about 10-15 nm in the case of immunoglobulin G (IgG) antibodies, cause a detection of the fluorescent molecules shifted to the real position of the studied antigen. In dense regions where epitopes are located close to each other, steric hindrance between antibodies can also occur and leads to an insuffcient label density. Together with the shifted detection of fluorescent molecules, these factors can limit the achievable resolution of a microscopy technique. Expansion microscopy (ExM) is a recently developed technique that achieves a resolution improvement by physical expansion of an investigated object. Therefore, biological samples such as cultured cells, tissue sections, whole organs or isolated organelles are chemically anchored into a swellable polymer. By absorbing water, this so-called superabsorber increases its own volume and pulls the covalently bound biomolecules isotropically apart. Routinely, this method achieves a magnifcation of the sample by about four times its volume. But protocol variants have already been developed that result in higher expansion factors of up to 50-fold. Since the ExM technique includes in the frst instance only the sample treatment for anchoring and magnifcation of the sample, it can be combined with various standard methods of fluorescence microscopy. In theory, the resolution of the used imaging technique improves linearly with the expansion factor of the ExM treated sample. However, an insuffcient label density and the size of the antibodies can here again impair the effective achievable resolution. The combination of ExM with high-resolution fluorescence microscopy methods represents a promising strategy to increase the resolution of light microscopy. In this thesis, I will present several ExM variants I developed which show the combination of ExM with confocal microscopy, SIM (Structured Illumination Microscopy), STED (STimulated Emission Depletion) and dSTORM. I optimized existing ExM protocols and developed different expansion strategies, which allow the combination with the respective imaging technique. Thereby, I gained new structural insights of isolated centrioles from the green algae Chlamydomonas reinhardtii by combining ExM with STED and confocal microscopy. In another project, I combined 3D-SIM imaging with ExM and investigated the molecular structure of the so-called synaptonemal complex. This structure is formed during meiosis in eukaryotic cells and contributes to the exchange of genetic material between homologous chromosomes. Especially in combination with dSTORM, the ExM method showed its high potential to overcome the limitations of modern fluorescence microscopy techniques. In this project, I expanded microtubules in mammalian cells, a polymer of the cytoskeleton as well as isolated centrioles from C. reinhardtii. By labelling after expansion of the samples, I was able to signifcantly reduce the linkage error of the label and achieve an improved label density. In future, these advantages together with the single molecule sensitivity and high resolution obtained by the dSTORM method could pave the way for achieving molecular resolution in fluorescence microscopy
Results are presented of cloning cDNA of procine growth hormone, analysis of its primary structure, and creation of a construction capable of expression of this cDNA in Esqheriahia coti cells. It is shown that in the population of mRNA coding porcine growth hormone, heterogeneity is noted which is manifested not only at the level of the nucleotide sequence, but also is reflected in the amino acid sequence of the mature hormone.
Zusammenfassung Einleitung: Der idiopathische Klumpfuß ist die häufigste angeborene Fehlbildung der Extremitäten. Bei ca. 25% der Patienten tritt nach initialer operativer Korrektur ein Klumpfußrezidiv auf. In der vorliegenden Arbeit werden anhand einer retrospektiven klinischen Studie die Ergebnisse der operativen Korrektur residueller Deformitäten an diesem Krankengut dargestellt. Patienten und Methoden: Es wurden 43 Patienten mit 57 Rezidivklumpfüßen, die in der Zeit von 1986-2001 in der orthopädischen Klinik, König-Ludwig-Haus, operativ behandelt wurden, nach einem standardisierten Protokoll klinisch und radiologisch nachuntersucht. Die operative Behandlung erfolgte nach einem standardisierten Schema unter Berücksichtigung der individuellen Deformität der Patienten. Das Durchschnittsalter der Patienten mit einer residuellen Deformität betrug bei der Rezidivoperation 5,1 Jahre, bei der Nachuntersuchung 12,05 Jahre. Die durchschnittliche Nachuntersuchungszeit betrug 6,6 Jahre. Die konservative Vorbehandlung erfolgte bei den in dieser Arbeit evaluierten Patienten nicht einheitlich. Die Patienten wurden primär und bei der Revision nach unterschiedlichen Methoden operiert. Auch die Anzahl der Operationen vor der Revision variierte, wobei 87,7% der Füße nur einmal voroperiert waren. Die klinischen und radiologischen Ergebnisse wurden anhand verschiedener Bewertungssysteme (Simons, Mc Kay, Lehman und Würzburger Schema) ausgewertet und in Bezug auf das gesamte nachuntersuchte Patientenkollektiv und einer als Rezidivoperation durchgeführten peritalaren Arthrolyse dargestellt. Ergebnisse: Klinische Ergebnisse: Im Gesamtkollektiv der Rezidivklumpfüße wurde nach der Auswertung des klinischen Anamnesebogens durchschnittlich ein gutes Ergebnis erzielt. Im Vergleich der beiden Gruppen (Gruppe 1: Patienten mit einer peritalaren Arthrolyse als Rezidivoperation; Gruppe 2: Patienten, die keine peritalare Arthrolyse als Rezidivoperation hatten) zeigte sich sowohl bei den subjektiven als auch bei den objektiven Parametern der Trend zu einem besseren Ergebnis in der Gruppe 1, ein statistisch signifikanter Unterschied in den beiden Gruppen konnte nicht festgestellt werden. Bewertungsschemata: Die 57 nachuntersuchten Rezidivklumpfüße erreichten nach der Auswertung nach Lehman und nach Mc Kay ein zufrieden stellendes Ergebnis, im Gegensatz dazu fiel das Gesamtergebnis nach Simons’ Bewertungsschema bei 71,7% der nachuntersuchten Patienten nicht zufrieden stellend aus. Im Gruppenvergleich zeigt sich bei den Ergebnissen nach Simons und nach Mc Kay der Trend dahingehend, dass die Patienten (Füße) der Gruppe 1 besser abschnitten als die Patienten (Füße) der Gruppe 2. Radiologische Ergebnisse: Nach der Auswertung aller radiologischen Ergebnisse, war nach dem Rezidiveingriff im Durchschnitt keine statistisch signifikante Verbesserung der gemessenen Winkelwerte festzustellen. Schlussfolgerung: In der vorliegenden Arbeit konnte gezeigt werden, dass es kein Operationsverfahren gibt, welches im Vergleich zu anderen Verfahren zu einem statistisch signifikant besseren Ergebnis führt. Jeder Patient - jeder Fuß - muss individuell betrachtet werden. Eine sorgfältige klinische Untersuchung eines erfahrenen Operateurs und die Auswertung standardisierter Röntgenbilder im a.-p. und seitlichen Strahlengang sind außerdem für die Entscheidung über die weitere operative Therapie und für das Erreichen eines funktionell guten Ergebnisses von großer Wichtigkeit. Die beste Behandlung eines Rezidiv- bzw. Residualklumpfußes ist jedoch die Prophylaxe durch eine adäquate Primärbehandlung und Nachsorge.
Microstructural changes and the understanding of their effect on photocurrent generation are key aspects for improving the efficiency of organic photovoltaic devices. We analyze the impact of a systematically increased amount of the solvent additive diiodooctane (DIO) on the morphology of PBDTTT-C:PC71BM blends and related changes in free carrier formation and recombination by combining surface imaging, photophysical and charge extraction techniques. We identify agglomerates visible in AFM images of the 0% DIO blend as PC71BM domains embedded in an intermixed matrix phase. With the addition of DIO, a decrease in the size of fullerene domains along with a demixing of the matrix phase appears for 0.6% and 1% DIO. Surprisingly, transient absorption spectroscopy reveals an efficient photogeneration already for the smallest amount of DIO, although the largest efficiency is found for 3% DIO. It is ascribed to a fine-tuning of the blend morphology in terms of the formation of interpenetrating donor and acceptor phases minimizing geminate and nongeminate recombination as indicated by charge extraction experiments. An increase in the DIO content to 10% adversely affects the photovoltaic performance, most probably due to an inefficient free carrier formation and trapping in a less interconnected donor-acceptor network.
Organic solar cells have great potential to become a low-cost and clean alternative to conventional photovoltaic technologies based on the inorganic bulk material silicon. As a highly promising concept in the field of organic photovoltaics, bulk heterojunction (BHJ) solar cells consist of a mixture of an electron donating and an electron withdrawing component. Their degree of intermixing crucially affects the generation of photocurrent. In this work, the effect of an altered blend morphology on polaron pair dissociation, charge carrier transport, and nongeminate recombination is analyzed by the charge extraction techniques time delayed collection field (TDCF) and open circuit corrected transient charge extraction (OTRACE). Different comparative studies cover a broad range of material systems, including polymer and small-molecule donors in combination with different fullerene acceptors. The field dependence of polaron pair dissociation is analyzed in blends based on the polymer pBTTT-C16, allowing a systematic tuning of the blend morphology by varying the acceptor type and fraction. The effect of both excess photon energy and intercalated phases are minor compared to the influence of excess fullerene, which reduces the field dependence of photogeneration. The study demonstrates that the presence of neat fullerene domains is the major driving force for efficient polaron pair dissociation that is linked to the delocalization of charge carriers. Furthermore, the influence of the processing additive diiodooctane (DIO) is analyzed using the photovoltaic blends PBDTTT-C:PC71BM and PTB7:PC71BM. The study reveals amulti-tiered alteration of the blend morphology of PBDTTT-C based blends upon a systematic increase of the amount of DIO. Domains on the hundred nanometers length scale in the DIO-free blend are identified as neat fullerene agglomerates embedded in an intermixed matrix. With the addition of the additive, 0.6% and 1% DIO already substantially reduces the size of these domains until reaching the optimum 3% DIO mixture, where a 7.1% power conversion efficiency is obtained. It is brought into connection with the formation of interpenetrating polymer and fullerene phases. Similar to PBDTTT-C, the morphology of DIO-free PTB7:PC71BM blends is characterized by large fullerene domains being decreased in size upon the addition of 3% DIO. OTRACE measurements reveal a reduced Langevin-type, super-second order recombination in both blends. It is demonstrated that the deviation from bimolecular recombination kinetics cannot be fully attributed to the carrier density dependence of the mobility but is rather related to trapping in segregated PC71BM domains. Finally, with regard to small-molecule donors, a higher yield of photogeneration and balanced transport properties are identified as the dominant factors enhancing the efficiency of vacuum deposited MD376:C60 relative to its solution processed counterpart MD376:PC61BM. The finding is explained by a higher degree of dimerization of the merocyanine dye MD376 and a stronger donor-acceptor interaction at the interface in the case of the vacuum deposited blend.
Die Rezeptsammlung "Freywillig auffgesprungener Granat-Apffel des Christlichen Samaritans" wurde erstmals 1695 in Wien publiziert. Verfasserin dieses in über zwanzig Auflagen erschienenen Werkes ist die Fürstin Eleonora Maria Rosalia von Eggenberg (1647–1703), geborene Fürstin von Liechtenstein und seinerzeitige Herzogin zu Troppau und Jaegerndorff. Mit der vorliegenden Arbeit wurde das medizinische Werk der Eleonora von Eggenberg systematisch erfasst und mit modernem Wissen verglichen.
In den letzten Jahren wurden verstärkt die Auswirkungen von Androgenen auf das kardiovaskuläre System des Menschen untersucht, wobei das mögliche Wirkspektrum sowohl positive als auch negative Aspekte umfasst. Anzumerken ist jedoch, dass gerade negative Beobachtungen, wie der plötzliche Herztod von Bodybuildern nach Androgenmissbrauch, jeweils Einzelfalldarstellungen sind und klinische Studien hierzu fehlen. Epidemiologische Daten zeigen wiederum eine höhere Lebenserwartung von Männern nach Herzinfarkt im Vergleich zu Frauen. Es existieren jedoch keinerlei Angaben darüber, welchen Einfluss Androgene auf das kardiovaskuläre Remodeling nach einem Herzinfarkt haben. Dazu wurden von uns männliche Wistar-Ratten entweder orchiektomiert (ORCH), nicht orchiektomiert (PLAC) oder aber mit supraphysiologischen Dosierungen von Testosteronundecanoat (TUD) intramuskulär behandelt. Vierzehn Tage später erfolgte entweder eine Infarzierung (MI) oder Scheininfarzierung (SHAM) dieser Tiere, acht Wochen danach die kernspintomographische, echokardiographische und hämodynamische Evaluierung der linksventrikulären Funktion. Ferner wurden molekularbiologische Marker wie ANP, MHC und IGF-1 untersucht, um so das kardiale Remodeling näher zu charakterisieren. Bei den scheininfarzierten Tieren führte die Testosteronapplikation zu einer kardialen Hypertrophie (SHAM/TUD vs. SHAM/PLAC und SHAM/ORCH, p<0,02) ohne Erhöhung von ANP-mRNA. Der Quotient aus a/b-MHC war nach Testosteronbehandlung durch verstärkte Expression von a-MHC signifikant höher (SHAM/ORCH vs. SHAM/TUD, p<0,05). Als potentieller Mechanismus dieser Hypertrophieform war die Expression von IGF-1-mRNA fünffach erhöht (SHAM/PLAC und SHAM/ORCH vs. SHAM/TUD, p<0,05). Nach Infarzierung war die Infarktgrösse mit durchschnittlich 38 % und auch die infarktassoziierte Mortalität mit ca. 60% zwischen den Gruppen vergleichbar. Bei der auf das Körpergewicht bezogenen linksventrikulären Masse führte Testosteron zu einer signifikant verstärkten Hypertrophie (MI/TUD vs. MI/PLAC und MI/ORCH p<0,01), der linksventrikuläre enddiastolische Druck war unter Testosteronbehandlung niedriger (MI/TUD vs. MI/PLAC, 14±3 vs. 26±2 mmHg, p<0.02). Durch die Infarzierung erhöhte sich in allen Gruppen die Expression von ANP im Vergleich zu scheininfarzierten Tieren (SHAM vs. PLAC p<0,05), der Quotient aus a/b-MHC unterschied sich trotz testosteroninduzierter Hypertrophie innerhalb der infarzierten Gruppen nicht. Keine Unterschiede zeigten sich auch im myokardialen Kollagengehalt (MI/PLAC vs. MI/TUD vs. MI/ORCH 16.8±8% vs. 16.6±5% vs. 19.0±11%, p=ns). Chronische Testosteronbehandlung führte zu einer spezifischen kardialen Hypertrophie mit signifikanter Erhöhung des linksventrikulären Gewichtes, die nicht durch einen Anstieg von ANP als einem Marker der remodelinginduzierten Hypertrophie charakterisiert war. Ferner führte Testosteron zu einer verstärkten Expression der „schnellen“ a-MHC-Isoform, so dass der beim kardialen Remodeling sonst sinkende Quotient aus a/b-MHC unter Testosteronbehandlung nicht beobachtet wurde. Möglicherweise sind diese Effekte auf eine erhöhte Expression von IGF-1-mRNA zurückzuführen. Bei gleichzeitig erniedrigtem LVEDP als einem wichtigen Prognosefaktor der Herzinsuffizienz kann eine physiologische Form der Hypertrophie hypothetisiert werden. Testosteron scheint also am Herz ein spezifisches „physiologisches“ Hypertrophieprogramm zu induzieren, das die kardiale Funktion nach Myokardinfarkt möglicherweise langfristig positiv beeinflusst.
Government funding of research beyond biomedicine: challenges and opportunities for neuroethology
(2022)
Curiosity-driven research is fundamental for neuroethology and depends crucially on governmental funding. Here, we highlight similarities and differences in funding of curiosity-driven research across countries by comparing two major funding agencies—the National Science Foundation (NSF) in the United States and the German Research Foundation (Deutsche Forschungsgemeinschaft, DFG). We interviewed representatives from each of the two agencies, focusing on general funding trends, levels of young investigator support, career-life balance, and international collaborations. While our analysis revealed a negative trend in NSF funding of biological research, including curiosity-driven research, German researchers in these areas have benefited from a robust positive trend in DFG funding. The main reason for the decrease in curiosity-driven research in the US is that the NSF has only partially been able to compensate for the funding gap resulting from the National Institutes of Health restricting their support to biomedical research using select model organisms. Notwithstanding some differences in funding programs, particularly those relevant for scientists in the postdoctoral phase, both the NSF and DFG clearly support curiosity-driven research.