Filtern
Volltext vorhanden
- ja (52)
Gehört zur Bibliographie
- ja (52)
Erscheinungsjahr
Dokumenttyp
- Artikel / Aufsatz in einer Zeitschrift (52) (entfernen)
Sprache
- Englisch (52)
Schlagworte
- mice (7)
- ADHD (6)
- anxiety (5)
- depression (5)
- serotonin (5)
- hippocampus (4)
- animal behavior (3)
- chronic stress (3)
- emotion (3)
- knockout mice (3)
- prefrontal cortex (3)
- psychiatric disorders (3)
- DNA methylation (2)
- FAAH (2)
- Serotonin (2)
- aggression (2)
- aging (2)
- anxiety-like behavior (2)
- attention-deficit/hyperactivity disorder (ADHD) (2)
- behavior (2)
- chronic heart failure (2)
- endocannabinoid (2)
- genetics (2)
- inflammation (2)
- insulin receptor (2)
- knockout (2)
- mouse (2)
- myelination (2)
- myocardial infarction (2)
- neurodevelopment (2)
- oxidative stress (2)
- pro-inflammatory cytokines (2)
- serotonin transporter (2)
- serotonin transporter gene (2)
- startle reflex (2)
- 3-dimensional MRI (1)
- 5-HT receptors (1)
- 5-HT transporter (1)
- 5-HT1A receptor (1)
- 5-HTT (1)
- 5-HTT knockout mice (1)
- 5-HTTLPR (1)
- 5-HTTLPR polymorphism (1)
- Abelson helper integration-1 (AHI1) (1)
- Activation (1)
- Acute tryptophan depletion (1)
- Adult (1)
- Aggression (1)
- Aggressive behaviour (1)
- Antisocial behavior (1)
- Anxiety-like behavior (1)
- Association (1)
- Attention Deficit Hyperactivity Disorder (ADHD) (1)
- BDNF (1)
- BDNF Val66Met (1)
- Big Five (1)
- Bipolar disorder (1)
- C57BL/6 mice (1)
- CB1 receptor antagonists (1)
- CDH13 (1)
- CDH13 Expression (1)
- CDH13 mRNA (1)
- CRISPR-Cas Systems (1)
- Cadherin (CDH13) (1)
- Cadherin-13 (CDH13) (1)
- Central nervous system (1)
- Chronic stress (1)
- Conduct disorder (1)
- Cytokines (1)
- Deficit/hyperactivity disorder (1)
- Depression (1)
- Diagnostic approach (1)
- Dopamine (1)
- Fgf-signalling (1)
- GABA (1)
- GAD1 (1)
- GWAS (1)
- Gene (1)
- Human CDH13 (1)
- Hypothalamus (1)
- Induced Pluripotent Stem Cells (1)
- Insensitivity (1)
- Interferon-alpha (1)
- Knock-out mice (1)
- LPS (1)
- Large multicenter ADHD (1)
- Long-term depression (1)
- Major depression (1)
- Medizin (1)
- Messenger-RNA (1)
- Mice (1)
- Mood disorders (1)
- Mouse-brain (1)
- NMDA receptor subunits NR2A and NR2B (1)
- Neuronal plasticity (1)
- Physiological functions (1)
- RNA expression (1)
- Rat-brain (1)
- Rating scale (1)
- Restraint stress (1)
- S-HT (1)
- SARS-CoV-2 (1)
- SERT (1)
- SLC2A3 (1)
- SSRI (1)
- Schizophrenie (1)
- Serotonin transporter (1)
- Serotonin transporter polymorphism (1)
- Sert-deficient mice (1)
- Susceptibility loci (1)
- T-cadherin (1)
- Toll-like receptor 4 (TLR4) (1)
- Tryptophan hydroxylase-2 (Tph2) (1)
- Western diet (1)
- Xenopus laevis oocytes (1)
- adolescence (1)
- adulthood (1)
- adversity (1)
- affective state (1)
- aggressiveness (1)
- agreeableness (1)
- allostatic load (1)
- amino acid analysis (1)
- anhedonia (1)
- animal performance (1)
- antidepressant (1)
- antidepressants (1)
- antioxidant nutrients (1)
- anxiety disorders (1)
- anxiety like (1)
- association (1)
- astrocytes (1)
- attention (1)
- attentional bias (1)
- autism-like behavior (1)
- autoinhibition (1)
- blood flow (1)
- brain development (1)
- brain disorders (1)
- cadherin-13 (CDH13) (1)
- cadherins (1)
- celecoxib (1)
- cell membranes (1)
- childhood maltreatment (1)
- chronic social stress (1)
- citalopram (1)
- collagens (1)
- comparative genomics (1)
- congenital heart-deffects (1)
- coping with challenge (1)
- copy-number variation (1)
- corticotropin releasing factor (1)
- crystal structure (1)
- dangerous world (1)
- deficient mice (1)
- developmental plasticity (1)
- dicholine succinate (1)
- diet (1)
- dorsal raphe (1)
- dorsal raphe nucleus (1)
- electroencephalogram (EEG) (1)
- elevated plus-maze (1)
- emotional behavior (1)
- emotional information (1)
- energy expenditure (1)
- environment interaction (1)
- environmental enrichment (1)
- events (1)
- evolutionary biology (1)
- executive function training (1)
- executive functions (1)
- expression (1)
- extinction (1)
- fear (1)
- fear conditioning (1)
- fear learning (1)
- female (1)
- female aggression (1)
- forced swimming (1)
- gene-by-environment interaction (1)
- geneexpression (1)
- genetic variants (1)
- genomic analysis (1)
- genomics (1)
- glia (1)
- glucose (1)
- glucose tolerance (1)
- glucose transporter (1)
- glycogen synthase kinase-3 β (GSK-3β) (1)
- heterosis (1)
- heterozygote (1)
- hippocampal neurogenesis (1)
- hippocampal plasticity (1)
- human induced pluripotent stem cell (hiPSC) (1)
- humans (1)
- hyperactivity (1)
- immediate early genes (1)
- immediate-early gene (1)
- impulsivity (1)
- in vivo (1)
- induced pluripotent stem cells (1)
- inducible cyclooxygenase-2 (COX-2) (1)
- inflammatory diseases (1)
- insulin receptor (IR) (1)
- integrins (1)
- ischemic stroke (1)
- judgement bias (1)
- knock-out mice (1)
- laboratory environment (1)
- lacking (1)
- lactosylceramide alpha-2,3-sialyltransferase (ST3GAL5) (1)
- learning (1)
- learning curves (1)
- lerned helplessness (1)
- life history (1)
- life stress (1)
- linked polymorphic region (1)
- locomotor activity (1)
- long-term potentiation (1)
- major depression (1)
- major depressive disorder (MDD) (1)
- match-mismatch (1)
- maternal care (1)
- maternal separation (1)
- mechanismofaction (1)
- median and dorsal raphe (1)
- membrane potential (1)
- membrane proteins (1)
- metaanalysis (1)
- middle aged (1)
- moderation (1)
- molecular neuroscience (1)
- monoamine transporters (1)
- mouse model (1)
- mouse-brain (1)
- nervous system (1)
- neurodevelopmental disorders / genetics (1)
- neuroinflammation (1)
- neuronal plasticity (1)
- neuropsychiatric disorders (1)
- nitricoxidesynthase (1)
- nucleus (1)
- obesity (1)
- panic disorder (1)
- phosphorylated glycogen synthase kinase-3beta (pGSK-3beta) (1)
- plasticity (1)
- platelet activation (1)
- platelet aggregation (1)
- platelets (1)
- polygenic risk score (1)
- polymorphism (1)
- post-traumatic stress disorder (1)
- predation stress (1)
- predictive adaptive response hypothesis (1)
- primary response genes (1)
- promoter region (1)
- radial glia (1)
- rare mendelian disorders (1)
- rat brain (1)
- receptors (1)
- regulatory T cells (1)
- response inhibition (1)
- rhesus macaques (1)
- s allele (1)
- serotonin deficiency (1)
- serotonin receptors (1)
- serotonin transporter deficient mice (1)
- serotonin-specific neurons (1)
- sex differences (1)
- sialic acid (1)
- sialyltransferase (1)
- sleep EEG (1)
- social experience (1)
- spatial memory (1)
- stress resilience (1)
- substance abuse disorder (1)
- swim test (1)
- synapse formation (1)
- telomere length (1)
- toll-like receptors (1)
- transporter gene SLC2A3 (1)
- treatment guidelines (1)
- tryptophan (1)
- tryptophan hydroxylase 2 (1)
- tryptophan hydroxylase-2 (1)
- tryptophan hydroxylase-2 (Tph2) (1)
- venturesomeness (1)
- white-matter integrity (1)
- working memory (1)
Institut
- Klinik und Poliklinik für Psychiatrie, Psychosomatik und Psychotherapie (33)
- Lehrstuhl für Molekulare Psychiatrie (20)
- Institut für Humangenetik (5)
- Klinik und Poliklinik für Kinder- und Jugendpsychiatrie, Psychosomatik und Psychotherapie (5)
- Theodor-Boveri-Institut für Biowissenschaften (5)
- Physiologisches Institut (3)
- Institut für Anatomie und Zellbiologie (2)
- Institut für Psychologie (2)
- Medizinische Klinik und Poliklinik I (2)
- Neurologische Klinik und Poliklinik (2)
Prenatal stress (PS) has been shown to influence the development of the fetal brain and to increase the risk for the development of psychiatric disorders in later life. Furthermore, the variation of human serotonin transporter (5-HTT, SLC6A4) gene was suggested to exert a modulating effect on the association between early life stress and the risk for depression. In the present study, we used a 5-Htt6PS paradigm to investigate whether the effects of PS are dependent on the 5-Htt genotype. For this purpose, the effects of PS on cognition, anxiety- and depression-related behavior were examined using a maternal restraint stress paradigm of PS in C57BL6 wild-type (WT) and heterozygous 5-Htt deficient (5-Htt +/2) mice. Additionally, in female offspring, a genome-wide hippocampal gene expression profiling was performed using the Affymetrix GeneChipH Mouse Genome 430 2.0 Array. 5-Htt +/2 offspring showed enhanced memory performance and signs of reduced anxiety as compared to WT offspring. In contrast, exposure of 5-Htt +/2 mice to PS was associated with increased depressive-like behavior, an effect that tended to be more pronounced in female offspring. Further, 5-Htt genotype, PS and their interaction differentially affected the expression of numerous genes and related pathways within the female hippocampus. Specifically, MAPK and neurotrophin signaling were regulated by both the 5-Htt +/2 genotype and PS exposure, whereas cytokine and Wnt signaling were affected in a 5-Htt genotype6PS manner, indicating a gene6environment interaction at the molecular level. In conclusion, our data suggest that although the 5-Htt +/2 genotype shows clear adaptive capacity, 5-Htt +/2 mice –particularly females– at the same time appear to be more vulnerable to developmental stress exposure when compared to WT offspring. Moreover, hippocampal gene expression profiles suggest that distinct molecular mechanisms mediate the behavioral effects of the 5-Htt genotype, PS exposure, and their interaction.
Impact of the AHI1 Gene on the Vulnerability to Schizophrenia: A Case-Control Association Study
(2010)
Background: The Abelson helper integration-1 (AHI1) gene is required for both cerebellar and cortical development in humans. While the accelerated evolution of AHI1 in the human lineage indicates a role in cognitive (dys)function, a linkage scan in large pedigrees identified AHI1 as a positional candidate for schizophrenia. To further investigate the contribution of AHI1 to the susceptibility of schizophrenia, we evaluated the effect of AHI1 variation on the vulnerability to psychosis in two samples from Spain and Germany. Methodology/Principal Findings: 29 single-nucleotide polymorphisms (SNPs) located in a genomic region including the AHI1 gene were genotyped in two samples from Spain (280 patients with psychotic disorders; 348 controls) and Germany (247 patients with schizophrenic disorders; 360 controls). Allelic, genotypic and haplotype frequencies were compared between cases and controls in both samples separately, as well as in the combined sample. The effect of genotype on several psychopathological measures (BPRS, KGV, PANSS) assessed in a Spanish subsample was also evaluated. We found several significant associations in the Spanish sample. Particularly, rs7750586 and rs911507, both located upstream of the AHI1 coding region, were found to be associated with schizophrenia in the analysis of genotypic (p = 0.0033, and 0.031,respectively) and allelic frequencies (p = 0.001 in both cases). Moreover, several other risk and protective haplotypes were detected (0.006,p,0.036). Joint analysis also supported the association of rs7750586 and rs911507 with the risk for schizophrenia. The analysis of clinical measures also revealed an effect on symptom severity (minimum P value = 0.0037). Conclusions/Significance: Our data support, in agreement with previous reports, an effect of AHI1 variation on the susceptibility to schizophrenia in central and southern European populations.