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Institute
- Medizinische Klinik und Poliklinik II (9)
- Neurologische Klinik und Poliklinik (5)
- Institut für Organische Chemie (4)
- Medizinische Klinik und Poliklinik I (4)
- Pathologisches Institut (4)
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- Klinik und Poliklinik für Nuklearmedizin (3)
- Klinik und Poliklinik für Psychiatrie, Psychosomatik und Psychotherapie (3)
- Theodor-Boveri-Institut für Biowissenschaften (3)
- Comprehensive Cancer Center Mainfranken (2)
Sonstige beteiligte Institutionen
Kämmerer, Peer W. ; Tribius, Silke ; Cohrs, Lena ; Engler, Gabriel ; Ettl, Tobias ; Freier, Kolja ; Frerich, Bernhard ; Ghanaati, Shahram ; Gosau, Martin ; Haim, Dominik ; Hartmann, Stefan ; Heiland, Max ; Herbst, Manuel ; Hoefert, Sebastian ; Hoffmann, Jürgen ; Hölzle, Frank ; Howaldt, Hans-Peter ; Kreutzer, Kilian ; Leonhardt, Henry ; Lutz, Rainer ; Moergel, Maximilian ; Modabber, Ali ; Neff, Andreas ; Pietzka, Sebastian ; Rau, Andrea ; Reichert, Torsten E. ; Smeets, Ralf ; Sproll, Christoph ; Steller, Daniel ; Wiltfang, Jörg ; Wolff, Klaus-Dietrich ; Kronfeld, Kai ; Al-Nawas, Bilal
(1) Background: Evaluation of impact of adjuvant radiation therapy (RT) in patients with oral squamous cell carcinoma of the oral cavity/oropharynx (OSCC) of up to 4 cm (pT1/pT2) and solitary ipsilateral lymph node metastasis (pN1). A non-irradiated group with clinical follow-up was chosen for control, and survival and quality of life (QL) were compared; (2) Methods: This prospective multicentric comprehensive cohort study included patients with resected OSCC (pT1/pT2, pN1, and cM0) who were allocated into adjuvant radiation therapy (RT) or observation. The primary endpoint was overall survival. Secondary endpoints were progression-free survival and QL after surgery; (3) Results: Out of 27 centers, 209 patients were enrolled with a median follow-up of 3.4 years. An amount of 137 patients were in the observation arm, and 72 received adjuvant irradiation. Overall survival did not differ between groups (hazard ratio (HR) 0.98 [0.55–1.73], p = 0.94). There were fewer neck metastases (HR 0.34 [0.15–0.77]; p = 0.01), as well as fewer local recurrences (HR 0.41 [0.19–0.89]; p = 0.02) under adjuvant RT. For QL, irradiated patients showed higher values for the symptom scale pain after 0.5, two, and three years (all p < 0.05). After six months and three years, irradiated patients reported higher symptom burdens (impaired swallowing, speech, as well as teeth-related problems (all p < 0.05)). Patients in the RT group had significantly more problems with mouth opening after six months, one, and two years (p < 0.05); (4) Conclusions: Adjuvant RT in patients with early SCC of the oral cavity and oropharynx does not seem to influence overall survival, but it positively affects progression-free survival. However, irradiated patients report a significantly decreased QL up to three years after therapy compared to the observation group.
Gröbner, Susanne N. ; Worst, Barbara C. ; Weischenfeldt, Joachim ; Buchhalter, Ivo ; Kleinheinz, Kortine ; Rudneva, Vasilisa A. ; Johann, Pascal D. ; Balasubramanian, Gnana Prakash ; Segura-Wang, Maia ; Brabetz, Sebastian ; Bender, Sebastian ; Hutter, Barbara ; Sturm, Dominik ; Pfaff, Elke ; Hübschmann, Daniel ; Zipprich, Gideon ; Heinold, Michael ; Eils, Jürgen ; Lawerenz, Christian ; Erkek, Serap ; Lambo, Sander ; Waszak, Sebastian ; Blattmann, Claudia ; Borkhardt, Arndt ; Kuhlen, Michaela ; Eggert, Angelika ; Fulda, Simone ; Gessler, Manfred ; Wegert, Jenny ; Kappler, Roland ; Baumhoer, Daniel ; Stefan, Burdach ; Kirschner-Schwabe, Renate ; Kontny, Udo ; Kulozik, Andreas E. ; Lohmann, Dietmar ; Hettmer, Simone ; Eckert, Cornelia ; Bielack, Stefan ; Nathrath, Michaela ; Niemeyer, Charlotte ; Richter, Günther H. ; Schulte, Johannes ; Siebert, Reiner ; Westermann, Frank ; Molenaar, Jan J. ; Vassal, Gilles ; Witt, Hendrik ; Burkhardt, Birgit ; Kratz, Christian P. ; Witt, Olaf ; van Tilburg, Cornelis M. ; Kramm, Christof M. ; Fleischhack, Gudrun ; Dirksen, Uta ; Rutkowski, Stefan ; Frühwald, Michael ; Hoff, Katja von ; Wolf, Stephan ; Klingebeil, Thomas ; Koscielniak, Ewa ; Landgraf, Pablo ; Koster, Jan ; Resnick, Adam C. ; Zhang, Jinghui ; Liu, Yanling ; Zhou, Xin ; Waanders, Angela J. ; Zwijnenburg, Danny A. ; Raman, Pichai ; Brors, Benedikt ; Weber, Ursula D. ; Northcott, Paul A. ; Pajtler, Kristian W. ; Kool, Marcel ; Piro, Rosario M. ; Korbel, Jan O. ; Schlesner, Matthias ; Eils, Roland ; Jones, David T. W. ; Lichter, Peter ; Chavez, Lukas ; Zapatka, Marc ; Pfister, Stefan M.
Pan-cancer analyses that examine commonalities and differences among various cancer types have emerged as a powerful way to obtain novel insights into cancer biology. Here we present a comprehensive analysis of genetic alterations in a pan-cancer cohort including 961 tumours from children, adolescents, and young adults, comprising 24 distinct molecular types of cancer. Using a standardized workflow, we identified marked differences in terms of mutation frequency and significantly mutated genes in comparison to previously analysed adult cancers. Genetic alterations in 149 putative cancer driver genes separate the tumours into two classes: small mutation and structural/copy-number variant (correlating with germline variants). Structural variants, hyperdiploidy, and chromothripsis are linked to TP53 mutation status and mutational signatures. Our data suggest that 7–8% of the children in this cohort carry an unambiguous predisposing germline variant and that nearly 50% of paediatric neoplasms harbour a potentially druggable event, which is highly relevant for the design of future clinical trials.
A shear-dependent NO-cGMP-cGKI cascade in platelets acts as an auto-regulatory brake of thrombosis
(2018)
Wen, Lai ; Feil, Susanne ; Wolters, Markus ; Thunemann, Martin ; Regler, Frank ; Schmidt, Kjestine ; Friebe, Andreas ; Olbrich, Marcus ; Langer, Harald ; Gawaz, Meinrad ; de Wit, Cor ; Feil, Robert
Mechanisms that limit thrombosis are poorly defined. One of the few known endogenous platelet inhibitors is nitric oxide (NO). NO activates NO sensitive guanylyl cyclase (NO-GC) in platelets, resulting in an increase of cyclic guanosine monophosphate (cGMP). Here we show, using cGMP sensor mice to study spatiotemporal dynamics of platelet cGMP, that NO-induced cGMP production in pre-activated platelets is strongly shear-dependent. We delineate a new mode of platelet-inhibitory mechanotransduction via shear-activated NO-GC followed by cGMP synthesis, activation of cGMP-dependent protein kinase I (cGKI), and suppression of Ca2+ signaling. Correlative profiling of cGMP dynamics and thrombus formation in vivo indicates that high cGMP concentrations in shear-exposed platelets at the thrombus periphery limit thrombosis, primarily through facilitation of thrombus dissolution. We propose that an increase in shear stress during thrombus growth activates the NO-cGMP-cGKI pathway, which acts as an auto-regulatory brake to prevent vessel occlusion, while preserving wound closure under low shear.