610 Medizin und Gesundheit
Refine
Is part of the Bibliography
- yes (547)
Year of publication
Document Type
- Journal article (288)
- Doctoral Thesis (256)
- Conference Proceeding (3)
Keywords
- Herzinsuffizienz (25)
- Herzinfarkt (19)
- myocardial infarction (19)
- Diabetes mellitus (18)
- adrenocortical carcinoma (18)
- chronic kidney disease (18)
- heart failure (18)
- inflammation (13)
- Fabry disease (12)
- echocardiography (12)
- hemodialysis (11)
- mortality (11)
- MRI (9)
- Myokardinfarkt (9)
- Arteriosklerose (8)
- Chronische Herzinsuffizienz (8)
- Hämodialyse (8)
- PET (8)
- biomarker (8)
- diabetes (8)
- heart (8)
- prognosis (8)
- Fabry-Krankheit (7)
- Morbus Fabry (7)
- Transthorakale Echokardiographie (7)
- cardiomyopathy (7)
- depression (7)
- diabetes mellitus (7)
- therapy (7)
- Aortenstenose (6)
- CXCR4 (6)
- Chronische Niereninsuffizienz (6)
- Depression (6)
- Dialyse (6)
- Heart failure (6)
- Nebenniere (6)
- Nebennierenrindenkarzinom (6)
- Sterblichkeit (6)
- Stickstoffmonoxid (6)
- atherosclerosis (6)
- cortisol (6)
- eNOS (6)
- oxidative stress (6)
- Aortenklappenstenose (5)
- Atherosklerose (5)
- Endothel (5)
- Kardiologie (5)
- Koronare Herzkrankheit (5)
- Mausmodell (5)
- NMR-Tomographie (5)
- Nebennierenrindenkrebs (5)
- Nierentransplantation (5)
- Remodeling (5)
- Reperfusion (5)
- Simulation (5)
- TAVI (5)
- Ultraschallkardiographie (5)
- blood pressure (5)
- cardiovascular diseases (5)
- coronary artery disease (5)
- dialysis (5)
- fibrosis (5)
- hypertension (5)
- obesity (5)
- paraganglioma (5)
- pheochromocytoma (5)
- type 2 diabetes (5)
- 18F-FDG (4)
- ACC (4)
- Aortenklappenersatz (4)
- Chemotherapie (4)
- Cushing’s syndrome (4)
- DHEA (4)
- Dehydroepiandrosteron (4)
- EKG (4)
- Echokardiographie (4)
- FGFR (4)
- Fettsucht (4)
- Herzkatheter (4)
- Herzmuskel (4)
- Hypertonie (4)
- Kernspintomografie (4)
- Lebensqualität (4)
- Lungenfibrose (4)
- Maus (4)
- Nebennierentumor (4)
- Nierenfunktion (4)
- Ratte (4)
- Strahlentherapie (4)
- Training (4)
- Zellkultur (4)
- acute heart failure (4)
- adrenal (4)
- akute Herzinsuffizienz (4)
- biomarkers (4)
- chronic heart failure (4)
- cognitive decline (4)
- cytokines (4)
- diagnosis (4)
- end-stage renal disease (4)
- enzyme replacement therapy (4)
- hypercortisolism (4)
- immune response (4)
- ischemia (4)
- kidney (4)
- miRNA (4)
- positron emission tomography (4)
- prevalence (4)
- reperfusion (4)
- survival (4)
- theranostics (4)
- ACTH (3)
- Adipositas (3)
- COVID-19 (3)
- Diabetes (3)
- Doppler-Echokardiographie (3)
- ECG (3)
- Elektrokardiogramm (3)
- Endotheldysfunktion (3)
- Erythropoietin (3)
- Fibrose (3)
- Gewebedoppler (3)
- Guanylatcyclase (3)
- Herzfrequenz (3)
- Herzhypertrophie (3)
- Immunreaktion (3)
- Inflammation (3)
- Ischämie (3)
- Kardiomyopathie (3)
- Myocardial infarction (3)
- Myokarditis (3)
- NMR (3)
- Nebennierenkarzinom (3)
- Niereninsuffizienz (3)
- Oxidativer Stress (3)
- Phäochromozytom (3)
- Positronen-Emissions-Tomografie (3)
- Prevalence (3)
- SOAT1 (3)
- Sepsis (3)
- Thrombozyt (3)
- USP8 (3)
- Urämietoxine (3)
- adrenal crisis (3)
- adrenal insufficiency (3)
- adrenocortical cancer (3)
- amyloidosis (3)
- anxiety (3)
- body mass index (3)
- bone (3)
- cancer (3)
- cardiac hypertrophy (3)
- cardiology (3)
- cardiovascular disease (3)
- cognitive impairment (3)
- coronary heart disease (3)
- desmin (3)
- diet (3)
- endoradiotherapy (3)
- epidemiology (3)
- follow-up (3)
- genetics (3)
- guidelines (3)
- haemodialysis (3)
- heart rate (3)
- impact (3)
- infarction (3)
- ischemic stroke (3)
- left ventricular ejection fraction (3)
- left ventricular hypertrophy (3)
- liraglutide (3)
- lymphocytes (3)
- machine learning (3)
- magnetic resonance imaging (3)
- management (3)
- medicine (3)
- melanoma (3)
- metabolomics (3)
- mitotane (3)
- mouse (3)
- nitric oxide (3)
- osteoporosis (3)
- prognostic factors (3)
- quality of life (3)
- radial (3)
- receptor (3)
- recurrence (3)
- risk factors (3)
- safety (3)
- sepsis (3)
- uremic toxins (3)
- vandetanib (3)
- vitamin D (3)
- Adiponektin (2)
- Adrenocortical Carcinoma (2)
- Aging (2)
- Aldosteron (2)
- Aldosteronsynthaseinhibitor (2)
- Alter (2)
- Anämie (2)
- Aorta (2)
- Aortic valve stenosis (2)
- Apoptosis (2)
- Atherosclerosis (2)
- Atorvastatin (2)
- Autoantikörper (2)
- B-scan-Ultraschallkardiographie (2)
- Beschleunigungssensor (2)
- Beta-1-Rezeptor (2)
- Biomarker (2)
- C-X-C motif chemokine receptor 4 (2)
- CCR7 (2)
- CKD (2)
- CMR (2)
- CVD (2)
- CXCR7 (2)
- CYP11B2 (2)
- CYP2W1 (2)
- Catecholamine (2)
- Chemokine (2)
- Chronic kidney disease (2)
- Chronotrope Inkompetenz (2)
- Cushing-Syndrom (2)
- Cushing’s disease (2)
- DHEAS (2)
- Dilatation (2)
- Endokrinologie (2)
- Endothelial dysfunction (2)
- Endotheliale Dysfunktion (2)
- Entzündung (2)
- Enzyme replacement therapy (2)
- Eplerenone (2)
- Ezetimib (2)
- FGF-pathway (2)
- Fabry (2)
- Fabry genotype (2)
- Fabry phenotype (2)
- Fibroblast (2)
- GFAP (2)
- Germany (2)
- HFmrEF (2)
- HGF (2)
- Hepatozyten-Wachstumsfaktor (2)
- Herzdekompensation (2)
- Herzmuskelkrankheit (2)
- Herzschrittmacher (2)
- Hypertension (2)
- Immunantwort (2)
- Immunosuppression (2)
- Immunsuppression (2)
- Incidentaloma (2)
- Infarktheilung (2)
- Insulinresistenz (2)
- Inzidentalom (2)
- Kardiovaskuläre Risikofaktoren (2)
- Kidney function (2)
- Kidney transplantation (2)
- Knockout <Molekulargenetik> (2)
- Komplement <Immunologie> (2)
- Koronarangiographie (2)
- Koronarintervention (2)
- Krankheitsverlauf (2)
- Low-density-Lipoproteine (2)
- Lysosomale Speicherkrankheit (2)
- MRT (2)
- MTUS1 (2)
- Magenbypass (2)
- Magnetische Kernresonanz (2)
- Magnetresonanztomographie (2)
- Medicine (2)
- Medizin (2)
- Medullärer Schilddrüsenkrebs (2)
- Mitralinsuffizienz (2)
- Mortality (2)
- Myokardischämie (2)
- Mäuse (2)
- NAFLD (2)
- NMR-Bildgebung (2)
- NO (2)
- NT-proBNP (2)
- Nebenniereninsuffizienz (2)
- Nebennierenkrise (2)
- Nebennierenrinde (2)
- Nebennierenrindencarcinom (2)
- Nebennierenrindeninsuffizienz (2)
- Nephrologie (2)
- Nicotinamid-N-Methyltransferase (2)
- PD-L1 (2)
- PHQ-9 (2)
- PPGL (2)
- Pathogenese (2)
- Pharmakotherapie (2)
- Prognose (2)
- Prädiktoren (2)
- Punktion (2)
- QT-Zeit (2)
- Quality of life (2)
- ROS (2)
- RYGB (2)
- Rezeptor (2)
- RhoA (2)
- Rimonabant (2)
- Risikofaktor (2)
- Roux-en-Y gastric bypass surgery (2)
- SF-36 (2)
- Sarkoidose (2)
- Sensitivity (2)
- Sensitivität (2)
- Simulationstraining (2)
- Spironolacton (2)
- Stickstoffmonoxid-Synthase (2)
- Strainrate (2)
- Streptozocin (2)
- Streptozotocin (2)
- TKI (2)
- TNF-alpha (2)
- TRIB3 (2)
- Testosteron (2)
- Therapie (2)
- Thrombozytenaktivierung (2)
- Transforming Growth Factor beta (2)
- Transkatheter-Aortenklappenimplantation (2)
- Troponin (2)
- Tumor (2)
- Tyrosinkinaseinhibitor (2)
- Urämie (2)
- Vegetatives Nervensystem (2)
- Verlauf (2)
- Vitamin D (2)
- WSS (2)
- Zelllinie (2)
- [68Ga]PentixaFor (2)
- accelerometer-sensor (2)
- acute kidney injury (2)
- adenomas (2)
- adrenal cancer (2)
- adrenocortical adenoma (2)
- adrenocortical tumors (2)
- age (2)
- aging (2)
- anemia (2)
- aneurysm (2)
- antibodies (2)
- antimicrobial resistance (2)
- arrhythmia (2)
- arteriosclerosis (2)
- biocompatibility (2)
- blood (2)
- body weight (2)
- calcification (2)
- cancer treatment (2)
- carbohydrates (2)
- carcinomas (2)
- cardiac (2)
- cardiac MRI (2)
- cardiac device (2)
- cardiac magnetic resonance imaging (2)
- cardiovascular genetics (2)
- cardiovascular implantable electronic device (2)
- cardiovascular magnetic resonance (2)
- cardiovascular risk factors (2)
- catecholamines (2)
- chemokine receptor (2)
- chemotherapy (2)
- chronic cerebrovascular disease (2)
- chronotropic incompetence (2)
- comorbidity (2)
- complement system (2)
- congestive heart failure (2)
- contractility (2)
- convection volume (2)
- copeptin (2)
- coronary angiography (2)
- costs (2)
- deep learning (2)
- deformation (2)
- dementia (2)
- desmosomes (2)
- dialysis adequacy (2)
- efficacy (2)
- ejection fraction (2)
- endothelial dysfunction (2)
- endothelial nitric oxide synthase (2)
- endothelial progenitor cells (2)
- endotheliale Vorläuferzellen (2)
- erythropoietin (2)
- failure (2)
- gastric bypass (2)
- glomerular filtration rate (2)
- glycemic control (2)
- guideline adherence (2)
- hemodiafiltration (2)
- hydrocortisone (2)
- hypercholesterolemia (2)
- hyperexpression techniques (2)
- identification (2)
- immune cells (2)
- immunohistochemistry (2)
- immunotherapy (2)
- insulin resistance (2)
- internal medicine (2)
- kidneys (2)
- malnutrition (2)
- mapping (2)
- marrow (2)
- medullary thyroid carcinoma (2)
- metaanalysis (2)
- metabolism (2)
- mice (2)
- mouse models (2)
- multicenter (2)
- myocardial work (2)
- natriuretic peptide (2)
- neuroendocrine tumor (2)
- neurofilament light chain (2)
- nitric oxide synthase (2)
- oncology (2)
- outcomes (2)
- oxLDL (2)
- parathyroid hormone (2)
- pembrolizumab (2)
- peptide tyrosine tyrosine (PYY) (2)
- physical activity (2)
- placebo-controlled trial (2)
- platelets (2)
- postmenopausal women (2)
- precision medicine (2)
- primary prevention (2)
- radiotherapy (RT) (2)
- rats (2)
- regulatory T cells (2)
- remodeling (2)
- remodelling (2)
- renal function (2)
- replacement (2)
- restrictive cardiomyopathy (2)
- retrospective (2)
- rimonabant (2)
- sizing (2)
- sleeve gastrectomy (2)
- spironolactone (2)
- statins (2)
- stem cell transplantation (2)
- surgery (2)
- symptoms (2)
- telemetry (2)
- therapeutic drug monitoring (2)
- treatment (2)
- troponin (2)
- tyrosine kinase inhibitor (2)
- uremic toxin (2)
- wall shear stress (2)
- zebrafish (2)
- Überlebenszeit (2)
- 1-Methylnicotinamid (1)
- 11-beta-Hydroxylase (1)
- 2- deoxy-2-(18F)fluoro-D-glucose (1)
- 2-deoxy-2-(18F)fluoro-D-glucose (1)
- 2-dimensional speckle tracking (1)
- 2-dimensional strain (1)
- 3 T (1)
- 4D flow (1)
- 4D flow MRI (1)
- 4D-Studie (1)
- 7 T (1)
- 7T (1)
- 8p22 (1)
- <sup>18</sup>F-FDG (1)
- <sup>68</sup>Ga-Pentixafor (1)
- A-delta fibers (1)
- ACC/AHA classification (1)
- ACE-Hemmer (1)
- ACM (1)
- ACO-Schema (1)
- ACO-scheme (1)
- ADMA (1)
- ADMA/ADMA (1)
- AHF-Register Würzburg (1)
- ALT (1)
- APACHE <Klassifikation> (1)
- ARDS (acute respiratory distress syndrome) (1)
- ARVC (1)
- ASE formula (1)
- ATP generation (1)
- ATRX (1)
- AZD6140 (1)
- Acarbose (1)
- Addison's disease (1)
- Addisons disease (1)
- Adhärenz (1)
- Adipokine (1)
- Adipositaschirurgie (1)
- Adrenocortial carcinomas (1)
- Adrenocortical Cancer (1)
- Adulte Stammzelle (1)
- Advanced Adrenocortical Carcinoma (1)
- African-americans (1)
- Agalsidase beta (1)
- Aktionspotenzial (1)
- Akzeptanz (1)
- Albumin (1)
- Aldosteron Antagonisten (1)
- Aldosteronantagonist (1)
- Aldosterone (1)
- Aldosterone Antagonists (1)
- Allelische Verlustanalyse (1)
- Alpha-Galactosidase (1)
- Alpha-galactosidase (1)
- Altern (1)
- Alternans (1)
- Alveolarmakrophagen (1)
- Alzheimer’s dementia (1)
- Amyloidose (1)
- Anaplastisches Schilddrüsenkarzinom (1)
- Angiogenese (1)
- Angiotensin (1)
- Angst (1)
- Antigen 4 (1)
- Antikörper (1)
- Aortenklappe (1)
- Aortic arch (1)
- Aortic valve replacement (1)
- Aortokoronarer Bypass (1)
- Apherese (1)
- Aplastic anemia (1)
- ApoE-Knock-Out-Maus (1)
- ApoE-knock-out mice (1)
- ApoE/eNOS dko-Mäuse (1)
- Apoptose (1)
- Arrhythmie (1)
- Arterielle Gefäßsteifigkeit (1)
- Arteriosclerosis (1)
- Artificial Nuclear Pores (1)
- AsP (1)
- Ataciguat (1)
- Atemvariabilität (1)
- Atorvastatins (1)
- Atrioventrikuläre Verzögerung (1)
- Aufmerksamkeit (1)
- Augenoberfläche (1)
- Ausdehnung (1)
- Autoimmune-Diseases (1)
- Autophagie (1)
- B (1)
- B cells (1)
- B-Zelle (1)
- BALF (1)
- BET Inhibitor (1)
- BIRC7 (1)
- BNP (1)
- BRAF mutation (1)
- BRAF(V600E) mutation (1)
- BRD4 (1)
- Basischarakteristika (1)
- Befund (1)
- Berliner Blau (1)
- Beru (1)
- Bestimmung der hochgradigen Mitralklappeninsuffizienz (1)
- Bestrahlung (1)
- Betablocker (1)
- Betriebsmedizin (1)
- Bildgebung (1)
- Biochemical-Diagnosis (1)
- Bioimpedanz (1)
- Biokompatibilität (1)
- Bioluminescence (1)
- Blind Pericardiocentesis (1)
- Blinde Perikardiozentese (1)
- Blutflussrate (1)
- Bluthochdruck (1)
- Blutstammzelle (1)
- Blutzelle (1)
- Blutzuckerverlauf (1)
- Body-Mass-Index (1)
- Bodyplethysmographie (1)
- Brain atrophy (1)
- Brain natriuretic Peptide (1)
- Braune Fettzelle (1)
- Brownian ratchet (1)
- Brustaorta (1)
- C-C Chemokinrezeptor 7 (1)
- C-reaktives Protein (1)
- C3 (1)
- C57/Bl6 (1)
- CASP (1)
- CD16 (1)
- CD32 (1)
- CD4+ T-cells (1)
- CD9 (1)
- CIED malfunction; pacemaker (PM) (1)
- CK-knockout Maus (1)
- CML (1)
- COH29 (1)
- COPD (1)
- COPD diagnosis (1)
- COVID‐19 vaccination (1)
- CRH stimulation test (1)
- CRISPR/Cas-Methode (1)
- CRP (1)
- CRP/crp (1)
- CRT (1)
- CT-scan (1)
- CTNNB1 (1)
- CYP11A1 (1)
- CYP11B1 (1)
- CYP2B6 (1)
- Ca cycling (1)
- Ca2+i handling (1)
- Calcineurin-NFATsignaling (1)
- Calcium (1)
- Calcium Citrate (1)
- Calcium-Aufnahme (1)
- Calibration (1)
- Cancer genetics (1)
- Cannabionoid-1-Rezeptorantagonist (1)
- Cardiac Antigens (1)
- Cardiac magnetic resonance imaging (1)
- Cardiac resynchronization therapy defibrillator (1)
- CardioMEMS™ HF-System (1)
- Cardiomyopathy (1)
- Cardiovascular Riskfactors (1)
- Cardiovascular diseases (1)
- Cardiovascular hospitalizations (1)
- Cardiovascular risk factors (1)
- Cardiovascular risk prediction (1)
- Carotid intima-media thickness (CIMT) (1)
- Carotid segment (1)
- Carotid ultrasound (1)
- Catheter Lock Solution (1)
- Catheter-related Bloodstream Infections (CRBSI) (1)
- Cell lung canger (1)
- Chemokinrezeptor (1)
- Chemokinrezpetor (1)
- Chirodiagnostik (1)
- Cholesterin (1)
- Cholesterin-Umtake (1)
- Cholesterinstoffwechsel (1)
- Cholesterol metabolism (1)
- Chromosom 8 (1)
- Chromosomenanalyse (1)
- Chronic Kidney-disease (1)
- Chronic heart failure (1)
- Chronic heart-failure (1)
- Chronic kidney-disease (1)
- Chronische Nierenerkrankung (1)
- Ciclosporin (1)
- Cine (1)
- Clinical prediction rule (1)
- Clinical proteomics (1)
- Clinical trial (1)
- Clinical-trials (1)
- Clodronsäure (1)
- Clopidogrel (1)
- Cognitive decline (1)
- Cohort study (1)
- Complement (1)
- Computer-aided therapy (1)
- Computergestützte Medizin (1)
- Computertomografie (1)
- Contact-to-balloon (1)
- Contemplative Meditation and Breathing Techniques (CMBT) (1)
- Contrast agent (1)
- Contrast-enhanced CT (1)
- Copeptin (1)
- Coronavirus Disease 2019 (1)
- Cortisol (1)
- Cumulative incidence function (1)
- Cushing syndrome (1)
- Cushing's (1)
- Cushing's disease (1)
- Cushings syndrome (1)
- Cyclo-GMP (1)
- Cystatin C (1)
- Cytokine (1)
- Cytoskeleton (1)
- DCAF17 (1)
- DCM (1)
- DF-Testung (1)
- DFT (1)
- DHEA-Sulfotransferase (1)
- DIA-MS (1)
- DNA damage (1)
- DOTATOC (1)
- DSC2 (1)
- DSG2 (1)
- Deceased Donor Score (1)
- Demenz (1)
- Dendritic Cells (1)
- Dephasing (1)
- Depression treatment (1)
- Depressive symptomatology (1)
- Desmoplakin (1)
- Deutsches Zentrum für Herzinsuffizienz Würzburg (1)
- Deutschland (1)
- Deutschland / Bundeswehr (1)
- Diabetes mellitus Typ 2 (1)
- Diabetes mellitusTyp 1 (1)
- Diabetes melltius (1)
- Diabetic nephropathies (1)
- Diabetic-nephropathy (1)
- Diabetische Nephropathie (1)
- Diagnosis (1)
- Diagnostik (1)
- Diagnostik / Bildgebendes Verfahren (1)
- Dialysatorleistung (1)
- Dialysemembran (1)
- Diastocic Dysfunction (1)
- Dickdarmkrebs (1)
- Dickenmessung (1)
- Differenzierung (1)
- Dihydroethidium (1)
- Dilated Cardiomyopathy (1)
- Dimension 3 (1)
- Dimethylarginin <N (1)
- Dipeptidyl-peptidase IV inhibitors (1)
- Discovery (1)
- Disease prevalence (1)
- Diversity (1)
- Dobutamin-Stress-Echokardiographie (1)
- Dokumentationsqualität (1)
- Donor-Score (1)
- Dosierungen von Herzinsuffizienzmedikamenten (1)
- Draisine <Zweirad> (1)
- Drotrecogin alpha (1)
- Drug-eluting Stent (1)
- Dumping Syndrom (1)
- Dumping-Syndrome (1)
- E/e’ (1)
- E193 (1)
- ECG-gated (1)
- EMT (1)
- EP Procedures (1)
- EPC (1)
- EQUAL-Pilotstudie (1)
- ERCC1 (1)
- ERCC1 Chemotherapie Nebennierenrindenkarzinom (1)
- ERI (1)
- ESC (1)
- ESC Score (1)
- ETB-Rezeptor (1)
- ETB-receptor (1)
- ETiCS (1)
- EUROASPIRE (1)
- Echtes WRF (1)
- Einflussfaktoren (1)
- Eisenmangel (1)
- Elastizität (1)
- Elektrophysiologie (1)
- Elektrophysiologische Untersuchung (1)
- Elektrostimulation (1)
- Embolie (1)
- Empathie (1)
- End-of-Life Care (1)
- End-of-Life Decision (1)
- Enddiastolisches Volumen (1)
- Endocannabinoide (1)
- Endocrinology (1)
- Endogenes Erythropoietin und Mortalität (1)
- Endogenous erythropoietin and all-cause mortality (1)
- Endokrine Onkologie (1)
- Endothelaktivierung (1)
- Endotheldysfunction (1)
- Endothelin (1)
- Endothelzelle (1)
- Endothelzellen (1)
- Entscheidungsunterstützungssystem (1)
- Enzym-Ersatz-Therapie (1)
- Enzymersatztherapie (1)
- Enzyminhibitor (1)
- Enzyminhibitoren (1)
- Epidemiology (1)
- Eplerenon (1)
- Epoetin beta (1)
- Erblichkeit (1)
- Ergospirometrie (1)
- Erlotinib (1)
- Ernährungs- und Bewegungstherapie (1)
- Ersatzstoff (1)
- Erwartungshaltung (1)
- Etomidat (1)
- European Society (1)
- Euroscore (1)
- Exchange Stabilization Fund (1)
- Expression (1)
- Extracellular volume (1)
- Extracorporeal membrane oxygenation (1)
- Extrakorporale Dialyse (1)
- Eya4 (1)
- Ezetimibe (1)
- F-18-FDG PET/CT (1)
- FACS (1)
- FACS-Flow-Analysen (1)
- FGF21 (1)
- FGFR-inhibitors (1)
- Fabry Disease (FD) (1)
- Fabry Kardiomyopathie (1)
- Fabry Stabilization Index (1)
- Fabry's disease (1)
- Fabry-Kardiomyopathie (1)
- Fabry-Nephropathie (1)
- False positive reactions (1)
- Family Investigation of Nephropathy and Diabetes (1)
- Fehlerverhütung (1)
- Female patients (1)
- Femoralarterienplaque (1)
- Femoralplaque (1)
- Fettgewebe (1)
- Fettmassenanteil (1)
- Fettzelle (1)
- Fetuin-A (1)
- FiTT-STEMI (1)
- Fibroblast Growth Factor-21 (1)
- Fibroblast-Growth-Factor-23 (1)
- Fibroblastenwachstumsfaktor (1)
- Fibronectin (1)
- Fibrozyt (1)
- Fliegendes Personal (1)
- Fliegerarzt (1)
- FoxP3 Expression (1)
- Foxp3 (1)
- Foxp3+CD4+ regulatorische T-Zelle (1)
- Fractalkine (1)
- Framingham (1)
- Freie Fettsäuren (1)
- Friedreich-Ataxie (1)
- G protein coupled receptors (1)
- GFR (1)
- GH response (1)
- GLP-1 (1)
- GMPcGMP-dependent protein kinase I (1)
- GOLD (1)
- GP IIb/IIIa Rezeptor-Antagonist (1)
- GP IIb/IIIa inhibitor (1)
- GRAPPA (1)
- Galactosidase-A gene (1)
- Game (1)
- Gastric-banding (1)
- Gb3 and lyso-Gb3 biomarkers (1)
- General-population (1)
- Genexpression (1)
- Genome-wide association studies (1)
- Geriatrie (1)
- Gering differenziertes Schilddrüsenkarzinom (1)
- Geschlechtsunterschied (1)
- Glial fibrillary acidic protein (1)
- Globotriaosylceramide (1)
- Glomerular-filtration-rate (1)
- Gluconeogenese (1)
- Gluconeogenesis (1)
- Glucosephosphatdehydrogenase (1)
- Glucosestoffwechsel (1)
- Glukoseaufnahme (1)
- Glukoseeffektivität (1)
- Glukosestoffwechsel (1)
- Glut4 (1)
- Glutathion (1)
- Glycaemic control (1)
- Graves disease (1)
- Grundlagenforschung (1)
- Guanylyl cyclase (1)
- HAT (1)
- HCM (1)
- HD (1)
- HDF (1)
- HEK cells (1)
- HFpEF (1)
- HFrEF (1)
- HIV (1)
- HIV diagnosis and management (1)
- HLA (1)
- HMR1766 (1)
- HMW-Adiponektin (1)
- HPLC (1)
- HPLC-MS (1)
- HSD3B2 (1)
- HUVEC (1)
- HUVEC Zellen (1)
- Hausarzt (1)
- Haut (1)
- Hazards (1)
- Healthcare research (1)
- Heart (1)
- Heart attack (1)
- Heeresfliegertruppe (1)
- Hematopoietic cell transplant (1)
- Hemodialysis-patients (1)
- Hemoglobin A1C (1)
- Hepcidin (1)
- Herz (1)
- Herzbeutel (1)
- Herzerweiterung (1)
- Herzfrequenzvariabilität (1)
- Herzfunktion (1)
- Herzklappenfehler (1)
- Herzmuskelzelle (1)
- Herzrhythmusstörungen (1)
- HiGHmed (1)
- High risk prostate cancer (1)
- Hochrisiko Prostatakarzinom (1)
- Home monitoring (1)
- Homoarginin/homoarginine (1)
- Hormon (1)
- Hubschrauber (1)
- Hubschrauberpilot (1)
- Humangenetik (1)
- Hydroxysteroid-Sulfotransferase (1)
- Hyperaldosteronismus (1)
- Hyperandrogenämie (1)
- Hypercholesterinämie (1)
- Hypercortisolism (1)
- Hyperglykämie (1)
- Hyperkalemia (1)
- Hyperosmotic Stress (1)
- Hyperoxidion (1)
- Hyperoxidion Dihydroethidine (1)
- Hypertrophische Herzmuskelkrankheit (1)
- Hypoadrenalismus (1)
- Hypoglycemia (1)
- Hypoglykämie (1)
- Hyponatriämie (1)
- Hämodiafiltration (1)
- Hämodynamik (1)
- IDH1/2 (1)
- IGF-1 (1)
- IGF-I (1)
- IMAZA (1)
- IP3 (1)
- IP3-Signaling (1)
- Idiopathische pulmonale Fibrose (1)
- Immun-Checkpoint (1)
- Immunassay (1)
- Immuncheckpointinhibitor (1)
- Immune-System (1)
- Immunoassay (1)
- Immunological Self-Tolerance (1)
- Immunseneszenz (1)
- Immunsystem (1)
- Immuntherapie (1)
- Impella (1)
- Implantierbare Kardioverter Defibrillatoren (1)
- Index-Hospitalisierung (1)
- Indoxylsulfat (1)
- Infarkt (1)
- Infarktausdehnung (1)
- Infarktdicke (1)
- Infarktvolumen (1)
- Infection control (1)
- Instant (1)
- Insulin therapy (1)
- Insulin-like Growth Factor I (1)
- Intensive Care (1)
- Intensivmedizin (1)
- Intensivtransport (1)
- Interhospitaltransfer (1)
- Interkonversion (1)
- Interleukin-6 (1)
- Internet of Things devices (1)
- Interviews (1)
- Ionenstärke (1)
- Ionisierende Strahlung (1)
- JQ1 (1)
- Jugendliche (1)
- Juvenile biventricular cardiomyopathy (1)
- KDIGO (1)
- KHK (1)
- KWIC (1)
- Kalzifikation (1)
- Kammerflimmern (1)
- Kaposi sarcoma (1)
- Kardiale Phasenkontrast-MRT (1)
- Kardiale Resynchronisationstherapie (1)
- Kardinale Antigene (1)
- Kardio-CT (1)
- Kardiomyozyt (1)
- Kardiomyozyten (1)
- Kardiovaskuläre Krankheit (1)
- Karotisarterienplaque (1)
- Karotisplaque (1)
- Kathetersepsis (1)
- Katheterthrombose (1)
- Kernspinrelaxation (1)
- Kinder (1)
- Kleinzelliges Bronchialkarzinom (1)
- Klinische Symptomatik (1)
- Klinisches Experiment (1)
- Klotho-related molecules (1)
- Knochenmarkzelle (1)
- Knochenmetastasen (1)
- Knock-Out <Druckschrift> (1)
- Knockdown (1)
- Kognition (1)
- Kohortenstudie (1)
- Kollagen (1)
- Kollagendefekt (1)
- Kolon (1)
- Kolonkarzinogenese (1)
- Kombination EKG-Kriterien (1)
- Komorbiditäten (1)
- Komorbiditäten bei Nebenniereninsuffizienz (1)
- Komplement (1)
- Komplikationen (1)
- Kontraktilität (1)
- Kontrastmittel (1)
- Kontrollierte klinische Studie (1)
- Koronararterie (1)
- Koronarographie (1)
- Kosten (1)
- Kraniopharyngiom (1)
- Krankheit (1)
- Kreatinin (1)
- Kreatinkinase (1)
- Kreuzschmerz (1)
- Körperliche Leistungsfähigkeit (1)
- L-Arginin Paradox (1)
- LC/MS (1)
- LCA (1)
- LCNEC (1)
- LDL (1)
- LDL cholesterol (1)
- LMNA (1)
- LND (1)
- LNE (1)
- LOH (1)
- LV dilatation (1)
- LVNC (1)
- Lag time (1)
- Langfristige Prognose (1)
- Langzeit-Follow-up (1)
- Langzeitbeatmung (1)
- Langzeitprognose (1)
- Langzeitüberleben (1)
- Late Enhancement (1)
- Lebensqualitaet (1)
- Lebensqualitätsfragebögen (1)
- Lebensstilintervention (1)
- Leber (1)
- Left ventricular function (1)
- Left ventricular hypertrophy (1)
- Lehre (1)
- Leptine (1)
- Leukozyt (1)
- Leukozyten-Endothelzell-Interaktionen (1)
- Linagliptin (1)
- Line of Perpendicularity (1)
- Linke Herzkammer (1)
- Linksherzstimulation (1)
- Linksschenkelblock (1)
- Linksventrikuläre Funktion (1)
- Linksventrikuläre Hypertrophie (1)
- Linksventrikuläre Masse (1)
- Lipolyse (1)
- Lipoproteinapherese (1)
- Lipoxygenase <5-> (1)
- Long COVID (1)
- Loop recorder (1)
- Loss of heterozygosity (1)
- Low-Gradient Aortenklappenstenose (1)
- Lungenfibroblasten (1)
- Lungenfunktionsdiagnostik (1)
- Lungenfunktionsprüfung (1)
- Lycopin (1)
- Lymphoceles (1)
- Lymphozelen (1)
- Lyso Gb3 (1)
- Lyso-GB3 (1)
- MAPSE (1)
- MASS (1)
- MCP-1 (1)
- MEN1 (1)
- MMP (1)
- MMP-9 (1)
- MOLLI (1)
- MR (1)
- MR guidance (1)
- MRP-1 (1)
- MTC (1)
- MTUS1-Gen (1)
- MUST-Score (1)
- MUTYH1 (1)
- Macrophages (1)
- Magnetic Resonance Imaging (1)
- Magnetic resonance imaging (1)
- Magnetische Resonanz (1)
- Makroalbuminuriker (1)
- Makrophage (1)
- Makrophagen (1)
- Mangelernährung (1)
- Markumar (1)
- Mass-spectrometry (1)
- Matrix-Gla-Protein (1)
- Maus <Gattung> (1)
- Maus-Lungen-Fibroblasten (1)
- Measurement (1)
- Medulläres Schilddrüsenkarzinom (1)
- Membranöse Glomerulonephritis (1)
- Memory dysfunction (1)
- Men (1)
- Metabolisches Syndrom (1)
- Metabolismus (1)
- Metabolom (1)
- Metabolome (1)
- Metabolomics (1)
- Metabolomik (1)
- Metanephrin (1)
- Metanephrine (1)
- Methicillin-resistant staphylococcus aureus (1)
- Methodological quality (1)
- Metomidat (1)
- Metoprolol (1)
- Mfn2 KO mice (1)
- Mice (1)
- Mikroarray (1)
- Mikrozirkulation (1)
- Mineralkortikoidrezeptor-Blockade (1)
- Mitochondrium (1)
- Mitofusin2 (1)
- Mitotane (1)
- Mitotane Nebennierenkarzinom (1)
- Mitraclip (1)
- Mitral regurgitation (1)
- Mitralklappe (1)
- Mitralklappenfehler (1)
- Mitralklappeninsuffizienz (1)
- Mitralklappenringbewegung (1)
- Mitralklappenvitium (1)
- Mittelgradige Aortenklappenstenose (1)
- Model (1)
- Molecular Channel Transport (1)
- Molekulargenetik (1)
- Molekül (1)
- Monocytes (1)
- Monozyt (1)
- Monozyten-Makrophagen-System (1)
- Morbidity (1)
- Morbidität (1)
- Morbus Cushing (1)
- Mortalität (1)
- Mouse (1)
- Mouse models (1)
- Multidrug Resistance Protein-1 (1)
- Multiparameter predictor (1)
- Multiple-Sclerosis (1)
- Multiples Myelom (1)
- Muscle (1)
- Muskel (1)
- Muskelfasertypen (1)
- Mutation (1)
- Mycardiale Heilung (1)
- Mycophenolate mofetil (1)
- Mycophenolatmofetil (1)
- Myeloma (1)
- Myocardial Healing (1)
- Myocardial Infarction (1)
- Myocardial ischemia (1)
- Myocardial-Infarction (1)
- Myocardium (1)
- Myokard (1)
- Myokardiales Remodeling (1)
- Myokardifarktmodell (1)
- Myosin (1)
- Myosin-Schwerkette (1)
- N-> (1)
- NASH (1)
- NCI-H295 Zellen (1)
- NCI-H295R (1)
- NEC (1)
- NET (1)
- NMR-Tomography (1)
- NMR-tomography (1)
- NO-Bioverfügbarkeit (1)
- NO-Synthase (1)
- NO/cGMP pathway (1)
- NO/cGMP-Signalkaskade (1)
- NOP10 (1)
- NOX (1)
- NR3C1 (1)
- NSG animals (1)
- Nahrung (1)
- Natrium-23 (1)
- Natriumkanal (1)
- Natriumkonsum (1)
- Natural-history data (1)
- Navigation (1)
- Nebenenniereninsuffizienz (1)
- Nebennierengewebe (1)
- Nebenniereninzidentalom (1)
- Nebennierenkrankheit (1)
- Nebennierenkrisen Addison Krise (1)
- Nebenwirkungen (1)
- Nebivolol (1)
- Nephropathie (1)
- Nephrotisches Syndrom (1)
- Neprilysin inhibition (1)
- Network (1)
- Netzwerk (1)
- Neurokognitive Funktion (1)
- Neurons (1)
- New mexico (1)
- NfL (1)
- Nicht-kleinzelliges Bronchialkarzinom (1)
- Nierenversagen (1)
- Nitric oxide (1)
- Non-Compaction Kardiomyopathie (1)
- Non‐ischaemic cardiogenic shock (1)
- Normetanephrin (1)
- Normetanephrine (1)
- Normierung (1)
- Notfall (1)
- Nrf2 (1)
- OAT1 (1)
- OAT3 (1)
- OK cells (1)
- ORO (1)
- OSI (1)
- OXPHOS (1)
- Obesity (1)
- Observational study (1)
- Obstruktive Ventilationsstörung (1)
- Oil-Red-O (1)
- Onkologie (1)
- Onset hypertrophic cardiomyopathy (1)
- Oral antidiabetic drugs (1)
- Organversagen (1)
- Oscillation of QT interval (1)
- Osteogenesis imperfecta (1)
- Oszillationen der QT-Zeit (1)
- Outcome survey (1)
- Outcomes (1)
- OxLDL (1)
- P-cresyl sulfate (1)
- P2Y12-Rezeptor (1)
- P2Y12-receptor (1)
- P450scc (1)
- PAPSS2 (1)
- PBMC (1)
- PCR (1)
- PET-Tracer (1)
- PF-05231023 (1)
- PHQ-2 (1)
- PLC (1)
- PRO (1)
- PTA (1)
- PWV (1)
- PYY3-36 (1)
- Pain-related evoked potentials (1)
- Palmitinsäure (1)
- Palmoplantar keratoderma (1)
- Pankreatisches Polypeptid (1)
- Paragangliom (1)
- Paraganglioma (1)
- Parathormon (1)
- Paricalcitol (1)
- Patientencharakteristika (1)
- Patientenperspektiven (1)
- Patientenschulungen (1)
- Patientenzufriedenheit (1)
- Pedometer (1)
- Pentaerythrityltetranitrat (1)
- Performance (1)
- Pericardium (1)
- Perikard (1)
- Perikarderguss (1)
- Perikardiozentese (1)
- Perikardpunktion (1)
- Perikardtamponade (1)
- Perkutane transluminale koronare Angioplastie (1)
- Perspektivenübernahme (1)
- Perspektivwechsel (1)
- Phosphoadenosinphosphosulfat (1)
- Phosphodiesterasehemmer (1)
- Plaque (1)
- Plasma (1)
- Plasmametanephrine (1)
- Platin (1)
- Plötzlicher Herztod (1)
- Popdc (1)
- Positron-emission-tomography (1)
- Postischämiesyndrom (1)
- Postmarketing Experience (1)
- Postoperative Hypoglykämie (1)
- Predictive value of tests (1)
- Predictors (1)
- Preserved Ejection Fraction (1)
- Primary care (1)
- Primärer Hyperaldosteronismus (1)
- Probabilities (1)
- Prognose Nebennierenrindenkarzinom (1)
- Prognosefaktoren (1)
- Prognostic Factors ACC (1)
- Prognostic impact (1)
- Progression (1)
- Progressionsverzögerung (1)
- Prokollagen (1)
- Proliferation (1)
- Pronosefaktoren Nebennierentumor (1)
- Protein (1)
- Protein C (1)
- Protein p8 (1)
- Protein-Tyrosin-Kinasen (1)
- Proteinmangel (1)
- Proteinurie (1)
- Prussian Blue (1)
- Prädilutions-Hämodiafiltration (1)
- Prävalenz (1)
- Prävention (1)
- Pseudo-WRF (1)
- Psychopharmakologie (1)
- Psychotherapie (1)
- Pulmonologie (1)
- Pulswelle (1)
- QT intervall dispersion (1)
- QT-Dispersion (1)
- QT-Zeit Verlängerung (1)
- Qualitative Content Analysis (1)
- Qualitative Inhaltsanalyse (1)
- RAKI (1)
- RANTES (1)
- RCA (1)
- RNA Expression (1)
- RNAScope (1)
- RNR (1)
- RRM2 (1)
- Racial differences (1)
- Radiation (1)
- Radiochemotherapie (1)
- Radiochirurgie (1)
- Raman micro-spectroscopy (1)
- Ramipril (1)
- Rat (1)
- Reactive Oxygen Species (1)
- Reaktive Sauerstoffspezies (1)
- Rebreathing (1)
- Rechtsventrikuläre Thrombusbildung (1)
- Recognition of depression (1)
- Redox-Stoffwechsel (1)
- Reduktion der Mortalität (1)
- Referenzperzentile (1)
- Register (1)
- Registry (1)
- Regression (1)
- Regulatorische T-Lymphozyt (1)
- Rekrutierung (1)
- Rekrutierungsstrategien (1)
- Remote device monitoring (1)
- Renin-Angiotensin-Aldosteron System (1)
- Renin-Angiotensin-System (1)
- Renin-angiotensin System (1)
- Reoperation (1)
- Research design (1)
- Resistance (1)
- Rezeptorblocker (1)
- Rezidiv (1)
- Rheumatischer Formenkreis (1)
- Rheumatismus (1)
- Rho-kinase (1)
- Right ventricular dysfunction (1)
- Ringmotion (1)
- Risikostratifizierung (1)
- Risk (1)
- Risk-factors (1)
- Rosiglitazon (1)
- Rosuvastatin (1)
- Roux-en-Y Gastric Bypass (1)
- Roux-en-Y gastric bypass (1)
- Rückatmungsmethode (1)
- Rückenschmerz (1)
- SARS‐CoV‐2 infection (1)
- SASHA (1)
- SB 239063 (1)
- SBRT (1)
- SCD-Risko nach PTSMA (1)
- SCORE (1)
- SDMA (1)
- SDMA/SDMA (1)
- SF-36 Health survey (1)
- SF-36 questionnaire (1)
- SG (1)
- SGLT2 inhibitor (1)
- SGLT2 inhibitors (1)
- SNP (1)
- SOAT (1)
- SOAT Inhibitoren (1)
- SR Ca leak (1)
- SR/Mitochondriales Feedback (1)
- SR/mitochondria metabolic feedback (1)
- SREBP-2 (1)
- SSTR (1)
- ST-elevation myocardial infarction (1)
- STEMI (1)
- STIM2 (1)
- SULT2A1 (1)
- SUMO2 (1)
- Salz (1)
- Sample-sizes (1)
- Sarkomer (1)
- Sars-CoV-2 (1)
- Schaf (1)
- Schenkelblock (1)
- Schilddrüsenkrebs (1)
- Schlaganfall (1)
- Schlauchmagen (1)
- Schockeffektivität (1)
- Schocktestung (1)
- Schold-Score (1)
- Schrittzähler (1)
- Schwanmessmethode (1)
- Sechs-Minuten-Gehstrecke (1)
- Sekundenherztod (1)
- Sekundärkrankheit (1)
- Selbsterfahrung (1)
- Self-navigation (1)
- Septal bulge (1)
- Septischer Schock (1)
- Serinproteinasen (1)
- Severe Acute Respiratory Syndrome Coronavirus 2 (1)
- Sex-Hormones (1)
- ShMOLLI (1)
- Sham (1)
- Short-term-Variabilität (1)
- Signaltransduktion (1)
- Sildenafil (1)
- Simulator (1)
- Simvastatin (1)
- Skeletal-related events (1)
- Skin (1)
- Small fiber neuropathy (1)
- Society (1)
- Sodiumchannel (1)
- Somatische Mutation (1)
- Speckle Tracking (1)
- Speckle tracking (1)
- Spin echo (1)
- Spirituell-ganzheitliche Behandlung (1)
- Spiroergometrie (1)
- Sport (1)
- Sportart (1)
- Sportliche Bewegung (1)
- Stage renal-disease (1)
- Statine (1)
- Stein-Leventhal-Syndrom (1)
- Stemi (1)
- Stent (1)
- Stereotaktische Strahlentherapie (1)
- Steroide (1)
- Steroidogenese (1)
- Steroidstoffwechsel (1)
- Sterol O-Acyltransferasen (1)
- Sterol-O-Acyl transferases (1)
- Stickstoffoxidsynthase (1)
- Stiffness (1)
- Strahlenfibrose (1)
- Strain (1)
- Strain Rate Imaging (1)
- Strain-Rate (1)
- Subdistribution (1)
- Subjektive Krankheitswahrnehmung (1)
- Sudden death (1)
- Sudden death Risk after PTSMA (1)
- Sunitinib (1)
- Superoxidanion (1)
- Superoxidanionen (1)
- Suppressive Function (1)
- Surrogat (1)
- Survival (1)
- Symptom (1)
- Symptome (1)
- Systemic-Lupus-Erythematosus (1)
- Systole (1)
- T cells (1)
- T-Cell Specificity (1)
- T-Lymphocytes (1)
- T-Lymphozyt (1)
- T-Lymphozyten (1)
- T-Zell Spezifität (1)
- T-cells (1)
- T1 mapping (1)
- T1rho (1)
- T1ρ (1)
- TERT (1)
- TGF beta (1)
- TGF-beta antibody (1)
- THP-1- cells (1)
- THP-1-Zellen (1)
- TIMP (1)
- TIMP-1 (1)
- TIP39 (1)
- TRB3 (1)
- TTE (1)
- TT\(_{1rho}\) mapping (1)
- TVI (1)
- T\(_{1P}\) dispersion (1)
- T\(_{1P}\) mapping (1)
- Tandem-Massenspektrometrie (1)
- Tanzania (1)
- Targeted Metabolomics (1)
- Taurolidine (1)
- Teichholz formula (1)
- Teicholz-Formel (1)
- Telemetrie (1)
- Test accuracy (1)
- Testosteronreductase <Testosteron-5-alpha-Reductase> (1)
- Testosteronstoffwechsel (1)
- Tests (1)
- Thalidomid (1)
- The L-arginine Paradox (1)
- Therapieadhärenz (1)
- Therapiebegrenzung (1)
- Therapiezieländerung (1)
- Thermodynamics (1)
- Thermodynamik (1)
- Thrombi (1)
- Thrombozyten (1)
- Thrombozyten-Aktivierung (1)
- Thrombus (1)
- Thymus (1)
- Tiermodell (1)
- Time measurement (1)
- Time-motion-Ultraschallkardiographie (1)
- Tirofiban (1)
- Transforming Growth Factor beta 1 (1)
- Transkription <Genetik> (1)
- Transplantatfunktion (1)
- Transport (1)
- Transporthubschrauberregiment 30 (1)
- Treatment outcome (1)
- Tregs (regulatory T cells) (1)
- Tumor-Nekrose-Faktor (1)
- Tumorsuppressor-Gen (1)
- Tumorsuppressorgen (1)
- Tumosuppresorgen (1)
- Typ 2-Diabetes (1)
- Typ-1-Diabetes (1)
- Typ-2-Diabetes-mellitus (1)
- Tyrosinkinase (1)
- USP28 (1)
- USP48 (1)
- Ultrahochfeldmagnetresonanztomographie (1)
- Ultraschall (1)
- Ultraschallgeführte Biopsie (1)
- Ultraschallgesteuert (1)
- Ultraschallkar (1)
- Ultraschallkardiografie (1)
- United States (1)
- Utility (1)
- VAS (1)
- VEMP (1)
- Valvular heart-desease (1)
- Vapreda (1)
- Variants (1)
- Vaskuläre Funktion (1)
- Vasokonstriktion (1)
- Vasoreaktivitäsmessung (1)
- Ventricular Remodeling (1)
- Ventricular septal rupture (1)
- Ventrikelruptur (1)
- Ventrikuläres Remodeling (1)
- Verdachtsüberprüfung (1)
- Verhalten (1)
- Verlaufsbeobachtung (1)
- Verringerung (1)
- Verträglichkeit der Enzymersatztherapie (1)
- Virtual-Reality (1)
- Virtual-reality (1)
- Virtuelle Realitaet (1)
- Virtuelle Realität (1)
- Vitamin-D-Mangel (1)
- Volumenmessung (1)
- Vorderwandinfarkt (1)
- Vordilatation (1)
- Vorhofflimmern (1)
- Vorhofkatheter (1)
- Wachstumshormonbehandlung (1)
- Wandschubspannung (1)
- Weaning (1)
- Weiße Fettzelle (1)
- Wistar-Ratte (1)
- Wistar-Ratten (1)
- Woodhouse-Sakati Syndrom (1)
- Woodhouse-Sakati sydrome (1)
- Workshop Neue Aspekte zur Linksventrikulären Dysfunktion (1992 : Erbach, Rheingau) (1)
- Wound Healing (1)
- Wundheilung (1)
- Wärmebildkamera (1)
- X-chromosomal inactivation (1)
- XA (1)
- Young-patients (1)
- ZDF rats (1)
- Zebrabärbling (1)
- Zebrafisch (1)
- Zentrale Toleranz (1)
- Zetrales Cushing Syndrom (1)
- Zucker fatty fa/fa rats (1)
- Zweitlinientherapie (1)
- [177Lu]/[90Y]PentixaTher (1)
- [177Lu]PentixaTher (1)
- [18F]FDG-PET-CT (1)
- [90Y]PentixaTher (1)
- [\(^{68}\)Ga] pentixafor (1)
- \(^{18}\)F-FDG (1)
- \(^{18}\)F-fluorodeoxyglucose (1)
- abdominal lymph node metastases (1)
- ablation (1)
- absorption (1)
- accelerated atherosclerosis (1)
- activated protein C (1)
- activated-receptor gamma (1)
- activation (1)
- acute (1)
- acute respiratory distress syndrome (1)
- adaptive immune response (1)
- add-on (1)
- adenovirus (1)
- adenoviruses (1)
- adenylyl cyclase signaling cascade (1)
- adherence (1)
- adiponectin (1)
- adjuvant platinum-based chemotherapy (1)
- adjuvant therapy (1)
- adjuvant treatment (1)
- adrenal cortical carcinoma (1)
- adrenal gland (1)
- adrenal glands (1)
- adrenal incidentaloma (1)
- adrenal tumor (1)
- adrenal tumors (1)
- adrenal tumours (1)
- adrenale Steroidogenese (1)
- adrenalectomia (1)
- adrenocortical adenocarcinoma (1)
- adrenocortical carcinoma (ACC) (1)
- adrenocortical cell line (1)
- adrenocortical development (1)
- adrenocortical tissues (1)
- adrenocortical tumor (1)
- adrenokortikale Zellen (1)
- adrenokortikales Karzinom (1)
- adult patients (1)
- adverse effects (1)
- afatinib (1)
- agnoists (1)
- aircrew (1)
- akute Niereninsuffizienz (1)
- akutes Nierenversagen (1)
- albumin (1)
- albumin excretion rate (1)
- albuminuria (1)
- alcohol (1)
- aldosterone (1)
- allocation (1)
- allogeneic hematopoietic stem cell transplantation (1)
- alpha -Galaktosidase (1)
- alpha- Galactosidase (1)
- alpha/delta agonist GFT505 (1)
- amphiphilic block copolymer (1)
- anaemia (1)
- anatomy (1)
- animal model (1)
- animal models of human disease (1)
- antagonist (1)
- anti-drug antibodies (1)
- anti-myocardial (1)
- antibiotic prescription (1)
- anticoagulation (1)
- antidiabetic agents (1)
- antimicrobial stewardship (1)
- antiphospholipid syndrome (1)
- antiretroviral therapy (1)
- antiretrovirals (1)
- anti‐SARS‐CoV‐2‐spike IgG (1)
- aorta (1)
- aortic arch (1)
- aortic stenosis (1)
- aortic valve disease percutaneous intervention (AVDP) (1)
- aortic valve stenosis (1)
- aortic valve stenosis (AS) (1)
- apoE-Knockout Maus (1)
- apoE-knockout mouse (1)
- apolipoprotein E (1)
- apoptosis (1)
- arial fibrillation (1)
- arrhythmogenic cardiomyopathy (1)
- arterial elasticity (1)
- arterial stiffening (1)
- association (1)
- astrocytoma (1)
- asymmetric dimethylarginine (1)
- asymmetrisches Dimethylarginin (1)
- at-home sampling (1)
- atherogenic dyslipidaemia (1)
- atherosclerosis risk (1)
- atrial fibrillation (1)
- atrioventricular delay (1)
- autoantibodies (1)
- autoantibody (1)
- autonome Imbalance (1)
- autosomal recessive (1)
- avascular necrosis (1)
- back pain (1)
- balance (1)
- bardoxolone methyl (1)
- bariatrische Eingriffe (1)
- battery depletion (1)
- behavior (1)
- behavioral changes (1)
- benefit (1)
- beta blockers (1)
- beta-Carotin (1)
- beta-carotene (1)
- beta1-adrenergic receptor (1)
- betriebliche Gesundheitsförderung (1)
- bioinformatic clustering (1)
- biomarker prediction (1)
- biopsy (1)
- blood coagulation factor XIII (1)
- blood flow (1)
- blood plasma (1)
- blood pressure monitoring (1)
- bloodflow (1)
- blood–brain barrier (1)
- bone metabolism (1)
- bone mineral density (1)
- brain natriuretic peptide (1)
- brain pathology (1)
- branched-chain amino acids (1)
- bull’s eye plot (1)
- buparlisib (1)
- c-MYC (1)
- cAMP (1)
- calcineurin signaling cascade (1)
- calcium (1)
- calcium imaging (1)
- canagliflozin (1)
- cancer detection (1)
- cancer diagnosis (1)
- cancer risk (1)
- cancer risk factors (1)
- cancer types (1)
- cancer-testis antigens (1)
- candidate genes (1)
- cannabinoid receptor-1 antagonist (1)
- capecitabine (1)
- carcinogenesis (1)
- carcinoma (1)
- cardiac amyloidosis (1)
- cardiac arrest (1)
- cardiac dysfunction (1)
- cardiac function (1)
- cardiac implantable electronic devices (CIED) (1)
- cardiac implants (1)
- cardiac magnetic resonance (1)
- cardiac metabolism (1)
- cardiac myocytes (1)
- cardiac pacing (1)
- cardiac remodeling (1)
- cardiac resynchronization therapy (CRT) (1)
- cardiac surgery (1)
- cardiac tamponade (1)
- cardiac thrombi (1)
- cardiac training group (1)
- cardiac transplantation (1)
- cardiac troponin T (1)
- cardiac ventricles (1)
- cardiogenetics (1)
- cardiomyopathies (1)
- cardiopulmonary bypass (1)
- cardiopulmonary exercise capacity (1)
- cardiovascular MRI (1)
- cardiovascular death (1)
- cardiovascular drugs (1)
- cardiovascular events (1)
- cardiovascular morbidity (1)
- cardiovascular mortality (1)
- cardiovascular munster procam (1)
- cardiovascular outcomes (1)
- cardiovascularm disease (1)
- carotid artery disease (1)
- case report (1)
- caspase-3 (1)
- catenin (1)
- catheter tip (1)
- cathetersepsis (1)
- catheterthrombosis (1)
- cell biology (1)
- cell fusion (1)
- cell lines (1)
- cell staining (1)
- cells (1)
- cellular physiology (1)
- central nervous system (1)
- channel transport (1)
- checkpoint inhibitors (1)
- chemokines (1)
- child (1)
- chirotherapy (1)
- cholesterol (1)
- cholesterol metabolism (1)
- cholesterol- uptake (1)
- chromosomale Verlustanalyse (1)
- chromosomes (1)
- chronic heart failure (CHF) (1)
- chronic kidney disease (CKD) (1)
- chronic kidney-disease (1)
- chronic myeloid leukemia (1)
- chronic thromboembolic pulmonary hypertension (1)
- chronotype (1)
- cigarette smoking (1)
- circadian rhythms (1)
- circadian therapy (1)
- circulating microRNA (1)
- classical activation pathway (1)
- classification (1)
- clearance (1)
- clinical data warehouse (1)
- clinical genetics (1)
- clinical manifestations (1)
- clinical routine data (1)
- clinical study (1)
- clinical systems (1)
- clinical trial (1)
- clodronat-liposome (1)
- clonal hematopoiesis of indeterminate potential (1)
- cloning of putative human promoter sequence (1)
- closure AV fistula/AVM (CLAV) (1)
- co-morbid depression (1)
- coa reductase inhibitors (1)
- coagulation (1)
- coaptation line (1)
- cognition (1)
- coherent anti-Stokes Raman scattering (CARS) microscopy (1)
- cohort study (1)
- colestilan (1)
- colloids (1)
- colon carcinogenesis (1)
- color-coded (1)
- colorectal carcinoma (1)
- combination (1)
- company health care programme (1)
- comparability (1)
- comparative genomic hybridization (1)
- complex (1)
- complex‐valued machine learning (1)
- compliance (1)
- complication (1)
- congenital adrenal hyperplasia (1)
- consensus conference (1)
- contact force (1)
- converting enzyme-inhibition (1)
- coronary stent (1)
- coronary-heart-disease (1)
- correction (1)
- cortical OAT1 (1)
- corticosteroid withdrawal (1)
- corticosteroid-free immunosuppression after renal transplantation (1)
- cortisol-producing adenoma (1)
- creatine kinase (1)
- creatinine (1)
- cushing's syndrome (1)
- cyclic (1)
- cyclic nucleotides such as cyclic adenosine monophosphate (1)
- cyclosporine (1)
- cystatin c (1)
- cytochrome P450 3A4 (CYP3A4) (1)
- cytoplasmic staining (1)
- cytosol (1)
- dabrafenib (1)
- data augmentation (1)
- data warehouse (1)
- death rates (1)
- deep-vein thrombosis (1)
- deficient mice (1)
- desmin-related myopathy (1)
- desminopathy (1)
- desmocollin-2 (1)
- desmoglein-2 (1)
- deubiquitinases (1)
- dexamethasone suppression test (1)
- diabetes insipidus (1)
- diabetes melitus (1)
- diabetes typ 1 (1)
- diabetic cardiomyopathy (1)
- diabetic kidney disease (1)
- diabetische Kardiomyopathie (1)
- diagnosis in Fabry disease (1)
- diagnostic medicine (1)
- dialysate (1)
- dialysis membrane (1)
- dialyzer membrane (1)
- diastolic dysfunction (1)
- diastolic function (1)
- dietary approaches to stop hypertension (1)
- dietary sodium (1)
- dietary sodium restriction (1)
- digital Health (1)
- digital phenotyping (1)
- digital subtraction angiography (1)
- dilated cardiomyopathy (1)
- dilated cardiomyopathy with ataxia (1)
- dimensions (1)
- disease (1)
- disease score (1)
- disease severity (1)
- dissection (1)
- distant metastases (1)
- dobutamine stress echocardiography (1)
- documentation quality (1)
- dogs (1)
- double knockout mice (1)
- double-blind (1)
- doule blind (1)
- down regulation (1)
- drug interaction (1)
- drug intoxication (1)
- drug monitoring (1)
- drug therapy (1)
- drug toxicity (1)
- drug transporter (1)
- drug treatment (1)
- drug–drug interactions (DDIs) (1)
- duration of survival (1)
- dynamic (1)
- dysfunction (1)
- eGFR (1)
- eNOS-knockout (1)
- early prognosis (1)
- early-stage osteonecrosis (1)
- ecg (1)
- ecological momentary assessment (1)
- ectopic (1)
- eculizumab (1)
- elective PCI (1)
- electrocardiography (1)
- electromagnetic tracking system (1)
- electronic data capture (1)
- electronic health records (1)
- electrophysiology (1)
- electrophysiology study (1)
- elektive perkutane Koronarintervention (1)
- elektromagnetisches Trackingsystem (1)
- empagliflozin (1)
- end-stage kidney disease (1)
- endocrine cancer (1)
- endogenous hypercortisolism (1)
- endothelial (1)
- endothelial activation (1)
- endothelial adhesion molecules (1)
- endothelial cell interactions (1)
- endothelial cells (1)
- endotheliale Adhäsionsmoleküle (1)
- endotheliale Stickstoffmonoxid-Synthase (1)
- endothelin-1 (1)
- endovascular (1)
- energy homeostasis (1)
- enoxaparin (1)
- entresto (1)
- entropy production (1)
- environmental health (1)
- environmental impact (1)
- eosinophils (1)
- epithelial markers (1)
- epithelial to mesenchymal transition (1)
- erythropoietin resistance (1)
- estrogen (1)
- estrogen receptor (1)
- evidence-based practice (1)
- exercise (1)
- expectations (1)
- expression (1)
- extended matching questions (1)
- extracellular matrix (1)
- ezetimibe (1)
- fabry disease (1)
- factor XI (1)
- factor XII (1)
- failing heart (1)
- fall (1)
- fatal cardiovascular disease (1)
- fatty acids (1)
- fatty liver (1)
- feature selection (1)
- feedback (1)
- female Fabry patients (1)
- ferritin (1)
- fibroblast (1)
- fibroblast growth factor-23 (1)
- fibroblast growth factors (1)
- fibrocyt (1)
- fibronectin (1)
- filamin-C (1)
- flow dynamics (1)
- fluorescence resonance energy transfer (1)
- food consumption (1)
- fortgeschrittenes Nebennierenkarzinom (1)
- fourth (1)
- fractionation membranev (1)
- fracture (1)
- fragmin (1)
- free energy (1)
- free fatty acids (1)
- free light chains (1)
- functional regurgitation (1)
- gastric cancer (1)
- gefitinib (1)
- gender (1)
- gene (1)
- gene expression (1)
- gene variant (1)
- gene-therapy (1)
- genetic analysis (1)
- genetic loci (1)
- genetically modified animals (1)
- genome-wide association (1)
- genome-wide association study (1)
- genotype/phenotype correlation (1)
- genotyping (1)
- geriatrische Nephrologie (1)
- giant cell arteritis (1)
- glial damage (1)
- glial fibrillary acidic protein (1)
- glioblastoma (1)
- global longitudinal strain (1)
- global outcomes (1)
- glomerulonephritis (1)
- glucocorticoid excess (1)
- glucocorticoid replacement (1)
- glucocorticoid replacement regimens (1)
- glucocorticoid replacement therapy (1)
- glucose effectiveness (1)
- glucose homeostasis (1)
- glucose tolerance test (1)
- gp91phox (1)
- graft (1)
- graft versus host disease (1)
- growth differentiation factor 15 (1)
- growth hormone deficiency (1)
- guanylyl cyclase (1)
- guideline-directed medical therapy (1)
- gut microbiome (1)
- haemodiafiltration (1)
- haplotype (1)
- hashimotos-thyroiditis (1)
- healing and remodelling processes (1)
- health care (1)
- health economics (1)
- health policy (1)
- health related quality of life (1)
- health risk assessment (1)
- healthcare workers (1)
- hearing loss (1)
- hearrate (1)
- heart disease (1)
- heart failure training group (1)
- heart failure with mid-range ejection fraction (1)
- heart failure with reduced ejection fraction (1)
- helicopter (1)
- heme oxygenase-1 (1)
- hemodynamic (1)
- hemoglobin (1)
- heodialysis patients (1)
- high denisty lipoprotein (1)
- high dose dexamethasone suppression test (1)
- high molecular weight adiponectin (1)
- high-dose atorvastatin (1)
- high-resolution analysis (1)
- hip fracture (1)
- histopathology (1)
- home telemonitoring (1)
- homeostasis (1)
- homeostasisIon channels (1)
- hormones (1)
- hospitalization (1)
- hs-CRP (1)
- human behaviour (1)
- human serum albumin (1)
- hydroxy-dabrafenib (1)
- hyperandrogenemia (1)
- hypercholesterinämie (1)
- hyperosmolality (1)
- hyperparathyroidism (1)
- hyperphosphataemia (1)
- hypersensitivity (1)
- hypertensive crises (1)
- hypertensiver Krise (1)
- hypopituitary patients (1)
- hypothalamic gene expression (1)
- hypothalamische Adipositas (1)
- iNOS (1)
- iPSC-CMs (1)
- identical twins (1)
- idiopathic osteonecrosis (1)
- idiopathic pulmonary fibrosis (1)
- imaging (1)
- imaging TTE/TEE (ITTE) (1)
- immune check inhibitor (1)
- immune checkpoint inhibitor (ICI) (1)
- immune-related adverse events (1)
- immunity (1)
- immuno-modulation (1)
- immunoassays (1)
- immunofluorescence (1)
- immunohistochemistry techniques (1)
- immunosenescence (1)
- immunotherapy-induced hypophysitis (1)
- immunspressive Therapie (1)
- implantable cardioverter defibrillator (ICD) (1)
- implantation (1)
- in silico analysis (1)
- in vivo (1)
- inappropriate prescription (1)
- incidence (1)
- incremental cost-effectiveness ratio (ICER) (1)
- indoxyl sulfate (1)
- inebilizumab (1)
- infarct thickness (1)
- infarct volume (1)
- infarction size (1)
- infection (1)
- infections (1)
- inflammaging (1)
- information extraction (1)
- inhibitor of tyrosinkinase (1)
- inos (1)
- insufficiency (1)
- insulin tolerance test (1)
- intake (1)
- intensive care medicine (1)
- intensive care transport (1)
- intensive glucose control (1)
- interconversion (1)
- interhospital transfer (1)
- interleukin-6 (1)
- interleukin-8 (1)
- intermediate filaments (1)
- interparticle interaction (1)
- intra-individueller Vergleich (1)
- intrazellulärer Stress (1)
- ionic strength (1)
- ipilimumab (1)
- iron (1)
- irradiated fibroblasts (1)
- ischemia-reperfusion injury (1)
- ischemic (1)
- ischemic acute kidney injury model (1)
- ischemic heart failure (1)
- ischämische Herzinsuffizienz (1)
- isoproterenol (1)
- isturisa (1)
- italian population (1)
- kardiale Amyloidose (1)
- kardiales Remodeling (1)
- kardiopulmonale Leistungsfähigkeit (1)
- kardiovaskuläre Ereignisse (1)
- kardiovaskuläre Risikoevaluation (1)
- kardiovaskuläre Risikofaktoren (1)
- kardiovaskulärer Surrogat (1)
- kidney disease; (1)
- kidney function (1)
- kidney ischemia/reperfusion injury (1)
- kinase (1)
- kinase inhibitors (1)
- klassischer Aktivierungsweg (1)
- knockout mice (1)
- knockout-Mäuse (1)
- kognitive Beeinträchtigung (1)
- kollagen deficiency (1)
- komorbide Depression (1)
- kontemplative Meditation und Atemtechniken (CMBT) (1)
- koronare Herzkrankheit (1)
- lactase persistence (1)
- lactic acidosis (1)
- lactose (1)
- large animal models (1)
- laxative (1)
- leaflet (1)
- left ventricular geometric abnormality (1)
- left ventricular geometry (1)
- left ventricular mass (1)
- left ventricular mass index (1)
- left ventricular non-compaction (1)
- left ventricular performance (1)
- left ventricular remodeling (1)
- left ventricular thrombus (1)
- left ventricular thrombusv (1)
- leicht reduzierte Herzinsuffizienz (1)
- leitliniengerechte Pharmakotherapie (1)
- leitliniengerechte Therapie (1)
- leptin system (1)
- lesion formation (1)
- lesion size (1)
- leukocyte adhesion (1)
- leukocyte-endothelial-interactions (1)
- leukocytes (1)
- lifestyle (1)
- lifestyle modification (1)
- linkage (1)
- linksventrikulärer Thrombus (1)
- lipid droplets (1)
- lipid-lowering therapy (1)
- lipoprotein apheresis (1)
- lipoprotein(a) (1)
- lipoxygenase knockout (1)
- liquid chromatography tandem mass spectrometry (LC-MS/MS (1)
- liquid chromatography–tandem mass spectrometry (LC–MS/MS) (1)
- livin (1)
- lncRNA (1)
- long-term follow-up (1)
- long-term ventilation (1)
- longitudinal function (1)
- longitudinal studies (1)
- longitudinale Funktion (1)
- loss (1)
- low molecular weight (1)
- low-gradient AS (1)
- lower limit of normal (1)
- lung cancer (1)
- lung fibroblasts (1)
- lycopene (1)
- lymph node dissection (1)
- lymph nodes (1)
- lymphadenectomy (1)
- lysophosphatidylcholine (1)
- lysosomal storage disease (1)
- lysosomal storage disorder (1)
- lyso‐Gb3 (1)
- m exercise training (1)
- mCRP (1)
- mHealth (1)
- macrophages (1)
- macrovascular (1)
- malignant tumors (1)
- manuelle Diagnostik (1)
- mass spectronomy (1)
- meat (1)
- medical data integration center (1)
- medical dialysis (1)
- medical informatics initiative (1)
- medical students (1)
- medical therapy (1)
- medication extraction (1)
- medium cut-off dialyzer (1)
- medullary thyroid cancer (1)
- membranous nephropathy (1)
- men born (1)
- menopause (1)
- mental impairment (1)
- mesenchymal markers (1)
- meta-analysis (1)
- metabolic syndrome (1)
- metabolically unhealthy obesity (1)
- metachronous (1)
- metastasis (1)
- metastatic (1)
- metformin (1)
- metyrapone (1)
- miR-182-5p (1)
- miR-183 cluster (1)
- miR-483-5p (1)
- miRNA infarcted heart (1)
- miRNS (1)
- mices (1)
- microcirculation (1)
- microvascular (1)
- mild (1)
- mild to moderate CKD (1)
- military (1)
- mineral bone density (1)
- mineral metabolism (1)
- minerals (1)
- minimal regional loss (1)
- minimale Verlustregion (1)
- mitochondria (1)
- mitochondria function and morphology (1)
- mitochondrial mRyR1 (1)
- mitofusin 2 (1)
- mitogenic signal transduction (1)
- mitral ring displacement (1)
- mitral ring motion (1)
- mitral valve (1)
- mittlerer transvalvulärer Druckgradient (1)
- mobile crowdsensing (1)
- mobile health (1)
- model (1)
- modified-release hydrocortisone (1)
- molecular biology (1)
- molecular diagnostics (1)
- monocytes (1)
- morbidity (1)
- mortality reduction (1)
- motion detector (1)
- mouse model (1)
- multi-tyrosine kinase inhibitor (1)
- multidetector computed-tomography (1)
- multiple choice questions (1)
- multiple myeloma (1)
- multiple sclerosis (1)
- multivariate data analysis (1)
- muscle fiber types (1)
- mutation (1)
- mutation databases (1)
- mutation triggers (1)
- mutations (1)
- myocardial (1)
- myocardial aging (1)
- myocardial ischemia (1)
- myocardial work efficiency (1)
- myocardial fibrosis (1)
- myocardial-infarction (1)
- myocarditis (1)
- myocardium (1)
- myokardial infarction (1)
- myosin heavy chain (1)
- nCRP (1)
- nNOS (1)
- natural history (1)
- neck circumference (1)
- neonatal (1)
- nephrotic syndrome (1)
- nerve fibers (1)
- neural networks (1)
- neuroblastoma – diagnosis (1)
- neurofibromatosis type 1 (1)
- neuroinflammation (1)
- neurological (1)
- neurological complications (1)
- neurology (1)
- neuromyelitis optica spectrum disorders (1)
- neuronal nitric oxide synthase (1)
- neurons (1)
- neuropathy (1)
- neuroscience (1)
- neutral loss (1)
- neutrophils (1)
- nitric oxide bioavailability (1)
- nivolumab (1)
- non small cell lung cancer (1)
- non-equilibrium thermodynamics (1)
- non-triggered (1)
- noncontact monitoring (1)
- nontraumatic osteonecrosis of the femoral head (1)
- normal adrenal glands (1)
- normal values (1)
- normotensiv (1)
- normotensive (1)
- notch signaling (1)
- nuclear staining (1)
- nutritional components (1)
- nutritional counseling (1)
- nutritional medical needs (1)
- nutritional risk screening (1)
- obesity surgery (1)
- occupational-status (1)
- on-site examination (1)
- oncology outpatients (1)
- openEHR (1)
- operation (1)
- opossum kidney cells (1)
- optimale Herzkatheterprojektionen (1)
- optional angiographic views (1)
- oral chemotherapy (1)
- oral glucose (1)
- orale Chemotherapie (1)
- organoid (1)
- osilodrostat (1)
- osimertinib (1)
- osmotic stimulation (1)
- osteocalcin (1)
- osteogenesis imperfecta (1)
- ostial segments (1)
- outcome (1)
- overload (1)
- overweight simulation (1)
- oxidativer Stress (1)
- oxidized LDL (1)
- oxidized low-density-lipoprotein (1)
- p-cresyl sulfate (1)
- p38 MAPK (1)
- paired (1)
- pancreatic beta cell (1)
- pandemia (1)
- panel (1)
- pankreatische beta-Zelle (1)
- papillary (1)
- papillary thyroid carcinoma (PTC) (1)
- para-Cresyl-Sulfat (1)
- parallel imaging (1)
- parathyroid carcinoma (1)
- paravalvular regurgitation (1)
- pathogenesis (1)
- pathophysiology (1)
- patient survival (1)
- patientenorientierte Versorgung (1)
- pediatric (1)
- pediatric adrenocortical adenoma (1)
- pediatric adrenocortical cancer (1)
- pediatric adrenocortical tumor (1)
- peptide tyrosine tyrosine 3-36 (PYY3-36) (1)
- peptide tyrosine tyrosine 3-36 (PYY\(_{3-36}\)) (1)
- percutaneous valve therapy (PVT) (1)
- performance (1)
- pericardiocentesis (1)
- perioperative chemotherapy (1)
- peritoneal carcinomatosis (1)
- perkutane transluminale koronare Angioplastie (1)
- personalised medicine (1)
- personalized antimicrobial therapy (1)
- personalized medicine (1)
- personalized treatment (1)
- pharmacoepidemiology (1)
- pharmacokinetics (1)
- phase IV (1)
- phase-contrast CMR (1)
- pheochromocytoma/paraganglioma (1)
- pheochromozytom (1)
- phosphate homeostasis (1)
- phosphatidylcholines (1)
- phosphodiesterase inhibitor (1)
- phospholipid fatty acids (1)
- phosphorylated tau protein (1)
- phosphorylation (1)
- physiologically based pharmacokinetic (PBPK) modeling (1)
- physische Aktivität (1)
- pig (1)
- pioglitazone (1)
- piperacillin/tazobactam (1)
- pituitary (1)
- pituitary adenomas (1)
- pituitary gland (1)
- placebo (1)
- plant-derived metabolites (1)
- plaque characteristics (1)
- plasma (1)
- plasma proteins (1)
- platelet (1)
- platelet activation (1)
- platelet adhesion (1)
- platinum (1)
- pleural mesothelioma (1)
- polarization (1)
- poly(2-oxazoline) (1)
- polycystic ovary syndrome (1)
- polyglandular autoimmune syndrome (1)
- polymorphism (1)
- polymyalgia rheumatica (1)
- population (1)
- population pharmacokinetics (1)
- population-based (1)
- population-based study (1)
- posaconazole (1)
- post-traumatic stress disorder (1)
- postprandial hyperglycemia (1)
- postprandiale Hyperglykämie (1)
- posttraumatische Belastungsstörung (1)
- poultry (1)
- preclinical research (1)
- prediction model (1)
- predictive marker (1)
- predictors (1)
- premature mortality (1)
- preventive medicine (1)
- primary aldosteronism (1)
- primary care (1)
- primary healthcare (1)
- primary hypophysitis (1)
- primary polydipsia (1)
- primärer Hyperaldosteronismus (1)
- procollagen (1)
- prognostic biomarker (1)
- prognostic marker (1)
- prognostic markers (1)
- progression (1)
- proliferationsassoziierte Signaltransduktion (1)
- propionic acid (1)
- prospective (1)
- prospektive Studie (1)
- prostaglandin e2 (1)
- prostate cancer (1)
- protein binding (1)
- protein expression (1)
- protein kinase a (1)
- protein p8 (1)
- protein-bound solutes (1)
- protein-bound uremic toxins (1)
- proteinuria (1)
- proteomic (1)
- pseudo-severe AS (1)
- pseudo-severe aortic stenosis (1)
- psychiatric disorders (1)
- psychopharmacology (1)
- psychotherapy (1)
- public health (1)
- pulmonary artery pressure (1)
- pulmonary cancer (1)
- pulmonary fibrosis (1)
- pulse wave velocity (1)
- pulse-wave velocity (1)
- qualitative Forschung (1)
- quantitative MRI (1)
- radiation fibrosis (1)
- radiation pneumonitis (1)
- radiation therapy (1)
- radical resection (1)
- radii (1)
- radiochemotherapy (1)
- radiofrequency ablation (1)
- radiogene Lungenfibrose (1)
- radiogenic lung fibrosis (1)
- radioiodine (1)
- radioiodine therapy (1)
- randomized controlled trial (1)
- randomized controlled-trial (1)
- randomized trial (1)
- ravulizumab (1)
- reaktive Sauerstoffspezies (1)
- real-world (1)
- rearranged during transfection (1)
- recombination hotspot (1)
- recommendations (1)
- recovery (1)
- recurrence free survival (1)
- recurrence survival (1)
- recurrence-free survival (1)
- reduzierte Herzinsuffizienz (1)
- reference data (1)
- refugee healthcare (1)
- regression analysis (1)
- regulation of expression (1)
- regurgitation (1)
- remote monitoring (1)
- removal (1)
- renal (1)
- renal artery (1)
- renal disease (1)
- renal dysfunction (1)
- renal replacement therapy (1)
- renal system (1)
- renoprotection (1)
- reoperation (1)
- repeated (1)
- repeated surgery (1)
- reporter gen assay (1)
- reproductive disorders (1)
- research infrastructure (1)
- residual cardiovascular risk (1)
- respiratory signs and symptoms (1)
- retrospektiv (1)
- review (1)
- re‐transplantation (1)
- rheumatic disease (1)
- rheumatoid arthritis (1)
- rhoA (1)
- right ventricular dysfunction (1)
- risk factor control (1)
- risk prediction scores (1)
- risk stratification (1)
- rodent model (1)
- root (1)
- running wheel (1)
- ruxolitinib (1)
- rygb (1)
- sGC (1)
- sacubitril-valsartan (1)
- salt-dependend (1)
- salzinduziert (1)
- sarcoidosis (1)
- satralizumab (1)
- secondary data usage (1)
- secondary prevention (1)
- segmentation (1)
- self-gating (1)
- selpercatinib (1)
- semantic interoperability (1)
- septic shock (1)
- sequence databases (1)
- serielle Messungen (1)
- seroprevalence (1)
- serotonin (1)
- serotonin transporter deficient mice (1)
- serum (1)
- sevelamer (1)
- severe renal insufficiency (1)
- severe sepsis (1)
- sex differences (1)
- shear stress (1)
- shimming (1)
- short Synacthen test (1)
- short term (1)
- short-chain fatty acids (1)
- signal voids (1)
- signalling (1)
- signs (1)
- signs and symptoms (1)
- simulation (1)
- single nucleotide polymorphisms (1)
- skin diseases (1)
- small animal (1)
- small cell lung cancer (SCLC) (1)
- small interfering RNAs (1)
- smoking (1)
- sodium (1)
- sodium-23 (1)
- sodium-glucose co-transporter-2 inhibitors (1)
- solubility enhancement (1)
- somatic mutations (1)
- somatostatin receptor (1)
- spannungsabhängig (1)
- speckle tracking (1)
- speckle tracking imaging (1)
- speech recognition (1)
- sphingolipids (1)
- spin lock (1)
- spin-lock (1)
- spiritual-wholistic treatment (1)
- sports and exercise medicine (1)
- stage renal-disease (1)
- standard heparin (1)
- state space (1)
- statement (1)
- statistical mechanics (1)
- stenosis (1)
- stepcount (1)
- steroid measurement (1)
- steroids (1)
- strain (1)
- strain rate (1)
- stress induced Hypertension (1)
- stress instructions (1)
- stressinduzierte Hypertonie (1)
- subjective health-status (1)
- sudden cardiac death (1)
- sudden death (1)
- sulfonylurea (1)
- surgical and invasive medical procedures (1)
- surgical oncology (1)
- surgical repair (1)
- surveillance (1)
- susceptibility (1)
- systemic micro-inflammation oxidative stress (1)
- systems biology (1)
- t-lymphocytes (1)
- tail cuff method (1)
- target therapies (1)
- targeted gene panel (1)
- targeted metabolomics (1)
- targeted therapy (1)
- targeted treatment (1)
- telemedicine (1)
- telomeres (1)
- temperature (1)
- tenting (1)
- term fenofibrate therapy (1)
- terminale Niereninsuffizienz (1)
- testosterone (1)
- therapeutic approach (1)
- therapeutic management (1)
- therapeutic options (1)
- thermodynamics (1)
- third (1)
- thoracic aorta (1)
- three-dimensional echocardiography (1)
- thrombocyte activation (1)
- thromboembolism (1)
- thromboinflammation (1)
- thrombopoiesis (1)
- thyroid carcinoma (TC) (1)
- tight junctions (1)
- timing (1)
- tissue (1)
- tissue doppler (1)
- tissue velocity imaging (1)
- tocilizumab (1)
- tomography (1)
- training (1)
- trametinib (1)
- transcatheter valveimplantation (TVI) (1)
- transfer learning (1)
- transforming growth factor beta 1 (1)
- transgen (1)
- transgenic (1)
- transgenic mouse (1)
- transgenic rats (1)
- translation (1)
- translational research (1)
- transport experiments (1)
- transthoracic echocardiography (1)
- treatment outcome (1)
- trial design (1)
- tricuspid pressure gradient (1)
- triglyceride-rich lipoproteins (1)
- troponin T (1)
- true-severe aortic stenosis (1)
- tumor (1)
- tumor microenvironment (1)
- tumor suppressor gene (1)
- tumor-infiltrating (1)
- tumors (1)
- tumour (1)
- type 2 (1)
- type 2 diabetes mellitus (1)
- type-1 diabetes mellitus (1)
- type-2 diabetes mellitus (1)
- tyrosine kinase inhibitor (TKI) (1)
- tyrosine kinase inhibitors (1)
- ublituximab (1)
- ultra highfield magnetic resonance imaging (1)
- ultrahigh field (1)
- ultrahigh-field (1)
- ultrahigh-field MRI (1)
- ultrasound guided (1)
- unfractionated heparin (1)
- ungeschützter linker Hauptstamm (1)
- unprotected left main (1)
- unsupervised clustering (1)
- urine (1)
- usability (1)
- use (1)
- user-centered design (1)
- validation (1)
- variant (1)
- vascular surgery (1)
- vasoconstriction (1)
- vemurafenib (1)
- ventricular fibrillation (1)
- ventricular ruptur (1)
- ventrikuläre Tachykardie (1)
- verification of suspected diagnoses (1)
- vertigo (1)
- vibration (1)
- viral infection (1)
- virtual-reality (1)
- vitamins (1)
- voltage (1)
- volume (1)
- volumetric absorptive micro-sampling (VAMS) (1)
- waist circumference (1)
- warfarin (1)
- weaning (1)
- whole exome sequencing (1)
- wires (1)
- yellow fluorescent protein (1)
- Übergewicht (1)
- Übergewichts-Simulation (1)
- Überleben (1)
- ältere Menschen (1)
- α- und β-Agalsidase (1)
- α-Agalsidase (1)
- α‐GalA 3D‐structure (1)
- β-Agalsidase (1)
Institute
- Medizinische Klinik und Poliklinik I (547) (remove)
Sonstige beteiligte Institutionen
- Zentraleinheit Klinische Massenspektrometrie (3)
- Johns Hopkins School of Medicine (2)
- Johns Hopkins School of Medicine, Baltimore, MD, U.S. (2)
- Apotheke, Universitätsklinikum Würzburg (1)
- Center for Interdisciplinary Clinical Research, Würzburg University, Würzburg, Germany (1)
- Datenintegrationszentrum Würzburg (DIZ) (1)
- Hospital Augsburg, Augsburg, Germany (1)
- Interdisziplinäre Biomaterial- und Datenbank Würzburg (ibdw) (1)
- Interdisziplinäres Amyloidosezentrum Nordbayern (1)
- Johns Hopkins University School of Medicine (1)
Increased sympathetic noradrenergic signaling is crucially involved in fear and anxiety as defensive states. MicroRNAs regulate dynamic gene expression during synaptic plasticity and genetic variation of microRNAs modulating noradrenaline transporter gene (SLC6A2) expression may thus lead to altered central and peripheral processing of fear and anxiety. In silico prediction of microRNA regulation of SLC6A2 was confirmed by luciferase reporter assays and identified hsa-miR-579-3p as a regulating microRNA. The minor (T)-allele of rs2910931 (MAFcases = 0.431, MAFcontrols = 0.368) upstream of MIR579 was associated with panic disorder in patients (pallelic = 0.004, ncases = 506, ncontrols = 506) and with higher trait anxiety in healthy individuals (pASI = 0.029, pACQ = 0.047, n = 3112). Compared to the major (A)-allele, increased promoter activity was observed in luciferase reporter assays in vitro suggesting more effective MIR579 expression and SLC6A2 repression in vivo (p = 0.041). Healthy individuals carrying at least one (T)-allele showed a brain activation pattern suggesting increased defensive responding and sympathetic noradrenergic activation in midbrain and limbic areas during the extinction of conditioned fear. Panic disorder patients carrying two (T)-alleles showed elevated heart rates in an anxiety-provoking behavioral avoidance test (F(2, 270) = 5.47, p = 0.005). Fine-tuning of noradrenaline homeostasis by a MIR579 genetic variation modulated central and peripheral sympathetic noradrenergic activation during fear processing and anxiety. This study opens new perspectives on the role of microRNAs in the etiopathogenesis of anxiety disorders, particularly their cardiovascular symptoms and comorbidities.
Metastatic pheochromocytoma and paraganglioma: signs and symptoms related to catecholamine secretion
(2021)
Background
The presence or future development of metastatic pheochromocytomas or paragangliomas (mPPGLs) can be difficult to diagnose or predict at initial presentation. Since production of catecholamines from mPPGLs is different from non-metastatic tumors (non-mPPGLs), this study aimed to clarify whether presenting catecholamine-related signs and symptoms (cSS) might also differ.
Methods
The study included 249 patients, 43 with mPPGL and 206 with non-mPPGL. Clinical data at the time of biochemical diagnosis (i.e. at entry into the study) were used to generate a cumulative score of cSS for each patient.
Results
Patients with mPPGL were significantly younger (43.3 ± 14 vs. 48.9 ± 16.1 years) and included a lower proportion of females (39.5% vs. 60.7%) than patients with non-mPPGLs. Frequencies of signs and symptoms did not differ between the two groups. Patients with mPPGLs had lower (P < 0.001) urinary excretion of epinephrine (3.5 (IQR, 1.9—6.5) µg/day) than those with non-mPPGLs (19.1 (IQR, 4.3—70.2) µg/day). There was no difference in urinary excretion of norepinephrine. In patients with mPPGLs a high cSS score was associated with high urinary excretion of norepinephrine and normetanephrine. In contrast, in patients with non-mPPGLs, a high cSS was associated with high urinary excretion of epinephrine and metanephrine.
Conclusion
Although presenting signs and symptoms were associated with production of norepinephrine in patients with mPPGLs and of epinephrine in patients with non-mPPGLs, there were no differences in signs and symptoms between the two groups. Therefore, consideration of signs and symptoms does not appear helpful for distinguishing patients with and without mPPGLs.
Purpose
The subclassification of adrenal cancers according to the WHO classification in ordinary, myxoid, oncocytic, and sarcomatoid as well as pediatric types is well established, but the criteria for each subtype are not sufficiently determined and the relative frequency of the different types of adrenal cancers has not been studied in large cohorts. Therefore, our large collection of surgically removed adrenal cancers should be reviewed o establish the criteria for the subtypes and to find out the frequency of the various types.
Methods
In our series of 521 adrenal cancers the scoring systems of Weiss et al., Hough et al., van Slooten et al. and the new Helsinki score system were used for the ordinary type of cancer (97% of our series) and the myxoid type (0.8%). For oncocytic carcinomas (2%), the scoring system of Bisceglia et al. was applied.
Results
Discrepancies between benign and malignant diagnoses from the first thee classical scoring systems are not rare (22% in our series) and could be resolved by the Helsinki score especially by Ki-67 index (more than 8% unequivocally malignant). Since all our cancer cases are positive in the Helsinki score, this system can replace the three elder systems. For identification of sarcomatoid cancer as rarest type in our series (0.2%), the scoring systems are not practical but additional immunostainings used for soft tissue tumors and in special cases molecular pathology are necessary to differentiate these cancers from adrenal sarcomas. According to the relative frequencies of the different subtypes of adrenal cancers the main type is the far most frequent (97%) followed by the oncocytic type (2%), the myxoid type (0.8%) and the very rare sarcomatoid type (0.2%).
Conclusions
The Helsinki score is the best for differentiating adrenal carcinomas of the main, the oncocytic, and the myxoid type in routine work. Additional scoring systems for these carcinomas are generally not any longer necessary. Signs of proliferation (mitoses and Ki-67 index) and necroses are the most important criteria for diagnosis of malignancy.
Context
Primary aldosteronism (PA) is the most frequent form of endocrine hypertension. Besides its deleterious impact on cardiovascular target organ damage, PA is considered to cause osteoporosis.
Patients and methods
We assessed bone turnover in a subset of 36 postmenopausal women with PA. 18 patients had unilateral PA and were treated by adrenalectomy, whereas 18 patients had bilateral PA and received mineralocorticoid receptor antagonist (MRA) therapy respectively. 18 age- and BMI-matched females served as controls. To estimate bone remodeling, we measured the bone turnover markers intact procollagen 1 N-terminal propeptide, bone alkaline phosphatase, osteocalcin and tartrate resistant acid phosphatase 5b in plasma by chemiluminescent immunoassays at time of diagnosis and one year after initiation of treatment.
Study design
Observational longitudinal cohort study.
Setting
Tertiary care hospital.
Results
Compared with controls, patients with PA had mildly elevated osteocalcin at baseline (p = 0.013), while the other bone markers were comparable between both groups. There were no differences between the unilateral and the bilateral PA subgroup. One year after initiation of MRA treatment with spironolactone bone resorption and bone formation markers had significantly decreased in patients with bilateral PA. In contrast, patients adrenalectomized because of unilateral PA showed no significant change of bone turnover markers.
Conclusion
This study shows that aldosterone excess in postmenopausal women with PA is not associated with a relevant increase of bone turnover markers at baseline. However, we observed a significant decrease of bone markers in patients treated with spironolactone, but not in patients treated by adrenalectomy.
Purpose
Pheochromocytomas and Paragangliomas (PPGL) result in chronic catecholamine excess and serious health complications. A recent study obtained a metabolic signature in plasma from PPGL patients; however, its targeted nature may have generated an incomplete picture and a broader approach could provide additional insights. We aimed to characterize the plasma metabolome of PPGL patients before and after surgery, using an untargeted approach, and to broaden the scope of the investigated metabolic impact of these tumors.
Design
A cohort of 36 PPGL patients was investigated. Blood plasma samples were collected before and after surgical tumor removal, in association with clinical and tumor characteristics.
Methods
Plasma samples were analyzed using untargeted nuclear magnetic resonance (NMR) spectroscopy metabolomics. The data were evaluated using a combination of uni- and multi-variate statistical methods.
Results
Before surgery, patients with a nonadrenergic tumor could be distinguished from those with an adrenergic tumor based on their metabolic profiles. Tyrosine levels were significantly higher in patients with high compared to those with low BMI. Comparing subgroups of pre-operative samples with their post-operative counterparts, we found a metabolic signature that included ketone bodies, glucose, organic acids, methanol, dimethyl sulfone and amino acids. Three signals with unclear identities were found to be affected.
Conclusions
Our study suggests that the pathways of glucose and ketone body homeostasis are affected in PPGL patients. BMI-related metabolite levels were also found to be altered, potentially linking muscle atrophy to PPGL. At baseline, patient metabolomes could be discriminated based on their catecholamine phenotype.
Therapy options for adrenal insufficiency and recommendations for the management of adrenal crisis
(2021)
Adrenal insufficiency (AI) is a life-threatening condition requiring life-long glucocorticoid (GC) substitution therapy, as well as stress adaptation to prevent adrenal crises. The number of individuals with primary and secondary adrenal insufficiency in Europe is estimated to be 20–50/100.000. A growing number of AI cases are due to side effects of GC treatment used in different treatment strategies for cancer and to immunotherapy in cancer treatment. The benefit of hormone replacement therapy is evident but long-term adverse effects may arise due to the non-physiological GC doses and treatment regimens used. Given multiple GC replacement formulations available comprising short-acting, intermediate, long-acting and novel modified-release hydrocortisone as well as subcutaneous formulations, this review offers a concise summary on the latest therapeutic improvements for treatment of AI and prevention of adrenal crises. As availability of various glucocorticoid formulations and access to expert centers across Europe varies widely, European Reference Networks on rare endocrine conditions aim at harmonizing treatment and ensure access to specialized patient care for individual case-by-case treatment decisions. To improve the availability across Europe to cost effective oral and parenteral formulations of hydrocortisone will save lives.
Differences between immunotherapy-induced and primary hypophysitis—a multicenter retrospective study
(2022)
Objective
Immune checkpoint inhibitors can cause various immune-related adverse events including secondary hypophysitis. We compared clinical characteristics of immunotherapy-induced hypophysitis (IIH) and primary hypophysitis (PH)
Design
Retrospective multicenter cohort study including 56 patients with IIH and 60 patients with PH.
Methods
All patients underwent extensive endocrine testing. Data on age, gender, symptoms, endocrine dysfunction, MRI, immunotherapeutic agents and autoimmune diseases were collected.
Results
Median time of follow-up was 18 months in IIH and 69 months in PH. The median time from initiation of immunotherapy to IIH diagnosis was 3 months. IIH affected males more frequently than PH (p < 0.001) and led to more impaired pituitary axes in males (p < 0.001). The distribution of deficient adenohypophysial axes was comparable between both entities, however, central hypocortisolism was more frequent (p < 0.001) and diabetes insipidus considerably less frequent in IIH (p < 0.001). Symptoms were similar except that visual impairment occurred more rarely in IIH (p < 0.001). 20 % of IIH patients reported no symptoms at all. Regarding MRI, pituitary stalk thickening was less frequent in IIH (p = 0.009). Concomitant autoimmune diseases were more prevalent in PH patients before the diagnosis of hypophysitis (p = 0.003) and more frequent in IIH during follow-up (p = 0.002).
Conclusions
Clinically, IIH and PH present with similar symptoms. Diabetes insipidus very rarely occurs in IIH. Central hypocortisolism, in contrast, is a typical feature of IIH. Preexisting autoimmunity seems not to be indicative of developing IIH.
Background: Monitoring the vital signs of delirious patients in an intensive care unit (ICU) is challenging, as they might (un-)intentionally remove devices attached to their bodies. In mock-up scenarios, we systematically assessed whether a motion detector (MD) attached to the bed may help in identifying emergencies. Methods: We recruited 15 employees of the ICU and equipped an ICU bed with an MD (IRON Software GmbH, Grünwald, Germany). Participants were asked to replay 22 mock-up scenes of one-minute duration each: 12 scenes with movements and 10 without movements, of which 5 were emergency scenes (“lying dead-still, with no or very shallow breathing”). Blinded recordings were presented to an evaluation panel consisting of an experienced ICU nurse and a physician, who was asked to assess and rate the presence of motions. Results: Fifteen participants (nine women; 173 ± 7.0 cm; 78 ± 19 kg) joined the study. In total, 286 out of 330 scenes (86.7%) were rated correctly. Ratings were false negative (FN: “no movements detected, but recorded”) in 7 out of 180 motion scenes (3.9%). Ratings were false positive (FP: “movements detected, but not recorded”) in 37 out of 150 scenes (24.7%), more often in men than women (26 out of 60 vs. 11 out of 90, respectively; p < 0.001). Of note, in 16 of these 37 FP-rated scenes, a vibrating mobile phone was identified as a potential confounder. The emergency scenes were correctly rated in 64 of the 75 runs (85.3%); 10 of the 11 FP-rated scenes occurred in male subjects. Conclusions: The MD allowed for identifying motions of test subjects with high sensitivity (96%) and acceptable specificity (75%). Accuracy might increase further if activities are recorded continuously under real-world conditions.
Adrenocortical carcinoma (ACC) represents a rare tumor entity with limited treatment options and usually rapid tumor progression in case of metastatic disease. As further treatment options are needed and ACC metastases are sensitive to external beam radiation, novel theranostic approaches could complement established therapeutic concepts. Recent developments focus on targeting adrenal cortex-specific enzymes like the theranostic twin [\(^{123/131}\)I]IMAZA that shows a good image quality and a promising therapeutic effect in selected patients. But other established molecular targets in nuclear medicine such as the C-X-C motif chemokine receptor 4 (CXCR4) could possibly enhance the therapeutic regimen as well in a subgroup of patients. The aims of this review are to give an overview of innovative radiopharmaceuticals for the treatment of ACC and to present the different molecular targets, as well as to show future perspectives for further developments since a radiopharmaceutical with a broad application range is still warranted.
Serum liquid chromatography–tandem mass spectrometry (LC–MS/MS) steroid profiling is used for the diagnosis of adrenocortical carcinoma (ACC). Guidelines recommend endocrine work-up in addition to radiological imaging for follow-up in ACC, but data on this topic are scarce. Patients were included in this retrospective study if pre-therapeutic hormone values, regular tumour evaluation by imaging, steroid measurements by LC–MS/MS, and details on therapies were available. The utility of steroid profiles in detecting recurrence or disease progression was assessed, whereby “endocrine progress” was defined by an elevation of at least 3 of 13 analysed hormones. Cohort A included 47 patients after R0 resection, of whom 15 experienced recurrence and 32 did not. In cohort B, 52 patients with advanced disease (including 7 patients of cohort A with recurrence) could be evaluated on 74 visits when progressive disease was documented. In 20 of 89 cases with documented disease progression, “endocrine progress” was detectable prior to radiological progress. In these cases, recurrence/progression was detected at a median of 32 days earlier by steroid measurement than by imaging, with 11-deoxycortisol and testosterone being the most sensitive markers. Notably, these patients had significantly larger tumour burden. In conclusion, steroid profiling by LC–MS/MS is of value in detecting recurrent/progressive disease in ACC.
Safety and tolerability of SGLT2 inhibitors in cardiac amyloidosis — a clinical feasibility study
(2024)
Sodium-glucose transport protein 2 inhibitors (SGLT2i) slow the progression of renal dysfunction and improve the prognosis of patients with heart failure. Amyloidosis constitutes an important subgroup for which evidence is lacking. Amyloidotic fibrils originating from misfolded transthyretin and light chains are the causal agents in ATTR and AL amyloidosis. In these most frequent subtypes, cardiac involvement is the most common organ manifestation. Because cardiac and renal function frequently deteriorate over time, even under best available treatment, SGLT2i emerge as a promising treatment option due to their reno- and cardioprotective properties. We retrospectively analyzed patients with cardiac amyloidosis, who received either dapagliflozin or empagliflozin. Out of 79 patients, 5.1% had urinary tract infections; 2 stopped SGLT2i therapy; and 2.5% died unrelated to the intake of SGLT2i. No genital mycotic infections were observed. As expected, a slight drop in the glomerular filtration rate was noted, while the NYHA functional status, cardiac and hepatic function, as well as the 6 min walk distance remained stable over time. These data provide a rationale for the use of SGLT2i in patients with amyloidosis and concomitant cardiac or renal dysfunction. Prospective randomized data are desired to confirm safety and to prove efficacy in this increasingly important group of patients.
Objectives
The spectrum of giant cell arteritis (GCA) and polymyalgia rheumatica (PMR) represents highly inflammatory rheumatic diseases. Patients mostly report severe physical impairment. Possible consequences for mental health have been scarcely studied. The aim of this study was to investigate psychological well-being in the context of GCA and PMR.
Methods
Cross-sectional study with N = 100 patients with GCA and/or PMR (GCA-PMR). Patient-reported outcomes (PROs) were measured using the Short Form 36 Version 2 (SF-36v2) and visual analog scale (VAS) assessment. Moreover, the Patient Health Questionnaire 9 (PHQ-9) was used in 35 of 100 patients to detect depression. To compare PROs with physician assessment, VAS was also rated from physician perspective. To assess a possible association with inflammation itself, serological parameters of inflammation (C-reactive protein [CRP], erythrocyte sedimentation rate [ESR]) were included.
Results
In all scales of the SF-36v2 except General Health (GH) and in the physical and mental sum score (PCS, MCS), a significant impairment compared to the German reference collective was evident (MCS: d = 0.533, p < 0.001). In the PHQ-9 categorization, 14 of the 35 (40%) showed evidence of major depression disorder. VAS Patient correlated significantly with PHQ-9 and SF-36 in all categories, while VAS Physician showed only correlations to physical categories and not in the mental dimensions. Regarding inflammatory parameters, linear regression showed CRP to be a complementary significant positive predictor of mental health subscale score, independent of pain.
Conclusion
PRO show a relevant impairment of mental health up to symptoms of major depression disorder. The degree of depressive symptoms is also distinctly associated with the serological inflammatory marker CRP.
Purpose
Over the course of COVID-19 pandemic, evidence has accumulated that SARS-CoV-2 infections may affect multiple organs and have serious clinical sequelae, but on-site clinical examinations with non-hospitalized samples are rare. We, therefore, aimed to systematically assess the long-term health status of samples of hospitalized and non-hospitalized SARS-CoV-2 infected individuals from three regions in Germany.
Methods
The present paper describes the COVIDOM-study within the population-based cohort platform (POP) which has been established under the auspices of the NAPKON infrastructure (German National Pandemic Cohort Network) of the national Network University Medicine (NUM). Comprehensive health assessments among SARS-CoV-2 infected individuals are conducted at least 6 months after the acute infection at the study sites Kiel, Würzburg and Berlin. Potential participants were identified and contacted via the local public health authorities, irrespective of the severity of the initial infection. A harmonized examination protocol has been implemented, consisting of detailed assessments of medical history, physical examinations, and the collection of multiple biosamples (e.g., serum, plasma, saliva, urine) for future analyses. In addition, patient-reported perception of the impact of local pandemic-related measures and infection on quality-of-life are obtained.
Results
As of July 2021, in total 6813 individuals infected in 2020 have been invited into the COVIDOM-study. Of these, about 36% wished to participate and 1295 have already been examined at least once.
Conclusion
NAPKON-POP COVIDOM-study complements other Long COVID studies assessing the long-term consequences of an infection with SARS-CoV-2 by providing detailed health data of population-based samples, including individuals with various degrees of disease severity.
Trial registration
Registered at the German registry for clinical studies (DRKS00023742).
Ziel dieser Studie war es, zu eruieren, ob die DSE zur Unterscheidung einer TS- von einer PSAS beitragen kann. Ebenfalls untersuchten wir, ob es bestimmte echokardiographische Prädiktoren für eine TS- und eine PSAS gibt und ob die LVEF bei Patienten mit einer LGAS eine entscheidende Rolle spielt. Methoden: Es wurde bei 130 Patienten mit einer asymptomatischen AS im Uniklinikum Würzburg zwischen Januar 2011 und Dezember 2016 sowohl eine TTE als auch eine DSE durchgeführt. Mittels TTE wurden verschiedene echokardiographische Daten erhoben und falls die Patienten eine AVAi 0,6 cm2/m2 und eine PGmean < 40 mmHg aufwiesen, wurden sie in die Studie eingeschlossen. Sie wurden in zwei Gruppen aufgeteilt, je nachdem ob sie eine LGAS mit einer LVEF 50% oder < 50% aufwiesen. Bei allen Patienten wurde in der DSE die AVAproj berechnet und sie wurden daraufhin in zwei Untergruppen aufgeteilt, Patienten mit einer AVAproj 1 cm2 wurden der Gruppe mit einer hochgradigen LGAS (TS-LGAS) und Patienten mit einer AVAproj > 1cm2 der Gruppe mit einer pseudo-hochgradigen LGAS (PS-LGAS) zugeteilt. Alle Patientendaten wurden manuell ausgewertet. Das klinische Follow Up fand frühestens ein Jahr nach der DSE statt und bestand aus einem Telefoninterview oder einer klinischen Untersuchung. Ergebnisse: Die DSE ist zur Diagnose einer TS-LGAS bei Patienten mit einer erhaltenen LVEF von großem Nutzen. Die in der TTE gemessene AVA ist ein unabhängiger Prädiktor für eine TS-LGAS bei Patienten mit erhaltener und reduzierter LVEF. Eine verringerte MAPSE und eine reduzierte TDI-s´ sprechen bei Patienten mit erhaltener LVEF für eine TS-LGAS. Bei Patienten mit reduzierter LVEF weisen ein erhöhter sPAP und eine verringerte AV Geschwindigkeits Ratio auf eine TS-LGAS hin. Bei Zweifeln können weitere bildgebende Verfahren zur Diagnosefindung hinzugezogen werden.
Diese retrospektive Studie an der Universitätsklinik Würzburg diente der Beurteilung der longitudinalen Funktion in Bezug auf die Gesamtmortalität bei Patienten mit HFmrEF und HFrEF. Die Gruppierung erfolgte anhand der jeweiligen Baseline LVEF. Eine weitere Unterteilung erfolgte in eine ischämische oder nicht-ischämische Genese der HF. Die Subgruppen wurden anhand der Baseline klinischen Charakteristika sowie der echokardiographischen Parameter verglichen. Hier ließ sich ein relativ ähnliches Patientenklientel mit vergleichbarem Alter, Geschlecht, BMI sowie kardialen Risikofaktoren zeigen. Signifikante Unterschiede ergab der Vergleich des NYHA-Stadiums, der Nierenfunktion sowie des Auftretens von Myokardinfarkten.
Die Veränderung der LVEF über die Zeit hat einen zentralen Stellenwert zur Evaluation des Outcomes von Patienten mit HFmrEF und HFrEF. Eine Verbesserung der LVEF fand sich signifikant häufiger bei HFrEF Patienten als bei HFmrEF Patienten, welche über die Zeit signifikant häufiger eine stabile LVEF aufwiesen.
Außerdem war nach Auswertung der Überlebenskurven nach Kaplan-Meier in HFmrEF Patienten eine verbesserte oder unveränderte LVEF über die Zeit mit einem besseren Überleben verbunden, vor allem bei Patienten mit ischämischer Ätiologie. In der HFrEF Gruppe konnte gezeigt werden, dass sowohl Patienten mit ischämischer als auch mit nicht-ischämischer Ätiologie bei Vorliegen einer verbesserten oder unveränderten LVEF über die Zeit ein besseres Outcome aufwiesen.
Eine erniedrigte MAPSE bedeutete vor allem bei HFmrEF Patienten mit nicht-ischämischer Ätiologie ein schlechteres Outcome.
Die Ergebnisse dienten unter anderem der weiteren Charakterisierung der HFmrEF und HFrEF Gruppe sowie der Identifikation von Faktoren zur Beurteilung der Veränderung der LVEF über die Zeit und der Prognose des Langzeitüberlebens beider Gruppen. Ziel für die Zukunft sollte sein, auch für HFmrEF Patienten evidenzbasierte Herzinsuffizienz Therapien zu etablieren.
Hintergrund: Die therapeutischen Optionen für das gering differenzierte (PDTC) und anaplastische (ATC) Schilddrüsenkarzinom sind limitiert, weshalb diese Erkrankungen überwiegend mit einer schlechten Prognose einhergehen. Lenvatinib (LEN) ist ein Multityrosinkinase-Inhibitor, der unter anderem die Fibroblasten-Wachstumsfaktor-Rezeptoren (FGFR) 1-4 inhibiert und zur Therapie des fortgeschrittenen radiojodrefraktären Schilddrüsenkarzinoms zugelassen ist. Es zeigt sich nur ein geringes Ansprechen auf die Monotherapie bei ATCs, wobei neuere Studien eine therapeutische Überlegenheit der Kombination aus LEN und dem PD-1-Inhibitor Pembrolizumab (PEM) beschreiben.
Material und Methoden: Die Expression von PD-L1 wurde in ATC (n=93)- und PDTC (n=47)-Primärtumorgewebe von 1997-2019 aus fünf deutschen (Universitäts-)Kliniken mittels Immunhistochemie analysiert und mit dem Tumor Proportion Score (TPS) quantifiziert. Der Nachweis von FGFR1-4-mRNA wurde bei 31 ATC- und 14 PDTC-Gewebeproben mittels RNAscope In-situ-Hybridisierung quantifiziert. Als Kontrollgruppe wurde normales Schilddrüsengewebe (NT) und Gewebe von papillären Schilddrüsenkarzinomen (PTC) verwendet. Der primäre Endpunkt war das krankheitsspezifische Überleben (DSS).
Ergebnisse: Eine PD-L1-Expression mit einem TPS ≥50% konnte in 42% der ATC- und in 26% der PDTC-Proben nachgewiesen werden. Die mediane PD-L1-Expression war in ATC-(TPS 30%) signifikant höher im Vergleich zu PDTC-Proben (5%; p<0,01) und NT (0%; p<0,001). 53% der PDTC-Proben zeigten eine PD-L1-Expression ≤5%. Die Expression von FGFR-mRNA war in allen Proben sehr gering, wobei die kombinierte FGFR1-4-Expression in PDTC- und ATC-Gewebe im Vergleich zu normalem Schilddrüsengewebe signifikant höher war (jeweils p<0,001). Es ergab sich keine Assoziation zwischen der PD-L1- und FGFR1-4-Expression mit dem krankheitsspezifischen Überleben.
Schlussfolgerung: Eine hohe PD-L1-Expression in einem großen Anteil der ATCs und einem Viertel der PDTCs, könnte auf eine Rationale zur Therapieentscheidung für Immuncheckpoint-Inhibioren hinweisen. Die FGFR-Expression war in allen Schilddrüsenkarzinomen sehr gering. Der klinisch beobachtete Synergismus von PEM und LEN könnte durch immunmodulatorische Effekte hervorgerufen werden.
Ultra-high field cardiac MRI in large animals and humans for translational cardiovascular research
(2023)
A key step in translational cardiovascular research is the use of large animal models to better understand normal and abnormal physiology, to test drugs or interventions, or to perform studies which would be considered unethical in human subjects. Ultrahigh field magnetic resonance imaging (UHF-MRI) at 7 T field strength is becoming increasingly available for imaging of the heart and, when compared to clinically established field strengths, promises better image quality and image information content, more precise functional analysis, potentially new image contrasts, and as all in-vivo imaging techniques, a reduction of the number of animals per study because of the possibility to scan every animal repeatedly. We present here a solution to the dual use problem of whole-body UHF-MRI systems, which are typically installed in clinical environments, to both UHF-MRI in large animals and humans. Moreover, we provide evidence that in such a research infrastructure UHF-MRI, and ideally combined with a standard small-bore UHF-MRI system, can contribute to a variety of spatial scales in translational cardiovascular research: from cardiac organoids, Zebra fish and rodent hearts to large animal models such as pigs and humans. We present pilot data from serial CINE, late gadolinium enhancement, and susceptibility weighted UHF-MRI in a myocardial infarction model over eight weeks. In 14 pigs which were delivered from a breeding facility in a national SARS-CoV-2 hotspot, we found no infection in the incoming pigs. Human scanning using CINE and phase contrast flow measurements provided good image quality of the left and right ventricle. Agreement of functional analysis between CINE and phase contrast MRI was excellent. MRI in arrested hearts or excised vascular tissue for MRI-based histologic imaging, structural imaging of myofiber and vascular smooth muscle cell architecture using high-resolution diffusion tensor imaging, and UHF-MRI for monitoring free radicals as a surrogate for MRI of reactive oxygen species in studies of oxidative stress are demonstrated. We conclude that UHF-MRI has the potential to become an important precision imaging modality in translational cardiovascular research.
Purpose: This study analyses a large number of cancer patients with CIEDs for device malfunction and premature battery depletion by device interrogation after each radiotherapy fraction and compares different guidelines in regard to patient safety. Methods: From 2007 to 2022, a cohort of 255 patients was analyzed for CIED malfunctions via immediate device interrogation after every RT fraction. Results: Out of 324 series of radiotherapy treatments, with a total number of 5742 CIED interrogations, nine device malfunctions (2.8%) occurred. Switching into back-up/safety mode and software errors occurred four times each. Once, automatic read-out could not be performed. The median prescribed cumulative dose at planning target volume (PTV) associated with CIED malfunction was 45.0 Gy (IQR 36.0–64.0 Gy), with a median dose per fraction of 2.31 Gy (IQR 2.0–3.0 Gy). The median maximum dose at the CIED at time of malfunction was 0.3 Gy (IQR 0.0–1.3 Gy). No correlation between CIED malfunction and maximum photon energy (p = 0.07), maximum dose at the CIED (p = 0.59) nor treatment localization (p = 0.41) could be detected. After excluding the nine malfunctions, premature battery depletion was only observed three times (1.2%). Depending on the national guidelines, 1–9 CIED malfunctions in this study would have been detected on the day of occurrence and in none of the cases would patient safety have been compromised. Conclusion: Radiation-induced malfunctions of CIEDs and premature battery depletion are rare. If recommendations of national safety guidelines are followed, only a portion of the malfunctions would be detected directly after occurrence. Nevertheless, patient safety would not be compromised.
Air pollution is associated with morbidity and mortality worldwide. We investigated the impact of improved air quality during the economic lockdown during the SARS-Cov2 pandemic on emergency room (ER) admissions in Germany. Weekly aggregated clinical data from 33 hospitals were collected in 2019 and 2020. Hourly concentrations of nitrogen and sulfur dioxide (NO2, SO2), carbon and nitrogen monoxide (CO, NO), ozone (O3) and particulate matter (PM10, PM2.5) measured by ground stations and meteorological data (ERA5) were selected from a 30 km radius around the corresponding ED. Mobility was assessed using aggregated cell phone data. A linear stepwise multiple regression model was used to predict ER admissions. The average weekly emergency numbers vary from 200 to over 1600 cases (total n = 2,216,217). The mean maximum decrease in caseload was 5 standard deviations. With the enforcement of the shutdown in March, the mobility index dropped by almost 40%. Of all air pollutants, NO2 has the strongest correlation with ER visits when averaged across all departments. Using a linear stepwise multiple regression model, 63% of the variation in ER visits is explained by the mobility index, but still 6% of the variation is explained by air quality and climate change.
Psychosocial factors affect mental health and health-related quality of life (HRQL) in a complex manner, yet gender differences in these interactions remain poorly understood. We investigated whether psychosocial factors such as social support and personal and work-related concerns impact mental health and HRQL differentially in women and men during the first year of the COVID-19 pandemic. Between June and October 2020, the first part of a COVID-19-specific program was conducted within the “Characteristics and Course of Heart Failure Stages A-B and Determinants of Progression (STAAB)” cohort study, a representative age- and gender-stratified sample of the general population of Würzburg, Germany. Using psychometric networks, we first established the complex relations between personal social support, personal and work-related concerns, and their interactions with anxiety, depression, and HRQL. Second, we tested for gender differences by comparing expected influence, edge weight differences, and stability of the networks. The network comparison revealed a significant difference in the overall network structure. The male (N = 1370) but not the female network (N = 1520) showed a positive link between work-related concern and anxiety. In both networks, anxiety was the most central variable. These findings provide further evidence that the complex interplay of psychosocial factors with mental health and HRQL decisively depends on gender. Our results are relevant for the development of gender-specific interventions to increase resilience in times of pandemic crisis.