Refine
Year of publication
Document Type
- Doctoral Thesis (8964)
- Journal article (8586)
- Complete part of issue (703)
- Book article / Book chapter (479)
- Book (218)
- Conference Proceeding (202)
- Preprint (130)
- Review (115)
- Master Thesis (105)
- Working Paper (105)
Language
- English (11113)
- German (8628)
- French (58)
- Multiple languages (22)
- Spanish (22)
- Russian (6)
- Italian (2)
- Portuguese (2)
Keywords
- Würzburg (739)
- Universität (668)
- Wuerzburg (668)
- Wurzburg (660)
- University (608)
- Organische Chemie (135)
- Psychologie (128)
- Anorganische Chemie (124)
- Maus (124)
- Toxikologie (123)
- Medizin (111)
- inflammation (108)
- apoptosis (105)
- Signaltransduktion (104)
- Deutschland (100)
- Genexpression (99)
- Taufliege (93)
- cancer (89)
- Biochemie (87)
- gene expression (81)
- Apoptosis (79)
- MRI (77)
- T-Lymphozyt (76)
- depression (75)
- Chemie (74)
- Tissue Engineering (73)
- Drosophila (72)
- Jahresbericht (71)
- Herzinsuffizienz (67)
- children (66)
- HIV (65)
- boron (64)
- Depression (62)
- Thrombozyt (62)
- therapy (62)
- Apoptose (60)
- COVID-19 (60)
- NMR-Tomographie (60)
- Biologie (59)
- Dendritische Zelle (58)
- Infektionsbiologie (58)
- Molekularbiologie (57)
- expression (57)
- oxidative stress (57)
- Bericht (56)
- Kernspintomografie (56)
- Kind (55)
- Escherichia coli (54)
- ADHD (53)
- Neurobiologie (53)
- breast cancer (53)
- machine learning (53)
- multiple myeloma (53)
- Diabetes mellitus (52)
- Molekulargenetik (52)
- Physiologische Chemie (51)
- Rezension (51)
- Candida albicans (50)
- Drosophila melanogaster (50)
- Krebs <Medizin> (50)
- Lebensqualität (50)
- Melanom (50)
- Annual Report (49)
- Immunologie (49)
- Neisseria meningitidis (49)
- infection (49)
- Bor (48)
- Hadron-Hadron scattering (experiments) (48)
- melanoma (48)
- virtual reality (48)
- Aspergillus fumigatus (47)
- Herzinfarkt (47)
- Schizophrenie (47)
- Staphylococcus aureus (47)
- Therapie (47)
- heart failure (47)
- Entzündung (46)
- Simulation (46)
- Transkriptionsfaktor (46)
- Tumor (46)
- anxiety (46)
- metabolism (46)
- stroke (46)
- Geschichte (45)
- Topologischer Isolator (45)
- cytokines (45)
- myocardial infarction (45)
- Ackerschmalwand (44)
- Schlaganfall (44)
- T cells (44)
- Universitätsbibliothek (44)
- remote sensing (44)
- Biomarker (43)
- Brustkrebs (43)
- Germany (43)
- Zeitschrift (43)
- biomarker (43)
- magnetic resonance imaging (43)
- mice (43)
- multiple sclerosis (43)
- Genregulation (42)
- Plasmozytom (42)
- Ratte (42)
- dendritic cells (42)
- platelets (42)
- EEG (41)
- Oxidativer Stress (41)
- PET (41)
- signal transduction (41)
- DNA damage (40)
- Report (40)
- Rezeptor (40)
- prostate cancer (40)
- quality of life (40)
- Fluoreszenz (39)
- Multiples Myelom (39)
- SARS-CoV-2 (39)
- University Library (39)
- Virologie (39)
- Zellkultur (39)
- evolution (39)
- in vitro (39)
- ischemic stroke (39)
- Calcium (38)
- Evolution (38)
- Multiple Sklerose (38)
- Stammzelle (38)
- Angst (37)
- Serotonin (37)
- Strahlentherapie (37)
- climate change (37)
- fluorescence (37)
- Chemische Synthese (36)
- China (36)
- Entwicklung (36)
- Fabry disease (36)
- Immuntherapie (36)
- Spektroskopie (36)
- biodiversity (36)
- Biene (35)
- Chirurgie (35)
- Immunsystem (35)
- MRT (35)
- Zelldifferenzierung (35)
- brain (35)
- differentiation (35)
- macrophages (35)
- mouse (35)
- obesity (35)
- Antikörper (34)
- Arteriosklerose (34)
- Endothel (34)
- Jugend (34)
- genetics (34)
- prognosis (34)
- schizophrenia (34)
- tissue engineering (34)
- Arabidopsis thaliana (33)
- Blut-Hirn-Schranke (33)
- DNA (33)
- Einzelhandel (33)
- Nanopartikel (33)
- Quantenpunkt (33)
- Stress (33)
- Supramolekulare Chemie (33)
- deep learning (33)
- pain (33)
- phosphorylation (33)
- Bayern (32)
- Deutsch (32)
- Lernen (32)
- Molekularstrahlepitaxie (32)
- Regulation (32)
- Schmerz (32)
- Selbstorganisation (32)
- diagnosis (32)
- gene (32)
- rat (32)
- Modellierung (31)
- Proliferation (31)
- Zellzyklus (31)
- heart (31)
- mortality (31)
- Adipositas (30)
- CXCR4 (30)
- Herz (30)
- Inhibitor (30)
- Kinder (30)
- Maschinelles Lernen (30)
- Universität Würzburg (30)
- immunotherapy (30)
- protein (30)
- survival (30)
- ADHS (29)
- Aufmerksamkeit (29)
- B cells (29)
- Fernerkundung (29)
- Fluoreszenzmikroskopie (29)
- Genetik (29)
- Leistungsbewertung (29)
- Masernvirus (29)
- Photoelektronenspektroskopie (29)
- Positronen-Emissions-Tomografie (29)
- Proteine (29)
- Silicium (29)
- Virulenz (29)
- radiotherapy (29)
- regulatory T cells (29)
- stem cells (29)
- DNS-Reparatur (28)
- Elektrophysiologie (28)
- Epigenetik (28)
- Exziton (28)
- Immunsuppression (28)
- Malaria (28)
- Microarray (28)
- Parkinson-Krankheit (28)
- Polymere (28)
- Trypanosoma brucei (28)
- atherosclerosis (28)
- mouse model (28)
- surgery (28)
- Angiogenese (27)
- DNA methylation (27)
- Gehirn (27)
- Mensch (27)
- Sprachentwicklung (27)
- Stickstoffmonoxid (27)
- identification (27)
- mitochondria (27)
- positron emission tomography (27)
- proliferation (27)
- Archäologie (26)
- Bioinformatik (26)
- Cytokine (26)
- High energy physics (26)
- Human-Animal Studies (26)
- Immunreaktion (26)
- Infektion (26)
- Inhibition (26)
- Klimaänderung (26)
- MAP-Kinase (26)
- Makrophage (26)
- Migration (26)
- Myc (26)
- Myokardinfarkt (26)
- Parkinson's disease (26)
- RNA (26)
- Raman-Spektroskopie (26)
- autophagy (26)
- bone (26)
- chronic kidney disease (26)
- dSTORM (26)
- endothelial cells (26)
- learning (26)
- microRNA (26)
- physics (26)
- virulence (26)
- 3D printing (25)
- Bakterien (25)
- DNS-Schädigung (25)
- Environmental Humanities (25)
- Kognition (25)
- Literary Studies (25)
- Mikroskopie (25)
- Organischer Halbleiter (25)
- Parton Distributions (25)
- Polymorphismus (25)
- Prognose (25)
- Rezidiv (25)
- Schwertkärpfling (25)
- Verhalten (25)
- artificial intelligence (25)
- blood (25)
- epidemiology (25)
- medicine (25)
- mesenchymal stem cells (25)
- migration (25)
- regulation (25)
- resistance (25)
- Aminosäuren (24)
- Animal Studies (24)
- Atherosklerose (24)
- Aufsatzsammlung (24)
- BMP (24)
- Biofilm (24)
- Cultural Animal Studies (24)
- Cultural Studies (24)
- Ecocriticism (24)
- Fettsucht (24)
- Halbleiter (24)
- Knochenzement (24)
- Literatur (24)
- Pharmakokinetik (24)
- Tiermodell (24)
- Vaccinia-Virus (24)
- Virtuelle Realität (24)
- behavior (24)
- development (24)
- immunohistochemistry (24)
- miRNS (24)
- neuroinflammation (24)
- self-assembly (24)
- 3D-Druck (23)
- Autoantikörper (23)
- BDNF (23)
- Cancer (23)
- Glioblastom (23)
- Inflammation (23)
- Knockout <Molekulargenetik> (23)
- Listeria monocytogenes (23)
- Motoneuron (23)
- NMR-Bildgebung (23)
- Parkinson’s disease (23)
- Zytokine (23)
- activation (23)
- attention (23)
- classification (23)
- colorectal cancer (23)
- cytotoxicity (23)
- disease (23)
- human (23)
- measles virus (23)
- recurrence (23)
- transcription (23)
- treatment (23)
- Diagnostik (22)
- Differenzierung (22)
- Expression (22)
- GPCR (22)
- Gedächtnis (22)
- Genanalyse (22)
- Hydrogel (22)
- Optimierung (22)
- P300 (22)
- Pflanzen (22)
- Screening (22)
- antibodies (22)
- cAMP (22)
- calcium (22)
- chemotherapy (22)
- emotion (22)
- extracellular matrix (22)
- follow-up (22)
- hippocampus (22)
- imaging (22)
- memory (22)
- osteoporosis (22)
- perception (22)
- physical activity (22)
- toxicity (22)
- validation (22)
- Angststörung (21)
- Chemotherapie (21)
- Dickdarmkrebs (21)
- Evaluation (21)
- Fabry-Krankheit (21)
- Gefühl (21)
- Glaukom (21)
- HPLC (21)
- In vitro (21)
- Knochen-Morphogenese-Proteine (21)
- Kollagen (21)
- LHC (21)
- Organische Synthese (21)
- Osteoporose (21)
- Synapse (21)
- T-Zellen (21)
- TRAIL (21)
- adrenocortical carcinoma (21)
- blood-brain barrier (21)
- cytoskeleton (21)
- deep brain stimulation (21)
- neuropathic pain (21)
- receptor (21)
- serotonin (21)
- stress (21)
- transcriptome (21)
- Übergangsmetallkomplexe (21)
- ATLAS detector (20)
- Apis mellifera (20)
- Aufmerksamkeits-Defizit-Syndrom (20)
- Borylene (20)
- Computersimulation (20)
- Erziehung (20)
- Hippocampus (20)
- Insulin (20)
- Legionella pneumophila (20)
- Lunge (20)
- Mausmodell (20)
- NFATc1 (20)
- NMR-Spektroskopie (20)
- Synthese (20)
- angiogenesis (20)
- binding (20)
- flow cytometry (20)
- honeybee (20)
- metastasis (20)
- mutation (20)
- risk factors (20)
- topological insulators (20)
- transcription factors (20)
- Ameisen (19)
- Antibiotikum (19)
- Cytologie (19)
- Fragebogen (19)
- Genmutation (19)
- HIV-Infektion (19)
- Herzmuskel (19)
- Julius-Maximilians-Universität Würzburg (19)
- Metabolismus (19)
- Palliativmedizin (19)
- Prostatakrebs (19)
- Quecksilbertellurid (19)
- Rezeption (19)
- Sonderpädagogik (19)
- Stoffwechsel (19)
- TNF (19)
- annual report (19)
- antibiotics (19)
- biology (19)
- cell death (19)
- dopamine (19)
- echocardiography (19)
- epigenetics (19)
- fMRI (19)
- foraging (19)
- immune response (19)
- land use (19)
- lymphoma (19)
- management (19)
- mass spectrometry (19)
- miRNA (19)
- mouse models (19)
- p53 (19)
- pregnancy (19)
- psychology (19)
- sepsis (19)
- theranostics (19)
- transplantation (19)
- Actin (18)
- Autoimmunität (18)
- B-Lymphozyt (18)
- Bildgebendes Verfahren (18)
- Biomechanik (18)
- Boron (18)
- DNS (18)
- EAE (18)
- Europäische Union (18)
- Farbstoff (18)
- G-Protein gekoppelte Rezeptoren (18)
- Herzfrequenzvariabilität (18)
- Herzhypertrophie (18)
- Kaliumkanal (18)
- Krebs (18)
- MRSA (18)
- Neisseria gonorrhoeae (18)
- Netzwerk (18)
- Neurodegeneration (18)
- Niere (18)
- Optische Spektroskopie (18)
- Prävention (18)
- Resistenz (18)
- Ultraschall (18)
- Virulenzfaktor (18)
- active zone (18)
- aging (18)
- ants (18)
- autoimmunity (18)
- bacteria (18)
- crystal structure (18)
- diabetes (18)
- in vivo (18)
- kidney (18)
- luminescence (18)
- neuroprotection (18)
- outcome (18)
- platelet (18)
- polymorphism (18)
- proteins (18)
- spectroscopy (18)
- time series (18)
- ARPES (17)
- Arzneimitteldesign (17)
- Biodiversität (17)
- Biomaterial (17)
- DFT (17)
- DNA repair (17)
- Endothelzelle (17)
- Fluoreszenz-Resonanz-Energie-Transfer (17)
- Fremdsprachenunterricht (17)
- Fuchsbandwurm (17)
- Helicobacter pylori (17)
- Immunmodulation (17)
- Interaktion (17)
- MODIS (17)
- MYC (17)
- Makrophagen (17)
- Masern (17)
- Merkel cell carcinoma (17)
- Methylierung (17)
- Molekulardynamik (17)
- Motivation (17)
- Mutation (17)
- NIR-Spektroskopie (17)
- Nachhaltigkeit (17)
- Naphthylisochinolinalkaloide (17)
- Neurogenese (17)
- PET/CT (17)
- Photolumineszenz (17)
- Plattenepithelcarcinom (17)
- Polyneuropathie (17)
- Pädiatrie (17)
- Regulatorischer T-Lymphozyt (17)
- Rheumatoide Arthritis (17)
- Sepsis (17)
- Sol-Gel-Verfahren (17)
- Spinale Muskelatrophie (17)
- Tanzania (17)
- Wirkstoff (17)
- Zellmigration (17)
- Zellskelett (17)
- bees (17)
- biomarkers (17)
- bipolar disorder (17)
- blood pressure (17)
- diabetes mellitus (17)
- epithelial cells (17)
- event-related potentials (17)
- fibrosis (17)
- gene regulation (17)
- genotoxicity (17)
- immunosuppression (17)
- innate immunity (17)
- ischemia (17)
- lung cancer (17)
- mental health (17)
- messenger RNA (17)
- metagenomics (17)
- nitric oxide (17)
- simulation (17)
- structure elucidation (17)
- tumor (17)
- B-Zell-Lymphom (16)
- Bavaria (16)
- Decay (16)
- Dendritische Zellen (16)
- Digitalisierung (16)
- Embryonalentwicklung (16)
- Emotion (16)
- Festkörperphysik (16)
- Fremdsprachenlernen (16)
- Galliumarsenid (16)
- Heart failure (16)
- Hypertonie (16)
- Konditionierung (16)
- Kongress (16)
- Künstliche Intelligenz (16)
- Ligand <Biochemie> (16)
- Magnetresonanztomographie (16)
- Monte-Carlo-Simulation (16)
- Muscarinrezeptor (16)
- Namibia (16)
- RNS (16)
- ROS (16)
- Spintronik (16)
- Stammzelltransplantation (16)
- T-cells (16)
- Thrombose (16)
- Ultrakurzzeitspektroskopie (16)
- actin (16)
- additive manufacturing (16)
- asthma (16)
- cells (16)
- diborenes (16)
- enzyme replacement therapy (16)
- hemodialysis (16)
- insects (16)
- mRNA (16)
- malaria (16)
- metabolomics (16)
- model (16)
- monocytes (16)
- neurodegeneration (16)
- neurons (16)
- nutrition (16)
- olfaction (16)
- ovarian cancer (16)
- prevalence (16)
- prevention (16)
- supramolecular chemistry (16)
- vision (16)
- Ökologie (16)
- 1 (15)
- Abscisinsäure (15)
- Aldosteron (15)
- Allergie (15)
- Bestrahlung (15)
- Colonkrebs (15)
- Cyclo-AMP (15)
- Dichtefunktionalformalismus (15)
- Diffusion (15)
- Drei-Fünf-Halbleiter (15)
- Dünne Schicht (15)
- Echinococcus (15)
- Extension (15)
- Femtosekundenspektroskopie (15)
- Halbleiterlaser (15)
- Impfung (15)
- Implantat (15)
- Ischämie (15)
- Kernspintomographie (15)
- Kontrastmittel (15)
- Maligne Hyperthermie (15)
- Massenspektrometrie (15)
- Medicine (15)
- Merocyanine (15)
- Mitochondrium (15)
- NMR (15)
- Nanostruktur (15)
- Nebenniere (15)
- Onkologie (15)
- Optimale Kontrolle (15)
- Organische Solarzelle (15)
- Phosphorylierung (15)
- Polymerase-Kettenreaktion (15)
- Prostatakarzinom (15)
- Rastertunnelmikroskopie (15)
- Romanistik (15)
- Sentinel-2 (15)
- Supersymmetry (15)
- Säugling (15)
- Therapeutisches Drug Monitoring (15)
- Transcription (15)
- Transforming Growth Factor beta (15)
- Transkription (15)
- Tumor-Nekrose-Faktor (15)
- Unterfranken (15)
- Wundheilung (15)
- Xiphophorus (15)
- association (15)
- cardiac hypertrophy (15)
- conservation (15)
- dendritic cell (15)
- diversity (15)
- ecology (15)
- escherichia coli (15)
- exercise (15)
- fracture (15)
- glaucoma (15)
- growth (15)
- hadron-hadron scattering (15)
- hypertension (15)
- inhibition (15)
- microscopy (15)
- mushroom body (15)
- optogenetics (15)
- pancreatic cancer (15)
- performance (15)
- prediction (15)
- prefrontal cortex (15)
- proton-proton collision (15)
- rheumatoid arthritis (15)
- synthesis (15)
- Übergangsmetall (15)
- Activation (14)
- Aggregation (14)
- Alter Orient (14)
- Alzheimer-Krankheit (14)
- Arzneimittel (14)
- Aufmerksamkeitsdefizit-Syndrom (14)
- Calciumphosphat (14)
- Chemokine (14)
- Chlamydia trachomatis (14)
- Chronische Herzinsuffizienz (14)
- Datennetz (14)
- Diabetes (14)
- Einzelmolekülmikroskopie (14)
- Elektroencephalogramm (14)
- Europarecht (14)
- Extrazelluläre Matrix (14)
- Fanconi-Anämie (14)
- Furcht (14)
- Guanylatcyclase (14)
- HNSCC (14)
- Herzchirurgie (14)
- HgTe (14)
- Higgs boson (14)
- Hämodialyse (14)
- Informationsverarbeitung (14)
- Invasion (14)
- Ionenkanal (14)
- Katalyse (14)
- Kernhülle (14)
- Kolonkarzinom (14)
- Koronare Herzkrankheit (14)
- Kulturanthropologie (14)
- Lehrerbildung (14)
- Lungenkrebs (14)
- Lymphozyt (14)
- MSC (14)
- Mammakarzinom (14)
- Meiose (14)
- Mitose (14)
- Monoklonaler Antikörper (14)
- NHC (14)
- Natürliche Killerzelle (14)
- Nervenzelle (14)
- Optischer Resonator (14)
- PSMA (14)
- Parkinson (14)
- Perylenderivate (14)
- Plasmodium falciparum (14)
- Reaktivität (14)
- Real time quantitative PCR (14)
- Rehabilitation (14)
- Remodeling (14)
- Robotik (14)
- SPECT (14)
- Sekundärmetabolit (14)
- Spumaviren (14)
- Strukturaufklärung (14)
- Tansania (14)
- Theoretische Chemie (14)
- Topologie (14)
- Transkription <Genetik> (14)
- Transplantation (14)
- West Africa (14)
- Zelle (14)
- Zwei-Sechs-Halbleiter (14)
- biofabrication (14)
- borylation (14)
- case report (14)
- cell cycle (14)
- chemistry (14)
- circadian clock (14)
- cultural studies (14)
- ecosystem services (14)
- evaluation (14)
- fNIRS (14)
- glioblastoma (14)
- guidelines (14)
- honey bees (14)
- in-vitro (14)
- in-vivo (14)
- inorganic chemistry (14)
- insulin (14)
- lymphocytes (14)
- mechanisms (14)
- melt electrowriting (14)
- nanoparticles (14)
- neutrophils (14)
- pharmacokinetics (14)
- photoelectron spectroscopy (14)
- quantum dot (14)
- reconstruction (14)
- rehabilitation (14)
- risk (14)
- sphingolipids (14)
- super-resolution microscopy (14)
- symbiosis (14)
- vaccinia virus (14)
- AIDS (13)
- ARDS (13)
- Alter (13)
- Alzheimerkrankheit (13)
- Angiotensin II (13)
- Arbeitsgedächtnis (13)
- Aspergillose (13)
- Aspergillus (13)
- Asthma (13)
- Bibliographie (13)
- CRISPR/Cas-Methode (13)
- Candida (13)
- Computertomographie (13)
- Cytotoxizität (13)
- Elektronischer Transport (13)
- Genotoxizität (13)
- Geographie (13)
- Globalisierung (13)
- Glucocorticosteroide (13)
- Heterocyclische Carbene <-N> (13)
- Heterostruktur (13)
- Hitzeschock-Proteine (13)
- Immunbiologie (13)
- Immunhistochemie (13)
- Insekten (13)
- Interferon (13)
- Komposit (13)
- Konfokale Mikroskopie (13)
- Lippen-Kiefer-Gaumenspalte (13)
- Literaturwissenschaft (13)
- Microscopy (13)
- Mittelalter (13)
- Morbus Fabry (13)
- NK cells (13)
- Neuronale Plastizität (13)
- Osteoarthritis (13)
- Perfusion (13)
- Physics (13)
- Physik (13)
- Psychiatrie (13)
- Quantifizierung (13)
- RNS-Interferenz (13)
- Risikofaktor (13)
- Schwangerschaft (13)
- Sphingolipide (13)
- Sprachwissenschaft (13)
- Stabilität (13)
- Supersymmetrie (13)
- Tumorzelle (13)
- VASP (13)
- VEGF (13)
- adolescents (13)
- age (13)
- amygdala (13)
- animal model (13)
- autoantibodies (13)
- cGMP (13)
- cardiomyopathy (13)
- cartilage (13)
- cell staining (13)
- cytokine (13)
- diet (13)
- fear conditioning (13)
- fungi (13)
- gender (13)
- humans (13)
- hypoxia (13)
- invasion (13)
- liver (13)
- meiosis (13)
- metaanalysis (13)
- micronuclei (13)
- molecular docking (13)
- mutations (13)
- neurology (13)
- osteoarthritis (13)
- panic disorder (13)
- perylene bisimide (13)
- preterm infants (13)
- proteomics (13)
- reliability (13)
- replication (13)
- safety (13)
- therapeutic drug monitoring (13)
- translation (13)
- traumatic brain injury (13)
- ubiquitin (13)
- vitamin D (13)
- vorsprachliche Entwicklung (13)
- working memory (13)
- zebrafish (13)
- Überleben (13)
- ALS (12)
- Adenosinrezeptor (12)
- Adhäsion (12)
- Altern (12)
- Arzneimittelüberwachung (12)
- Brain-derived neurotrophic factor (12)
- Click-Chemie (12)
- Comet Assay (12)
- Computer Center University of Wuerzburg (12)
- Dialyse (12)
- Diboren (12)
- Dopamin (12)
- Durchflusscytometrie (12)
- EGFR (12)
- ERP (12)
- Enzym (12)
- FRET (12)
- Fibrose (12)
- Fluorescence (12)
- Gen (12)
- Grundschule (12)
- Hirntumor (12)
- Immunotherapy (12)
- Kinderheilkunde (12)
- Klima (12)
- Klimawandel (12)
- Kohlenstoff-Nanoröhre (12)
- Komplikationen (12)
- Kulturwissenschaften (12)
- Kutikula (12)
- Lymphom (12)
- Magnetische Kernresonanz (12)
- Medienkompetenz (12)
- Metastase (12)
- Modell (12)
- Monitoring (12)
- NFAT (12)
- Nanostrukturiertes Material (12)
- Netzhaut (12)
- Nigeria (12)
- Non-Hodgkin-Lymphom (12)
- Onkogen (12)
- PCR (12)
- PRRT (12)
- Pharmakologie (12)
- Pilzkörper (12)
- Polytrauma (12)
- Quality of Experience (12)
- Quantenchemie (12)
- Rekonstruktion (12)
- Religion (12)
- Replikation (12)
- Rotatorenmanschette (12)
- Ruthenium (12)
- SMN (12)
- SNP (12)
- Schule (12)
- Siliciumorganische Verbindungen (12)
- Spracherwerb (12)
- Supraleitung (12)
- Toll-like-Rezeptoren (12)
- Tumor-Nekrose-Faktor <alpha> (12)
- Ubiquitin (12)
- Ultrakurzer Lichtimpuls (12)
- Validierung (12)
- Westafrika (12)
- Zelladhäsion (12)
- adhesion (12)
- antibody (12)
- blood–brain barrier (12)
- carbenes (12)
- catalysis (12)
- colorectal carcinoma (12)
- complications (12)
- database (12)
- dementia (12)
- drug delivery (12)
- dynamics (12)
- electronic properties and materials (12)
- emotions (12)
- endothelium (12)
- genome (12)
- genomics (12)
- head and neck cancer (12)
- heart rate (12)
- interaction (12)
- malignant hyperthermia (12)
- measles (12)
- mechanism (12)
- microarray (12)
- microbiome (12)
- molecular beam epitaxy (12)
- molecular biology (12)
- monoclonal antibodies (12)
- neuropathy (12)
- nuclear envelope (12)
- oncology (12)
- optimization (12)
- plasticity (12)
- pollen (12)
- pollination (12)
- polymers (12)
- rats (12)
- recombination (12)
- review (12)
- screening (12)
- synaptic plasticity (12)
- systematic review (12)
- thrombosis (12)
- tinnitus (12)
- topological insulator (12)
- total knee arthroplasty (12)
- trabeculectomy (12)
- tumor microenvironment (12)
- ultrasound (12)
- water oxidation (12)
- ++ (11)
- 3D (11)
- Alzheimer's disease (11)
- Alzheimer’s disease (11)
- Anorexia nervosa (11)
- Antigen CD8 (11)
- Arabidopsis (11)
- Atherosclerosis (11)
- B-Zelle (11)
- Bakterielle Infektion (11)
- Bioisosterie (11)
- Biosynthese (11)
- Bioverfügbarkeit (11)
- Blazar (11)
- Bruchpilot (11)
- CRISPR/Cas9 (11)
- Chromatin (11)
- Computertomografie (11)
- Dynamik (11)
- Elektronentransfer (11)
- Epidemiologie (11)
- Epidermaler Wachstumsfaktor-Rezeptor (11)
- Flavonoide (11)
- Fließverhalten (11)
- Fotovoltaik (11)
- Genom (11)
- Geschlecht (11)
- Handlungsorientierung (11)
- Hypoxie (11)
- Immuncytochemie (11)
- Immunology (11)
- Japankärpfling (11)
- Knochen (11)
- Knochenersatz (11)
- Kolorektales Karzinom (11)
- LASP1 (11)
- LPS (11)
- Laser (11)
- Längsschnittuntersuchung (11)
- MS (11)
- Mais (11)
- Mathematik (11)
- Megakaryozyt (11)
- Mensch-Maschine-Kommunikation (11)
- Mesenchymale Stammzellen (11)
- Mesenchymzelle (11)
- Model (11)
- Multiple Myeloma (11)
- Mutagenität (11)
- NIRS (11)
- Nanodiamant (11)
- Neuropathie (11)
- Niereninsuffizienz (11)
- Operation (11)
- Osteoinduktion (11)
- Parasit (11)
- Parathormon (11)
- Perylenbisimid (11)
- Phylogenie (11)
- Proteaseinhibitor (11)
- Proteasen (11)
- Psychotherapie (11)
- Pulmonale Hypertonie (11)
- Quality of life (11)
- Quanten-Hall-Effekt (11)
- Reperfusion (11)
- Risikofaktoren (11)
- Salmonella (11)
- Schizophrenia (11)
- Schlafapnoe (11)
- Schließzelle (11)
- Schultergelenk (11)
- Schädel-Hirn-Trauma (11)
- Silicate (11)
- Skala (11)
- Small RNA (11)
- Sprache (11)
- Squark (11)
- Stammzellen (11)
- Sterblichkeit (11)
- Symbiose (11)
- T cell (11)
- TWEAK (11)
- Training (11)
- Transplantat-Wirt-Reaktion (11)
- Tuberkelbakterium (11)
- USA (11)
- Vasodilatator-stimuliertes Phosphoprotein (11)
- Wahrnehmung (11)
- X-ray crystallography (11)
- Zebrabärbling (11)
- Zelltod (11)
- allergy (11)
- atrial fibrillation (11)
- biocompatibility (11)
- biofilm (11)
- cancer treatment (11)
- cell adhesion (11)
- clinical trial (11)
- cochlear implant (11)
- communication (11)
- coping (11)
- dosimetry (11)
- emotion regulation (11)
- fatigue (11)
- fear (11)
- fluorescence microscopy (11)
- glioblastoma multiforme (11)
- hydrogels (11)
- immunology (11)
- kinetics (11)
- lung (11)
- membrane proteins (11)
- microglia (11)
- molecular dynamics (11)
- molecular imaging (11)
- nervous system (11)
- neural networks (11)
- neuroendocrine tumor (11)
- next generation sequencing (11)
- oncolytic virus (11)
- periodontitis (11)
- phenotype (11)
- psychiatric disorders (11)
- randomized controlled trial (11)
- reactive oxygen species (11)
- relapse (11)
- signaling (11)
- tight junctions (11)
- transport (11)
- university (11)
- Alkohol (10)
- Antigen CD28 (10)
- BERA (10)
- BMP-2 (10)
- Bacteria (10)
- Bauchspeicheldrüsenkrebs (10)
- Beschichtung (10)
- Bildverarbeitung (10)
- Bioinformatics (10)
- Biokompatibilität (10)
- Borole (10)
- Cadherine (10)
- Calciumphosphate (10)
- Carbene (10)
- Children (10)
- Chronische Niereninsuffizienz (10)
- Churritisch (10)
- Cochlear-Implantat (10)
- Computational chemistry (10)
- Coronaviren (10)
- Covid-19 (10)
- Cyclo-GMP (10)
- Depressivität (10)
- Diamant (10)
- Digital Humanities (10)
- Dimerisierung (10)
- Dotierung (10)
- Echokardiographie (10)
- Eierstockkrebs (10)
- Elektrochemie (10)
- Elektronenkorrelation (10)
- Englisch (10)
- Enzyminhibitor (10)
- Erbkrankheit (10)
- Ereigniskorreliertes Potenzial (10)
- Erwachsener (10)
- Franken (10)
- Frau (10)
- Funktionalisierung <Chemie> (10)
- Funktionelle Kernspintomografie (10)
- Förderung (10)
- Geldpolitik (10)
- Glatter Krallenfrosch (10)
- Grenzfläche (10)
- HSM-Satztest (10)
- Herzmuskelzelle (10)
- Honigbiene (10)
- Hypophosphatasie (10)
- IL-4 (10)
- Immunfluoreszenz (10)
- Impfstoff (10)
- Induzierte pluripotente Stammzelle (10)
- Interleukin 4 (10)
- Interview (10)
- JNK (10)
- Klassifikation (10)
- Kleinsatellit (10)
- Kniegelenk (10)
- Kohlenstoff (10)
- Kommunikation (10)
- Komplikation (10)
- Kooperation (10)
- Kultur (10)
- LC-MS (10)
- Ladungstransfer (10)
- Ligand (10)
- Lokalisation (10)
- Magnesiumphosphate (10)
- Magnetismus (10)
- Mathematikunterricht (10)
- Mathematisches Modell (10)
- Medulloblastom (10)
- Metakognition (10)
- Metallocene (10)
- Methylphenidat (10)
- Mikrokerne (10)
- Musik (10)
- NAFLD (10)
- Nahrungserwerb (10)
- Nebennierenrindenkarzinom (10)
- Neolithikum (10)
- Neuropathischer Schmerz (10)
- Niger (10)
- Osteosynthese (10)
- PD-1 (10)
- PD-L1 (10)
- Pain (10)
- Panikstörung (10)
- Parodontitis (10)
- Pathogenität (10)
- Platelets (10)
- Plattenepithelkarzinom (10)
- Prevalence (10)
- Prostaglandine (10)
- Präfrontaler Cortex (10)
- Pädagogik (10)
- Qualitätskontrolle (10)
- RNA interference (10)
- RNA-seq (10)
- RNS-Spleißen (10)
- Radiotherapy (10)
- Remote Sensing (10)
- Rhodium (10)
- Rituximab (10)
- SAR (10)
- Schilddrüse (10)
- Sentinel-1 (10)
- Silaanaloga (10)
- Silber (10)
- Silicon (10)
- South Africa (10)
- Sprachverstehen (10)
- Staphylococcus (10)
- Starke Kopplung (10)
- Stickstoffmonoxid-Synthase (10)
- Stressreaktion (10)
- Stroke (10)
- Struktur (10)
- T-Lymphozyten (10)
- T-Lymphozyten-Rezeptor (10)
- Tagesrhythmus (10)
- Theologie (10)
- Totalsynthese (10)
- Toxizität (10)
- Transthorakale Echokardiographie (10)
- Treg (10)
- Trypanosomen (10)
- Verwaltungsrecht (10)
- Vitamin D (10)
- Vor- und Frühgeschichte (10)
- Vorschulkind (10)
- Wachstum (10)
- agriculture (10)
- aldosterone (10)
- amino acids (10)
- antimicrobial resistance (10)
- bariatric surgery (10)
- bioinformatics (10)
- biosynthesis (10)
- body size (10)
- boranes (10)
- cancer therapy (10)
- chemokines (10)
- chronic heart failure (10)
- circadian rhythms (10)
- cognitive impairment (10)
- collagen (10)
- comparison (10)
- complex (10)
- coronary artery disease (10)
- cortisol (10)
- decision-making (10)
- density functional calculations (10)
- eNOS (10)
- education (10)
- gene therapy (10)
- genome-wide association (10)
- glioma (10)
- global change (10)
- glycine receptor (10)
- human behaviour (10)
- immunomodulation (10)
- induced pluripotent stem cells (10)
- injury (10)
- insect (10)
- knockout (10)
- leaf-cutting ants (10)
- leukemia (10)
- lymph nodes (10)
- mapping (10)
- membrane potential (10)
- motivation (10)
- near-infrared spectroscopy (10)
- neuroscience (10)
- oncolytic virotherapy (10)
- oxidativer Stress (10)
- quality assurance (10)
- quantification (10)
- regulatorische T-Zellen (10)
- remodeling (10)
- senescence (10)
- silicon (10)
- social interaction (10)
- stem cell transplantation (10)
- subthalamic nucleus (10)
- synapse (10)
- tDCS (10)
- transcriptomics (10)
- tumors (10)
- vaccination (10)
- vertigo (10)
- walking (10)
- Östrogene (10)
- 3 (9)
- Adenosin (9)
- Adenosine receptors (9)
- Affekt (9)
- Afrika (9)
- Alps (9)
- Analyse (9)
- Angeregter Zustand (9)
- Anxiety (9)
- Aorta (9)
- Aortenstenose (9)
- Autophagie (9)
- Beyond Standard Model (9)
- Biotransformation (9)
- Bordetella pertussis (9)
- Borylierung (9)
- Boğazkale (9)
- Butyrat (9)
- CT (9)
- Carcinogenese (9)
- Catalysis (9)
- Chiralität <Chemie> (9)
- Cloud Computing (9)
- Deep learning (9)
- Dendritic cells (9)
- Diagnose (9)
- Diborane (9)
- Diskursanalyse (9)
- Dünndarm (9)
- Einzelphotonenemission (9)
- Elektroencephalographie (9)
- Elektronenmikroskopie (9)
- Elektronenstruktur (9)
- Elementarteilchenphysik (9)
- Epithel (9)
- Ernährung (9)
- Experimentelle Psychologie (9)
- Extremwertstatistik (9)
- Familie (9)
- Fanconi Anämie (9)
- Fettgewebe (9)
- Fibroblastenwachstumsfaktor (9)
- Fibromyalgie (9)
- Finite-Elemente-Methode (9)
- Frühgeborene (9)
- GIS (9)
- Geistigbehindertenpädagogik (9)
- Gentherapie (9)
- Geoinformationssystem (9)
- Geruchswahrnehmung (9)
- Glioblastoma (9)
- Google Earth Engine (9)
- Grammatik (9)
- Haut (9)
- Herzmuskelkrankheit (9)
- Hethiter (9)
- Hyaluronsäure (9)
- Immunisierung (9)
- Impulsivität (9)
- Innovation (9)
- Instrumentelle Analytik (9)
- Integrine (9)
- Iran (9)
- Isolierung <Chemie> (9)
- Jugendliche (9)
- Juvenile chronische Arthritis (9)
- Kapillarelektrophorese (9)
- Knorpel (9)
- Konflikt (9)
- Koordinationslehre (9)
- Korpus <Linguistik> (9)
- LC-MS/MS (9)
- Landsat (9)
- Leber (9)
- Linguistik (9)
- Löslichkeit (9)
- MAPK (9)
- Macrophage (9)
- Magnetische Resonanz (9)
- Mehrfachbindung (9)
- Mehrsprachigkeit (9)
- Messenger-RNS (9)
- Mice (9)
- Molekulare Erkennung (9)
- Monozyt (9)
- Morphologie (9)
- Mukoviszidose (9)
- Myokardprotektion (9)
- NO (9)
- NSCLC (9)
- Nebennierenrindenkrebs (9)
- Neuroinflammation (9)
- Nierentransplantation (9)
- Oberfläche (9)
- Oberflächenphysik (9)
- Optoelektronik (9)
- Pathogenese (9)
- Persönlichkeit (9)
- Pharmakotherapie (9)
- Photolumineszenzspektroskopie (9)
- Physiologie (9)
- Plasmamembran (9)
- Protein (9)
- Pseudomonas syringae (9)
- Psychoonkologie (9)
- Quantenmechanik (9)
- Rechenzentrum (9)
- Rechtsvergleich (9)
- Regeneration (9)
- Regionalentwicklung (9)
- Revision (9)
- Sarkoidose (9)
- Satellit (9)
- Schmalwand <Arabidopsis> (9)
- Schwindel (9)
- Schüttgut (9)
- Spin-Bahn-Wechselwirkung (9)
- Squaraine (9)
- Stathmin (9)
- Stereoselektive Synthese (9)
- Supply Chain Management (9)
- Syntax (9)
- Systembiologie (9)
- Südafrika (9)
- TDM (9)
- Textverstehen (9)
- Therapy (9)
- Tourismus (9)
- Trabekulektomie (9)
- Transplantat (9)
- Transport (9)
- Trypanosoma (9)
- Tumorantigen (9)
- Vakuole (9)
- Vergleich (9)
- Visuelle Aufmerksamkeit (9)
- Wurzel (9)
- Zellkern (9)
- Zentralnervensystem (9)
- Zinkselenid (9)
- actin cytoskeleton (9)
- adolescence (9)
- aggregation (9)
- amyotrophic lateral sclerosis (9)
- antennal lobe (9)
- anxiety disorders (9)
- aromaticity (9)
- astrocytes (9)
- biomechanics (9)
- blood brain barrier (9)
- bone cement (9)
- bone marrow (9)
- cardiac surgery (9)
- cardiovascular disease (9)
- cell culture (9)
- cell migration (9)
- cell wall (9)
- central nervous system (9)
- cerebrospinal fluid (9)
- chromatin (9)
- computed tomography (9)
- coronary heart disease (9)
- cuticular hydrocarbons (9)
- cystic fibrosis (9)
- cytotoxic T cells (9)
- decision making (9)
- dendritische Zellen (9)
- dialysis (9)
- dispersal (9)
- earth observation (9)
- electroencephalography (9)
- electron microscopy (9)
- electrophysiology (9)
- energy (9)
- experimental autoimmune encephalomyelitis (9)
- family (9)
- foamy virus (9)
- forest (9)
- gephyrin (9)
- glucose (9)
- high energy physics (9)
- hip (9)
- hyaluronic acid (9)
- hydrogel (9)
- impact (9)
- incidence (9)
- inhibitor (9)
- interferon (9)
- latency (9)
- macrophage (9)
- major depression (9)
- mechanotransduction (9)
- mesenchymale Stammzellen (9)
- metapopulation (9)
- methylation (9)
- mitosis (9)
- monitoring (9)
- monoklonale Antikörper (9)
- myocardium (9)
- navigation (9)
- neurogenesis (9)
- optical spectroscopy (9)
- organic chemistry (9)
- organic semiconductors (9)
- pathogens (9)
- pathway (9)
- perfusion (9)
- peripheral nervous system (9)
- permeability (9)
- personality (9)
- pharmacology (9)
- photocatalysis (9)
- platelet activation (9)
- platelet aggregation (9)
- prognostic factors (9)
- quantum dots (9)
- radiation (9)
- rectal cancer (9)
- reveals (9)
- selection (9)
- serum (9)
- sleep (9)
- spinal muscular atrophy (9)
- systematic uncertainty (9)
- temperature (9)
- tolerance (9)
- transcription factor (9)
- transient absorption (9)
- transmission (9)
- type 2 diabetes (9)
- vaccine (9)
- water (9)
- wound healing (9)
- Übersetzung (9)
- ATLAS (8)
- AdS-CFT-Korrespondenz (8)
- Adhärenz (8)
- Aggregat <Chemie> (8)
- Akt (8)
- Aktiver galaktischer Kern (8)
- Algorithmus (8)
- Alltagskultur (8)
- Ancistrocladaceae (8)
- Anthocyane (8)
- Antibiotika (8)
- Antigen (8)
- Antigen CD40 (8)
- Aortenklappenersatz (8)
- Arthrose (8)
- Arthroskopie (8)
- Arzneimittelforschung (8)
- Astrophysik (8)
- Asymmetrie (8)
- Asymmetrische Synthese (8)
- Auge (8)
- Autoaggressionskrankheit (8)
- Autonomer Roboter (8)
- Bauchspeicheldrüse (8)
- Biradikal (8)
- Blimp-1 (8)
- Blutdruck (8)
- Blutstammzelle (8)
- Botanik (8)
- Brain (8)
- Burkina Faso (8)
- CD28 (8)
- CD40 (8)
- CD95 (8)
- COMT (8)
- Caenorhabditis elegans (8)
- Camponotus floridanus (8)
- Chlamydia (8)
- Compressed Sensing (8)
- Cross-Section (8)
- Cysteinproteasen (8)
- Cytomegalie-Virus (8)
- DLBCL (8)
- Darm (8)
- Data Mining (8)
- Datenbank (8)
- Degradation (8)
- Demenz (8)
- Deutschunterricht (8)
- Diborene (8)
- ELISA (8)
- ERK (8)
- Elektronenspin (8)
- Elektronenspinresonanz (8)
- Emotionsregulation (8)
- Endothelzellen (8)
- Engagement (8)
- Erbrechen (8)
- Europa (8)
- Europe (8)
- Exziton-Polariton (8)
- Fachdidaktik (8)
- Femtosekundenbereich (8)
- Fibroblasten (8)
- Fitness (8)
- Fluoreszenzspektroskopie (8)
- Forschung (8)
- Fußball (8)
- GABA (8)
- Gammastrahlung (8)
- Gedächtnisleistung (8)
- Genotoxicity (8)
- Geschlechtsunterschied (8)
- Gewebe (8)
- Gliom (8)
- Graphen (8)
- HPLC-MS (8)
- Habichtskraut (8)
- Haemophilus influenzae (8)
- Harnwegsinfektion (8)
- Hernie (8)
- Hochbegabung (8)
- Hubbard-Modell (8)
- Humangenetik (8)
- Hymenoptera (8)
- Hypertrophie (8)
- Hüftgelenk (8)
- IL-10 (8)
- Immunantwort (8)
- In vivo (8)
- India (8)
- Indien (8)
- Inklusion (8)
- Keilschrifttext (8)
- Kephalometrie (8)
- Kieferorthopädie (8)
- Kinetik (8)
- Knochenersatzmaterial (8)
- Knockout (8)
- Komposit <Zahnmedizin> (8)
- Kondo-Effekt (8)
- Korrelation (8)
- Kreuzband (8)
- Kristallstruktur (8)
- Landwirtschaft (8)
- Langerhans-Inseln (8)
- Lanthanoide (8)
- Lehre (8)
- Leishmania (8)
- Lernautonomie (8)
- Lower Franconia (8)
- Lumineszenz (8)
- Lungenfibrose (8)
- Machine Learning (8)
- Magenbypass (8)
- Makuladegeneration (8)
- Mass (8)
- Meeresschwämme (8)
- Meiosis (8)
- Meningitis (8)
- Meningokokken (8)
- Metaanalyse (8)
- Methode (8)
- Mikroglia (8)
- Mikrokerntest (8)
- Mikrostruktur (8)
- Mitochondrien (8)
- Mobiler Roboter (8)
- Molekül (8)
- Monozyten (8)
- Multiple myeloma (8)
- Myokarditis (8)
- N-heterocyclic carbenes (8)
- Nachsorge (8)
- Nanodraht (8)
- Naturstoff (8)
- Neugeborenes (8)
- Neutrino (8)
- Notfallmedizin (8)
- Obesity (8)
- Onkolyse (8)
- Optogenetik (8)
- Organisches Molekül (8)
- Oxylipine (8)
- PONV (8)
- Pankreaskarzinom (8)
- Parton distributions (8)
- Pemphigus (8)
- Peptide (8)
- Periphere arterielle Verschlusskrankheit (8)
- Permeabilität (8)
- Pharmakodynamik (8)
- Photodissoziation (8)
- Photovoltaik (8)
- Platin (8)
- Pollen (8)
- Polycyclische Aromaten (8)
- Protein p53 (8)
- Protein-Tyrosin-Kinasen (8)
- Proteinbindung (8)
- Protonen-NMR-Spektroskopie (8)
- Präkonditionierung (8)
- Psychische Störung (8)
- Pump-Probe-Technik (8)
- Quantendynamik (8)
- Quelle (8)
- Quran (8)
- RNA sequencing (8)
- Radikal <Chemie> (8)
- Raf <Biochemie> (8)
- Raf-Kinasen (8)
- Raman spectroscopy (8)
- Rastertunnelmikroskop (8)
- Rechenzentrum Universität Würzburg (8)
- Rechnungslegung (8)
- Regenerative Medizin (8)
- Rekombination (8)
- Retroviren (8)
- Ringöffnungspolymerisation (8)
- Roman (8)
- Röntgen-Photoelektronenspektroskopie (8)
- Salmonella typhimurium (8)
- Schmerzforschung (8)
- Schwämme (8)
- Semimagnetischer Halbleiter (8)
- Siliciumcarbid (8)
- Sozialpsychologie (8)
- Sprachaudiometrie (8)
- Statistik (8)
- Stent (8)
- Stofftransport <Biologie> (8)
- Survival (8)
- Synthesis (8)
- T cell activation (8)
- T lymphocytes (8)
- T-Zelle (8)
- Tabak (8)
- Tagung (8)
- Text Mining (8)
- Textanalyse (8)
- Thrombosis (8)
- Thrombozyten (8)
- Thymus (8)
- Tight junction (8)
- Titan (8)
- Transkriptomanalyse (8)
- Trauma (8)
- Trypanosomiase (8)
- Tumorimmunologie (8)
- UAV (8)
- Ultraschalldiagnostik (8)
- Unterricht (8)
- Vascular endothelial Growth Factor (8)
- Virusinfektion (8)
- Visualisierung (8)
- Vulnerabilität (8)
- Wirkstofffreisetzung (8)
- Zahnmedizin (8)
- Zeitreihenanalyse (8)
- absorption (8)
- acute kidney injury (8)
- adaptation (8)
- adherence (8)
- adipose tissue (8)
- adults (8)
- ageing (8)
- aggression (8)
- allogeneic stem cell transplantation (8)
- analysis of variance (8)
- animal models (8)
- antigen (8)
- behaviour (8)
- bladder cancer (8)
- body mass index (8)
- borylene (8)
- calcium phosphate (8)
- cell biology (8)
- central complex (8)
- ceramide (8)
- charge transfer (8)
- chronic pain (8)
- classical conditioning (8)
- cleft lip and palate (8)
- coagulation (8)
- coherence (8)
- copper (8)
- crystallization (8)
- decay (8)
- distribution (8)
- division of labor (8)
- domain (8)
- dystonia (8)
- efficacy (8)
- electronic structure (8)
- embodiment (8)
- endocytosis (8)
- energy transfer (8)
- extinction (8)
- flavonoids (8)
- forest management (8)
- gastric cancer (8)
- genes (8)
- health-related quality of life (8)
- hearing (8)
- histology (8)
- immune evasion (8)
- implant (8)
- in vivo imaging (8)
- integrins (8)
- iron (8)
- jet energy scale (8)
- juvenile idiopathic arthritis (8)
- kinematic alignment (8)
- knee (8)
- learning and memory (8)
- lithium (8)
- mHealth (8)
- melt electrospinning writing (8)
- meta-analysis (8)
- methylphenidate (8)
- microbiology (8)
- microenvironment (8)
- microstructure (8)
- monocyte (8)
- morphology (8)
- mutualism (8)
- optimal control (8)
- organic solar cells (8)
- organoids (8)
- pancreas (8)
- pediatrics (8)
- permafrost (8)
- phylogeny (8)
- polycyclic aromatic hydrocarbons (8)
- preconditioning (8)
- presence (8)
- primary care (8)
- progression (8)
- protease (8)
- psoriasis (8)
- pulmonary hypertension (8)
- questionnaire (8)
- radicals (8)
- radioligand therapy (8)
- receptors (8)
- recovery (8)
- regenerative medicine (8)
- scaffold (8)
- secondary structure (8)
- secretion (8)
- semiconductor (8)
- shoulder (8)
- skin biopsy (8)
- smoking (8)
- social cognition (8)
- social insects (8)
- sodium (8)
- software (8)
- species richness (8)
- spintronics (8)
- staphylococcus aureus (8)
- structure (8)
- susceptibility (8)
- targeted therapy (8)
- technology (8)
- thymus (8)
- tool (8)
- transcriptional regulation (8)
- vestibular schwannoma (8)
- 3D tissue model (7)
- 53BP1 (7)
- Adsorption (7)
- Adulte Stammzelle (7)
- Africa (7)
- Aktin (7)
- Aktivierung (7)
- Aktivierung <Physiologie> (7)
- Akute myeloische Leukämie (7)
- Akutes Nierenversagen (7)
- Alzheimer disease (7)
- Anpassung (7)
- Antagonist (7)
- Anämie (7)
- Anästhesie (7)
- Audiologie (7)
- Audiometrie (7)
- Augmentation (7)
- Ausbreitung (7)
- Autoimmunity (7)
- B-Zellen (7)
- Behandlung (7)
- Behinderung (7)
- Bindungsaktivierung (7)
- Biographie (7)
- Blattschneiderameisen (7)
- Blut (7)
- Blutgerinnung (7)
- Bordetella (7)
- Borylenkomplexe (7)
- CMV (7)
- CNS (7)
- Calciumkanal (7)
- Candida auris (7)
- Catecholmethyltransferase <Catechol-0-Methyltransferase> (7)
- Charakterisierung (7)
- Charcot-Marie-Tooth (7)
- Chronobiologie (7)
- Chrysomelidae (7)
- Cisplatin (7)
- Coronavirus (7)
- Cytoskeleton (7)
- DHEA (7)
- DNS-Doppelstrangbruch (7)
- Deutsch als Fremdsprache (7)
- Didaktik (7)
- Differentielle Genexpression (7)
- Dopamine (7)
- Durchblutung (7)
- Durchflusszytometrie (7)
- Dysgnathie (7)
- E-Learning (7)
- ELISPOT (7)
- EMG (7)
- ERK1/2 (7)
- ERN (7)
- Echinococcus multilocularis (7)
- Einwandige Kohlenstoff-Nanoröhre (7)
- Eisen (7)
- Elektrokardiogramm (7)
- Embryo (7)
- Endoprothetik (7)
- Ethik (7)
- FISH (7)
- Fahrsimulator (7)
- Fanconi anemia (7)
- Festkörperoberfläche (7)
- Fibroblast (7)
- Fluoreszenz-in-situ-Hybridisierung (7)
- Flüssigkristall (7)
- Fortpflanzung (7)
- Fraktur (7)
- Freundschaft (7)
- Gallium (7)
- Gehirn-Computer-Schnittstelle (7)
- Geistige Behinderung (7)
- Gelenkknorpel (7)
- Genetics (7)
- Geochemie (7)
- Geologie (7)
- Geomorphologie (7)
- Geriatrie (7)
- Germanium (7)
- Geruch (7)
- Geruchssinn (7)
- Geschlechterforschung (7)
- Gesellschaftsrecht (7)
- Gewalt (7)
- Graft-versus-host-disease (7)
- Guillain-Barré-Syndrom (7)
- HIV-1 (7)
- HUVEC (7)
- Heart (7)
- Herzfrequenz (7)
- Hfq (7)
- High throughput screening (7)
- Histologie (7)
- Honeybee (7)
- Hyaliner Knorpel (7)
- Hypervalentes Molekül (7)
- Hämostase (7)
- Immunglobuline (7)
- Innenstadt (7)
- Integrin (7)
- Interleukin 6 (7)
- Internet (7)
- Jasmonate (7)
- KHK (7)
- Kandidatengen (7)
- Kardiologie (7)
- Kardiomyopathie (7)
- Karriere (7)
- Keramik (7)
- Keratinozyten (7)
- Kindheit (7)
- Kniegelenkprothese (7)
- Knieprothese (7)
- Knochenregeneration (7)
- Kohlenwasserstoffe (7)
- Komplement <Immunologie> (7)
- Komplexe (7)
- Koordinationspolymere (7)
- Koran (7)
- Kutikularwachs (7)
- LEED (7)
- Landnutzung (7)
- Langzeitergebnisse (7)
- Learning (7)
- Learning autonomy (7)
- Leishmaniose (7)
- Lernerautonomie (7)
- Lithium-Ionen-Akkumulator (7)
- Lungenfunktion (7)
- MBE (7)
- MYCN (7)
- Macht (7)
- Mangan (7)
- Manganarsenide (7)
- Mehragentensystem (7)
- Membranproteine (7)
- Metapopulation (7)
- Micronuclei (7)
- Mimik (7)
- Molekularbewegung (7)
- Monte Carlo (7)
- Monte-Carlo (7)
- Mortalität (7)
- Motilität (7)
- Motorisches Lernen (7)
- Mundschleimhaut (7)
- Museum (7)
- N-Myc (7)
- NDVI (7)
- Nash-Gleichgewicht (7)
- Naturstoffe (7)
- Neolithic (7)
- Nervendegeneration (7)
- Neuralgie (7)
- Neuroblastom (7)
- Neuroethologie (7)
- Neurootologie (7)
- Newton-Verfahren (7)
- Nicht-kleinzelliges Bronchialkarzinom (7)
- Nierenfunktion (7)
- Nierenversagen (7)
- Nierenzellkarzinom (7)
- Nuklearmedizin (7)
- Numerisches Verfahren (7)
- Ontogenie (7)
- Operations Management (7)
- Organisation (7)
- Outcome (7)
- Oxidation (7)
- Paniksyndrom (7)
- Parkinson disease (7)
- Performance Evaluation (7)
- Phagozytose (7)
- Pheromon (7)
- Photochemie (7)
- Photoionisation (7)
- Plasma (7)
- Promotor (7)
- Propofol (7)
- Proteinkinase C (7)
- Proteomanalyse (7)
- Pulsformung (7)
- Qualität (7)
- Qualitätssicherung (7)
- Quantenwell (7)
- REMPI (7)
- RNA-binding proteins (7)
- Radioastronomie (7)
- Raman (7)
- Ranvier-Schnürring (7)
- Rat (7)
- Rechtschreibung (7)
- Regulierung (7)
- Rheumatoid arthritis (7)
- Röntgenspektroskopie (7)
- SARS (7)
- SERS (7)
- SGLT1 (7)
- SMA (7)
- STAT3 (7)
- Saccharomyces cerevisiae (7)
- Sandwich-Verbindungen (7)
- Schilddrüsenkrebs (7)
- Schistosomiasis (7)
- Schmerztherapie (7)
- Schulleistung (7)
- Schulter (7)
- Siliciumdioxid (7)
- Soziale Insekten (7)
- Spanisch (7)
- Spin (7)
- Spintronics (7)
- Spiroergometrie (7)
- Stadtplanung (7)
- Steuerrecht (7)
- Strategisches Management (7)
- Struvit (7)
- Studie (7)
- Störlärm (7)
- Subarachnoidalblutung (7)
- Synchrotronstrahlung (7)
- Systematik (7)
- Säugetiere (7)
- T cell receptor (7)
- TRAF2 (7)
- Tissue engineering (7)
- Toxoplasma gondii (7)
- Transcriptome (7)
- Transfektion (7)
- TrkB (7)
- Ubiquitinierung (7)
- Umfrage (7)
- United States (7)
- Unternehmen (7)
- Unternehmensbewertung (7)
- Vagus (7)
- Vaskularisation (7)
- Vegetation (7)
- Venusfliegenfalle (7)
- Verbraucherverhalten (7)
- Verkehrspsychologie (7)
- Verunreinigung (7)
- Vestibularisschwannom (7)
- Wilms tumor (7)
- Wolfram (7)
- Wundinfektion (7)
- X-ray (7)
- Zellwand (7)
- Zoologie (7)
- Zytoskelett (7)
- Zytotoxizität (7)
- acute ischemic stroke (7)
- acute myeloid leukemia (7)
- adolescent (7)
- adsorption (7)
- adult neurogenesis (7)
- algorithm (7)
- altitudinal gradient (7)
- anemia (7)
- animal behavior (7)
- animal behaviour (7)
- antibacterial activity (7)
- antibiotic resistance (7)
- antidepressant (7)
- arabidopsis thaliana (7)
- aspergillosis (7)
- automation (7)
- autonomic nervous system (7)
- basal ganglia (7)
- biomaterials (7)
- bioprinting (7)
- blood flow (7)
- bone mineral density (7)
- bone regeneration (7)
- brain development (7)
- brain-computer interface (7)
- butyrate (7)
- caffeine (7)
- capillary electrophoresis (7)
- carbon dioxide (7)
- carcinoma (7)
- catecholamines (7)
- cell membranes (7)
- cerebellum (7)
- change detection (7)
- chemokine receptor (7)
- click chemistry (7)
- co-culture (7)
- cognition (7)
- cognitive control (7)
- cognitive decline (7)
- comparative genomics (7)
- complexes (7)
- complexity (7)
- cytokinesis (7)
- degeneration (7)
- degradation (7)
- design (7)
- developmental biology (7)
- diagnostics (7)
- diborynes (7)
- diffusion (7)
- drought (7)
- drug (7)
- drug design (7)
- dyes (7)
- endurance (7)
- enzyme (7)
- enzymes (7)
- exciton (7)
- extracellular vesicles (7)
- facial expression (7)
- facial expressions (7)
- feedback (7)
- femtosecond spectroscopy (7)
- fibromyalgia syndrome (7)
- fluorescence imaging (7)
- fluorescent probes (7)
- fungal infection (7)
- gastrointestinal tract (7)
- genomic damage (7)
- glucocorticoid receptor (7)
- guard cell (7)
- heterocycles (7)
- honey bee (7)
- hymenoptera (7)
- hypophosphatasia (7)
- immersion (7)
- immune system (7)
- immunofluorescence (7)
- immunoprecipitation (7)
- infections (7)
- inflammatory bowel disease (7)
- isolation (7)
- kinase (7)
- knockout mice (7)
- kolorektales Karzinom (7)
- localization (7)
- locomotion (7)
- luciferase (7)
- marine sponges (7)
- medulloblastoma (7)
- megakaryocytes (7)
- membrane (7)
- meningitis (7)
- methionine (7)
- minimally invasive (7)
- modeling (7)
- monoclonal antibody (7)
- motility (7)
- motoneuron (7)
- motor learning (7)
- mri (7)
- multicenter (7)
- myelin (7)
- myocarditis (7)
- nanodiamond (7)
- neuroblastoma (7)
- neuromuscular junction (7)
- neurotrophins (7)
- noise (7)
- nucleus (7)
- oxidation (7)
- pH (7)
- pathogenesis (7)
- pediatric (7)
- pemphigus (7)
- personalized medicine (7)
- photoinduced electron transfer (7)
- plasmodium falciparum (7)
- polycaprolactone (7)
- population (7)
- potassium (7)
- pre-speech development (7)
- precision medicine (7)
- prospective (7)
- public health (7)
- pulse shaping (7)
- quantum dynamics (7)
- radioiodine therapy (7)
- random forest (7)
- recognition (7)
- recruitment (7)
- reperfusion (7)
- resilience (7)
- responses (7)
- retina (7)
- risk factor (7)
- rotator cuff (7)
- sRNA (7)
- salt stress (7)
- secondary prevention (7)
- segmentation (7)
- semiconductors (7)
- serotonin transporter (7)
- sex chromosomes (7)
- sex differences (7)
- shear stress (7)
- signaltransduction (7)
- silver (7)
- small RNA (7)
- small fiber neuropathy (7)
- social anxiety (7)
- speech audiometry (7)
- superconductivity (7)
- survey (7)
- systems biology (7)
- target (7)
- taxonomy (7)
- telomeres (7)
- thermodynamics (7)
- thrombo-inflammation (7)
- total hip arthroplasty (7)
- translational research (7)
- translocation (7)
- trial (7)
- two-dimensional materials (7)
- variability (7)
- virus (7)
- visual system (7)
- wearable (7)
- Übergangsmetalloxide (7)
- Übergewicht (7)
- - (6)
- 18F-FDG (6)
- 19. Jahrhundert (6)
- 2 (6)
- ABA (6)
- ACC (6)
- AMPK (6)
- ANP (6)
- ATLAS <Teilchendetektor> (6)
- Abwehrreaktion (6)
- Akustikusneurinom (6)
- Akute Leukämie (6)
- Allergy (6)
- Alpen (6)
- Amino acids (6)
- Amygdala (6)
- Analoga (6)
- Anatolische Sprachen (6)
- Angeborene Immunität (6)
- Angsterkrankungen (6)
- Anionentranslokator (6)
- Antibody (6)
- Antizipation (6)
- Aortenaneurysma (6)
- Aortenklappenstenose (6)
- Arbeitsteilung (6)
- Assoziatives Gedächtnis (6)
- Atriales natriuretisches Hormon (6)
- Aufsichtsrat (6)
- Automation (6)
- B-cell lymphoma (6)
- B7-H1 (6)
- BCI (6)
- BRAF (6)
- BRCA1 (6)
- Beta-Rezeptor (6)
- Bildgebung (6)
- Bildung (6)
- Bilharziose (6)
- Biologische Uhr (6)
- Biology (6)
- Blutstillung (6)
- Borheterocyclen (6)
- Boğazköy (6)
- Bronchialasthma (6)
- C-reactive protein (6)
- CD1d (6)
- CML (6)
- CNTF (6)
- COPD (6)
- CRPS (6)
- Calcineurin (6)
- Campylobacter jejuni (6)
- Carcinogen (6)
- Cataglyphis (6)
- Chemische Bindung (6)
- Chemotaxis (6)
- Chromatographie (6)
- Chromophor (6)
- Chronophin (6)
- Ciliary neurotrophic factor (6)
- Computational Chemistry (6)
- Cycloaddition (6)
- Cyclodextrine (6)
- DFB-Laser (6)
- DNA binding (6)
- DNA-Methylierung (6)
- Datenanalyse (6)
- Dehydroepiandrosteron (6)
- Desfluran (6)
- Domäne <Biochemie> (6)
- Dreidimensionale Rekonstruktion (6)
- Drugs (6)
- Dünnschichtsolarzelle (6)
- EBV (6)
- ECM (6)
- EHEC (6)
- EKP (6)
- Earth observation (6)
- Ecology (6)
- Ehrenamtliche Tätigkeit (6)
- Einkaufszentrum (6)
- Elektroporation (6)
- Enantioselektivität (6)
- Endocytose (6)
- Endodontie (6)
- Endozytose (6)
- Enterobacteriaceae (6)
- Entscheidungsunterstützungssystem (6)
- Entwicklungsländer (6)
- Entwicklungspsychologie (6)
- Fabry (6)
- Fahrerverhalten (6)
- Fanconi Anemia (6)
- Fas-Ligand (6)
- Fatigue (6)
- Finanzmathematik (6)
- Fn14 (6)
- Formicidae (6)
- Fotoionisation (6)
- Fotophysik (6)
- Fourier-Spektroskopie (6)
- Fragmentation (6)
- Frankreich (6)
- Französisch (6)
- Funktion (6)
- Funktionelle NMR-Tomographie (6)
- GC-MS (6)
- GPVI (6)
- GaAs (6)
- Gammaastronomie (6)
- Gender (6)
- Gentoxizität (6)
- Geobotanik (6)
- Gerste (6)
- Geschlechtsbestimmung (6)
- Gesicht (6)
- Glucose (6)
- Glucosetransportproteine (6)
- Gluino Production (6)
- Glykoproteine (6)
- Glykosylierung (6)
- Gold (6)
- Growth (6)
- Grundschulkind (6)
- HAART (6)
- HBMEC (6)
- HGF (6)
- Hadron colliders (6)
- Halbleiteroberfläche (6)
- Hautbiopsie (6)
- HeLa cells (6)
- Heparin (6)
- Hepatitis C (6)
- Hepatozyten-Wachstumsfaktor (6)
- Herzkatheter (6)
- Heterocyclische Verbindungen (6)
- Higgs bosons (6)
- Higgs physics (6)
- Hochtemperatursupraleiter (6)
- Hubbard model (6)
- Humanismus (6)
- Hydrogeologie (6)
- Hypertension (6)
- Hypothalamus (6)
- Hypoxia (6)
- Hörgerät (6)
- Hörverlust (6)
- Hüftgelenkprothese (6)
- ICD-10 (6)
- ITS2 (6)
- Imaging (6)
- Immun-Checkpoint (6)
- Immunaktivierung (6)
- Immunoblot (6)
- Immuntoleranz (6)
- Infrarotspektroskopie (6)
- Integration (6)
- Intensivstation (6)
- Interferon <gamma-> (6)
- Interleukin-4 (6)
- IoT (6)
- Juvenile idiopathische Arthritis (6)
- Kation (6)
- Keratinozyt (6)
- Kiefergelenk (6)
- Kinasen (6)
- Kleinkern (6)
- Knochendichte (6)
- Knochenmark (6)
- Kohlenhydrate (6)
- Komplexität (6)
- Komplexitätstheorie (6)
- Konjugierte Polymere (6)
- Koordinationschemie (6)
- Kostimulation (6)
- Kraniosynostose (6)
- Körperliche Aktivität (6)
- LASP-1 (6)
- LOH (6)
- Ladungstransport (6)
- Large Hadron Collider (6)
- Laserspektroskopie (6)
- Latrophilin (6)
- Legionella (6)
- Leistung (6)
- Leonhard classification (6)
- Leonhard-Klassifikation (6)
- Lipide (6)
- Lymphome (6)
- Lymphozyten (6)
- MASS (6)
- MHC (6)
- Magenchirurgie (6)
- Magnetic Resonance Imaging (6)
- Magnetic resonance imaging (6)
- Magnetowiderstand (6)
- Makroökonomie (6)
- Manisch-depressive Krankheit (6)
- Mechanisms (6)
- Medien (6)
- Melanin (6)
- Melanoma (6)
- Membran (6)
- Memory (6)
- Mensch-Maschine-Schnittstelle (6)
- Metabolism (6)
- Metabolomics (6)
- Metagedächtnis (6)
- Metalloproteinasen (6)
- Methylation (6)
- Mikrobiologie (6)
- Mikroresonator (6)
- Mitochondria (6)
- Molekulardesign (6)
- Monoklonaler bispezifischer Antikörper (6)
- Montessori (6)
- Morbus Crohn (6)
- Multidrug-Resistenz (6)
- Multiple sclerosis (6)
- Mutationsanalyse (6)
- Myatrophische Lateralsklerose (6)
- Mykenische Kultur (6)
- Myocardial infarction (6)
- Myokard (6)
- NLO Computations (6)
- NLRP3 (6)
- NMR spectroscopy (6)
- NRF2 (6)
- Nachhaltigkeitsrecht (6)
- Nachuntersuchung (6)
- Nahrung (6)
- Nanoparticles (6)
- Nasenschleimhaut (6)
- Nationalsozialismus (6)
- Nebennierenkarzinom (6)
- Nebennierenrindeninsuffizienz (6)
- Nebennierentumor (6)
- Nephroblastom (6)
- Neue Medien (6)
- Neugeborene (6)
- Neuroanatomie (6)
- Neurofascin (6)
- Neurologie (6)
- Neuromonitoring (6)
- Nichtlineare Optimierung (6)
- Nickel (6)
- Nickelkomplexe (6)
- Non-coding RNA (6)
- Notfall (6)
- Nucleinsäuren (6)
- Nuklearfaktor Kappa B (6)
- OLED (6)
- Olfaction (6)
- Oncology (6)
- Oozyte (6)
- Opioide (6)
- Optik (6)
- Optogenetics (6)
- PCI (6)
- Paracetamol (6)
- Pathologie (6)
- Peptidsynthese (6)
- Perowskit (6)
- Pflanzengeographie (6)
- Phonologische Bewusstheit (6)
- Phosphane (6)
- Photophysik (6)
- Physikalische Chemie (6)
- Phänotyp (6)
- Plastizität (6)
- Platelet (6)
- Platinkomplexe (6)
- Plattenosteosynthese (6)
- Politik (6)
- Polymerisation (6)
- Polymerkomplexe (6)
- Porin (6)
- Probiotikum (6)
- Proteasom (6)
- Proteom (6)
- Prothetik (6)
- Pulver (6)
- QM/MM (6)
- Quanteninformation (6)
- RNA polymerase II (6)
- RNAi (6)
- RT-PCR (6)
- Rac1 (6)
- Raf (6)
- Rashba-Effekt (6)
- Reaktive Sauerstoffspezies (6)
- Rechnernetz (6)
- Rechtsprechung (6)
- Regulatory T cells (6)
- Rektumkarzinom (6)
- Religionsunterricht (6)
- Renin-Angiotensin-System (6)
- Resektion (6)
- Resilienz (6)
- Retina (6)
- Rheologie (6)
- RhoA (6)
- Rhodopsin (6)
- Ribosom (6)
- Risiko (6)
- Routing (6)
- SDN (6)
- SSTR (6)
- Salmonella enterica (6)
- Schrei (6)
- Selbsteinschätzung (6)
- Selen (6)
- Self-assembly (6)
- Semiconductor (6)
- Sensitivität (6)
- Sensor (6)
- Signalkette (6)
- Siliciumkomplexe (6)
- Siloxane (6)
- Skalierung (6)
- Smad (6)
- Small nuclear RNP (6)
- Software (6)
- Sol-Gel (6)
- Solarzelle (6)
- Soziologie (6)
- Sprachentwicklungsstörung (6)
- Sprachtest (6)
- Stickstoffoxidsynthase (6)
- Strahlensensibilität (6)
- Streptococcus pneumoniae (6)
- Streptomyces (6)
- Stroma (6)
- Supramolecular Chemistry (6)
- T-lymphocytes (6)
- TAVI (6)
- TGF-beta (6)
- TNF-alpha (6)
- TNFR2 (6)
- Targeted drug delivery (6)
- Temperatur (6)
- Therapeutic Drug Monitoring (6)
- Therapieerfolg (6)
- Thermodynamik (6)
- Thermoregulation (6)
- Tinnitus (6)
- Toleranz (6)
- Tomate (6)
- Top physics (6)
- Transgene Tiere (6)
- Transiente Absorption (6)
- Transkriptom (6)
- Transporter (6)
- Transposon (6)
- Treatment (6)
- Troponin (6)
- Tuberkulose (6)
- Tumortherapie (6)
- UV-VIS-Spektroskopie (6)
- Ultrafast spectroscopy (6)
- Umweltschutz (6)
- Ungleichheit (6)
- Universitätsbibliothek Würzburg (6)
- VSG (6)
- Vaccination (6)
- Valenz <Linguistik> (6)
- Vergleichende politische Wissenschaft (6)
- Verteiltes System (6)
- Virtual Reality (6)
- Virtualisierung (6)
- Virus (6)
- Viskosität (6)
- Wechselwirkung (6)
- Wissen (6)
- Wortschatz (6)
- Wärmeleitfähigkeit (6)
- XPS (6)
- Xenopus laevis (6)
- Zelllinie (6)
- Zellteilung (6)
- Zirkulardichroismus (6)
- acid sphingomyelinase (6)
- actinomycetes (6)
- adenosine (6)
- alignment (6)
- alkaloids (6)
- alternative splicing (6)
- anatomy (6)
- anorexia nervosa (6)
- anthocyanins (6)
- antidepressants (6)
- antimicrobial peptides (6)
- antioxidants (6)
- arthroscopy (6)
- aspergillus fumigatus (6)
- astrocytoma (6)
- auditory (6)
- autoantibody (6)
- autoimmune disease (6)
- bacterial pathogens (6)
- bee (6)
- behavioral conditioning (6)
- biophysics (6)
- biopsy (6)
- bioreactor (6)
- body weight (6)
- boronate esters (6)
- brain tumor (6)
- cancer immunotherapy (6)
- cancer metabolism (6)
- cancer stem cells (6)
- cardiomyocytes (6)
- cardiovascular diseases (6)
- cell (6)
- cell proliferation (6)
- cement (6)
- childhood (6)
- chlamydia (6)
- chondrocytes (6)
- circadian rhythm (6)
- circular dichroism (6)
- climate (6)
- clinical study (6)
- colon cancer (6)
- comet assay (6)
- comorbidity (6)
- competition (6)
- cosmology (6)
- cyclodextrin (6)
- cytokinins (6)
- damage (6)
- deadwood (6)
- democracy (6)
- density functional theory (6)
- dental education (6)
- detoxification (6)
- disability (6)
- down regulation (6)
- drosophila melanogaster (6)
- drug discovery (6)
- drugs (6)
- eHealth (6)
- eating disorders (6)
- efficiency (6)
- ejection fraction (6)
- encephalitis (6)
- endovascular (6)
- energy metabolism (6)
- engagement (6)
- estrogens (6)
- ethanol (6)
- experience (6)
- exposure (6)
- eye movements (6)
- eye tracking (6)
- eyes (6)
- factor XII (6)
- fear generalization (6)
- fibromyalgia (6)
- fish (6)
- fluorescence resonance energy transfer (6)
- fluorine (6)
- follicular lymphoma (6)
- functional magnetic resonance imaging (6)
- gas phase (6)
- geomorphology (6)
- germinal center (6)
- glaucoma surgery (6)
- global warming (6)
- glucocorticoids (6)
- glutamate (6)
- glycoprotein VI (6)
- grazing (6)
- guard cells (6)
- guideline adherence (6)
- heterochromatin (6)
- homeostasis (6)
- homogeneous catalysis (6)
- honeybees (6)
- host-pathogen interaction (6)
- hydroboration (6)
- hyperexpression techniques (6)
- ideomotor theory (6)
- immune cells (6)
- immunity (6)
- impulsivity (6)
- in vitro selection (6)
- incisional hernia (6)
- infarction (6)
- infectious diseases (6)
- influenza (6)
- information (6)
- infrared spectroscopy (6)
- inhibitors (6)
- intraocular pressure (6)
- kidneys (6)
- language (6)
- leishmaniasis (6)
- lesions (6)
- lipids (6)
- localization microscopy (6)
- lung fibrosis (6)
- lysosome (6)
- magnetic properties and materials (6)
- magnetic resonance (6)
- mechanical thrombectomy (6)
- medaka (6)
- medical education (6)
- meningococcal disease (6)
- metabolic syndrome (6)
- miR-21 (6)
- microbiota (6)
- microdialysis (6)
- modelling (6)
- models (6)
- molecular neuroscience (6)
- motor control (6)
- movement disorders (6)
- murine (6)
- muscarinic receptors (6)
- muscle (6)
- mushroom bodies (6)
- myeloma (6)
- naphthylisoquinoline alkaloids (6)
- natural disturbance (6)
- natural products (6)
- nephrotoxicity (6)
- neurobiology (6)
- neurodevelopment (6)
- neuronal differentiation (6)
- nuclear medicine (6)
- octopamine (6)
- oilseed rape (6)
- organization (6)
- osteogenic differentiation (6)
- osteoinduction (6)
- osteosynthesis (6)
- outcomes (6)
- pathways (6)
- periprosthetic infection (6)
- persistence (6)
- phagocytosis (6)
- phenology (6)
- photoluminescence (6)
- phylogenetic trees (6)
- physiology (6)
- plasma membrane (6)
- polarization (6)
- polymerase chain reaction (6)
- polyneuropathy (6)
- polyphenols (6)
- predictors (6)
- protease inhibitors (6)
- protein binding (6)
- protein kinase (6)
- quantum optics (6)
- radical (6)
- radiosensitivity (6)
- repair (6)
- response inhibition (6)
- retinal pigment epithelium (6)
- reward (6)
- risk stratification (6)
- ruthenium (6)
- scale (6)
- school (6)
- semiconductor laser (6)
- semiconductor lasers (6)
- sensitivity (6)
- sensor (6)
- sequence (6)
- sequence alignment (6)
- siRNA (6)
- signaling pathway (6)
- signalling (6)
- skeletal muscle (6)
- skin (6)
- sleeping sickness (6)
- small interfering RNAs (6)
- social attention (6)
- sol-gel (6)
- solar cells (6)
- solubility (6)
- somatic mutations (6)
- spacer (6)
- spectral karyotyping (6)
- sponges (6)
- stability (6)
- states (6)
- stomata (6)
- structural biology (6)
- supersymmetry (6)
- surface (6)
- sustainability (6)
- symptoms (6)
- system (6)
- thermoregulation (6)
- thrombin (6)
- thymoma (6)
- thyroid cancer (6)
- time-resolved spectroscopy (6)
- tissue (6)
- titanium (6)
- tomography (6)
- total synthesis (6)
- training (6)
- transfection (6)
- transition metal (6)
- tumor immunology (6)
- tumor necrosis factor (6)
- uveal melanoma (6)
- valence (6)
- vascularization (6)
- viral infection (6)
- volatile anesthetics (6)
- weight loss (6)
- wild bees (6)
- Überlebenszeit (6)
- 3D cell culture (5)
- 3D-Pulverdruck (5)
- 5-HTTLPR (5)
- ABC-Transporter (5)
- ACE-Hemmer (5)
- ACTH (5)
- AFM (5)
- AI (5)
- AMD (5)
- ATP (5)
- Absorptionsspektroskopie (5)
- Abstimmbarer Laser (5)
- Actin-bindende Proteine (5)
- Adenokarzinom (5)
- Adoleszenz (5)
- Adult (5)
- Aggression (5)
- Agonist (5)
- Aktivierung <Chemie> (5)
- Akustikustumor (5)
- Akzeptanz (5)
- Alkine (5)
- Alkoholismus (5)
- Altersversorgung (5)
- Alzheimer (5)
- Angstsensitivität (5)
- Antigenpräsentation (5)
- Antimikrobieller Wirkstoff (5)
- Antioxidantien (5)
- Aquaporin (5)
- Arbeitsmarkt (5)
- Archaeology (5)
- Arthrodese (5)
- Assoziationsstudie (5)
- Augenheilkunde (5)
- Aurora-A (5)
- Ausstellungskatalog (5)
- Autoantigen (5)
- Autoimmunerkrankung (5)
- Automatisierung (5)
- Axon (5)
- B cell (5)
- B-MYB (5)
- B-cells (5)
- Bcl-2 (5)
- Begabung (5)
- Belastung (5)
- Berechnung (5)
- Beta-1-Rezeptor (5)
- Betriebliche Altersversorgung (5)
- Bewusstsein (5)
- Biofabrication (5)
- Biogenese (5)
- Biologischer Abbau (5)
- Biopsie (5)
- Blei (5)
- Boden (5)
- Bone regeneration (5)
- Borane (5)
- Borate (5)
- Breaking (5)
- Bronzezeit (5)
- Bruschit (5)
- Bruxismus (5)
- C. elegans (5)
- CD-Spektroskopie (5)
- CD8 (5)
- CEACAM1 (5)
- CIDP (5)
- CSF (5)
- CVID (5)
- CYR61 (5)
- Cadmiumselenid (5)
- Camponotus (5)
- Caspasen (5)
- Ceramide (5)
- Channelrhodopsin (5)
- Chemotherapy (5)
- Chiralität (5)
- Cholesterin (5)
- Chronisch thromboembolische pulmonale Hypertonie (5)
- Chronischer Schmerz (5)
- Churriter (5)
- Climate change (5)
- Cochlea (5)
- Cognitive control (5)
- Coherent Multidimensional Spectroscopy (5)
- Colitis ulcerosa (5)
- Computer Center (5)
- Crohn-Krankheit (5)
- CubeSat (5)
- Cuneiform text (5)
- Cystein (5)
- Cytokines (5)
- DNA replication (5)
- DNA-Reparatur (5)
- Dark Matter (5)
- Degeneration (5)
- Deletion (5)
- Demökologie (5)
- Development (5)
- Diabetes mellitus Typ 1 (5)
- Diels-Alder reactions (5)
- Differentialgleichung (5)
- Dimension 3 (5)
- Distale Radiusfraktur (5)
- Drahtloses Sensorsystem (5)
- Dystonie (5)
- Earth Observation (5)
- Electron microscopy (5)
- Electrospinning (5)
- Elektronendichte (5)
- Elektronengas (5)
- Embryonale Stammzelle (5)
- Emotionen (5)
- Encephalitis (5)
- Energietransfer (5)
- Energy (5)
- Entscheidung (5)
- Entscheidungsunterstützung (5)
- Entwicklungsbiologie (5)
- Enzyme replacement therapy (5)
- Epigenetic (5)
- Erythropoietin (5)
- Essverhalten (5)
- European Union (5)
- Expositionstherapie (5)
- Extinktion (5)
- FACS (5)
- FGF (5)
- FGFR (5)
- Fahrerassistenzsystem (5)
- Fermionensystem (5)
- Festkörpertheorie (5)
- Film (5)
- Fließregulierung (5)
- Fluoreszenzkorrelationsspektroskopie (5)
- Foamyviren (5)
- Fragmentierung (5)
- Frühdiagnostik (5)
- Funde (5)
- Furchtgeneralisierung (5)
- Furchtkonditionierung (5)
- G-protein (5)
- GDNF (5)
- GFAP (5)
- GWAS (5)
- Gastrointestinaltrakt (5)
- Geburtshilfe (5)
- Gefäßprothese (5)
- Gemeinde (5)
- Gen notch (5)
- Gene (5)
- Gene-expression (5)
- Gentransfer (5)
- Gephyrin (5)
- German as a foreign language (5)
- Gewebedoppler (5)
- Gewebekultur (5)
- Glas (5)
- Glutamattransporter (5)
- Glycinrezeptor (5)
- Governance (5)
- Graph (5)
- Graphenzeichnen (5)
- GvHD (5)
- HLA-G (5)
- HMG-Proteine (5)
- HRV (5)
- HUWE1 (5)
- Halbleiterschicht (5)
- Halbsandwich-Verbindungen (5)
- Hals-Nasen-Ohren-Tumor (5)
- Handelsforschung (5)
- Handlung (5)
- Heilpflanzen (5)
- Hepatitis B (5)
- Herzschrittmacher (5)
- Hittites (5)
- Hochauflösendes Verfahren (5)
- Homogene Katalyse (5)
- Hormone (5)
- Humorale Immunität (5)
- Hydroxylapatit (5)
- Hämatopoese (5)
- Hörscreening (5)
- ICD (5)
- IL-2 (5)
- IMRT (5)
- Imatinib (5)
- Immunität <Medizin> (5)
- Immunoassay (5)
- Immunobiologie (5)
- Impurity Profiling (5)
- In-vitro-Kultur (5)
- In-vivo (5)
- InSAR (5)
- Influenza (5)
- Insulin-like Growth Factor I (5)
- Interleukin 2 (5)
- Internationalisierung (5)
- Invasive Aspergillose (5)
- Jasmonsäure (5)
- Judit <Buch> (5)
- Kardiovaskuläres System (5)
- Karl Leonhard (5)
- Kartierung (5)
- Keimzentrum (5)
- Kernproteine (5)
- Kerntransport (5)
- Kidney (5)
- Kinase (5)
- Kinder und Jugendliche (5)
- Kinder- und Jugendpsychiatrie (5)
- Kinematik (5)
- Kirche (5)
- Klassische Konditionierung (5)
- Klinisches Experiment (5)
- Knorpelzelle (5)
- Kombinationstherapie (5)
- Kombinatorische Synthese (5)
- Komorbidität (5)
- Komorbiditäten (5)
- Komplement (5)
- Komödie (5)
- Kondensierte Materie (5)
- Konsumentenverhalten (5)
- Kontrollierte Wirkstofffreisetzung (5)
- Kontrollierte klinische Studie (5)
- Kosmologie (5)
- Krankheit (5)
- Krebsforschung (5)
- Kunsterziehung (5)
- Käfer (5)
- Körperliche Leistungsfähigkeit (5)
- LL-37 (5)
- Laktat (5)
- Latenz (5)
- Lautheit (5)
- Learner autonomy (5)
- Lebensmittel (5)
- Leberzellkrebs (5)
- Leberzirrhose (5)
- Lehrerfortbildung (5)
- Lehrmittel (5)
- Leishmania major (5)
- Leistungsdiagnostik (5)
- Lesen (5)
- Lewis-Base (5)
- Linienbandkeramik (5)
- Listeria (5)
- Lung (5)
- Lymphknoten (5)
- MAGIC-Teleskop (5)
- Macaranga (5)
- Magenkrebs (5)
- Magnetischer Halbleiter (5)
- Malaria tropica (5)
- Management (5)
- Manganverbindungen (5)
- Mangelernährung (5)
- Mathematische Modellierung (5)
- Medizingeschichte (5)
- Medulloblastoma (5)
- Meerschweinchen (5)
- Membrantransport (5)
- Messung (5)
- Metabolom (5)
- Metabolomik (5)
- Metagenom (5)
- Metallocenophane (5)
- Metallorganische Polymere (5)
- Metallorganische Verbindungen (5)
- Metallorganisches Netzwerk (5)
- Microtubules (5)
- Migräne (5)
- Mikrokern (5)
- Mikroorganismus (5)
- Mikrotubulus (5)
- Minimal-invasive Chirurgie (5)
- Minoische Kultur (5)
- Mitomycin C (5)
- Monetary Policy (5)
- Monoschicht (5)
- Morphology (5)
- Mouse (5)
- Mozart (5)
- Multiple Sclerosis (5)
- Multiproteinkomplex (5)
- Muskeldystrophie (5)
- Muskelzelle (5)
- Mutationen (5)
- Mutualismus (5)
- Myelom (5)
- Mädchen (5)
- NASH (5)
- NEXAFS (5)
- NF-AT (5)
- NF-KAPPA-B (5)
- NF-kappaB (5)
- NFκB (5)
- NGA (5)
- NLO computations (5)
- NPY (5)
- Nachkriegszeit (5)
- Nahfeldoptik (5)
- Nahinfrarotspektroskopie (5)
- Namibia <Nordwest> (5)
- Nanometerbereich (5)
- Nanooptik (5)
- Nanoröhre (5)
- Narbenhernie (5)
- Narkose (5)
- Natriumkanal (5)
- Natural Products (5)
- Naturschutz (5)
- Nebennierenrinde (5)
- Nebenschilddrüse (5)
- Neisseria (5)
- Nekrose (5)
- Nervenfaser (5)
- Neurogenetik (5)
- Neuronales Netz (5)
- Neuropathy (5)
- Neuropeptide (5)
- Neurophysiologie (5)
- Neuroprotektion (5)
- Neurowissenschaften (5)
- Nichtlineare Spektroskopie (5)
- Niederdimensionaler Halbleiter (5)
- Niederschlag (5)
- Notenbank (5)
- OCD (5)
- OCT (5)
- Oberflächenfunktionalisierung (5)
- Oberflächenverstärkter Raman-Effekt (5)
- Occludin (5)
- Oligomerisation (5)
- Opiatrezeptor (5)
- Optimization (5)
- Optische Fernerkundung (5)
- Orientierung (5)
- Ovarialkarzinom (5)
- P4 (5)
- PALM (5)
- PDE (5)
- PDXP (5)
- PMMA (5)
- Pandemie (5)
- Pankreas (5)
- Parallele Bildgebung (5)
- Patientenverfügung (5)
- Patientenzufriedenheit (5)
- Pentakoordination (5)
- Periphere Stammzellentransplantation (5)
- Permeation (5)
- Perovskite (5)
- Perylenbisdicarboximide <Perylen-3,4:9,10-bis(dicarboximide)> (5)
- Perylendianhydrid (5)
- Pflanzenfressende Insekten (5)
- Pharmazie (5)
- Phasenvariation (5)
- Philosophie (5)
- Phosphatase (5)
- Phosphatasen (5)
- Phosphine (5)
- Photochemische Reaktion (5)
- Photochemistry (5)
- Photoemission (5)
- Phytoprostane (5)
- Pilze (5)
- Piperidinderivate (5)
- PolSAR (5)
- Polymer (5)
- Polyphenole (5)
- Polysomnographie (5)
- Portugiesisch (5)
- Positronen-Emissions-Tomographie (5)
- Posttranskriptionelle Regulation (5)
- Prednisolon (5)
- PrfA (5)
- Primaten (5)
- Projektarbeit (5)
- Propaganda (5)
- Protease (5)
- Protein-Protein-Wechselwirkung (5)
- Proteinkinase A (5)
- Proteinkinasen (5)
- Prothese (5)
- Prädiktor (5)
- Prädiktoren (5)
- Prävalenz (5)
- Punktmutation (5)
- Pyrolyse (5)
- Pädagogische Psychologie (5)
- Qualitative Inhaltsanalyse (5)
- Qualitätsmanagement (5)
- Quantenkontrolle (5)
- Quantenspinsystem (5)
- Quantitative anatomy (5)
- RADS (5)
- RFID (5)
- RS-Virus (5)
- RS1 (5)
- RYGB (5)
- Radioiodtherapie (5)
- Randschluss (5)
- Rapid Prototyping (5)
- RapidEye (5)
- Rauchen (5)
- Raumordnung (5)
- Reaktionskinetik (5)
- Reaktionsmechanismus (5)
- Regression (5)
- Regulatorische T-Zellen (5)
- Reinheitsanalytik (5)
- Reproduktionsmedizin (5)
- Reverse Transkriptase-Polymerase-Kettenreaktion (5)
- Ribavirin (5)
- Risikoanalyse (5)
- Risk (5)
- Roboter (5)
- Rutheniumkomplexe (5)
- Röntgenbeugung (5)
- Röntgenstrahlung (5)
- SLAC1 (5)
- STEC (5)
- Sagittalnahtsynostose (5)
- Salzstress (5)
- Savanne (5)
- Scaffold (5)
- Schlafkrankheit (5)
- Schreiben (5)
- Schulbuch (5)
- Schwamm (5)
- Sekundarstufe (5)
- Selbst (5)
- Selektivität (5)
- Semitistik (5)
- Senile Makuladegeneration (5)
- Septuaginta (5)
- Sequenzanalyse (5)
- Signal transduction (5)
- Silylen (5)
- Skelettmuskel (5)
- Skin (5)
- Software Defined Networking (5)
- Software Engineering (5)
- Sonderpädagogik / Wörterbuch (5)
- Sonderpädagogik / Zeitschrift (5)
- Sonographie (5)
- Spaltöffnung (5)
- Spectroscopy (5)
- Speichel (5)
- Spermatogenese (5)
- Spezifität (5)
- Spin flip (5)
- Sport (5)
- Spred-Proteine (5)
- Stability (5)
- Stadtentwicklung (5)
- Standardmodell <Elementarteilchenphysik> (5)
- Standortplanung (5)
- Standortpolitik (5)
- Staphylococcus epidermidis (5)
- Startle (5)
- Stem cells (5)
- Stereochemie (5)
- Sterilität (5)
- Stimulation (5)
- Strahlungstransport (5)
- Strain (5)
- Structural Biology (5)
- Struktur-Aktivitäts-Beziehung (5)
- Studium (5)
- Supraleiter (5)
- Symmetrie (5)
- Synapsin (5)
- Synaptonemalkomplex (5)
- Synthesediamant (5)
- Systemtheorie (5)
- T-cell (5)
- TKI (5)
- TLR4 (5)
- TMJ (5)
- TNF-α (5)
- TP53 (5)
- Taxonomie (5)
- TerraSAR-X (5)
- Textlinguistik (5)
- Theoretical Chemistry (5)
- Theoretische Informatik (5)
- Theoretische Physik (5)
- Thrombozytenaggregation (5)
- Titandioxid (5)
- Top quark (5)
- Totalendoprothese (5)
- Toxin (5)
- Tragödie (5)
- Transformation (5)
- Transportprozess (5)
- Triarylamine (5)
- Tumorsuppressorgen (5)
- Ugarit (5)
- Ultraschallkardiographie (5)
- Umwelt (5)
- Unterkiefer (5)
- Urämie (5)
- VE-Cadherin (5)
- Vaccine (5)
- Vaccinia virus (5)
- Validation (5)
- Vaskularisierung (5)
- Venlafaxin (5)
- Ventilation (5)
- Verarbeitungsflüssigkeit (5)
- Verbundfestigkeit (5)
- Visualization (5)
- Visuelle Wahrnehmung (5)
- Wachstumsfaktor (5)
- Wasser (5)
- Wasserstoffbrückenbindung (5)
- Wettbewerb (5)
- Wirtschaft (5)
- Wortbildung (5)
- Würzburger Hörfeld (5)
- XMCD (5)
- XRD (5)
- Yersinia enterocolitica (5)
- Zea mays (5)
- Zebrafisch (5)
- Zebrafish (5)
- Zink (5)
- Zucker (5)
- accuracy (5)
- acoustic neuroma (5)
- acute heart failure (5)
- adalimumab (5)
- adenocarcinoma (5)
- adipocytes (5)
- adrenal (5)
- adrenal insufficiency (5)
- akute Herzinsuffizienz (5)
- alcohol (5)
- algorithms (5)
- allosteric modulation (5)
- amino acid (5)
- amplification (5)
- angiography (5)
- ankle (5)
- annotation (5)
- antibiotic (5)
- anticipation (5)
- anticoagulation (5)
- antigenic variation (5)
- antimicrobial stewardship (5)
- antimicrobials (5)
- aorta (5)
- arousal (5)
- arrhythmia (5)
- arthritis (5)
- augmented reality (5)
- autism (5)
- back pain (5)
- balance (5)
- bioink (5)
- bioisosterism (5)
- biokinetics (5)
- biological locomotion (5)
- bismuth (5)
- blood plasma (5)
- blood-brain-barrier (5)
- bond activation (5)
- brain computer interface (5)
- bronchopulmonary dysplasia (5)
- burden (5)
- caloric restriction (5)
- candidate gene (5)
- carcinomas (5)
- cardiac (5)
- cardioprotection (5)
- cardiovascular (5)
- cardiovascular events (5)
- cardiovascular risk factors (5)
- cartilage regeneration (5)
- cell cultures (5)
- cell cycle and cell division (5)
- cell differentiation (5)
- ceramides (5)
- cerebral ischemia (5)
- chemical communication (5)
- chemical ecology (5)
- chemokine (5)
- child (5)
- chirality (5)
- ciliary neurotrophic factor (5)
- cisplatin (5)
- clinical trials (5)
- cloning (5)
- collagens (5)
- complement (5)
- condensed matter physics (5)
- congestive heart failure (5)
- contrast agent (5)
- coronavirus (5)
- correction (5)
- correlation (5)
- costimulation (5)
- creatine kinase (5)
- critical illness (5)
- cross-coupling (5)
- demyelination (5)
- dendritische Zelle (5)
- dentate gyrus (5)
- dexamethasone (5)
- diagnostic markers (5)
- diborene (5)
- discourse analysis (5)
- docking (5)
- driving simulation (5)
- drug repurposing (5)
- dyes/pigments (5)
- ecological momentary assessment (5)
- elderly (5)
- electrochemistry (5)
- electrospinning (5)
- embryo (5)
- emission (5)
- empathy (5)
- encapsulation (5)
- end-stage renal disease (5)
- endoscopy (5)
- endothelial dysfunction (5)
- endothelial progenitor cells (5)
- endurance training (5)
- environment (5)
- enzyme-linked immunoassays (5)
- epithelial-mesenchymal transition (5)
- erythropoietin (5)
- estrogen (5)
- excitons (5)
- experimental design (5)
- eye-tracking (5)
- fatty acids (5)
- fibroblasts (5)
- flagella (5)
- food security (5)
- food-cues (5)
- forensic neuropathology (5)
- fusion (5)
- gait (5)
- galactomannan (5)
- gametogenesis (5)
- gender differences (5)
- gene targeting (5)
- gene-expression (5)
- generation (5)
- genotype (5)
- giant cell arteritis (5)
- glycolysis (5)
- gp130 (5)
- graph drawing (5)
- hearing loss (5)
- heart rate variability (5)
- heat transfer (5)
- hematopoietic stem cells (5)
- history (5)
- hospitalization (5)
- human-computer interaction (5)
- hyperekplexia (5)
- hypertrophy (5)
- immunization (5)
- implementation (5)
- in situ hybridization (5)
- in vitro model (5)
- inflammasome (5)
- inflammatory pain (5)
- innovation (5)
- insulin resistance (5)
- integration (5)
- integrin (5)
- intestinal epithelial barrier (5)
- intestine (5)
- ion channel (5)
- iron oxide nanoparticles (5)
- irradiation (5)
- jasmonates (5)
- keratinocytes (5)
- kinematics (5)
- knee arthroplasty (5)
- lactate (5)
- land cover (5)
- language acquisition (5)
- larvae (5)
- late enhancement (5)
- lipid rafts (5)
- liquid crystals (5)
- long-term outcome (5)
- longitudinal study (5)
- loss of heterozygosity (5)
- loudness (5)
- magnesium phosphate cement (5)
- magnetism (5)
- masked priming (5)
- mast cells (5)
- matrix metalloproteinases (5)
- medical rehabilitation (5)
- megakaryocyte (5)
- mental disorders (5)
- mesenchymal stem cell (5)
- metabarcoding (5)
- microglomeruli (5)
- microsatellite instability (5)
- middle cerebral artery occlusion (5)
- migraine (5)
- migrants (5)
- mineralization (5)
- minimal invasiv (5)
- mobility (5)
- molecular medicine (5)
- morbidity (5)
- motoneurons (5)
- movement ecology (5)
- music (5)
- mycotoxin (5)
- nano (5)
- nanostructures (5)
- natural killer cells (5)
- nature conservation (5)
- neisseria meningitidis (5)
- nephroblastoma (5)
- network (5)
- neuroanatomy (5)
- neuroethology (5)
- neuromelanin (5)
- neuronal plasticity (5)
- neuropeptides (5)
- neuropsychiatric disorders (5)
- neurotrophic factor (5)
- neutrophil (5)
- newborn hearing screening (5)
- nickel (5)
- nitric oxide synthase (5)
- norepinephrine (5)
- nucleolus (5)
- nutrients (5)
- object detection (5)
- oncogenes (5)
- oncolysis (5)
- opioid receptors (5)
- organic semiconductor (5)
- organic synthesis (5)
- organische Halbleiter (5)
- osteoblasts (5)
- osteogenesis (5)
- paraganglioma (5)
- parasitic diseases (5)
- parathyroid hormone (5)
- patch-clamp (5)
- pathogenicity (5)
- peptide (5)
- perception and action (5)
- pharmacokinetic (5)
- phase variation (5)
- phenotypic plasticity (5)
- pheochromocytoma (5)
- photophysics (5)
- phylogenetic analysis (5)
- plant-insect interactions (5)
- plants (5)
- plasma cells (5)
- polyomavirus (5)
- population pharmacokinetics (5)
- porin (5)
- power (5)
- preclinical research (5)
- preterm (5)
- prognostic marker (5)
- promoter (5)
- prostate-specific membrane antigen (5)
- protein domains (5)
- protein expression (5)
- psychiatry (5)
- psychological distress (5)
- pulmonary embolism (5)
- pyrolysis (5)
- quality (5)
- qubit (5)
- radial (5)
- reactive intermediates (5)
- receptor tyrosine kinase (5)
- recombinant proteins (5)
- refractory (5)
- regeneration (5)
- regression analysis (5)
- renal cell carcinoma (5)
- renal function (5)
- replacement (5)
- resin (5)
- resolution (5)
- resveratrol (5)
- retinoic acid (5)
- retrospective (5)
- revision (5)
- ring-opening polymerization (5)
- rotator cuff tear (5)
- saliva (5)
- sarcopenia (5)
- seasonality (5)
- self (5)
- self-organization (5)
- sevoflurane (5)
- sexual selection (5)
- shock (5)
- single-crystal X-ray study (5)
- skin punch biopsy (5)
- soil (5)
- somatostatin receptor (5)
- soziale Insekten (5)
- soziale Kompetenz (5)
- specificity (5)
- spider phobia (5)
- spiders (5)
- spin (5)
- spinal cord (5)
- splicing (5)
- startle disease (5)
- stem-cell transplantation (5)
- strain (5)
- stromal cells (5)
- structural elucidation (5)
- structure-activity relationships (5)
- subarachnoid hemorrhage (5)
- subtypes (5)
- sucrose (5)
- sudden cardiac death (5)
- super-resolution (5)
- surfactants (5)
- sympathetic nervous system (5)
- synaptic proteins (5)
- synaptic vesicles (5)
- synchrotron radiation (5)
- systematic literature review (5)
- teaching (5)
- teeth (5)
- telemedicine (5)
- testosterone (5)
- text comprehension (5)
- thrombolysis (5)
- tight junction (5)
- transcranial direct current stimulation (5)
- transformation (5)
- transgenic mice (5)
- transporter (5)
- transverse momentum (5)
- tremor (5)
- tsetse fly (5)
- tuberculosis (5)
- tumour (5)
- ubiquitination (5)
- uremic toxins (5)
- urine (5)
- vancomycin (5)
- variants (5)
- vasculitis (5)
- ventilation (5)
- violence (5)
- virtual screening (5)
- virulence factors (5)
- visualization (5)
- voluntary service (5)
- well-being (5)
- winter wheat (5)
- wissenschaftlicher Nachwuchs (5)
- women (5)
- xx (5)
- zwitterionic (5)
- Ägäische Kultur (5)
- Ökonometrie (5)
- Überlebensrate (5)
- γ-H2AX (5)
- --- (4)
- 3D Printing (4)
- 3D reconstruction (4)
- 5-Fluorouracil (4)
- ACL (4)
- AGN (4)
- ANCA (4)
- APOBEC3G (4)
- ASSR (4)
- AVHRR (4)
- Ablösung (4)
- Abschlussprüfer (4)
- Abwehr (4)
- Accounting (4)
- Acyrthosiphon pisum (4)
- AdS-CFT Correspondence (4)
- AdS/CFT (4)
- AdS/CFT correspondence (4)
- Addukt (4)
- Adenoviren (4)
- Adenylate cyclase (4)
- Adjuvans (4)
- Adrenocortical Carcinoma (4)
- Adsorbat (4)
- Aerogel (4)
- Ag(111) (4)
- Agoraphobie (4)
- Agrobacterium tumefaciens (4)
- Akromioklavikulargelenk (4)
- Aktionsforschung (4)
- Aktive Zone (4)
- Alkalische Phosphatase (4)
- Alkoholabhängigkeit (4)
- Alternative Medizin (4)
- Alterung (4)
- Altes Testament (4)
- Aluminiumarsenid (4)
- Alveoläre Echinokokkose (4)
- Alzheimers disease (4)
- Ameise (4)
- Amplifikation (4)
- Analgesie (4)
- Analysis (4)
- Anandamid (4)
- Anaphylaxis (4)
- Ancistrocladus (4)
- Aneuploidie (4)
- Aneurysma (4)
- Anfangsunterricht (4)
- Angewandte Psychologie (4)
- Angiogenesis (4)
- Animal model (4)
- Anionenkanal (4)
- Annotation (4)
- Antarctica (4)
- Antennallobus (4)
- Anthropogene Klimaänderung (4)
- Anthropogener Einfluss (4)
- Antiangiogenese (4)
- Antidepressiva (4)
- Antigen CD4 (4)
- Antigen CD44 (4)
- Antigen CD95 (4)
- Antike (4)
- Antimykotikum (4)
- Antioxidans (4)
- Ants (4)
- Anura (4)
- Appendizitis (4)
- Approximationsalgorithmus (4)
- Aroma (4)
- Assoziation (4)
- Astrozytom (4)
- Atemwegsinfektion (4)
- Atlas detector (4)
- Audit Quality (4)
- Augmented Reality (4)
- Autonomie (4)
- Autophagy (4)
- Avidität (4)
- Aziridine (4)
- B chromosomes (4)
- B lymphocytes (4)
- B-Lymphozyten (4)
- B-lymphocytes (4)
- BCG (4)
- BERAphon® (4)
- BMD (4)
- BRET (4)
- Bacillus subtilis (4)
- Bank (4)
- Barth syndrome (4)
- Basaliom (4)
- Bauchfellentzündung (4)
- Begrenzte Staatlichkeit (4)
- Behavior (4)
- Beschaffung (4)
- Bestäubung (4)
- Betriebswirtschaftslehre (4)
- Bevacizumab (4)
- Bewegungssteuerung (4)
- Bienen <Familie> (4)
- Bilanzpolitik (4)
- Bildanalyse (4)
- Bilderzeugung (4)
- Biofilmbildung (4)
- Biophysik (4)
- Bioreaktor (4)
- Bipolar disorder (4)
- Biradikale (4)
- Bismut (4)
- Bisphosphonate (4)
- Blasenkrebs (4)
- Blattkäfer (4)
- Blutgefäß (4)
- Blutspiegel (4)
- Bodenerosion (4)
- Borneo (4)
- Borrelia (4)
- Bortezomib (4)
- Borylation (4)
- Borylen (4)
- Borylgruppe (4)
- Borylkomplexe (4)
- Boson (4)
- Breast cancer (4)
- Brief (4)
- Burkholderia pseudomallei (4)
- Bypass (4)
- Bypassoperation (4)
- C-C coupling (4)
- C-MYC (4)
- CAPM (4)
- CCI (4)
- CD150 (4)
- CD28 Superagonist (4)
- CD44 (4)
- CMR (4)
- CNV (4)
- CPT (4)
- CRP (4)
- CT angiography (4)
- CTLA-4 (4)
- Cancer genetics (4)
- Cannabinoide (4)
- Capital-Asset-Pricing-Modell (4)
- Carben (4)
- Carcinogenesis (4)
- Carotisstenose (4)
- Catecholamine (4)
- Cell culture (4)
- Central Asia (4)
- Cephalometry (4)
- Channelrhodopsin-2 (4)
- Charcot-Marie-Syndrom (4)
- Charged Aerosol Detection (4)
- Chemische Reinheit (4)
- Chemische Ökologie (4)
- Chemistry (4)
- Chemometrie (4)
- Chirality (4)
- Chloroquin (4)
- Chorioamnionitis (4)
- Chromosomenaberration (4)
- Climate Change (4)
- Clopidogrel (4)
- Cluster-Analyse (4)
- Cognition (4)
- Computerunterstütztes Lernen (4)
- Conditioning (4)
- Corporate Governance (4)
- Corpus amygdaloideum (4)
- Costa Rica (4)
- Craniosynostosis (4)
- Crowdsourcing (4)
- Cushing-Syndrom (4)
- Cushing’s syndrome (4)
- Cyanoborate (4)
- Cyclodextrin (4)
- Cyclophane (4)
- Cyclovoltammetrie (4)
- DCF (4)
- DCM (4)
- DFT calculations (4)
- DHEAS (4)
- DNA damage response (4)
- DNA transcription (4)
- DNA-Replikation (4)
- DNA-Schaden (4)
- DNA-binding proteins (4)
- DNS-Bindung (4)
- DRG (4)
- Darmflora (4)
- Darmkrebs (4)
- Dasatinib (4)
- Demokratie (4)
- Dendritic cell (4)
- Dentalkeramik (4)
- Design (4)
- Desmosom (4)
- Dexamethason (4)
- Diabetische Polyneuropathie (4)
- Diagnosis (4)
- Diborane(4) (4)
- Dictyostelium discoideum (4)
- Dienstgüte (4)
- Differentiation (4)
- Diffusions-MRT (4)
- Diffusionsverfahren <Halbleitertechnologie> (4)
- Digital Storytelling (4)
- Dimension 2 (4)
- Dimere (4)
- Dionaea muscipula (4)
- Dipolare Cycloaddition (4)
- Distributions (4)
- Diversity (4)
- Docetaxel (4)
- Doppelbindung (4)
- Drama (4)
- Duftstoff (4)
- Dunkle Materie (4)
- Duplikation (4)
- Dynamics (4)
- E. coli Nissle 1917 (4)
- ECG (4)
- EGF (4)
- EKG (4)
- EPR (4)
- Echtzeit (4)
- Effizienz (4)
- Eisenkomplexe (4)
- Eisenoxide (4)
- Electronic Commerce (4)
- Electroweak interaction (4)
- Elektrocochleographie (4)
- Elektromyographie (4)
- Elektronenspektroskopie (4)
- Elektronentransport (4)
- Elektrospinnen (4)
- Elliptische Differentialgleichung (4)
- Emotionserkennung (4)
- Endoprothese (4)
- Endosymbiont (4)
- Endothelbarriere (4)
- Endotheldysfunktion (4)
- Endothelium (4)
- Enrichement (4)
- Entstehung (4)
- Enzymersatztherapie (4)
- Ependymom (4)
- Epigenetics (4)
- Epitaxie (4)
- Epitaxy (4)
- Ereigniskorrelierte Potentiale (4)
- Erfahrung (4)
- Erhebungsinstrumente (4)
- Erneuerbare Energien (4)
- Erratum (4)
- Erwachsenenbildung (4)
- Erzählen (4)
- Essgewohnheit (4)
- Estradiol (4)
- Ethanol (4)
- Ethnografie (4)
- Euler equations (4)
- Europäische Zentralbank (4)
- Excitons (4)
- Expansion Microscopy (4)
- Extrakt (4)
- Extremwerttheorie (4)
- FDG (4)
- FKBP5 (4)
- FMRI (4)
- FSHD (4)
- Fahren (4)
- Fahrsimulation (4)
- Fake News (4)
- Fazialisparese (4)
- Fear (4)
- Feldeffekttransistor (4)
- Feminismus (4)
- Fertilität (4)
- Fettleber (4)
- Fettsäurestoffwechsel (4)
- Fettzelle (4)
- Fibroblasts (4)
- Finanzkrise (4)
- First Responder (4)
- Fließregulierungsmittel (4)
- Fluorescence Microscopy (4)
- Foamyvirus (4)
- Follikuläres Lymphom (4)
- Fortpflanzungsverhalten (4)
- Fotokatalyse (4)
- Foxp3 (4)
- Friedrich (4)
- Frühe Neuzeit (4)
- Fullerene (4)
- Funktionswerkstoff (4)
- G protein-coupled receptors (4)
- G proteins (4)
- G-Protein gekoppelte Rezeptor (4)
- G-Protein gekoppelter Rezeptor (4)
- GC-A (4)
- GVHD (4)
- Galliumarsenid-Bauelement (4)
- Galliumarsenidlaser (4)
- Gasionisationsdetektor (4)
- Gedächtnisbildung (4)
- Geflüchtete (4)
- Geisteswissenschaften (4)
- Geißel <Biologie> (4)
- Gelatine (4)
- Gelingensbedingungen (4)
- Gene regulation (4)
- Generalisierung (4)
- Genomschaden (4)
- Geobotanik ; Pflanzengeographie (4)
- Geophysik (4)
- Gesichtsschmerz (4)
- Gesprochene Sprache (4)
- Gesundheitsförderung (4)
- Gesundheitswesen (4)
- Glatte Muskulatur (4)
- Glioma (4)
- Glucocorticosteroidrezeptor (4)
- Glucosestoffwechsel (4)
- Glutamatrezeptor (4)
- Glutamin (4)
- Glutathion (4)
- Gram-positive bacteria (4)
- Graphene (4)
- Griechenland <Altertum> (4)
- Grundwasserneubildung (4)
- Grün fluoreszierendes Protein (4)
- Guanidinderivate (4)
- Gynäkologie (4)
- HFmrEF (4)
- HFpEF (4)
- HSM-sentence-test (4)
- Haftung (4)
- Halbleiterphysik (4)
- Hall, Stuart (4)
- Halothan (4)
- Handchirurgie (4)
- Handgelenk (4)
- Harnblasenkarzinom (4)
- Hautkrebs (4)
- Helicasen (4)
- Helicobacter (4)
- Hepatozelluläres Karzinom (4)
- Herstellung (4)
- Herzfunktion (4)
- Heterocyclen (4)
- Heubacillus (4)
- Hieracium (4)
- Hierarchy (4)
- Higgs (4)
- Hirnödem (4)
- Histone (4)
- Histopathologie (4)
- Hitzestress (4)
- Hochschule (4)
- Hochtemperatursupraleitung (4)
- Hornhaut (4)
- Hospitalismus <Hygiene> (4)
- Hsp90 (4)
- Hybridpolymer (4)
- Hybridpolymere (4)
- Hydrodynamik (4)
- Hydrolyse (4)
- Hyperaldosteronismus (4)
- Hypertrophische Herzmuskelkrankheit (4)
- Hyponatriämie (4)
- Hypoparathyreoidismus (4)
- Hypophosphatasia (4)
- Hämodynamik (4)
- Hämophilie A (4)
- Höhengradient (4)
- Höherkoordination (4)
- Hörstörung (4)
- Hörtest (4)
- Hüfte (4)
- Hüftendoprothetik (4)
- ICSI (4)
- IL-6 (4)
- Identifizierung (4)
- Illustration (4)
- Image Processing (4)
- Immunohistochemistry (4)
- Immunstimulation (4)
- Implantierbarer Kardioverter-Defibrillator (4)
- Inanspruchnahme (4)
- Infektionskrankheit (4)
- Informationskompetenz (4)
- Infrarot (4)
- Inhalation (4)
- Innate immunity (4)
- Insekt (4)
- Instabilität (4)
- Interaktionen (4)
- Interkulturelles Lernen (4)
- Interleukin 1-beta (4)
- Interleukin 13 (4)
- Interleukin 17 (4)
- Interleukin 8 (4)
- Internationalität (4)
- Internet der Dinge (4)
- Internet of Things (4)
- Invertase (4)
- Ionic Liquids (4)
- Ionisierende Strahlung (4)
- Iridiumkomplexe (4)
- Ischämische Präkonditionierung (4)
- Isolation (4)
- JIA (4)
- Japan (4)
- Judith <Book> (4)
- Jura (4)
- Jura <Geologie> (4)
- Kalium (4)
- Kalorimetrie (4)
- Karoo (4)
- Karst (4)
- KasA (4)
- Katalog (4)
- Kaufverhalten (4)
- Kilimandscharo (4)
- Kindergarten (4)
- Kinderpsychiatrie (4)
- Kindesalter (4)
- Klausur (4)
- Klonierung (4)
- Knie (4)
- Knochenbildung (4)
- Knochenkleber (4)
- Knochenzemente (4)
- Knorpelregeneration (4)
- Kognitive Entwicklung (4)
- Kohlenmonoxid (4)
- Kohärente Kontrolle (4)
- Kombinatorik (4)
- Kongestive Herzmuskelkrankheit (4)
- Kontinentales Tiefbohrprogramm (4)
- Koordinationsverbindungen (4)
- Koordinativ ungesättigte Verbindungen (4)
- Korrosion (4)
- Kosten (4)
- Kraftmikroskopie (4)
- Kraniometrie (4)
- Krankheitsverarbeitung (4)
- Krebstherapie (4)
- Kreuzreaktion (4)
- Kristallisation (4)
- Kristallwachstum (4)
- Kupfer (4)
- LC/MS (4)
- LINC complex (4)
- Lactate (4)
- Lagerungsplagiozephalus (4)
- Lamina (4)
- Lamine (4)
- Laminin (4)
- Langerhans cells (4)
- Langfristige Prognose (4)
- Laparoskopie (4)
- Laufzeit (4)
- Lebensalter (4)
- Leberresektion (4)
- Legionärskrankheit (4)
- Leistungssport (4)
- Lenalidomid (4)
- Lepidoptera (4)
- Leptin (4)
- Lernerfolg (4)
- Lernpsychologie (4)
- Lernverhalten (4)
- Leukozyt (4)
- Leukämie (4)
- Lewis acids (4)
- Lewis-Säure (4)
- LiDAR (4)
- Localization (4)
- Lopinavir (4)
- Loss of heterozygosity (4)
- Low-density-Lipoproteine (4)
- Lung cancer (4)
- Lungenembolie (4)
- Lymphogranulomatose (4)
- Lysosom (4)
- MALDI-MS (4)
- MALT (4)
- MCP-1 (4)
- MIBG (4)
- MIZ1 (4)
- MMB (4)
- MMP (4)
- MOLLI (4)
- MPEC (4)
- MPFL (4)
- MR (4)
- MR-Spektroskopie (4)
- MSCs (4)
- MTUS1 (4)
- Macrophages (4)
- Magnetoelektronik (4)
- Magnetohydrodynamik (4)
- Magnetpartikelbildgebung (4)
- Maisstärke (4)
- Malignes Lymphom (4)
- Mammographie (4)
- Massenmedien (4)
- Mechanismus (4)
- Medaka (4)
- Mediendidaktik (4)
- Medienkritik (4)
- Medienpädagogik (4)
- Medizinische Ausbildung (4)
- Mehrkriterielle Optimierung (4)
- Melodie (4)
- Meningococci (4)
- Mensch-Maschine-Interaktion (4)
- Menschenrechte (4)
- Mergers and Acquisitions (4)
- Mesenchymale Stammzelle (4)
- Mesopotamien (4)
- Metabolisches Syndrom (4)
- Metabolit (4)
- Metallkomplexe (4)
- Metallosupramolekulare Chemie (4)
- Metamorphose <Geologie> (4)
- Metformin (4)
- Mexiko (4)
- Microglia (4)
- Mikroarray (4)
- Mikrodialyse (4)
- Mikropartikel (4)
- Mikrosatelliteninstabilität (4)
- Mitotane (4)
- Mittelohr (4)
- Mixed Reality (4)
- Mixed-Methods (4)
- Miz1 (4)
- Mobilität (4)
- Modeling (4)
- Modelling (4)
- Models (4)
- Molekulare Bildgebung (4)
- Molekülphysik (4)
- Molybdän (4)
- Morbidität (4)
- Morbus Alzheimer (4)
- Mortality (4)
- Motorische Endplatte (4)
- Mund-Kiefer-Gesichts-Chirurgie (4)
- Mundhöhlenkarzinom (4)
- Muskel (4)
- Muskelatrophie (4)
- Mustererkennung (4)
- Mutagenese (4)
- Myasthenia gravis (4)
- Mycobacterium tuberculosis (4)
- Myelin (4)
- Mykobakterien (4)
- Mykose (4)
- Mäuse (4)
- NAD (4)
- NET (4)
- NF-kappa-B (4)
- NF-κB (4)
- NFkB (4)
- NFkappaB (4)
- NGF (4)
- NGS (4)
- NMDA-Rezeptor (4)
- NSSI (4)
- NT-proBNP (4)
- NaV1.9 (4)
- Naphthylisochinolin-Alkaloide (4)
- Natur (4)
- Natural products (4)
- Nausea (4)
- Navigation (4)
- Nebenniereninsuffizienz (4)
- Nebenwirkung (4)
- Nebenwirkungen (4)
- Nephrotoxizität (4)
- Nervennetz (4)
- Nestbau (4)
- Netzwerkanalyse (4)
- Neugeborenenhörscreening (4)
- Neurochirurgie (4)
- Neuromelanin (4)
- Neurons (4)
- Neurospora crassa (4)
- Neurotrophic factors (4)
- Neutrophiler Granulozyt (4)
- Nibelungenlied (4)
- Nichtglatte Optimierung (4)
- Nickelverbindungen (4)
- Nicotiana tabacum (4)
- Nitratreduktase (4)
- Nonlinear Dynamics (4)
- Numerisches Modell (4)
- Oberflächenzustand (4)
- Oligomere (4)
- Omarthrose (4)
- Oncostatin M (4)
- Online-Handel (4)
- Onlinehandel (4)
- OpenSpaceAlps (4)
- Operationstechnik (4)
- Optical spectroscopy (4)
- Organic Chemistry (4)
- Organischer Feldeffekttransistor (4)
- Organoid (4)
- Ormocer (4)
- Orthopädie (4)
- Osteoblasten (4)
- Osteoinduction (4)
- Osteopontin (4)
- Osteotomie (4)
- Overlay-Netz (4)
- Oxidative Stress (4)
- Oxidative stress (4)
- PAK (4)
- PBMC (4)
- PEG (4)
- PER (4)
- PI3K (4)
- PKA (4)
- PSA (4)
- PSMA-RADS (4)
- PTCA (4)
- PTCDA (4)
- PTEN (4)
- PTH (4)
- Paläoklima (4)
- Palökologie (4)
- Parallelkorpus (4)
- Partielle Differentialgleichung (4)
- Pathogenitätsinsel (4)
- Pathogens (4)
- Pathway (4)
- Patient (4)
- Patienten (4)
- Patientenschulung (4)
- Pe (4)
- Perception (4)
- Performance (4)
- Peripheres Nervensystem (4)
- Perylene Bisimide (4)
- Pflanzeninhaltsstoff (4)
- Pharmacokinetics (4)
- Phasenumwandlung (4)
- Phenomenology (4)
- Pheromone (4)
- Phobie (4)
- Phosphatidylinositolkinase <Phosphatidylinositol-3-Kinase> (4)
- Phosphoglykolatphosphatase (4)
- Phospholipide (4)
- Phosphor (4)
- Photorezeptor (4)
- Photostrom (4)
- Phthalocyanin (4)
- Physikalische Eigenschaft (4)
- Phänologie (4)
- Phäochromozytom (4)
- Placebo (4)
- Plants (4)
- Plasmon (4)
- Pleuraempyem (4)
- Pollination (4)
- Polyadenylierung (4)
- Polyethylenglykole (4)
- Pontryagin maximum principle (4)
- Prehistory (4)
- Prescriptive Analytics (4)
- Priming (4)
- Prion (4)
- Private Altersversorgung (4)
- Professionalisierung (4)
- Promotor <Genetik> (4)
- Propriozeption (4)
- Prosodie (4)
- Prostaglandin E2 (4)
- Prostata (4)
- Protein-Protein-Interaktion (4)
- Proteinfaltung (4)
- Proteininteraktion (4)
- Proteinkinase B (4)
- Proteinsynthese (4)
- Proteintyrosinphosphatase (4)
- Präparation (4)
- Pseudomonas (4)
- Psychische Gesundheit (4)
- Psychobiologie (4)
- Pulswellengeschwindigkeit (4)
- Punktion (4)
- Punktwolke (4)
- Puppenhandillusion (4)
- Purkinje cells (4)
- Pyridoxalphosphat (4)
- Pyrrolizidinalkaloide (4)
- QSAR (4)
- QoE (4)
- Quadrocopter (4)
- Quality of Life (4)
- Quantendraht (4)
- Quantenfeldtheorie (4)
- Quantenkaskadenlaser (4)
- Quantum information (4)
- RCT (4)
- RIXS (4)
- RNA modification (4)
- RNA-Seq (4)
- RNS-Bindungsproteine (4)
- RSK (4)
- RZUW (4)
- Rachitis (4)
- Radioonkologie (4)
- Randqualität (4)
- Rashba effect (4)
- Raumwahrnehmung (4)
- Recht (4)
- Rechtsmedizin (4)
- Regelung (4)
- Regenwald (4)
- Register (4)
- Registrierung <Bildverarbeitung> (4)
- Regressionsanalyse (4)
- Reifung (4)
- Rekombinantes Protein (4)
- Rekrutierung (4)
- Relaxation (4)
- Relaxationszeit (4)
- Reliabilität (4)
- Remote sensing (4)
- Renormierungsgruppe (4)
- Repräsentation (4)
- Ressourcenmanagement (4)
- Restaurative Zahnmedizin (4)
- Reverse Transkriptase (4)
- Rhabdomyosarkom (4)
- Rheumatismus (4)
- Rheumatologie (4)
- Rho-Proteine (4)
- Robotics (4)
- Romanische Sprachen (4)
- Rotatorenmanschettenruptur (4)
- Roux-en-Y gastric bypass surgery (4)
- Ruthenium complexes (4)
- Röntgen-Kleinwinkelstreuung (4)
- Röntgendiffraktometrie (4)
- SAS <Programm> (4)
- SLC2A3 (4)
- SOAT1 (4)
- SOX9 (4)
- SPRED2 (4)
- SQH method (4)
- Saccharose (4)
- Sahara (4)
- Sahel (4)
- Salmonella Typhimurium (4)
- Salzhydratschmelze (4)
- Sap47 (4)
- Sauerstoff (4)
- Schaf (4)
- Schlaf (4)
- Schnarchen (4)
- Schulklasse (4)
- Schulterendoprothetik (4)
- Schwein (4)
- Schweiz (4)
- Schwere-Fermionen-System (4)
- Schüler (4)
- Score (4)
- Sekundärkrankheit (4)
- Sekundärprävention (4)
- Sekundärstruktur (4)
- Selbstassemblierung (4)
- Selenoproteine (4)
- Sensitivity (4)
- Serotoninstoffwechsel (4)
- Serum (4)
- Sevofluran (4)
- Sex determination (4)
- Signaling (4)
- Silanole (4)
- Silicone (4)
- Silikon (4)
- Simulator (4)
- Sintern (4)
- SnRK1 (4)
- Social Media (4)
- Softwareentwicklung (4)
- Soziale Wahrnehmung (4)
- Sozialphilosophie (4)
- Speicheldrüse (4)
- Spessart (4)
- Sphingolipidstoffwechsel (4)
- Sphingomyelinphosphodiesterase (4)
- Sponges (4)
- Sprachverständnistest (4)
- Staatliche Museen zu Berlin. Antikensammlung (4)
- Stabilisierung (4)
- Standortfaktor (4)
- Staphylococcus epidermis (4)
- Statine (4)
- Stereoselektivität (4)
- Stereotyp (4)
- Steuern (4)
- Stickstoff (4)
- Stimme (4)
- Strategie (4)
- Stratigraphie (4)
- Straßenverkehr (4)
- Stressinkontinenz (4)
- Strukturanalyse (4)
- Störgeräusch (4)
- Supramolekulare Struktur (4)
- Surgery (4)
- Synapsine (4)
- Synaptonemal complex (4)
- Synuclein <alpha-> (4)
- System (4)
- Systematische Übersichtsarbeit (4)
- T Zellen (4)
- T-Zell-Aktivierung (4)
- T-Zell-Lymphom (4)
- TFIIH (4)
- TNAP (4)
- TNF receptor superfamily (4)
- TNFR1 (4)
- Tandem-Massenspektrometrie (4)
- Tandem-Reaktion (4)
- Telekommunikationsnetz (4)
- Temperaturabhängigkeit (4)
- Textsorte (4)
- Th17 (4)
- Theoretische Ökologie (4)
- Theorie (4)
- Theory of Mind (4)
- Thymom (4)
- Tiere (4)
- Transfer (4)
- Transforming Growth Factor (4)
- Transgenic mice (4)
- Transkriptionsfaktoren (4)
- Translation <Genetik> (4)
- Translokation (4)
- Transpiration <Pflanzen> (4)
- Transplantatabstoßung (4)
- Triarylborane (4)
- Trypanosomiasis (4)
- Tubulin (4)
- Tumorerkrankungen (4)
- Typ 1 (4)
- USP28 (4)
- UV/Vis spectroscopy (4)
- Ultraschnelle Photochemie (4)
- Ultraviolett-Photoelektronenspektroskopie (4)
- Umweltrecht (4)
- Unabhängigkeit (4)
- Unlauterer Wettbewerb (4)
- Unternehmenstheorie (4)
- Ureaplasma parvum (4)
- Urheberrecht (4)
- Urin (4)
- Urämietoxine (4)
- VEP (4)
- VMAT (4)
- Vaccinia Virus (4)
- Validität (4)
- Vektor <Genetik> (4)
- Velocity-Map-Imaging (4)
- Verfassungsrecht (4)
- Verhaltensstörung (4)
- Verkapselung (4)
- Verkehrssicherheit (4)
- Verlauf (4)
- Verletzung (4)
- Versorgungsqualität (4)
- Verzeichnis (4)
- Viren (4)
- Vitamin D3 (4)
- Vitamin-D-Mangel (4)
- Volkskunde (4)
- Vorhofflimmern (4)
- Vorläuferzelle (4)
- Völkerrecht (4)
- Wachstumsfaktoren (4)
- Wald (4)
- Wasserhaushalt (4)
- Wasseroxidation (4)
- Wasserstoffperoxid (4)
- Wassertransport (4)
- Weimarer Republik (4)
- Wellenpaket (4)
- Wide-gap-Halbleiter (4)
- William (4)
- Williams, Raymond (4)
- Wirbelsäulenverletzung (4)
- Wirkmechanismus (4)
- Wirkstoff-Rezeptor-Bindung (4)
- Wirkstoffe (4)
- Wirkung (4)
- Wirt (4)
- Wirtschaftsinformatik (4)
- Wirtszelle (4)
- Wissenschaftlicher Nachwuchs (4)
- Wissenschaftssprache (4)
- Wissensrepräsentation (4)
- Wittig-Reaktion (4)
- Wnt (4)
- Wnt-Proteine (4)
- Wolfgang Amadeus (4)
- Wolframkomplexe (4)
- XML (4)
- Xmrk (4)
- Yoga (4)
- Z boson (4)
- Zahnimplantat (4)
- Zeitaufgelöste Spektroskopie (4)
- Zeitauflösung (4)
- Zeitreihe (4)
- Zellkontakt (4)
- Zement (4)
- Zinkoxid (4)
- Zufriedenheit (4)
- Zwangsstörung (4)
- Zweisprachigkeit (4)
- Zwitterion (4)
- abscisic acid (4)
- accumulation (4)
- action (4)
- active galactic nuclei (4)
- acute respiratory distress syndrome (4)
- adhesion molecules (4)
- adjuvant treatment (4)
- adrenal gland (4)
- adulte Neurogenese (4)
- adulthood (4)
- affect (4)
- age-related macular degeneration (4)
- agency (4)
- agroecology (4)
- albumin (4)
- alkaline phosphatase (4)
- allogene Stammzelltransplantation (4)
- allogeneic hematopoietic stem cell transplantation (4)
- alpha-synuclein (4)
- amyotrophic-lateral-sclerosis (4)
- analgesia (4)
- aneurysm (4)
- angeborenes Immunsystem (4)
- animals (4)
- anion channel (4)
- antagonist (4)
- antagonists (4)
- antibacterial (4)
- antifungal susceptibility (4)
- antifungals (4)
- antimicrobial (4)
- antioxidant (4)
- antiretroviral therapy (4)
- antisense RNA (4)
- apis mellifera (4)
- appendicitis (4)
- aquaporin (4)
- arteriosclerosis (4)
- arthroplasty (4)
- arthropods (4)
- associative learning (4)
- athletes (4)
- atopic dermatitis (4)
- attention-deficit/hyperactivity disorder (ADHD) (4)
- attentional bias (4)
- auditory pathway (4)
- autoantigen (4)
- autoimmune (4)
- auxin (4)
- avatars (4)
- awareness (4)
- axonal damage (4)
- bee decline (4)
- beta diversity (4)
- bevacizumab (4)
- bilingualism (4)
- binding analysis (4)
- biochemistry (4)
- biodiversity conservation (4)
- biofilm formation (4)
- biofilms (4)
- biological models (4)
- biologics (4)
- biomass (4)
- birds (4)
- bisphosphonates (4)
- blazar (4)
- bleeding (4)
- body composition (4)
- bone adhesive (4)
- bone metastases (4)
- bone substitute (4)
- bone-mineral density (4)
- borylenes (4)
- brain edema (4)
- bridging (4)
- cAAC (4)
- calcium phosphate cement (4)
- cancer genomics (4)
- cancer patients (4)
- candida albicans (4)
- capsaicin (4)
- carbanion (4)
- carbohydrates (4)
- carbon (4)
- carborane (4)
- cardiac magnetic resonance imaging (4)
- cardiac metabolism (4)
- cardiorespiratory fitness (4)
- cardiovascular genetics (4)
- care (4)
- cell-cycle arrest (4)
- cervical dystonia (4)
- characterization (4)
- chemotaxis (4)
- chiral separation (4)
- chlamydia trachomatis (4)
- chondrogenesis (4)
- chondrogenic differentiation (4)
- cirrhosis (4)
- cluster analysis (4)
- cochlea (4)
- colon (4)
- colony-stimulating factor (4)
- combination therapy (4)
- comparative genomic hybridization (4)
- compensation (4)
- complement system (4)
- complication (4)
- computational chemistry (4)
- consciousness (4)
- consortium (4)
- context (4)
- convolutional neural network (4)
- convolutional neural networks (4)
- cooperation (4)
- copy number variation (4)
- corneal confocal microscopy (4)
- corporate assessment (4)
- corporate law (4)
- corpus linguistics (4)
- costs (4)
- critical care (4)
- crosstalk (4)
- crowdsensing (4)
- crystallography (4)
- culture (4)
- cycloaddition (4)
- cysteine protease (4)
- deadwood enrichment (4)
- deafness (4)
- death receptors (4)
- decellularization (4)
- decoherence (4)
- deficiency (4)
- definition (4)
- dehydrocoupling (4)
- dental implants (4)
- dermatology (4)
- desflurane (4)
- desmosome (4)
- desmosomes (4)
- detrended fluctuation analysis (4)
- diabetic nephropathy (4)
- diborane (4)
- diboranes (4)
- diboration (4)
- diffuse large B-cell lymphoma (4)
- diffusion tensor imaging (4)
- dimerization (4)
- disease severity (4)
- drosophila (4)
- drug metabolism (4)
- dynamic (4)
- dysgnathia (4)
- dyslexia (4)
- ecological intensification (4)
- economic growth (4)
- economics (4)
- ecosystem function (4)
- ecosystem service (4)
- editorial (4)
- electrocardiography (4)
- electroencephalogram (4)
- electrohydrodynamic (4)
- electron (4)
- electron tomography (4)
- electron transfer (4)
- emotional regulation (4)
- emotionale Kompetenz (4)
- endurance exercise (4)
- entanglement (4)
- epithelium (4)
- essential genes (4)
- estrogen receptor (4)
- evolutionary genetics (4)
- excited states (4)
- exciton coupling (4)
- exciton dynamics (4)
- experimental stroke (4)
- exposure therapy (4)
- extracorporeal membrane oxygenation (4)
- extrazelluläre Matrix (4)
- face perception (4)
- face processing (4)
- failure (4)
- feminism (4)
- ferroptosis (4)
- fertility (4)
- fibrin (4)
- fibroblast (4)
- fibronectin (4)
- fish model (4)
- fitness (4)
- flagellum (4)
- flow (4)
- fluorescent protein (4)
- fluoroarene (4)
- follow up (4)
- foot (4)
- forensic neurotraumatology (4)
- forest ecology (4)
- fullerenes (4)
- functional analysis (4)
- functional characterization (4)
- functional diversity (4)
- functionalization (4)
- fungal structure (4)
- gait analysis (4)
- gait initiation (4)
- games (4)
- genetic loci (4)
- genome annotation (4)
- geoarchaeology (4)
- geography (4)
- gingivitis (4)
- globalization (4)
- glucose transporter (4)
- glutamine (4)
- gynecology (4)
- habitats (4)
- halothane (4)
- head (4)
- healthy volunteers (4)
- hematology (4)
- hepatitis C virus (4)
- hernia (4)
- hip fracture (4)
- homologous recombination (4)
- host cells (4)
- humanized mice (4)
- hybrid materials (4)
- hydrocarbons (4)
- hydrodynamics (4)
- hydrogen bonding (4)
- hydrolysis (4)
- hydroxyapatite (4)
- hypercortisolism (4)
- hypofractionation (4)
- iNOS (4)
- iPSC (4)
- image processing (4)
- imaging techniques (4)
- immune checkpoint blockade (4)
- immunohistochemistry techniques (4)
- immunosenescence (4)
- individual-based model (4)
- induction (4)
- infant (4)
- influenza A virus (4)
- innate immune response (4)
- inpatient rehabilitation (4)
- insect brain (4)
- insulin receptor (4)
- intellectual disability (4)
- intensive care (4)
- interoception (4)
- intervention (4)
- interview (4)
- intestinal barrier (4)
- invasive aspergillosis (4)
- invasive fungal infection (4)
- invasive pulmonary aspergillosis (4)
- ion channels (4)
- ionic liquids (4)
- jet energy resolution (4)
- kardiale Hypertrophie (4)
- kidney function (4)
- language development (4)
- learning curve (4)
- left ventricular hypertrophy (4)
- lenalidomide (4)
- leukemic cells (4)
- ligands (4)
- lines (4)
- linguistics (4)
- linkage (4)
- lipid bilayer (4)
- lipidomics (4)
- literature (4)
- living cells (4)
- locus coeruleus (4)
- lokale Selbstregelungen (4)
- loneliness (4)
- mRNA expression (4)
- macrocycles (4)
- macular degeneration (4)
- maize (4)
- major depressive disorder (4)
- malignant melanoma (4)
- mammalian cells (4)
- man-computer interface (4)
- mandible (4)
- manganese (4)
- marine sponge (4)
- mass (4)
- mathematics (4)
- matrix metalloproteinase (4)
- measurement (4)
- medical research (4)
- medical students (4)
- medullary thyroid carcinoma (4)
- melatonin (4)
- melody (4)
- melt electrowriting (MEW) (4)
- memory B cells (4)
- men (4)
- meningioma (4)
- meningococci (4)
- mesenchymal stromal cells (4)
- metabolic adaptation (4)
- metabolic test (4)
- miRNAs (4)
- microRNAs (4)
- microarrays (4)
- microcavity (4)
- micronucleus test (4)
- middle ear (4)
- mindfulness (4)
- minimally invasive surgery (4)
- mitochondrial DNA (4)
- modulation (4)
- molecular modeling (4)
- molecular modelling (4)
- molecular recognition (4)
- molybdenum (4)
- mood (4)
- morality (4)
- morphometry (4)
- mtDNA (4)
- multi-fluid mixture (4)
- multisensory integration (4)
- multisensory processing (4)
- musculoskeletal system (4)
- mutagenesis (4)
- mutagenicity (4)
- myasthenia gravis (4)
- myelination (4)
- myocardial perfusion (4)
- myofibroblast (4)
- n-Halbleiter (4)
- nNOS (4)
- natural enemies (4)
- natural language processing (4)
- networks (4)
- neural stem cell (4)
- neural stem cells (4)
- neuroimaging (4)
- neuroimmunology (4)
- neurotrophic factors (4)
- new species (4)
- nociception (4)
- non-covalent interactions (4)
- noradrenaline (4)
- norepinephrine transporter (4)
- nuclear magnetic resonance (4)
- oligodendrocytes (4)
- oligomerization (4)
- ontology (4)
- opioids (4)
- optical coherence tomography (4)
- organic (4)
- organic photovoltaics (4)
- organoid (4)
- orientation (4)
- osteoblast (4)
- osteotomy (4)
- outbreak (4)
- oxidative addition (4)
- oxygenation (4)
- p38 (4)
- paediatrics (4)
- palliative care (4)
- parallel corpus (4)
- parasite (4)
- parasitology (4)
- parathyroid (4)
- particle physics (4)
- pathology (4)
- patient (4)
- patient blood management (4)
- pentacoordinate (4)
- peptides (4)
- performance monitoring (4)
- periodic catatonia (4)
- perioperative management (4)
- periprothetische Infektion (4)
- personality traits (4)
- pharmacogenetics (4)
- pharmacotherapy (4)
- phase transition (4)
- phase transitions and critical phenomena (4)
- pheromone (4)
- phosphate (4)
- phosphoantigen (4)
- phosphorescence (4)
- photodissociation (4)
- photodynamic therapy (4)
- photonic devices (4)
- phytic acid (4)
- phytoprostanes (4)
- plant cuticle (4)
- plasma (4)
- plasmonics (4)
- platinum (4)
- pluripotency (4)
- political discourse (4)
- pollution (4)
- polycycles (4)
- polygenic risk score (4)
- polymer (4)
- polymerization (4)
- population genetics (4)
- positron-emission-tomography (4)
- post-traumatic stress disorder (4)
- postoperative Komplikationen (4)
- principal component analysis (4)
- prognostic factor (4)
- prognostic value (4)
- propofol (4)
- protease inhibitor (4)
- protein structure (4)
- protein synthesis (4)
- protein-protein interaction (4)
- proteome (4)
- psychische Belastung (4)
- psycho-oncology (4)
- psychophysics (4)
- punishment (4)
- purification (4)
- quality control (4)
- quality indicators (4)
- quantum control (4)
- radar (4)
- radiation therapy (4)
- radiochemotherapy (4)
- radiology (4)
- radionuclide therapy (4)
- rainforest (4)
- reaction mechanisms (4)
- reaction time (4)
- reactivity (4)
- reading (4)
- real-time (4)
- recommendations (4)
- red blood cells (4)
- regulator (4)
- regulator genes (4)
- regulatorische T Zellen (4)
- regulatory T-cells (4)
- religion (4)
- renal failure (4)
- reoperation (4)
- reporter gene (4)
- reproduction (4)
- resonant tunneling diode (4)
- response regulator (4)
- results (4)
- retrospektiv (4)
- reverse transcriptase (4)
- rheology (4)
- rhodium (4)
- rhodopsin (4)
- ribosomal RNA (4)
- ribosome biogenesis (4)
- risk assessment (4)
- root (4)
- rotation (4)
- ruthenium complexes (4)
- saccades (4)
- salivary gland (4)
- saproxylic beetles (4)
- scaling (4)
- scanning tunneling microscopy (4)
- schistosomiasis (4)
- score (4)
- secondary metabolites (4)
- selenium (4)
- self-regulation (4)
- sequence analysis (4)
- sequence motif analysis (4)
- sex (4)
- sex determination (4)
- shRNA (4)
- shape (4)
- signalling pathways (4)
- singlet oxygen (4)
- skin cancer (4)
- sleep bruxism (4)
- small intestine (4)
- smartwatch (4)
- soccer (4)
- social media (4)
- social systems (4)
- specialization (4)
- speciation (4)
- speech (4)
- sperm (4)
- spermatogenesis (4)
- spermiogenesis (4)
- sphingomyelinase (4)
- spillover (4)
- spin injection (4)
- spleen (4)
- spoken language (4)
- standardization (4)
- startle reflex (4)
- statins (4)
- stemness (4)
- stent (4)
- stereogen (4)
- stereogenic (4)
- stereoselektive Synthese (4)
- stimulation (4)
- strain rate (4)
- streptomyces (4)
- streptozotocin (4)
- stress response (4)
- strong coupling (4)
- struvite (4)
- substantia nigra (4)
- sulfur (4)
- supramolekulare Chemie (4)
- surface water (4)
- surgical and invasive medical procedures (4)
- surgical oncology (4)
- surveillance (4)
- survival analysis (4)
- sustained fear (4)
- synapses (4)
- synaptonemal complex (4)
- synthetic biology (4)
- systemic sclerosis (4)
- systems (4)
- task switching (4)
- theory of mind (4)
- thermal conductivity (4)
- thiol-ene (4)
- thromboembolism (4)
- thrombopoiesis (4)
- thymic carcinoma (4)
- thyroid (4)
- time series analysis (4)
- toe (4)
- toll-like receptors (4)
- tomato (4)
- top quark mass (4)
- topology (4)
- total knee replacement (4)
- toxicology (4)
- trabecular meshwork (4)
- transactivation (4)
- transcranial magnetic stimulation (4)
- transcriptome analysis (4)
- transient absorption spectroscopy (4)
- transient ischemic attack (4)
- transition metal complex (4)
- transition metal complexes (4)
- transposable elements (4)
- triarylamine (4)
- triarylborane (4)
- troponin (4)
- trypanosoma (4)
- tryptophan (4)
- tumor heterogeneity (4)
- tumor suppressor gene (4)
- tumorigenesis (4)
- tungsten (4)
- tyrosine kinase (4)
- ultimatum game (4)
- ultrafast photochemistry (4)
- ultrastructure (4)
- unconscious processing (4)
- urinary tract infection (4)
- user experience (4)
- validity (4)
- valuation of a company (4)
- vasculogenesis (4)
- velocity (4)
- vertical transmission (4)
- vesicles (4)
- viability (4)
- virotherapy (4)
- viruses (4)
- visual attention (4)
- visual perception (4)
- vitamin B6 (4)
- vitamin C (4)
- wall shear stress (4)
- wax (4)
- x (4)
- xxx (4)
- youth (4)
- zinc (4)
- zinc oxide (4)
- zinc oxide nanoparticles (4)
- Ästhetik (4)
- Östrogenrezeptor (4)
- Übelkeit (4)
- Überexpression (4)
- 16S rRNA (3)
- 18F-DCFPyL (3)
- 18F-FDG PET/CT (3)
- 18F-LMI1195 (3)
- 3 D bioprinting (3)
- 3D models (3)
- 3D powder printing (3)
- 3D scaffolds (3)
- 3D-Stereophotogrammetrie (3)
- 3D-Zellkultur (3)
- 4-0xadiazin-6-ones (3)
- 5-HT1A (3)
- 5-HT2C (3)
- 5-HTT (3)
- 5-Methylcytosine (3)
- 5-fluorouracil (3)
- A-priori-Wissen (3)
- A1 (3)
- ABR (3)
- ACE (3)
- ADP (3)
- AKT (3)
- AML (3)
- ARIA (3)
- ASC (3)
- Abschirmung (3)
- Absolute Configuration (3)
- Acetylcholinesterase (3)
- Acetylcholinrezeptor (3)
- Acetylsalicylsäure (3)
- Acne inversa (3)
- Actinoide (3)
- Actinomycetes (3)
- Adaptation (3)
- Adaptive Optics (3)
- Adaptive Optik (3)
- Adaptivregelung (3)
- Adaptorproteine (3)
- Additive Fertigung (3)
- Adenom-Karzinom-Sequenz (3)
- Adhesion (3)
- Adhäsine (3)
- Adrenalin (3)
- Adrenerger Rezeptor (3)
- Advanced Analytics (3)
- Advanced Glycation Endproducts (3)
- Adventitia (3)
- Affenimmundefizienzvirus (3)
- Age (3)
- Agency (3)
- Aging (3)
- Aktiengesellschaft (3)
- Aktienrecht (3)
- Aktin-Zytoskelett (3)
- Aktionspotenzial (3)
- Aktivität (3)
- Akupunktur (3)
- Akute lymphatische Leukämie (3)
- AlGaAs (3)
- Albino rats (3)
- Albumin (3)
- Aldehyde (3)
- Aldosteronantagonist (3)
- Algorithmische Geometrie (3)
- Alkaloid (3)
- Alkaloide (3)
- Allgemeine Entzündungsreaktion (3)
- Allgemeine atmosphärische Zirkulation (3)
- Allogeneic stem cell transplantation (3)
- Alopecia areata (3)
- Altersbestimmung (3)
- Alterssicherung (3)
- Altertum (3)
- Aluminium (3)
- Ambulante Behandlung (3)
- Ameisenstaat (3)
- Aminosäure (3)
- Amisulprid (3)
- Amphibian oocytes (3)
- Amphiphile Verbindungen (3)
- Amplitude (3)
- Amyloid <beta-> (3)
- Amyloidose (3)
- Anastomose (3)
- Anastomoseninsuffizienz (3)
- Anatomie (3)
- Andrea (Komponist) (3)
- Angewandte Mathematik (3)
- Angewandte Psychologie / Zeitschrift / Experimentelle Psychologie (3)
- Angiographie (3)
- Angiotensin (3)
- Angola (3)
- Anion (3)
- Anisotropie (3)
- Anthracenderivate (3)
- Anthropocene (3)
- Antibiotikatherapie (3)
- Antibodies (3)
- Antiferromagnetismus (3)
- Antigen CD22 (3)
- Antimalariamittel (3)
- Antimikrobielle Peptide (3)
- Antimykotika (3)
- Antimykotikaresistenz (3)
- Antipsychotika (3)
- Antworthemmung (3)
- Antwortverhalten (3)
- Anästhetikum (3)
- Apherese (3)
- Aplysina aerophoba (3)
- Apobec (3)
- Araneae (3)
- Arbeit (3)
- Arbeitsplatz (3)
- Arctic (3)
- Arginin (3)
- Aromastoff (3)
- Aromaten (3)
- Aromatically annulated triquinacenes (3)
- Aromatisch anellierte Triquinacene (3)
- Array (3)
- Arrhythmie (3)
- Art (3)
- Arthroplasty (3)
- Artificial Intelligence (3)
- Aseptische Lockerung (3)
- Association study (3)
- Assyriologie (3)
- Asteraceae (3)
- Atemwege (3)
- Atorvastatin (3)
- Atta vollenweideri (3)
- Attika (3)
- Attraktivität (3)
- Aufklärungsgespräch (3)
- Aufmerksamkeitsprozesse (3)
- Augendruck (3)
- Ausgrabung (3)
- Auslauftrichter (3)
- Ausländer (3)
- Ausstellung (3)
- Auswertung (3)
- Authentizität (3)
- Autismus (3)
- Autoantibodies (3)
- Automatische Klassifikation (3)
- Automatisiertes Fahren (3)
- Autonomes Fahrzeug (3)
- Autonomous UAV (3)
- Autophagie <Physiologie> (3)
- Autoradiography (3)
- Außenhandel (3)
- Avatar <Informatik> (3)
- B-cell (3)
- BIS (3)
- BL-Lacertae-Objekt (3)
- BN compounds (3)
- BP180 (3)
- BRAF mutation (3)
- Bacillus anthracis (3)
- Bacterial infection (3)
- Baden (3)
- Bakteriophagen (3)
- Bandwürmer (3)
- Bariatrische Chirurgie (3)
- Basalganglien (3)
- Basilarmembran (3)
- Basketball (3)
- Batterie (3)
- Bauchwandhernie (3)
- Bayesian classifier (3)
- Bcl-2-Proteinfamilie (3)
- Bedeutung (3)
- Bedürfnis (3)
- Befestigungskomposit (3)
- Behaviour (3)
- Benchmarking (3)
- Benn, Gottfried (3)
- Berechnungskomplexität (3)
- Bernasconi (3)
- Beruf (3)
- Beryllium (3)
- Beschleunigungssensor (3)
- Bestandsmanagement (3)
- Bestärkendes Lernen <Künstliche Intelligenz> (3)
- Bewegung (3)
- Bewegungssehen (3)
- Bewegungsstörung (3)
- Bewertung (3)
- Bewältigung (3)
- Bias (3)
- Biene <Gattung> (3)
- Bienenwolf (3)
- Big Data (3)
- Bild (3)
- Bilderbuch (3)
- Bildqualität (3)
- Bildrekonstruktion (3)
- Bindegewebe (3)
- Biodistribution (3)
- Biofabrikation (3)
- Biografie (3)
- Biographieforschung (3)
- Bioinks (3)
- Biokinetics (3)
- Biologische Aktivität (3)
- Biologisches Material (3)
- Biomarkers (3)
- Biomedical engineering (3)
- Biomedicine (3)
- Bioprinting (3)
- Biosensor (3)
- Biosphärenreservat (3)
- Biotechnologie (3)
- Bipolare Störung (3)
- Biradicals (3)
- Blickbewegung (3)
- Blochmannia (3)
- Blockchain (3)
- Blood-brain barrier (3)
- Bluthochdruck (3)
- Blutverlust (3)
- Bone marrow transplantation (3)
- Bone morphogenetic protein-2 (3)
- Bordetella bronchiseptica (3)
- Borirene (3)
- Borkomplexe (3)
- Borreliose (3)
- Borylentransfer (3)
- Bosons (3)
- Brachytherapie (3)
- Brackets (3)
- Brain-computer interface (3)
- Bridging (3)
- Brombeere (3)
- Brownsche Bewegung (3)
- Bruchfläche (3)
- Buchdruck (3)
- Bundeswehr (3)
- Bupivacain (3)
- Burkholderia (3)
- Business Intelligence (3)
- Butyrate (3)
- C/EBP (3)
- C5aR1 (3)
- CA3 (3)
- CAAC (3)
- CAD/CAM (3)
- CAR T cell (3)
- CAR T cells (3)
- CCL2 (3)
- CCR2 (3)
- CCR7 (3)
- CD22 (3)
- CD23 (3)
- CD27 (3)
- CD39 (3)
- CD4(+) (3)
- CD4+ T cells (3)
- CD40L (3)
- CD73 (3)
- CD8 T cell (3)
- CD8+ T cells (3)
- CD8+ T-Zellen (3)
- CD9 (3)
- CDH13 (3)
- CEA (3)
- CGH (3)
- CMT (3)
- CNO (3)
- CO2 (3)
- COVID-19 pandemic (3)
- COVID‐19 (3)
- CRISPR Cas9 (3)
- CRMO (3)
- CTGF (3)
- CVD (3)
- CYP11B2 (3)
- Calcium Imaging (3)
- Calcium-bindende Proteine (3)
- Calciumhydroxid (3)
- Calciumphosphatzemente (3)
- Calciumtransport (3)
- Calibration (3)
- Camerloher (3)
- Capsaicin (3)
- Carbenoide (3)
- Carcino-embryonales Antigen (3)
- Carcinogenicity (3)
- Carcinogens (3)
- Cardiomyopathy (3)
- Carrier-Proteine (3)
- Cas9 (3)
- CaseTrain (3)
- Caspase (3)
- Caspr (3)
- Cathepsin (3)
- CdSe (3)
- CdTe (3)
- CePt5 (3)
- Cell cycle (3)
- Cells (3)
- Central nervous system (3)
- Ceramid (3)
- Cerebellar cortex (3)
- Cerebrospinal fluid (3)
- Chaos (3)
- Chaostheorie (3)
- Chaperone (3)
- Chemieunterricht (3)
- Chemische Kommunikation (3)
- Chemokin CXCL10 (3)
- Chemokinrezeptor (3)
- Chimärismus (3)
- Chirp (3)
- Cholesterinstoffwechsel (3)
- Cholinesteraseinhibitor (3)
- Chondrozyten (3)
- Chromosomes (3)
- Chronisch-myeloische Leukämie (3)
- Circadian Rhythms (3)
- Circular Dichroism (3)
- Circular dichroism (3)
- Classification (3)
- Cluster (3)
- Co-culture (3)
- Cochlea-Implantat (3)
- Coexpression (3)
- Coffein (3)
- Coherent control (3)
- Coleoptera (3)
- Collagen (3)
- Colorectal Cancer (3)
- Comorbidity (3)
- Complexity (3)
- Computer Vision (3)
- Computerspiel (3)
- Conference (3)
- Coping (3)
- Copula (3)
- Coulomb-Blockade (3)
- Cranio-Corpo-Graphie (3)
- Creation (3)
- Crohn's disease (3)
- Cu(111) (3)
- Cyanobacteria (3)
- Cycloadditionen (3)
- Cycloadditions (3)
- Cystic fibrosis (3)
- Cytogenetik (3)
- Cytostatikum (3)
- DAT (3)
- DBH (3)
- DFB laser (3)
- DMD (3)
- DNA double strand breaks (3)
- DNA double-strand breaks (3)
- DNS-Schaden (3)
- DNS-Sequenz (3)
- DSG2 (3)
- DTI (3)
- DUB (3)
- DW-MRI (3)
- DWI (3)
- DYT1 (3)
- DaTscan (3)
- Data Fusion (3)
- Data Warehouse (3)
- Dauerfrostboden (3)
- Deeskalation (3)
- Definition (3)
- Deformation (3)
- Demethylierung (3)
- Deoxyribozymes (3)
- Dermatologie (3)
- Desmogleine (3)
- Detektion (3)
- Devisenmarkt (3)
- Diabetes Mellitus (3)
- Diboran(4) (3)
- Diborin (3)
- Dictyostelium (3)
- Dienstleistung (3)
- Differentialdiagnose (3)
- Differentialgeometrie (3)
- Diffusionsgewichtete Magnetresonanztomographie (3)
- Digital Religions (3)
- Diindenoperylen (3)
- Dilatation (3)
- Dimorphismus (3)
- Discounter (3)
- Dispersion (3)
- Dissertation (3)
- Distributed Control (3)
- Diversität (3)
- Docking (3)
- Doppler-Echokardiographie (3)
- Dosimetrie (3)
- Dosis-Wirkungs-Beziehung (3)
- Down syndrome (3)
- Drahtloses lokales Netz (3)
- Dreiecksgitter (3)
- Druckmessung (3)
- Drug resistance (3)
- Duchenne muscular dystrophy (3)
- Duchenne-Syndrom (3)
- Durchflußzytometrie (3)
- Durchstrahlungselektronenmikroskopie (3)
- Dynamisches System (3)
- Düne (3)
- Dünndarmtransplantation (3)
- Dünnschichttransistor (3)
- E-cadherin (3)
- ECMO (3)
- EDA (3)
- ELBWI (3)
- EMT (3)
- EPC (3)
- EPR spectroscopy (3)
- ESS (3)
- Echtzeitsystem (3)
- Ecosystem services (3)
- Effektivität (3)
- Efficiency (3)
- Egypt (3)
- Ehescheidung (3)
- Eiablage (3)
- Eigenwert (3)
- Einfluss (3)
- Einflussfaktoren (3)
- Einkommensverteilung (3)
- Einsilbiges Wort (3)
- Einstellung (3)
- Einzelhandelsbetrieb (3)
- Einzelhandelsentwicklung (3)
- Einzelmolekülspektroskopie (3)
- Einzelzellanalyse (3)
- Eisenmangel (3)
- Elastizität (3)
- Elastizitätsmodul (3)
- Electroencephalographie (3)
- Electron Microscopy (3)
- Electropermeabilization (3)
- Electrophysiology (3)
- Elektrochromie (3)
- Elektrofusion (3)
- Elektron-Phonon-Wechselwirkung (3)
- Elektronenspinresonanzspektroskopie (3)
- Elektronensprayionisations-Massenspektrometrie (3)
- Elektronische Eigenschaft (3)
- Elektrorheologie (3)
- Ellenbogen (3)
- Eltern (3)
- Embodiment (3)
- Emerin (3)
- Emotionsverarbeitung (3)
- Empfängnisverhütung (3)
- Empowerment (3)
- Encephalomyelitis (3)
- Endobrachyösophagus (3)
- Endokrinologie (3)
- Endotheliale Dysfunktion (3)
- Energieeffizienz (3)
- Energy Efficiency (3)
- Energy Transfer (3)
- Enoyl-acyl-carrier-protein-Reductase <Enoyl-[acyl-carrier-protein]-Reductase> (3)
- Entgeltumwandlung (3)
- Entmarkung (3)
- Entnahmemorbidität (3)
- Entscheidungsfindung (3)
- Environment (3)
- Enzephalitis (3)
- Enzyme (3)
- Enzyme induction (3)
- Enzyme-linked immunosorbent assay (3)
- Enzymes (3)
- Enzymkinetik (3)
- Epac (3)
- Ephedrin (3)
- Epichloë (3)
- Epidermaler Wachstumsfaktor (3)
- Epidermis (3)
- Ereignisdatenanalyse (3)
- Ergospirometrie (3)
- Erregbarkeit (3)
- Erreger (3)
- Erste Hilfe (3)
- Ertaubung (3)
- Erwachsene (3)
- Erweiterte Realität <Informatik> (3)
- Erythrozyt (3)
- Erzähltechnik (3)
- Erzählung (3)
- Escitalopram (3)
- Essstörungen (3)
- Estrogene (3)
- Etomidat (3)
- European beech (3)
- Europäische Ethnologie (3)
- Event (3)
- Event-related potential (3)
- Events (3)
- Evoziertes Potenzial (3)
- Exciton (3)
- Exekutive Funktionen (3)
- Expansion microscopy (3)
- Experimentelle autoimmune Enzephalomyelitis (3)
- Extrazellulärraum (3)
- Exzitonenkopplung (3)
- FAEP (3)
- FAP (3)
- FIR-Spektroskopie (3)
- FRAP (3)
- FSME (3)
- FT-IR-Spektroskopie (3)
- FTY720 (3)
- FabI (3)
- Fabry-associated pain (3)
- Fahrerassistenz (3)
- Faktorenanalyse (3)
- Fallstudie (3)
- Fanconi Anaemia (3)
- Femtochemie (3)
- Femtosekunden (3)
- Femtosekundenlaser (3)
- Fernröntgenseitenbild (3)
- Ferrocen (3)
- Ferromagnetic Semiconductors (3)
- Ferromagnetische Schicht (3)
- Fettsäurebiosynthese (3)
- Fettsäuren (3)
- Fibrin (3)
- Fibromyalgia syndrome (3)
- Fibronektin (3)
- Fingolimod (3)
- Finite Elemente (3)
- Finite-Volumen-Methode (3)
- Fisch (3)
- Fische (3)
- Flavour <Elementarteilchen> (3)
- Flavourmischung (3)
- Fließfähigkeit (3)
- Flora (3)
- Fluid (3)
- Fluor-19 (3)
- Fluorescence spectroscopy (3)
- Fluoxetin (3)
- Fluss (3)
- Fokker-Planck-Gleichung (3)
- Foldamers (3)
- Follow-up (3)
- Forecasting (3)
- Formulierung (3)
- Formulierungsentwicklung (3)
- Fossile Muscheln (3)
- Fotochemie (3)
- FoxP3 (3)
- Fragmentbefestigung (3)
- Frailty (3)
- Franconia (3)
- Frauenarbeit (3)
- Freiburger Sprachverständnistest (3)
- Freie-Elektronen-Laser (3)
- Fremdsprache (3)
- Frequenzvervielfachung (3)
- Fries (3)
- Frosch (3)
- Frühgeborenes (3)
- Frühgeburt (3)
- Frühneuhochdeutsch (3)
- Fulleren (3)
- Fundusautofluoreszenz (3)
- Fusarium (3)
- Fusion (3)
- G-Protein (3)
- G-Proteine (3)
- G-protein-coupled receptors (3)
- GABAA receptors (3)
- GAS2L3 (3)
- GDF-15 (3)
- GDF-5 (3)
- GFP (3)
- GLUT3 (3)
- GM-CSF (3)
- GMP (3)
- Galectine (3)
- Galerkin-Methode (3)
- Gamma-Burst (3)
- Ganztagsschule (3)
- Gasgemisch (3)
- Gasphase (3)
- Gastric-banding (3)
- Gastrointestinaler Tumor (3)
- Gauge-gravity correspondence (3)
- Gaussian approximation (3)
- Gebrechlichkeit (3)
- Gebärmutterhalskrebs (3)
- Gefahr (3)
- Gefäßpflanzen (3)
- Gelernte Hilflosigkeit (3)
- Gemcitabin (3)
- Gen-Knockout (3)
- Gender Studies (3)
- Gene therapy (3)
- Genome (3)
- Genomics (3)
- Genotyp (3)
- Gentamicin (3)
- Geoarchäologie (3)
- Geografie (3)
- Geomorphogenese (3)
- Geomorphology (3)
- Gerechtigkeit (3)
- Gerinnungsfaktor XII (3)
- German (3)
- Germanen (3)
- Geschichte 1800-1900 (3)
- Geschlechtschromosomen (3)
- Geschmack (3)
- Gesellschaften ohne Zentralgewalt (3)
- Gestationsdiabetes (3)
- Gesundheitssystem (3)
- Gesundheitsverhalten (3)
- Gewebekleber (3)
- Gewebemodell (3)
- Gibbs free energy of binding (3)
- Gingivitis (3)
- Gitterbaufehler (3)
- Glaskeramik (3)
- Gletscher (3)
- Glia (3)
- Glioblastoma multiforme (3)
- Glucocorticoide (3)
- Glucosetransport (3)
- Glucosinolate (3)
- Glukose (3)
- Glutamat (3)
- Glutamat-Decarboxylase (3)
- Glutathione (3)
- Glycin (3)
- Golgi (3)
- Grad-seq (3)
- Grading (3)
- Graft-versus-host disease (3)
- Griechenland (3)
- Griechisch (3)
- Grimmelshausen (3)
- Grippe (3)
- Grundfrequenz (3)
- Grundwasser (3)
- Grundwasserbildung (3)
- Guillain-Barré syndrome (3)
- HFOV (3)
- HFrEF (3)
- HHV-6 (3)
- HSM (3)
- Hadron Colliders (3)
- Halogene (3)
- Hamburg (3)
- Hand (3)
- Handschrift (3)
- Haplotypanalyse (3)
- Harmonic Imaging (3)
- Harnableitung (3)
- Harninkontinenz (3)
- Harnwegsinfektionen (3)
- Hauptgruppenelementverbindungen (3)
- Hausarzt (3)
- Hautflügler (3)
- Hautmodell (3)
- Hearing loss (3)
- Hefeartige Pilze (3)
- Helferzelle (3)
- Heliosphäre (3)
- Hepatotoxizität (3)
- Herbivory (3)
- Hereditäres Angioödem (3)
- Hermeneutik (3)
- Herrschaft (3)
- Herz-Lungen-Maschine (3)
- Herzoperation (3)
- Herzrhythmusstörung (3)
- Herzstoffwechsel (3)
- Herztransplantation (3)
- Heteroepitaxie (3)
- Heterostruktur-Bauelement (3)
- Hexacoordination (3)
- Hexakoordination (3)
- Hey (3)
- Hill numbers (3)
- Hip (3)
- Hirnendothelzellen (3)
- Hirnforschung (3)
- Hirnhautentzündung (3)
- Hirninfarkt (3)
- Hirnmetastase (3)
- Hirnmetastasen (3)
- Hirnstimulation (3)
- Hirschsprung disease (3)
- Histon-Deacetylase (3)
- Historische Aufnahme (3)
- Hitzeschockprotein (3)
- Hitzeschockproteine (3)
- Hitzeschocktranskriptionsfaktor (3)
- Hochdosischemotherapie (3)
- Hochschullehrende (3)
- Hochschulschrift (3)
- Hodgkin lymphoma (3)
- Hofkomponist (3)
- Holozän (3)
- Homerus (3)
- Human-Computer Interaction (3)
- Humans (3)
- Hummel (3)
- Hummeln (3)
- Hydroborierung (3)
- Hydroxyethylstärke (3)
- Hyperalgesie (3)
- Hyperekplexie (3)
- Hyperglykämie (3)
- Hypernephrom (3)
- Hyperthermie (3)
- Hämodiafiltration (3)
- Härte (3)
- Höranstrengung (3)
- Hörprüfung (3)
- Hüftprothese (3)
- Hüfttotalendoprothese (3)
- ICU (3)
- IGF-1 (3)
- IGF-I (3)
- IGRT (3)
- IL-12 (3)
- IL-1β (3)
- IS256 (3)
- ISS (3)
- IT-Sicherheit (3)
- IVF (3)
- Identität (3)
- Identitätsentwicklung (3)
- Ideomotorik (3)
- IgE (3)
- IgG (3)
- IgM (3)
- Iminoborane (3)
- Immundefekt (3)
- Immunglobulin (3)
- Immunglobulin M (3)
- Immunoseneszenz (3)
- Immunosuppression (3)
- Impedanzspektroskopie (3)
- Impfstatus (3)
- Implantate (3)
- Implantation (3)
- In-vitro (3)
- Index (3)
- Indiumarsenid (3)
- Indiumphosphid (3)
- Individuationsprozess (3)
- Industrie 4.0 (3)
- Infarkt (3)
- Inflation Targeting (3)
- Information (3)
- Information Extraction (3)
- Information Retrieval (3)
- Inhaltsanalyse (3)
- Inhibitorische Synapse (3)
- Initiation (3)
- Inklusion <Soziologie> (3)
- Inklusiver Unterricht (3)
- Innere Uhr (3)
- Insects (3)
- Insulinresistenz (3)
- Intensivmedizin (3)
- Intensivtransport (3)
- Interleukin (3)
- Interleukin 5 (3)
- Interleukin-1 (3)
- Interleukin-5 (3)
- Interleukin-6 (3)
- Intermedialität (3)
- Internationale Politik (3)
- Internationales Gesellschaftsrecht (3)
- Intervention (3)
- Interventionsradiologie (3)
- Intraokularer Druck (3)
- Intrazellulärraum (3)
- Inzidentalom (3)
- Inzidenz (3)
- Inzidenz <Medizin> (3)
- Iod (3)
- Ionische Flüssigkeiten (3)
- Irradiation (3)
- Ischemia (3)
- Ischemic stroke (3)
- Ischämischer Schlaganfall (3)
- Isolierung (3)
- Isomer (3)
- Italien (3)
- Italienisch (3)
- J- and H-Aggregate (3)
- J- and H-Aggregates (3)
- Jurassic (3)
- Kafka (3)
- Kaiserschnitt (3)
- Kalzium (3)
- Kaninchen (3)
- Kannenpflanze (3)
- Kanzerogenese (3)
- Kardiomyozyt (3)
- Kardiomyozyten (3)
- Kardioprotektion (3)
- Kardiovaskuläre Krankheit (3)
- Karyotyp (3)
- Karzinom (3)
- Karzinomzellen (3)
- Katarakt (3)
- Katatonie (3)
- Katecholamine (3)
- Kausalmodell (3)
- Kehlkopf (3)
- Kenyon cells (3)
- Keramikfaser (3)
- Kernspinrelaxation (3)
- Ketogene Kost (3)
- Ketonkörper (3)
- Ki-67 (3)
- Ki67 (3)
- Kiefer- und Gesichtschirurgie (3)
- Kiefernrindenextrakt (3)
- Kinderchirurgie (3)
- Kleinkinderziehung (3)
- Klimamodell (3)
- Klimaschutz (3)
- Klinische Psychotherapie (3)
- Klinische Studie (3)
- Klonalität (3)
- Knee (3)
- Kniegelenkarthrose (3)
- Knochenmarktransplantation (3)
- Knochennekrose (3)
- Knochenstoffwechsel (3)
- Knochentumor (3)
- Knockdown (3)
- Knockout-Maus (3)
- Knorpelintegration (3)
- Koffein (3)
- Kognitive Psychologie (3)
- Kognitive Verhaltenstherapie (3)
- Kognitiver Prozess (3)
- Kohlendioxid (3)
- Kokultur (3)
- Kolon (3)
- Kolonialismus (3)
- Komfortlaut (3)
- Kommune (3)
- Kommunikationstraining (3)
- Komplexes regionales Schmerzsyndrom (3)
- Kompressionstherapie (3)
- Komprimierte Abtastung (3)
- Kondensation (3)
- Kondo-Modell (3)
- Kondo-System (3)
- Konfidenzintervall (3)
- Konjugate (3)
- Konjugation (3)
- Kontamination (3)
- Kontinenz (3)
- Kontrolle (3)
- Kontrolltheorie (3)
- Konvergenz (3)
- Konversationsanalyse (3)
- Kopforthesentherapie (3)
- Korbblütler (3)
- Koronarchirurgie (3)
- Koronarperfusion (3)
- Korpuslinguistik (3)
- Korrektur (3)
- Korrelative Mikroskopie (3)
- Kosmische Strahlung (3)
- Kraftmessung (3)
- Kraniopharyngeom (3)
- Kraniopharyngiom (3)
- Krankenhaus (3)
- Krankheitsverlauf (3)
- Kreatinkinase (3)
- Kreditmarkt (3)
- Krieg (3)
- Kristallographie (3)
- Kulturkontakt (3)
- Kulturtheorie (3)
- Kunst (3)
- Kurfürst (3)
- Kurzzeitphysik (3)
- Körper (3)
- Körperwahrnehmung (3)
- L929 (3)
- LAD (3)
- LC-HRESIMS (3)
- LIF (3)
- LNCaP (3)
- LTD (3)
- Lactatdehydrogenase (3)
- Laminopathie (3)
- Landschaft (3)
- Landschaftsentwicklung (3)
- Landshuter Gesangbuch (3)
- Langzeitdepression (3)
- Langzeitprognose (3)
- Larve (3)
- Laryngeale Konstriktion (3)
- Larynx (3)
- Larynxkarzinom (3)
- Laserchemie (3)
- Laserdiode (3)
- Laserstrahlung (3)
- Late Enhancement (3)
- Learning and memory (3)
- Lebendgebärende Zahnkarpfen (3)
- Lebensdauer (3)
- Lebensmitteleinzelhandel (3)
- Lebermetastase (3)
- Legasthenie (3)
- Legionellen (3)
- Lehr-Lern-Labor (3)
- Lehramtsstudium (3)
- Lehrerhandreichung (3)
- Lehrkräftebildung (3)
- Leistenhernie (3)
- Lepra (3)
- Lepton (3)
- Lernstrategien (3)
- Lerntechnik (3)
- Letalität (3)
- Leukoplakie (3)
- Lewis acid (3)
- Lewis-Addukt (3)
- Lexikographie (3)
- Licht (3)
- Lichtstreuung (3)
- Lidschlag (3)
- Ligamentum cruciatum anterius (3)
- Linear Pottery (3)
- Linienbreite (3)
- Lipidmembran (3)
- Lipidstoffwechsel (3)
- Lipopolysaccharid (3)
- Lipopolysaccharide (3)
- Lipoprotein (3)
- Lipoxygenase (3)
- Lipoxygenase <5-> (3)
- Literaturunterricht (3)
- Ljapunov-Funktion (3)
- LoRaWAN (3)
- Lolium perenne (3)
- Luminescence (3)
- Lungenentzündung (3)
- Lungenmetastase (3)
- Lungenperfusionsmodell (3)
- Lungentumor (3)
- Lurche (3)
- Luttinger-Flüssigkeit (3)
- Lycopersicon esculentum (3)
- Lyme-Krankheit (3)
- Lymphocytes (3)
- Lymphoma (3)
- Lysosomale Speicherkrankheit (3)
- Lysozym (3)
- Ländlicher Raum (3)
- Längsschnittstudie (3)
- MALT-Lymphom (3)
- MALT1 (3)
- MAP kinase (3)
- MC simulation (3)
- MDD (3)
- MDR (3)
- MDSC (3)
- MEK (3)
- MGMT (3)
- MHC Klasse II (3)
- MLC1 (3)
- MLST (3)
- MMN (3)
- MMP-9 (3)
- MOF (3)
- MOFs (3)
- MPI (3)
- MSCT (3)
- MSSM (3)
- Magma (3)
- Magnesiumphosphat (3)
- Magnetic Anisotropy (3)
- Magnetische Eigenschaft (3)
- Magnetischer Röntgenzirkulardichroismus (3)
- Magnetoelastizität (3)
- Magnetresonanz (3)
- Magnetresonanztomografie (3)
- Makrocyclische Verbindungen (3)
- Malariamücke (3)
- Malaysia (3)
- Malignant Hyperthermia (3)
- Malignant hyperthermia (3)
- Malignant melanoma (3)
- Malnutrition (3)
- Mamma (3)
- Manganate (3)
- Manganselenide (3)
- Mangansilicide (3)
- Mannheim (3)
- Mantelzell-Lymphom (3)
- Mantle cell lymphoma (3)
- Mapping (3)
- Marker (3)
- Markteintrittsstrategie (3)
- Mastdarmkrebs (3)
- Materielle Kultur (3)
- Matrixmetalloproteinasen (3)
- Maximilian <Bayern> (3)
- Mc4r (3)
- Measurement (3)
- Measuring Masses (3)
- Mechanische Eigenschaft (3)
- Mechanorezeptor (3)
- Mechanotransduktion (3)
- Medien-/Kulturwissenschaft (3)
- Medienanalyse (3)
- Medienkonsum (3)
- Medizinische Rehabilitation (3)
- Medizinstudent (3)
- Medizinstudium (3)
- Megakaryocyte (3)
- Megakaryopoese (3)
- Mehrschichtsystem (3)
- Melatonin (3)
- Melt Electrowriting (3)
- Melt electrowriting (3)
- Memantin (3)
- Membranpotential (3)
- Membranrezeptor (3)
- Memristor (3)
- Meniskus (3)
- Merkel cell polyomavirus (3)
- Merkel-Zellkarzinom (3)
- Merocyanin (3)
- Mesenchymal Stem Cells (3)
- Mesenchymale Stromazellen (3)
- Mesophyll (3)
- Mesoskopisches System (3)
- Metall-Isolator-Phasenumwandlung (3)
- Metallcarbonyle (3)
- Metalloarenophane (3)
- Metalloberfläche (3)
- Metalloprotease (3)
- Metallorganische Chemie (3)
- Metapher (3)
- Metastasierung (3)
- Methodenentwicklung (3)
- Methohexital (3)
- Methotrexate (3)
- Methyltransferase (3)
- Metoprolol (3)
- Microdialyse (3)
- Migrationshintergrund (3)
- Mikrokavität (3)
- Mikroklima (3)
- Mikrooptik (3)
- Mikroporosität (3)
- Mikrosatelliten (3)
- Mikrotubuli (3)
- Mikroverkapselung (3)
- Mineralisation (3)
- Mineralokortikoidrezeptor (3)
- Mip (3)
- Mismatch (3)
- Mittelhochdeutsch (3)
- Mittelmeerraum (3)
- Modifizierung (3)
- Molecular Beam Epitaxy (3)
- Molecular biology (3)
- Molecular dynamics (3)
- Monoaminoxidase (3)
- Monodromie (3)
- Monte Carlo simulation (3)
- Morphogenese (3)
- Mosaik (3)
- Motorische Entwicklung (3)
- Mott-Übergang (3)
- Mouse model (3)
- Mucorales (3)
- Multiagentensystem (3)
- Multimedia (3)
- Multiple bonds (3)
- Multispecies Studies (3)
- Mundart (3)
- Mundhöhle (3)
- Mundhöhlenkrebs (3)
- Mundhöhlentumor (3)
- Muscarin (3)
- Muscarinic receptor subtypes (3)
- Muscarinic receptors (3)
- Museumspädagogik (3)
- Musikwahrnehmung (3)
- Muskelkraft (3)
- Muster (3)
- Mutante (3)
- Mutationsrate (3)
- Mycobacterium (3)
- Myelin oligodendrocyte glycoprotein antibodies (MOG-IgG) (3)
- Myeloma (3)
- Mythos (3)
- Mädchenfußball (3)
- Münchner Hof (3)
- N-Heterocyclic Carbenes (3)
- N-heterocyclic carbene (3)
- N170 (3)
- NADPH-Oxidase (3)
- NIR (3)
- NK cell (3)
- NK-Zellen (3)
- NLS (3)
- NMR-spectroscopy (3)
- NOS1AP (3)
- NSG (3)
- NVP-BEZ235 (3)
- Nabelhernie (3)
- Nachruf (3)
- Nahtmaterial (3)
- Nanoelektronik (3)
- Nanomaterialien (3)
- Naphthalinderivate (3)
- Naphthylisochinoline (3)
- Narrative (3)
- Narratologie (3)
- Natalizumab (3)
- Nationalpark (3)
- Natrium (3)
- Natrium-Calcium-Austauscher (3)
- NaturenKulturen (3)
- Nebennierenkrise (3)
- Nepenthes (3)
- Nervenstimulation (3)
- Nervensystem (3)
- Nestin (3)
- Networks (3)
- Netzwerkmanagement (3)
- Neumarkt <Oberpfalz> (3)
- Neuroblast (3)
- Neuroendokrines System (3)
- Neuromyelitis optica spectrum disorders (NMOSD) (3)
- Neuronale Netze (3)
- Neuropeptid Y (3)
- Neuroprotection (3)
- Neuropsychologie (3)
- Neuroscience (3)
- Neurotizismus (3)
- Neurotransmitter (3)
- Neurotrophe Faktoren (3)
- Neurotrophine (3)
- Neutrophil (3)
- Neutrophils (3)
- New Zealand (3)
- Nichtadiabatischer Prozess (3)
- Nichtionisierende Strahlung (3)
- Nichtkonvexe Optimierung (3)
- Nichtlineares System (3)
- Nicotin (3)
- Nicotine (3)
- Nicotinischer Acetylcholinrezeptor (3)
- Niederdimensionales Elektronengas (3)
- Niederdimensionales System (3)
- Nierenkrebs (3)
- Nitric oxide (3)
- Nociceptor (3)
- Noradrenalin (3)
- Norm (3)
- Nozizeption (3)
- Nozizeptor (3)
- Nrf2 (3)
- Nucleolus (3)
- Nude-mice (3)
- Numerische Strömungssimulation (3)
- ODMR-Spektroskopie (3)
- OSAS (3)
- OST1 (3)
- Oberflächenplasmonresonanz (3)
- Octopamin (3)
- Octopamine (3)
- Olfaktion (3)
- Olfaktorik (3)
- Oligonucleotide (3)
- Omega-3-Fettsäuren (3)
- Omp85 (3)
- Oogenese (3)
- Open Access (3)
- Operante Konditionierung (3)
- Optic neuritis (3)
- Optical Spectroscopy (3)
- Optische Eigenschaft (3)
- Optische Zeichenerkennung (3)
- Organic Semiconductors (3)
- Organisationskultur (3)
- Organische Halbleiter (3)
- Orient (3)
- Orientalistik (3)
- Oropharynx (3)
- Osmolarität (3)
- Osseointegration (3)
- Osteoarthrose (3)
- Osteoblast (3)
- Osteoklast (3)
- Osteoporosis (3)
- Outcome survey (3)
- OxLDL (3)
- Oxygen (3)
- P-glycoprotein (3)
- PDGF (3)
- PDZ-Domain (3)
- PDZ-Domäne (3)
- PFC (3)
- PKB (3)
- PKC (3)
- PLC (3)
- PMCA (3)
- PNP (3)
- PROM (3)
- PTSD (3)
- PZT (3)
- Paclitaxel (3)
- Pair Production (3)
- Pakistan (3)
- Palliative Care (3)
- Palliativversorgung (3)
- Pappel (3)
- Paracyclophane (3)
- Paraffin (3)
- Parallel Imaging (3)
- Pareto-Verteilung (3)
- Parkinson Disease (3)
- Parkinsons disease (3)
- Particle Physics (3)
- Particle data analysis (3)
- Passionsspiel (3)
- Passivrauchen (3)
- Patella (3)
- Patellaluxation (3)
- Pathogener Mikroorganismus (3)
- Pathogenitätsinseln (3)
- Pathology (3)
- Pathophysiologie (3)
- Patient education (3)
- Patterns (3)
- Peer-to-Peer-Netz (3)
- Pentacoordination (3)
- Peristaltik (3)
- Peritonitis (3)
- Permafrost (3)
- Peroxisom (3)
- Persönlichkeitsmerkmale (3)
- Persönlichkeitsstörung (3)
- Perylen (3)
- Pest (3)
- Peyer's patch (3)
- Phagosom (3)
- Pharmaceutical Analysis (3)
- Pharmazeutischer Hilfsstoff (3)
- Phonologie (3)
- Phosphate (3)
- Phosphorylation (3)
- Photoinduzierter Elektronentransfer (3)
- Photoluminescence (3)
- Photolyse (3)
- Photolysis (3)
- Photonische Kristalle (3)
- Photonischer Kristall (3)
- Photopolymerisation (3)
- Photosensibilisator (3)
- Physical activity (3)
- Physik jenseits des Standardmodells (3)
- Physikunterricht (3)
- Physiologische Psychologie (3)
- Phytohormone (3)
- Piperidinalkaloide (3)
- Plaque (3)
- Plasmodium (3)
- Plastik (3)
- Plattform (3)
- Platy (3)
- Pleuraerguss (3)
- Plexus brachialis (3)
- Pluripotenz (3)
- Plättchen (3)
- Pneumolysin (3)
- Poetik (3)
- Poetologie (3)
- Polycomb (3)
- Polycyclic Aromatic Hydrocarbons (3)
- Polyglycidol (3)
- Polymerase chain reaction (3)
- Polymers (3)
- Polymorphismen (3)
- Polyomaviren (3)
- Populationsgenetik (3)
- Poribacteria (3)
- Porphyrin (3)
- Porphyrine (3)
- Poröser Stoff (3)
- Positron Emission Tomography (3)
- Positron emission tomography (3)
- Postmoderne (3)
- Posttranslationale Änderung (3)
- Predictors (3)
- Pregnancy (3)
- Preisbindung (3)
- Prionprotein (3)
- Procyanidine (3)
- Prognosefaktor (3)
- Prognosefaktoren (3)
- Promoter (3)
- Prophylaxe (3)
- Prostate Cancer (3)
- Prostatektomie (3)
- Protection (3)
- Protein p8 (3)
- Protein-Serin-Threonin-Kinasen (3)
- Proteinkinase CK2 (3)
- Proteinkinase D (3)
- Proteintransport (3)
- Proteinurie (3)
- Proteomics (3)
- Proton-Proton Collisions (3)
- Protonenpumpe (3)
- Protozoen (3)
- Präfrontaler Kortex (3)
- Prüfungshonorare (3)
- Prüfungsqualität (3)
- Pseudarthrose (3)
- Pseudomonas aeruginosa (3)
- Psychology (3)
- Psychoneuroimmunologie (3)
- Psychopathologie (3)
- Psychophysik (3)
- Psychotherapeutischer Prozess (3)
- Psychotherapy (3)
- Pulswelle (3)
- Pycnogenol (3)
- Pyrene (3)
- QCD (3)
- QST (3)
- Quadrotor (3)
- Quantenelektrodynamik (3)
- Quantitative Analyse (3)
- Quantum Information (3)
- Quantum Monte Carlo (3)
- Quantum dots (3)
- Quantum dynamics (3)
- Quantum many-body systems (3)
- Quartär (3)
- Quercetin (3)
- R package (3)
- RHO (3)
- RIM101 (3)
- RKIP (3)
- RNA metabolism (3)
- RNA splicing (3)
- RNA structure (3)
- RNA-SEQ (3)
- RNA-sequencing (3)
- RNAseq (3)
- RNS-Viren (3)
- RPE (3)
- RSK2 (3)
- RT-qPCR (3)
- Rac (3)
- Radarsat-2 (3)
- Radiation (3)
- Radikal (3)
- Radiochemotherapie (3)
- Radiologie (3)
- Radiosurgery (3)
- Radius (3)
- Raman Spektroskopie (3)
- Ranunculus auricomus (3)
- Rassismus (3)
- Rastertunnelspektroskopie (3)
- Rating (3)
- Rats (3)
- Raucher (3)
- Raumfahrt (3)
- Raumverhalten (3)
- Rauschen (3)
- Real-time PCR (3)
- Reanimation (3)
- Rechnungswesen (3)
- Rechtschreibschwäche (3)
- Recovery (3)
- Recurrence (3)
- Recurrensparese (3)
- Reduction (3)
- Reform (3)
- Reformpädagogik (3)
- Regionalanästhesie (3)
- Regionalwirtschaft (3)
- Regularisierung (3)
- Relapse (3)
- Relaxometry (3)
- Religious Education (3)
- Religiöse Bildung (3)
- Remifentanil (3)
- Remineralisation (3)
- Remission (3)
- Renaissance (3)
- Renal cell carcinoma (3)
- Renin-Angiotensin-Aldosteron-System (3)
- Replikationsursprung (3)
- Repression <Genetik> (3)
- Reproduktion (3)
- Resistance (3)
- Resonanz (3)
- Resonanz-Raman-Effekt (3)
- Resonanz-Tunneldiode (3)
- Resonanz-Tunneleffekt (3)
- Ressourcenallokation (3)
- Restenose (3)
- Retinoic acid (3)
- Retinsäure (3)
- Rezeptortyrosinkinase (3)
- Rezidivrate (3)
- Rho (3)
- Rho GTPase (3)
- Rhodiumkomplexe (3)
- Riester-Rente (3)
- Ringspannung (3)
- Risikomanagement (3)
- Risk Assessment (3)
- Risk factors (3)
- Ritual (3)
- Rossameise (3)
- Rubus (3)
- Ruthenium Komplexe (3)
- Räumliche Verteilung (3)
- Römisches Reich (3)
- Röntgenabsorptionsspektroskopie (3)
- Röntgenastronomie (3)
- Röntgenkristallographie (3)
- Röntgenmikroskopie (3)
- Röntgenstrukturanalyse (3)
- SBRT (3)
- SEM (3)
- SF-36 (3)
- SGLT (3)
- SIRS (3)
- SIV (3)
- SLAM (3)
- SLOOP (3)
- SM background (3)
- SMARD1 (3)
- SOCE (3)
- SPECT/CT (3)
- SRT (3)
- STAT (3)
- STAT6 (3)
- STIM2 (3)
- STM (3)
- STR (3)
- SWOT (3)
- Salmonella typhi (3)
- Salz (3)
- Samenpflanzen (3)
- Sammeln (3)
- Sarkopenie (3)
- Satellitenfernerkundung (3)
- Satzglied (3)
- Scarabaeidae (3)
- Scattering (3)
- Scheibe-Aggregat (3)
- Scherfestigkeit (3)
- Scherstress (3)
- Schichttechnik (3)
- Schilddrüsenkarzinom (3)
- Schleimhaut (3)
- Schleswig-Holstein (3)
- Schließzellen (3)
- Schockraumalgorithmus (3)
- Schreckreaktion (3)
- Schreimelodie (3)
- Schuppenflechte (3)
- Schwann cells (3)
- Schwingungsspektroskopie (3)
- Search (3)
- Secretion (3)
- Sectio caesarea (3)
- Sedimentologie (3)
- Segmentierung (3)
- Sekundarstufe 1 (3)
- Selbstgesteuertes Lernen (3)
- Selbstmord (3)
- Selenoprotein P (3)
- Self-Assembly (3)
- Semantik (3)
- Semiconductors (3)
- Seneca (3)
- Senescence (3)
- Seneszenz (3)
- Sensors (3)
- Sequenzierung (3)
- Serotonin-Reuptake-Hemmer (3)
- Serotonintransporter (3)
- Service Learning (3)
- Sexualität (3)
- Shigella (3)
- Shigella flexneri (3)
- Sicherheit (3)
- Sicherheitspolitik (3)
- Siedlungsarchäologie (3)
- Signaltransduction (3)
- Silanderivate (3)
- Siloran (3)
- Simulationstraining (3)
- Singlet Oxygen (3)
- Singulettsauerstoff (3)
- Sinnesphysiologie (3)
- Situationsbewusstsein (3)
- Skalierbarkeit (3)
- Skiverletzung (3)
- Skorpion (3)
- Social Cognition (3)
- Social interaction (3)
- Socrates (3)
- Software-defined networking (3)
- Softwarearchitektur (3)
- Solubilisation (3)
- Sonnenwind (3)
- Sozialangst (3)
- Sozialgeschichte (3)
- Sozialisation (3)
- Sozialität (3)
- Soziologie des Dritten (3)
- Species richness (3)
- Speckle tracking (3)
- Speiseröhre (3)
- Spektroelektrochemie (3)
- Spermatogenesis (3)
- Spezialisierung (3)
- Spieltheorie (3)
- Spin-Gitter-Relaxation (3)
- Spinal Muscular Atrophy (3)
- Spinalanästhesie (3)
- Spinalganglion (3)
- Spinchemie (3)
- Spinnenseide (3)
- Spironolacton (3)
- Spleißen (3)
- Spleißosom (3)
- Splicing (3)
- Sprachverständlichkeit (3)
- Spred Protein (3)
- Src-Proteine (3)
- Staat (3)
- Stachellose Biene (3)
- Staging (3)
- Stakeholder (3)
- Standardisierung (3)
- Staphylokokken (3)
- Stat3 (3)
- Sterbebegleitung (3)
- Stereophotogrammetrie (3)
- Stereophotogrammetry (3)
- Stereoselectivity (3)
- Sternpolymere (3)
- Steroide (3)
- Steroidhormon (3)
- Steuer (3)
- Stickstoffoxide (3)
- Stochastische Resonanz (3)
- Stochastischer Prozess (3)
- Stomata (3)
- Stoßwelle (3)
- Strafrecht (3)
- Straftat (3)
- Strafvollzug (3)
- Strahlung (3)
- Strainrate (3)
- Strandkiefer (3)
- Structural elucidation (3)
- Strukturbasiertes Wirkstoffdesign (3)
- Strömung (3)
- Suberin (3)
- Substantia nigra (3)
- Substratspezifität (3)
- Succinylcholine (3)
- Sucht (3)
- Suizidalität (3)
- Sulforaphan (3)
- Super-resolution microscopy (3)
- Superparamagnetismus (3)
- Supersymmetric models (3)
- Supply Chain (3)
- Surface modification (3)
- Surface plasmons (3)
- Switzerland (3)
- Symmetry (3)
- Synaptische Transmission (3)
- Synaptische Vesikel (3)
- Synchronisierung (3)
- Synchronization (3)
- Systemisches Risiko (3)
- Süddeutsche Zeitung (3)
- Südkorea (3)
- Südostasien (3)
- T cell development (3)
- T cell receptors (3)
- T lymphocyte (3)
- T-Zell-Rezeptor (3)
- T-Zellaktivierung (3)
- T-Zellrezeptor (3)
- T-cadherin (3)
- T-cell lymphoma (3)
- T1 (3)
- TCR (3)
- TD-DFT (3)
- TEM (3)
- TGF-ß (3)
- TGN1412 (3)
- THA (3)
- TLR3 (3)
- TLR8 (3)
- TNF superfamily (3)
- TRAF1 (3)
- TRH (3)
- TRPA1 (3)
- TTFields (3)
- Taiwan (3)
- Talentförderung (3)
- Tantal (3)
- Targeted therapy (3)
- Taxol (3)
- Teaching (3)
- Testament (3)
- Testbatterie (3)
- Testosteron (3)
- Text (3)
- Textvergleich (3)
- Therapieergebnisse (3)
- Therapieresistenz (3)
- Thermoelektrizität (3)
- Thiazolidindione (3)
- Thigmotaxis (3)
- Thioaldehyde (3)
- Thiophen (3)
- Thioredoxin (3)
- Thrombozytenaktivierung (3)
- Thrombozytopenie (3)
- Thrombus (3)
- Thyroid cancer (3)
- Tibiakopfbruch (3)
- Tibiakopfimpressionsfraktur (3)
- Tiergesellschaft (3)
- Tierversuch (3)
- Tierökologie (3)
- Titanium (3)
- Tolerance (3)
- Tomografie (3)
- Topoisomerase I (3)
- Topological Insulator (3)
- Topological insulators (3)
- Topologische Phase (3)
- Topologische Supraleitung (3)
- Topology (3)
- Tourette syndrome (3)
- Tourism (3)
- Trachea (3)
- Tragik (3)
- Transaktivierung (3)
- Transforming Growth Factor beta 1 (3)
- Transiente Absorptionsspektroskopie (3)
- Transistor (3)
- Transparent-leitendes Oxid (3)
- Transportspektroskopie (3)
- Tricalciumphosphat (3)
- Triphyophyllum peltatum (3)
- Triquinacenderivate (3)
- Trockenstress (3)
- Trypanosoma brucei brucei (3)
- Trypanosomes (3)
- Tuberculosis (3)
- Tuff (3)
- Tumor-necrosis-factor (3)
- Tumormodell (3)
- Tumorstammzellen (3)
- Tumorstoffwechsel (3)
- Tumorsuppressor-Gen (3)
- Tumortherapiefelder (3)
- Tumorwachstum (3)
- Tumorzellen (3)
- Turbulenz (3)
- Tyrosinkinaseinhibitor (3)
- UPEC (3)
- USP8 (3)
- Ubiquitin-Protein-Ligase (3)
- Ulcerative colitis (3)
- Ultrafiltration (3)
- Ultraschallkontrastmittel (3)
- Umbilikalhernie (3)
- Umweltfaktor (3)
- Umweltpolitik (3)
- Unterrichtsmethode (3)
- Ureaplasma urealyticum (3)
- Urothelkarzinom (3)
- Uzbekistan (3)
- VKORC1 (3)
- VLBWI (3)
- VMD2 (3)
- VSOP (3)
- Variant surface glycoprotein (3)
- Variants (3)
- Varianzanalyse (3)
- Variationsrechnung (3)
- Vasopressin (3)
- Vegetatives Nervensystem (3)
- Verbraucherschutz (3)
- Verbreitung (3)
- Vereinte Nationen (3)
- Vernetzung <Chemie> (3)
- Versorgung (3)
- Verstärkung (3)
- Verteilung (3)
- Vertigo (3)
- Vertrauen (3)
- Verwaltung (3)
- Verwundbarkeit (3)
- Vesikel (3)
- Viabilität (3)
- Vibrio cholerae (3)
- Video Streaming (3)
- Videolaryngoskopie (3)
- Videoübertragung (3)
- Vielfalt (3)
- Vietnam (3)
- Vif (3)
- Vigilanz (3)
- Virulenzfaktoren (3)
- Visuelles System (3)
- Visus (3)
- Viszeralchirurgie (3)
- Vitamin K (3)
- Volatile Anästhetika (3)
- Volumenregulation (3)
- Volumentomographie (3)
- Vorhofohramputation (3)
- Vorkommen (3)
- Vorlesung (3)
- Vorsprachliche Entwicklung (3)
- Vulgata (3)
- Vulkanologie (3)
- Vulneranz (3)
- W boson (3)
- WNT (3)
- Wachs (3)
- Warburg effect (3)
- Warnung (3)
- Wasserlöslichkeit (3)
- Weak (3)
- Wechselkurspolitik (3)
- Weiterbildung (3)
- Wellenleiter (3)
- Werbung (3)
- Wert (3)
- Wertigkeit (3)
- Wertschöpfungskette (3)
- Wespen (3)
- Western Cape (3)
- Weyarn / Stift (3)
- Wiederbelebung (3)
- Wilms Tumor (3)
- Wilms' tumor (3)
- Wirkstoff-Träger-System (3)
- Wirkstoffdesign (3)
- Wirtschaftsentwicklung (3)
- Wirtschaftsprüfer (3)
- Wirtschaftsprüfung (3)
- Wirtschaftswachstum (3)
- Wissenschaft (3)
- Wissenserwerb (3)
- Wissensmanagement (3)
- Working memory (3)
- Wurzelhalsgalle (3)
- Wurzelkanalbehandlung (3)
- Währungsunion (3)
- Wärmeübertragung (3)
- Würzburg / Institut für Humangenetik (3)
- Würzburg / Sonderforschungsbereich II-VI-Halbleiter (3)
- Würzburg / Universität / Lehrstuhl für Bioinformatik (3)
- Xenobiotikum (3)
- Xenophon (3)
- Xenopus oocytes (3)
- Xenotransplantation (3)
- Xylem (3)
- Y chromosome (3)
- YAP (3)
- YB-1 (3)
- Zahnersatz (3)
- Zahnprothetik (3)
- Zelloberfläche (3)
- Zentralasien (3)
- Zerfall (3)
- Zetafunktion (3)
- Zinn (3)
- Zivilgesellschaft (3)
- Zugspannung (3)
- Zweidimensionales Material (3)
- Zweiphotonenabsorption (3)
- Zwischenmolekulare Kraft (3)
- ab initio calculations (3)
- abandonment (3)
- abiotic stress (3)
- abnormalities (3)
- absolute configuration (3)
- accelerometer (3)
- acceptance (3)
- acetylcholine (3)
- acetylsalicylic acid (3)
- acquisition (3)
- acrophobia (3)
- actins (3)
- action effects (3)
- action potential (3)
- activity (3)
- acupuncture (3)
- acute graft-versus-host disease (3)
- acute lymphoblastic leukemia (3)
- acute myeloid leukaemia (3)
- acute renal failure (3)
- adaption (3)
- adaptive immune system (3)
- adaptive immunity (3)
- addiction (3)
- adduct (3)
- adenocarcinoma of the lung (3)
- adenoma (3)
- adiponectin (3)
- adipose (3)
- adipose-derived stromal cells (3)
- adjuvant (3)
- adrenal crisis (3)
- adrenocortical cancer (3)
- adult ADHD (3)
- adverse events (3)
- aerobic fitness (3)
- affinity (3)
- african trypanosomes (3)
- agalsidase alfa (3)
- agalsidase beta (3)
- age groups (3)
- agonist (3)
- agr (3)
- airway management (3)
- akutes Koronarsyndrom (3)
- aldehydes (3)
- allometric scaling (3)
- alpha (3)
- altitudinal gradients (3)
- alveolar echinococcosis (3)
- ambulant (3)
- amplicon sequencing (3)
- amyloidosis (3)
- anaemia (3)
- analysis (3)
- anandamide (3)
- anastomotic leakage (3)
- angiotensin II (3)
- animal sociality (3)
- anisotropy (3)
- annulation (3)
- ansa-Komplexe (3)
- anterior insula (3)
- anthropogenic disturbance (3)
- antibakteriell (3)
- anticoagulants (3)
- antigen presentation (3)
- antigen testing (3)
- antimikrobielle Peptide (3)
- antimony (3)
- aortic aneurysm (3)
- aortic stenosis (3)
- applied physics (3)
- approach (3)
- approximation algorithm (3)
- arabidopsis (3)
- architecture (3)
- arctic (3)
- arrhythmogenic cardiomyopathy (3)
- artemisinin (3)
- arthrography (3)
- articulation (3)
- artificial photosynthesis (3)
- aspirin (3)
- assay (3)
- assistierte Reproduktion (3)
- assistive technology (3)
- association study (3)
- asymmetry (3)
- attention deficit/hyperactivity disorder (3)
- attentional control (3)
- auditory cortex (3)
- auditory evoked potentials (3)
- autism spectrum disorder (3)
- autograft (3)
- autologous stem cell transplantation (3)
- autonomes Nervensystem (3)
- avidity (3)
- axonal transport (3)
- axons (3)
- azobenzenes (3)
- bZIP (3)
- bacillus subtilis (3)
- bacterial (3)
- bacterial infection (3)
- bacterial meningitis (3)
- bacteriophage (3)
- bark beetles (3)
- barrier (3)
- beta-D-glucan (3)
- beta-oxidation (3)
- binding protein (3)
- bioactivity (3)
- biocatalysis (3)
- bioconjugation (3)
- biogenic amines (3)
- bioinformatic (3)
- biological activity (3)
- biological pest control (3)
- biological techniques (3)
- bioluminescence imaging (3)
- biomedical engineering (3)
- biomedical materials (3)
- biosensor (3)
- biosensors (3)
- biotechnology (3)
- biotransformation (3)
- birth cohort (3)
- black holes (3)
- blended learning (3)
- blood coagulation (3)
- blood vessel (3)
- body ownership (3)
- bonding agent (3)
- bone defect (3)
- bone density (3)
- bone disease (3)
- bone metabolism (3)
- bone morphogenetic protein (3)
- bone morphogenetic proteins (3)
- bone-marrow (3)
- boroles (3)
- boronate (3)
- brain cancer (3)
- brain derived neurotrophic factor (3)
- breast-tumors (3)
- bruxism (3)
- bullous pemphigoid (3)
- bumblebees (3)
- burn severity (3)
- butterflies (3)
- c-Fos (3)
- c-Myc (3)
- c-myc (3)
- cFLIP (3)
- calcification (3)
- calcium signaling (3)
- calorimetry (3)
- calpain (3)
- cancer cells (3)
- cancer microenvironment (3)
- candida (3)
- canine (3)
- canine cancer therapy (3)
- canola (3)
- capecitabine (3)
- carabid beetles (3)
- carbene ligands (3)
- carbon nanotubes (3)
- carcinogenesis (3)
- carcinogenicity (3)
- carcinoma cells (3)
- cardiac MRI (3)
- cardiac imaging (3)
- cardiac rehabilitation (3)
- cardiolipin (3)
- cardiology (3)
- cardiovascular magnetic resonance (3)
- caspase-3 (3)
- caspases (3)
- cathepsin (3)
- cationic species (3)
- cations (3)
- causality (3)
- cell binding (3)
- cell fusion (3)
- cell growth (3)
- cell imaging (3)
- cell labeling (3)
- cell signalling (3)
- cell therapy (3)
- central-nervous-system (3)
- ceramics (3)
- cerebEND (3)
- cerebellar tDCS (3)
- cerebrovascular disorders (3)
- cestode (3)
- chalcogens (3)
- channel (3)
- channelrhodopsin (3)
- chaperone (3)
- chaperones (3)
- charge separation (3)
- charged aerosol detector (3)
- chemische Kommunikation (3)
- chimeric antigen receptor (3)
- chlamydia infection (3)
- cholesterol (3)
- chromophore (3)
- chronic stress (3)
- chronophin (3)
- citrus (3)
- claudin-1 (3)
- clinical genetics (3)
- clinical outcome (3)
- clinical practice (3)
- clonality (3)
- closed head injury (3)
- cluster (3)
- coating (3)
- coatings (3)
- cochlear implantation (3)
- coexistence (3)
- cohort studies (3)
- cohort study (3)
- colonoscopy (3)
- community (3)
- community ecology (3)
- complexation (3)
- compliance (3)
- composite (3)
- conditioned response (3)
- confocal microscopy (3)
- conjugation (3)
- consolidation (3)
- contrast (3)
- contrast media (3)
- control (3)
- conversion (3)
- coordination polymer (3)
- coordination polymers (3)
- coreceptor (3)
- cornea (3)
- coronary artery bypass grafting (3)
- corticosteroids (3)
- count time series (3)
- criteria (3)
- critically ill (3)
- crossing minimization (3)
- crowdsourcing (3)
- cryptochrome (3)
- curriculum (3)
- curved hydrocarbons (3)
- cycloid psychosis (3)
- cyclophanes (3)
- cytogenetics (3)
- cytosol (3)
- data acquisition (3)
- data analysis (3)
- data fusion (3)
- data mining (3)
- death (3)
- decomposition (3)
- defects (3)
- deficient mice (3)
- deformation (3)
- deformation quantization (3)
- deletion (3)
- density (3)
- deoxyribozymes (3)
- depressive disorder (3)
- derivation (3)
- derivatives (3)
- desmin (3)
- detection (3)
- developmental differentiation (3)
- diabetic cardiomyopathy (3)
- diagnostic (3)
- diagnostic medicine (3)
- diastolic dysfunction (3)
- diazepam (3)
- differential diagnosis (3)
- differentiation potential (3)
- dilated cardiomyopathy (3)
- disease progression (3)
- diseases (3)
- disorder (3)
- distraction (3)
- diversity gradients (3)
- dizziness (3)
- doctoral graduates (3)
- dogs (3)
- double-blind (3)
- driving (3)
- drought stress (3)
- drug adverse reaction (3)
- drug allergy (3)
- drug development (3)
- drug hypersensitivity (3)
- drug release (3)
- drug resistance (3)
- drug therapy (3)
- duchenne muscular dystrophy (3)
- dunce (3)
- dynamic programming (3)
- dyspnea (3)
- early detection (3)
- early diagnosis (3)
- early intervention (3)
- early-life stress (3)
- eating behavior (3)
- edge states (3)
- electrical and electronic engineering (3)
- electrical impedance tomography (3)
- electrocatalysis (3)
- electrochromic device (3)
- electrohydrodynamics (3)
- electromyography (3)
- electron density (3)
- electroporation (3)
- elevated plus-maze (3)
- elevation (3)
- elevational gradient (3)
- elongation (3)
- embodied cognition (3)
- embryonic stem cell (3)
- embryonic stem cells (3)
- embryos (3)
- emerin (3)
- emotion processing (3)
- emotion recognition (3)
- emotional processing (3)
- emphysema (3)
- empowerment (3)
- endophenotype (3)
- endophyte (3)
- endoradiotherapy (3)
- endothelial barrier (3)
- endothelial cell (3)
- endotheliale Vorläuferzellen (3)
- engineering (3)
- entomology (3)
- entrepreneurship (3)
- entropy (3)
- entropy production (3)
- environmental health (3)
- environmental justice (3)
- ependymoma (3)
- epidermis (3)
- ereigniskorrelierte Potentiale (3)
- esophagus (3)
- essential tremor (3)
- ethics (3)
- etiology (3)
- etomidate (3)
- evidence-based medicine (3)
- evoked potentials (3)
- evozierte Potentiale (3)
- ex vivo (3)
- executive functions (3)
- exercise intensity (3)
- exome sequencing (3)
- exosomes (3)
- expression analysis (3)
- extreme value theory (3)
- fMRT (3)
- fabry disease (3)
- face (3)
- fanconi anemia (3)
- fatty acid (3)
- fatty liver disease (3)
- fear of progression (3)
- feasibility (3)
- feeding (3)
- female (3)
- fermentation (3)
- ferroelectricity (3)
- ferromagnetism (3)
- fiber (3)
- fibroblast activation protein (3)
- finite element method (3)
- fire (3)
- fixation (3)
- flexibility (3)
- flow regulation (3)
- flow regulator (3)
- flowability (3)
- flowers (3)
- fluorescence correlation spectroscopy (3)
- fluorescence spectroscopy (3)
- fluoroquinolones (3)
- flux (3)
- foamy viruses (3)
- foamyvirus (3)
- food safety (3)
- force (3)
- forestry (3)
- formicidae (3)
- fpVCT (3)
- fragment reattachment (3)
- fragmentation (3)
- frailty (3)
- framing (3)
- free electron laser (3)
- frontotemporal dementia (3)
- fully convolutional neural networks (3)
- functional imaging (3)
- functional neuroimaging (3)
- functional training (3)
- fungal infections (3)
- fungal pathogens (3)
- fungal rhodopsins (3)
- furan (3)
- gametocyte (3)
- gamma astronomy (3)
- gamma radiation (3)
- gamma rays (3)
- gas (3)
- gastric bypass (3)
- gastroenterology (3)
- gastrointestinale Tumore (3)
- gefitinib (3)
- gekrümmte Kohlenwasserstoffe (3)
- gene expression profiling (3)
- generalization (3)
- genetic engineering (3)
- genetic modifiers (3)
- genetic testing (3)
- genetic variation (3)
- genome assembly (3)
- genome integrity (3)
- genome sequence (3)
- genotyping (3)
- geometry (3)
- geophysics (3)
- gestaltungsorientierte Bildungsforschung (3)
- girls (3)
- glaciers (3)
- glial fibrillary acidic protein (3)
- global convergence (3)
- glomerular filtration rate (3)
- glomeruli (3)
- glutamate transporters (3)
- glutathione (3)
- glycoproteins (3)
- gold (3)
- grading (3)
- graft (3)
- grammar (3)
- granzyme B (3)
- graphene (3)
- growth cone (3)
- growth factor (3)
- growth hormone deficiency (3)
- guanylyl cyclase (3)
- guided bone regeneration (3)
- guinea pig (3)
- gynogenesis (3)
- haemodialysis (3)
- haemostasis (3)
- handlungs- und entwicklungsorientierte Didaktik (3)
- hands (3)
- hangover (3)
- hardness (3)
- head and neck (3)
- healing (3)
- healthcare (3)
- hearing aid (3)
- hearing screening (3)
- heart transplantation (3)
- heat shock protein (3)
- heat shock response (3)
- helicase (3)
- helminths (3)
- hematopoiesis (3)
- hemodiafiltration (3)
- hemoglobin (3)
- hemolysin (3)
- hepatitis B virus (3)
- hepatocellular carcinoma (3)
- hepatotoxicity (3)
- herbivores (3)
- herbivory (3)
- heritability (3)
- herpesvirus (3)
- heterogeneity (3)
- hiPSC-CM (3)
- high-intensity interval training (3)
- hip arthroplasty (3)
- histone H2AX (3)
- histones (3)
- histopathology (3)
- historical document analysis (3)
- history of medicine (3)
- homology modeling (3)
- honeycomb lattice (3)
- hormones (3)
- hospital (3)
- host-pathogen interactions (3)
- human brain (3)
- human brain microvascular endothelial cells (3)
- human genetics (3)
- human immunodeficiency virus (3)
- human learning (3)
- human rights (3)
- humane mesenchymale Stammzellen (3)
- humidity (3)
- hydrological modelling (3)
- hydrology (3)
- hyperalgesia (3)
- hypercholesterolemia (3)
- hypertrophic cardiomyopathy (3)
- idiopathic pulmonary fibrosis (3)
- illness (3)
- image analysis (3)
- image quality (3)
- image segmentation (3)
- imaging the immune system (3)
- immediate early genes (3)
- immersive technologies (3)
- immune activation (3)
- immune escape (3)
- immune reconstitution (3)
- immune suppression (3)
- immunisation (3)
- immunoassay (3)
- immunocytochemistry (3)
- immunodeficiency (3)
- immunoglobulin (3)
- immunoreactive neurons (3)
- impedance spectroscopy (3)
- impurities (3)
- impurity profiling (3)
- inclusion (3)
- indication for surgery (3)
- individual differences (3)
- individual-based simulation (3)
- infant cry (3)
- infants (3)
- infectious disease (3)
- inflammatory diseases (3)
- inflammatory response (3)
- information extraction (3)
- informed consent (3)
- infrared (3)
- innate immune system (3)
- instrument (3)
- insulator (3)
- intelligence (3)
- intensity distribution (3)
- intentional binding (3)
- interaction networks (3)
- interactome (3)
- interface (3)
- interleukin 4 (3)
- interleukin-4 (3)
- interleukin-6 (3)
- interleukins (3)
- intermanual transfer (3)
- intuition (3)
- inventory (3)
- investigators (3)
- involvement (3)
- iodine (3)
- iron deficiency (3)
- irrigation (3)
- ischemia reperfusion injury (3)
- ischemia/reperfusion injury (3)
- islet transplantation (3)
- islets of Langerhans (3)
- isoliert (3)
- isomerization (3)
- isotopes (3)
- jasmonic acid (3)
- jet energy scale uncertainty (3)
- jets (3)
- juvenile hormone (3)
- kardiovaskuläre Risikofaktoren (3)
- ketogenic diet (3)
- kinase inhibitor (3)
- kinesin (3)
- kinetic model (3)
- knee joint (3)
- knee replacement (3)
- knock-out (3)
- kutikuläre Kohlenwasserstoffe (3)
- lamina (3)
- laminopathy (3)
- land-use change (3)
- landscape ecology (3)
- laparoscopic ventral hernia repair (3)
- larynx (3)
- laser (3)
- leaf beetle (3)
- learning strategies (3)
- leaves (3)
- left ventricular ejection fraction (3)
- leishmania major (3)
- length of stenosis (3)
- leptin (3)
- leukocytes (3)
- levodopa (3)
- library screening (3)
- life events (3)
- life history (3)
- ligand (3)
- ligand binding (3)
- light quark jet (3)
- linkage analysis (3)
- lipid metabolism (3)
- liraglutide (3)
- literature review (3)
- lithium-ion battery (3)
- liver metastasis (3)
- local field potentials (3)
- locomotor activity (3)
- low back pain (3)
- low-grade glioma (3)
- low-valent compounds (3)
- lower extremity (3)
- lung and intrathoracic tumors (3)
- lung injury (3)
- lymph node dissection (3)
- mCRP (3)
- mTOR (3)
- macrocycle (3)
- magnesium phosphate (3)
- magnetic susceptibility (3)
- main group elements (3)
- major histocompatibility complex (3)
- malignancy (3)
- malignant tumors (3)
- malnutrition (3)
- mammography (3)
- marine natural products (3)
- masculinity (3)
- mastocytosis (3)
- materials for optics (3)
- mathematical modelling (3)
- maturation (3)
- mechanical properties (3)
- mechanics (3)
- mechanosensing (3)
- media literacy (3)
- medical (3)
- megakaryopoiesis (3)
- melanogaster (3)
- melanoma cells (3)
- memory formation (3)
- mercury (3)
- merocyanines (3)
- mesencephalic locomotor region (3)
- mesoscopic (3)
- mesoscopics (3)
- messenger-RNA (3)
- metabolic modeling (3)
- metabolischer Test (3)
- metabolites (3)
- metabonomics (3)
- metacognition (3)
- metacomprehension (3)
- metallocenophanes (3)
- metallosupramolecular chemistry (3)
- metals (3)
- methionine restriction (3)
- methods (3)
- miR (3)
- miR-26 (3)
- micelles (3)
- microRNA-221 (3)
- microbial ecology (3)
- microbial rhodopsins (3)
- microclimate (3)
- microfluidics (3)
- microsatellites (3)
- microtubules (3)
- microvascular endothelial cells (3)
- midazolam (3)
- mild cognitive impairment (3)
- mimicry (3)
- mineralocorticoid receptor (3)
- minimal-invasiv (3)
- mitotane (3)
- mixed methods (3)
- mobile health (3)
- modular (3)
- molecular characterization (3)
- molecular cloning (3)
- molecular diagnostics (3)
- molecular epidemiology (3)
- molecular phylogeny (3)
- molecular structure (3)
- monoamine oxidase (3)
- morphogenesis (3)
- mosaicism (3)
- mothers (3)
- multi-unit recording (3)
- multijet background (3)
- multilocularis (3)
- multiple bonds (3)
- multiple linear regression (3)
- multiple system atrophy (3)
- multivariate analysis (3)
- muscarinic antagonists (3)
- muscarinic receptor subtypes (3)
- muscle strength (3)
- mutants (3)
- mutation analysis (3)
- mycotoxins (3)
- myopathy (3)
- nanoparticle (3)
- nanophotonics and plasmonics (3)
- nanotechnology (3)
- nanotube (3)
- naphthalene diimide (3)
- national park (3)
- national parks (3)
- natural history (3)
- natural variation (3)
- necroptosis (3)
- necrosis-factor-alpha (3)
- negative affect (3)
- neoadjuvant (3)
- neonate (3)
- nerve fibers (3)
- nest climate (3)
- network analysis (3)
- networking (3)
- neural circuits (3)
- neural crest (3)
- neurofascin (3)
- neurofilament light chain (3)
- neurological disorders (3)
- neuromodulation (3)
- neuromonitoring (3)
- neuronal (3)
- neuronal network (3)
- neuronal nitric oxide synthase (3)
- neuropathischer Schmerz (3)
- neuropathology (3)
- neuropeptide (3)
- neuroplasticity (3)
- neuropsychology (3)
- neutropenia (3)
- new media (3)
- newborn (3)
- next-generation sequencing (3)
- niche (3)
- nicht-kovalente Wechselwirkungen (3)
- nicotine addiction (3)
- non-prompt lepton (3)
- non-verbal communication (3)
- nonsmooth optimization (3)
- nuclear export (3)
- nuclear lamina (3)
- nucleotide excision repair (3)
- numerical cognition (3)
- nystagmus (3)
- obstructive pulmonary disease (3)
- occlusion (3)
- older adults (3)
- olfactory learning (3)
- olfactory memory (3)
- oligomers (3)
- oncolytic viruses (3)
- onkolytische Virotherapie (3)
- open abdomen (3)
- operant conditioning (3)
- optical (3)
- optoelectronics (3)
- oral anticancer drugs (3)
- oral bioavailability (3)
- ordinary differential equations (3)
- organic light emitting diodes (3)
- organic molecule (3)
- organic photodiodes (3)
- organic solar cell (3)
- organische Photovoltaik (3)
- organische Solarzelle (3)
- origin (3)
- orofacial clefts (3)
- oropharynx (3)
- orthodontics (3)
- oscillation (3)
- oscillations (3)
- osteogene Differenzierung (3)
- outcomes research (3)
- outpatient (3)
- output elasticities (3)
- ovarian carcinoma (3)
- oxygen/glucose deprivation (3)
- p38 MAPK (3)
- p97 (3)
- pICln (3)
- paclitaxel (3)
- paediatric cancer (3)
- paleoecology (3)
- palliativ (3)
- pandemic (3)
- parallel imaging (3)
- parastomal hernia (3)
- parents (3)
- pars plana vitrectomy (3)
- particles (3)
- pasture (3)
- patellar tendon (3)
- pathogen (3)
- pathogenicity island (3)
- pathogenicity islands (3)
- pathophysiology (3)
- patient education (3)
- patients (3)
- pattern (3)
- pemphigus vulgaris (3)
- pentacene (3)
- peptide receptor radionuclide therapy (3)
- performance evaluation (3)
- periodische Katatonie (3)
- peripheral nerve (3)
- peripheral neuropathy (3)
- peristalsis (3)
- peritonitis (3)
- permeation (3)
- peroxisome (3)
- perylene dyes (3)
- phage (3)
- phage display (3)
- pharmacodynamics (3)
- pharmacovigilance (3)
- phenomenology (3)
- pheromones (3)
- phonological awareness (3)
- phosphatase (3)
- phosphorus (3)
- photoemission (3)
- photoionization (3)
- photolysis (3)
- photoperiodism (3)
- photosynthesis (3)
- photothrombotic stroke (3)
- phylogenetics (3)
- physical fitness (3)
- phytohormones (3)
- pigmentation (3)
- piperidines (3)
- plant (3)
- plant extract (3)
- plaque (3)
- pleural empyema (3)
- point-of-care (3)
- polarized training (3)
- politics (3)
- pollen foraging (3)
- pollen tube (3)
- pollinator (3)
- poly(2-ethyl-2-oxazoline) (3)
- poly(2-oxazine) (3)
- poly(2-oxazoline) (3)
- poly(2-oxazoline)s (3)
- polymer processing (3)
- polymorphisms (3)
- polyploidy (3)
- poor prognosis (3)
- positive selection (3)
- postoperative nausea and vomiting (3)
- posttranslational modifications (3)
- posture (3)
- potassium channels (3)
- preschool (3)
- preschool children (3)
- preterm birth (3)
- primary cells (3)
- primary hyperparathyroidism (3)
- primary school (3)
- priming (3)
- primärer Hyperaldosteronismus (3)
- prion protein (3)
- pro-inflammatory cytokines (3)
- process mining (3)
- processing fluency (3)
- progenitor cells (3)
- progenitors (3)
- progeria (3)
- programmed cell death (3)
- promoter polymorphism (3)
- prosocial behavior (3)
- prospective study (3)
- prostaglandins (3)
- prostate-specific membrane antigen (PSMA) (3)
- prosthesis (3)
- proteasome (3)
- protected areas (3)
- protein adsorption (3)
- protein crystallography (3)
- protein folding (3)
- protein kinases (3)
- protein phosphorylation (3)
- protein purification (3)
- proteinuria (3)
- proximal gradient method (3)
- psychometrics (3)
- psychopathology (3)
- psychosocial stress (3)
- psychotherapy (3)
- pulse wave velocity (3)
- pyrene (3)
- qPCR (3)
- quality of democracy (3)
- quality of experience (3)
- quantitative analysis (3)
- quantum chemistry (3)
- quantum mechanics (3)
- quantum physics (3)
- quantum well (3)
- quantum wells (3)
- qubits (3)
- quercetin (3)
- rOCT1 (3)
- radical reactions (3)
- radiography (3)
- radiomics (3)
- radius (3)
- randomized controlled-trial (3)
- randomized trial (3)
- rapid prototyping (3)
- rare diseases (3)
- reactivation (3)
- reaktive Intermediate (3)
- real time PCR (3)
- real-time PCR (3)
- rearrangement (3)
- receptor tyrosine kinases (3)
- reference values (3)
- reflection (3)
- regulatory RNA (3)
- regulatory T cell (3)
- reinforcement learning (3)
- rejection (3)
- relaxation (3)
- relief (3)
- remineralization (3)
- remodelling (3)
- renal (3)
- renal cancer (3)
- reporter genes (3)
- reporting and data system (3)
- reproductive success (3)
- research (3)
- restriction (3)
- resuscitation (3)
- retrospective analysis (3)
- retroviral vectors (3)
- rhinitis (3)
- rhodesain (3)
- ribosome (3)
- riboswitch (3)
- rice (3)
- rickets (3)
- robustness (3)
- root growth (3)
- rubber hand illusion (3)
- safety behavior (3)
- salt (3)
- salthydratic melt (3)
- salvage radiotherapy (3)
- sample (3)
- sarcoidosis (3)
- satellite data (3)
- satellite remote sensing (3)
- scFv (3)
- scanning electron microscopy (3)
- scleroderma (3)
- secondary lung tumors (3)
- sedimentology (3)
- selectivity (3)
- selenoproteins (3)
- self-assessment (3)
- self-efficacy (3)
- semantic segmentation (3)
- semi-natural habitats (3)
- semiotics (3)
- sense of agency (3)
- sensor fusion (3)
- sensory cues (3)
- sensory neurons (3)
- sentinel (3)
- septic (3)
- sequence databases (3)
- sequestration (3)
- seroprevalence (3)
- serotonergic system (3)
- serotonin transporter gene (3)
- serum concentration (3)
- serum resistance (3)
- service (3)
- shear bond strength (3)
- shoulder arthroplasty (3)
- sialic acid (3)
- side effects (3)
- signal peptides (3)
- signal to noise ratio (3)
- silicon compounds (3)
- single photon emission (3)
- single top production (3)
- single top quark (3)
- single-molecule biophysics (3)
- single-sided deafness (3)
- situation awareness (3)
- sleeve gastrectomy (3)
- small RNAs (3)
- small-molecule activation (3)
- smooth muscle (3)
- snRNP (3)
- social (3)
- sodium channel (3)
- spatial attention (3)
- speckle tracking (3)
- speech perception (3)
- speech recognition (3)
- speech recognition test (3)
- sphingolipid (3)
- sphingosine-1-phosphate (3)
- spin polarization (3)
- spin-orbit coupling (3)
- spine (3)
- spiroergometry (3)
- squamous cell carcinoma (3)
- standard model (3)
- startle (3)
- statistical data (3)
- statistics (3)
- stem (3)
- stem cell therapy (3)
- stenosis (3)
- stereoselective synthesis (3)
- stereotactic body radiation therapy (3)
- stereotactic body radiotherapy (3)
- stereotactic irradiation (3)
- stiffness (3)
- stingless bees (3)
- stochastic processes (3)
- stomach (3)
- strains (3)
- strategies (3)
- strategy (3)
- stress resistance (3)
- striatum (3)
- stroke unit (3)
- stroma (3)
- structure-activity relationship (3)
- structured illumination microscopy (3)
- study (3)
- substituent (3)
- subunit (3)
- subventricular zone (3)
- sucrose responsiveness (3)
- superparamagnetism (3)
- superresolution (3)
- suppressor cells (3)
- surface modification (3)
- surface science (3)
- surgical site infection (3)
- survival rate (3)
- survival rates (3)
- susceptibility loci (3)
- swarming (3)
- swine (3)
- synaptic inhibition (3)
- synaptic transmission (3)
- syndrome (3)
- syntaktische Funktion (3)
- syntaktische Struktur (3)
- synthetic methods (3)
- tMCAO (3)
- tapeworm (3)
- targeting (3)
- taxation (3)
- teacher education (3)
- team sport (3)
- temozolomide (3)
- temperate forests (3)
- temporal binding (3)
- temporal bone (3)
- tendon (3)
- theology (3)
- theoretical chemistry (3)
- therapeutic strategy (3)
- thermogenesis (3)
- thin film (3)
- thin films (3)
- threat (3)
- three-dimensional imaging (3)
- thyroid gland (3)
- time perception (3)
- time-resolved photoelectron spectroscopy (3)
- timing (3)
- tooth extraction (3)
- top quark (3)
- top quark pair (3)
- topography (3)
- topological matter (3)
- topologische Isolatoren (3)
- toxins (3)
- trabectome (3)
- trade-offs (3)
- trafficking (3)
- tranexamic acid (3)
- trans-splicing (3)
- transcriptional control (3)
- transfer (3)
- transgen (3)
- transiente Absorption (3)
- transition (3)
- transkranielle Gleichstromstimulation (3)
- transmission electron microscopy (3)
- transportation (3)
- transtemporal (3)
- trap (3)
- trauma (3)
- treatment outcome (3)
- treatment response (3)
- triglycerides (3)
- tropical ecology (3)
- tumor cells (3)
- tundra (3)
- turbulence (3)
- two-photon absorption (3)
- ulcerative colitis (3)
- ultrafiltration (3)
- umbilical hernia (3)
- university library (3)
- upper extremity (3)
- urban (3)
- urbanization (3)
- uremic toxin (3)
- urinary tract infections (3)
- usability (3)
- use (3)
- user-centered design (3)
- vaccines (3)
- vacuole (3)
- vandetanib (3)
- vascular (3)
- vascular plants (3)
- vegetation (3)
- vesicle trafficking (3)
- vibration (3)
- video analysis (3)
- viral load (3)
- viral replication (3)
- virology (3)
- virtual environments (3)
- virtuelle Realität (3)
- virtuelles Screening (3)
- visual acuity (3)
- visual orientation (3)
- von Willebrand factor (3)
- vulnerability curve (3)
- waggle dance (3)
- water purification (3)
- weight gain (3)
- whole exome sequencing (3)
- whole-exome sequencing (3)
- wrist (3)
- xenotransplantation (3)
- xerostomia (3)
- yoga (3)
- zeitaufgelöste Spektroskopie (3)
- Ägypten <Altertum> (3)
- Ängstliche Depression (3)
- Ästhetische Bildung (3)
- Ätiologie (3)
- Ökosystem (3)
- Österreich (3)
- Übergangsmetallverbindungen (3)
- Übung (3)
- α-synuclein (3)
- γδ T cells (3)
- "-omics" (2)
- (Ga (2)
- (Ga,Mn)As (2)
- 1,2-Azaborinine (2)
- 10-bis(dicarboximide)> (2)
- 11C-HED (2)
- 123I-mIBG (2)
- 123I-metaiodobenzylguanidine (2)
- 177Lu (2)
- 18F-FDS (2)
- 19th century (2)
- 2"-> (2)
- 2':6' (2)
- 2-APB (2)
- 2015 (2)
- 2B (2)
- 2D (2)
- 2Dimensionale Spektroskopie (2)
- 3 Tesla (2)
- 3-DPG (2)
- 31P-MRS (2)
- 3D - rapid prototyping (2)
- 3D Bioprinting (2)
- 3D Modell (2)
- 3D Pulverdruck (2)
- 3D Tumormodell (2)
- 3D analysis (2)
- 3D fluoroscopy (2)
- 3D in vitro model (2)
- 3D model generation (2)
- 3D tumour model (2)
- 3D-Bildgebung (2)
- 3D-Gewebemodell (2)
- 3D-Kultur (2)
- 3D-Modell (2)
- 3D-Rekonstruktion (2)
- 3D-Ultraschall (2)
- 3D-conformal radiotherapy (2)
- 3D-printed tooth (2)
- 4 (2)
- 4-0xadiazine-2-carboxylate (2)
- 4-Aminobiphenyl (2)
- 4-HNE (2)
- 4-aminobiphenyl (2)
- 4:9 (2)
- 4D flow (2)
- 5-Azacytidine (2)
- 5-Azadeoxycytidin (2)
- 5-FU (2)
- 5-HT transporter (2)
- 5-HT1A receptor (2)
- 5-azadeoxycytidine micronucleus (2)
- 5G (2)
- 6 (2)
- 68Ga-DOTATATE (2)
- 7 T (2)
- 7T (2)
- 8p22 (2)
- A1 adenosine receptors (2)
- A20 (2)
- AAA (2)
- AAA-Knochen (2)
- ABCG2 (2)
- ACID (2)
- ADAM9 (2)
- ADC (2)
- ADMA (2)
- ADST (2)
- AFLP (2)
- AICD (2)
- AKT1 (2)
- ALCL (2)
- ALMT (2)
- AMACR (2)
- AMADEUS (2)
- AMSOL (2)
- ANOVA (2)
- AP-1 (2)
- AP1 (2)
- APC (2)
- AQP4 (2)
- ARONJ (2)
- ASCA (2)
- ASCs (2)
- ASM (2)
- ATF4 (2)
- ATF5 (2)
- ATM (2)
- ATRT (2)
- Ab interno trabeculectomy (2)
- Ab-initio-Rechnung (2)
- Abelsche Gruppe (2)
- Ablenkung (2)
- Abrieb (2)
- Abschlussprüfung (2)
- Abscisic Acid (2)
- Abscisic acid (2)
- Absolute Konfiguration (2)
- Absolutquantifizierung (2)
- Absorption (2)
- Abstoßung (2)
- Abszess (2)
- Abtreibung (2)
- Acetaminophen (2)
- Acetylation (2)
- Acetylcystein (2)
- Acetylierung (2)
- Achilles (2)
- Achtsamkeit (2)
- Achtsamkeitsbasiertes Training (2)
- Ackerbohne (2)
- Acromyrmex fracticornis (2)
- Actin nucleation (2)
- Actinomyceten (2)
- Active Galactic Nuclei (2)
- Active galactic nucleus (2)
- Activity (2)
- Acute Kidney Injury (2)
- Acute lymphocytic leukaemia (2)
- Acute myeloid leukemia (2)
- Acute myeloid leukemia (AML) (2)
- Adamov (2)
- Additive Manufacturing (2)
- Adenocarcinom (2)
- Adenosine receptor (2)
- Adenylatcyclase (2)
- Aderhaut (2)
- Aderhautmelanom (2)
- Adhesion GPCR (2)
- Adhesion-GPCR (2)
- Adhäsionsmoleküle (2)
- Adhäsivbrücke (2)
- Adhäsive Restauration (2)
- Adhäsivfraktur (2)
- Adipogenesis (2)
- Adipokine (2)
- Adiponektin (2)
- Adipositaschirurgie (2)
- Adjuvant (2)
- Adjuvante Therapie (2)
- Adolescence (2)
- Adrenostatika (2)
- Adulte Neurogenese (2)
- Adults (2)
- Advanced glycosylation end products (2)
- Aequos G1 (2)
- Aerosol (2)
- Aflatoxin (2)
- African Trypanosomes (2)
- African trypanosomes (2)
- Afrikanische Union (2)
- Agalsidase beta (2)
- Agent (2)
- Agent <Informatik> (2)
- Agent <Künstliche Intelligenz> (2)
- Agoraphobia (2)
- Agrobacterium (2)
- Akademisierung (2)
- Akkadisch (2)
- Akkulturation (2)
- Aktiv (2)
- Akustisch evoziertes Potenzial (2)
- Akute Extremitätenischämie (2)
- Akutes ischämisches Nierenversagen (2)
- Akzeptor <Chemie> (2)
- Alain ; Boudjedra (2)
- Alcohol (2)
- Aldosterone (2)
- Aldosteronismus (2)
- Aldosteronsynthaseinhibitor (2)
- Algen (2)
- Algerien (2)
- Algorithm (2)
- Alignment (2)
- Alkoholkonsum (2)
- Alkoxysilane (2)
- Allelische Verlustanalyse (2)
- Allgemeines Gleichgewichtsmodell (2)
- Allgemeinmedizin (2)
- Alloantigen (2)
- Allogene Stammzelltransplantation (2)
- Allograft rejection (2)
- Allosterie (2)
- Allosterischer Effektor (2)
- Allotransplantation (2)
- Alltag (2)
- Alpha-2-Rezeptor (2)
- Alternans (2)
- Alternative (2)
- Altersdepression (2)
- Altersvorsorge (2)
- Altfranzösisch (2)
- Aluminafluorene (2)
- Aluminiumnitrid (2)
- Aluminiumverbindungen (2)
- Alveolarmakrophagen (2)
- Alzheimer's Disease (2)
- Amazon Molly (2)
- Ames test (2)
- Amino Acids (2)
- Aminobisphosphonate (2)
- Aminobuttersäure <gamma-> (2)
- Aminoglykoside (2)
- Ammoniten (2)
- Ammonshorn (2)
- Amphotericin B (2)
- Amplification (2)
- Amputation (2)
- Amyotrophe Lateralsklerose (2)
- Analfistel (2)
- Anaplastisches Schilddrüsenkarzinom (2)
- Anastomosenheilung (2)
- Anatolien (2)
- Androgene (2)
- Aneuploidy (2)
- Angabe (2)
- Angewandte Mikrobiologie (2)
- Angiotensin-II-Blocker (2)
- Angstsyndrom (2)
- Anidulafungin (2)
- Animal models (2)
- Anisotrope Diffusion (2)
- Anode (2)
- Anoplolepis gracilipes (2)
- Antarctic ice sheet (2)
- Antarktis (2)
- Antenne (2)
- Anthracen (2)
- Anthropometrie (2)
- Anthropozän (2)
- Anti-k Jet (2)
- Antiaromatizität (2)
- Antibiotic (2)
- Antibiotics (2)
- Antibiotikafreisetzung (2)
- Antibiotikaprophylaxe (2)
- Antibiotikaresistenz (2)
- Antibiotikaresistenzen (2)
- Antidepressivum (2)
- Antiepileptika (2)
- Antigen CD14 (2)
- Antigen CD19 (2)
- Antigen CD25 (2)
- Antikenrezeption (2)
- Antikoagulation (2)
- Antikonvulsiva (2)
- Antikörper-Fusionsproteine (2)
- Antimon (2)
- Antimonide (2)
- Antimonverbindungen (2)
- Antipsychotics (2)
- Antisense (2)
- Antisense RNA (2)
- Antisepsis (2)
- Anton Ulrich, Braunschweig-Lüneburg, Herzog (2)
- Anwendung (2)
- Anwendungssoftware (2)
- Anxiety disorder (2)
- Anxiety sensitivity (2)
- Anästhesiologie (2)
- Anästhetika-induzierte Postkonditionierung (2)
- Anästhetika-induzierte Präkonditionierung (2)
- Aortendissektion (2)
- Aortenklappe (2)
- Aortic valve stenosis (2)
- Aortokoronarer Bypass (2)
- Apolipoprotein (2)
- Apolipoprotein E (2)
- Apologie (2)
- Apology (2)
- Apoplast (2)
- Appetitlosigkeit (2)
- Approach-Avoidance-Task (2)
- Approximation (2)
- Aptamer (2)
- Aquaporine (2)
- Arabismus (2)
- Arachidonsäure (2)
- Arbeitsbelastung (2)
- Arbeitsrecht (2)
- Archaea (2)
- Architekt (2)
- Argentina (2)
- Arginine (2)
- Argumentation (2)
- Aristeas (2)
- Aristeas-Brief (2)
- Arno Schmidt (2)
- Aromaticity (2)
- Aromatizität (2)
- Arrestine (2)
- Arten-Energy-Theory (2)
- Artenreichtum (2)
- Arteria carotis interna (2)
- Arterielle Gefäßsteifigkeit (2)
- Arterielle Verschlusskrankheit (2)
- Arteriosclerosis (2)
- Arthroplastik (2)
- Arthur (2)
- Arzneibuch (2)
- Arzt (2)
- Asien (2)
- Aspartatproteasen (2)
- Aspergillosis (2)
- Aspirin (2)
- Assemblage (2)
- Assembly (2)
- Association (2)
- Associative learning (2)
- Assoziatives Lernen (2)
- Astronomie (2)
- Astrozyt (2)
- Astrozyten (2)
- Asylrecht (2)
- AtSUC4 (2)
- Ataciguat (2)
- Atemstörung (2)
- Atharvaveda (2)
- Atomic and molecular interactions with photons (2)
- Atrophie (2)
- Attention (2)
- Attention-deficit/hyperactivity disorder (2)
- Attenuierung (2)
- Audiovisuelle Medien (2)
- Audit sampling (2)
- Auditor Independence (2)
- Auditory brainstem responses AER (2)
- Auditory steady-state responses ASSR (2)
- Aufführung (2)
- Aufgabenorientierung (2)
- Aufgabenwechsel (2)
- Aufmerksamkeitsdefizit-/Hyperaktivitätsstörung (2)
- Aufmerksamkeitskontrolle (2)
- Aufmerksamkeitslenkung (2)
- Aufmerksamkeitsverzerrung (2)
- Augenbewegung (2)
- Augenfolgebewegung (2)
- Augenhintergrund (2)
- Augenkrankheit (2)
- Augenlid (2)
- Ausfallsicheres System (2)
- Ausfallsicherheit (2)
- Ausgrabungen (2)
- Aushärtung (2)
- Auskunftsdienst (2)
- Ausländerstudium (2)
- Austauschreaktion (2)
- Autism spectrum disorders (2)
- Autismus-Spektrum-Störung (2)
- Auto-Scaling (2)
- Autobiographie ; Robbe-Grillet (2)
- Autogene Transplantation (2)
- Autologous hematopoietic stem cell transplantation (2)
- Autoradiographie (2)
- Autorenlesung (2)
- Autorotation (2)
- Autotransporterprotein (2)
- Außenpolitik (2)
- Außerschulische Bildung (2)
- Avemar (2)
- Aversive Konditionierung (2)
- Avicenna (2)
- Awareness (2)
- Axion (2)
- Axon degeneration (2)
- Axonal degeneration (2)
- Azaborinine (2)
- Azide (2)
- Azoalkene (2)
- B cell differentiation (2)
- B cell receptors (2)
- B-Lymphozyten-Rezeptor (2)
- B-N-Kupplung (2)
- B-Zelldifferenzierung (2)
- B-scan-Ultraschallkardiographie (2)
- BAD (2)
- BALF (2)
- BAV-Förderbetrag (2)
- BBCH (2)
- BCL6 (2)
- BCMA (2)
- BDG (2)
- BDNF stimulation (2)
- BERAphon (2)
- BGK approximation (2)
- BH3-only proteins (2)
- BK-Kanal (2)
- BMI (2)
- BMP signaling (2)
- BMP variants (2)
- BMPR-IA (2)
- BNIP3 (2)
- BNP (2)
- BOLD signal (2)
- BPD (2)
- BRCA2 (2)
- BRENDA (2)
- BTN3 (2)
- Bacillus (2)
- Bacillus megaterium (2)
- Bacterial meningitis (2)
- Bacterial pathogens (2)
- Bakterielle Hirnhautentzündung (2)
- Bakteriengift (2)
- Balanced lethal System (2)
- Balanced lethal Systeme (2)
- Ballistischer Transport (2)
- Bandstruktur (2)
- Barbaricum (2)
- Bariatric surgery (2)
- Bariumtitanat (2)
- Barrett's esophagus (2)
- Barrett-Ösophagus (2)
- Barrettösophagus (2)
- Barrieren (2)
- Basalmembran (2)
- Base text (2)
- Basilius, Caesariensis (2)
- Bauchaorta (2)
- Bauchwand (2)
- Baum (2)
- Baumkrone (2)
- Baumwollratte (2)
- Bcl-2 Familie (2)
- Bcl-2 family (2)
- Beamtenrecht (2)
- Beatmung (2)
- Bedürfnisse (2)
- Bee abundance (2)
- Bees (2)
- Befestigungszement (2)
- Befindlichkeit (2)
- Befragung (2)
- Begabtenförderung (2)
- Begriff (2)
- Behindertenbeauftragte (2)
- Belastungselektrokardiogramm (2)
- Beliefs (2)
- Belyi map (2)
- Benchmark (2)
- Benfotiamin (2)
- Benin (2)
- Benutzeroberfläche (2)
- Benutzerschnittstelle (2)
- Benzene (2)
- Benzochinone (2)
- Benzvalen (2)
- Beobachter (2)
- Berchtesgaden (2)
- Berichterstattung (2)
- Berlin (2)
- Berufsanfang (2)
- Beschneidung (2)
- Beschäftigung (2)
- Besteuerung (2)
- Bestimmung (2)
- Bestäuber (2)
- Bestäubungsökologie (2)
- Besucherverhalten (2)
- Beta-2-Rezeptor (2)
- Beta-Hydroxybutyrat (2)
- Beta-catenin (2)
- Betablocker (2)
- Betreuungsrecht (2)
- Betrieb (2)
- Betriebsformenwandel (2)
- Betriebsrente (2)
- Betriebssystem (2)
- Bewegungsapparat (2)
- Bi2Se3 (2)
- Biaxiale Biegefestigkeit (2)
- Bibel (2)
- Bibel. Judit (2)
- Bibliografie (2)
- Biegefestigkeit (2)
- Bienenbrut (2)
- Big Five (2)
- Biholomorphe Abbildung (2)
- Bilanzierung (2)
- Bildbetrachtung (2)
- Bildhauer (2)
- Bildnerisches Gestalten (2)
- Bindeproteine (2)
- Bindestelle (2)
- Binomialverteilung (2)
- BioGlue (2)
- BioID (2)
- BioVaSc (2)
- Bioaktive Verbindungen (2)
- Bioaktivität (2)
- Bioassay (2)
- Bioavailability (2)
- Biochemistry (2)
- Biodiversity (2)
- Biodruck (2)
- Bioengineering (2)
- Biographisches Interview (2)
- Bioink (2)
- Biokatalyse (2)
- Biokompatibel (2)
- Biologika (2)
- Biologische Schädlingsbekämpfung (2)
- Biologisches System (2)
- Biomechanics (2)
- Biomembran (2)
- Biometrie (2)
- Biomolekül (2)
- Bioorganik (2)
- Bioorganische Chemie (2)
- Bioreactor (2)
- Biosphärenreservat Rhön (2)
- Biostatistik (2)
- Biosynthesis (2)
- Biotechnologische Industrie (2)
- Bismuthene (2)
- Bismutselenide (2)
- Bismutverbindungen (2)
- Bisphenol A (2)
- Bisphosphonates (2)
- Bispidinderivate (2)
- Bitopische Liganden (2)
- Bivalves (2)
- Blake (2)
- Blastozyste (2)
- Bleiakkumulator (2)
- Blinddarmentzündung (2)
- Blood pressure (2)
- Blumeria graminis (2)
- Blut-Nerven-Barriere (2)
- Blut-Nerven-Schranke (2)
- Blutalkohol (2)
- Blutkontakt (2)
- Blutplättchen (2)
- Blutung (2)
- Bmi1 (2)
- Board of directors (2)
- Bocca (2)
- Bodenfeuchte (2)
- Bodengeografie (2)
- Bodenwasser (2)
- Body weight (2)
- Body-Mass-Index (2)
- Bodyplethysmographie (2)
- Bombus (2)
- Bombus terrestris (2)
- Bond Activation (2)
- Bone marrow (2)
- Bone morphogenetic protein (2)
- Bone-Lock-System (2)
- Bone-marrow-transplantation (2)
- Bor-Stickstoff-Verbindungen (2)
- Bor-Übergangsmetallkomplexe (2)
- Boranes (2)
- Bordetella petrii (2)
- Borkenkäfer (2)
- Borolderivate (2)
- Borrelia burgdorferi (2)
- Borrelien (2)
- Borverbindungen (2)
- Borylanion (2)
- Borylenkomplex (2)
- Borylradikale (2)
- Bose-Einstein-Kondensation (2)
- Box-Jenkins-Verfahren (2)
- Box–Jenkins Program (2)
- Bradykinin (2)
- Brain endothelial cells (2)
- Brain natriuretic Peptide (2)
- Brainstem-Evoked-Response-Audiometry BERA (2)
- Brassica napus (2)
- Brazil (2)
- Breast-cancer (2)
- Breast-tumors (2)
- Breastcancer (2)
- Bronchialkarzinom (2)
- Bruchfestigkeit (2)
- Bruchverhalten (2)
- Brushite (2)
- Brust (2)
- Brustaorta (2)
- Brustbein (2)
- Brutbiologie (2)
- Buchpreis (2)
- Bulimia nervosa (2)
- Bullöses Pemphigoid (2)
- Bundesverfassungsgericht (2)
- Burst (2)
- Business Improvement District (2)
- Business Improvement Districts (2)
- Butyrylcholinesterase (2)
- BvgAS-System (2)
- Bärtierchen (2)
- Bürgertum (2)
- Bū-Ǧadra, Rašīd (2)
- C-60 fullerene (2)
- C-F bond activation (2)
- C-H activation (2)
- C-RAF (2)
- C-X-C motif chemokine receptor 4 (2)
- C-coupled naphthylisoquinoline alkaloids (2)
- C-reaktives Protein (2)
- C. callunae (2)
- C. efficiens (2)
- C. glutamicum (2)
- C/Si-Austausch (2)
- C/Si-Bioisosteric Investigations (2)
- C/Si-Bioisostric Investigations (2)
- C1-Inhibitor (2)
- C1-inhibitor (2)
- C3 (2)
- C57BL/6 mice (2)
- C5a (2)
- C6 (2)
- C60 (2)
- CA19-9 (2)
- CABG (2)
- CAD-CAM (2)
- CAD/CAM restoration material (2)
- CADe (2)
- CAIPIRINHA (2)
- CARS-Spektroskopie (2)
- CBCT (2)
- CCL4 (2)
- CCN1 (2)
- CCR4 (2)
- CD117 (2)
- CD147 (2)
- CD20 (2)
- CD274 (2)
- CD28 superagonist (2)
- CD28-Superagonist (2)
- CD28-superagonist (2)
- CD30 (2)
- CD38 (2)
- CD4(+) T-cells (2)
- CD4+ (2)
- CD46 (2)
- CD70 (2)
- CD8 T-Zellen (2)
- CD83mRNA (2)
- CD84 (2)
- CDC42 (2)
- CDI (2)
- CDL (2)
- CHO-Zelle (2)
- CHO-Zellen (2)
- CI (2)
- CIP2A (2)
- CK2 (2)
- CKD (2)
- CLL (2)
- CLN3 (2)
- CNN (2)
- CNS cancer (2)
- CNS disease (2)
- CNS disorders (2)
- CORDEX Africa (2)
- CORM (2)
- COVID-19-Pandemie (2)
- CP-Parität (2)
- CRC (2)
- CRE (2)
- CREB (2)
- CRISPR (2)
- CSF-1 (2)
- CSI (2)
- CSS (2)
- CSVD (2)
- CTEPH (2)
- CVD-Verfahren (2)
- CX3CR1 (2)
- CXCL10 (2)
- CXCL12 (2)
- CXCL13 (2)
- CXCR2 (2)
- CXCR7 (2)
- CYP11B1 (2)
- CYP24A1 (2)
- CYP2W1 (2)
- CaMKII (2)
- Ca\(^{2+}\) signalling (2)
- Caco2 cells (2)
- Cadherin (2)
- Cadherin-13 (2)
- Cadherin-13 (CDH13) (2)
- Cadmiumsulfid (2)
- Cadmiumtellurid (2)
- Calcitonin (2)
- Calciumion (2)
- Calearo (2)
- Calpain (2)
- Cambrian (2)
- Canada (2)
- Cancer immunotherapy (2)
- Cancer treatment (2)
- Capacity Management (2)
- Capecitabin (2)
- Capillary Electrophoresis (2)
- Carbamate (2)
- Carbazolderivate (2)
- Carbenkomplexe (2)
- Carbocations (2)
- Carborane (2)
- Carcinogenität (2)
- Cardiac (2)
- Cardiac Surgery (2)
- Cardiac hypertrophy (2)
- Cardiomyocyte (2)
- Cardiovascular disease (2)
- Cardiovascular diseases (2)
- Cardiovascular risk factors (2)
- Carfilzomib (2)
- Carnica-Biene (2)
- Cartilage (2)
- Cartilage Tissue Engineering (2)
- Cartilage regeneration (2)
- Cascading Style Sheets (2)
- Caspase-1 (2)
- Caspases (2)
- Catechine (2)
- Catechol-0-Methyltransferase (2)
- Caveolae (2)
- Cayley graph (2)
- Cdc42 (2)
- Cdu1 (2)
- Cefotaxim (2)
- Cell (2)
- Cell adhesion (2)
- Cell migration (2)
- Cell therapy (2)
- Cellculture (2)
- Cement (2)
- Cephalometric (2)
- Cephalosporine (2)
- Cerebellum (2)
- Cerlegierung (2)
- ChIP-sequencing (2)
- ChR2 (2)
- Chagas disease (2)
- Chaotisches System (2)
- Charcot-Marie-Tooth disease (2)
- Checkpoint-Inhibitor (2)
- Chelatbildner (2)
- Chemical Synthesis (2)
- Chemische Analyse (2)
- Chemische Reaktion (2)
- Chemisorption (2)
- Chemokinrezpetor (2)
- Chemoresistenz (2)
- Chemotherapieresistenz (2)
- Childhood (2)
- Childhood medulloblastoma (2)
- Chili RNA Aptamer (2)
- Chimerism (2)
- Chirale Verbindungen (2)
- Chirp-Reiz (2)
- Chirurgiegeschichte (2)
- ChlaDUB1 (2)
- Chlamydia pneumoniae (2)
- Chlorinderivate (2)
- Cholesterol (2)
- Cholinesterase (2)
- Chondrogenese (2)
- Chondrogenesis (2)
- Chondrogenic Differentiation (2)
- Chorasan (2)
- Christentum (2)
- Christianity (2)
- Chromatin structure (2)
- Chromosom 8 (2)
- Chromosomenanalyse (2)
- Chromosomenverlust (2)
- Chronic heart failure (2)
- Chronic kidney disease (2)
- Chronische Nierenerkrankung (2)
- Chronotrope Inkompetenz (2)
- Chrysididae (2)
- Chrétien <de Troyes> (2)
- Ciclosporin (2)
- Circadian clock (2)
- Circadianer Rhythmus (2)
- Circular-Dichroismus (2)
- Cirl (2)
- Citalopram (2)
- Cl Lowe limit (2)
- Claudin (2)
- Claudin-1 (2)
- Claudine <Biologie> (2)
- Cleft (2)
- Clinical Neuroradiology (2)
- Clinical trial (2)
- Clostridium-difficile-Infektion (2)
- Cloud Gaming (2)
- Cluster <Wirtschaft> (2)
- Cluster C Persönlichkeitsstörungen (2)
- Clusteranalyse (2)
- Co-Kultur (2)
- Cobalt (2)
- Cochlea Implantat (2)
- Code examples (2)
- Codierung (2)
- Coffin-Lowry syndrome (2)
- Cofilin (2)
- Cognitive conflict (2)
- Colombia (2)
- Colonization (2)
- Colorectal carcinoma (2)
- Columnare Phase (2)
- Combination (2)
- Comet assay (2)
- Comet-Assay (2)
- Compliance (2)
- Compliance <Patient> (2)
- Composite international diagnostic interview (2)
- Computed tomography (2)
- Computerphysik (2)
- Concealed Information Test (2)
- Conductivity (2)
- Confidence interval (2)
- Conformal field theory (2)
- Congo (2)
- Conical Intersections (2)
- Conjugation (2)
- Connexin (2)
- Conservation (2)
- Consistent partial least squares (2)
- Constant Score (2)
- Constant score (2)
- Constant-Score (2)
- Constraints (2)
- Contactin-1 (2)
- Contaminants (2)
- Content Management (2)
- Continuous Performance Test (2)
- Controllability (2)
- Controlling (2)
- Convolutional Neural Network (2)
- Coordination Chemistry (2)
- Copeptin (2)
- Copolymerisation (2)
- Copyright (2)
- Corannulene (2)
- Corporate Social Responsibility (2)
- Corpus (Linguistics) (2)
- Corpus striatum (2)
- Correlated Fermions (2)
- Correlative microscopy (2)
- Cortactin (2)
- Cortex (2)
- Corti-Organ (2)
- Corticosteroide (2)
- Cortison (2)
- Corynebacterium callunae (2)
- Corynebacterium efficiens (2)
- Corynebacterium glutamicum (2)
- Cosmology (2)
- Coupled Cluster (2)
- Covid-19 Pandemie (2)
- CpG (2)
- CpG-ODN (2)
- Crab-Nebel (2)
- Craniomandibuläre Dysfunktion (2)
- Craniopharyngioma (2)
- Craving (2)
- Crohn´s disease (2)
- Crohn’s disease (2)
- Cross-section (2)
- Crosslinking (2)
- Crosstalk (2)
- Crouzon (2)
- Crush (2)
- Cryo-EM (2)
- Cryptochrom (2)
- Crystal Structure (2)
- CsrA (2)
- CuPc (2)
- Cue-Reaktivität (2)
- Cuprate (2)
- Curriculum (2)
- Cushing’s disease (2)
- Cuticle (2)
- Cuticular waxes (2)
- Cyaninfarbstoff (2)
- Cyclische Verbindungen (2)
- Cyclization (2)
- Cyclo-GMP-Derivate (2)
- Cyclonucleotide (2)
- Cyclopentadienderivate (2)
- Cyclophosphamid (2)
- Cyclophosphamide (2)
- Cymantren (2)
- Cys-loop receptor (2)
- Cysteinderivate (2)
- Cytochrom C (2)
- Cytochrom P-450 (2)
- Cytochrome C (2)
- Cytokeratin (2)
- Cytokeratine (2)
- Cytoplasma (2)
- Cytotoxicity (2)
- Césaire, Aimé (2)
- D-Norm (2)
- D665 (2)
- DAPI staining (2)
- DASH (2)
- DCIS (2)
- DHAP (2)
- DIRA (2)
- DM-domain gene (2)
- DM2 (2)
- DMS (2)
- DNA Binding (2)
- DNA Methylation (2)
- DNA Repair (2)
- DNA Reparatur (2)
- DNA Schaden (2)
- DNA antibodies (2)
- DNA barcoding (2)
- DNA delivery (2)
- DNA double-strand break (2)
- DNA fingerprinting (2)
- DNA helicase (2)
- DNA methyltransferases (2)
- DNA sequencing (2)
- DNA storage (2)
- DNA-Binding (2)
- DNA-PK (2)
- DNA-Repair (2)
- DNA-Reparaturgene (2)
- DNA-Schäden (2)
- DNA-Typisierung (2)
- DNA-repair (2)
- DNA-typing (2)
- DNA/RNA sensors (2)
- DNMT3A (2)
- DNMT3B (2)
- DNS-Strangbruch (2)
- DNS-Topoisomerasen (2)
- DOT1 (2)
- DOTATOC (2)
- DRD4 (2)
- DREAM (2)
- DROSHA (2)
- DSM-IV (2)
- Dacron (2)
- Damage (2)
- Dante, Alighieri (2)
- Dark-Matter (2)
- Darmepithel (2)
- Darmwandnervensystem (2)
- Darstellungsmatrix (2)
- Data-Warehouse-Konzept (2)
- Data-driven Operations Management (2)
- Database (2)
- Datenfusion (2)
- Datenschutz (2)
- Dativ (2)
- Debonding (2)
- Decision Support Systems (2)
- Dectin-1 (2)
- Deep Learning (2)
- Deep sequencing (2)
- Deep sternal wound infection (2)
- Deformationsquantisierung (2)
- Deformität (2)
- Defäkographie (2)
- Dehydrokupplung (2)
- Delay Discounting (2)
- Deletion <Genetik> (2)
- Delta-Valve (2)
- Demokratische Republik Kongo (2)
- Demyelination (2)
- Demyelinisierung (2)
- Dentale Implantate (2)
- Dentalwerkstoff (2)
- Dentin (2)
- Dentinadhäsivsysteme (2)
- Dentinhaftvermittler (2)
- Dependenz (2)
- Depolarisation (2)
- Deregulierung (2)
- Derivation (2)
- Derivatisierung (2)
- Desertifikation (2)
- Desmoglein (2)
- DeuCze-Korpus (2)
- Deutsche Sprachwissenschaft (2)
- Deutsches Sprachgebiet (2)
- Deutschland (Bundesrepublik) (2)
- Deutschland / Stammzellgesetz (2)
- Dezentrale Regelung (2)
- Dezentralisierung (2)
- Diabetes mellitus Typ 2 (2)
- Diabetic polyneuropathy (2)
- Diagnosesystem (2)
- Diagnostic medicine (2)
- Dialekt (2)
- Dialektologie (2)
- Dialysepatienten (2)
- Dialysis (2)
- Diamiktit (2)
- Diborabenzol (2)
- Diboran (2)
- Diboret (2)
- Diborierung (2)
- Dichtegewichtung (2)
- Dickenmessung (2)
- Diels-Alder-Reaktion (2)
- Diethylstilbestrol (2)
- Difenidol (2)
- Differential effects of stressors (2)
- Differenziertes Schilddrüsenkarzinom (2)
- Differenzierungspotential (2)
- Diffusion Tensor Imaging (2)
- Diffusion coefficient (2)
- Diffusionsgewichtete Magnetresonanztomografie (2)
- Digital Elevation Model (2)
- Digital Religions Education (2)
- Digitale Signalverarbeitung (2)
- Digitalization (2)
- Dihydroborane (2)
- Dihydrooxazole (2)
- Dilatative Kardiomyopathie (2)
- Dioncophyllaceae (2)
- Diphosphonate (2)
- Direkte Demokratie (2)
- Dirichlet-Reihe (2)
- Disease (2)
- Diseases (2)
- Diskriminanzanalyse (2)
- Diskriminierung (2)
- Diskursmarker (2)
- Disney (2)
- Dispergierung (2)
- Distress (2)
- Distributed computing (2)
- Disulfidbrücken (2)
- Djebar, Assia (2)
- Dobutamin-Stressechokardiographie (2)
- Docking <Chemie> (2)
- Dodecaborane (2)
- Dominanz (2)
- Domäne (2)
- Donator <Chemie> (2)
- Dopaminerge Nervenzelle (2)
- Dopaminrezeptor (2)
- Dopaminstoffwechsel (2)
- Dopamintransporter (2)
- Doppelbesteuerung (2)
- Doppelkronen (2)
- Doppelverbeitragung (2)
- Dorsal Root Ganglion (2)
- Dorsal root ganglion (2)
- Dose response (2)
- Dose-response relationship (2)
- Dosimetry (2)
- Dosisreduktion (2)
- Dot-Depth Problem (2)
- Down-Syndrom (2)
- Dreidimensionale Bildverarbeitung (2)
- Dreidimensionales Bild (2)
- Dreidimensionales Modell (2)
- Dreifachbindung (2)
- Drogen (2)
- Drug design (2)
- Drug development (2)
- Drylands (2)
- Dsg2 (2)
- Dual-Source-Computertomographie (2)
- Duchenne (2)
- Duodenopankreatektomie (2)
- Durchblutungsmessung (2)
- Dwyka (2)
- Dyade (2)
- Dyes (2)
- Dystonia (2)
- Dämpfung (2)
- Dämpfungseigenschaften (2)
- Dünen (2)
- Dünndarmmotilität (2)
- Dünndarmtransplantat (2)
- E-Commerce (2)
- E-Government (2)
- E-learning (2)
- E. coli (2)
- E. coli Nissle (2)
- E. coli serotype 06 (2)
- EAA (2)
- EAAC1 (2)
- EBRA (2)
- ECMO-Therapie (2)
- EDA-NOCV (2)
- EEA (2)
- EF (2)
- EF-1A (2)
- EGF-Rezeptor (2)
- EGF-receptor (2)
- EGFP (2)
- EORTC (2)
- ERI (2)
- ERK signaling (2)
- ERT (2)
- ETiCS (2)
- EU (2)
- EUROASPIRE (2)
- EW (2)
- EXKK (2)
- EZH2 (2)
- Early Basso Continuo (2)
- Early Music (2)
- Early Neolithic (2)
- Early-onset (2)
- Earnings Quality (2)
- Echinococcosis (2)
- Ecological Momentary Assessment (2)
- Edelmetall (2)
- Edition (2)
- Efavirenz (2)
- Effektive Theorie (2)
- Effizienter Algorithmus (2)
- Effizienzsteigerung (2)
- Effluxpumpen (2)
- Ehrenamt (2)
- Eierstocktumor (2)
- Eindringerkennung (2)
- Einführung (2)
- Eingeweidewürmer (2)
- Einkauf (2)
- Einmodenlaser (2)
- Einsamkeit (2)
- Einsatzfahrten (2)
- Einsilbersprachverständnistest (2)
- Einwanderung (2)
- Einzelphotonenquelle (2)
- Eiparasitismus (2)
- Eisenoxid-Nanopartikel (2)
- Ekel (2)
- Elderly (2)
- Electroencephalography (2)
- Electromagnon (2)
- Electron Transfer (2)
- Electronic commerce (2)
- Electronic spectroscopy (2)
- Elektrische Leitfähigkeit (2)
- Elektrizitätsverbrauch (2)
- Elektroakupunktur (2)
- Elektroimpedanztomographie (2)
- Elektromagnon (2)
- Elektromobilität (2)
- Elektron-Elektron-Streuung (2)
- Elektronendichteverteilung (2)
- Elektronenflüssigkeit (2)
- Elektronenstrahllithographie (2)
- Elektronenzustand (2)
- Elektronische Anregung (2)
- Elektronische Spektroskopie (2)
- Elektronisches Publizieren (2)
- Elektrophysiologische Untersuchung (2)
- Elektrospinning (2)
- Elektrostimulation (2)
- Elementarteilchen (2)
- Elfenbeinküste (2)
- Elite Controller (2)
- Elmex (2)
- Elternarbeit (2)
- Elterntraining (2)
- Embolisation (2)
- Emotion regulation (2)
- Emotional processing (2)
- Empathie (2)
- Empirical Analysis (2)
- Empirische Forschung (2)
- Emulsion (2)
- Enantiomere (2)
- Enantiomerentrennung (2)
- Enantioselectivity (2)
- Encephalopathia hepatica (2)
- End-of-Life Care (2)
- End-zu-End-Anastomose (2)
- Endocannabinoide (2)
- Endocytosis (2)
- Endodermis (2)
- Endophytische Pilze (2)
- Endophänotyp (2)
- Endoplasmatisches Retikulum (2)
- Endoribonuklease P (2)
- Endoskopie (2)
- Endosom (2)
- Endosonographie (2)
- Endothelial cells (2)
- Endothelial dysfunction (2)
- Endothelin (2)
- Endotracheale Intubation (2)
- Energie (2)
- Energierecht (2)
- Energiereiches Teilchen (2)
- Energiespeicher (2)
- Energiestoffwechsel (2)
- Engadin (2)
- England (2)
- Englischunterricht (2)
- Enol Iactones (2)
- Enoxaparin (2)
- Enoyl-ACP-Reduktase (2)
- Enoyl-acyl-carrier-protein-Reductase (2)
- Entamoeba histolytica (2)
- Entanglement (2)
- Enterococcus faecium (2)
- Enterprise-Resource-Planning (2)
- Entropie (2)
- Entscheidbarkeit (2)
- Entscheidungen (2)
- Entscheidungsneutralität (2)
- Entscheidungsprozess (2)
- Entscheidungssammlung (2)
- Entscheidungsverhalten (2)
- Entstehungsgeschichte (2)
- Entzündungsparameter (2)
- Entzündungsreaktion (2)
- Entzündungsschmerz (2)
- Epidemiology (2)
- Epigenese (2)
- Epik (2)
- Epiphyten (2)
- Epitaxieschicht (2)
- Epithelial-mesenchymale Transition (2)
- Epithelkörperchen (2)
- Epithelzelle (2)
- Epitop (2)
- Epitope (2)
- Epitranscriptomics (2)
- Eplerenone (2)
- Epoxidation (2)
- Epoxidierung (2)
- Epstein-Barr-Virus (2)
- Erbrecht (2)
- Erdbeere (2)
- Erdbeobachtung (2)
- Erfahrungsverankerte Rezeption (2)
- Ergebnisse (2)
- Ergänzung (2)
- Erinnerung (2)
- Erk (2)
- Erlotinib (2)
- Erneuerbare-Energien-Gesetz (2)
- Ernteertrag (2)
- Ernährungstherapie (2)
- Ersatzstoff (2)
- Erwachsenenalter (2)
- Erysiphe graminis (2)
- Erythropoetin (2)
- Erythrozyten (2)
- Eschatologie (2)
- Eschatology (2)
- Escherichia coli K1 (2)
- Eskalation (2)
- Essstörung (2)
- Esterasen (2)
- Estimation (2)
- Estrogen (2)
- Etacrynsäure (2)
- Ethernet (2)
- Ethnizität (2)
- Ethnographie (2)
- Ethnologie (2)
- Etrusker (2)
- EuGH (2)
- Eukaryoten (2)
- Euphronios (2)
- European Central Bank (2)
- European Organization for Nuclear Research. ATLAS Collaboration (2)
- Europäische Aktiengesellschaft (2)
- Europäische Integration (2)
- Europäisches Arzneibuch (2)
- Euthanasie (2)
- Event-related potentials (2)
- Everolimus (2)
- Evolutionspsychologie (2)
- Evolutionärer Algorithmus (2)
- Ewing-Sarkom (2)
- Exacerbation (2)
- Examensklausur (2)
- Exciton coupling (2)
- Exegese (2)
- Exercise capacity (2)
- Exercise testing (2)
- Exomsequenzierung (2)
- Exosom <Vesikel> (2)
- Exotics (2)
- Expansion (2)
- Expansionsmikroskopie (2)
- Experiment (2)
- Experimental autoimmune encephalomyelitis (2)
- Experimental physics (2)
- Experteninterviews (2)
- Expertensystem (2)
- Expertise (2)
- Explainable AI (2)
- Explainable Artificial Intelligence (2)
- Explorative Datenanalyse (2)
- Explosion (2)
- Export (2)
- Expressionsanalyse (2)
- Extended Reality (2)
- Extensions of gauge sector (2)
- Extracellular Vesicles (2)
- Extracellular matrix (2)
- Extracorporeal Membrane Oxygenation (2)
- Extrakorporale Dialyse (2)
- Extrakorporale Membranoxygenierung (2)
- Extraterrestrische Forschung (2)
- Extraversion (2)
- Extrazellulärmatrix (2)
- Extreme Value Theory (2)
- Extremereignisse (2)
- Extremwert (2)
- Exziton-Exziton-Annihilierung (2)
- Exzitotoxizität (2)
- Eye-Tracking (2)
- Eyelid (2)
- Ezetimib (2)
- F-actin (2)
- F8 fimbriae (2)
- FAAH (2)
- FAS (2)
- FCS (2)
- FDG PET/CT (2)
- FDG-PET/CT (2)
- FFPE (2)
- FGF-pathway (2)
- FGFR1 (2)
- FIB-4 (2)
- FKBP52 (2)
- FOSL1 (2)
- FRET sensors (2)
- FTIR spectroscopy (2)
- Fabry genotype (2)
- Fabry nephropathy (2)
- Fabry phenotype (2)
- Fachsprache (2)
- Factor receptor (2)
- Fagus sylvatica (2)
- Fahrertraining (2)
- Fahrradergometer (2)
- Falle (2)
- Fallsammlung (2)
- Familienuntersuchung (2)
- Family-Investigation (2)
- FarR (2)
- Farbensehen (2)
- Farbwahrnehmung (2)
- FasL (2)
- Faser (2)
- Fatty acids (2)
- Fbw7 (2)
- Fc-receptor (2)
- FcγR (2)
- Fear conditioning (2)
- Feedback (2)
- Fehlertoleranz (2)
- Fehlerverarbeitung (2)
- Fehlstellung (2)
- Feldforschung (2)
- Feldstärkemessung (2)
- Feldtheorie (2)
- Female (2)
- Femtochemistry (2)
- Fermentation (2)
- Fernsehmaske (2)
- Fernwartung (2)
- Ferroelektrikum (2)
- Ferromagnete (2)
- Ferromagnetikum (2)
- Ferromagnetische Halbleiter (2)
- Ferromagnetismus (2)
- Ferroptosis (2)
- Fersenbeinbruch (2)
- Festkörper (2)
- Festkörper-NMR (2)
- Fett (2)
- Fettgewebsstammzellen (2)
- Fettleibigkeit (2)
- Fettsäure (2)
- Fibrinogen (2)
- Fibromyalgia (2)
- Fibromyalgiesyndrom (2)
- Fibronectin (2)
- Ficaria calthifolia (2)
- Ficaria verna (2)
- Fieber (2)
- Field programmable gate array (2)
- Figur (2)
- Figurenrede (2)
- Fingerprint-Verfahren (2)
- Fish (2)
- Fixateur interne (2)
- Flagelle (2)
- Flagellen (2)
- Flagelline (2)
- Flash-Speicher (2)
- Flavonoids (2)
- Flexibilität (2)
- Fließeigenschaften (2)
- Flow cytometry (2)
- Fluconazol (2)
- Fluconazole (2)
- Fluency (2)
- Flugkörper (2)
- Flugzeitmassenspektrometrie (2)
- Fluid-Feststoff-System (2)
- Fluktuation (2)
- Fluorchinolone (2)
- Fluorescence in situ hybridization (2)
- Fluorescence microscopy (2)
- Fluoreszenzaktivierter Zellsortierer (2)
- Fluoreszenzlöschung (2)
- Fluoreszenzmarkierung (2)
- Fluoreszenzsonde (2)
- Fluoreszenzspektrometer (2)
- Fluorierung (2)
- Fluoxetine (2)
- Flussufer (2)
- Flächenbedarf (2)
- Flüchtlingskrise (2)
- Flüssiger Zustand (2)
- Flüssigkristalle (2)
- Foamy virus (2)
- Fokker–Planck equation (2)
- Foldamere (2)
- Formaldehyd (2)
- Formation Flight (2)
- Formulation development (2)
- Forschungsparadigma (2)
- Fossil (2)
- FoxO3 (2)
- Fractalkin (2)
- Framework <Informatik> (2)
- Framework for Information Literacy for Higher Education (2)
- France (2)
- Frankfurter Allgemeine (2)
- Franz (2)
- Frauen (2)
- Freedom House (2)
- Freies Molekül (2)
- Freizügigkeit (2)
- Frequency (2)
- Frequency Domain (2)
- Frequenzanalyse (2)
- Freud (2)
- Friedreich-Ataxie (2)
- Front National (2)
- Frucht (2)
- Frustrated Lewis Pairs (2)
- Frustration (2)
- Frömmigkeit (2)
- Frühe akustisch evozierte Potentiale FAEP (2)
- Frühförderung (2)
- Frühjahr-Sommer-Encephalitis (2)
- Frühphase (2)
- Fullerenderivate (2)
- Fumonisine (2)
- Functional analyses (2)
- Fundoplikatio (2)
- Funktionelle Bildgebung (2)
- Funktionelle Kernspintomographie (2)
- Funktionelle Störung (2)
- Funktionentheorie (2)
- Funktionstest (2)
- Furan (2)
- Furanderivate (2)
- Furaneol (2)
- Furylborane (2)
- Fusion proteins (2)
- Fusobacterium nucleatum (2)
- Future Internet (2)
- Fußballverein (2)
- Fähigkeit (2)
- Förderschule (2)
- Förderschwerpunkt geistige Entwicklung (2)
- Förster Resonance Energy Transfer (2)
- Förster Resonanz Energie Transfer (2)
- Führung (2)
- G Protein (2)
- G protein coupled receptor (2)
- G protein-coupled receptor (2)
- G-Protein-gekoppelte Rezeptoren (2)
- G-Protein-gekoppelter Rezeptor (2)
- G-protein coupled receptor (2)
- G-protein coupled receptors (2)
- G-protein-coupled receptor (2)
- G-quadruplexes (2)
- GABA-Rezeptor (2)
- GABP (2)
- GAD1 (2)
- GAD65 (2)
- GAP (2)
- GATA-3 (2)
- GEF (2)
- GERD (2)
- GIRK (2)
- GLAST (2)
- GLP-1 (2)
- GLT1 (2)
- GLUT1 (2)
- GLUT2 (2)
- GLV-1H68 (2)
- GLaD-Studie (2)
- GLaD-study (2)
- GPS (2)
- GRAPPA (2)
- GRP78 (2)
- GSK3 (2)
- GTP-bindende Proteine (2)
- GUT (2)
- GaMnAs (2)
- Gadolinium (2)
- Galaxienentwicklung (2)
- Galaxienhaufen (2)
- Galeruca tanaceti (2)
- Galle (2)
- Galliumantimonid (2)
- Galliumnitrid (2)
- Galois-Theorie (2)
- Galvanische Abscheidung (2)
- Gamet (2)
- Gametogenese (2)
- Gamma (2)
- Gamma-Konvergenz (2)
- Ganganalyse (2)
- Ganzkörperbestrahlung (2)
- Gas (2)
- Gas chromatography (2)
- Gastroenterologische Endoskopie (2)
- Gastroschisis (2)
- Gastroösophageale Refluxkrankheit (2)
- Gastroösophagealer Reflux (2)
- Gastrulation (2)
- Gauge/Gravity Duality (2)
- Gaumen (2)
- Gaumenplatte (2)
- Gaumenspalte (2)
- Gedächtnisentwicklung (2)
- Gedächtniszellen (2)
- Gefahrenabwehr (2)
- Gefitinib (2)
- Gefrierstrukturierung (2)
- Gefäßchirurgie (2)
- Gefäßverschluss (2)
- Gefäßwand (2)
- Gefüge (2)
- Gegenwartssprache (2)
- Geistiges Eigentum (2)
- Geld (2)
- Geldtheorie (2)
- Gelelektrophorese (2)
- Gelenkpositionierung (2)
- Gemeinnützigkeit (2)
- Gemeinschaftsunterkunft (2)
- Gemeinschaftsökologie (2)
- Gen BRCA 1 (2)
- Gender studies (2)
- Gene Regulation (2)
- Gene cloning (2)
- Gene duplication (2)
- Generalized Nash Equilibrium Problem (2)
- Genes (2)
- Genetic instability (2)
- Genetics research (2)
- Genitiv (2)
- Genklonierung (2)
- Genomik (2)
- Genomvariabilität (2)
- Gentechnologie (2)
- Geophysics (2)
- Geriatrics (2)
- Gerichtete Erstarrung (2)
- Gerichtshof (2)
- Geringverdiener (2)
- German Hepatitis C-Registry (2)
- German people (2)
- Germanistik (2)
- Geschichte 1100-1600 (2)
- Geschichte 1605-1687 (2)
- Geschichte 1900-2000 (2)
- Geschichte 1919-1945 (2)
- Geschichte 2014 (2)
- Geschichte der Zahnheilkunde (2)
- Geschlechtsdifferenzierung (2)
- Gesetzliche Krankenversicherung (2)
- Gestaltungsorientierte Bildungsforschung (2)
- Gesteinsbildung (2)
- Gesteinskunde (2)
- Gesundheit (2)
- Gewalttätigkeit (2)
- Geweberegeneration (2)
- Gewicht (2)
- Gewichtsabnahme (2)
- Gewürz (2)
- Glasfaserstift (2)
- Glatiramer acetate (2)
- Gleason score (2)
- Gleichberechtigung (2)
- Gleichverteilung (2)
- Gletscherschwankung (2)
- Gliederfüßer (2)
- Gliedergürtelmuskeldystrophie (2)
- Global Governance (2)
- Globale Optimierung (2)
- Globaler Süden (2)
- Glomeruli (2)
- Glucocorticoids (2)
- Glucose metabolism (2)
- Glucosetransporter (2)
- Gluino production (2)
- Glukokortikoide (2)
- Glutamate (2)
- Glycerin (2)
- Glycoengineering (2)
- Glykane (2)
- Glykolyse (2)
- Gold Nanoparticles (2)
- Golf von Akaba (2)
- Golgi apparatus (2)
- Golgi-Apparat (2)
- Gondwana (2)
- Gothenburg model (2)
- Gott <Motiv> (2)
- Graft versus host disease (2)
- Graft-versus-leukemia (2)
- Gram-negative Bakterien (2)
- Granulieren (2)
- Granulit (2)
- Granulozyt (2)
- Gravitation (2)
- Grenze (2)
- Grenzwert (2)
- Grimmelshausen, Hans Jakob Christoffel von / Simplizissimus (2)
- Group B Streptococcus (2)
- Growth-differentiation Factor 15 (2)
- Großbritannien (2)
- Grundrechte (2)
- Grundstücksübertragung (2)
- Grundsubstanz (2)
- Grundvorstellung (2)
- Grundwortschatz (2)
- Guanidiniocarbonylpyrrol (2)
- Guanylylcyclase (2)
- Guidelines (2)
- Guillain-Barre-Syndrome (2)
- Guinea-pig uterus (2)
- Gymnasium (2)
- Gyrasehemmer (2)
- H-1-NMR spectroscopy (2)
- H2O2 (2)
- HADS-D (2)
- HAE (2)
- HAND (2)
- HBV (2)
- HCC (2)
- HCM (2)
- HD (2)
- HDAC (2)
- HDBSCAN (2)
- HDGF (2)
- HEMT (2)
- HERV-K (2)
- HES (2)
- HFQ (2)
- HIF-1 (2)
- HIF-1α (2)
- HIV-Demenz (2)
- HIV-Infection (2)
- HIV-infection (2)
- HIVDR (2)
- HKT transporter (2)
- HLA-E (2)
- HMG (2)
- HPA axis (2)
- HPK1 (2)
- HPLC-CD-Kopplung (2)
- HPP (2)
- HPV (2)
- HRQOL (2)
- HRXRD (2)
- HSC (2)
- HSM-sentence test (2)
- HSM-test (2)
- HSP90 inhibitor (2)
- HT-29 (2)
- HaCaT (2)
- Habitat (2)
- Habitat fragmentation (2)
- Haemostasis (2)
Institute
- Theodor-Boveri-Institut für Biowissenschaften (2306)
- Graduate School of Life Sciences (1034)
- Physikalisches Institut (811)
- Institut für Anorganische Chemie (678)
- Medizinische Klinik und Poliklinik I (667)
- Institut für Psychologie (604)
- Medizinische Klinik und Poliklinik II (579)
- Institut für Organische Chemie (562)
- Neurologische Klinik und Poliklinik (527)
- Klinik und Poliklinik für Allgemein-, Viszeral-, Gefäß- und Kinderchirurgie (Chirurgische Klinik I) (508)
Schriftenreihe
- Cultural Animal Studies, Band 3 (24)
- Spezielle Didaktik der Sportarten (2)
- Aesthetische Eigenzeiten, 17 (1)
- Akten des ... Symposiums des Mediävistenverbandes; 13,2 (1)
- Alter Orient und Altes Testament : Sonderreihe Veröffentlichungen zur Kultur und Geschichte des Alten Orients ; 3 (1)
- Aventiuren; 13 (1)
- Berichte aus der Informatik (1)
- Deuterocanonical and Cognate Literature Studies (1)
- Deuterocanonical and Cognate Literature Yearbook (1)
- Epistemata. Reihe Literaturwissenschaft ; 483 (1)
Sonstige beteiligte Institutionen
- VolkswagenStiftung (24)
- Johns Hopkins School of Medicine (18)
- Fraunhofer-Institut für Silicatforschung ISC (8)
- Helmholtz Institute for RNA-based Infection Research (HIRI) (7)
- IZKF Nachwuchsgruppe Geweberegeneration für muskuloskelettale Erkrankungen (7)
- Akademie der Wissenschaften und der Literatur, Mainz (6)
- DFG Forschungsgruppe 2757 / Lokale Selbstregelungen im Kontext schwacher Staatlichkeit in Antike und Moderne (LoSAM) (6)
- Clinical Trial Center (CTC) / Zentrale für Klinische Studien Würzburg (ZKSW) (5)
- Johns Hopkins University School of Medicine (5)
- Universität Leipzig (5)
ResearcherID
- B-1911-2015 (1)
- B-4606-2017 (1)
- C-2593-2016 (1)
- D-1221-2009 (1)
- D-1250-2010 (1)
- D-3057-2014 (1)
- I-5818-2014 (1)
- J-8841-2015 (1)
- M-1240-2017 (1)
- N-2030-2015 (1)
That the human brain contains magnetite is well established; however, its spatial distribution in the brain has remained unknown. We present room temperature, remanent magnetization measurements on 822 specimens from seven dissected whole human brains in order to systematically map concentrations of magnetic remanence carriers. Median saturation remanent magnetizations from the cerebellum were approximately twice as high as those from the cerebral cortex in all seven cases (statistically significantly distinct, p = 0.016). Brain stems were over two times higher in magnetization on average than the cerebral cortex. The ventral (lowermost) horizontal layer of the cerebral cortex was consistently more magnetic than the average cerebral cortex in each of the seven studied cases. Although exceptions existed, the reproducible magnetization patterns lead us to conclude that magnetite is preferentially partitioned in the human brain, specifically in the cerebellum and brain stem.
B cell development in bone marrow is a precisely regulated complex process. Through successive stages of differentiation, which are regulated by a multitude of signaling pathways and an array of lineage-specific transcription factors, the common lymphoid progenitors ultimately give rise to mature B cells. Similar to early thymocyte development in the thymus, early B cell development in bone marrow is critically dependent on IL-7 signaling. During this IL-7-dependent stage of differentiation, several transcription factors, such as E2A, EBF1, and Pax5, among others, play indispensable roles in B lineage specification and maintenance. Although recent studies have implicated several other transcription factors in B cell development, the role of NFATc1 in early B cell developmental stages is not known. Here, using multiple gene-manipulated mouse models and applying various experimental methods, we show that NFATc1 activity is vital for early B cell differentiation. Lack of NFATc1 activity in pro-B cells suppresses EBF1 expression, impairs immunoglobulin gene rearrangement, and thereby preBCR formation, resulting in defective B cell development. Overall, deficiency in NFATc1 activity arrested the pro-B cell transition to the pre-B cell stage, leading to severe B cell lymphopenia. Our findings suggest that, along with other transcription factors, NFATc1 is a critical component of the signaling mechanism that facilitates early B cell differentiation.
The remarkable diversity of sex determination mechanisms known in fish may be fuelled by exceptionally high rates of sex chromosome turnovers or transitions. However, the evolutionary causes and genomic mechanisms underlying this variation and instability are yet to be understood. Here we report on an over 30-year evolutionary experiment in which we tested the genomic consequences of hybridisation and selection between two Xiphophorus fish species with different sex chromosome systems. We find that introgression and imposing selection for pigmentation phenotypes results in the retention of an unexpectedly large maternally derived genomic region. During the hybridisation process, the sex-determining region of the X chromosome from one parental species was translocated to an autosome in the hybrids leading to the evolution of a new sex chromosome. Our results highlight the complexity of factors contributing to patterns observed in hybrid genomes, and we experimentally demonstrate that hybridisation can catalyze rapid evolution of a new sex chromosome.
Die Arbeit befasst sich mit der Akademisierung und Professionalisierung der Zahnheilkunde, insbesondere der Zahnchirurgie, in Würzburg und Unterfranken im 19. Jahrhundert. Dies wurde insbesondere anhand des zahnchirurgischen Teils der Lehrchirurgischen Instrumentensammlung der Universität Würzburg bzw. des Juliusspitals erforscht. Der zahnchirurgische Teil der Instrumentensammlung war bisher noch nicht erforscht worden und besteht aktuell aus 34+1 Instrumenten, die für diese Arbeit komplett katalogisiert wurden. Für die Entwicklung der Instrumente im Verlauf des 19. Jahrhunderts wurde die Provenienz der Teilsammlung ergründet und diese in den Kontext der Akademisierungsbewegung des 19. Jahrhunderts eingeordnet.
Die Forschung wurde anhand der tatsächlich in der Praxis tätigen und nach und nach akademisch ausgebildeten Personen nachvollzogen. Hierzu wurden neben den Instrumenten als Quelle die Adressbücher der Stadt Würzburg und die Matrikel-, Personal- und Vorlesungsverzeichnisse der Universität Würzburg des gesamten 19. Jahrhunderts systematisch durchgearbeitet. Außerdem wurden Lehrbücher aus dem nichtakademischen zahnchirurigischen Bereich (Bader) mit denen aus dem sich beginnenden akademischen Bereich analysiert. Anhand dieser Forschungsarbeit konnte dargelegt werden, dass die Zahnchirurgie sich analog zur Chiurgie aus dem handwerklichen Bereich abgekoppelt und nach und nach auf verschiedenen Stufen akademisiert hat. Die Zahnchirurgie hat sich "von unten nach oben" durch das Bestreben nichtakademisch ausgebildeter Menschen akademisiert.
Colon carcinomas (CRC) are statistically among the most fatal cancer types and hence one of the top reasons for premature mortality in the developed world. CRC cells are characterized by high proliferation rates caused by deregulation of gene transcription of proto-oncogenes and general chromosomal instability. On macroscopic level, CRC cells show a strongly altered nutrient and energy metabolism.
This work presents research to understand general links between the metabolism and transcription alteration. Mainly focussing on glutamine dependency, shown in colon carcinoma cells and expression pathways of the pro-proliferation protein c-MYC.
Previous studies showed that a depletion of glutamine in the cultivation medium of colon carcinoma cell lines caused a proliferation arrest and a strong decrease of overall c-MYC levels. Re-addition of glutamine quickly replenished c-MYC levels through an unknown mechanism. Several proteins altering this regulation mechanism were identified and proposed as possible starting point for further in detail studies to unveil the precise biochemical pathway controlling c-MYC translation repression and reactivation in a rapid manner.
On a transcriptional level the formation of RNA:DNA hybrids, so called R-loops, was observed under glutamine depleted conditions. The introduction and overexpression of RNaseH1, a R-loop degrading enzyme, in combination with an ectopically expressed c-MYC variant, independent of cellular regulation mechanisms by deleting the regulatory 3’-UTR of the c-MYC gene, lead to a high rate of apoptotic cells in culture. Expression of a functionally inactive variant of RNaseH1 abolished this effect. This indicates a regulatory function of R-loops formed during glutamine starvation in the presence of c-MYC protein in a cell. Degradation of R-loops and high c-MYC levels in this stress condition had no imminent effect on the cell cycle progression is CRC cells but disturbed the nucleotide metabolism. Nucleotide triphosphates were strongly reduced in comparison to starving cells without R-loop degradation and proliferating cells.
This study proposes a model of a terminal cycle of transcription termination, unregulated initiation and elongation of transcription leading to a depletion of energy resources of cells. This could finally lead to high apoptosis of the cells. Sequencing experiments to determine a coinciding of termination sites and R-loop formation sides failed so far but show a starting point for further studies in this essential survival mechanism involving R-loop formation and c-MYC downregulation.
Over the years, hydrogels have been developed and used for a huge variety of different applications ranging from drug delivery devices to medical products. In this thesis, a poly(2-methyl-2-oxazoline) (POx) / poly(2-n-propyl-2-oxazine) (POzi) bioink was modified and analyzed for the use in biofabrication and targeted drug delivery. In addition, the protein fibrinogen (Fbg) was genetically modified for an increased stability towards plasmin degradation for its use as wound sealant.
In Chapter 1, a thermogelling, printable POx/POzi-based hydrogel was modified with furan and maleimide moieties in the hydrophilic polymer backbone facilitating post-printing maturation of the constructs via Diels-Alder chemistry. The modification enabled long-term stability of the hydrogel scaffolds in aqueous solutions which is necessary for applications in biofabrication or tissue engineering. Furthermore, we incorporated RGD-peptides into the hydrogel which led to cell adhesion and elongated morphology of fibroblast cells seeded on top of the scaffolds. Additional printing experiments demonstrate that the presented POx/POzi system is a promising platform for the use as a bioink in biofabrication.
Chapter 2 highlights the versatility of the POx/POzi hydrogels by adapting the system to a use in targeted drug delivery. We used a bioinspired approach for a bioorthogonal conjugation of insulin-like growth factor I (IGF-I) to the polymer using an omega-chain-end dibenzocyclooctyne (DBCO) modification and a matrix metalloprotease-sensitive peptide linker. This approach enabled a bioresponsive release of IGF-I from hydrogels as well as spatial control over the protein distribution in 3D printed constructs which makes the system a candidate for the use in personalized medicine.
Chapter 3 gives a general overview over the necessity of wound sealants and the current generations of fibrin sealants on the market including advantages and challenges. Furthermore, it highlights trends and potential new strategies to tackle current problems and broadens the toolbox for future generations of fibrin sealants.
Chapter 4 applies the concepts of recombinant protein expression and molecular engineering to a novel generation of fibrin sealants. In a proof-of-concept study, we developed a new recombinant fibrinogen (rFbg) expression protocol and a Fbg mutant that is less susceptible to plasmin degradation. Targeted lysine of plasmin cleavage sites in Fbg were exchanged with alanine or histidine in different parts of the molecule. The protein was recombinantly produced and restricted plasmin digest was analyzed using high resolution mass spectrometry. In addition to that, we developed a novel time resolved screening protocol for the detection of new potential plasmin cleavage sites for further amino acid exchanges in the fibrin sealant.
Kovalente Inhibition stellt einen effektiven Weg dar, die Verweildauer des Liganden innerhalb einer Bindetasche zu erhöhen. In dieser Arbeit wurden theoretische Methoden angewendet, um die Reaktivität und den nichtkovalenten Zustand vor der Reaktion zu modellieren. Im Rahmen einer Fallstudie zu Cathepsin K wurden nichtkovalente Modelle von kovalenten Inhibitoren generiert. Für verschiedene Komplexe aus Cathepsin K und einem kovalent gebundenem Liganden wurde der Zustand vor der Reaktion modelliert und dessen Stabilität im Rahmen einer klassischen MD-Simulation überprüft. Die Stabilität des Warheads in der Bindetasche hing hauptsächlich vom gewählten Protonierungszustand der katalytischen Aminosäuren ab. Für eine Reihe von Inhibitoren der ChlaDUB1 wurde ein Protokoll aus quantenmechanischen Rechnungen genutzt, um die Reaktivität verschiedener Warheads abzuschätzen. Die erhaltenen Aktivierungsenergien korrelierten mit experimentell bestimmten Raten zur Inaktivierung des Enzyms. Im Rahmen eines Wirkstoffdesign-Projektes zur Deubiquitinase USP28 wurden von unpublizierten Kristallstrukturen ausgehend erste Docking-Experimente durchgeführt. Es konnte gezeigt werden, dass ein literaturbekannter Inhibitor von USP28 mit einem Warhead so modifiziert werden kann, dass die reaktive Einheit in direkter Nachbarschaft zu einem Cystein positioniert wird. Für diese Warheads wurden ebenfalls quantenmechanische Rechnungen zur Bestimmung der Aktivierungsenergie durchgeführt. Um besser nachvollziehen zu können, warum bei einem Photoswitch-Inhibitor der Butyrylcholin-Esterase der cis-Zustand des Moleküls besser inhibiert als der trans-Zustand, wurde eine Docking-Studie des Zustandes vor der Reaktion durchgeführt. Es konnte ein qualitatives Modell aufgestellt werden, das zeigt, dass der trans-Zustand aufgrund seiner längeren Form mit wichtigen Aminosäuren am Eingang der Bindungstasche kollidiert.
This thesis investigates the charged moments and the symmetry-resolved
entanglement entropy in the context of the AdS3/CFT2 duality. In the
first part, I focus on the holographic U(1) Chern-Simons-Einstein gravity,
a toy model of AdS3/CFT2 with U(1) Kac-Moody symmetry. I
start with the vacuum background with a single entangling interval. I
show that, apart from a partition function in the grand canonical ensemble,
the charged moments can also be interpreted as the two-point
function of vertex operators on the replica surface. For the holographic
description, I propose a duality between the bulk U(1) Wilson line and
the boundary vertex operators. I verify this duality by deriving the
effective action for the Chern-Simons fields and comparing the result
with the vertex correlator. In the twist field approach, I show that the
charged moments are given by the correlation function of the charged
twist operators and the additional background operators. To solve the
correlation functions involved, I prove the factorization of the U(1) extended
conformal block into a U(1) block and a Virasoro block. The
general expression for the U(1) block is derived by directly summing
over the current descendant states, and the result shows that it takes
an identical form as the vertex correlators. This leads to the conclusion
that the disjoint Wilson lines compute the neutral U(1) block. The final
result for the symmetry-resolved entanglement entropy shows that
it is always charge-independent in this model. In the second part, I
study charged moments in higher spin holography, where the boundary
theory is a CFT with W3 symmetry. I define the notion of the
higher spin charged moments by introducing a spin-3 modular charge
operator. Restricting to the vacuum background with a single entangling
interval, I employ the grand canonical ensemble interpretation
and calculate the charged moments via the known higher spin black
hole solution. On the CFT side, I perform a perturbative expansion for
the higher spin charged moments in terms of the connected correlation
functions of the spin-3 modular charge operators. Using the recursion
relation for the correlation functions of the W3 currents, I evaluate the
charged moments up to the quartic order of the chemical potential. The
final expression matches with the holographic result. My results both
for U(1) Chern-Simons Einstein gravity and W3 higher spin gravity
constitute novel checks of the AdS3/CFT2 correspondence.
Interactions between host and pathogen determine the development, progression and outcomes
of disease. Medicine benefits from better descriptions of these interactions through increased
precision of prevention, diagnosis and treatment of diseases. Single-cell genomics is a
disruptive technology revolutionizing science by increasing the resolution with which we study
diseases. Cell type specific changes in abundance or gene expression are now routinely investigated
in diseases. Meanwhile, detecting cellular phenotypes across diseases can connect
scientific fields and fuel discovery. Insights acquired through systematic analysis of high resolution
data will soon be translated into clinical practice and improve decision making. Therefore,
the continued use of single-cell technologies and their application towards clinical samples will
improve molecular interpretation, patient stratification, and the prediction of outcomes.
In the past years, I was fortunate to participate in interdisciplinary research groups bridging
biology, clinical research and data science. I was able to contribute to diverse projects through
computational analysis and biological interpretation of sequencing data. Together, we were
able to discover cellular phenotypes that influence disease progression and outcomes as well
as the response to treatment. Here, I will present four studies that I have conducted in my PhD.
First, we performed a case study of relapse from cell-based immunotherapy in Multiple Myeloma.
We identified genomic deletion of the epitope as mechanism of immune escape and implicate
heterozygosity or monosomy of the genomic locus at baseline as a potential risk factor. Second,
we investigated the pathomechanisms of severe COVID-19 at the earliest stage of the COVID-
19 pandemic in Germany in March 2020. We discovered that profibrotic macrophages and
lung fibrosis can be caused by SARS-CoV-2 infection. Third, we used a mouse model of chronic
infection with Staphylococcus aureus that causes Osteomyelitis similar to the human disease.
We were able to identify dysregulated immunometabolism associated with the generation of
myeloid-derived suppressor cells (MDSC). Fourth, we investigated Salmonella infection of the
human small intestine in an in vitro model and describe features of pathogen invasion and host
response.
Overall, I have been able to successfully employ single-cell sequencing to discover important
aspects of diseases ranging from development to treatment and outcome. I analyzed samples
from the clinics, human donors, mouse models and organoid models to investigate different
aspects of diseases and managed to integrate data across sample types, technologies and
diseases. Based on successful studies, we increased our efforts to combine data from multiple
sources to build comprehensive references for the integration of large collections of clinical
samples. Our findings exemplify how single-cell sequencing can improve clinical research and
highlights the potential of mechanistic discoveries to drive precision medicine.
Die distale Radiusfraktur gehört zu den häufigsten Frakturen in Deutschland mit einem Inzidenzanstieg im Alter unter Betonung des weiblichen Geschlechts. Dabei zeigt sich ein zunehmender Trend in Richtung operative Versorgung, allen voran die Versorgung mittels winkelstabiler Plattensysteme. Instabile, distale Radiusfrakturen werden dabei vor geplanter operativer Versorgung im Rahmen der Initialbehandlung üblicherweise geschlossen reponiert und im Gipsverband retiniert. Ziel der vorliegenden monozentrischen, prospektiv randomisierten Studie mit zwei Studiengruppen war es herauszufinden, ob sich das Unterlassen der Reposition vor geplanter Operation nachteilig auf das Schmerzniveau in der präoperativen Phase auswirkt und ob sich durch die Dislokation Nachteile in Bezug auf den Nervus medianus im Sinne eines Traktionsschadens sowie bezüglich des klinisch-radiologischen Ausheilungsergebnisses zeigen.
Die Studie zeigte, dass das Schmerzempfinden während der präoperativen Gipsbehandlung unabhängig von einer vorherigen Reposition war. Für den primären Endpunkt an Tag 1 nach der Akutbehandlung konnte statistisch signifikante Nichtunterlegenheit der Gruppe ohne Reposition gegenüber der Gruppe mit Reposition nachgewiesen werden. Gleiches galt für Tag 2, sowohl für die absoluten Schmerzniveaus als auch für die Schmerzlinderung.
Das Unterlassen der Reposition hatte zudem keine nachteiligen Effekte auf den Nervus medianus.
Gleiches zeigte sich für das klinische und radiologische Ausheilungsergebnis. Für die funktionellen DASH- und Krimmer-Scores konnte ein Jahr postoperativ ebenfalls statistisch signifikante Nichtunterlegenheit der Gruppe ohne Reposition nachgewiesen werden.
Diese Erkenntnisse bestätigen die in der Literatur vorhandenen Ergebnisse verschiedener Studien dahingehend, dass das Unterlassen der Reposition keine nachteiligen Effekte auf das postoperative Outcome hat. Einige Studien verdeutlichen zudem, dass es nach Reposition, insbesondere bei Vorliegen gewisser Risiko- und Instabilitätsfaktoren, ohnehin zur sekundären Dislokation kommt, sodass die generelle Notwendigkeit der Reposition vor Gipsanlage sowohl vor einer operativen als auch vor einer konservativen Weiterbehandlung angezweifelt werden
muss.
African trypanosomes are unicellular parasites that cause nagana and sleeping sickness in livestock and man, respectively. The major pathogens for the animal disease include Trypanosoma vivax, T. congolense, and T. brucei brucei, whereas T. b. gambiense and T. b. rhodesiense are responsible for human infections. Given that the bloodstream form (BSF) of African trypanosomes is exclusively extracellular, its cell surface forms a critical boundary with the host environment. The cell surface of the BSF African trypanosomes is covered by a dense coat of immunogenic variant surface glycoproteins (VSGs). This surface protein acts as an impenetrable shield that protects the cells from host immune factors and is also involved in antibody clearance and antigenic variation, which collectively ensure that the parasite stays ahead of the host immune system. Gene expression in T. brucei is markedly different from other eukaryotes: most genes are transcribed as long polycistronic units, processed by trans-splicing a 39-nucleotide mini exon at the 5′ and polyadenylation at the 3′ ends of individual genes to generate the mature mRNA.
Therefore, gene expression in T. brucei is regulated post-transcriptionally, mainly by the action of RNA binding proteins (RBPs) and conserved elements in the 3′ untranslated regions (UTR) of transcripts. The expression of VSGs is highly regulated, and only a single VSG gene is expressed at a time from one of the ~15 subtelomeric domains termed bloodstream expression sites (BES). When cells are engineered to simultaneously express two VSGs, the total VSG mRNA do not exceed the wild type amounts. This suggests that a robust VSG mRNA balancing mechanism exists in T. brucei. The present study uses inducible and constitutive expression of ectopic VSG genes to show that the endogenous VSG mRNA is regulated only if the second VSG is properly targeted to the ER. Additionally, the endogenous VSG mRNA response is triggered when high amounts of the GFP reporter with a VSG 3′UTR is targeted to the ER. Further evidence that non-VSG ER import signals can efficiently target VSGs to the ER is presented. This study suggests that a robust trans-regulation of the VSG mRNA is elicited at the ER through a feedback loop to keep the VSG transcripts in check and avoid overshooting the secretory pathway capacity.
Further, it was shown that induction of expression of the T. vivax VSG ILDat1.2 in T. brucei causes a dual cell cycle arrest, with concomitant upregulation of the protein associated with differentiation (PAD1) expression. It could be shown that T. vivax VSG ILDat1.2 can only be sufficiently expressed in T. brucei after replacing its native GPI signal peptide with that of a T. brucei VSG. Taken together, these data indicate that inefficient VSG GPI anchoring and expression of low levels of the VSG protein can trigger differentiation from slender BSF to stumpy forms. However, a second T. vivax VSG, ILDat2.1, is not expressed in T. brucei even after similar modifications to its GPI signals. An X-ray crystallography approach was utilized to solve the N-terminal domain (NTD) structure of VSG ILDat1.2. This is first structure of a non-T. brucei VSG, and the first of a surface protein of T. vivax to be solved. VSG ILDat1.2 NTD maintains the three-helical bundle scaffold conserved in T. brucei surface proteins. However, it is likely that there are variations in the architecture of the membrane proximal region of the ILDat1.2 NTD and its CTD from T. brucei VSGs. The tractable T. brucei system is presented as a model that can be used to study surface proteins of related trypanosome species, thus creating avenues for further characterization of trypanosome surface coats.
Die von Friedhelm Brusniak und Ulrich Konrad betreute und angenommene Dissertation nimmt den Briefwechsel zwischen August Heinrich Hoffmann von Fallersleben und dem jüngeren Augsburger Kapellmeister und Komponisten Hans Michael Schletterer in den Jahren 1862 bis 1873 in den Blick und dokumentiert dabei Hoffmanns Einfluss auf den Entstehungsprozess der Vertonungen seiner Lieder, besonders seiner Kinderlieder. Die Arbeit beleuchtet zudem den Erfahrungsschatz, den sich der ‚Dichter-Sänger‘ Hoffmann von Fallersleben auch durch die Zusammenarbeit mit anderen Musikern seiner Zeit, vorrangig Ludwig Christian Erk (1807–1883) und Ernst Heinrich Leopold Richter (1805–1876), erworben hatte. Darüber hinaus werden in der Korrespondenz Themen des gesellschaftlichen und politischen Lebens, der privaten und beruflichen Situation beider wie auch Hoffmanns Rolle als väterlicher Berater Schletterers berührt. Die Arbeit darf als neuer substantieller Beitrag der Hoffmann-Forschung und der interdisziplinären Liedforschung angesehen werden, der insbesondere der Kinderliedforschung neue Impulse verleiht.
Among the defense strategies developed in microbes over millions of years, the innate adaptive CRISPR-Cas immune systems have spread across most of bacteria and archaea. The flexibility, simplicity, and specificity of CRISPR-Cas systems have laid the foundation for CRISPR-based genetic tools. Yet, the efficient administration of CRISPR-based tools demands rational designs to maximize the on-target efficiency and off-target specificity. Specifically, the selection of guide RNAs (gRNAs), which play a crucial role in the target recognition of CRISPR-Cas systems, is non-trivial. Despite the fact that the emerging machine learning techniques provide a solution to aid in gRNA design with prediction algorithms, design rules for many CRISPR-Cas systems are ill-defined, hindering their broader applications.
CRISPR interference (CRISPRi), an alternative gene silencing technique using a catalytically dead Cas protein to interfere with transcription, is a leading technique in bacteria for functional interrogation, pathway manipulation, and genome-wide screens. Although the application is promising, it also is hindered by under-investigated design rules. Therefore, in this work, I develop a state-of-art predictive machine learning model for guide silencing efficiency in bacteria leveraging the advantages of feature engineering, data integration, interpretable AI, and automated machine learning. I first systematically investigate the influential factors that attribute to the extent of depletion in multiple CRISPRi genome-wide essentiality screens in Escherichia coli and demonstrate the surprising dominant contribution of gene-specific effects, such as gene expression level. These observations allowed me to segregate the confounding gene-specific effects using a mixed-effect random forest (MERF) model to provide a better estimate of guide efficiency, together with the improvement led by integrating multiple screens. The MERF model outperformed existing tools in an independent high-throughput saturating screen. I next interpret the predictive model to extract the design rules for robust gene silencing, such as the preference for cytosine and disfavoring for guanine and thymine within and around the protospacer adjacent motif (PAM) sequence. I further incorporated the MERF model in a web-based tool that is freely accessible at www.ciao.helmholtz-hiri.de.
When comparing the MERF model with existing tools, the performance of the alternative gRNA design tool optimized for CRISPRi in eukaryotes when applied to bacteria was far from satisfying, questioning the robustness of prediction algorithms across organisms. In addition, the CRISPR-Cas systems exhibit diverse mechanisms albeit with some similarities. The captured predictive patterns from one dataset thereby are at risk of poor generalization when applied across organisms and CRISPR-Cas techniques. To fill the gap, the machine learning approach I present here for CRISPRi could serve as a blueprint for the effective development of prediction algorithms for specific organisms or CRISPR-Cas systems of interest. The explicit workflow includes three principle steps: 1) accommodating the feature set for the CRISPR-Cas system or technique; 2) optimizing a machine learning model using automated machine learning; 3) explaining the model using interpretable AI. To illustrate the applicability of the workflow and diversity of results when applied across different bacteria and CRISPR-Cas systems, I have applied this workflow to analyze three distinct CRISPR-Cas genome-wide screens. From the CRISPR base editor essentiality screen in E. coli, I have determined the PAM preference and sequence context in the editing window for efficient editing, such as A at the 2nd position of PAM, A/TT/TG downstream of PAM, and TC at the 4th to 5th position of gRNAs. From the CRISPR-Cas13a screen in E. coli, in addition to the strong correlation with the guide depletion, the target expression level is the strongest predictor in the model, supporting it as a main determinant of the activation of Cas13-induced immunity and better characterizing the CRISPR-Cas13 system. From the CRISPR-Cas12a screen in Klebsiella pneumoniae, I have extracted the design rules for robust antimicrobial activity across K. pneumoniae strains and provided a predictive algorithm for gRNA design, facilitating CRISPR-Cas12a as an alternative technique to tackle antibiotic resistance.
Overall, this thesis presents an accurate prediction algorithm for CRISPRi guide efficiency in bacteria, providing insights into the determinants of efficient silencing and guide designs. The systematic exploration has led to a robust machine learning approach for effective model development in other bacteria and CRISPR-Cas systems. Applying the approach in the analysis of independent CRISPR-Cas screens not only sheds light on the design rules but also the mechanisms of the CRISPR-Cas systems. Together, I demonstrate that applied machine learning paves the way to a deeper understanding and a broader application of CRISPR-Cas systems.
Cognition refers to the ability to of animals to acquire, process, store and use vital information from the environment. Cognitive processes are necessary to predict the future and reduce the uncertainty of the ever-changing environment. Classically, research on animal cognition focuses on decisive cognitive tests to determine the capacity of a species by the testing the ability of a few individuals. This approach views variability between these tested key individuals as unwanted noise and is thus often neglected. However, inter-individual variability provides important insights to behavioral plasticity, cognitive specialization and brain modularity. Honey bees Apis mellifera are a robust and traditional model for the study of learning, memory and cognition due to their impressive capabilities and rich behavioral repertoire. In this thesis I have applied a novel view on the learning abilities of honey bees by looking explicitly at individual differences in a variety of learning tasks. Are some individual bees consistently smarter than some of her sisters? If so, will a smart individual always perform good independent of the time, the context and the cognitive requirements or do bees show distinct isolated ‘cognitive modules’?
My thesis presents the first comprehensive investigation of consistent individual differences in the cognitive abilities of honey bees. To speak of an individual as behaving consistently, a crucial step is to test the individual multiple times to examine the repeatability of a behavior. I show that free-flying bees remain consistent in a visual discrimination task for three consecutive days. Successively, I explored individual consistency in cognitive proficiency across tasks involving different sensory modalities, contexts and cognitive requirements. I found that free-flying bees show a cognitive specialization between visual and olfactory learning but remained consistent across a simple discrimination task and a complex concept learning task. I wished to further explore individual consistency with respect to tasks of different cognitive complexity, a question that has never been tackled before in an insect. I thus performed a series of four experiments using either visual or olfactory stimuli and a different training context (free-flying and restrained) and tested bees in a discrimination task, reversal learning and negative patterning. Intriguingly, across all these experiments I evidenced the same results: The bees’ performances were consistent across the discrimination task and reversal learning and negative patterning respectively. No association was evidenced between reversal learning and negative patterning. After establishing the existence of consistent individual differences in the cognitive proficiency of honey bees I wished to determine factors which could underlie these differences. Since genetic components are known to underlie inter-individual variability in learning abilities, I studied the effects of genetics on consistency in cognitive proficiency by contrasting bees originating from either from a hive with a single patriline (low genetic diversity) or with multiple patrilines (high genetic diversity). These two groups of bees showed differences in the patterns of individually correlated performances, indicating a genetic component accounts for consistent cognitive individuality. Another major factor underlying variability in learning performances is the individual responsiveness to sucrose solution and to visual stimuli, as evidenced by many studies on restrained bees showing a positive correlation between responsiveness to task relevant stimuli and learning performances. I thus tested whether these relationships between sucrose/visual responsiveness and learning performances are applicable for free-flying bees. Free-flying bees were again subjected to reversal learning and negative patterning and subsequently tested in the laboratory for their responsiveness to sucrose and to light. There was no evidence of a positive relationship between sucrose/visual responsiveness and neither performances of free-flying bees in an elemental discrimination, reversal learning and negative patterning. These findings indicate that relationships established between responsiveness to task relevant stimuli and learning proficiency established in the laboratory with restrained bees might not hold true for a completely different behavioral context i.e. for free-flying bees in their natural environment.
These results show that the honey bee is an excellent insect model to study consistency in cognitive proficiency and to identify the underlying factors. I mainly discuss the results with respect to the question of brain modularity in insects and the adaptive significance of individuality in cognitive abilities for honey bee colonies. I also provide a proposition of research questions which tie in this theme of consistent cognitive proficiency and could provide fruitful areas for future research.
Evaluierung prognostischer und prädiktiver Biomarker beim neoadjuvant vorbehandelten Rektumkarzinom
(2024)
Fragestellung. Osteopontin (OPN) kann im Blut nachgewiesen werden und wird bei vielen Tumorentitäten exprimiert, wie auch der Tyrosinkinaserezeptor c-Met und sein Ligand, das Zytokin Hepatocyte Growth Factor (HGF). In der vorliegenden Arbeit untersuchten wir die prognostische und prädiktive Wertigkeit der Plasmakonzentrationen von OPN, c-Met und HGF bei Patienten mit lokal fortgeschrittenem Rektumkarzinom (LARC).
Methodik. Das Plasma von 63 Patienten mit LARC wurde untersucht. Die Blutentnahmen (EDTA-Plasma) erfolgten vor Therapiebeginn sowie im Verlauf. Die Plasmaspiegel von OPN, c-Met und HGF wurden mittels Enzyme-Linked Immunosorbent Assay analysiert. Die Konzentrationen wurden auf eine Korrelation mit den klinischen Parametern untersucht.
Ergebnisse. 68 Patienten wurden neoadjuvant mit einer Radiochemotherapie behandelt, 63 Blutproben wurden untersucht. Initial befanden sich nach UICC 14 Patienten in Stadium II, 47 in Stadium III und 7 in Stadium IV. Das mediane Follow-Up betrug 29,87 Monate. 20 der 68 Patienten (29,4 %) verstarben, 19 entwickelten Fernmetastasen. OPN korrelierte signifikant mit dem Überleben (p=0,001). OPN-Werte korrelierten mit dem pT-Stadium (R:0,445 p=0,018) und dem pUICC-Stadium (R:0,412 p=0,018), sowie mit dem Auftreten von Fernmetastasen (R:0,271 p=0,031). Eine Korrelation zwischen OPN und dem Therapieansprechen konnte gezeigt werden: pathologisch komplette Remission (pCR) (R:0,379 p=0,001), NAR-Score (R:0,373 p=0,015), TRG (R:0,380 p=0,020). Die logistische Regressionsanalyse ergab eine Prädiktivität OPNs für pCR (OR:0,990 p=0,009), NAR-Score (OR:1,008 p=0,007), TRG (OR:0,459 p=0,008). C-Met und HGF korrelierten nicht mit dem Überleben. Für c-Met und HGF ergab sich keine Korrelation zu initialen klinischen Daten und Therapieansprechen. Die logistische Regression ergab keinen prädiktiven Wert.
Schlussfolgerung. Die Plasmakonzentration von OPN besitzt prognostische und prädiktive Wertigkeit beim LARC. Die Konzentrationen von c-Met und HGF sind nicht prognostisch für das Überleben oder prädiktiv für das Therapieansprechen.
There is a great need for valuable ex vivo models that allow for assessment of cartilage repair strategies to reduce the high number of animal experiments. In this paper we present three studies with our novel ex vivo osteochondral culture platform. It consists of two separated media compartments for cartilage and bone, which better represents the in vivo situation and enables supply of factors pecific to the different needs of bone and cartilage. We investigated whether separation of the cartilage and bone compartments and/or culture media results in the maintenance of viability, structural and functional properties of cartilage tissue. Next, we valuated for how long we can preserve cartilage matrix stability of osteochondral explants during long-term culture over 84 days. Finally, we determined the optimal defect size that does not show spontaneous self-healing in this culture system. It was demonstrated that separated compartments for cartilage and bone in combination with tissue-specific medium allow for long-term culture of osteochondral explants while maintaining cartilage viability, atrix tissue content, structure and mechanical properties for at least 56 days. Furthermore, we could create critical size cartilage defects of different sizes in the model. The osteochondral model represents a valuable preclinical ex vivo tool for studying clinically relevant cartilage therapies, such as cartilage biomaterials, for their regenerative potential, for evaluation of drug and cell therapies, or to study mechanisms of cartilage regeneration. It will undoubtedly reduce the number of animals needed for in vivotesting.
Politische Bildung übt nicht nur einen großen Einfluss auf die zukünftige Konstellation des politischen Systems aus, sondern beeinflusst ebenfalls das soziale Miteinander prägend. Damit werden entscheidende Weichen für die Entwicklung der Gesellschaft, der Nation und des Staates gestellt. Im Zuge dieses Prozesses durchläuft jeder junge Bürger einen politischen Bildungsweg an Schulen. Die Vorgaben darüber, wie schulische politische Bildung auszusehen hat und welche Kompetenzen Schüler in diesem Zusammenhang erwerben sollen, geben die Kultus- bzw. Bildungsministerien in Curricula vor, verbindlich für alle Lehrer. Durch eine komparative Analyse der Curricula kann damit eindeutig die staatlich vorgegebene politische, gesellschaftliche und soziale Richtung festgestellt werden, die junge Menschen einschlagen sollen. Welche edukativen Ziele der politischen Bildung werden verfolgt? Was sollen Schüler lernen, um mit diesen Kompetenzen die Zukunft ihres Kollektivs zu gestalten? Wo liegen die Gemeinsamkeiten und Unterschiede zweier Staaten, in unserem Fall Deutschlands und Polens, im Hinblick auf die schulische politische Bildung? Beantwortet werden diese Fragestellungen durch das Anwenden zweier Methoden der qualitativen Sozialforschung, der komparativen Inhaltsanalyse, zum einen der strukturierenden zum anderen der induktiven. Davor erfolgt eine komparativ quantitative Untersuchung, die den Umfang der Unterrichtszeit in den Leitfächern für politische Bildung in allen Bundesländern und in Polen vergleicht, was einer empirischen Totalerhebung der komplex umfangreichen Daten entspricht. Die quantitativen Forschungsergebnisse zeigen deutliche Differenzen zwischen Deutschland und Polen, in einem der beiden Staaten wird signifikant mehr Zeit für politische Bildung im Leitfach dieser Disziplin investiert als im anderen. Anhand der qualitativen Daten ist zu erkennen, dass einerseits eine gemeinsame Grundbasis von Kompetenzen der politischen Bildung zwischen Deutschland und Polen besteht. Anderseits stechen in beiden Ländern eindeutige Unterschiede hervor, deren Ursprung zum einen historische Erfahrungen der Nationen und Staaten abbildet, zum anderen aktuell gegensätzliche politische Interessen untermauert.
SMART (Simple Modular Architecture Research Tool) is a web resource (https://smart.embl.de) for the identification and annotation of protein domains and the analysis of protein domain architectures. SMART version 9 contains manually curatedmodels formore than 1300 protein domains, with a topical set of 68 new models added since our last update article (1). All the new models are for diverse recombinase families and subfamilies and as a set they provide a comprehensive overview of mobile element recombinases namely transposase, integrase, relaxase, resolvase, cas1 casposase and Xer like cellular recombinase. Further updates include the synchronization of the underlying protein databases with UniProt (2), Ensembl (3) and STRING (4), greatly increasing the total number of annotated domains and other protein features available in architecture analysis mode. Furthermore, SMART's vector-based protein display engine has been extended and updated to use the latest web technologies and the domain architecture analysis components have been optimized to handle the increased number of protein features available.
Hintergrund
Ein neues Rahmenkonzept hat die flexible Ableitung und Nutzung von rheumatologischen Schulungsprogrammen für unterschiedliche Versorgungsbereiche ermöglicht. Auf dieser Grundlage wurde eine 5‑stündige Basisschulung für Patienten mit rheumatoider Arthritis (RA) entwickelt, es wurden rheumatologische Fachärzte und Psychologen trainiert, und dann wurde die Wirksamkeit nach dem Wirkmodell der Patientenschulung evaluiert.
Methoden
Mit dem Studiendesign einer extern randomisierten Wartekontrollgruppenstudie mit 3 Messzeitpunkten wurde geprüft, wie sich die 5‑stündige Basisschulung auf das Erkrankungs- und Behandlungswissen sowie auf die Gesundheitskompetenz von RA-Patienten (n = 249) auswirkt. Weitere Fragen betrafen Einstellungsparameter, Kommunikationskompetenz, Erkrankungsauswirkungen und die Zufriedenheit mit der Schulung. Die Auswertungen erfolgten auf Intention-to-treat-Basis mit Kovarianzanalysen für die Hauptzielgrößen unter Berücksichtigung des Ausgangswertes.
Ergebnisse
Die Analysen zeigen, dass die Basisschulung RA wirksam ist. Noch 3 Monate nach der Schulung verfügten die Schulungsteilnehmer über mehr Wissen und Gesundheitskompetenz als die Wartekontrollgruppe mit kleinem bis mittelgroßem Effekt (d = 0,37 bzw. 0,38). In den Nebenzielgrößen zeigten sich mit Ausnahme der Krankheitskommunikation keine weiteren Schulungseffekte.
Diskussion
Die Basisschulung bietet eine gute Grundlage, auf der weitere Interventionen zur Verbesserung von Einstellungs- und Erkrankungsparametern aufbauen können. Sie eignet sich damit als zentraler Baustein für die rheumatologische Versorgung auf verschiedenen Ebenen.
Interpreting gaze behavior is essential in evaluating interaction partners, yet the ‘semantics of gaze’ in dynamic interactions are still poorly understood. We aimed to comprehensively investigate effects of gaze behavior patterns in different conversation contexts, using a two-step, qualitative-quantitative procedure. Participants watched video clips of single persons listening to autobiographic narrations by another (invisible) person. The listener’s gaze behavior was manipulated in terms of gaze direction, frequency and direction of gaze shifts, and blink frequency; emotional context was manipulated through the valence of the narration (neutral/negative). In Experiment 1 (qualitative-exploratory), participants freely described which states and traits they attributed to the listener in each condition, allowing us to identify relevant aspects of person perception and to construct distinct rating scales that were implemented in Experiment 2 (quantitative-confirmatory). Results revealed systematic and differential meanings ascribed to the listener’s gaze behavior. For example, rapid blinking and fast gaze shifts were rated more negatively (e.g., restless and unnatural) than slower gaze behavior; downward gaze was evaluated more favorably (e.g., empathetic) than other gaze aversion types, especially in the emotionally negative context. Overall, our study contributes to a more systematic understanding of flexible gaze semantics in social interaction.
Background
Deregulated expression of MYC is a driver of colorectal carcinogenesis, suggesting that decreasing MYC expression may have significant therapeutic value. CIP2A is an oncogenic factor that regulates MYC expression. CIP2A is overexpressed in colorectal cancer (CRC), and its expression levels are an independent marker for long-term outcome of CRC. Previous studies suggested that CIP2A controls MYC protein expression on a post-transcriptional level.
Methods
To determine the mechanism by which CIP2A regulates MYC in CRC, we dissected MYC translation and stability dependent on CIP2A in CRC cell lines.
Results
Knockdown of CIP2A reduced MYC protein levels without influencing MYC stability in CRC cell lines. Interfering with proteasomal degradation of MYC by usage of FBXW7-deficient cells or treatment with the proteasome inhibitor MG132 did not rescue the effect of CIP2A depletion on MYC protein levels. Whereas CIP2A knockdown had marginal influence on global protein synthesis, we could demonstrate that, by using different reporter constructs and cells expressing MYC mRNA with or without flanking UTR, CIP2A regulates MYC translation. This interaction is mainly conducted by the MYC 5′UTR.
Conclusions
Thus, instead of targeting MYC protein stability as reported for other tissue types before, CIP2A specifically regulates MYC mRNA translation in CRC but has only slight effects on global mRNA translation. In conclusion, we propose as novel mechanism that CIP2A regulates MYC on a translational level rather than affecting MYC protein stability in CRC.
Formation and treatment of biofilms present a great challenge for health care and industry. About 80% of human infections are associated with biofilms including biomaterial centered infections, like infections of prosthetic heart valves, central venous catheters, or urinary catheters. Additionally, biofilms can cause food and drinking water contamination. Biofilm research focusses on application of experimental biofilm models to study initial adherence processes, to optimize physico-chemical properties of medical materials for reducing interactions between materials and bacteria, and to investigate biofilm treatment under controlled conditions. Exploring new antimicrobial strategies plays a key role in a variety of scientific disciplines, like medical material research, anti-infectious research, plant engineering, or wastewater treatment. Although a variety of biofilm models exist, there is a lack of standardization for experimental protocols, and designing experimental setups remains a challenge. In this study, a number of experimental parameters critical for material research have been tested that influence formation and stability of an experimental biofilm using the non-pathogenic model strain of Pseudomonas fluorescens. These parameters include experimental time frame, nutrient supply, inoculum concentration, static and dynamic cultivation conditions, material properties, and sample treatment during staining for visualization of the biofilm. It was shown, that all tested parameters critically influence the experimental biofilm formation process. The results obtained in this study shall support material researchers in designing experimental biofilm setups.
In this work, we present a multimodal approach to three-dimensionally quantify and visualize fiber orientation and resin-rich areas in carbon-fiber-reinforced polymers manufactured by vacuum infusion. Three complementary image modalities were acquired by Talbot–Lau grating interferometer (TLGI) X-ray microcomputed tomography (XCT). Compared to absorption contrast (AC), TLGI-XCT provides enhanced contrast between polymer matrix and carbon fibers at lower spatial resolutions in the form of differential phase contrast (DPC) and dark-field contrast (DFC). Consequently, relatively thin layers of resin, effectively indiscernible from image noise in AC data, are distinguishable. In addition to the assessment of fiber orientation, the combination of DPC and DFC facilitates the quantification of resin-rich areas, e.g., in gaps between fiber layers or at binder yarn collimation sites. We found that resin-rich areas between fiber layers are predominantly developed in regions characterized by a pronounced curvature. In contrast, in-layer resin-rich areas are mainly caused by the collimation of fibers by binder yarn. Furthermore, void volume around two adjacent 90°-oriented fiber layers is increased by roughly 20% compared to a random distribution over the whole specimen.
The article deals with the pedagogical content knowledge of mathematical modelling as part of the professional competence of pre-service teachers. With the help of a test developed for this purpose from a conceptual model, we examine whether this pedagogical content knowledge can be promoted in its different facets—especially knowledge about modelling tasks and about interventions—by suitable university seminars. For this purpose, the test was administered to three groups in a seminar for the teaching of mathematical modelling: (1) to those respondents who created their own modelling tasks for use with students, (2) to those trained to intervene in mathematical modelling processes, and (3) participating students who are not required to address mathematical modelling. The findings of the study—based on variance analysis—indicate that certain facets (knowledge of modelling tasks, modelling processes, and interventions) have increased significantly in both experimental groups but to varying degrees. By contrast, pre-service teachers in the control group demonstrated no significant change to their level of pedagogical content knowledge.
In 2020, cancer was the leading cause of death worldwide, accounting for nearly 10 million deaths. Lung cancer was the most common cancer, with 2.21 million cases per year in both sexes. This non-homogeneous disease is further subdivided into small cell lung cancer (SCLC, 15%) and non-small cell lung cancer (NSCLC, 85%). By 2023, the American Cancer Society estimates that NSCLC will account for 13% of all new cancer cases and 21% of all estimated cancer deaths. In recent years, the treatment of patients with NSCLC has improved with the development of new therapeutic interventions and the advent of targeted and personalised therapies. However, these advances have only marginally improved the five-year survival rate, which remains alarmingly low for patients with NSCLC. This observation highlights the importance of having more appropriate experimental and preclinical models to recapitulate, identify and test novel susceptibilities in NSCLC. In recent years, the Trp53fl/fl KRaslsl-G12D/wt mouse model developed by Tuveson, Jacks and Berns has been the main in vivo model used to study NSCLC. This model mimics ADC and SCC to a certain extent. However, it is limited in its ability to reflect the genetic complexity of NSCLC. In this work, we use CRISPR/Cas9 genome editing with targeted mutagenesis and gene deletions to recapitulate the conditional model. By comparing the Trp53fl/fl KRaslsl- G12D/wt with the CRISPR-mediated Trp53mut KRasG12D, we demonstrated that both showed no differences in histopathological features, morphology, and marker expression. Furthermore, next-generation sequencing revealed a very high similarity in their transcriptional profile. Adeno-associated virus-mediated tumour induction and the modular design of the viral vector allow us to introduce additional mutations in a timely manner. CRISPR-mediated mutation of commonly mutated tumour suppressors in NSCLC reliably recapitulated the phenotypes described in patients in the animal model. Lastly, the dual viral approach could induce the formation of lung tumours not only in constitutive Cas9 expressing animals, but also in wildtype animals. Thus, the implementation of CRISPR genome editing can rapidly advance the repertoire of in vivo models for NSCLC research. Furthermore, it can reduce the necessity of extensive breeding.
Optimization problems with composite functions consist of an objective function which is the sum of a smooth and a (convex) nonsmooth term. This particular structure is exploited by the class of proximal gradient methods and some of their generalizations like proximal Newton and quasi-Newton methods. The current literature on these classes of methods almost exclusively considers the case where also the smooth term is convex. Here we present a globalized proximal Newton-type method which allows the smooth term to be nonconvex. The method is shown to have nice global and local convergence properties, and some numerical results indicate that this method is very promising also from a practical point of view.
In der Dissertation „Zwei Burschenschafter als Bürgermeister im Dritten Reich. Theo Memmel in Würzburg und Paul May in Halle im Vergleich.“ steht die Untersuchung der Lebenswege der beiden Wahlbeamten Dr. Paul May und Theodor Memmel anhand ihrer Biographien im Fokus. May glitt dank seiner sich stetig erweiternden Fachkenntnisse sowie seiner Anpassungsfähigkeit durchweg in Leistungspositionen problemlos durch vier politische Systeme - vom Kaiserreich bis zur DDR. Seiner bürgerlichen politischen Ausrichtung blieb er hierbei stets treu. Memmel hingegen machte bedingt durch seine an-dere und gravierendere Weltkriegserfahrung einen Prozess vom politisch des-interessierten Front- und Freikorpskämpfer über die Bayerische Volkspartei hin zum überzeugten Nationalsozialisten. Nach dem Untergang des Dritten Reichs stand er vor dem Nichts, sowohl in beruflicher als auch in politischer Hinsicht. In seiner Studentenverbindung fand er jedoch einen Raum, in dem er sich engagieren und Anerkennung finden konnte.
Da May und Memmel durch ihre gemeinsame studentische Korporation gleich sozialisiert wurden und sie sich auf unterschiedliche Weise wie ein ro-ter Faden durch ihr Leben zog, erfuhr diese ebenfalls eine Untersuchung. Hierbei ergab sich, dass die Wandlung von der toleranten Progressverbindung Adelphia zur pflichtschlagenden Burschenschaft in der Deutschen Burschen-schaft im Jahr 1933 keinen plötzlichen Bruch darstellte, sondern vielmehr die Folge einer langjährigen Entwicklung war, wobei der Erste Weltkrieg als be-sonders einschneidender Faktor zu bewerten ist. Am letztendlichen Art- und Dachverbandswechsel hatte auch Memmel einen entscheidenden Anteil. Dass nach der Umwandlung der waffenstudentischen Verbindungen in NS-Kameradschaften diese (auch Adelphia) während des Zweiten Weltkriegs teil-weise in Würzburg im Verborgenen wiedererstehen konnten, hing auch mit der Patronage durch Memmel und sein imposantes Netzwerk zusammen.
Den dritten Untersuchungskomplex dieser Arbeit bildet die kommunale Entwicklung von Groß- und Gauhauptstädten im Dritten Reich, da sowohl Würzburg als auch Halle eine solche verkörperten. Ein Vergleich mit anderen Städten unter denselben Voraussetzungen lässt darauf schließen: Wer 1933/34 Oberbürgermeister einer Groß- und Gauhauptstadt wurde, verdank-te dies nicht seiner Qualifikation. Die Nationalsozialisten, die dieses Amt er-hielten, bemühten sich noch nicht einmal darum, es zu bekommen. Vielmehr stellten sie einen Kompromiss aus den jeweiligen lokalen Macht- und Interes-senskonstellationen dar. Eine Ausnahme hiervon bilden nur die wenigen Städte, in denen bereits vor 1933 ein NSDAP-Angehöriger als Stadtoberhaupt kandidiert hatte. Der Status der Gauhauptstadt führte für die jeweiligen Oberbürgermeister zu einem ganz besonderen Unterstellungsverhältnis, das sich als zweiseitiges Schwert entpuppte: Einerseits erhielt ihre Kommune spezielle Förderung, andererseits standen sie unter einem hohem Erwar-tungsdruck, der sich vielerorts in einem schlechten Verhältnis von Oberbür-germeister und Gauleiter manifestierte. Das Oberbürgermeisteramt im Drit-ten Reich stellte aus beruflicher Sicht einen doppelten Bruch mit der Zeit vor 1933 dar: Zum einen konnte man ohne die bis dahin üblichen Qualifikationen zum Wahlbeamten einer Großstadt aufsteigen, andererseits bedeutete dies auch gleichzeitig das Karriereende.
Abstract
To compare intravenous contrast material (CM) injection protocols for dual-energy CT pulmonary angiography (CTPA) in patients with suspected acute pulmonary embolism with regard to image quality and pulmonary perfused blood volume (PBV) values. A total of 198 studies performed with four CM injection protocols varying in CM volume and iodine delivery rates (IDR) were retrospectively included: (A) 60 ml at 5 ml/s (IDR = 1.75gI/s), (B) 50 ml at 5 ml/s (IDR = 1.75gI/s), (C) 50 ml at 4 ml/s (IDR = 1.40gI/s), (D) 40 ml at 3 ml/s (IDR = 1.05gI/s). Image quality and PBV values at different resolution settings were compared. Pulmonary arterial tract attenuation was highest for protocol A (397 ± 110 HU; p vs. B = 0.13; vs. C = 0.02; vs. D < 0.001). CTPA image quality of protocol A was rated superior compared to protocols B and D by reader 1 (p = 0.01; < 0.001), and superior to protocols B, C and D by reader 2 (p < 0.001; 0.02; < 0.001). Otherwise, there were no significant differences in CTPA quality ratings. Subjective iodine map ratings did not vary significantly between protocols A, B, and C. Both readers rated protocol D inferior to all other protocols (p < 0.05). PBV values did not vary significantly between protocols A and B at resolution settings of 1, 4 and 10 (p = 0.10; 0.10; 0.09), while otherwise PBV values displayed a decreasing trend from protocol A to D (p < 0.05). Higher CM volume and IDR are associated with superior CTPA and iodine map quality and higher absolute PBV values.
Purpose
Radiotherapy (RT) was identified as a risk factor for long-term cardiac effects in breast cancer patients treated until the 1990s. However, modern techniques reduce radiation exposure of the heart, but some exposure remains unavoidable. In a retrospective cohort study, we investigated cardiac mortality and morbidity of breast cancer survivors treated with recent RT in Germany.
Methods
A total of 11,982 breast cancer patients treated between 1998 and 2008 were included. A mortality follow-up was conducted until 06/2018. In order to assess cardiac morbidity occurring after breast cancer treatment, a questionnaire was sent out in 2014 and 2019. The effect of breast cancer laterality on cardiac mortality and morbidity was investigated as a proxy for radiation exposure. We used Cox Proportional Hazards regression analysis, taking potential confounders into account.
Results
After a median follow-up time of 11.1 years, there was no significant association of tumor laterality with cardiac mortality in irradiated patients (hazard ratio (HR) for left-sided versus right-sided tumor 1.09; 95% confidence interval (CI) 0.85–1.41). Furthermore, tumor laterality was not identified as a significant risk factor for cardiac morbidity (HR = 1.05; 95%CI 0.88–1.25).
Conclusions
Even though RT for left-sided breast cancer on average incurs higher radiation dose to the heart than RT for right-sided tumors, we found no evidence that laterality is a strong risk factor for cardiac disease after contemporary RT. However, larger sample sizes, longer follow-up, detailed information on individual risk factors and heart dose are needed to assess clinically manifest late effects of current cancer therapy.
Across Europe, calcareous grasslands become increasingly fragmented and their quality deteriorates through abandonment and land use intensification, both affecting biodiversity. Here, we investigated local and landscape effects on diversity patterns of several taxonomic groups in a landscape of highly fragmented calcareous grassland remnants. We surveyed 31 grassland fragments near Göttingen, Germany, in spring and summer 2017 for vascular plants, butterflies and birds, with sampling effort adapted to fragment area. Through regression modelling, we tested relationships between species richness and fragment size (from 314 to 51,395 m\(^2\)), successional stage, habitat connectivity and the per cent cover of arable land in the landscape at several radii. We detected 283 plant species, 53 butterfly species and 70 bird species. Of these, 59 plant species, 19 butterfly species and 9 bird species were grassland specialists. Larger fragments supported twice the species richness of plants than small ones, and hosted more species of butterflies, but not of birds. Larger grassland fragments contained more grassland specialist plants, but not butterfly or bird specialists. Increasing amounts of arable land in the landscape from 20 to 90% was related to the loss of a third of species of plants, and less so, of butterflies, but not of birds. Per cent cover of arable land negatively correlated to richness of grassland specialist plants and butterflies, but positively to grassland specialist birds. We found no effect by successional stages and habitat connectivity. Our multi-taxa approach highlights the need for conservation management at the local scale, complemented by measures at the landscape scale.
Physical regimes characterized by low Mach numbers and steep stratifications pose severe challenges to standard finite volume methods. We present three new methods specifically designed to navigate these challenges by being both low Mach compliant and well-balanced. These properties are crucial for numerical methods to efficiently and accurately compute solutions in the regimes considered.
First, we concentrate on the construction of an approximate Riemann solver within Godunov-type finite volume methods. A new relaxation system gives rise to a two-speed relaxation solver for the Euler equations with gravity. Derived from fundamental mathematical principles, this solver reduces the artificial dissipation in the subsonic regime and preserves hydrostatic equilibria. The solver is particularly stable as it satisfies a discrete entropy inequality, preserves positivity of density and internal energy, and suppresses checkerboard modes.
The second scheme is designed to solve the equations of ideal MHD and combines different approaches. In order to deal with low Mach numbers, it makes use of a low-dissipation version of the HLLD solver and a partially implicit time discretization to relax the CFL time step constraint. A Deviation Well-Balancing method is employed to preserve a priori known magnetohydrostatic equilibria and thereby reduces the magnitude of spatial discretization errors in strongly stratified setups.
The third scheme relies on an IMEX approach based on a splitting of the MHD equations. The slow scale part of the system is discretized by a time-explicit Godunov-type method, whereas the fast scale part is discretized implicitly by central finite differences. Numerical dissipation terms and CFL time step restriction of the method depend solely on the slow waves of the explicit part, making the method particularly suited for subsonic regimes. Deviation Well-Balancing ensures the preservation of a priori known magnetohydrostatic equilibria.
The three schemes are applied to various numerical experiments for the compressible Euler and ideal MHD equations, demonstrating their ability to accurately simulate flows in regimes with low Mach numbers and strong stratification even on coarse grids.
Based on an embodied account of language comprehension, this study investigated the dynamic characteristics of children and adults’ perceptual simulations during sentence comprehension, using a novel paradigm to assess the perceptual simulation of objects moving up and down a vertical axis. The participants comprised adults (N = 40) and 6-, 8-, and 10-year-old children (N = 116). After listening in experimental trials to sentences implying that objects moved upward or downward, the participants were shown pictures and had to decide as quickly as possible whether the objects depicted had been mentioned in the sentences. The target pictures moved either up or down and then stopped in the middle of the screen. All age groups’ reaction times were found to be shorter when the objects moved in the directions that the sentences implied. Age exerted no developmental effect on reaction times. The findings suggest that dynamic perceptual simulations are fundamental to language comprehension in text recipients aged 6 and older.
Coisotropic algebras consist of triples of algebras for which a reduction can be defined and unify in a very algebraic fashion coisotropic reduction in several settings. In this paper, we study the theory of (formal) deformation of coisotropic algebras showing that deformations are governed by suitable coisotropic DGLAs. We define a deformation functor and prove that it commutes with reduction. Finally, we study the obstructions to existence and uniqueness of coisotropic algebras and present some geometric examples.
Quantitative information is omnipresent in the world and a wide range of species has been shown to use quantities to optimize their decisions. While most studies have focused on vertebrates, a growing body of research demonstrates that also insects such as honeybees possess basic quantitative abilities that might aid them in finding profitable flower patches. However, it remains unclear if for insects, quantity is a salient feature relative to other stimulus dimensions, or if it is only used as a “last resort” strategy in case other stimulus dimensions are inconclusive. Here, we tested the stingless bee Trigona fuscipennis, a species representative of a vastly understudied group of tropical pollinators, in a quantity discrimination task. In four experiments, we trained wild, free-flying bees on stimuli that depicted either one or four elements. Subsequently, bees were confronted with a choice between stimuli that matched the training stimulus either in terms of quantity or another stimulus dimension. We found that bees were able to discriminate between the two quantities, but performance differed depending on which quantity was rewarded. Furthermore, quantity was more salient than was shape. However, quantity did not measurably influence the bees' decisions when contrasted with color or surface area. Our results demonstrate that just as honeybees, small-brained stingless bees also possess basic quantitative abilities. Moreover, invertebrate pollinators seem to utilize quantity not only as "last resort" but as a salient stimulus dimension. Our study contributes to the growing body of knowledge on quantitative cognition in invertebrate species and adds to our understanding of the evolution of numerical cognition.
Ende des 19. Jahrhunderts standen sich in Deutschland zwei verschiedene Arten psychiatrischer Institutionen gegenüber, die Anstaltspsychiatrien auf der einen, die universitären psychiatrischen Kliniken auf der anderen Seite. Die psychiatriehistorische Forschung widmete sich überwiegend psychiatrischen Anstalten während Kliniken hier unterrepräsentiert sind. Die vorliegende Arbeit möchte zur historischen Kenntnis universitärer psychiatrischer Einrichtungen beitragen. Hierzu werden die Charakteristika einer psychiatrischen Klinik um 1900 anhand des Beispiels der psychiatrischen Klinik der Universität Würzburg betrachtet. Der Fokus liegt hierbei neben Lage und Aufbau der Klinik sowie deren Personal auf den drei Bereichen Patient*innen, Forschung und Lehre.
Objectives
To determine sleep bruxism (SB) behavior during five consecutive nights and to identify correlations between SB episodes per hour (SB index) and sleep-time masseter-muscle activity (sMMA).
Material and methods
Thirty-one participants were included in the study. Of these, 10 were classified as sleep bruxers (group SB-1) and nine as non-sleep bruxers (group non-SB). The bruxism status of these 19 patients was identified by means of questionnaires, an assessment of clinical symptoms, and electromyographic/electrocardiographic data (Bruxoff® device). The remaining 12 participants were also identified as bruxers, but based exclusively on data from the Bruxoff device (group SB-2). Data analysis included descriptive statistics and Spearman’s correlation to assess the relationship between the SB index and sMMA.
Results
Participants in group SB-1 showed an overall mean SB index of 3.1 ± 1.6 and a mean total sMMA per night of 62.9 ± 38.3. Participants in group SB-2 had an overall mean SB index of 2.7 ± 1.5 and a mean total sMMA of 56.0 ± 29.3. In the non-SB group, participants showed an overall mean SB index of 0.8 ± 0.5 and a mean total sMMA of 56.8 ± 30.3. Spearman’s correlation yielded values of − 0.27 to 0.71 for the correlation between sMMA and SB index.
Conclusions
The data revealed variable SB activity and the absence of a reliable correlation between sMMA and the SB index.
Clinical relevance
The high variation in SB activity and lack of correlation between sMMA and the SB index should be considered when diagnosing SB.
Trial registration
Clinical Trials [NIH], clinical trial no. NCT03039985.
Objectives
Micro-computed tomography (μ-CT) and histology, the current gold standard methods for assessing the formation of new bone and blood vessels, are invasive and/or destructive. With that in mind, a more conservative tool, dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI), was tested for its accuracy and reproducibility in monitoring neovascularization during bone regeneration. Additionally, the suitability of blood perfusion as a surrogate of the efficacy of osteoplastic materials was evaluated.
Materials and methods
Sixteen rabbits were used and equally divided into four groups, according to the time of euthanasia (2, 3, 4, and 6 weeks after surgery). The animals were submitted to two 8-mm craniotomies that were filled with blood or autogenous bone. Neovascularization was assessed in vivo through DCE-MRI, and bone regeneration, ex vivo, through μ-CT and histology.
Results
The defects could be consistently identified, and their blood perfusion measured through DCE-MRI, there being statistically significant differences within the blood clot group between 3 and 6 weeks (p = 0.029), and between the former and autogenous bone at six weeks (p = 0.017). Nonetheless, no significant correlations between DCE-MRI findings on neovascularization and μ-CT (r =−0.101, 95% CI [−0.445; 0.268]) or histology (r = 0.305, 95% CI [−0.133; 0.644]) findings on bone regeneration were observed.
Conclusions
These results support the hypothesis that DCE-MRI can be used to monitor neovascularization but contradict the premise that it could predict bone regeneration as well.
Objectives
To investigate plaque inhibition of 0.1% octenidine mouthwash (OCT) vs. placebo over 5 days in the absence of mechanical plaque control.
Materials and methods
For this randomized, placebo-controlled, double-blind, parallel group, multi-center phase 3 study, 201 healthy adults were recruited. After baseline recording of plaque index (PI) and gingival index (GI), collection of salivary samples, and dental prophylaxis, subjects were randomly assigned to OCT or placebo mouthwash in a 3:1 ratio. Rinsing was performed twice daily for 30 s. Colony forming units in saliva were determined before and after the first rinse. At day 5, PI, GI, and tooth discoloration index (DI) were assessed. Non-parametric van Elteren tests were applied with a significance level of p < 0.05.
Results
Treatment with OCT inhibited plaque formation more than treatment with placebo (PI: 0.36 vs. 1.29; p < 0.0001). OCT reduced GI (0.04 vs. placebo 0.00; p = 0.003) and salivary bacterial counts (2.73 vs. placebo 0.24 lgCFU/ml; p < 0.0001). Tooth discoloration was slightly higher under OCT (DI: 0.25 vs. placebo 0.00; p = 0.0011). Mild tongue staining and dysgeusia occurred.
Conclusions
OCT 0.1% mouthwash inhibits plaque formation over 5 days. It therefore can be recommended when regular oral hygiene is temporarily compromised.
Clinical relevance
When individual plaque control is compromised, rinsing with octenidine mouthwash is recommended to maintain healthy oral conditions while side effects are limited.
The WHO-designated neglected-disease pathogen Chlamydia trachomatis (CT) is a gram-negative bacterium responsible for the most frequently diagnosed sexually transmitted infection worldwide. CT infections can lead to infertility, blindness and reactive arthritis, among others. CT acts as an infectious agent by its ability to evade the immune response of its host, which includes the impairment of the NF-κB mediated inflammatory response and the Mcl1 pro-apoptotic pathway through its deubiquitylating, deneddylating and transacetylating enzyme ChlaDUB1 (Cdu1). Expression of Cdu1 is also connected to host cell Golgi apparatus fragmentation, a key process in CT infections.
Cdu1 may this be an attractive drug target for the treatment of CT infections. However, a lead molecule for the development of novel potent inhibitors has been unknown so far. Sequence alignments and phylogenetic searches allocate Cdu1 in the CE clan of cysteine proteases. The adenovirus protease (adenain) also belongs to this clan and shares a high degree of structural similarity with Cdu1. Taking advantage of topological similarities between the active sites of Cdu1 and adenain, a target-hopping approach on a focused set of adenain inhibitors, developed at Novartis, has been pursued. The thereby identified cyano-pyrimidines represent the first active-site directed covalent reversible inhibitors for Cdu1. High-resolution crystal structures of Cdu1 in complex with the covalently bound cyano-pyrimidines as well as with its substrate ubiquitin have been elucidated. The structural data of this thesis, combined with enzymatic assays and covalent docking studies, provide valuable insights into Cdu1s activity, substrate recognition, active site pocket flexibility and potential hotspots for ligand interaction. Structure-informed drug design permitted the optimization of this cyano-pyrimidine based scaffold towards HJR108, the first molecule of its kind specifically designed to disrupt the function of Cdu1. The structures of potentially more potent and selective Cdu1 inhibitors are herein proposed.
This thesis provides important insights towards our understanding of the structural basis of ubiquitin recognition by Cdu1, and the basis to design highly specific Cdu1 covalent inhibitors.
This dissertation explores the development and assessment of inhibitory control – a crucial component of executive functions – in young children. Inhibitory control, defined as the ability to suppress inappropriate responses (Verbruggen & Logan, 2008), is essential for adaptable and goal-oriented behavior. The rapid and non-linear development of this cognitive function in early childhood presents unique challenges for accurate assessment. As children age, they often exhibit a ceiling effect in terms of response accuracy (Petersen et al., 2016), underscoring the need to consider response latency as well. Ideally, combining response latency with accuracy could yield a more precise measure of inhibitory control (e.g., Magnus et al., 2019), facilitating a detailed tracking of developmental changes in inhibitory control across a wider age spectrum. The three studies of this dissertation collectively aim to clarify the relationship between response accuracy, response latency, and inhibitory control across different stages of child development. Each study utilizes a computerized Pointing Stroop Task (Berger et al., 2000) to measure inhibitory control, examining the task's validity and the integration of dual metrics for a more comprehensive evaluation.
The first study focuses on establishing the validity of using both response accuracy and latency as indicators of inhibitory control. Utilizing the framework of explanatory item-response modeling (De Boeck & Wilson, 2004), the study revealed how the task characteristics congruency and item position influence both the difficulty level and timing aspects in young children’s responses in the computerized Pointing Stroop task. Further, this study found that integrating response accuracy with latency, even in a basic manner, provides additional insights. Building upon these findings, the second study investigates the nuances of integrating response accuracy and latency, examining whether this approach can account for age-related differences in inhibitory control. It also explores whether response latencies may contain different information depending on the age and proficiency of the children. The study leverages novel and established methodological perspectives to integrate response accuracy and latency into a single metric, showing the potential applicability of different approaches for assessing inhibitory control development. The third study extends the investigation to a longitudinal perspective, exploring the dynamic relationship between response accuracy, latency, and inhibitory control over time. It assesses whether children who achieve high accuracy at an earlier age show faster improvement in response latency, suggesting a non-linear maturation pathway of inhibitory control. The study also examines if the predictive value of early response latency for later fluid intelligence is dependent on the response accuracy level.
Together, these empirical studies contribute to a more robust understanding of the complex interaction between inhibitory control, response accuracy, and response latency, facilitating valid evaluations of cognitive capabilities in children. Moreover, the findings may have practical implications for designing educational strategies and clinical interventions that address the developmental trajectory of inhibitory control. The nuanced approach advocated in this dissertation suggests prioritizing accuracy in assessment and interventions during the early stages of children's cognitive development, gradually shifting the focus to response latency as children mature and secure their inhibitory control abilities.
The focus of this thesis is on analysing a linear stochastic partial differential equation (SPDE) with a bounded domain. The first part of the thesis commences with an examination of a one-dimensional SPDE. In this context, we construct estimators for the parameters of a parabolic SPDE based on discrete observations of a solution in time and space on a bounded domain. We establish central limit theorems for a high-frequency asymptotic regime, showing substantially smaller asymptotic variances compared to existing estimation methods. Moreover, asymptotic confidence intervals are directly feasible. Our approach builds upon realized volatilities and their asymptotic illustration as the response of a log-linear model with a spatial explanatory variable. This yields efficient estimators based on realized volatilities with optimal rates of convergence and minimal variances. We demonstrate our results by Monte Carlo simulations.
Extending this framework, we analyse a second-order SPDE model in multiple space dimensions in the second part of this thesis and develop estimators for the parameters of this model based on discrete observations in time and space on a bounded domain. While parameter estimation for one and two spatial dimensions was established in recent literature, this is the first work that generalizes the theory to a general, multi-dimensional framework. Our methodology enables the construction of an oracle estimator for volatility within the underlying model. For proving central limit theorems, we use a high-frequency observation scheme. To showcase our results, we conduct a Monte Carlo simulation, highlighting the advantages of our novel approach in a multi-dimensional context.
In den letzten Jahren stieg die Anzahl an förderbedürftigen Schülern sowie an Schülern mit einer Migrations- bzw. Fluchtgeschichte an der Berufsschule. Damit entsteht eine neue Schülerklientel, die von einer hohen Schülerheterogenität und Lernstanddifferenz geprägt ist. Vermehrt sind auch eine sprachliche Armut sowie Lernbeeinträchtigungen zu beobachten.
Die Arbeit mit Sinnbildern im diagnostischen Prozess bei Lernbeeinträchtigungen ist ein kleiner Baustein auf dem Weg dorthin, dass Lernen und damit auch ein Sich-Weiterentwickeln gelingen kann. Dabei präsentiert sich das lösungs- sowie entwicklungsorientierte Verfahren als eine in Beziehung zueinander stehenden Einheit aus Lernbeeinträchtigung, potenzielle Lösung und nahrhaften Boden.
Lernbeeinträchtigung: Der Trias liegt die Annahme zugrunde, dass der Lernprozess des Schülers gestoppt ist. Wenngleich der Schüler spürt, dass da etwas ist, das ihm beim Lernen im Weg steht, so ist er jedoch nicht in der Lage das Gespürte zu verbalisieren.
Nahrhafter Boden: Mit Hilfe eines von Sinnbildern gestützten Interviews soll es gelingen, die vagen Vermutungen der Schüler hinsichtlich ihrer Lernbeeinträchtigung zu versprachlichen. Dabei spielt die von den Bildern ausgehende Resonanz eine entscheidende Rolle. Durch sie können dem Schüler eigene implizite Denk- und Handlungsmuster gedanklich zugänglich gemacht und versprachlicht werden.
Potenzielle Lösung: Die im Rahmen des Sinnbildgestützten Interviews in Erfahrung gebrachten Informationen ermöglichen im besten Fall eine Sicht darauf, was dem Schüler in seinem gestoppten Lernprozess im Weg steht. Dabei geht es nicht darum eine kausale Ursache zu finden, sondern eine prozessorientierte sowie lösungsorientierte Sichtweise einzunehmen.
Die Versprachlichung der vagen Vermutungen ermöglicht ein Arbeiten mit dem Wissen in der realen Welt. Im Falle von Gelingen, kann der Interviewführende die durch das Sinnbildgestützte Interview in Erfahrung gebrachten Lernbeeinträchtigungen innerhalb der drei Lerndimensionen im Können, Wissen und Wollen (Ellinger/Hechler 2021) verorten, um eine individuelle -auf die Lernbeeinträchtigung zugeschnittene- Lernhilfe zu generieren.
Die Jahresabschlussprüfung verfolgt das Ziel, die Verlässlichkeit der Rechnungslegung zu bestätigen. Folglich kann sie einen wesentlichen Beitrag zu einem hohen Informationsniveau an den Märkten leisten. Angesichts dieser großen ökonomischen Bedeutung unternimmt der deutsche Gesetzgeber zahlreiche Anstrengungen, um eine hohe Prüfungsqualität sicherzustellen.
Die Sichtung der Wirtschaftsprüferordnung zeigt hierbei, dass regulatorische Maßnahmen ergriffen werden, die am Kern der Jahresabschlussprüfung ansetzen, nämlich an den Berufsangehörigen selbst. So wurde der Zugang zum Berufsstand der vereidigten Buchprüfer mehrmals geschlossen und wiedereröffnet. Des Weiteren sind markante Anpassungen des Niveaus des Wirtschaftsprüfungsexamens im Zeitablauf zu erkennen. Bei der Jahresabschlussprüfung der Unternehmen von öffentlichem Interesse sind außerdem besondere Berufspflichten zu erfüllen. Zum einen ist diesen schweren Eingriffen in die Freiheit der Berufswahl und der Berufsausübung gemein, dass sie allesamt die Qualifikation des Abschlussprüfers adressieren. Zum anderen werden die entsprechenden Gesetzesänderungen mehrheitlich mit einer Stärkung der Prüfungsqualität begründet.
Fraglich ist, inwiefern jene Facetten der Prüferqualifikation tatsächlich einen Einfluss auf die Prüfungsqualität ausüben. Aufgrund mangelnder Evidenz ergibt sich die Notwendigkeit, eine empirische Studie am deutschen Prüfermarkt durchzuführen und somit den Beginn zur Schließung der identifizierten Forschungslücke zu setzen.
Das Ziel der vorliegenden Dissertation besteht folglich darin, den Zusammenhang zwischen der Prüferqualifikation und der Prüfungsqualität mittels Regressionsanalysen zu untersuchen. Dazu wurde ein einzigartiger Datensatz zu deutschen privaten prüfungspflichtigen Kapitalgesellschaften mit unkonsolidierten Finanz- und Prüferinformationen im Zeitraum 2006-2018 mit insgesamt 217.585 grundlegenden Beobachtungen erhoben, bereinigt und aufbereitet. Da die Prüfungsqualität nicht direkt beobachtbar ist, wird zwischen wahrgenommener Prüfungsqualität und tatsächlicher Prüfungsqualität unterschieden. Im Rahmen dieser Dissertation wird die wahrgenommene Prüfungsqualität über Fremdkapitalkosten und die tatsächliche Prüfungsqualität über absolute diskretionäre Periodenabgrenzungen approximiert.
Die Ergebnisse der Hauptregressionen zeigen überwiegend, dass kein Zusammenhang zwischen den Maßgrößen der Prüferqualifikation und der wahrgenommenen und tatsächlichen Prüfungsqualität besteht. Die Zusatz- und Sensitivitätsanalysen unterstützen diesen Befund. So können mit Blick auf die Berufszugangsregelungen keine Qualitätsunterschiede zwischen den Berufsständen der Wirtschaftsprüfer und der vereidigten Buchprüfer nachgewiesen werden. Auch innerhalb des Berufstandes der Wirtschaftsprüfer ergeben sich keine Hinweise auf ein Qualitätsgefälle zwischen den Prüfergruppen, die unterschiedliche Examensanforderungen durchlebt haben. Hinsichtlich der Berufsausübungsregelungen ist zu beobachten, dass die zusätzlichen Anforderungen an die Jahresabschlussprüfung der Unternehmen von öffentlichem Interesse nicht mit einer anderen Prüfungsqualität bei privaten Unternehmen verbunden sind. Die beschriebenen regulatorischen Schritte des Gesetzgebers im Bereich der Prüferqualifikation erscheinen somit im Lichte einer verbesserten Prüfungsqualität nicht zwingend gerechtfertigt.
Two-dimensional lattices are in the focus of research in modern solid state physics due to their novel and exotic electronic properties with tremendous potential for seminal future applications. Of particular interest within this research field are quantum spin Hall insulators which are characterized by an insulating bulk with symmetry-protected metallic edge states. For electrons within these one-dimensional conducting channels, spin-momentum locking enables dissipationless transport - a property which promises nothing short of a revolution for electronic devices. So far, however, quantum spin Hall materials require enormous efforts to be realized such as cryogenic temperatures or ultra-high vacuum. A potential candidate to overcome these shortcomings are two-dimensional lattices of the topological semi-metal antimony due to their potential to host the quantum spin Hall effect while offering improved resilience against oxidation.
In this work, two-dimensional lattices of antimony on different substrates, namely Ag(111), InSb(111) and SiC(0001), are investigated regarding their atomic structure and electronic properties with complimentary surface sensitive techniques. In addition, a systematic oxidation study compares the stability of Sb-SiC(0001) with that of the two-dimensional topological insulators bismuthene-SiC(0001) and indenene-SiC(0001).
A comprehensive experimental analysis of the \((\sqrt{3}\times\sqrt{3})R30^\circ\) Sb-Ag(111) surface, including X-ray standing wave measurements, disproves the proclaimed formation of a buckled antimonene lattice in literature. The surface lattice can instead be identified as a metallic Ag\(_2\)Sb surface alloy.
Antimony on InSb(111) shows an unstrained Volmer-Weber island growth due to its large lattice mismatch to the substrate. The concomitant moir\'{e} situation at the interface imprints mainly in a periodic height corrugation of the antimony islands which as observed with scanning tunneling microscopy. On islands with various thicknesses, quasiparticle interference patterns allow to trace the topological surface state of antimony down to the few-layer limit.
On SiC(0001), two different two-dimensional antimony surface reconstructions are identified. Firstly, a metallic triangular $1\times1$ lattice which constitutes the antimony analogue to the topological insulator indenene. Secondly, an insulating asymmetric kagome lattice which represents the very first realized atomic surface kagome lattice.
A comparative, systematic oxidation study of elemental (sub-)monolayer materials on SiC(0001) reveals a high sensitivity of indenene and bismuthene to small dosages of oxygen. An improved resilience is found for Sb-SiC(0001) which, however, oxidizes nevertheless if exposed to oxygen. These surface lattices are therefore not suitable for future applications without additional protective measures.
In this thesis, a variety of Fokker--Planck (FP) optimal control problems are investigated. Main emphasis is put on a first-- and second--order analysis of different optimal control problems, characterizing optimal controls, establishing regularity results for optimal controls, and providing a numerical analysis for a Galerkin--based numerical scheme.
The Fokker--Planck equation is a partial differential equation (PDE) of linear parabolic type deeply connected to the theory of stochastic processes and stochastic differential equations. In essence, it describes the evolution over time of the probability distribution of the state of an object or system of objects under the influence of both deterministic and stochastic forces.
The FP equation is a cornerstone in understanding and modeling phenomena ranging from the diffusion and motion of molecules in a fluid to the fluctuations in financial markets.
Two different types of optimal control problems are analyzed in this thesis. On the one hand, Fokker--Planck ensemble optimal control problems are considered that have a wide range of applications in controlling a system of multiple non--interacting objects. In this framework, the goal is to collectively drive each object into a desired state.
On the other hand, tracking--type control problems are investigated, commonly used in parameter identification problems or stemming from the field of inverse problems.
In this framework, the aim is to determine certain parameters or functions of the FP equation, such that the resulting probability distribution function takes a desired form, possibly observed by measurements.
In both cases, we consider FP models where the control functions are part of the drift, arising only from the deterministic forces of the system. Therefore, the FP optimal control problem has a bilinear control structure.
Box constraints on the controls may be present, and the focus is on time--space dependent controls for ensemble--type problems and on only time--dependent controls for tracking--type optimal control problems.
In the first chapter of the thesis, a proof of the connection between the FP equation and stochastic differential equations is provided. Additionally, stochastic optimal control problems, aiming to minimize an expected cost value, are introduced, and the corresponding formulation within a deterministic FP control framework is established.
For the analysis of this PDE--constrained optimal control problem, the existence, and regularity of solutions to the FP problem are investigated. New $L^\infty$--estimates for solutions are established for low space dimensions under mild assumptions on the drift. Furthermore, based on the theory of Bessel potential spaces, new smoothness properties are derived for solutions to the FP problem in the case of only time--dependent controls. Due to these properties, the control--to--state map, which associates the control functions with the corresponding solution of the FP problem, is well--defined, Fréchet differentiable and compact for suitable Lebesgue spaces or Sobolev spaces.
The existence of optimal controls is proven under various assumptions on the space of admissible controls and objective functionals. First--order optimality conditions are derived using the adjoint system. The resulting characterization of optimal controls is exploited to achieve higher regularity of optimal controls, as well as their state and co--state functions.
Since the FP optimal control problem is non--convex due to its bilinear structure, a first--order analysis should be complemented by a second--order analysis.
Therefore, a second--order analysis for the ensemble--type control problem in the case of $H^1$--controls in time and space is performed, and sufficient second--order conditions are provided. Analogous results are obtained for the tracking--type problem for only time--dependent controls.
The developed theory on the control problem and the first-- and second--order optimality conditions is applied to perform a numerical analysis for a Galerkin discretization of the FP optimal control problem. The main focus is on tracking-type problems with only time--dependent controls. The idea of the presented Galerkin scheme is to first approximate the PDE--constrained optimization problem by a system of ODE--constrained optimization problems. Then, conditions on the problem are presented such that the convergence of optimal controls from one problem to the other can be guaranteed.
For this purpose, a class of bilinear ODE--constrained optimal control problems arising from the Galerkin discretization of the FP problem is analyzed. First-- and second--order optimality conditions are established, and a numerical analysis is performed. A discretization with linear finite elements for the state and co--state problem is investigated, while the control functions are approximated by piecewise constant or piecewise quadratic continuous polynomials. The latter choice is motivated by the bilinear structure of the optimal control problem, allowing to overcome the discrepancies between a discretize--then--optimize and optimize--then--discretize approach. Moreover, second--order accuracy results are shown using the space of continuous, piecewise quadratic polynomials as the discrete space of controls. Lastly, the theoretical results and the second--order convergence rates are numerically verified.
This work presents the first ILT observations of high redshift blazars and their study in terms of jet evolution, morphology, and interaction with the surrounding medium. Each of these represents a highly topical area of astronomywith a large number of open questions. To better understand Active Galactic Nuclei (AGN) and their fundamental inner workings, new techniques are needed to exploit the full potential of the next generation of radio interferometers. Some of these tools are presented here and applied to one of the latest generation of software radio telescopes. A major focus of the studies presented is on the unification model, where the observed blazars are discussed for their properties to be rotated counterparts of Fanaroff-Riley Class II (FR-II) radio galaxies, when classified as Flat Spectrum Radio Quasars (FSRQs). In addition, multiwavelength information has been included in the analysis. Both studies are feasibility studies that will serve as a basis for future similar studies. The characteristics discussed and their interpretation do not allow conclusions to be drawn for their respective populations. However, by applying them to a larger number of targets, population studies will be possible. The first chapters introduce the necessary topics, AGN, principles of radio observations and ILT, in the necessary depth to provide the reader with a solid knowledge base. They are particularly important for understanding the current limits and influences of uncertainties in the observation, calibration and imaging process. But they also shed light on realistic future improvements. A particular focus is on the development and evolution of the LOw-Frequency ARray (LOFAR)-Very Long Baseline Interferometry (VLBI) pipeline. With the tools at hand, the first study addresses the high redshift blazar S5 0836+710 $(z=2.218)$, which has been observed at various wavelengths and resolutions. It has a disrupted one-sided jet with an associated extended region further out. Despite the excellent wavelength coverage, only the additional ILT observations provided a complete picture of the source. With the data, the extended region could be classified as a hotspot moving at slightly relativistic speeds.. With the ILT data it was also possible to extract the flux of the core region of the AGN, and in projection to reveal the mixed counter-hotspot behind it. This also allowed constraints on jet parameters and environmental properties to be modelled, which were previously inconclusive. Technically, this study shows that the ILT can be used as an effective VLBI array for compact sources with small angular scales. However, the detection of faint components beyond redshifts of $z=2$ may require the capabilities of the Square Kilometre Array (SKA) to provide a significant number of detections to enable statistical conclusions. The second study uses a much improved calibration pipeline to analyse the high redshift blazar GB1508+5714 $(z=4.30)$. The ILT data revealed a previously unseen component in the eastern direction. A spectral index map was generated from the Karl G. Jansky Very Large Array (VLA) data, showing spectral index values of $-1.2_{-0.2}^{+0.4}$ for the western component, steeper than $-1.1$ for the eastern region, and $0.023 \pm 0.007$ for the core. Using the information provided by the ILT observation, as well as multi-wavelength information from other observations ranging from the long radio wavelengths to the $\gamma$ regime, four models were developed to interpret the observed flux with different emission origins. This also allowed to test a proposed interaction channel of the electrons provided by the jet, to cool off via inverse compton scattering with the Cosmic Microwave Background (CMB) photons, rather than by the usual synchrotron emission. This is referred to as cmb quenching in the literature, which could be shown in the study, to be necessary in any case. Finally, one of the four models was considered in which the hotspots in the detected components are unresolved and mixed by the lobe emission, with the X-ray emission coming from the lobes and partially mixed by the bright core region. The results of this preferred model are consistent with hotspots in a state of equipartition and lobes almost so. The study shows that high redshift blazars can be studied with the ILT, and expanding the sample of high redshift blazars resolved at multiple frequencies will allow a statistical study of the population. Finally, this work successfully demonstrates the powerful capabilities of the ILT to address questions that were previously inaccessible. The current state of the LOFAR-VLBI pipeline, when properly executed, allows work on the most challenging objects and will only improve in the future. In particular, this gives a glimpse of the possibilities that SKA will bring to astronomy.
Vorliegende Untersuchung am Universitätsklinikum Würzburg sowie die Befragung von Anästhesisten/Anästhesistinnen im Raum der 3 DACH-Länder zeigen, dass bildgebende Verfahren bei Säuglingen mit einer niedrigen Rate an Komplikationen, zumeist in medikamentöser Sedierung mit Propofol, durchgeführt werden. Wie international üblich ist im Säuglingsalter die Magnetresonanztomographie das bildgebende Verfahren der Wahl und wird, mit überzeugender Häufigkeit, erfolgreich durchgeführt.
Die Untersuchung am Universitätsklinikum Würzburg legt nahe, dass männliche Säuglinge häufiger eine Bildgebung benötigen und häufiger höheren ASA-Kategorie zugeschrieben werden. Dabei scheinen sie auch häufiger Komplikationen zu erleben und bedürfen daher besonderer Aufmerksamkeit. Eine eventuelle Alternative zur Sedierung kann dabei die „feed-and-sleep“ Methode darstellen. In unserer Umfrage konnten wir erheben, dass diese Methode bisher wenig verbreitet ist, obwohl in diesem Zusammenhang eventuell Abläufe und Prozesszeiten strukturiert und optimiert werden können, da beispielsweise die Nachüberwachung entfällt. Vorstellbar wäre beispielsweise, mehrere Säuglinge zum gleichen Zeitpunkt ins MRT zu bestellen, um gegebenenfalls den am frühesten eingeschlafenen Säugling vorzuziehen. Diese Methode sollte zukünftig Einzug in die wissenschaftliche Untersuchung von bildgebenden Verfahren bei Säuglingen finden.
Die Umfrage im deutschsprachigen Raum zeigt eine Leitlinien-gerechte Betreuung von Säuglingen für bildgebende Verfahren, die mit einer hohen Qualität, und zumeist erfolgreich von erfahrenen Anästhesisten/Anästhesistinnen durchgeführt wird. Eventuelle Verbesserungen können im Bereich der Ausbildung nachfolgender Ärztinnen/Ärzte und in der häufigeren Verwendung der „feed-and-sleep“ Methode liegen, die vielen Kollegen/Kolleginnen bekannt ist, aber nur selten durchgeführt wird.
Ziel ist eine qualitativ hochwertige, schnellstmöglich durchgeführte Bildgebung, die ohne oder mit der niedrigst möglichen Dosierung eines sedierenden Medikamentes zu erreichen ist.
This paper is devoted to a theoretical and numerical investigation of Nash equilibria and Nash bargaining problems governed by bilinear (input-affine) differential models. These systems with a bilinear state-control structure arise in many applications in, e.g., biology, economics, physics, where competition between different species, agents, and forces needs to be modelled. For this purpose, the concept of Nash equilibria (NE) appears appropriate, and the building blocks of the resulting differential Nash games are different control functions associated with different players that pursue different non-cooperative objectives. In this framework, existence of Nash equilibria is proved and computed with a semi-smooth Newton scheme combined with a relaxation method. Further, a related Nash bargaining (NB) problem is discussed. This aims at determining an improvement of all players’ objectives with respect to the Nash equilibria. Results of numerical experiments successfully demonstrate the effectiveness of the proposed NE and NB computational framework.
Rag1\(^{−/−}\) mice, lacking functional B and T cells, have been extensively used as an adoptive transfer model to evaluate neuroinflammation in stroke research. However, it remains unknown whether natural killer (NK) cell development and functions are altered in Rag1\(^{−/−}\) mice as well. This connection has been rarely discussed in previous studies but might have important implications for data interpretation. In contrast, the NOD-Rag1\(^{null}\)IL2rg\(^{null}\) (NRG) mouse model is devoid of NK cells and might therefore eliminate this potential shortcoming. Here, we compare immune-cell frequencies as well as phenotype and effector functions of NK cells in Rag1\(^{−/−}\) and wildtype (WT) mice using flow cytometry and functional in vitro assays. Further, we investigate the effect of Rag1\(^{−/−}\) NK cells in the transient middle cerebral artery occlusion (tMCAO) model using antibody-mediated depletion of NK cells and adoptive transfer to NRG mice in vivo. NK cells in Rag1\(^{−/−}\) were comparable in number and function to those in WT mice. Rag1\(^{−/−}\) mice treated with an anti-NK1.1 antibody developed significantly smaller infarctions and improved behavioral scores. Correspondingly, NRG mice supplemented with NK cells were more susceptible to tMCAO, developing infarctions and neurological deficits similar to Rag1−/− controls. Our results indicate that NK cells from Rag1−/− mice are fully functional and should therefore be considered in the interpretation of immune-cell transfer models in experimental stroke. Fortunately, we identified the NRG mice, as a potentially better-suited transfer model to characterize individual cell subset-mediated neuroinflammation in stroke.
Despite successful recanalization of large-vessel occlusions in acute ischemic stroke, individual patients profit to a varying degree. Dynamic susceptibility-weighted perfusion and dynamic T1-weighted contrast-enhanced blood-brain barrier permeability imaging may help to determine secondary stroke injury and predict clinical outcome. We prospectively performed perfusion and permeability imaging in 38 patients within 24 h after successful mechanical thrombectomy of an occlusion of the middle cerebral artery M1 segment. Perfusion alterations were evaluated on cerebral blood flow maps, blood-brain barrier disruption (BBBD) visually and quantitatively on ktrans maps and hemorrhagic transformation on susceptibility-weighted images. Visual BBBD within the DWI lesion corresponded to a median ktrans elevation (IQR) of 0.77 (0.41–1.4) min−1 and was found in all 7 cases of hypoperfusion (100%), in 10 of 16 cases of hyperperfusion (63%), and in only three of 13 cases with unaffected perfusion (23%). BBBD was significantly associated with hemorrhagic transformation (p < 0.001). While BBBD alone was not a predictor of clinical outcome at 3 months (positive predictive value (PPV) = 0.8 [0.56–0.94]), hypoperfusion occurred more often in patients with unfavorable clinical outcome (PPV = 0.43 [0.10–0.82]) compared to hyperperfusion (PPV = 0.93 [0.68–1.0]) or unaffected perfusion (PPV = 1.0 [0.75–1.0]). We show that combined perfusion and permeability imaging reveals distinct infarct signatures after recanalization, indicating the severity of prior ischemic damage. It assists in predicting clinical outcome and may identify patients at risk of stroke progression.
Metastatic pheochromocytoma and paraganglioma: signs and symptoms related to catecholamine secretion
(2021)
Background
The presence or future development of metastatic pheochromocytomas or paragangliomas (mPPGLs) can be difficult to diagnose or predict at initial presentation. Since production of catecholamines from mPPGLs is different from non-metastatic tumors (non-mPPGLs), this study aimed to clarify whether presenting catecholamine-related signs and symptoms (cSS) might also differ.
Methods
The study included 249 patients, 43 with mPPGL and 206 with non-mPPGL. Clinical data at the time of biochemical diagnosis (i.e. at entry into the study) were used to generate a cumulative score of cSS for each patient.
Results
Patients with mPPGL were significantly younger (43.3 ± 14 vs. 48.9 ± 16.1 years) and included a lower proportion of females (39.5% vs. 60.7%) than patients with non-mPPGLs. Frequencies of signs and symptoms did not differ between the two groups. Patients with mPPGLs had lower (P < 0.001) urinary excretion of epinephrine (3.5 (IQR, 1.9—6.5) µg/day) than those with non-mPPGLs (19.1 (IQR, 4.3—70.2) µg/day). There was no difference in urinary excretion of norepinephrine. In patients with mPPGLs a high cSS score was associated with high urinary excretion of norepinephrine and normetanephrine. In contrast, in patients with non-mPPGLs, a high cSS was associated with high urinary excretion of epinephrine and metanephrine.
Conclusion
Although presenting signs and symptoms were associated with production of norepinephrine in patients with mPPGLs and of epinephrine in patients with non-mPPGLs, there were no differences in signs and symptoms between the two groups. Therefore, consideration of signs and symptoms does not appear helpful for distinguishing patients with and without mPPGLs.
Despite the widespread application of landslide susceptibility analyses, there is hardly any information about whether or not the occurrence of recent landslide events was correctly predicted by the relevant susceptibility maps. Hence, the objective of this study is to evaluate four landslide susceptibility maps retrospectively in a landslide-prone area of the Swabian Alb (Germany). The predictive performance of each susceptibility map is evaluated based on a landslide event triggered by heavy rainfalls in the year 2013. The retrospective evaluation revealed significant variations in the predictive accuracy of the analyzed studies. Both completely erroneous as well as very precise predictions were observed. These differences are less attributed to the applied statistical method and more to the quality and comprehensiveness of the used input data. Furthermore, a literature review of 50 peer-reviewed articles showed that most landslide susceptibility analyses achieve very high validation scores. 73% of the analyzed studies achieved an area under curve (AUC) value of at least 80%. These high validation scores, however, do not reflect the high uncertainty in statistical susceptibility analysis. Thus, the quality assessment of landslide susceptibility maps should not only comprise an index-based, quantitative validation, but also an additional qualitative plausibility check considering local geomorphological characteristics and local landslide mechanisms. Finally, the proposed retrospective evaluation approach cannot only help to assess the quality of susceptibility maps and demonstrate the reliability of such statistical methods, but also identify issues that will enable the susceptibility maps to be improved in the future.
Background
Individuals’ physical and mental health, as well as their chances of returning to work after their ability to work is damaged, can be addressed by medical rehabilitation.
Aim
This study investigated the developmental trends of mental and physical health among patients in medical rehabilitation and the roles of self-efficacy and physical fitness in the development of mental and physical health.
Design
A longitudinal design that included four time-point measurements across 15 months.
Setting
A medical rehabilitation center in Germany.
Population
Participants included 201 patients who were recruited from a medical rehabilitation center.
Methods
To objectively measure physical fitness (lung functioning), oxygen reabsorption at anaerobic threshold (VO2AT) was used, along with several self-report scales.
Results
We found a nonlinear change in mental health among medical rehabilitation patients. The results underscored the importance of medical rehabilitation for patients’ mental health over time. In addition, patients’ physical health was stable over time. The initial level of physical fitness (VO2AT) positively predicted their mental health and kept the trend more stable. Self-efficacy appeared to have a positive relationship with mental health after rehabilitation treatment.
Conclusions
This study revealed a nonlinear change in mental health among medical rehabilitation patients. Self-efficacy was positively related to mental health, and the initial level of physical fitness positively predicted the level of mental health after rehabilitation treatment.
Clinical Rehabilitation
More attention could be given to physical capacity and self-efficacy for improving and maintaining rehabilitants’ mental health.
In this study, we examined the conditional indirect and direct relations of pain-related cognitions to depression. Subjective helplessness was included as presumably mediating the relations of catastrophizing and thought suppression to depression due to motivational deficits. In addition, moderating effects of dispositional action versus state orientation were analyzed, whereby state orientation indicates volitional deficits in coping with distress. The study was based on self-report data from 536 patients with chronic non-specific low back pain at the beginning of inpatient rehabilitation. Moderated mediation analyses were performed. The indirect catastrophizing- and thought suppression-depression relations were (partially) mediated by subjective helplessness; and moderated by failure-related action versus state orientation. Moreover, action versus state orientation moderated the direct relation of thought suppression to depression. Results suggest that catastrophizing, thought suppression, and subjective helplessness do not lead to depression unless associated with self-regulatory inability (i.e., state orientation). In contrast, action-oriented patients more effectively self-regulate pain-related emotions, disengage from rumination, and distract from pain and thus better avoid the debilitating effects of negative pain-related cognitions on depression. Future research and treatment may more strongly focus on the role of motivational and volitional deficits underlying learned helplessness and depression in chronic pain.
Purpose
The subclassification of adrenal cancers according to the WHO classification in ordinary, myxoid, oncocytic, and sarcomatoid as well as pediatric types is well established, but the criteria for each subtype are not sufficiently determined and the relative frequency of the different types of adrenal cancers has not been studied in large cohorts. Therefore, our large collection of surgically removed adrenal cancers should be reviewed o establish the criteria for the subtypes and to find out the frequency of the various types.
Methods
In our series of 521 adrenal cancers the scoring systems of Weiss et al., Hough et al., van Slooten et al. and the new Helsinki score system were used for the ordinary type of cancer (97% of our series) and the myxoid type (0.8%). For oncocytic carcinomas (2%), the scoring system of Bisceglia et al. was applied.
Results
Discrepancies between benign and malignant diagnoses from the first thee classical scoring systems are not rare (22% in our series) and could be resolved by the Helsinki score especially by Ki-67 index (more than 8% unequivocally malignant). Since all our cancer cases are positive in the Helsinki score, this system can replace the three elder systems. For identification of sarcomatoid cancer as rarest type in our series (0.2%), the scoring systems are not practical but additional immunostainings used for soft tissue tumors and in special cases molecular pathology are necessary to differentiate these cancers from adrenal sarcomas. According to the relative frequencies of the different subtypes of adrenal cancers the main type is the far most frequent (97%) followed by the oncocytic type (2%), the myxoid type (0.8%) and the very rare sarcomatoid type (0.2%).
Conclusions
The Helsinki score is the best for differentiating adrenal carcinomas of the main, the oncocytic, and the myxoid type in routine work. Additional scoring systems for these carcinomas are generally not any longer necessary. Signs of proliferation (mitoses and Ki-67 index) and necroses are the most important criteria for diagnosis of malignancy.
Context
Primary aldosteronism (PA) is the most frequent form of endocrine hypertension. Besides its deleterious impact on cardiovascular target organ damage, PA is considered to cause osteoporosis.
Patients and methods
We assessed bone turnover in a subset of 36 postmenopausal women with PA. 18 patients had unilateral PA and were treated by adrenalectomy, whereas 18 patients had bilateral PA and received mineralocorticoid receptor antagonist (MRA) therapy respectively. 18 age- and BMI-matched females served as controls. To estimate bone remodeling, we measured the bone turnover markers intact procollagen 1 N-terminal propeptide, bone alkaline phosphatase, osteocalcin and tartrate resistant acid phosphatase 5b in plasma by chemiluminescent immunoassays at time of diagnosis and one year after initiation of treatment.
Study design
Observational longitudinal cohort study.
Setting
Tertiary care hospital.
Results
Compared with controls, patients with PA had mildly elevated osteocalcin at baseline (p = 0.013), while the other bone markers were comparable between both groups. There were no differences between the unilateral and the bilateral PA subgroup. One year after initiation of MRA treatment with spironolactone bone resorption and bone formation markers had significantly decreased in patients with bilateral PA. In contrast, patients adrenalectomized because of unilateral PA showed no significant change of bone turnover markers.
Conclusion
This study shows that aldosterone excess in postmenopausal women with PA is not associated with a relevant increase of bone turnover markers at baseline. However, we observed a significant decrease of bone markers in patients treated with spironolactone, but not in patients treated by adrenalectomy.
Purpose
Pheochromocytomas and Paragangliomas (PPGL) result in chronic catecholamine excess and serious health complications. A recent study obtained a metabolic signature in plasma from PPGL patients; however, its targeted nature may have generated an incomplete picture and a broader approach could provide additional insights. We aimed to characterize the plasma metabolome of PPGL patients before and after surgery, using an untargeted approach, and to broaden the scope of the investigated metabolic impact of these tumors.
Design
A cohort of 36 PPGL patients was investigated. Blood plasma samples were collected before and after surgical tumor removal, in association with clinical and tumor characteristics.
Methods
Plasma samples were analyzed using untargeted nuclear magnetic resonance (NMR) spectroscopy metabolomics. The data were evaluated using a combination of uni- and multi-variate statistical methods.
Results
Before surgery, patients with a nonadrenergic tumor could be distinguished from those with an adrenergic tumor based on their metabolic profiles. Tyrosine levels were significantly higher in patients with high compared to those with low BMI. Comparing subgroups of pre-operative samples with their post-operative counterparts, we found a metabolic signature that included ketone bodies, glucose, organic acids, methanol, dimethyl sulfone and amino acids. Three signals with unclear identities were found to be affected.
Conclusions
Our study suggests that the pathways of glucose and ketone body homeostasis are affected in PPGL patients. BMI-related metabolite levels were also found to be altered, potentially linking muscle atrophy to PPGL. At baseline, patient metabolomes could be discriminated based on their catecholamine phenotype.
Therapy options for adrenal insufficiency and recommendations for the management of adrenal crisis
(2021)
Adrenal insufficiency (AI) is a life-threatening condition requiring life-long glucocorticoid (GC) substitution therapy, as well as stress adaptation to prevent adrenal crises. The number of individuals with primary and secondary adrenal insufficiency in Europe is estimated to be 20–50/100.000. A growing number of AI cases are due to side effects of GC treatment used in different treatment strategies for cancer and to immunotherapy in cancer treatment. The benefit of hormone replacement therapy is evident but long-term adverse effects may arise due to the non-physiological GC doses and treatment regimens used. Given multiple GC replacement formulations available comprising short-acting, intermediate, long-acting and novel modified-release hydrocortisone as well as subcutaneous formulations, this review offers a concise summary on the latest therapeutic improvements for treatment of AI and prevention of adrenal crises. As availability of various glucocorticoid formulations and access to expert centers across Europe varies widely, European Reference Networks on rare endocrine conditions aim at harmonizing treatment and ensure access to specialized patient care for individual case-by-case treatment decisions. To improve the availability across Europe to cost effective oral and parenteral formulations of hydrocortisone will save lives.
Differences between immunotherapy-induced and primary hypophysitis—a multicenter retrospective study
(2022)
Objective
Immune checkpoint inhibitors can cause various immune-related adverse events including secondary hypophysitis. We compared clinical characteristics of immunotherapy-induced hypophysitis (IIH) and primary hypophysitis (PH)
Design
Retrospective multicenter cohort study including 56 patients with IIH and 60 patients with PH.
Methods
All patients underwent extensive endocrine testing. Data on age, gender, symptoms, endocrine dysfunction, MRI, immunotherapeutic agents and autoimmune diseases were collected.
Results
Median time of follow-up was 18 months in IIH and 69 months in PH. The median time from initiation of immunotherapy to IIH diagnosis was 3 months. IIH affected males more frequently than PH (p < 0.001) and led to more impaired pituitary axes in males (p < 0.001). The distribution of deficient adenohypophysial axes was comparable between both entities, however, central hypocortisolism was more frequent (p < 0.001) and diabetes insipidus considerably less frequent in IIH (p < 0.001). Symptoms were similar except that visual impairment occurred more rarely in IIH (p < 0.001). 20 % of IIH patients reported no symptoms at all. Regarding MRI, pituitary stalk thickening was less frequent in IIH (p = 0.009). Concomitant autoimmune diseases were more prevalent in PH patients before the diagnosis of hypophysitis (p = 0.003) and more frequent in IIH during follow-up (p = 0.002).
Conclusions
Clinically, IIH and PH present with similar symptoms. Diabetes insipidus very rarely occurs in IIH. Central hypocortisolism, in contrast, is a typical feature of IIH. Preexisting autoimmunity seems not to be indicative of developing IIH.
Systemic chemotherapy of pediatric recurrent ependymomas: results from the German HIT-REZ studies
(2021)
Purpose
Survival in recurrent ependymoma (EPN) depends mainly on the extent of resection achieved. When complete resection is not feasible, chemotherapy is often used to extend progression-free and overall survival. However, no consistent effect of chemotherapy on survival has been found in patients with recurrent EPN.
Methods
Systemic chemotherapeutic treatment of 138 patients enrolled in the German HIT-REZ-studies was analyzed. Survival depending on the use of chemotherapy, disease-stabilization rates (RR), duration of response (DOR) and time to progression (TTP) were estimated.
Results
Median age at first recurrence was 7.6 years (IQR: 4.0–13.6). At first recurrence, median PFS and OS were 15.3 (CI 13.3–20.0) and 36.9 months (CI 29.7–53.4), respectively. The Hazard Ratio for the use of chemotherapy in local recurrences in a time-dependent Cox-regression analysis was 0.99 (CI 0.74–1.33). Evaluable responses for 140 applied chemotherapies were analyzed, of which sirolimus showed the best RR (50%) and longest median TTP [11.51 (CI 3.98; 14.0) months] in nine patients, with the strongest impact found when sirolimus was used as a monotherapy. Seven patients with progression-free survival > 12 months after subtotal/no-resection facilitated by chemotherapy were found. No definitive survival advantage for any drug in a specific molecularly defined EPN type was found.
Conclusion
No survival advantage for the general use of chemotherapy in recurrent EPN was found. In cases with incomplete resection, chemotherapy was able to extend survival in individual cases. Sirolimus showed the best RR, DOR and TTP out of all drugs analyzed and may warrant further investigation.
Strategies to Enhance Retention in a Cohort Study Among Adults of Turkish Descent Living in Berlin
(2022)
Retention is important for statistical power and external validity in long-term cohort studies. The aims of our study were to evaluate different retention strategies within a cohort study of adults of Turkish descent in Berlin, Germany, and to compare participants and non-participants. In 2011–2012, a population-based study was conducted among adults of Turkish descent to primarily examine recruitment strategies. 6 years later, the participants were re-contacted and invited to complete a self-report questionnaire regarding their health status, health care utilization, and satisfaction with medical services. The retention strategy comprised letters in both German and Turkish, phone calls, and home visits (by bilingual staff). We calculated the response rate and retention rate, using definitions of the American Association for Public Opinion Research, as well as the relative retention rate for each level of contact. Associations of baseline recruitment strategy, sociodemographic, migration-related and health-related factors with retention were investigated by logistic regression analysis. Of 557 persons contacted, 249 (44.7%) completed the questionnaire. This was 50.1% of those whose contact information was available. The relative retention rate was lowest for phone calls (8.9%) and highest for home visits (18.4%). Participants were more often non-smokers and German citizens than non-participants. For all remaining factors, no association with retention was found. In this study, among adults of Turkish descent, the retention rate increased considerably with every additional level of contact. Implementation of comprehensive retention strategies provided by culturally matched study personnel may lead to higher validity and statistical power in studies on migrant health issues.
Purpose
Biallelic pathogenic NBAS variants manifest as a multisystem disorder with heterogeneous clinical phenotypes such as recurrent acute liver failure, growth retardation, and susceptibility to infections. This study explores how NBAS-associated disease affects cells of the innate and adaptive immune system.
Methods
Clinical and laboratory parameters were combined with functional multi-parametric immunophenotyping methods in fifteen NBAS-deficient patients to discover possible alterations in their immune system.
Results
Our study revealed reduced absolute numbers of mature CD56dim natural killer (NK) cells. Notably, the residual NK cell population in NBAS-deficient patients exerted a lower potential for activation and degranulation in response to K562 target cells, suggesting an NK cell–intrinsic role for NBAS in the release of cytotoxic granules. NBAS-deficient NK cell activation and degranulation was normalized upon pre-activation by IL-2 in vitro, suggesting that functional impairment was reversible. In addition, we observed a reduced number of naïve B cells in the peripheral blood associated with hypogammaglobulinemia.
Conclusion
In summary, we demonstrate that pathogenic biallelic variants in NBAS are associated with dysfunctional NK cells as well as impaired adaptive humoral immunity.
Amantadine: reappraisal of the timeless diamond—target updates and novel therapeutic potentials
(2021)
The aim of the current review was to provide a new, in-depth insight into possible pharmacological targets of amantadine to pave the way to extending its therapeutic use to further indications beyond Parkinson’s disease symptoms and viral infections. Considering amantadine’s affinities in vitro and the expected concentration at targets at therapeutic doses in humans, the following primary targets seem to be most plausible: aromatic amino acids decarboxylase, glial-cell derived neurotrophic factor, sigma-1 receptors, phosphodiesterases, and nicotinic receptors. Further three targets could play a role to a lesser extent: NMDA receptors, 5-HT3 receptors, and potassium channels. Based on published clinical studies, traumatic brain injury, fatigue [e.g., in multiple sclerosis (MS)], and chorea in Huntington’s disease should be regarded potential, encouraging indications. Preclinical investigations suggest amantadine’s therapeutic potential in several further indications such as: depression, recovery after spinal cord injury, neuroprotection in MS, and cutaneous pain. Query in the database http://www.clinicaltrials.gov reveals research interest in several further indications: cancer, autism, cocaine abuse, MS, diabetes, attention deficit-hyperactivity disorder, obesity, and schizophrenia.
Mit der Entdeckung altersabhängiger epigenetischer Veränderungen, der DNA-Methylierung (DNAm), hat sich eine neue Möglichkeit aufgezeigt, das Alter eines Individuums zu schätzen. Die Methode wurde intensiv erforscht und ihre Anwendung in der forensischen Fallarbeit durch die Aktualisierung des § 81e der Strafprozessordnung (StPO) in Deutschland reguliert. Zur Untersuchung des DNAm-Grades müssen neue Techniken etabliert und validiert werden. Dies macht die Prüfung der Vergleichbarkeit von Messergebnissen aus verschiedenen forensischen Laboren erforderlich.
Hierzu führte die Arbeitsgruppe „Molekulare Altersschätzung“ der Deutschen Gesellschaft für Rechtsmedizin (DGRM) im Winter 2019/2020 den 2. Ringversuch (RV) zur quantitativen DNAm-Analyse mithilfe der Mini- und der Pyrosequenzierung durch. Dieser basierte auf den Erfahrungen des 1. RV 2018/2019, dessen Ergebnisse in dieser Ausgabe ebenfalls vorgestellt werden. Die aktuelle Studie umfasst Analyseergebnisse aus 12 Laboren (ingesamt 14 teilnehmende Labore), von denen einige beide Methoden angewandt haben. Zusätzlich führten 4 Labore eine Altersschätzung an den RV-Proben mit eigenen Markerkombinationen und Modellen durch. Da diese auf unterschiedlichen Referenzdaten und Markerkombinationen beruhen, erfolgte kein qualitativer Vergleich der Modelle, sondern das grundsätzliche Potenzial der Methodik wurde verdeutlicht. Ziele des RV waren die Evaluierung der Vergleichbarkeit der DNAm-Messungen und die Bewertung möglicher Einflussfaktoren, wie Extraktionsmethode und verwendetes Gerät.
Die Ergebnisse zeigen, dass sich die gemessenen DNAm-Werte der untersuchten Marker sowohl zwischen Mini- und Pyrosequenzierung als auch innerhalb der jeweiligen Methode zwischen den Laboren unterscheiden können, sodass mit Schwankungen gerechnet werden muss.
Die quantitative Analyse der relativen DNA-Methylierung gilt als eine der vielversprechendsten Methoden der molekularen Altersschätzung. Viele Studien der letzten Jahre identifizierten geeignete Positionen im Genom, deren DNA-Methylierung sich altersabhängig verändert. Für den Einsatz dieser Methode in der Routine- bzw. Fallarbeit ist es von großer Bedeutung, angewandte Analysetechniken zu validieren. Als ein Teilaspekt dieser Validierung sollte die Vergleichbarkeit der Analyseergebnisse zur DNA-Methylierung mithilfe der Mini- und Pyrosequenzierung zwischen verschiedenen Laboren evaluiert werden. Die Arbeitsgruppe „Molekulare Altersschätzung“ der Deutschen Gesellschaft für Rechtsmedizin (DGRM) führte hierzu den ersten, technischen Ringversuch durch, der 4 Positionen in den Genen PDE4C, EDARADD, SST und KLF14 umfasste. Diese Marker waren in vorangegangenen Studien als altersabhängige Biomarker charakterisiert worden. Am Ringversuch nahmen 12 Labore teil, wobei jedes die Wahl zwischen der Minisequenzierung und/oder der Pyrosequenzierung für die quantitative Methylierungsanalyse hatte. Jedem teilnehmenden Labor wurden Blut- und Speichelproben von 3 Personen unterschiedlichen Alters übersandt. Die Wahl der Reagenzien für die Probenbearbeitung wurde den Teilnehmern freigestellt.
Die Ergebnisse der Minisequenzierung zeigten systematische Abweichungen zwischen den Laboren, die am ehesten auf die Verwendung unterschiedlicher Reagenzien und Analyseplattformen zurückzuführen sein können. Die Resultate der Pyrosequenzierung hingegen wiesen nicht auf systematische Abweichungen zwischen den Laboren hin, hier zeigte sich jedoch die Tendenz einer markerabhängigen Abweichung. Darüber hinaus konnten Unterschiede hinsichtlich technischer Probleme zwischen Laboren mit mehr Erfahrung in der jeweiligen Sequenzierungsmethode und Laboren mit weniger Erfahrung festgestellt werden. Sowohl die Beobachtung von systematischen als auch die von markerabhängigen Abweichungen lässt den Schluss zu, dass eine Übertragung von Analysemethoden zwischen Laboren grundsätzlich möglich ist, eine Anpassung des jeweiligen Modells zur Altersschätzung jedoch notwendig sein kann.
Genome-wide association studies (GWAS) have identified more than 170 breast cancer susceptibility loci. Here we hypothesize that some risk-associated variants might act in non-breast tissues, specifically adipose tissue and immune cells from blood and spleen. Using expression quantitative trait loci (eQTL) reported in these tissues, we identify 26 previously unreported, likely target genes of overall breast cancer risk variants, and 17 for estrogen receptor (ER)-negative breast cancer, several with a known immune function. We determine the directional effect of gene expression on disease risk measured based on single and multiple eQTL. In addition, using a gene-based test of association that considers eQTL from multiple tissues, we identify seven (and four) regions with variants associated with overall (and ER-negative) breast cancer risk, which were not reported in previous GWAS. Further investigation of the function of the implicated genes in breast and immune cells may provide insights into the etiology of breast cancer.
The mechanisms behind carbon dioxide (CO2) dependency in non-autotrophic bacterial isolates are unclear. Here we show that the Staphylococcus aureus mpsAB operon, known to play a role in membrane potential generation, is crucial for growth at atmospheric CO2 levels. The genes mpsAB can complement an Escherichia coli carbonic anhydrase (CA) mutant, and CA from E. coli can complement the S. aureus delta-mpsABC mutant. In comparison with the wild type, S. aureus mps mutants produce less hemolytic toxin and are less virulent in animal models of infection. Homologs of mpsA and mpsB are widespread among bacteria and are often found adjacent to each other on the genome. We propose that MpsAB represents a dissolved inorganic carbon transporter, or bicarbonate concentrating system, possibly acting as a sodium bicarbonate cotransporter.
Traumatic spinal cord injuries result in impairment or even complete loss of motor, sensory and autonomic functions. Recovery after complete spinal cord injury is very limited even in animal models receiving elaborate combinatorial treatments. Recently, we described an implantable microsystem (microconnector) for low-pressure re-adaption of severed spinal stumps in rat. Here we investigate the long-term structural and functional outcome following microconnector implantation after complete spinal cord transection. Re-adaptation of spinal stumps supports formation of a tissue bridge, glial and vascular cell invasion, motor axon regeneration and myelination, resulting in partial recovery of motor-evoked potentials and a thus far unmet improvement of locomotor behaviour. The recovery lasts for at least 5 months. Despite a late partial decline, motor recovery remains significantly superior to controls. Our findings demonstrate that microsystem technology can foster long-lasting functional improvement after complete spinal injury, providing a new and effective tool for combinatorial therapies.
The NEDD8-activating enzyme (NAE) inhibitor MLN4924 inhibits cullin-RING ubiquitin ligase complexes including the SKP1-cullin-F-box E3 ligase βTrCP. MLN4924 therefore inhibits also the βTrCP-dependent activation of the classical and the alternative NFĸB pathway. In this work, we found that a subgroup of multiple myeloma cell lines (e.g., RPMI-8226, MM.1S, KMS-12BM) and about half of the primary myeloma samples tested are sensitized to TNF-induced cell death by MLN4924. This correlated with MLN4924-mediated inhibition of TNF-induced activation of the classical NFκB pathway and reduced the efficacy of TNF-induced TNFR1 signaling complex formation. Interestingly, binding studies revealed a straightforward correlation between cell surface TNFR1 expression in multiple myeloma cell lines and their sensitivity for MLN4924/TNF-induced cell death. The cell surface expression levels of TNFR1 in the investigated MM cell lines largely correlated with TNFR1 mRNA expression. This suggests that the variable levels of cell surface expression of TNFR1 in myeloma cell lines are decisive for TNF/MLN4924 sensitivity. Indeed, introduction of TNFR1 into TNFR1-negative TNF/MLN4924-resistant KMS-11BM cells, was sufficient to sensitize this cell line for TNF/MLN4924-induced cell death. Thus, MLN4924 might be especially effective in myeloma patients with TNFR1+ myeloma cells and a TNFhigh tumor microenvironment.
Meiotic chromosomes undergo rapid prophase movements, which are thought to facilitate the formation of inter-homologue recombination intermediates that underlie synapsis, crossing over and segregation. The meiotic telomere complex (MAJIN, TERB1, TERB2) tethers telomere ends to the nuclear envelope and transmits cytoskeletal forces via the LINC complex to drive these rapid movements. Here, we report the molecular architecture of the meiotic telomere complex through the crystal structure of MAJIN-TERB2, together with light and X-ray scattering studies of wider complexes. The MAJIN-TERB2 2:2 hetero-tetramer binds strongly to DNA and is tethered through long flexible linkers to the inner nuclear membrane and two TRF1-binding 1:1 TERB2-TERB1 complexes. Our complementary structured illumination microscopy studies and biochemical findings reveal a telomere attachment mechanism in which MAJIN-TERB2-TERB1 recruits telomere-bound TRF1, which is then displaced during pachytene, allowing MAJIN-TERB2-TERB1 to bind telomeric DNA and form a mature attachment plate.
Skeletal dysplasia with multiple dislocations are severe disorders characterized by dislocations of large joints and short stature. The majority of them have been linked to pathogenic variants in genes encoding glycosyltransferases, sulfotransferases or epimerases required for glycosaminoglycan synthesis. Using exome sequencing, we identify homozygous mutations in SLC10A7 in six individuals with skeletal dysplasia with multiple dislocations and amelogenesis imperfecta. SLC10A7 encodes a 10-transmembrane-domain transporter located at the plasma membrane. Functional studies in vitro demonstrate that SLC10A7 mutations reduce SLC10A7 protein expression. We generate a Slc10a7−/− mouse model, which displays shortened long bones, growth plate disorganization and tooth enamel anomalies, recapitulating the human phenotype. Furthermore, we identify decreased heparan sulfate levels in Slc10a7−/− mouse cartilage and patient fibroblasts. Finally, we find an abnormal N-glycoprotein electrophoretic profile in patient blood samples. Together, our findings support the involvement of SLC10A7 in glycosaminoglycan synthesis and specifically in skeletal development.
Natural light harvesting as well as optoelectronic and photovoltaic devices depend on efficient transport of energy following photoexcitation. Using common spectroscopic methods, however, it is challenging to discriminate one-exciton dynamics from multi-exciton interactions that arise when more than one excitation is present in the system. Here we introduce a coherent two-dimensional spectroscopic method that provides a signal only in case that the presence of one exciton influences the behavior of another one. Exemplarily, we monitor exciton diffusion by annihilation in a perylene bisimide-based J-aggregate. We determine quantitatively the exciton diffusion constant from exciton–exciton-interaction 2D spectra and reconstruct the annihilation-free dynamics for large pump powers. The latter enables for ultrafast spectroscopy at much higher intensities than conventionally possible and thus improves signal-to-noise ratios for multichromophore systems; the former recovers spatio–temporal dynamics for a broad range of phenomena in which exciton interactions are present.
Fanconi anemia (FA) is a genetically heterogeneous disorder with 22 disease-causing genes reported to date. In some FA genes, monoallelic mutations have been found to be associated with breast cancer risk, while the risk associations of others remain unknown. The gene for FA type C, FANCC, has been proposed as a breast cancer susceptibility gene based on epidemiological and sequencing studies. We used the Oncoarray project to genotype two truncating FANCC variants (p.R185X and p.R548X) in 64,760 breast cancer cases and 49,793 controls of European descent. FANCC mutations were observed in 25 cases (14 with p.R185X, 11 with p.R548X) and 26 controls (18 with p.R185X, 8 with p.R548X). There was no evidence of an association with the risk of breast cancer, neither overall (odds ratio 0.77, 95%CI 0.44–1.33, p = 0.4) nor by histology, hormone receptor status, age or family history. We conclude that the breast cancer risk association of these two FANCC variants, if any, is much smaller than for BRCA1, BRCA2 or PALB2 mutations. If this applies to all truncating variants in FANCC it would suggest there are differences between FA genes in their roles on breast cancer risk and demonstrates the merit of large consortia for clarifying risk associations of rare variants.
Auxin is a key regulator of plant growth and development, but the causal relationship between hormone transport and root responses remains unresolved. Here we describe auxin uptake, together with early steps in signaling, in Arabidopsis root hairs. Using intracellular microelectrodes we show membrane depolarization, in response to IAA in a concentration- and pH-dependent manner. This depolarization is strongly impaired in aux1 mutants, indicating that AUX1 is the major transporter for auxin uptake in root hairs. Local intracellular auxin application triggers Ca2+ signals that propagate as long-distance waves between root cells and modulate their auxin responses. AUX1-mediated IAA transport, as well as IAA- triggered calcium signals, are blocked by treatment with the SCFTIR1/AFB - inhibitor auxinole. Further, they are strongly reduced in the tir1afb2afb3 and the cngc14 mutant. Our study reveals that the AUX1 transporter, the SCFTIR1/AFB receptor and the CNGC14 Ca2+ channel, mediate fast auxin signaling in roots.
Surgical extrusion is a recognised treatment option for teeth that have insufficient coronal tooth structure remaining due to deep caries, resorption or traumatic injury. However, the technique has not been widely adopted, arguably because extraction of a severely compromised tooth may be difficult to achieve in a gentle and predictable way. In this paper, we present our novel approach to surgical extrusion and subsequent management of teeth using a vertical extraction system (Benex), which has become the method of choice in the authors' practice for many teeth that would otherwise be deemed unrestorable. We describe the clinical procedure in detail and discuss the advantages and disadvantages compared to alternative approaches, including surgical crown lengthening and orthodontic extrusion.
C9ORF72 mutations are the most common cause of familial frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS). MRI studies have investigated structural changes in C9ORF72-associated FTLD (C9FTLD) and provided first insights about a prominent involvement of the thalamus and the cerebellum. Our multicenter, 18F-fluorodeoxyglucose positron-emission tomography study of 22 mutation carriers with FTLD, 22 matched non-carriers with FTLD, and 23 cognitively healthy controls provided valuable insights into functional changes in C9FTLD: compared to non-carriers, mutation carriers showed a significant reduction of glucose metabolism in both thalami, underscoring the key role of the thalamus in C9FTLD. Thalamic metabolism did not correlate with disease severity, duration of disease, or the presence of psychotic symptoms. Against our expectations we could not demonstrate a cerebellar hypometabolism in carriers or non-carriers. Future imaging and neuropathological studies in large patient cohorts are required to further elucidate the central role of the thalamus in C9FTLD.
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that affects 1 in ~350 individuals. Genetic association studies have established ALS as a multifactorial disease with heritability estimated at ~61%, and recent studies show a prominent role for rare variation in its genetic architecture. To identify rare variants associated with disease onset we performed exome array genotyping in 4,244 cases and 3,106 controls from European cohorts. In this largest exome-wide study of rare variants in ALS to date, we performed single-variant association testing, gene-based burden, and exome-wide individual set-unique burden (ISUB) testing to identify single or aggregated rare variation that modifies disease risk. In single-variant testing no variants reached exome-wide significance, likely due to limited statistical power. Gene-based burden testing of rare non-synonymous and loss-of-function variants showed NEK1 as the top associated gene. ISUB analysis did not show an increased exome-wide burden of deleterious variants in patients, possibly suggesting a more region-specific role for rare variation. Complete summary statistics are released publicly. This study did not implicate new risk loci, emphasizing the immediate need for future large-scale collaborations in ALS that will expand available sample sizes, increase genome coverage, and improve our ability to detect rare variants associated to ALS.
Psychiatric disorders are thought to have a complex genetic pathology consisting of interplay of common and rare variation. Traditionally, pedigrees are used to shed light on the latter only, while here we discuss the application of polygenic risk scores to also highlight patterns of common genetic risk. We analyze polygenic risk scores for psychiatric disorders in a large pedigree (n ~ 260) in which 30% of family members suffer from major depressive disorder or bipolar disorder. Studying patterns of assortative mating and anticipation, it appears increased polygenic risk is contributed by affected individuals who married into the family, resulting in an increasing genetic risk over generations. This may explain the observation of anticipation in mood disorders, whereby onset is earlier and the severity increases over the generations of a family. Joint analyses of rare and common variation may be a powerful way to understand the familial genetics of psychiatric disorders.
MYC paralogs are frequently activated in small cell lung cancer (SCLC) but represent poor drug targets. Thus, a detailed mapping of MYC-paralog-specific vulnerabilities may help to develop effective therapies for SCLC patients. Using a unique cellular CRISPR activation model, we uncover that, in contrast to MYCN and MYCL, MYC represses BCL2 transcription via interaction with MIZ1 and DNMT3a. The resulting lack of BCL2 expression promotes sensitivity to cell cycle control inhibition and dependency on MCL1. Furthermore, MYC activation leads to heightened apoptotic priming, intrinsic genotoxic stress and susceptibility to DNA damage checkpoint inhibitors. Finally, combined AURK and CHK1 inhibition substantially prolongs the survival of mice bearing MYC-driven SCLC beyond that of combination chemotherapy. These analyses uncover MYC-paralog-specific regulation of the apoptotic machinery with implications for genotype-based selection of targeted therapeutics in SCLC patients.
Animals must slow or halt locomotion to integrate sensory inputs or to change direction. In Caenorhabditis elegans, the GABAergic and peptidergic neuron RIS mediates developmentally timed quiescence. Here, we show RIS functions additionally as a locomotion stop neuron. RIS optogenetic stimulation caused acute and persistent inhibition of locomotion and pharyngeal pumping, phenotypes requiring FLP-11 neuropeptides and GABA. RIS photoactivation allows the animal to maintain its body posture by sustaining muscle tone, yet inactivating motor neuron oscillatory activity. During locomotion, RIS axonal Ca2+ signals revealed functional compartmentalization: Activity in the nerve ring process correlated with locomotion stop, while activity in a branch correlated with induced reversals. GABA was required to induce, and FLP-11 neuropeptides were required to sustain locomotion stop. RIS attenuates neuronal activity and inhibits movement, possibly enabling sensory integration and decision making, and exemplifies dual use of one cell across development in a compact nervous system.
Obdach, Speisung und Heilung. Zur Geschichte des Seelhauses an der Juliuspromenade in Würzburg
(2023)
Das 1379 gestiftete Seelhaus befindet sich seit 1587 an der heutigen Juliuspromenade in Würzburg. Ursprünglich zur Beherbergung bedürftiger Reisender eingerichtet, entwickelte es sich seit dem 17. Jahrhundert zum Alterssitz für Mägde und Hausangestellte, bevor es im 19. Jahrhundert ganz aufgelöst wurde. Durch den Kauf der Hausnummern 9-11 durch die Oberzeller Schwestern 1927 erlebte sein karitativer Auftrag bis zur Zerstörung am 16. März 1945 eine Wiederbelebung.
Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) imposes a significant burden on Westernized regions. The Western diet, high in salt intake, significantly contributes to disease development. However, there are a lack of data on salt literacy and salt intake among MASLD patients in Germany. Our study aims to analyze daily salt intake and salt-intake-related behavior in MASLD patients. Methods: 234 MASLD patients were prospectively included. Daily salt intake and salt-intake-related behavior were assessed via a food frequency questionnaire (FFQ—DEGS) and a salt questionnaire (SINU). Statistical analyses were performed using SPSS. Results: Mean daily salt intake was higher in men than in women (7.3 ± 5 g/d vs. 5.3 ± 4 g/d; p < 0.001). There was significant agreement between increased daily salt intake (6 g/d) and the behavioral salt index (SI) (p < 0.001). Men exhibited higher SI scores compared to women, indicating lower awareness of salt in everyday life. Multivariate analysis identified specific salt-intake-related behaviors impacting daily salt consumption. Conclusions: Our study reveals a strong link between daily salt intake and salt-intake-related behavior, highlighting sex-specific differences in an MASLD cohort. To enhance patient care in high-cardiovascular-risk populations, specific behavioral approaches may be considered, including salt awareness, to improve adherence to lifestyle changes, particularly in male patients.
To define frailty in older cancer patients, the aim of this study was to assess the geriatric status and quality of life (QoL) aspects in patients suffering from recurrent/metastatic head and neck squamous cell carcinoma (r/m HNSCC) under palliative treatment. A comprehensive geriatric assessment (CGA) was performed on 21 r/m HNSCC patients at two defined assessments, and the QoL aspects and the impact of descriptive data were evaluated. The Kolmogorov–Smirnov test, Spearman’s rho correlation, and two-way mixed ANOVA were used for statistical analysis. All patients were found to be “frail”. Pain, fatigue, and the burden of illness were the highest-rated symptoms. Oral function and orofacial appearance were highly impaired. A significant impact of descriptive data on the CGA and QoL results was found (all p ≤ 0.05). Thus, the CGA results revealed high frailty, severe comorbidities, and high impairments in QoL aspects. The CGA and QoL results were negatively affected by the primary HNSCC treatment approach, the need for prosthetic treatment, and worse oral functional capacity. Therefore, frailty in r/m HNSCC patients seems to be multidimensional. The evaluation of the CGA and QoL aspects in r/m HNSCC patients can be recommended to detect special needs, organize aftercare, and improve the support for frail and vulnerable cancer patients to create a multidisciplinary treatment approach.
Sufficiently disordered metals display systematic deviations from the behavior predicted by semi-classical Boltzmann transport theory. Here the scattering events from impurities or thermal excitations can no longer be considered as additive-independent processes, as asserted by Matthiessen’s rule following from this picture. In the intermediate region between the regime of good conduction and that of insulation, one typically finds a change of sign of the temperature coefficient of resistivity, even at elevated temperature spanning ambient conditions, a phenomenology that was first identified by Mooij in 1973. Traditional weak coupling approaches to identify relevant corrections to the Boltzmann picture focused on long-distance interference effects such as “weak localization”, which are especially important in low dimensions (1D and 2D) and close to the zero-temperature limit. Here we formulate a strong-coupling approach to tackle the interplay of strong disorder and lattice deformations (phonons) in bulk three-dimensional metals at high temperatures. We identify a polaronic mechanism of strong disorder renormalization, which describes how a lattice locally responds to the relevant impurity potential. This mechanism, which quantitatively captures the Mooij regime, is physically distinct and unrelated to Anderson localization, but realizes early seminal ideas of Anderson himself, concerning the interplay of disorder and lattice deformations.
AbstractWater oxidation catalysis is a key step for sustainable fuel production by water splitting into hydrogen and oxygen. The synthesis of a novel coordination oligomer based on four Ru(bda) (bda = 2,2′‐bipyridine‐6,6′‐dicarboxylate) centers, three 4,4′‐bipyridine (4,4′‐bpy) linkers, and two 4‐picoline (4‐pic) end caps is reported. The monodispersity of this tetranuclear compound is characterized by NMR techniques. Heterogeneous electrochemical water oxidation after immobilization on multi‐walled carbon nanotubes (MWCNTs) shows catalytic performance unprecedented for this compound class, with a turnover frequency (TOF) of 133 s\(^{−1}\) and a turnover number (TON) of 4.89 × 10\(^6\), at a current density of 43.8 mA cm\(^{−2}\) and a potential of 1.45 V versus normal hydrogen electrode (NHE).
Herpesviruses have mastered host cell modulation and immune evasion to augment productive infection, life-long latency and reactivation thereof 1,2. A long appreciated, yet elusively defined relationship exists between the lytic-latent switch and viral non-coding RNAs 3,4. Here, we identify miRNA-mediated inhibition of miRNA processing as a thus far unknown cellular mechanism that human herpesvirus 6A (HHV-6A) exploits to disrupt mitochondrial architecture, evade intrinsic host defense and drive the lytic-latent switch. We demonstrate that virus-encoded miR-aU14 selectively inhibits the processing of multiple miR-30 family members by direct interaction with the respective pri-miRNA hairpin loops. Subsequent loss of miR-30 and activation of the miR-30/p53/Drp1 axis triggers a profound disruption of mitochondrial architecture. This impairs induction of type I interferons and is necessary for both productive infection and virus reactivation. Ectopic expression of miR-aU14 triggered virus reactivation from latency, identifying viral miR-aU14 as a readily drugable master regulator of the herpesvirus lytic-latent switch. Our results show that miRNA-mediated inhibition of miRNA processing represents a generalized cellular mechanism that can be exploited to selectively target individual members of miRNA families. We anticipate that targeting miR-aU14 provides exciting therapeutic options for preventing herpesvirus reactivations in HHV-6-associated disorders.
The Essential Climate Variable (ECV) Permafrost is currently undergoing strong changes due to rising ground and air temperatures. Surface movement, forming characteristic landforms such as rock glaciers, is one key indicator for mountain permafrost. Monitoring this movement can indicate ongoing changes in permafrost; therefore, rock glacier velocity (RGV) has recently been added as an ECV product. Despite the increased understanding of rock glacier dynamics in recent years, most observations are either limited in terms of the spatial coverage or temporal resolution. According to recent studies, Sentinel-1 (C-band) Differential SAR Interferometry (DInSAR) has potential for monitoring RGVs at high spatial and temporal resolutions. However, the suitability of DInSAR for the detection of heterogeneous small-scale spatial patterns of rock glacier velocities was never at the center of these studies. We address this shortcoming by generating and analyzing Sentinel-1 DInSAR time series over five years to detect small-scale displacement patterns of five high alpine permafrost environments located in the Central European Alps on a weekly basis at a range of a few millimeters. Our approach is based on a semi-automated procedure using open-source programs (SNAP, pyrate) and provides East-West displacement and elevation change with a ground sampling distance of 5 m. Comparison with annual movement derived from orthophotos and unpiloted aerial vehicle (UAV) data shows that DInSAR covers about one third of the total movement, which represents the proportion of the year suited for DInSAR, and shows good spatial agreement (Pearson R: 0.42–0.74, RMSE: 4.7–11.6 cm/a) except for areas with phase unwrapping errors. Moreover, the DInSAR time series unveils spatio-temporal variations and distinct seasonal movement dynamics related to different drivers and processes as well as internal structures. Combining our approach with in situ observations could help to achieve a more holistic understanding of rock glacier dynamics and to assess the future evolution of permafrost under changing climatic conditions.
The N,C-coupled naphthylisoquinoline alkaloid ancistrocladinium A belongs to a novel class of natural products with potent antiprotozoal activity. Its effects on tumor cells, however, have not yet been explored. We demonstrate the antitumor activity of ancistrocladinium A in multiple myeloma (MM), a yet incurable blood cancer that represents a model disease for adaptation to proteotoxic stress. Viability assays showed a potent apoptosis-inducing effect of ancistrocladinium A in MM cell lines, including those with proteasome inhibitor (PI) resistance, and in primary MM cells, but not in non-malignant blood cells. Concomitant treatment with the PI carfilzomib or the histone deacetylase inhibitor panobinostat strongly enhanced the ancistrocladinium A-induced apoptosis. Mass spectrometry with biotinylated ancistrocladinium A revealed significant enrichment of RNA-splicing-associated proteins. Affected RNA-splicing-associated pathways included genes involved in proteotoxic stress response, such as PSMB5-associated genes and the heat shock proteins HSP90 and HSP70. Furthermore, we found strong induction of ATF4 and the ATM/H2AX pathway, both of which are critically involved in the integrated cellular response following proteotoxic and oxidative stress. Taken together, our data indicate that ancistrocladinium A targets cellular stress regulation in MM and improves the therapeutic response to PIs or overcomes PI resistance, and thus may represent a promising potential therapeutic agent.
Background and objectives: Cartilage surgery constitutes a standard intervention in foot and ankle procedures. Currently, there is a lack of epidemiological data on its frequency, age distribution, and surgical options for cartilage surgery. This study aimed to investigate the current landscape of cartilage surgery in Germany and identify the most common procedures from an epidemiological standpoint. Materials and methods: Medical billing and reporting data from the Federal Statistical Office of Germany, encompassing the period 2006–2020, was examined, including all foot and ankle cartilage surgical procedures (summarized under OPS codes 5-812 and 5-801). The dataset incorporated information on the affected joint, patient age and sex, and surgery type. Each surgical procedure was categorized as “debridement”, “regeneration” or “refixation”. Linear and nonlinear regression analyses were employed, with a statistical significance threshold of 0.05. Results: From the total of 136,501 procedures conducted during the study period, the most frequently performed interventions were microfracture (58,252) and chondroplasty (56,135), and thus, debridement procedures were in the leading position. The use of acellular membranes was the most used regenerative technique (n = 11,414). At the ankle joint, interventions were mostly arthroscopic and in men, while foot cartilage surgeries were preferably performed via open surgery and mostly in women. Age distribution analysis revealed two primary peaks: the first in the 20–25-year-old group (ankle and foot) and the second in the 45–50-year-old group (ankle) and 55–60-year-old group (foot). Refixation and regenerative procedures were more frequent among younger individuals, while debriding procedures were more frequent among older individuals. Regenerative procedures, particularly in the ankle, significantly increased over time. Conclusions: Cartilage surgery of the foot and ankle was common, with two primary age groups predominantly affected. Notably, recent years have witnessed a considerable rise in cartilage regenerative procedures.
The use of bone-cement-enforced osteosynthesis is a growing topic in trauma surgery. In this context, drillability is a desirable feature for cements that can improve fracture stability, which most of the available cement systems lack. Therefore, in this study, we evaluated a resorbable and drillable magnesium-phosphate (MgP)-based cement paste considering degradation behavior and biocompatibility in vivo. Two different magnesium-phosphate-based cement (MPC) pastes with different amounts of phytic acid (IP 6) as setting retarder (MPC 22.5 and MPC 25) were implanted in an orthotopic defect model of the lateral femoral condyle of New Zealand white rabbits for 6 weeks. After explantation, their resorption behavior and material characteristics were evaluated by means of X-ray diffraction (XRD), porosimetry measurement, histological staining, peripheral quantitative computed tomography (pQCT), cone-beam computed tomography (CBCT) and biomechanical load-to-failure tests. Both cement pastes displayed comparable results in mechanical strength and resorption kinetics. Bone-contact biocompatibility was excellent without any signs of inflammation. Initial resorption and bone remodeling could be observed. MPC pastes with IP 6 as setting retardant have the potential to be a valuable alternative in distinct fracture patterns. Drillability, promising resorption potential and high mechanical strength confirm their suitability for use in clinical routine.
Innerhalb der Juvenilen Idiopathischen Arthritis (JIA) bilden Patienten mit Antinukleären Antikörpern (ANA) Subgruppen-übergreifend eine klinisch homogene Erkrankungsgruppe. Ob diesen klinischen Gemeinsamkeiten jedoch auch eine einheitliche Pathogenese zugrunde liegt, ist bisher unbekannt. Sogenannte periphere T-Helferzellen (TPH) spielen im Kontext zahlreicher Autoimmunerkrankungen eine entscheidende Rolle bei der Aktivierung autoreaktiver B-Zellen. Ziel dieser Arbeit war daher die phänotypische und funktionelle Analyse von PD-1hiCXCR5-CD4+ TPH-Zellen, sowie deren Verteilung in der Synovialflüssigkeit von Patienten unterschiedlicher Subgruppen der JIA.
Hierzu wurden Phänotyp und Zytokinprofil von PD-1hiCD4+ T-Zellen durchflusszytometrisch analysiert. Der funktionelle Einfluss von PD-1hiCD4+ T-Zellen auf die B-Zell-Differenzierung wurde mittels in vitro Kokulturen FACS-sortierter TPH-Zellen der Synovialflüssigkeit untersucht.
IL-21- und IL-17-produzierende T-Gedächtniszellen der Synovialflüssigkeit zeigten eine negative Korrelation zueinander. Die IL-21-Produktion ging besonders von PD-1hiCXCR5-HLA-DR+CD4+ T-Zellen aus, welche besonders in den Gelenken ANA-positiver JIA-Patienten akkumulierten. Diese Population zeigte phänotypische Ähnlichkeit mit TPH-Zellen und leistete in vitro effiziente B-Zell-Hilfe zu Plasmazelldifferenzierung und Immunglobulinsekretion, induzierte jedoch zudem einen CD21lo/-CD11c+T-bet+ Phänotyp in B-Zellen. Passend hierzu bestand auch ex vivo eine signifikante Korrelation zwischen TPH und CD21lo/-CD11c+T-bet+ doppelt-negativen B-Zellen (BDN).
Es konnte also die Expansion einer spezifischen T-Zellpopulation mit phänotypischen und funktionellen Charakteristika von TPH-Zellen beobachtet und deren funktioneller Zusammenhang mit CD21lo/-CD11c+T-bet+ BDN in der Synovialflüssigkeit von JIA-Patienten aufgezeigt werden. Dies könnte die Autoimmunantwort auf ubiquitäre Autoantigene innerhalb betroffener Gelenke ANA-positiver JIA-Patienten widerspiegeln.
Helically Twisted Graphene Nanoribbons: Bottom-up Stereospecific Synthesis and Characterization
(2024)
Over the past decade, substantial progress has been made in synthesizing atomically precise carbon nanostructures, with a focus on graphene nanoribbons (NRs) through advanced synthetic techniques. Despite these advancements, precise control over the stereochemistry of twisted NRs remains challenging. This thesis introduces a strategic approach to achieve absolute control over the single-handed helical conformation in a cove-edged NR, utilizing enantiopure [n]helicenes as a molecular wrench to intricately dictate the overall conformation of the NR.
Enantiopure [7]helicenes were stitched to the terminal K-regions of a conjugated pyrene NR using a stereospecific and site-selective palladium(II)-catalyzed annulative π-extension (APEX) reaction, resulting in a helically twisted NR with an end-to-end twist of 171°, the second-largest twist reported so far in the literature for twistacenes. The helical end-to-end twist increases with each addition of benzene ring to the central acene core, suggesting that the extra strain induced by the terminal [7]helicenes maintains such a high level of twist.
The quantum chemical calculations were conducted to investigate the impact of twisting on the conformational population. At room temperature, the central backbone of the nanoribbon adopts the twisted helicity opposite to that of the attached [7]helicene, constituting around 99% of the molecular population. For instance, (P)-[7]helicenes produce a left-handed helical nanoribbon, while (M)-[7]helicenes produce a right-handed helical nanoribbon. In the presence of helicenes of opposite chirality, the nanoribbon adopts a waggling conformation. The helically twisted nanoribbons are conformationally robust, as variable temperature chiroptical measurements showed no change in CD and CPL spectra. The proposed strategy, involving the late-stage addition of [n]helicene units through the APEX reaction, appears promising for streamlining the synthesis of diverse cove edge NR variants with desired conformations.
In addition to single-handed helically twisted nanoribbons, the symmetry-based functional properties of C2 and C1 symmetric pyrene-fused single and double [n]helicene compounds were studied. Owing to its higher structural rigidity, the C1 symmetric heptagonal ring-containing molecules exhibited exceptional configurational stability along with remarkable chiroptical properties compared to their C2 symmetric as well as pristine helicene congeners.
Sprech- und Stimmstörungen sind häufige Symptome der Idiopathischen Parkinson Erkrankung (IPS), wobei bis zu 89% der Patienten im Verlauf der Krankheit unter einer Dysarthrie leiden. Die Tiefenhirnstimulation des Nucleus subthalamicus (STN-DBS) ist eine etablierte Behandlung für die motorischen Symptome des IPS (Allert et al., 2004). Während STN-DBS positive Effekte auf einige Teilfunktionsbereiche der Dysarthrie zu haben scheint, berichten die meisten Studien entweder über keine Verbesserung oder eine Verschlechterung der Sprech- und Stimmfunktionen nach Implantation der STN-DBS (Tsuboi et al., 2015; Wang et al., 2003; Wertheimer et al., 2014). Klinische Erfahrungswerte sowie Fallberichte und Studien lassen vermuten, dass diese sprachtherapeutisch relevanten Nebenwirkungen unabhängig von der therapeutischen Wirksamkeit der STN-DBS sind und daher als unerwünschte, aber nicht therapieimmanente Interferenzfaktoren anzusehen sind (Bouthour et al., 2018), die es genauer zu untersuchen gilt, da die Lebensqualität von IPS-Erkrankten als stark einschränkend wahrgenommen wird (Hariz et al., 2010). Eine aufwendige und methodisch fundierte Klassifizierung wurde von Tsuboi und Kollegen vorgenommen, die im Zusammenhang mit STN-DBS fünf Cluster von Sprech- und Stimmstörungen identifizierten (Tanaka et al., 2020; Tsuboi et al., 2015, 2017). Dazu zählten die Phänotypen „spastische Dysarthrie“, „Stottern“, „rigid-hypokinetischer Typ“, „behauchte Stimme“ und „gepresste Stimme“.
Erste Hinweise lassen darauf schließen, dass die Nebenwirkungen von STN-DBS auf die Stimulation spezifischer Gehirnkreise zurückzuführen sein könnte (Fox et al., 2014). In dieser Arbeit wird eine retrospektive Studie mit STN-DBS stimulierten IPS Erkrankten vorgestellt, die sprachtherapeutisch relevante Sprech- und Stimmstörungen unter zwei Bedingungen bewertet (ein- und ausgeschaltete Stimulation) sowie eine prospektive Studie mit den beiden gleichen Bedingungen. Beide Studien haben das Ziel einer Replizierbarkeit der Ergebnisse von Tsuboi et al. (2015, 2017). Die zweite prospektive Studie bezieht außerdem konnektombasierte Daten ein.
Die Ergebnisse beider Studien lassen quantitativ keine Signifikanzen hinsichtlich der o.g. dysarthrischen Phänotypen zu, quantitativ lassen sich jedoch deutliche Tendenzen ähnlich der Ausgangsstudie erkennen. Zudem wurden das Cluster „Stottern“ in der retrospektiven Studie als weiteres möglicherweise STN-DBS immantentes Cluster identifiziert. In der prospektiven Studie wurde ein Cluster hinzugefügt, da in den Beurteilungen zusätzlich die Symptomatik „hasty speech“ oder auch „hastiges Sprechen“ beobachtet wurde.
The goal of this thesis was to investigate the influence of rotational restriction between individual parts and of the varying electron density in the bridging unit of D B A systems on the exchange interaction 2J, and thus the electronic coupling between a donor state and an acceptor state. A better understanding of how to influence the underlaying spin dynamics in such donor acceptor systems can open up the door to new technologies, such as modern molecular electronics or optoelectronic devices.
Therefore, three series of molecules consisting of a TAA electron donor, a TTC or ATC bridging unit and a PDI electron acceptor were studied. To investigate the influence of rotational restriction on 2J and the electronic coupling, a series of four rotationally hindered triads (chapter 6) was synthesised. The dihedral angle between the TAA and the TTC as well as between the TTC and the PDI was restricted by ortho methyl groups at the phenylene linkers of the connecting ends to the TTC bridge, producing a twist around the linking single bond which minimises the π overlap. The triads exhibit varying numbers of ortho methyl groups and therefore different degrees of rotational restriction. In order to shine light on the influence of varying electron density on 2J and the electronic coupling, a series of four substituted triptycene triads (chapter 7) was synthesised. The electron density in the TTC bridging unit was varied by electron donating and electron withdrawing groups in 12,13 position of the TTC bridging unit and thus varying its HOMO/LUMO energy. The last series of two anthracene bridge triads (chapter 8) connected both approaches by restricting the rotation with ortho methyl groups and simultaneously by varying the bridge energies.
In order to obtain the electronic properties, steady state absorption and emission spectra of all triads were investigated (chapter 4). Here, all triads show spectral features associated with the separate absorption bands of TAA and the PDI moiety. The reduced QYs, compared to the unsubstituted PDI acceptor, indicate a non radiative quenching mechanism in all triads. The CV data (chapter 5) were used to calculate the energies of possible CSSs and those results were used to assign the CR dynamics into the different Marcus regions. fs TA measurements reveal that all triads form a CSS upon excitation of the PDI moiety. The lifetimes of the involved states and the rate constants were determined by global exponential fits and global target analysis. The CR dynamics upon depopulation of the CSSs were investigated using external magnetic field dependent ns TA spectroscopy. The ns TA maps show that all triads recombine via CRT pathway populating the local 3PDI state in toluene and provided the respective lifetimes. The approximate QYs of triplet formation were determined using actinometry. The magnetic field dependent ns TA data reveal the exchange interaction 2J between singlet and triplet CSS for each triad. Those magnetic field dependent ns TA data in toluene were furthermore treated using a quantum mechanical simulation (done by U.E. Steiner) to extract the rate constants kT and kS for CRT and CRS, respectively. However, the error margins of kS were rather wide. Finally, the electronic couplings between the donor and the acceptor states were obtained by combining the aforementioned experimental results of the rate constants and applying the Bixon Jortner theoretical description of diabatic ET and Andersons perturbative theory of the exchange coupling. Therefore, the experimentally determined values of 2J and the calculated values of kCS and kT were used. The rate constant kS was calculated based on the electronic coupling V1CSS 1S0.
The rotationally hindered triads (chapter 6) show a strong influence of the degree of rotational restriction on the lifetimes and rate constants of the CS processes. The rate constants of CS are increasing with increasing rotational freedom. The magnetic field dependent decay data show that the exchange interactions increase with increasing rotational freedom. Based on the CR dynamics, the calculated electronic couplings of the ET processes reflect the same trend along the series. Here, only singlet couplings turned out to be strongly influenced while the triplet couplings are not. Therefore, this series shows that the ET dynamics of donor acceptor systems can strongly be influenced by restricting the rotational freedom.
In the substituted triptycene triads (chapter 7), decreasing electron density in the bridging unit causes a decrease of the CS rate constants. The magnetic field dependent decay data show that with decreasing electron density in the bridge the exchange interaction decreases. The CR dynamics-based rate constants and the electronic couplings follow the same trend as the exchange interaction. This series shows that varying the HOMO/LUMO levels of the connecting bridge between donor and acceptor strongly influences the ET processes.
In the anthracene bridge triads (chapter 8), the CS process is slow in both triads. The CR was fast in the anthracene triad and is slowed down in the methoxy substituted anthracene bridge triad. The increase of the exchange interaction with increasing electron density in the bridge was more pronounced than in the substituted triptycene triads. Thus, the variation of electron density in the bridge strongly influences the ET processes even though the rotation is restricted.
In this thesis, it was shown that the influence of the rotational hindrance as well as the electron density in a connecting bridge have strong influence on all ET processes and the electronic coupling in donor acceptor systems. These approaches can therefore be used to modify magnetic properties of new materials.
In a world of constant change, uncertainty has become a daily challenge for businesses. Rapidly shifting market conditions highlight the need for flexible responses to unforeseen events. Operations Management (OM) is crucial for optimizing business processes, including site planning, production control, and inventory management. Traditionally, companies have relied on theoretical models from microeconomics, game theory, optimization, and simulation. However, advancements in machine learning and mathematical optimization have led to a new research field: data-driven OM.
Data-driven OM uses real data, especially time series data, to create more realistic models that better capture decision-making complexities. Despite the promise of this new research area, a significant challenge remains: the availability of extensive historical training data. Synthetic data, which mimics real data, has been used to address this issue in other machine learning applications.
Therefore, this dissertation explores how synthetic data can be leveraged to improve decisions for data-driven inventory management, focusing on the single-period newsvendor problem, a classic stochastic optimization problem in inventory management.
The first article, "A Meta Analysis of Data-Driven Newsvendor Approaches", presents a standardized evaluation framework for data-driven prescriptive approaches, tested through a numerical study. Findings suggest model performance is not robust, emphasizing the need for a standardized evaluation process.
The second article, "Application of Generative Adversarial Networks in Inventory Management", examines using synthetic data generated by Generative Adversarial Networks (GANs) for the newsvendor problem. This study shows GANs can model complex demand relationships, offering a promising alternative to traditional methods.
The third article, "Combining Synthetic Data and Transfer Learning for Deep Reinforcement Learning in Inventory Management", proposes a method using Deep Reinforcement Learning (DRL) with synthetic and real data through transfer learning. This approach trains a generative model to learn demand distributions, generates synthetic data, and fine-tunes a DRL agent on a smaller real dataset. This method outperforms traditional approaches in controlled and practical settings, though further research is needed to generalize these findings.