Refine
Has Fulltext
- yes (22)
Year of publication
- 1999 (22) (remove)
Document Type
- Doctoral Thesis (17)
- Complete part of issue (2)
- Jahresbericht (1)
- Book (1)
- Master Thesis (1)
Keywords
- Molekulargenetik (3)
- Würzburg (3)
- Formicidae (2)
- Genexpression (2)
- Krebs (2)
- Maus (2)
- Molekularbiologie (2)
- Universität (2)
- Zeitschrift (2)
- AFLP (1)
- AP-PCR (1)
- Actin (1)
- Aktin-Zytoskelett (1)
- Aktivierung <Physiologie> (1)
- Ameisenstaat (1)
- Annual Report (1)
- Apoptose (1)
- Arthropoda (1)
- Atemwegswiderstand (1)
- Atta sexdens (1)
- Atta vollenweideri (1)
- BABLB/c (1)
- Bakterien (1)
- Bericht (1)
- Blattschneiderameisen (1)
- Bodyplethysmographie (1)
- C57/BL6 (1)
- Central Core Disease (1)
- Chaperone (1)
- Chromosom 11 (1)
- Chromosom 11p13 (1)
- Cofilin (1)
- DNA fingerprinting (1)
- DNA sequence analysis (1)
- DNA-Fingerprinting (1)
- DNA-Sequenzanalyse (1)
- DNS-Gyrase (1)
- DNS-Topoisomerasen (1)
- Delta (1)
- Demökologie (1)
- Diamiktit (1)
- Die Zeit (1)
- Differential Display PCR (1)
- Dipol-Dipol Wechselwirkung (1)
- Dipole potential (1)
- Dipole-dipole interaction (1)
- Dipolpotential (1)
- Dominanz (1)
- Drosophila melanogaster (1)
- Dwyka (1)
- Einzelhandel (1)
- Einzugsbereich (1)
- Einzugsgebiet <Raumordnung> (1)
- Entwicklung (1)
- Evolution (1)
- Expressionskartierung (1)
- Fernhandel (1)
- Fisch (1)
- Fischerella sp. (1)
- Flagellen (1)
- Fortpflanzungsverhalten (1)
- Fossil (1)
- Frankfurter Allgemeine (1)
- Funde (1)
- Generalisierung (1)
- Genidentifizierung (1)
- Genkartierung (1)
- Geochemie (1)
- Geologie (1)
- Geologische Kartierung (1)
- Geschichte 1100-1600 (1)
- Geschichte 1988 (1)
- Geschichte 900-1300 (1)
- Grenzflächenpotenzial (1)
- Hafenstadt (1)
- Helicobacter pylori (1)
- Helicobacter-pylori-Infektion (1)
- Hormos (1)
- IOS (1)
- Impedanz (1)
- Impuls-Oszillometrie (1)
- In situ Hybridisierung (1)
- Insecta (1)
- Interkasten (1)
- Iran (1)
- Jahresbericht (1)
- Jungfernzeugung (1)
- Karbon (1)
- Karoo (1)
- Kartierung (1)
- Kohlendioxid (1)
- Koloniegründung (1)
- Koloniestruktur (1)
- Kondensation (1)
- Koppelungsanalyse (1)
- Langmuir Adsorptionsisotherme (1)
- Langmuir adsorption isotherm (1)
- Legiolysin (1)
- Legionella pneumophila (1)
- Lichtschutz (1)
- Lipide (1)
- Listeria monocytogenes (1)
- Literarische Wertung (1)
- Literaturkritik (1)
- Lymphozytentransformation (1)
- M cells (1)
- M-Zelle (1)
- M-Zellen (1)
- Malignant Hyperthermia (1)
- Maligne Hyperthermie (1)
- Mapping (1)
- Melanom (1)
- Mensch (1)
- Mesenchym (1)
- Methode (1)
- Mikrosatelliten (1)
- Mitose (1)
- Mittelalter (1)
- Morphologie (1)
- Mouse (1)
- Muskelkrankheit (1)
- Mustererkennung (1)
- Musterlernen (1)
- Nama (1)
- Namibia (1)
- Neurogenese (1)
- Niere (1)
- Normwerte für Kinder (1)
- Oberflächendruck (1)
- Oberflächenpotential (1)
- Oranje (1)
- PAC contig (1)
- PAC-Contig (1)
- PI3-Kinase (1)
- PI3-kinase (1)
- Paarungshäufigkeit (1)
- Parameterextraktion (1)
- Pathogenität (1)
- Pathogenitätsinsel (1)
- Permokarbon (1)
- Peyer's Patches (1)
- Peyer'sche Plaques (1)
- Phloretin (1)
- Physiologie (1)
- Pigmentierung (1)
- Playa (1)
- Ponerinae (1)
- Populationsgenetik (1)
- Präkambrium (1)
- Reaktanz (1)
- Report (1)
- Resistanz (1)
- Rezeptortyrosinkinase (1)
- Ryanodin-Rezeptor Gen (1)
- Ryanodine receptor gene (1)
- Salmonella typhimurium (1)
- Schwermineral (1)
- Schwertkärpfling (1)
- Seehandel (1)
- Seelandfernhandel (1)
- Sensillum ampullaceum (1)
- Siedlungsarchäologie (1)
- Somitogenese (1)
- Standortanalyse (1)
- Standortplanung (1)
- Strahlentherapie (1)
- Surface potential (1)
- Surface pressure (1)
- Süddeutsche Zeitung (1)
- T cell activation (1)
- T-Lymphozyt (1)
- T-Zell-Aktivierung (1)
- Taufliege (1)
- Thelytokie (1)
- Tillit (1)
- Tonstein (1)
- Topoisomerase II alpha (1)
- Transkription (1)
- Tuff (1)
- Tumor (1)
- University Library (1)
- Universitätsbibliothek (1)
- Urogenitalsystem (1)
- Vereisung (1)
- Virulenz (1)
- Virulenzfaktoren (1)
- Visuelle Wahrnehmung (1)
- Wahrnehmung (1)
- Wertung (1)
- Wuerzburg (1)
- Wurzburg (1)
- Xiphophorus (1)
- Xmrk (1)
- Zentralfibrillen-Myopathie (1)
- actin cytoskeleton (1)
- airway resistance (1)
- apoptosis (1)
- bodyplethysmography (1)
- cDNA Selektion (1)
- cDNA selection (1)
- carbon dioxide (1)
- centrosomal protein (1)
- chaperones (1)
- chromosome 11p13 (1)
- cofilin (1)
- colony founding (1)
- colony structur (1)
- condensation (1)
- congenital myopathy (1)
- development (1)
- differential display PCR (1)
- dominance (1)
- evaluation (1)
- evolution (1)
- exon trapping (1)
- expression mapping (1)
- fishes (1)
- flagella (1)
- gene identification (1)
- generalization (1)
- genomic sequencing (1)
- genomische Sequenzierung (1)
- glaciation (1)
- impedance (1)
- impulse oscillometry (1)
- in situ hybridization (1)
- intercastes (1)
- kidney (1)
- kongenitale Myopathie (1)
- light protection (1)
- linkage analysis (1)
- literary criticism (1)
- mapping (1)
- mating frequency (1)
- mesenchyme (1)
- microsatellites (1)
- mitosis (1)
- morphology (1)
- mouse (1)
- neurogenesis (1)
- neuronal filter (1)
- neuronales Filter (1)
- non-Disjunktion (1)
- non-disjunction (1)
- p-Hydroxyphenylpyruvat-Dioxygenase (1)
- p-hydroxyphenylpyruvate dioxygenase (1)
- parameter extraction (1)
- pathogenicity island (1)
- pattern conditioning (1)
- pigmentation (1)
- population genetics (1)
- reactance (1)
- receptor tyrosine kinase (1)
- reference values for children (1)
- reproductive competition (1)
- reproductive skew (1)
- reproductive success (1)
- reproduktive Konkurrenz (1)
- reproduktiver Erfolg (1)
- resistance (1)
- sensillum ampullaceum (1)
- sensorische Ökologie (1)
- sensory ecology (1)
- social insects (1)
- somitogenesis (1)
- soziale Insekten (1)
- thelytoky (1)
- topoisomerase II alpha (1)
- transcription (1)
- urogenital system (1)
- virulence factors (1)
- visiual pattern recognition (1)
- visuelle Mustererkennung (1)
- zentrosomales Protein (1)
- Ökologie (1)
Institute
- Theodor-Boveri-Institut für Biowissenschaften (11)
- Universität Würzburg (2)
- Institut für Geographie (1)
- Institut für Geographie und Geologie (1)
- Institut für Geologie (1)
- Institut für Humangenetik (1)
- Institut für Medizinische Strahlenkunde und Zellforschung (1)
- Institut für Molekulare Infektionsbiologie (1)
- Institut für deutsche Philologie (1)
- Kinderklinik und Poliklinik (1)
Food borne pathogens that cause systemic disease must cross the intestinal barrier. Many of these pathogens, eg Salmonella typhimurium and Shigella flexneri, use M cells, found only within the follicle associated epithelium (FAE) that overlies Peyer’s patches and other lymphoid follicles, to enter the host. This study is primarily an investigation into the interaction of S. typhimurium and Listeria monocytogenes with the intestinal epithelium, representing the early stage of an infection.
The mode of action of phloretin and its analogs on the permeability of natural membranes for neutral and charged molecules, such as urea, glucose and chloride has been characterized 25 years ago. In contrast to signal molecules with primary effects on transport systems of natural membranes, phloretin also affects model membranes, i.e., artificial membranes, which do not contain proteins. Since the dipole potential reducing effect of phloretin on mono- and bilayers has been found, it became clear that its primary effect must be a biophysical one: phloretin adsorbs to lipid layers and changes biophysical parameters of these layers. The aim of this work was the characterization of the interaction between the surface-active molecule phloretin and artificial lipid layers. We were able to describe structural and functional parameters of the model systems mono- and bilayer as functions of one or few variables. One of these parameters, the dipole potential, measured as a function of the aqueous phloretin concentration, allowed a critical examination of the Langmuir adsorption model that has been postulated for the interaction between phloretin and lipid layers. Surface pressure versus area per lipid molecule isotherms and surface (dipole) potential change versus area per lipid molecule isotherms, measured at lipid monolayers, allowed a structural description of the phloretin-lipid interaction: phloretin integrates into monolayers dependent on the surface pressure and the phase state of the lipid. Calorimetric measurements confirmed the integration of phloretin into membranes because of the strong decrease of the phase transition temperature, but they also showed that the cooperativity of phase transition is hardly affected, even at very high amounts of phloretin in the membrane. Obviously the interaction between phloretin and lipids is restricted to the head groups, an integration into the hydrocarbon layer is unlikely. 2H NMR measurements with spherical unilamellar vesicles of headgroup-deuterated lipid showed changed quadrupolar splittings indicating the interaction between phloretin and headgroups of the lipids.