Refine
Has Fulltext
- yes (80)
Is part of the Bibliography
- yes (80) (remove)
Year of publication
Document Type
- Journal article (68)
- Book article / Book chapter (6)
- Conference Proceeding (4)
- Review (2)
Keywords
- Toxikologie (68)
- DNA (6)
- DNA binding (5)
- Genotoxicity (5)
- Carcinogen (4)
- Carcinogenesis (3)
- Carcinogens (3)
- Ernährung (3)
- Medizin (3)
- Aflatoxin (2)
- Ames test (2)
- Benzene (2)
- DNA Binding (2)
- Dose response (2)
- Dose-response relationship (2)
- Estrogen (2)
- Hormone (2)
- binding (2)
- carcinogen (2)
- (Rat liver) (1)
- (Salmonella) (1)
- 1 (1)
- 2-Acetylaminofluorene (1)
- 2-Dichloroethane (1)
- 2-acetylaminofluorene (1)
- 4'-hydroxylation (1)
- 4-(p-nitrobenzyl)pyridine (1)
- 8-Hydroxy-deoxyguanosine (1)
- Aflatoxin B1 (1)
- Alkylation (1)
- Amino acid composition (1)
- Amino acids (1)
- Aminosäuren (1)
- Anabolieagent (1)
- Aniline derivatives (1)
- Anthraquinone glycosides (1)
- Aryl hydrocarbon rnonooxygenase (1)
- Benzo(a)pyrene-DNA binding (1)
- Cancer prevention (1)
- Carcinogen risk Individual susceptibili (1)
- Carcinogenic potency (1)
- Carcinogenicity (1)
- Carcinogenität (1)
- Chemical carcinogenesis (1)
- Choline deficiency (1)
- Chromosome aberration (1)
- Covalent DNA binding (1)
- Covalent binding (1)
- Covalent binding index (1)
- Covalent binding index - Diethylstilbestrol (1)
- Cytochrome b5 (1)
- DNA binching (1)
- DNA damage (1)
- DNA methylation (1)
- DNA-Binding (1)
- DNS-Bindung (1)
- Electrophiles (1)
- Emodin (1)
- Endogenous genotoxicity (1)
- Enzyme induction (1)
- Epoxide hydrolase (1)
- Estrone (1)
- Gastric carcinogenesis (1)
- Genetic instability (1)
- Glutathione Stransferase (1)
- Immunization (1)
- Inhalation (1)
- Krebs (1)
- Krebs <Medizin> (1)
- MammaJian mutagenicity test (1)
- Mechanism of action (1)
- Metabolic activation (1)
- Metabolism saturation (1)
- Micronucleus test (1)
- Mutagenicity assay (1)
- Mutagens (1)
- Mutation assay (1)
- N-methyl-N-nitrosourea (1)
- Nitrosation (1)
- Nitrosierung (1)
- Oxygen radical (1)
- Pointmutation (1)
- Protein binding (1)
- Protein coding (1)
- Quantitative risk assessment (1)
- Radicals (1)
- Rat (1)
- Rat Iiver microsomes (1)
- Rat liver peroxisome (1)
- Reactive intermediates (1)
- Riot control agents (1)
- Risikoanalyse (1)
- Risk estimation (1)
- Salmonella typhimurium (1)
- Salmonella/microsome assay (1)
- Sensitivity (1)
- Short-term Carcinogenicity Test (1)
- Short-term tests (1)
- Spontaneous tumours (1)
- Structureactivity relationship (1)
- Styrol (1)
- Thymidine glycol (1)
- Toluene (1)
- Transgenic mouse (1)
- Transgenie mice (1)
- Trenbolone (1)
- Tritiated Water (1)
- Zellteilung (1)
- adduct (1)
- aflatoxin (1)
- aflatoxin B1 (1)
- alkylation (1)
- allelic variant (1)
- amine (1)
- amino acid (1)
- covalent (1)
- covalent binding (1)
- cytochrome P450 2C9 (1)
- diet (1)
- dose (1)
- endogenous (1)
- ethanol (1)
- extrapolation (1)
- genotoxic (1)
- heterogeneous population (1)
- impact pharmacogenetics (1)
- in vivo (1)
- individual (1)
- liver microsomes (1)
- mutagen (1)
- natural (1)
- nitrosation (1)
- nitroso compound (1)
- o-Chlorobenzylidene malononitrile (1)
- risk (1)
- stomach (1)
- susceptibility (1)
- tolbutamide substrate (1)
- tumour (1)
- urea (1)
- warfarin polymorphisms (1)
Institute
- Institut für Pharmakologie und Toxikologie (80) (remove)
Male Fischer F-344 rats were given ethanol in the drinking water and/or by single oral administration. Following this, the animals received p.o. 100 ng/kg of the hepatocarcinogen eHJaflatoxin BI (AFBI)' 24 h later, the level of DNA-bound AFBI was determined in the liver and was found not to be affected by any type of ethanol pretreatment. A cocarcinogenic effect of ethanol in the liver is therefore unlikely to be due to an effect on the metabolic activation and inactivation processes governing the formation of DNA-binding AFBI metabolites.