Refine
Has Fulltext
- yes (83)
Is part of the Bibliography
- yes (83)
Year of publication
- 2012 (83) (remove)
Document Type
- Journal article (51)
- Doctoral Thesis (32)
Language
- English (83) (remove)
Keywords
- Biologie (9)
- Drosophila (4)
- Taufliege (4)
- expression (4)
- protein (4)
- vaccinia virus (4)
- Apoptosis (3)
- Melanom (3)
- Myc (3)
- Vaccinia-Virus (3)
- combination therapy (3)
- differentiation (3)
- melanoma (3)
- oncolytic virotherapy (3)
- onkolytische Virotherapie (3)
- Apoptose (2)
- Ausbreitung (2)
- Evolution (2)
- Geruchssinn (2)
- Hey (2)
- Integrated network analysis (2)
- Knockout <Molekulargenetik> (2)
- Learning (2)
- Lernen (2)
- MAP-Kinase (2)
- Molekulargenetik (2)
- Netzwerkanalyse (2)
- Onkolyse (2)
- Sinnesphysiologie (2)
- Systembiologie (2)
- Thrombozyt (2)
- african trypanosomes (2)
- apoptosis (2)
- architecture (2)
- brain (2)
- c-myc (2)
- cancer (2)
- dispersal (2)
- diversity (2)
- functional characterization (2)
- immunoreactive neurons (2)
- localization (2)
- lung cancer (2)
- melanogaster (2)
- olfactory memory (2)
- oncolysis (2)
- receptor (2)
- resistance (2)
- transcription (2)
- A-type lamins (1)
- AMP (1)
- AMPK (1)
- Actin nucleation (1)
- Actin-bindende Proteine (1)
- Advanced snowmelt (1)
- Aktinnukleation (1)
- Alps (1)
- Alzheimer Dementia (1)
- Alzheimer-Krankheit (1)
- Amazonia (1)
- Ameisen (1)
- Amyloid <beta-> (1)
- Aneuploidie (1)
- Anoikis (1)
- Anthrax toxin (1)
- Anämie (1)
- Araneae (1)
- Areal (1)
- BBCH (1)
- BRAF (1)
- BRCA1 positive (1)
- BRCA1/2 negative (1)
- BRCA2 positive (1)
- Bacillus anthracis (1)
- Black lipid bilayer (1)
- Blochmannia (1)
- Blutbildendes Gewebe (1)
- Blutplättchen (1)
- Bre (1)
- Bre-knockout (1)
- CENP-A (1)
- CSE4, CENP-A (1)
- Camponotus (1)
- Camponotus floridanus (1)
- Circadian Rhythms (1)
- Circadiane Rhythmik (1)
- Climate change (1)
- Cortison (1)
- DNA Reparatur (1)
- DNA repair (1)
- DNA replication (1)
- DNA-binding vesicles (1)
- DNS-Reparatur (1)
- DOT1 (1)
- Database (1)
- Datenbank (1)
- Datenbanksystem (1)
- Decision-making (1)
- Delayed snowmelt (1)
- Diabetes mellitus (1)
- Duftintensität (1)
- EF-1A (1)
- ERK signaling (1)
- Eierstockkrebs (1)
- Embryonale Stammzelle (1)
- Embryonalentwicklung (1)
- Endogenous Glucocorticoids (1)
- Entscheidung (1)
- Epigenese (1)
- Epigenetic (1)
- Erythropoietin (1)
- European beech (1)
- Extrazelluläre Matrix (1)
- Fanconi Anemia (1)
- Fanconi Anämie (1)
- Flowering (1)
- Fluoreszenzmikrosopie (1)
- Functional interaction (1)
- Functional module search (1)
- Functional modules (1)
- Funktionelle Modulsuche (1)
- GATA4 (1)
- Gedächtnis (1)
- Gen (1)
- Gen notch (1)
- Genregulation (1)
- Geschmack (1)
- Geschmackssinn (1)
- Gesundheitswesen (1)
- Gliom (1)
- Glioma (1)
- HRAS (1)
- Herbivor-Parasitoid Interaktion (1)
- Herz (1)
- Herzentwicklung (1)
- Hochauflösendes Verfahren (1)
- Humorale Immunität (1)
- Imd pathway (1)
- Insulinrezeptor (1)
- Insulinsignalweg (1)
- Integrated Knowledgebase (1)
- Integrierte Datenbank (1)
- Interaktion (1)
- Intrazelluläre Symbiose (1)
- Invasion (1)
- Japankärpfling (1)
- Kerntransport (1)
- Knorpelzelle (1)
- Kombinationstherapie (1)
- Krebs <Medizin> (1)
- LMNA mutations (1)
- Lamto Reserve (1)
- Land use (1)
- Landnutzung (1)
- Landschaft (1)
- Lin9 (1)
- Lipidmembran (1)
- Lungenkrebs (1)
- MAP3K4 (1)
- MYC (1)
- Management System (1)
- Management-Systeme (1)
- Mass Isotopomers Distribution Analysis (1)
- Massen-Isotopomer Verteilungs-Analyse (1)
- Maus (1)
- Medizin (1)
- Memory (1)
- Messenger-RNS (1)
- Metabolic Flux Analysis (1)
- Metabolic pathways (1)
- Metabolic profiles (1)
- Metabolische Flux-Analyse (1)
- Metastase (1)
- Microarray (1)
- Milnesium tardigradum (1)
- Mitose (1)
- Miz1 (1)
- Modell (1)
- Mycoplasma (1)
- Nervendegeneration (1)
- Network Analysis (1)
- Netzwerkalgorithmen (1)
- Neurobiologie (1)
- Neurodegeneration (1)
- New Zealand (1)
- Next generation sequencing (1)
- Nicht-kleinzelliges Bronchialkarzinom (1)
- Non-Small Cell Lung Cancer (1)
- Odour Intensity (1)
- Olfaction (1)
- Olfactory (1)
- Ovarialkarzinom (1)
- Ovarian Cancer (1)
- P15(INK4B) (1)
- P21 (1)
- PALM (1)
- POZ domain (1)
- Parasit (1)
- Perception (1)
- Persistenz (1)
- Phosphoproteomic analysis (1)
- Photorezeption (1)
- Physiology (1)
- Platelets (1)
- Plättchennetzwerk (1)
- Plättchenphosphoproteom (1)
- Polyomaviren (1)
- Polyomavirus JC (1)
- Pore (1)
- Porenbildung (1)
- Protein p53 (1)
- Proteinkinasen (1)
- Proteomanalyse (1)
- Proteome (1)
- Prozessierung (1)
- QDTI (1)
- RNA (1)
- Raf kinases (1)
- Repression <Genetik> (1)
- Rho (1)
- Rüsselkäfer (1)
- SWI/SNF (1)
- Salmonella enterica (1)
- Salmonella-containing vacuole (1)
- Savanna (1)
- Sensory (1)
- Signalkette (1)
- Similarity (1)
- Simkania Negevensis (1)
- Simulation (1)
- Software (1)
- Spezialisierung (1)
- Spir (1)
- Spitzwegerich (1)
- Stat5 (1)
- Stoffwechsel (1)
- Strahlentherapie (1)
- Sumo (1)
- Sumoylierung (1)
- Synapse (1)
- Systems Biology (1)
- T cells (1)
- TNF-R1 (1)
- TNF-R2 (1)
- Taste (1)
- Therapie (1)
- Tiergesellschaft (1)
- Toxin (1)
- Translokation (1)
- Trend test (1)
- Tumor-Nekrose-Faktor <alpha> (1)
- Vaccinia Virus Replikation (1)
- Verbreitungsgrenzen (1)
- Verhalten (1)
- WISP1/CCN4 (1)
- Wahrnehmung (1)
- West Africa (1)
- Yolk protein (1)
- Zeitdifferenzierung (1)
- Zelladhäsion (1)
- Zelldifferenzierung (1)
- abdominal (1)
- acoustic communication (1)
- actin cortex (1)
- adaption (1)
- adult bee (1)
- adult drosophila (1)
- agonist (1)
- alagille syndrome (1)
- alignment (1)
- aminoacyl-transfer-RNA (1)
- amyloid beta (1)
- anemia (1)
- aneuploidy (1)
- animal communication (1)
- anoikis (1)
- ant communities (1)
- anthropogenic noise (1)
- antimicrobial (1)
- ants (1)
- aortic-valve (1)
- arabidopsi (1)
- arabidopsis thaliana (1)
- arabidpsis thaliana (1)
- arf (1)
- auditory masking (1)
- autophagy (1)
- axial skeletal defects (1)
- bacterial persistence (1)
- balance (1)
- bee larva (1)
- big brown bats (1)
- bilayers (1)
- binding (1)
- biogenic amines (1)
- bitter taste (1)
- blood-stream forms (1)
- blowfly calliphora-vomitoria (1)
- brucei (1)
- burned savanna (1)
- caenorhabditis elegans (1)
- call (1)
- cancer cells (1)
- cancer-cells (1)
- canine cancer therapy (1)
- canopy fogging (1)
- capsid protein (1)
- cardiac aging (1)
- cardiac fibrosis (1)
- cell adhesion (1)
- cell surface (1)
- cell-cycle arrest (1)
- cell-cycle regulation (1)
- centomeres (1)
- central-nervous-system (1)
- centromere (1)
- cerebral ischemia (1)
- chain (1)
- chalinolobus-tuberculatus (1)
- chemosensory protein (1)
- chemosensory system (1)
- chemotherapy (1)
- chromatin (1)
- circadian photoreception (1)
- classification (1)
- clock (1)
- cluster (1)
- colony-stimulating factor (1)
- conjugate (1)
- connector (1)
- containing neurons (1)
- contralateral breast cancer (1)
- conversion (1)
- corticotropin-releasing hormone (1)
- courtship displays (1)
- crosstalk (1)
- cultivation (1)
- cytokine (1)
- dSTORM (1)
- dart-poison frog (1)
- database (1)
- decision making (1)
- defective Mitosis (1)
- dependent magnetosensitvity (1)
- depth (1)
- detoxified lipooligosaccharide (1)
- disease (1)
- dosage (1)
- drosophila embryo (1)
- drosophila melanogaster (1)
- drosophila mushroom body (1)
- drug (1)
- dwelling bat (1)
- dynamics (1)
- elementary mode analysis (1)
- elongation (1)
- embryonic stem cells (1)
- engineering (1)
- environment (1)
- eptesicus-fuscus (1)
- erythropoietin (1)
- eucera berlandi (1)
- evolution (1)
- expressed sequence tag (1)
- expression signature (1)
- factor 1-alpha (1)
- factor EEF1A2 (1)
- feeding behavior (1)
- fehlerhafte Mitose (1)
- fission yeast (1)
- flagellar (1)
- flagellum (1)
- fluorescent protein (1)
- forest (1)
- forest disturbance (1)
- forest soils (1)
- fruit fly (1)
- gamma (1)
- gene (1)
- genes (1)
- genetics (1)
- gradient (1)
- growing escherichia coli (1)
- haemolymph (1)
- head involution (1)
- heart development (1)
- hemophilus influenzae (1)
- herbivore-parasitoid interaction (1)
- higher pitch (1)
- hindbrain boundary (1)
- histidine kinase (1)
- homology modeling (1)
- honey bee (1)
- honey bees (1)
- honeybees (1)
- host cell death (1)
- human jagged1 (1)
- hydrodynamics (1)
- hymenoptera (1)
- hyper-IL-6 (1)
- identification (1)
- immune response (1)
- immunity (1)
- in-vivo (1)
- individual-based simulation (1)
- induction (1)
- infected bee (1)
- ingle-molecule microscopy (1)
- inhibitor (1)
- insect immunity (1)
- insulin pathway (1)
- insulin receptor (1)
- interacting species (1)
- interaction (1)
- interaktive Arten (1)
- internal transcribed spacer 2 (1)
- ionizing radiation (1)
- isthmic oragnizer (1)
- knock-out mouse (1)
- laminopathies (1)
- land use (1)
- landscape (1)
- larva (1)
- learning performances (1)
- life-span regulation (1)
- light avoidance (1)
- long-term reuse (1)
- long-term-memory (1)
- mRNA processing (1)
- malaria (1)
- male bees (1)
- malignant melanoma (1)
- mammalian CRY1 (1)
- mammalian cells (1)
- markers (1)
- mass spectometry (1)
- mass spectrometry (1)
- mechanism (1)
- medaka (1)
- memory (1)
- mesenchymal stem cells (1)
- mesenchymale Stammzellen (1)
- metabolic flux (1)
- metabolism (1)
- metastasis (1)
- methylene blue (1)
- miR-22 (1)
- miRNA (1)
- mice (1)
- microRNA (1)
- microRNAs (1)
- microarray (1)
- microscopy (1)
- mimecan (1)
- model (1)
- models (1)
- modules (1)
- molecular systematics (1)
- moth manduca sexta (1)
- motility (1)
- mouse (1)
- multiparticle collision dynamics (1)
- mushroom bodies (1)
- mutations (1)
- nasopharyngeal colonization (1)
- neobellieria bullata (1)
- netcar-feeding bats (1)
- neural crest (1)
- neuronal differentiation (1)
- neuronale Differenzierung (1)
- neurons form (1)
- nicotinic acetylcholine-receptors (1)
- nuclear envelope (1)
- nuclear lamina (1)
- nuclear organization (1)
- nuclear transport (1)
- nucleosome (1)
- nucleotide exchange (1)
- nyctalus noctula (1)
- obstructive pulmonary disease (1)
- oncolytic therapy (1)
- oncolytic virus (1)
- ophrys heldreichii (1)
- organization (1)
- organogenesis (1)
- oscillator (1)
- osteoblast differentiation (1)
- osteoglycin (1)
- otitis media (1)
- p53 (1)
- pathway (1)
- peptide (1)
- perception (1)
- persistierende Infektion (1)
- pesticides (1)
- phagocytosis (1)
- phagosomalescape (1)
- phylogenetic tree (1)
- phylogeny (1)
- pollination (1)
- polyarcylamide gels (1)
- polymorphism (1)
- pore formation and translocation (1)
- probes (1)
- promoter (1)
- propagation (1)
- propulsion (1)
- protein docking (1)
- protein familiy (1)
- protein-interaction networks (1)
- proteins (1)
- pseudomas-syringae (1)
- quali-chick chimeras (1)
- rain forest (1)
- range formation (1)
- rat calyx (1)
- recolonization (1)
- reconstruction (1)
- regulation (1)
- relative abundance (1)
- relevance (1)
- resolution (1)
- response regulator (1)
- reward (1)
- rhythm (1)
- ribosomal RNA (1)
- ribwort plantain (1)
- richtersius coronifer (1)
- root (1)
- rs112587690 (1)
- rs12628 (1)
- rural domain (1)
- sample (1)
- savanna woodland (1)
- schizosaccaromyces-pombe (1)
- secondary structure (1)
- senescence (1)
- sensitization (1)
- sensor (1)
- sequence alignment (1)
- sequestration (1)
- serotonin (1)
- set (1)
- sexual deception (1)
- signal peptides (1)
- signal transduction (1)
- signals (1)
- simulation (1)
- social calls (1)
- soil macrofauna (1)
- solvent (1)
- sonic hedghog (1)
- specialization (1)
- species composition (1)
- species richness (1)
- species richness estimation (1)
- spiroplasma (1)
- sptPALM (1)
- stability (1)
- staphylococcus aureus (1)
- stocks (1)
- sumo (1)
- sumoylation (1)
- superoxide-dismutase (1)
- superresolution (1)
- surface (1)
- survival (1)
- symbiosis (1)
- synthetic biology (1)
- tardigrada (1)
- target molecule (1)
- tergite (1)
- term memory (1)
- tolerance (1)
- toxicity (1)
- tracking (1)
- traffic noise (1)
- transcription activation (1)
- transcription factor (1)
- transcription factor MIZ-1 (1)
- transcriptome (1)
- transmission (1)
- trinervitermes (1)
- true diversity (1)
- trypanosome lytic factor (1)
- tumor suppressor (1)
- type 2 diabetes mellitus (1)
- tyrosine phosphorylation (1)
- ubiquitin (1)
- ultrastructure (1)
- unpaired median neurons (1)
- vaccine (1)
- vaccinia virus replication (1)
- variants (1)
- vibrio cholerae (1)
- virulence (1)
- viscosity (1)
- vitellogenin (1)
- water stress (1)
- work bee (1)
- worker bee larva (1)
- young work bee (1)
- Ähnlichkeit (1)
Institute
- Theodor-Boveri-Institut für Biowissenschaften (83) (remove)
Introduction: While it has been reported that the risk of contralateral breast cancer in patients from BRCA1 or BRCA2 positive families is elevated, little is known about contralateral breast cancer risk in patients from high risk families that tested negative for BRCA1/2 mutations.
Methods: A retrospective, multicenter cohort study was performed from 1996 to 2011 and comprised 6,235 women with unilateral breast cancer from 6,230 high risk families that had tested positive for BRCA1 (n = 1,154) or BRCA2 (n = 575) mutations or tested negative (n = 4,501). Cumulative contralateral breast cancer risks were calculated using the Kaplan-Meier product-limit method and were compared between groups using the log-rank test. Cox regression analysis was applied to assess the impact of the age at first breast cancer and the familial history stratified by mutation status.
Results: The cumulative risk of contralateral breast cancer 25 years after first breast cancer was 44.1% (95%CI, 37.6% to 50.6%) for patients from BRCA1 positive families, 33.5% (95%CI, 22.4% to 44.7%) for patients from BRCA2 positive families and 17.2% (95%CI, 14.5% to 19.9%) for patients from families that tested negative for BRCA1/2 mutations. Younger age at first breast cancer was associated with a higher risk of contralateral breast cancer. For women who had their first breast cancer before the age of 40 years, the cumulative risk of contralateral breast cancer after 25 years was 55.1% for BRCA1, 38.4% for BRCA2, and 28.4% for patients from BRCA1/2 negative families. If the first breast cancer was diagnosed at the age of 50 or later, 25-year cumulative risks were 21.6% for BRCA1, 15.5% for BRCA2, and 12.9% for BRCA1/2 negative families.
Conclusions: Contralateral breast cancer risk in patients from high risk families that tested negative for BRCA1/2 mutations is similar to the risk in patients with sporadic breast cancer. Thus, the mutation status should guide decision making for contralateral mastectomy.