Refine
Has Fulltext
- yes (831) (remove)
Year of publication
- 2012 (831) (remove)
Document Type
- Journal article (373)
- Doctoral Thesis (373)
- Complete part of issue (48)
- Preprint (8)
- Report (8)
- Book (4)
- Book article / Book chapter (4)
- Jahresbericht (3)
- Review (3)
- Conference Proceeding (2)
Keywords
- Würzburg (50)
- Universität (46)
- Wuerzburg (44)
- Wurzburg (44)
- Medizin (43)
- University (42)
- hadron-hadron scattering (15)
- Biologie (13)
- Psychologie (12)
- melanoma (10)
Institute
- Theodor-Boveri-Institut für Biowissenschaften (94)
- Universität Würzburg (47)
- Graduate School of Life Sciences (43)
- Fakultät für Physik und Astronomie (39)
- Klinik und Poliklinik für Psychiatrie, Psychosomatik und Psychotherapie (28)
- Medizinische Klinik und Poliklinik I (28)
- Institut für Psychologie (27)
- Physikalisches Institut (27)
- Neurologische Klinik und Poliklinik (25)
- Institut für Molekulare Infektionsbiologie (24)
Sonstige beteiligte Institutionen
Background If detected in time, delayed cerebral vasospasm after aneurysmal subarachnoid hemorrhage (SAH) may be treated by balloon angioplasty or chemical vasospasmolysis in order to enhance cerebral blood flow (CBF) and protect the brain from ischemic damage. This study was conceived to compare the diagnostic accuracy of detailed neurological examination, Transcranial Doppler Sonography (TCD), and Perfusion-CT (PCT) to detect angiographic vasospasm. Methods The sensitivity, specificity, positive and negative predictive values of delayed ischemic neurological deterioration (DIND), pathological findings on PCT- maps, and accelerations of the mean flow velocity (MVF) were calculated. Results The accuracy of DIND to predict angiographic vasospasm was 0.88. An acceleration of MFV in TCD (>140 cm/s) had an accuracy of 0.64, positive PCT-findings of 0.69 with a higher sensitivity, and negative predictive value than TCD. Interpretation Neurological assessment at close intervals is the most sensitive and specific parameter for cerebral vasospasm. PCT has a higher accuracy, sensitivity and negative predictive value than TCD. If detailed neurological evaluation is possible, it should be the leading parameter in the management and treatment decisions. If patients are not amenable to detailed neurological examination, PCT at regular intervals is a helpful tool to diagnose secondary vasospasm after aneurysmal SAH.