Refine
Has Fulltext
- yes (134)
Is part of the Bibliography
- yes (134)
Year of publication
Document Type
- Journal article (120)
- Conference Proceeding (9)
- Book article / Book chapter (5)
Keywords
- Physiologische Chemie (43)
- Schwertkärpfling (18)
- Xiphophorus (6)
- evolution (5)
- melanoma (5)
- Gen (4)
- Krebs <Medizin> (4)
- Onkogen (4)
- Tumor (4)
- medaka (4)
- Lebendgebärende Zahnkarpfen (3)
- Protein-Tyrosin-Kinasen (3)
- genome (3)
- genomics (3)
- meiosis (3)
- sex chromosomes (3)
- transcriptome (3)
- Biologie (2)
- DM-domain gene (2)
- DNS (2)
- Entstehung (2)
- Fingerprint-Verfahren (2)
- Fische (2)
- In vivo (2)
- Japankärpfling (2)
- Mc4r (2)
- Melanom (2)
- Umweltfaktor (2)
- Y chromosome (2)
- cancer (2)
- developmental biology (2)
- evolutionary genetics (2)
- fish (2)
- fish model (2)
- gametogenesis (2)
- gene expression (2)
- genome annotation (2)
- microRNA (2)
- parthenogenesis (2)
- piRNA (2)
- preexisting bias (2)
- puberty (2)
- recombination (2)
- reproductive success (2)
- sequence alignment (2)
- sex determination (2)
- sex differentiation (2)
- sexual selection (2)
- synaptonemal complex (2)
- testis (2)
- transposable elements (2)
- zebrafish (2)
- 5-methylcytosine (1)
- Acipenser baerii (1)
- Amazon Molly (1)
- Annotation (1)
- Aulonocara (1)
- BMP signaling (1)
- Biology (1)
- Buntbarsche (1)
- Carcinogenese (1)
- Cell-line (1)
- Co-option (1)
- Coahuila (1)
- CrossQuery (1)
- Cynoglossus semilaevis (1)
- DMRT1 (1)
- DNA fingerprinting (1)
- DNA-binding proteins (1)
- Danio-rerio (1)
- Dmrt1bY (1)
- Drosophila melanogaster (1)
- Egfr (1)
- Embryo (1)
- Embryonalentwicklung (1)
- Enhancer (1)
- Epidermaler Wachstumsfaktor-Rezeptor (1)
- Eukaryoten (1)
- Fish (1)
- Freeze-etching (1)
- Förster Resonance Energy Transfer (1)
- Gene expression analysis (1)
- Genetik (1)
- Genome (1)
- Genome assembly (1)
- Genome comparison (1)
- Genomics (1)
- Gentransfer (1)
- Germline (1)
- Gewebe (1)
- Goldbrasse (1)
- Human (1)
- Humangenetik (1)
- In vitro (1)
- Isoenzym (1)
- Jmjd6 (1)
- Karyotyp (1)
- Konservierung (1)
- Krebsforschung (1)
- Latimeria menadoensis (1)
- Ligand <Biochemie> (1)
- Male intromittent organ (1)
- Malignant melanoma (1)
- Medaka - Genetransfer - Transient expression - DNA fate - Fish developmental biology (1)
- Medizin (1)
- Megalobrama amblycephala (1)
- Melanoma (1)
- Messenger-RNS (1)
- Microarray data (1)
- Modell (1)
- Molekularbiologie (1)
- NGS (1)
- Nervenzelle (1)
- Niedere Wirbeltiere (1)
- Njassasee (1)
- PCR (1)
- PI3K (1)
- Pain (1)
- Perugia-Kärpfling (1)
- Physiologie (1)
- Pigmentmuster (1)
- Poecilia (Teleostei: Poeciliidae) (1)
- Poeciliid fish (1)
- Promotor (1)
- Protoonkogen (1)
- Protopterus annectens (1)
- RAS (1)
- RNA-SEQ data (1)
- RNA-Seq (1)
- RNA-seq transcriptome (1)
- RT -PCR (1)
- RTK (1)
- Recombinant DNA ; Growth hormone gene ; PCR; Silver carp ; Fish (1)
- Recombinant DNA ; polymerase chain reaction ; metallothionein gene ; rainbow trout ; fish (1)
- SGNH hydrolase (1)
- SMAD signaling (1)
- SOX9 (1)
- Schwertkräpfling (1)
- Sex chromosome (1)
- Sex determination (1)
- Sexual development and function (1)
- Single nucleotide change (1)
- Somatotropin (1)
- Sox5 (1)
- Sparus aurata (1)
- Spongilla lacustris (1)
- Sprouting angiogenesis (1)
- Squalius alburnoides (1)
- Synaptische Vesikel (1)
- Synaptophysin (1)
- Süßwasserpolypen (1)
- Transcription (1)
- Transcriptomic (1)
- Transgene Tiere (1)
- Transmission electron microscopy (1)
- Transposable element (1)
- Tumorzelle (1)
- Ultrastruktur (1)
- Veracruz <Stadt> (1)
- Wachstum (1)
- X. couchianus (1)
- X. hellerii (1)
- Xiphophorus fish (1)
- Y chromosome degeneration (1)
- Zebrafish (1)
- achiasmatic (1)
- acipenserid minisatellite (1)
- adaptive evolution (1)
- adaptive radiation (1)
- all-fish genes (1)
- amphimixis (1)
- androgen-induced masculinization (1)
- apomixis (1)
- automixis (1)
- beetle horns (1)
- cancer genomics (1)
- cancer models (1)
- cell fusion (1)
- cell proliferation (1)
- cellline transfection (1)
- chain reaction (1)
- chemotherapy resistance (1)
- chimera formation (1)
- chimeric RTKs (1)
- coloration (1)
- comparative genomics (1)
- contributes (1)
- copy-number alteration (1)
- crossing-over (1)
- crosstalk (1)
- cultures (1)
- determination locus (1)
- determining genes (1)
- deuterostomes (1)
- differentiation (1)
- dimorphic expression (1)
- divergent expression regulation (1)
- dmrt1 (1)
- drug selection (1)
- embryonic stem-cells (1)
- energy homeostasis (1)
- epidermal growth factor receptor (1)
- evolutionary biology (1)
- evolutionary mutant model (1)
- exaptation (1)
- expression (1)
- expression analysis (1)
- factor acetylhydrolase activity (1)
- fishes Xiphophorus (1)
- fluorescence lifetime imaging microscopy (1)
- gene (1)
- gene duplications (1)
- gene prediction (1)
- gene regulatory network evolution (1)
- generation (1)
- genetic markers (1)
- genetic oscillators (1)
- genome assembly (1)
- genome cells (1)
- genomic analysis (1)
- genomic organization (1)
- genus Xiphophorus (1)
- gonadal development (1)
- gonopodium (1)
- growth (1)
- growth hormone gene (1)
- gut microflora (1)
- gynogeaesls (1)
- gynogenesis (1)
- helitron (1)
- herbivorous diet (1)
- heterochromatin (1)
- heterogamety (1)
- human genomics (1)
- hybrid origin (1)
- hybridogenesis (1)
- in-vitro (1)
- intermuscular bone (1)
- introgressive hybridization (1)
- key innovation (1)
- kinase inhibitors (1)
- knockout (1)
- likelihood approach (1)
- linkage map (1)
- luciferase (1)
- lungfish (1)
- male size polymorphism (1)
- male-specific traits (1)
- malignant tumors (1)
- master sex-determining gene (1)
- medaka fish (1)
- medakafish oryzias latipes (1)
- melanogenesis (1)
- metastatic melanoma (1)
- miR-146a (1)
- miR-193a (1)
- mini-exon (1)
- mitochondrial DNA (1)
- mitochondrial genome (1)
- molecular biology (1)
- molecular evolution (1)
- molecular mechanisms (1)
- molecular phylogeny (1)
- monodelphis domestica (1)
- mouse (1)
- mouse testis differentiation (1)
- mullerian hormone AMH (1)
- natural variation (1)
- oogenesis (1)
- oreochromis niloticus (1)
- oryzias latipes (1)
- oryzias-latipes (1)
- ovary (1)
- paralogs (1)
- parten-offspring conflict (1)
- pigment pattern (1)
- platelet activation factor (1)
- platyfish (1)
- pluripotency (1)
- poeciliid fishes (1)
- poeciliidae (1)
- polymerase (1)
- polyploidy (1)
- pp6oc-src (1)
- ras (1)
- receptor tyrosine kinase (1)
- regulatory regions (1)
- reproductive character displacement (1)
- retinoic acid (1)
- retrotransposons (1)
- rolling-circle transposons (1)
- sarcopterygian fish (1)
- satellite DNA (1)
- sex chromosome evolution (1)
- sex combs (1)
- sex linked pigmentation pattern (1)
- sex-determining gene (1)
- sex-determining region (1)
- sexual antagonistic genes (1)
- sexual conflict (1)
- sexually antagonistic genes (1)
- simple repeat sequences (1)
- simple repetitive sequences (1)
- size polymorpbism (1)
- small RNA-sequencing (1)
- sodal domlnance (1)
- species diversification (1)
- spermatogenesis (1)
- squalius alburnoides (1)
- stage III (1)
- sturgeon (1)
- sturgeon karyotype (1)
- swordtails (1)
- tandem repeats (1)
- teleost fish (1)
- teleost fishes (1)
- teleost flsh (1)
- teleostei (1)
- testosterone (1)
- topminnow (1)
- transcriptional rewiring (1)
- transgenic fish (1)
- transplantation (1)
- transposition (1)
- tree selection (1)
- variant detection (1)
- vertebrates (1)
- whole genome (1)
- whole genome duplication (1)
- whole genome duplications (1)
- whole-genome duplication (1)
- whole-genome sequencing (1)
- xiphophorus maculatus (1)
Institute
The melanoma inducing locus of Xiphophorus encodes a tumorigenic version of a novel putative receptor tyrosine kinase (Xmrk). To elucidate the mechanism of oncogenic activation of Xmrk, we compared the structure and expression of two oncogenic loci with the corresponding proto-oncogene. Only minor structural alterations were found to be specific for the oncogenic Xmrk genes. Marked overexpression of the oncogene transcripts in melanoma, which are approximately 1 kb shorter than the proto-oncogene transcript, correlates with the malignancy of the tumors. The tumor transcripts are derived from an alternative transcription start site that is used only in the oncogenic loci. Thus, oncogenic activation of the melanoma inducing Xmrk gene appears primarily to be due to novel transcriptional control and overexpression.
Melanoma formation in the teleost Xiphophorus is caused by a dominant genetic locus, Tu. This locus includes the Xmrk oncogene, which encodes a receptor tyrosine kinase. Tumor induction is. suppressed in wild-type fish by a tumor suppressor locus, R. Molecular genetic analyses revealed that the Tu locus emerged by nonhomologaus recombination of the Xmrk proto-oncogene with a previously uncharacterized sequence, D. This event generated an additional copy of Xmrk with a new promoter. Suppression of the new Xmrk promoter by R in parental fish and its deregulation in hybrids explain the genetics of melanoma formation in Xiphophorus.