Refine
Has Fulltext
- yes (310)
Is part of the Bibliography
- yes (310) (remove)
Year of publication
- 2024 (3)
- 2023 (8)
- 2022 (29)
- 2021 (34)
- 2020 (29)
- 2019 (18)
- 2018 (2)
- 2017 (4)
- 2016 (15)
- 2015 (3)
- 2014 (2)
- 2013 (3)
- 2012 (3)
- 2011 (2)
- 2010 (2)
- 1994 (20)
- 1993 (9)
- 1992 (10)
- 1991 (9)
- 1990 (11)
- 1989 (10)
- 1988 (10)
- 1987 (9)
- 1986 (11)
- 1985 (6)
- 1984 (3)
- 1983 (6)
- 1982 (4)
- 1981 (3)
- 1980 (3)
- 1979 (4)
- 1978 (4)
- 1977 (1)
- 1976 (1)
- 1975 (4)
- 1974 (1)
- 1973 (8)
- 1972 (3)
- 1971 (1)
- 1968 (1)
- 1967 (1)
Document Type
- Journal article (310) (remove)
Keywords
- Organische Chemie (122)
- Chemie (9)
- 1 (8)
- fluorescence (8)
- water oxidation (8)
- 3 (7)
- polycyclic aromatic hydrocarbons (7)
- self-assembly (7)
- RNA (6)
- organic chemistry (6)
- photocatalysis (6)
- Diels-Alder reactions (5)
- SARS-CoV-2 (5)
- dyes (5)
- luminescence (5)
- chemistry (4)
- circular dichroism (4)
- in vitro selection (4)
- perylene bisimide (4)
- sphingolipids (4)
- structure elucidation (4)
- supramolecular chemistry (4)
- 4-0xadiazin-6-ones (3)
- absolute configuration (3)
- aggregation (3)
- aromaticity (3)
- artificial photosynthesis (3)
- boranes (3)
- catalysis (3)
- cell imaging (3)
- ceramide (3)
- ceramides (3)
- chirality (3)
- dyes/pigments (3)
- exciton coupling (3)
- homogeneous catalysis (3)
- kinetics (3)
- liquid crystals (3)
- macrocycles (3)
- molecular docking (3)
- organic photodiodes (3)
- photoinduced electron transfer (3)
- 2 (2)
- 4-0xadiazine-2-carboxylate (2)
- 6 (2)
- Anorganische Chemie (2)
- Carbocations (2)
- Chili RNA Aptamer (2)
- Deoxyribozymes (2)
- Design (2)
- Dyes (2)
- Enol Iactones (2)
- Epitranscriptomics (2)
- Fluorescence (2)
- G-quadruplexes (2)
- Holothuria spinifera (2)
- J‐aggregates (2)
- Ketenes (2)
- LC-HRESIMS (2)
- RNA modification (2)
- RNA-dependent RNA polymerase (2)
- Ruthenium complexes (2)
- UV/Vis spectroscopy (2)
- absorption (2)
- acid sphingomyelinase (2)
- annulation (2)
- azulene (2)
- boronate esters (2)
- cage compounds (2)
- cerebrosides (2)
- chirality transfer (2)
- click chemistry (2)
- corannulene (2)
- crystal engineering (2)
- cyclophanes (2)
- cytotoxic activity (2)
- cytotoxicity (2)
- density functional calculations (2)
- dynamic covalent chemistry (2)
- electrocatalysis (2)
- energy transfer (2)
- fullerenes (2)
- helicenes (2)
- heterogeneous catalysis (2)
- hexahydro- (2)
- homogenous catalysis (2)
- hydrogen bonding (2)
- lysosome (2)
- marine natural product (2)
- merocyanines (2)
- methyl 6-oxo-5-phenyl- (2)
- nanographene (2)
- optical spectroscopy (2)
- organic semiconductors (2)
- organic solar cells (2)
- pentacene (2)
- perylene bisimides (2)
- phosphorescence (2)
- polymerization (2)
- polymers (2)
- preparation (2)
- renewable fuels (2)
- ruthenium (2)
- ruthenium bda complexes (2)
- ruthenium complexes (2)
- singlet oxygen (2)
- site-specific RNA cleavage (2)
- solid-state emitters (2)
- solvent effects (2)
- spectroscopy (2)
- squaraine dyes (2)
- stereochemistry (2)
- streptomyces (2)
- thermodynamics (2)
- two-photon absorption (2)
- two-photon excited fluorescence (2)
- water (2)
- water splitting (2)
- y-oxo- (2)
- 0]hexane (1)
- 1' -c]naphthalene (1)
- 1-aryl- (1)
- 1-dibromo-1a (1)
- 10 (1)
- 11-dihydro- / 1-Pyrazoline (1)
- 2-Bismethylenecyclobutanes (1)
- 2-Bismethylenecyclohexane (1)
- 2-Cyclopentanedione derivatives (1)
- 2-Norcaranols (1)
- 2-photon absorption (1)
- 2-α:2' (1)
- 3-Azabicyclo{3 (1)
- 3-Methenonaphthalenes (1)
- 3-aryl- (1)
- 3-cyclohexadiene (1)
- 3-n-butyl-N-phenyl- (1)
- 4 (1)
- 4-Pentadienylamine (1)
- 4-tetrahydro- (1)
- 4</sup>.0<sup>3 (1)
- 4]0xadiazino[4 (1)
- 4]non-7-en-6-ylpotassium (1)
- 4a (1)
- 5 (1)
- 5-b]isoquinolin-1-one derivatives (1)
- 5-dinitrobenzoates (1)
- 5</sup>]beptanes (1)
- 5H-Dibenzo[a (1)
- 5]cyclohepta[ 1 (1)
- 6-Norpinanols (1)
- 6-Norpinyl 3 (1)
- 6-Thiatricyclo[3.2.1.o 2.7 ]oct-3-ene 6 (1)
- 6-aryl- (1)
- 6-dibromo-3-phenyl- (1)
- 6-dioxide (1)
- 6-phenyl (1)
- 6H-1 (1)
- 6a-Tetrahydro-2H-cyclobuta[b]pyrans (1)
- 7 (1)
- 7-Norcaranylidene carbenoid (1)
- 7-dibromo (1)
- 7</sup>]heptane derivatives (1)
- 7b-tetrahydro- (1)
- 8 (1)
- 8-Tetrahydro-3H-2-benzopyrans (1)
- 8a-Tetrahydro-2H-1-benzopyran (1)
- ADME analysis (1)
- AIE (1)
- API (1)
- Adipic acid (1)
- Aldehyde Bioconjugation (1)
- Alkyltransferase Ribozyme SAMURI (1)
- Allenes (1)
- Alzheimer′s disease (1)
- Amplification (1)
- Anchimeric assistance in solvolysis (1)
- Ancistrocladus ealaensis (1)
- Ancistrocladus likoko (1)
- Antiviral nucleoside analogues (1)
- Apoptosis (1)
- Aromatic-hydrocarbon (1)
- Aspergillus niger (1)
- Atomic and molecular interactions with photons (1)
- Auflösungsraten (1)
- BMP-2 (1)
- BMP-2 delivery (1)
- Bacillus megaterium (1)
- Baltic Sea (1)
- Barbaralane derivatives (1)
- Benzocycloheptene derivatives (1)
- Bicyclo[1.1.0]butane derivatives (1)
- Bicyclo[1.1.0]butanes (1)
- Bicyclo[1.1.0]butylcarbinyl sulfonates (1)
- Bicyclo[2.1.l]hexan-5-one (1)
- Bicyclo[3.2.0.0<sup>2 (1)
- Bicyclo[3.2.0]hept-6-ene derivatives (1)
- Bicyclo[3.2.1]oct-3-en-2-yl anions (1)
- Biochemistry (1)
- Biocompatibility (1)
- Biodegradable polymer scaffolds (1)
- Bioorthogonal Tag (1)
- Bisbenzo[ 4 (1)
- Bone morphogenetic protein-2 (1)
- Bone tissue engineering (1)
- Butadien (1)
- C-13 NMR (1)
- C-C coupling (1)
- CCL2 (MCP-1) (1)
- CD4+ T cells (1)
- CD8+ T cells (1)
- CXCL8 (IL-8) (1)
- Caco-2 (1)
- Carbene insertion (1)
- Carbon (1)
- Ceramide (1)
- Chemical modification (1)
- Chiralität (1)
- Chromophore Assembly (1)
- Chromophores (1)
- Co-Crystal Structures of Chili RNA (1)
- Conjugated polymers (1)
- Corannulene (1)
- Cryoelectron Microscopy (1)
- Cryoelectron microscopy (1)
- Cycloadditions (1)
- Cycloallene dimerization (1)
- Cyclobuta[c}pyridines (1)
- Cyclobutylcarbinyl sulfonates (1)
- Cyclohept-3-en-1-ols (1)
- Cyclopropanetetracarbonitrile derivatives (1)
- DNA (1)
- DNA catalysis (1)
- DNA/RNA binding (1)
- DNA/RNA sensors (1)
- DNS-Schädigung (1)
- Deoxyribozyme (1)
- Dictyota (1)
- Dictyotaceae (1)
- Dimers (1)
- Donor−acceptor dyads (1)
- EPR (1)
- Effectors in plant pathology (1)
- Electron (1)
- Electron demand in ditosylates (1)
- Electron transfer (1)
- Emission (1)
- Energy transfer (1)
- Enzymes (1)
- Eriodictyon californicum (1)
- FT-IR spectroscopy (1)
- Festkörper-NMR (1)
- Fiels-effect transistors (1)
- Fluorescence and Crosslinking (1)
- Fluoreszenz (1)
- Fluoreszenzresonanz-Energietransfer (1)
- Fluorogenic RNA Aptamers (1)
- Functional nucleic acids (1)
- Functionalization (1)
- Fungal host response (1)
- Garcinia biflavonoids (1)
- Gibbs activation energy (1)
- Glycosyltransferase (1)
- Golgi (1)
- Graphene nanoribbons (1)
- Growth; BMP-2 (1)
- H2A histone family member X (H2AX) (1)
- HIV (1)
- HRMS (1)
- Halonium ions (1)
- Helicen (1)
- High efficiency (1)
- High performance (1)
- Homo Diels-Alder reactions (1)
- Homoaromaticity in carbanions (1)
- Homobenzvalene (1)
- Hyperfine coupling constants (1)
- In-vitro (1)
- Indirect and direct contributions to A<sub>iso</sub> (1)
- Influence of excitation classes (1)
- Intensity (1)
- Isomorphe Nukleobasen-Analoga (1)
- Isoquinolines (1)
- J-aggregate behavior (1)
- J-aggregates (1)
- Jurkat cells (1)
- K-region (1)
- K2–K model (1)
- Koordinationsisomerie (1)
- Lactone conformations (1)
- Lectins (1)
- Light-emitting diodes (1)
- Line-shape analysis (1)
- Lippert–Mataga plot (1)
- Liquid-crystalline (1)
- Long-range coupling constants (1)
- MAS (1)
- METTL8 (1)
- Mandibular continuity defects (1)
- Marcus inverted region (1)
- Marrow stromal cells (1)
- Merocyanine (1)
- Mesenchymal transition (1)
- Microenvironment (1)
- Migratory aptitudes in carbocations (1)
- Mitochondrial Matrix Protein (1)
- Mizellen (1)
- Modified Nucleotides in tRNAs (1)
- Molecular mechanism (1)
- Molecular-dynamics (1)
- Molecules (1)
- Molnupiravir (1)
- Molnupiravir-Induced RNA Mutagenesis Mechanism (1)
- Multibranched structures (1)
- N-oleoyl serinol (1)
- NDI-H (1)
- NIR OLED (1)
- NMR spectroscopy (1)
- Nahordnung (1)
- Naphthylisoindolinone alkaloids (1)
- Neighbouring group participation (1)
- Neisseria (1)
- Nonbonded Interactions (1)
- Norcaranes (1)
- Norpinanes (1)
- Nucleic Acids (1)
- Nucleobase Analogue (1)
- OEG chains (1)
- Octavalen (1)
- Oligofructoside (1)
- One-photon (1)
- Optical Spectroscopy (1)
- Optical properties (1)
- Optical spectroscopy (1)
- Oral squamous cell carcinoma (1)
- Organelles (1)
- Organobor (1)
- PBI cyclophane (1)
- PI stacking (1)
- Pathway (1)
- Perovskite (1)
- Phaeophyceae (1)
- Photochemistry (1)
- Photoelektron (1)
- Photoresponsives Verhalten (1)
- Polymer-drug interaction (1)
- Polymere (1)
- Polymers (1)
- Potential-energy curves (1)
- QM/MM (1)
- RNA Enzymes (1)
- RNA Labelling (1)
- RNA Methyltransferase (1)
- RNA Modification (1)
- RNA aptamers (1)
- RNA labeling (1)
- RNA ligation (1)
- RNA splicing (1)
- RNA-Aptamere (1)
- RNA-Dependent RNA Polymerase (1)
- RU-(II) complexes (1)
- Radical-ion pair (1)
- Rearrangement of carbocations (1)
- Remdesivir (1)
- Ribozyme (1)
- Ru(II)–Fe(II)–Ru(II) complex (1)
- SARS-CoV-2 polymerase (1)
- SARS-CoV2 Replication Impairment (1)
- SacB (1)
- Scleractinia (1)
- Screening (1)
- Selbstassemblierung (1)
- Simulations (1)
- Sinus floor augmentation (1)
- Site-Specific RNA Cleavage (1)
- Site-specific RNA labelling (1)
- Solution-state NMR (1)
- Spin density (1)
- Spirotetracyclo[4.1.0.0<sup>2 (1)
- Squamous-cell carcinoma (1)
- Sracking (1)
- Staphylococcus aureus (1)
- State (1)
- Stereochemistry (1)
- Stokes-Verschiebung (1)
- Stokes-shifted fluorescence emission (1)
- Streptomyces axinellae (1)
- Structural Biology (1)
- Structure elucidation (1)
- Struktursonden (1)
- Stylissa carteri (1)
- Suc1 (1)
- Supramolecular Element (1)
- Supramolekulare Polymere (1)
- Suzuki coupling (1)
- Synthetic Functional RNAs (1)
- Systems (1)
- TERRA RNA (1)
- Tetrakis(arylmethylene)ethane diradical (1)
- Thalassodendron ciliatum (1)
- Tricyclo[3.3.1.0 2 (1)
- Tricyclo[4.1.0.0<sup>2.7</sup>]heptanes (1)
- Tumorigenicity (1)
- Urazoles (1)
- Vibronic contributions (1)
- X-ray Crystallography (1)
- X-ray crystallography (1)
- X-ray diffraction (1)
- XNA (1)
- XRPD (1)
- Zirkulardichroismus (1)
- [1 (1)
- [2 + 2]- and [4 + 2]- (1)
- [n]helicenes (1)
- \(\alpha\)-phase (1)
- \(\beta\)-phase (1)
- \(^{1}\)H-\(^{13}\)C HETCOR (1)
- abietane (1)
- activating transcription factor 4 (ATF4) (1)
- adsorption (1)
- aelf-assembly (1)
- alkaloids (1)
- alpha (1)
- amphiphilic dyes (1)
- amplification (1)
- ancistrocladinium A (1)
- annihilation (1)
- anti-cancer-agent (1)
- anti-depressant drug (1)
- anti-trypanosomal (1)
- antibacterial activity (1)
- antidepressants (1)
- antimicrobials (1)
- aqua material (1)
- aqueous medium (1)
- arene-fluoroarene (1)
- arenes (1)
- artificial base pair (1)
- association (1)
- ataxia teleagiectasia mutated (ATM) (1)
- azaborole (1)
- azaphilone (1)
- azido-ceramides (1)
- bacterial infection (1)
- bartalinia robillardoides (1)
- bicyclic (1)
- biflavanoids (1)
- bile salt (1)
- bioactive compound (1)
- bioactivities (1)
- biocompatibility (1)
- biological techniques (1)
- biomass (1)
- bioorthogonal SAM analogue ProSeDMA (1)
- bioorthogonal metabolic glycoengineering; click chemistry; sialic acid (1)
- biophysical investigation (1)
- biosynthesis (1)
- bis-terpyridyl ligands (1)
- boric acid (1)
- boron (1)
- boronateesters (1)
- borylation (1)
- brown seaweeds (1)
- bulk-heterojunction solar cells (1)
- carbon (1)
- carrier transport (1)
- cascade reactions (1)
- catalyst (1)
- catalyst synthesis (1)
- catalysts (1)
- catalytic (1)
- catalytic activity (1)
- catalytic mechanisms (1)
- cell membrane model (1)
- cellular stress response (1)
- ceramidase (1)
- ceramide analogs (1)
- cerebroside (1)
- ceriops decandra (1)
- charge transport (1)
- charge transport; hydrogen bonding; oligothiophene; organogel; self-assembly (1)
- chiral resolution (1)
- circular polarized luminescence (1)
- circularly polarized luminescence (1)
- classical and nonclassical (1)
- co-aggregation (1)
- cocrystallization (1)
- colloid (1)
- columnar phases (1)
- complexity (1)
- configurational stability (1)
- conformation (1)
- conjugated molecule (1)
- cooperative self-assembly (1)
- coordination chemistry (1)
- coordination oligomer (1)
- coordination oligomers (1)
- covalent organic framework (1)
- covalent organic frameworks (1)
- cristal engeneering (1)
- crystalline (1)
- crystals (1)
- curcumin (1)
- curvature (1)
- curved π-systems (1)
- cyclic / 1-0xa-2 (1)
- cyclic perylene bisimide (1)
- cyclodehydrogenation (1)
- cylindrical micelles (1)
- cysteine protease (1)
- cytoplasm (1)
- d]cycloheptene (1)
- decandrinin (1)
- deoxyribozymes (1)
- deracemization (1)
- di-\(\pi\)-methane rearrangement (1)
- dibenzosemibullvalenes (1)
- differential scanning calorimetry (1)
- diffusion (1)
- diketopyrrolopyrroles (1)
- dimerization (1)
- dimers (1)
- dinuclear (1)
- dipole-dipole interaction (1)
- discotic liquid crystals (1)
- discovery (1)
- dissolution rates (1)
- disulfide bonds (1)
- docking (1)
- docking studies (1)
- donor-acceptor dyad (1)
- donor-acceptor interactions (1)
- donor–acceptor (1)
- donor–acceptor dyads (1)
- drug delivery (1)
- drugs (1)
- duplex structure (1)
- dye assembly (1)
- dye chemistry (1)
- electronic collective variables (1)
- electronic structure (1)
- electronic wavefunction (1)
- emission (1)
- enantiomerization (1)
- enantiomers (1)
- enzyme (1)
- enzyme purification (1)
- enzyme structure (1)
- enzymes (1)
- epitranscriptomics (1)
- ergosterol derivative (1)
- ethenoanthracenes (1)
- excimer (1)
- excimer formation (1)
- extractives (1)
- ferroelectrics (1)
- films (1)
- flavenoids (1)
- flavonoids (1)
- flourescence quantum yield (1)
- fluerescence (1)
- fluorenscence (1)
- fluorescence resonance energy transfer (1)
- fluorescence spectroscopy (1)
- fluorescent (1)
- fluorescent probes (1)
- fluorogen-activating RNA aptamer (FLAP) (1)
- fluoxetine (1)
- flux (1)
- folded macrocyles (1)
- folding (1)
- folding landscapes (1)
- functionalization (1)
- generation and rearrangement (1)
- glycocalyx (1)
- glycosphingolipids (1)
- growth (1)
- guttiferae (1)
- hMSC-TERT (1)
- halichondria panicea (1)
- heavy metals (1)
- helicene (1)
- heterocycles (1)
- hexakisadducts (1)
- high-temperature NMR (1)
- highly substituted (1)
- homochiral dimer (1)
- host-guest systems (1)
- hybrid materials (1)
- hydrazone (1)
- hydrocarbons (1)
- hydrolysis (1)
- hydroxylation (1)
- imaging (1)
- imidization (1)
- in vitro Selection (1)
- induced phase transition (1)
- inflammation (1)
- intersystem crossing (1)
- intrinsic free space (1)
- invasion (1)
- inflammatory response (1)
- ion pairing (1)
- iron oxide nanoparticles (1)
- isomorphic nucleobase analog (1)
- key structure - fluorescence activation relationships (SFARs) (1)
- kinetics of thermolysis (1)
- lH-Cyclopropa[a]naphthalenes (1)
- large stokes shift (1)
- laser (1)
- lectin (1)
- ligand binding (1)
- ligands (1)
- liposome (1)
- liquid crystal alignment (1)
- livingstonei (1)
- macrocycle (1)
- major depression (1)
- marine bacteria (1)
- marine fungi (1)
- marine macroalgae (1)
- marine natural products (1)
- marine sponge (1)
- materials (1)
- materials design (1)
- measles (1)
- mechanism (1)
- merocyanine (1)
- merocyanine dyes/pigments (1)
- mesogens (1)
- metabolic analysis (1)
- metabolic glycoengineering (1)
- metadynamics (1)
- metal complexenes (1)
- metal-to-ligand charge transfer (MLCT) (1)
- metallomacrocycles (1)
- methyl viologen (1)
- methyltransferase (1)
- micelles (1)
- microbiology (1)
- microbiology techniques (1)
- microscopy (1)
- migration (1)
- minimal inhibitory concentration (1)
- mobility (1)
- modified monosaccharides (1)
- molecular (1)
- molecular capsules (1)
- molecular dynamics (1)
- molecules (1)
- mtrogen extruston (1)
- multiflora (1)
- multimetallic complexes (1)
- multiple myeloma (1)
- nanoparticles (1)
- nanorods and nanosheets (1)
- nanoscale imaging (1)
- nanosegregation (1)
- nanotube (1)
- naphthalene diimide (1)
- naphthylisoquinoline alkaloid (1)
- naphthylisoquinoline alkaloids (1)
- narrow bandwidth (1)
- natural products (1)
- near infrared emitter (1)
- near-infrared sensitivity (1)
- non-fullerene acceptors (1)
- noncovalent interactions (1)
- nonfullerene acceptors (1)
- nucleation elongation (1)
- nucleation-elongation (1)
- nucleation-elongation model (1)
- nucleoside modification recognition (1)
- obstructive pulmonary disease (1)
- oligothiophene (1)
- oligothiophenes (1)
- optical materials (1)
- optics (1)
- organic semiconductors (1)
- organic compounds (1)
- organic light emitting diodes (1)
- organization (1)
- orylation (1)
- oxidation (1)
- pancreatic cancer (1)
- parallel polar dimers (1)
- pentaketide (1)
- peptide backbone (1)
- perylene bisimide dyes (1)
- perylene bisimide hydrogels (1)
- perylene bismide dye (1)
- perylene imide (1)
- perylenebisimide (1)
- perylenebisimide dyes (1)
- phenazine (1)
- phenyl-substituted (1)
- phenylboronate (1)
- phosphodiesterase-4 inhibitor (1)
- photochemical (1)
- photoconductive interlayer (1)
- photoluminescence (1)
- photosenitizers (1)
- photosensitization (1)
- phthalocyanines (1)
- platinum complexes (1)
- pol(2-oxazoline) (1)
- polarizing optical microscopy (1)
- poly(2-oxazine) (1)
- polycycles (1)
- polycyclic (1)
- polycyclic aromatic hydrocarbon (1)
- polymer drug interaction (1)
- polymorphism (1)
- polyoxazolines (1)
- polypyridyl complexes (1)
- porous materials (1)
- porousmaterials (1)
- porphyrins (1)
- probes (1)
- protease inhibition (1)
- proteasome inhibitor resistance (1)
- proteasome subunit beta type-5 (PSMB5) (1)
- push–pull thienylthiazole (1)
- pyrene (1)
- quantum chemical analysis (1)
- quantum optics (1)
- racemization (1)
- radical (1)
- radical anion (1)
- reabsorption (1)
- real-time NMR spectroscopy (1)
- rearrangement (1)
- recombinant proteins (1)
- redox (1)
- regulatory T cells (1)
- regulatory T cells (Treg) (1)
- renew-able fuels (1)
- rhizophoraceae (1)
- ribozymes (1)
- rigidification (1)
- rofumilast (1)
- room-temperature phosphorescence (RTP) (1)
- rotational diffusion (1)
- ruthenium catalysts (1)
- sSupramolecular interaction (1)
- seagrass (1)
- self-sorting (1)
- separation techniques (1)
- shape-amphiphiles (1)
- short-range order (1)
- sialic acids (1)
- simulated intestinal fluid (1)
- single crystal structure (1)
- site-specific RNA labeling (1)
- six-membered (1)
- social self‐sorting (1)
- solar cells (1)
- solar fuels (1)
- solid-state NMR (1)
- solid-state NMR spectroscopy (1)
- solid‐state emission (1)
- solubility (1)
- solvatochromism (1)
- solvolysis of (1)
- spectroscopic analysis (1)
- sphingolipid expansion microscopy (1)
- sphingomyelinase (1)
- sphingosine (1)
- sphingosine 1-phosphate (1)
- sphingosine kinases (1)
- stability (1)
- star-shaped compounds (1)
- starazine (1)
- starphene analogue (1)
- stereospecific sythesis (1)
- sterubin (1)
- stokes shift (1)
- structural biology (1)
- structural changes (1)
- structural dynamics (1)
- structure probes (1)
- structure probing (1)
- structure–function relation (1)
- structure–property relation (1)
- subphthalocyanine (1)
- substituted (1)
- substituted 2-oxo- dimethyl esters (1)
- superparamagnetism (1)
- superstructure (1)
- supramolecular assembly (1)
- supramolecular folding (1)
- supramolecular materials (1)
- supramolecular polymerization (1)
- supramolecular polymers (1)
- survival (1)
- sustainable energy source (1)
- swallow-tail (1)
- systems (1)
- template catalysis (1)
- tenofovir (1)
- tethya aurantium (1)
- tetracoordinated boron (1)
- tetromycin (1)
- theranostics (1)
- thin-film transistors (1)
- time-resolved impulsive stimulated raman spectroscopy (1)
- tissue engineering (1)
- transient absorption (1)
- triarylamine (1)
- triarylborane (1)
- trinuclear (1)
- triplet (1)
- triplet sensitization (1)
- two-dimensional nanostructures (1)
- umbrella-shaped mesogens (1)
- upconversion (1)
- upramolecular polymerization process (1)
- vacuum processable (1)
- vibrational coherence (1)
- viral epidemiology (1)
- viral infection (1)
- water oxidation catalysis (1)
- y-Oxoketenes (1)
- zooxanthellae (1)
- ß-Lactones (1)
- ß-unsaturated (1)
- β-Lactones (1)
- δ-Lactones (1)
- δ-chloro- (1)
- π-Konjugierte Systeme (1)
- π-conjugated systems (1)
- π-extension (1)
- π-π-interactions (1)
- π–π Stacking (1)
Institute
- Institut für Organische Chemie (310) (remove)
Sonstige beteiligte Institutionen
- Agricultural Center, BASF SE, 67117 Limburgerhof, Germany (1)
- Cluster of Excellence "Multiscale Bioimaging: from Molecular Machines to Networks of Excitable Cells, Göttingen (1)
- Department of Cellular Biochemistry, University Medical Center Göttingen (1)
- Department of Cellular Biochemistry, University Medical Centre Göttingen (1)
- Department of Molecular Biology, University Medical Centre Göttingen (1)
- Georg August University School of Science (1)
- Göttingen Center for Molecular Biosciences, University of Göttingen (1)
- Helmholtz Institute for RNA-based Infection Biology (HIRI), Josef-Schneider-Straße 2/D15, DE-97080 Wuerzburg, Germany (1)
- Institut für Molekulare Infektionsbiologie (MIB) der Universität Würzburg (1)
- Institute of Cancer Research (ICR) London (1)
EU-Project number / Contract (GA) number
- 682586 (15)
- 787937 (12)
- 693023 (2)
- 242175-VascuBone (1)
- 242175‐VascuBone (1)
- 643238 (1)
- 654000 (1)
- 715923 (1)
- LaserLab Europe (LLC001917) (1)
Natural light harvesting as well as optoelectronic and photovoltaic devices depend on efficient transport of energy following photoexcitation. Using common spectroscopic methods, however, it is challenging to discriminate one-exciton dynamics from multi-exciton interactions that arise when more than one excitation is present in the system. Here we introduce a coherent two-dimensional spectroscopic method that provides a signal only in case that the presence of one exciton influences the behavior of another one. Exemplarily, we monitor exciton diffusion by annihilation in a perylene bisimide-based J-aggregate. We determine quantitatively the exciton diffusion constant from exciton–exciton-interaction 2D spectra and reconstruct the annihilation-free dynamics for large pump powers. The latter enables for ultrafast spectroscopy at much higher intensities than conventionally possible and thus improves signal-to-noise ratios for multichromophore systems; the former recovers spatio–temporal dynamics for a broad range of phenomena in which exciton interactions are present.
AbstractWater oxidation catalysis is a key step for sustainable fuel production by water splitting into hydrogen and oxygen. The synthesis of a novel coordination oligomer based on four Ru(bda) (bda = 2,2′‐bipyridine‐6,6′‐dicarboxylate) centers, three 4,4′‐bipyridine (4,4′‐bpy) linkers, and two 4‐picoline (4‐pic) end caps is reported. The monodispersity of this tetranuclear compound is characterized by NMR techniques. Heterogeneous electrochemical water oxidation after immobilization on multi‐walled carbon nanotubes (MWCNTs) shows catalytic performance unprecedented for this compound class, with a turnover frequency (TOF) of 133 s\(^{−1}\) and a turnover number (TON) of 4.89 × 10\(^6\), at a current density of 43.8 mA cm\(^{−2}\) and a potential of 1.45 V versus normal hydrogen electrode (NHE).
The N,C-coupled naphthylisoquinoline alkaloid ancistrocladinium A belongs to a novel class of natural products with potent antiprotozoal activity. Its effects on tumor cells, however, have not yet been explored. We demonstrate the antitumor activity of ancistrocladinium A in multiple myeloma (MM), a yet incurable blood cancer that represents a model disease for adaptation to proteotoxic stress. Viability assays showed a potent apoptosis-inducing effect of ancistrocladinium A in MM cell lines, including those with proteasome inhibitor (PI) resistance, and in primary MM cells, but not in non-malignant blood cells. Concomitant treatment with the PI carfilzomib or the histone deacetylase inhibitor panobinostat strongly enhanced the ancistrocladinium A-induced apoptosis. Mass spectrometry with biotinylated ancistrocladinium A revealed significant enrichment of RNA-splicing-associated proteins. Affected RNA-splicing-associated pathways included genes involved in proteotoxic stress response, such as PSMB5-associated genes and the heat shock proteins HSP90 and HSP70. Furthermore, we found strong induction of ATF4 and the ATM/H2AX pathway, both of which are critically involved in the integrated cellular response following proteotoxic and oxidative stress. Taken together, our data indicate that ancistrocladinium A targets cellular stress regulation in MM and improves the therapeutic response to PIs or overcomes PI resistance, and thus may represent a promising potential therapeutic agent.
The reversible condensation of catechols and boronic acids to boronate esters is a paradigm reaction in dynamic covalent chemistry. However, facile backward hydrolysis is detrimental for stability and has so far prevented applications for boronate-based materials. Here, we introduce cubic boronate ester cages 6 derived from hexahydroxy tribenzotriquinacenes and phenylene diboronic acids with ortho-t-butyl substituents. Due to steric shielding, dynamic exchange at the Lewis acidic boron sites is feasible only under acid or base catalysis but fully prevented at neutral conditions. For the first time, boronate ester cages 6 tolerate substantial amounts of water or alcohols both in solution and solid state. The unprecedented applicability of these materials under ambient and aqueous conditions is showcased by efficient encapsulation and on-demand release of β-carotene dyes and heterogeneous water oxidation catalysis after the encapsulation of ruthenium catalysts.
Conspectus
Nature has established a sustainable way to maintain aerobic life on earth by inventing one of the most sophisticated biological processes, namely, natural photosynthesis, which delivers us with organic matter and molecular oxygen derived from the two abundant resources sunlight and water. The thermodynamically demanding photosynthetic water splitting is catalyzed by the oxygen-evolving complex in photosystem II (OEC-PSII), which comprises a distorted tetramanganese–calcium cluster (CaMn\(_4\)O\(_5\)) as catalytic core. As an ubiquitous concept for fine-tuning and regulating the reactivity of the active site of metalloenzymes, the surrounding protein domain creates a sophisticated environment that promotes substrate preorganization through secondary, noncovalent interactions such as hydrogen bonding or electrostatic interactions. Based on the high-resolution X-ray structure of PSII, several water channels were identified near the active site, which are filled with extensive hydrogen-bonding networks of preorganized water molecules, connecting the OEC with the protein surface. As an integral part of the outer coordination sphere of natural metalloenzymes, these channels control the substrate and product delivery, carefully regulate the proton flow by promoting pivotal proton-coupled electron transfer processes, and simultaneously stabilize short-lived oxidized intermediates, thus highlighting the importance of an ordered water network for the remarkable efficiency of the natural OEC.
Transferring this concept from nature to the engineering of artificial metal catalysts for fuel production has fostered the fascinating field of metallosupramolecular chemistry by generating defined cavities that conceptually mimic enzymatic pockets. However, the application of supramolecular approaches to generate artificial water oxidation catalysts remained scarce prior to our initial reports, since such molecular design strategies for efficient activation of substrate water molecules in confined nanoenvironments were lacking. In this Account, we describe our research efforts on combining the state-of-the art Ru(bda) catalytic framework with structurally programmed ditopic ligands to guide the water oxidation process in defined metallosupramolecular assemblies in spatial proximity. We will elucidate the governing factors that control the quality of hydrogen-bonding water networks in multinuclear cavities of varying sizes and geometries to obtain high-performance, state-of-the-art water oxidation catalysts. Pushing the boundaries of artificial catalyst design, embedding a single catalytic Ru center into a well-defined molecular pocket enabled sophisticated water preorganization in front of the active site through an encoded basic recognition site, resulting in high catalytic rates comparable to those of the natural counterpart OEC-PSII.
To fully explore their potential for solar fuel devices, the suitability of our metallosupramolecular assemblies was demonstrated under (electro)chemical and photocatalytic water oxidation conditions. In addition, testing the limits of structural diversity allowed the fabrication of self-assembled linear coordination oligomers as novel photocatalytic materials and long-range ordered covalent organic framework (COF) materials as recyclable and long-term stable solid-state materials for future applications.
The discrimination of enantiomers by natural receptors is a well-established phenomenon. In contrast the number of synthetic receptors with the capability for enantioselective molecular recognition of chiral substrates is scarce and for chiral cyclophanes indicative for a preferential binding of homochiral guests. Here we introduce a cyclophane composed of two homochiral core-twisted perylene bisimide (PBI) units connected by p-xylylene spacers and demonstrate its preference for the complexation of [5]helicene of opposite helicity compared to the PBI units of the host. The pronounced enantio-differentiation of this molecular receptor for heterochiral guests can be utilized for the enrichment of the P-PBI-M-helicene-P-PBI epimeric bimolecular complex. Our experimental results are supported by DFT calculations, which reveal that the sterically demanding bay substituents attached to the PBI chromophores disturb the helical shape match of the perylene core and homochiral substrates and thereby enforce the formation of syndiotactic host-guest complex structures. Hence, the most efficient substrate binding is observed for those aromatic guests, e. g. perylene, [4]helicene, phenanthrene and biphenyl, that can easily adapt in non-planar axially chiral conformations due to their inherent conformational flexibility. In all cases the induced chirality for the guest is opposed to those of the embedding PBI units, leading to heterochiral host-guest structures.
Recently, we have shown that C6-ceramides efficiently suppress viral replication by trapping the virus in lysosomes. Here, we use antiviral assays to evaluate a synthetic ceramide derivative α-NH2-ω-N3-C6-ceramide (AKS461) and to confirm the biological activity of C6-ceramides inhibiting SARS-CoV-2. Click-labeling with a fluorophore demonstrated that AKS461 accumulates in lysosomes. Previously, it has been shown that suppression of SARS-CoV-2 replication can be cell-type specific. Thus, AKS461 inhibited SARS-CoV-2 replication in Huh-7, Vero, and Calu-3 cells up to 2.5 orders of magnitude. The results were confirmed by CoronaFISH, indicating that AKS461 acts comparable to the unmodified C6-ceramide. Thus, AKS461 serves as a tool to study ceramide-associated cellular and viral pathways, such as SARS-CoV-2 infections, and it helped to identify lysosomes as the central organelle of C6-ceramides to inhibit viral replication.
Post-transcriptional RNA modification methods are in high demand for site-specific RNA labelling and analysis of RNA functions. In vitro-selected ribozymes are attractive tools for RNA research and have the potential to overcome some of the limitations of chemoenzymatic approaches with repurposed methyltransferases. Here we report an alkyltransferase ribozyme that uses a synthetic, stabilized S-adenosylmethionine (SAM) analogue and catalyses the transfer of a propargyl group to a specific adenosine in the target RNA. Almost quantitative conversion was achieved within 1 h under a wide range of reaction conditions in vitro, including physiological magnesium ion concentrations. A genetically encoded version of the SAM analogue-utilizing ribozyme (SAMURI) was expressed in HEK293T cells, and intracellular propargylation of the target adenosine was confirmed by specific fluorescent labelling. SAMURI is a general tool for the site-specific installation of the smallest tag for azide-alkyne click chemistry, which can be further functionalized with fluorophores, affinity tags or other functional probes.
Site-specific introduction of biorthogonal handles into RNAs is in high demand for decorating RNAs with fluorophores, affinity labels or other modifications. Aldehydes represent attractive functional groups for post-synthetic bioconjugation reactions. Here, we report a ribozyme-based method for the synthesis of aldehyde-functionalized RNA by directly converting a purine nucleobase. Using the methyltransferase ribozyme MTR1 as an alkyltransferase, the reaction is initiated by site-specific N1 benzylation of purine, followed by nucleophilic ring opening and spontaneous hydrolysis under mild conditions to yield a 5-amino-4-formylimidazole residue in good yields. The modified nucleotide is accessible to aldehyde-reactive probes, as demonstrated by the conjugation of biotin or fluorescent dyes to short synthetic RNAs and tRNA transcripts. Upon fluorogenic condensation with a 2,3,3-trimethylindole, a novel hemicyanine chromophore was generated directly on the RNA. This work expands the MTR1 ribozyme’s area of application from a methyltransferase to a tool for site-specific late-stage functionalization of RNA.
The solvatochromic behavior of two donor-π bridge-acceptor (D-π-A) compounds based on the 2-(3-boryl-2-thienyl)thiazole π-linker and indandione acceptor moiety are investigated. DFT/TD-DFT calculations were performed in combination with steady-state absorption and emission measurements, along with electrochemical studies, to elucidate the effect of two different strongly electron-donating hydrazonyl units on the solvatochromic and fluorescence behavior of these compounds. The Lippert–Mataga equation was used to estimate the change in dipole moments (Δµ) between ground and excited states based on the measured spectroscopic properties in solvents of varying polarity with the data being supported by theoretical studies. The two asymmetrical D-π-A molecules feature strong solvatochromic shifts in fluorescence of up to ~4300 cm\(^{−1}\) and a concomitant change of the emission color from yellow to red. These changes were accompanied by an increase in Stokes shift to reach values as large as ~5700–5800 cm\(^{−1}\). Quantum yields of ca. 0.75 could be observed for the N,N-dimethylhydrazonyl derivative in nonpolar solvents, which gradually decreased along with increasing solvent polarity, as opposed to the consistently reduced values obtained for the N,N-diphenylhydrazonyl derivative of up to ca. 0.20 in nonpolar solvents. These two push–pull molecules are contrasted with a structurally similar acceptor-π bridge-acceptor (A-π-A) compound.