Refine
Year of publication
Document Type
- Conference Proceeding (108) (remove)
Language
- English (108) (remove)
Keywords
- Schwertkärpfling (7)
- Immunbiologie (5)
- Psychologie (5)
- PET (4)
- Toxikologie (4)
- Virtuelle Realität (4)
- positron emission tomography (4)
- Begabung (3)
- HIV (3)
- Interkulturelles Lernen (3)
Institute
- Theodor-Boveri-Institut für Biowissenschaften (24)
- Institut für Psychologie (bis Sept. 2007) (13)
- Klinik und Poliklinik für Allgemein-, Viszeral-, Gefäß- und Kinderchirurgie (Chirurgische Klinik I) (11)
- Institut für Informatik (9)
- Institut für Mineralogie und Kristallstrukturlehre (8)
- Klinik und Poliklinik für Nuklearmedizin (8)
- Institut für Pharmakologie und Toxikologie (6)
- Institut Mensch - Computer - Medien (4)
- Institut für Psychologie (4)
- Physikalisches Institut (4)
Schriftenreihe
Sonstige beteiligte Institutionen
- Johns Hopkins School of Medicine, Baltimore, MD, U.S. (4)
- Cologne Game Lab (3)
- Johns Hopkins School of Medicine (3)
- Open University of the Netherlands (2)
- Birmingham City University (1)
- Brown University (1)
- DATE Lab, KITE Research Insititute, University Health Network, Toronto, Canada (1)
- Hospital Augsburg, Augsburg, Germany (1)
- Johns Hopkins University School of Medicine, Baltimore, MD, U.S. (1)
- Social and Technological Systems (SaTS) lab, School of Art, Media, Performance and Design, York University, Toronto, Canada (1)
EU-Project number / Contract (GA) number
- 701983 (8)
The capacity of Xiphophorus to develop neoplasia can be formally assigned to a "tumor gene" (Tu), which appears to be a normal part of the genome of all individuals. The wild fish have evolved population-specific and cell type-specific systems of regulatory genes (R) for Tu that protect the fish from neoplasia. Hybridization of members of different wild populations in the laborstory followed by treatment of the hybrids with carcinogens led to disintegration of the R systems permitting excessive expression of Tu and thus resulting in neoplasia. Certain hybrids developed neoplasia even spontaneously. Observations on the genuine phenotypic effect of the derepressed Tu in the early embryo indicated an essential normal function of this oncogene in cell differentiation, proliferation and cell-cell communication. Tu appeared to be indispensable in the genome but may also be present in accessory copics. Recently, c-src, the cellular homolog of the Rous sarcoma virus oncogene v-src, was detected in Xiphophorus. The protein product of c-src, pp60c-src, was identified and then examined by its associated kinase activity. This pp60c-src was found in all individuals tested, but, depending on the genotype, its kinase activity was different. The genetic characters of c-src, such as linkage relations, dosage relations, expression, etc., correspond to those of Tu. From a systematic study which showed that pp60c-src was present in all metazoa tested ranging from mammals down to sponges, we concluded that c-src has evolved with the multicellular organization of animals. Neoplasia of animals and humans is a characteristic closely related to this evolution. Our data showed that small aquariurn fish, besides being used successfully because they are time-, space-, and money-saving systems for carcinogenicity testing, are also highly suitable for basic studies on neoplasia at the populational, morphological, developmental, cell biological, and molecular levels.
In the present work we report the results of magneto-transport measurements on some Hg-based li-VI semiconductor epitaxiallayers grown by molecular beam epitaxy. The transport measurement were carried out at temperatures in the range 0.4 - 4.2 K in magnetic fields up to 10.0 T. Further, we point out the necessity of using multicarrier models for data interpretation and show finally some Shubnikov-de-Haas results on sampies with high mobility carners.
Immersive virtual environments provide users with the opportunity to escape from the real world, but scripted dialogues can disrupt the presence within the world the user is trying to escape within. Both Non-Playable Character (NPC) to Player and NPC to NPC dialogue can be non-natural and the reliance on responding with pre-defined dialogue does not always meet the players emotional expectations or provide responses appropriate to the given context or world states. This paper investigates the application of Artificial Intelligence (AI) and Natural Language Processing to generate dynamic human-like responses within a themed virtual world. Each thematic has been analysed against humangenerated responses for the same seed and demonstrates invariance of rating across a range of model sizes, but shows an effect of theme and the size of the corpus used for fine-tuning the context for the game world.