Refine
Has Fulltext
- yes (323)
Is part of the Bibliography
- yes (323)
Year of publication
Document Type
- Journal article (191)
- Doctoral Thesis (131)
- Review (1)
Keywords
- NFATc1 (15)
- apoptosis (14)
- NFAT (10)
- immunohistochemistry (10)
- lymphoma (10)
- Transkriptionsfaktor (9)
- Apoptose (8)
- B-Zell-Lymphom (8)
- CXCR4 (8)
- DLBCL (8)
- Non-Hodgkin-Lymphom (8)
- T-Lymphozyt (7)
- cancer (7)
- prognosis (7)
- Apoptosis (6)
- Lymphom (6)
- T cells (6)
- breast cancer (6)
- gene expression (6)
- glioblastoma (6)
- multiple myeloma (6)
- thymoma (6)
- thymus (6)
- B cells (5)
- Lymphome (5)
- Proliferation (5)
- astrocytoma (5)
- follicular lymphoma (5)
- glioblastoma multiforme (5)
- recurrence (5)
- therapy (5)
- Amplifikation (4)
- Autoaggressionskrankheit (4)
- EGFR (4)
- FISH (4)
- Fluoreszenz-in-situ-Hybridisierung (4)
- Follikuläres Lymphom (4)
- Immunhistochemie (4)
- Immuntherapie (4)
- Krebs <Medizin> (4)
- Microarray (4)
- NF-AT (4)
- Prognose (4)
- Thymom (4)
- Thymus (4)
- amplification (4)
- brain (4)
- chemokine receptor (4)
- expression (4)
- forensic neuropathology (4)
- gene regulation (4)
- mRNA (4)
- machine learning (4)
- metastasis (4)
- relapse (4)
- thymic carcinoma (4)
- transcription factors (4)
- B-Lymphozyten (3)
- Brustkrebs (3)
- CGH (3)
- EBV (3)
- Ependymom (3)
- Genexpression (3)
- Histopathologie (3)
- Hodgkin lymphoma (3)
- Immunglobulin M (3)
- Keimzentrum (3)
- Lymphknoten (3)
- Lymphoma (3)
- Lymphozyten (3)
- MALT1 (3)
- MYC (3)
- Malignes Lymphom (3)
- Medizin (3)
- Myasthenia gravis (3)
- NRF2 (3)
- PET/CT (3)
- Pathologie (3)
- T-cell lymphoma (3)
- adrenocortical carcinoma (3)
- biomarker (3)
- brain tumor (3)
- cerebrospinal fluid (3)
- comparative genomic hybridization (3)
- diffuse large B-cell lymphoma (3)
- flow cytometry (3)
- forensic neurotraumatology (3)
- germinal center (3)
- glioma (3)
- loss of heterozygosity (3)
- melanoma (3)
- monoclonal antibody (3)
- myasthenia gravis (3)
- neuronal differentiation (3)
- poor prognosis (3)
- positron emission tomography (3)
- protein (3)
- surgical oncology (3)
- AICD (2)
- ATF4 (2)
- Angeborene Immunität (2)
- Antigen (2)
- Antikörper (2)
- B-cell lymphoma (2)
- BCL6 (2)
- CD30 (2)
- CRISPR/Cas9 (2)
- CXCR2 (2)
- Colonkrebs (2)
- Cushing’s syndrome (2)
- Deletion (2)
- Differenzierung (2)
- E-cadherin (2)
- EMT (2)
- Epidermaler Wachstumsfaktor-Rezeptor (2)
- Epstein-Barr-Virus (2)
- Expression (2)
- FFPE (2)
- FGFR (2)
- Glioblastoma (2)
- Graft-versus-leukemia (2)
- HNSCC (2)
- Hodgkin (2)
- Humorale Immunität (2)
- Immuncytochemie (2)
- Immunglobuline (2)
- Immunologie (2)
- Immunotherapy (2)
- Immunsystem (2)
- KEAP1 (2)
- Krebs (2)
- LOH (2)
- Lymphogranulomatose (2)
- MALT (2)
- MALT-Lymphom (2)
- MALT-lymphoma (2)
- MPS1 (2)
- Magenkarzinom (2)
- Magenkrebs (2)
- Mammakarzinom (2)
- Mantelzell-Lymphom (2)
- Mantle cell lymphoma (2)
- Maus (2)
- Methylation (2)
- Methylierung (2)
- Mikrosatellitenanalyse (2)
- Mikrosatelliteninstabilität (2)
- Molekularbiologie (2)
- Monoklonaler Antikörper (2)
- Multiple Myeloma (2)
- NAFLD (2)
- NASH (2)
- NHL (2)
- NSCLC (2)
- Nekrose (2)
- Neuroinflammation (2)
- Nfatc1 (2)
- Onkogen (2)
- PD-L1 (2)
- PET (2)
- PTCL (2)
- Plattenepithelcarcinom (2)
- Protein p53 (2)
- Rhabdomyosarcoma (2)
- SC-1 (2)
- Signaltransduktion (2)
- Speicheldrüse (2)
- T-Lymphozyten (2)
- T-Zell-Lymphome (2)
- T-Zellen (2)
- T-cell differentiation (2)
- TAF15 (2)
- TTK (2)
- Thymuskarzinome (2)
- Transkriptionsfaktoren (2)
- Tumor (2)
- Tumorimmunologie (2)
- Tumorsuppressorgen (2)
- USP28 (2)
- VEGF (2)
- alloreactive T cells (2)
- amplicon sequencing (2)
- angiogenesis (2)
- animal model (2)
- antigen (2)
- autoimmune disease (2)
- cancer stem cells (2)
- cancers and neoplasms (2)
- carcinomas (2)
- case report (2)
- cell staining (2)
- cell-cycle arrest (2)
- chemokine (2)
- chromosomal aberration (2)
- classification (2)
- cytotoxic T cells (2)
- development (2)
- discriminant analysis (2)
- endothelial cells (2)
- enzyme-linked immunoassays (2)
- ependymoma (2)
- extranodal (2)
- gastric carcinoma (2)
- gene (2)
- genetic aberrations (2)
- genetische Aberrationen (2)
- grade 3B (2)
- humoral immunity (2)
- imaging (2)
- immune response (2)
- immunohistochemistry techniques (2)
- immunotherapy (2)
- in vivo imaging (2)
- inflammation (2)
- innate immunity (2)
- keratinocytes (2)
- kidneys (2)
- low-grade glioma (2)
- lung cancer (2)
- malignant tumors (2)
- mantle cell lymphoma (2)
- messenger RNA (2)
- miRNA (2)
- mice (2)
- microenvironment (2)
- microsatellite instability (2)
- mitochondrial DNA (2)
- molecular diagnostics (2)
- molecular imaging (2)
- mouse models (2)
- mutation (2)
- mutations (2)
- natural immunity (2)
- natürliche Antikörper (2)
- natürliche Immunität (2)
- neuroinflammation (2)
- obesity (2)
- organoids (2)
- oxidative stress (2)
- p53 (2)
- pancreatic cancer (2)
- plasma cells (2)
- positron emission tomography/computed tomography (2)
- postnatal development (2)
- principal component analysis (2)
- proteomics (2)
- radiotherapy (2)
- rat (2)
- receptor tyrosine kinases (2)
- regression analysis (2)
- regulatory T cells (2)
- senile lymphoproliferation (2)
- signal transduction (2)
- survival (2)
- targeted therapy (2)
- temozolomide (2)
- transcription (2)
- translocation (2)
- tumor immunology (2)
- tumor microenvironment (2)
- tumor suppressor gene (2)
- vestibular schwannoma (2)
- vitamin D (2)
- - (1)
- 16S-rRNA (1)
- 3D ex vivo models (1)
- 3D lung tumor tissue models (1)
- <sup>18</sup>F-FDG (1)
- <sup>68</sup>Ga-Pentixafor (1)
- AD-AID (1)
- ADAM9 (1)
- ADP-ribosylation toxins (1)
- AICDA (1)
- AID-ΔE4a (1)
- AIDS (1)
- AIRE (1)
- AKT-signaling (1)
- ALCL (1)
- ALK-1 (1)
- AMACR (1)
- AOM/DSS (1)
- APECED (1)
- ATF5 (1)
- ATG7 (1)
- ATM (1)
- Aberrationen (1)
- Activation (1)
- Activation induced cell death/AICD (1)
- Adamantiades-Behçet disease (1)
- Adult (1)
- Akute Ösophagusnekrose (1)
- Allogenic hematopoietic stem cell transplantation (1)
- Alpha therapy (1)
- Alter (1)
- Alzheimerkrankheit (1)
- Amplicon Sequencing (1)
- Anergy (1)
- Aneuploidie (1)
- Antibodies (1)
- Antigen CD30 (1)
- Antigen CD8 (1)
- Antiparanodal Autoantibodies (1)
- Aphthae (1)
- Apoptose-Resistenz (1)
- Apoptoseinduktion (1)
- Appendizitis (1)
- Autoantikörper (1)
- Autoimmune diseases (1)
- Autoimmunerkrankung (1)
- Autoimmungastritis (1)
- Autoimmunkrankheit (1)
- Autoimmunregulator (1)
- Autoregulation (1)
- B Lymphocytes (1)
- B cell lymphoma (1)
- B cell malignancies (1)
- B lymphocytes (1)
- B-Lymphozyt (1)
- B-Lymphozyt-Tumor (1)
- B-MYB (1)
- B-Zell Lymphome (1)
- B-Zell-Leukämie (1)
- B-Zell-Rezeptor (1)
- B-Zellen Differenzierung (1)
- B-cell Lymphome (1)
- B-cell differentiation (1)
- B-cells (1)
- B-lymphocytes (1)
- BAC-Konstrukt (1)
- BAC-construct (1)
- BARB-4 (1)
- BCL1 rearrangement (1)
- BCL1-Rearrangement (1)
- BCL2 (1)
- BIRC7 (1)
- BLIMP1 (1)
- BRMS1 (1)
- Barrett-Ösophagus (1)
- Bauchfellentzündung (1)
- Bauchspeicheldrüsenkrebs (1)
- Bcl-2-Gen (1)
- Bcl-2-gene (1)
- Behçet’s disease (1)
- Bevacizumab (1)
- Bioluminescence imaging (1)
- Biomarker (1)
- Bisphosphonate (1)
- Blasenkrebs (1)
- Blimp-1 (1)
- Blimp1 (1)
- Blinddarmentzündung (1)
- Bone chips (1)
- Bone marrow cells (1)
- Bone marrow transplantantation (1)
- Bone marrow transplantation (1)
- Braak (1)
- Breast-cancer (1)
- Bruton Tyrosine Kinase (1)
- Burkitt (1)
- B‐cell lymphoma (1)
- C-Myc (1)
- C/EBP (1)
- C/EBP-Beta (1)
- C/EBPβ (1)
- C3 (1)
- CABG-operation (1)
- CBP (1)
- CCR7 (1)
- CD 27 (1)
- CD-Marker (1)
- CD/metabolism (1)
- CD117 (1)
- CD133 (1)
- CD27 (1)
- CD274 (1)
- CD30-Rezeptor (1)
- CD319 (1)
- CD4+ (1)
- CD40 ligand (1)
- CD5-positive B-Lymphozyten (1)
- CD56 (1)
- CD8 (1)
- CD9 (1)
- CFR-1 (1)
- CHAC1 (1)
- CIITA (1)
- CK5 (1)
- COVID-19 (1)
- CRC (1)
- CRISPR-Cas9 (1)
- CRISPR/Cas-Methode (1)
- CS1 (1)
- CSF (1)
- CTL function (1)
- CTNNB1 (1)
- CX5461 (1)
- CXCL5 (1)
- CXCL8 (1)
- CXCR1 (1)
- CXCR4/SDF-1 (1)
- CXCR5 (1)
- CXCR7 (1)
- CYP24A1 (1)
- CYP2W1 (1)
- Calcineurin (1)
- Calcium (1)
- Cancer (1)
- Cancer genetics (1)
- Cancer treatment (1)
- Cancer/Testis Antigene (1)
- Cancer/Testis antigen (1)
- Candida (1)
- Carcinogenese (1)
- Cartilage Oligomeric Matrix Protein (1)
- Caspase 12 (1)
- Ccl2 (1)
- Chains (1)
- Checkpoint-Inhibitor (1)
- Chemokin (1)
- Chemokin CXCL10 (1)
- Chemokine (1)
- Chemokinrezeptor (1)
- Chemotherapy (1)
- Childhood (1)
- Chromosom 9 (1)
- Chromosome 18 (1)
- Chromosomenaberration (1)
- Cisplatin (1)
- Clonality (1)
- Clonality analysis (1)
- Cocktail (1)
- Cushings syndrome (1)
- Cushing’s disease (1)
- Cytogenetik (1)
- Cytotoxizität (1)
- DCIS (1)
- DCR1 (1)
- DEL(5Q) (1)
- DHAP (1)
- DLBCL multilobated (1)
- DLBCL multilobuliert (1)
- DLBL (1)
- DNA hypermethylation (1)
- DNA methylation (1)
- DNA-PK (1)
- DNS-Reparatur (1)
- DOTATOC (1)
- DT40 cells (1)
- DWI (1)
- Defined burkitts lymphoma (1)
- Delta Repertoire (1)
- Dendritic cells (1)
- Dendritische Zelle (1)
- Design (1)
- Diabetes mellitus (1)
- Diagnostik (1)
- Dickdarmkrebs (1)
- Differentielle Genexpression (1)
- Diffuse großzellige B-Zell Lymphome (1)
- Diffuses großzelliges B-Zell Lymphom (1)
- Diphosphonate (1)
- Durchflusszytometrie (1)
- E-Learning (1)
- EAHP/SH bone marrow workshop (1)
- EATCL (1)
- EBER in situ hybridization (1)
- EGF (1)
- EL-4 (1)
- EL-4 Zellen (1)
- ERM proteins (1)
- ETL (1)
- EZH1 (1)
- EZH2 (1)
- Endothel (1)
- Enteropathie-Typ (1)
- Entzündung (1)
- Enzephalitis (1)
- Epidemiological study (1)
- Epigenese (1)
- Epigenetics (1)
- Epigenetik (1)
- Epitope (1)
- Epstein-Ba (1)
- Epstein-Barr virus (1)
- Ewing-Sarkom (1)
- Extrafollikuläre Aktivierung (1)
- Extraocular eye muscles (1)
- F-19 MRI (1)
- FADD (1)
- FARS1 (1)
- FDG PET/CT (1)
- FGF-pathway (1)
- FINCA (1)
- FL (1)
- FL3B (1)
- FLT-PET (1)
- FTIR spectroscopy (1)
- Factor receptor (1)
- Fas (1)
- Fibrin glue (1)
- Fluoreszenzaktivierter Zellsortierer (1)
- Forskolin (1)
- Frequency (1)
- Frühdiagnostik (1)
- Frühphase (1)
- GABP (1)
- GATA-3 (1)
- GFAP (1)
- GIST (1)
- GLP-1 (1)
- GRP78 (1)
- GSH (1)
- Gallium (1)
- Gen-Anordnung (1)
- Genamplifikation (1)
- Gene (1)
- Gene-expression (1)
- Genetik (1)
- Genitoanal region (1)
- Genome wide analysis (1)
- Genregulation (1)
- Gewebemicroarray (1)
- Gewebeverlust (1)
- Glioma stem cells (1)
- Glykosylierung (1)
- Grad 3B (1)
- Grading (1)
- Graft-versus-host-disease (1)
- GvHD (1)
- GvL (1)
- Gvhd (1)
- H. pylori Gastritis (1)
- H.pylori gastritis (1)
- H2O2 (1)
- H3K27me3 (1)
- HD (1)
- HER2 conversion (1)
- HER2 targeted therapy (1)
- HER2-low (1)
- HHV8 (1)
- HNSC (1)
- HPK1 (1)
- HSC (1)
- Hals-Nasen-Ohren-Heilkunde (1)
- Hals-Nasen-Ohren-Tumor (1)
- Hans algorithm (1)
- Harnblasenkarzinom (1)
- Hautlymphom (1)
- Head (1)
- Head and neck cancers (1)
- Heavy chain mutations (1)
- Helicobacter (1)
- Helicobacter pylori (1)
- Helicobacter-pylori-Infektion (1)
- High-resolution (1)
- Hirntumor (1)
- Histologie (1)
- Histone deacetylase inhibition (1)
- Histopathology (1)
- Hitzeschockprotein (1)
- Hodgkin-Lymphom (1)
- Hodgkin´s disease (1)
- Hsp90 (1)
- Human antibodies (1)
- Humane Antikörper (1)
- Hybridom (1)
- Hypercortisolism (1)
- Hypermutation (1)
- Hypopharynxkarzinom (1)
- IDH (1)
- IDH1/2 (1)
- IFN (1)
- IFN-γ (1)
- IGF1R (1)
- IGF2BP3 (1)
- IL-10 (1)
- IL-17 (1)
- IL-2 (1)
- IL-4 (1)
- IL-5 (1)
- IL2 (1)
- IMP3 (1)
- IR (1)
- IRF4 (1)
- Ibrutinib (1)
- IgG4 (1)
- IgM (1)
- IgM isotyp (1)
- Images (1)
- Immun-Checkpoint (1)
- Immunbiologie (1)
- Immunfluoreszenz (1)
- Immunhistologie (1)
- Immunisierung (1)
- Immunität <Medizin> (1)
- Immunmodulation (1)
- Immunology (1)
- Immunoreceptors (1)
- Immunosuppression (1)
- Immunphänotyp (1)
- Immunreaktion (1)
- Immunrezeptoren (1)
- In-vivo (1)
- Inflammation (1)
- Intestinal Intraepithelial Lymphocy (1)
- Intrakranielle Blutung (1)
- Involution (1)
- Iron-oxide (1)
- Irradiation (1)
- Isoformen (1)
- JAK inhibitor (1)
- JNK (1)
- JUN (1)
- KIT (1)
- KRAS (1)
- KRAS biomarker signatures (1)
- Kaposi sarcoma (1)
- Keimzelltumor (1)
- Keimzentrumsreaktion (1)
- Keratine (1)
- Keratinozyt (1)
- Ki-67 (1)
- KiSS1 (1)
- Kidney cancer (1)
- Kiefernekrosen (1)
- Killerzelle (1)
- Kindesalter (1)
- Klarzellsarkom (1)
- Klassifikation (1)
- Klonale Evolution (1)
- Klonalitaetsanalysen (1)
- Klonalität (1)
- Knochenmetastase (1)
- Knochensialoprotein (1)
- Knock-out-Mäuse (1)
- Kolonkarzinom (1)
- Komparative Genomische Hybridisierung (1)
- Komparative genomische Hybridisierung (1)
- Krebstherapie (1)
- Kreuzreaktion (1)
- LESA (1)
- LGA (1)
- LITAF (1)
- LM-1 (1)
- Lagerungsmedium (1)
- Laminin (1)
- Langfristige Prognose (1)
- Larynxkarzinom (1)
- Lateral suboccipital craniectomy (1)
- Lesions (1)
- Leukoplakia (1)
- Leukoplakie (1)
- Lichen planus (1)
- Lichen ruber planus (1)
- Ligand (1)
- Lipom (1)
- Liposarkom (1)
- Lipotoxizität (1)
- Lokalisation (1)
- Low grade Astrocytoma (1)
- Lung-cancer (1)
- Lymph2Cx assay (1)
- Lymphadenitis (1)
- Lymphdrüse (1)
- Lymphocytes (1)
- Lymphomas (1)
- Lymphozyt (1)
- Lymphsystem (1)
- MAGE A3 (1)
- MAGE-A (1)
- MAGE-A-Antigene (1)
- MAGE-A-antigens (1)
- MALT lymphoma (1)
- MALT-Lymphome (1)
- MALT-Typ Lymphome (1)
- MALT-type lymphoma (1)
- MALT1-Gen (1)
- MALT1-gene (1)
- MAPK (1)
- MCL (1)
- MDS (1)
- MEF2D (1)
- MEK/ERK-signaling (1)
- MGMT (1)
- MGMT promoter methylation (1)
- MHC (1)
- MITF-low (1)
- MIZ1 (1)
- MMP2 (1)
- MMP9 (1)
- MRSA (1)
- MTB (1)
- MTCH2 (1)
- MTX (1)
- Malignancies (1)
- Malt (1)
- Mantelzellen (1)
- Mantelzelllymphom (1)
- Marginal zone lymphomas (1)
- Marginalzonen-B-Zell-Lymphom (1)
- Marginalzonen-Lymphome (1)
- Masaoka (1)
- Maschinelles Lernen (1)
- Mediastinum (1)
- Medical research (1)
- Mensch (1)
- Merlin (1)
- Metastases (1)
- Mikroglia (1)
- Mikrosatelliten (1)
- Mikrosatelliten-Instabilität (1)
- Milz (1)
- Mismatch (1)
- Molecular pathogenesis (1)
- Molekulargenetik (1)
- Monoklonaler Antikrper (1)
- Morphometrie (1)
- Mukosa-assoziiertes lymphatisches Gewebe (1)
- Multigentests (1)
- Multiple Sklerose (1)
- Mundhöhlentumor (1)
- Muskelzelle (1)
- Mutation (1)
- MyD88 (1)
- Myasthenia gravi (1)
- Myb-MuvB (1)
- Myc (1)
- Myeloma cells (1)
- Myelomas (1)
- Mykose (1)
- Mysthenia Gravis (1)
- N-Glykosylierungsmotive (1)
- N-glycosylation sites (1)
- NEC (1)
- NET (1)
- NF-KAPPA-B (1)
- NF-\(\kappa\)B pathway (1)
- NF-κB (1)
- NFAT in EAE (1)
- NFATc (1)
- NFATc1 sumoylation (1)
- NFATc1/αA (1)
- NFATc3 (1)
- NFATs (1)
- NFE2L2 (1)
- NFkappaB (1)
- NGS (1)
- NHLRC2 (1)
- NIH-3T3 (1)
- NLPHL (1)
- NORM-1 (1)
- NR3C1 (1)
- NSG (1)
- NSG-SGM3 (1)
- NY-ESO 1 (1)
- Natürliche Killerzelle (1)
- Nebennierenrinde (1)
- Nebennierenrindenkrebs (1)
- Nestin (1)
- Neurodegeneration (1)
- Nicotinischer Acetylcholinrezeptor (1)
- Nierenzellcarcinom (1)
- Nodo-parandopathy (1)
- Non Hodgkin Lymphoma (1)
- Non Hodgkin Lymphome (1)
- Non-Hodgkin Lymphome (1)
- Non-Hodgkin-Lymphome (1)
- Nrf2 (1)
- Nuclear Factor of Activated T cells (NFAT) (1)
- Nuclear expression (1)
- Nur77 (1)
- OBF-1 OCA-B (1)
- OCT-1-deficient mice (1)
- Oncotype DX® (1)
- OncotypeDX (1)
- OncotypeDX\(^{®}\) (1)
- Oral Precancer (1)
- Oral mucosa (1)
- Oral squamous cell carcinoma (1)
- Organoids (1)
- Osteoarthrose (1)
- Osteogeneration (1)
- Osteopontin (1)
- PAI-1 (1)
- PAM-1 (1)
- PAT-LM1 (1)
- PAT-SM6 (1)
- PCDHGC3 (1)
- PCI-32765 (1)
- PD-1 (1)
- PI3K (1)
- PKA (1)
- PLAG1 rearrangement (1)
- POLKADOTS (1)
- PRDI-BF1 (1)
- PRRT (1)
- PTCL NOS (1)
- PTEN (1)
- Paraffin (1)
- Parkinson (1)
- Parkinsons disease (1)
- Parkinson’s disease (1)
- Particles (1)
- Pathohistologie (1)
- Pathway (1)
- Pentixafor (1)
- Phylogenetik (1)
- Phänotyp (1)
- Plaques und Tangels (1)
- Plasmozytom (1)
- Plattenepithelkarzinom (1)
- Polyadenylierung (1)
- Polymerase-Kettenreaktion (1)
- Positron emission tomography (1)
- Positronen-Emissions-Tomografie (1)
- Posttranskriptionelle Regulation (1)
- Pou2af1 (1)
- Primär kutane Marginalzonen-Lymphome (1)
- Primär kutanes Lymphom (1)
- Profiling (1)
- Prog (1)
- Prognosis (1)
- Proliferation index (1)
- Proliferationsindex (1)
- Promoter (1)
- Promotor (1)
- Promotor <Genetik> (1)
- Prophylaxe (1)
- Prostata-DNA-Datenbank (1)
- Prostatakarzinom (1)
- Protein-DNA-Interaktion (1)
- Protein-Protein-Interaktion (1)
- Präkanzerose (1)
- Präkanzerosen (1)
- R-CHOP (1)
- RCC (1)
- RNA Expression (1)
- RNA probe (1)
- RNA-Sequenzierung (1)
- RNAPOL1 (1)
- RNAScope (1)
- ROS (1)
- RPS27 (1)
- RYGB (1)
- Rac (1)
- Raf (1)
- Random Forest (1)
- Rats (1)
- Receptor-Tyrosine Kinases (1)
- Regulatorgen (1)
- Regulatory-cells (1)
- Reifung (1)
- Renal cell carcinoma (1)
- Restriktionsfragmentlängenpolymorphismus (1)
- Retroperitoneum (1)
- Retroviraler Gentransfer (1)
- Rezeptor-Expression (1)
- Rezeptor-Tyrosinkinasen (1)
- Rhabdomyosarkom (1)
- Rheumatoid arthritis (1)
- Rheumatoide Arthritis (1)
- Rho-GTPases (1)
- Ribosomale RNS (1)
- Richter's syndrome (1)
- Richter-Syndrom (1)
- Risiko (1)
- Risikofaktoren (1)
- Risk factors (1)
- Rituximab plus (1)
- Riutximab (1)
- Rotatorenmanschettensyndrom (1)
- S-Phase-Fraktion (1)
- S-phase fraction (1)
- SAM-6 (1)
- SARS-CoV-2 (1)
- SB332235 (1)
- SGN-35 (1)
- SHARP-Screening (1)
- SIV (1)
- SLC7A11 (1)
- SOAT1 (1)
- SSTR (1)
- STEAP-1 (1)
- Sarkom (1)
- Schleimhaut (1)
- Schleimhaut-Ulzera (1)
- Schütteltrauma (1)
- Senile Lymphoproliferation (1)
- Sequenzdaten (1)
- Skelettmuskulatur (1)
- Soft-tissue infection (1)
- Sox9 (1)
- Speicheldrüsenkrebs (1)
- Speiseröhre (1)
- SphK1 (1)
- Spinal dissemination (1)
- Spindle cell (1)
- Spleen (1)
- Sporadic Alzheimer’s disease (1)
- Sporadische Alzheimer-Demenz (1)
- Sprue (1)
- Squamous cell carcinoma (1)
- Staging (1)
- Stammzelltransplantation (1)
- Stanzbiopsie (1)
- Staphylococcus aureus (1)
- Staphylococcus aureus immune response (1)
- Starry Sky (1)
- Sternberg-Riesenzelle (1)
- Sunitinib (1)
- Suppression (1)
- Surgery (1)
- Survival (1)
- Synovialmembran (1)
- Synovialsarkom (1)
- T Lymphocytes (1)
- T Zellen (1)
- T cell differentiation (1)
- T cell receptors (1)
- T helper cells (1)
- T lymphocyte (1)
- T(H)17 cells (1)
- T-Helfer Zellen (1)
- T-Lymphozyt info (1)
- T-Zell-Entwicklung (1)
- T-Zell-Lymphom (1)
- T-Zell-Marker (1)
- T-Zell-Reifung (1)
- T-Zell-Rezeptor (1)
- T-Zelldifferenzierung (1)
- T-cell non-Hodgkin's lymphomas (1)
- T-cell receptor (1)
- T-cell transfer (1)
- T-cells (1)
- T-follicular regulatory cell (1)
- T-lymphocytes (1)
- TAD-A (1)
- TCR signaling cascade (1)
- TGF-alpha (1)
- TP53 (1)
- TP53 mutations (1)
- T\(_{reg}\) and Foxp3 (1)
- Targeted Therapies (1)
- Targets (1)
- Telepathologie (1)
- Temozolomide (1)
- Th (1)
- Th17 (1)
- Therapie (1)
- Thomas (Arzt) (1)
- Thymocytes (1)
- Thymoma (1)
- Thymome (1)
- Thymopoese (1)
- Thymuskrankheit (1)
- Tissue-Microarray-Technik (1)
- Tlymphozyten (1)
- Tolerance (1)
- Toleranz <Biologie> (1)
- Tonsilla (1)
- Tracking (1)
- Transcription factors (1)
- Transcription-factor (1)
- Transkription <Genetik> (1)
- Transkriptionfaktoren (1)
- Transkriptionsfaktor NF-KappaB (1)
- Transkriptionsfaktor info (1)
- Translational research (1)
- Translokation (1)
- Translokation t(11;14)(q13;q32) (1)
- Translokation t(11;18) (1)
- Transplantat-Wirt-Reaktion (1)
- Transplantatabstoßung (1)
- Tregs (1)
- Trisomie (1)
- Tumor Microenvironment (1)
- Tumor Treating Fields (TTFields) (1)
- Tumor-necrosis-factor (1)
- Tumorantigen (1)
- Tumorimmunity (1)
- Tumorimmunität (1)
- Tumornephrektomie (1)
- Tumorprogression (1)
- Tumorzell-Migration (1)
- Tumour markers (1)
- Typ 1 Muskelfasern (1)
- Tyrosine kinase inhibition (1)
- UMAP (1)
- USP8 (1)
- USP9X (1)
- UV-Strahlung (1)
- Urothelkarzinom (1)
- Usage (1)
- Uveitis (1)
- VDR (1)
- VH-JgG Mutationen (1)
- Vascular endothelial Growth Factor (1)
- Venenlagerung (1)
- Verlust der Heterozygosität (1)
- Vielfalt (1)
- Virtual Microscopy (1)
- Virtuelle Mikroskopie (1)
- Vitamin-K-Mangel-Blutung (1)
- Vorhersage (1)
- WHO (1)
- WHO-Klassifikation (1)
- WNT signaling (1)
- WTAP (1)
- Waldeyer-Ring (1)
- Waldeyer´s ring (1)
- Waldeyer’s tonsillar ring (1)
- Wilms tumour (1)
- XIAP (1)
- YAP (1)
- Zellmigration (1)
- Zelltod (1)
- Zellzyklus (1)
- Zentroblastisches Lymphom (1)
- Zytokeratin (1)
- [18F]FDG-PET-CT (1)
- [18F]Fluorodeoxythymidine (1)
- [\(^{68}\)Ga] pentixafor (1)
- [\(^{68}\)Ga]Pentixafor (1)
- \(^{68}\)Ga-Pentixafor (1)
- abdominal lymph node metastases (1)
- aberrations (1)
- abnormalities (1)
- actin (1)
- actin filament (1)
- actin filaments (1)
- activation (1)
- acute esophageal necrosis (1)
- acute graft-versus host disease (1)
- acute graft-versus-host disease (1)
- acute lymphoblastic leukemia (1)
- acute lymphocytic leukaemia (1)
- acute myeloid leukaemia (1)
- acute myeloid leukemia (1)
- adenomas (1)
- adenosine kinase (1)
- adhesion (1)
- adrenal glands (1)
- adrenal tumor (1)
- adrenocortical (1)
- adrenocortical cancer (1)
- adrenocortical tissues (1)
- adrenocortical tumors (1)
- affinity (1)
- aggressive B‐cell lymphoma (1)
- allergy (1)
- allogenic stem cell transplantation (1)
- allografts (1)
- alternative splicing (1)
- aluminum granuloma (1)
- aminoacyl‐tRNA synthetases (1)
- amplifications (1)
- amyloidoma (1)
- amyloidosis (1)
- anaplasia (1)
- anaplastic large T-cell-lymphoma (1)
- anaplastic large cell lymphoma (1)
- anaplastic large cell lymphoma (ALCL) (1)
- anaplastic medulloblastoma (1)
- anaplastisch-großzellige T-Zell-Lymphome (1)
- aneuploidy (1)
- aneusomy (1)
- angeborenes Immunsystem (1)
- annecin-V (1)
- anti-CD30 drug conjugate (1)
- anti-inflammatory cytokines (1)
- antibodies (1)
- antibody (1)
- antibody-mediated (1)
- antigen loss (1)
- antigens (1)
- antikörpervermittelt (1)
- antioxidant function (1)
- aortic adventitia (1)
- aortokoronarer Venenbypass (1)
- apoptosis, Myc (1)
- appendicitis (1)
- arteriovenous loop (1)
- atopic dermatitis (1)
- atrial natriuretic peptide (1)
- aurora kinase A polymorphism (1)
- aurorakinase B (1)
- autoantibodies (1)
- autoantibody (1)
- autoantigen (1)
- autoimmune regulator (1)
- autoimmunregulator (1)
- autoimmuns gastitis (1)
- autologous transplantation (1)
- autophagy (1)
- axonally transported proteins (1)
- azacitidine (1)
- b-cell lymphoma of the MALT type (1)
- b-cell lymphomas (1)
- b-cell receptor (1)
- bacterial toxins (1)
- behavior (1)
- benige tumor (1)
- beta-catenin (1)
- binding (1)
- binding proteins (1)
- biofluid (1)
- bioinformatic clustering (1)
- biological sciences (1)
- biomarker prediction (1)
- biopsy (1)
- biosynthesis (1)
- bisphosphonate (1)
- blood–brain barrier (1)
- bone disease (1)
- bone marrow biopsy (1)
- bone marrow cells (1)
- bone marrow–spleen–liver large B‐cell lymphoma (1)
- bone metastases (1)
- bone metastasis (1)
- bone sialoprotein (1)
- boolean in silico models (1)
- botulinum C2 toxin (1)
- breast carcinoma (1)
- buparlisib (1)
- c-MYC (1)
- c-kit (1)
- c-myc (1)
- c/ebp (1)
- cAMP (1)
- cadaver multiorgan preservation (1)
- calcium (1)
- cancer care (1)
- cancer detection (1)
- cancer diagnosis (1)
- cancer metabolism (1)
- cancer of unknown primary (CUP) (1)
- cancer therapy (1)
- cancer treatment (1)
- carcinogenesis (1)
- carcinoma (1)
- carcinoma metastases to pancreas (1)
- cardiac transplantation (1)
- cardiomyocyte proliferation (1)
- cartilage oligomeric matrix protein (1)
- caspase-3 (1)
- catenin (1)
- caveolin-1 (1)
- cell binding (1)
- cell cycle and cell division (1)
- cell death (1)
- cell of origin (1)
- cells (1)
- cellular uptake (1)
- centroblastic lymphoma of the multilobated subtype (1)
- cerebellum (1)
- cerebral cortex (1)
- cerebropulmonary disease (1)
- cetuximab (1)
- checkpoint inhibition (1)
- chemokine receptor-4 (1)
- chemokinereceptor (1)
- childhood (1)
- childhood interstitial lung disease (1)
- children (1)
- children´s interstitial lung disease (chILD) lipoid pneumonia (1)
- cholesterol pneumonia (1)
- cholesterol pneumonitis (1)
- chromatin (1)
- chromosome 18 (1)
- chromosome 9 (1)
- chromosomes (1)
- chronic IBD model (1)
- chronic lymphocytic leukemia (1)
- chronische B-Zell Leukaemie (1)
- chronophin (1)
- classical Hodgkin lymphoma (1)
- cleavage (1)
- clonal evolution (1)
- clonality (1)
- clostridium botulinum (1)
- coactivator OBF-1 (1)
- coated vesicles (1)
- cofilin (1)
- colorectal carcinoma (1)
- combined immunodeficiency (1)
- combined therapy (1)
- complement system (1)
- complex (1)
- confocal Raman imaging (1)
- consensus DNA (1)
- cross-priming (1)
- cross-reaction (1)
- cutaneous T-cell-lymphoma (1)
- cycle (1)
- cyclophsophamide (1)
- cyclosporine A (1)
- cytokeratin (1)
- cytotoxicity (1)
- damage (1)
- damage responses (1)
- deformation (1)
- deletions (1)
- diagnosis (1)
- diagnostics (1)
- diffuse large B-Cell lymphoma (1)
- diffuse large B‐cell lymphoma (1)
- disease (1)
- distinct (1)
- down regulation (1)
- drug abuse (1)
- drug resistance (1)
- drug therapy (1)
- eGFP (1)
- early (1)
- early breast cancer (1)
- early diagnosis (1)
- echocardiography (1)
- ectopic lymphoid follicle (1)
- effector Treg (eTreg) (1)
- egfr (1)
- ejection fraction (1)
- embryonic lethality (1)
- encephalitis (1)
- encephalitis lethargica (1)
- endothelium (1)
- enhancer (1)
- enteropathy-type (1)
- ependyoma (1)
- ephitelial cells (1)
- epigenetics (1)
- epithelial markers (1)
- epithelium (1)
- extracorporeal membrane oxygenation (1)
- extrafollicular activation (1)
- extramedullary disease (1)
- features (1)
- ferroptosis (1)
- fetaler Acetylcholinrezeptor (1)
- fibroblast activation protein (1)
- fixation (1)
- fluorenscence (1)
- fluorescence in situ hybridisation (1)
- fluorescent-in -situ-hybridization (1)
- foetal typ acetylcholine receptor (1)
- follicular T helper cells (1)
- follicular lymphoma reactive germinal centers (1)
- follicular regulatory T cell (1)
- follikuläre Lymphome erhaltene reaktive Keimzentren (1)
- follikuläre regulatorische T-Zelle (1)
- follikulärer (1)
- forecasting (1)
- formalin (1)
- formalin-fixed (1)
- formalin-fixiert (1)
- functional characterization (1)
- fungal infection (1)
- gRNA-only (1)
- gastric bypass (1)
- gastrointestinal infections (1)
- gefitinib (1)
- genetic loci (1)
- genetics (1)
- genomic aberrations (1)
- germinal center formation (1)
- germline mutation (1)
- gesolin function (1)
- glioblastoma multiforme (GBM) (1)
- glucocorticoid excess (1)
- glutaminase inhibition (1)
- goldfish optic nerve (1)
- group 3 (1)
- growth (1)
- growth pattern (1)
- growth patterns (1)
- growth-associated protein (1)
- großzellige (1)
- gut–liver axis (1)
- head and neck (1)
- head and neck cancer (1)
- heart (1)
- heart failure (1)
- heatshockprotein (1)
- helicobacter (1)
- helicobacter pylori (1)
- helper T cells (1)
- helper T-cells (1)
- hematopoiesis (1)
- hematopoietic stem cells (1)
- hemophagocytosis (1)
- hepcidin (1)
- high numbers (1)
- high-dose chemotherapy (1)
- high-resolution analysis (1)
- high-risk Prostate Cancer (1)
- high‐grade B‐cell lymphoma (1)
- hippocampal stem cells (1)
- histopathology (1)
- hnRNP K (1)
- hormones (1)
- human (1)
- human antibodies (1)
- human brain (1)
- human cerebral endothelial cells (1)
- human genome (1)
- human monoclonal antibodies (1)
- human monoclonal antibody LM-1 (1)
- human monoclonal antibody PAM-1 (1)
- humane Antikörper (1)
- humane monoklonale Antikörper (1)
- humaner monoklonaler Antikörper LM-1 (1)
- humaner monoklonaler Antikörper PAM-1 (1)
- humanized hemato-lymphoid mice (1)
- humanized mice (1)
- hybridization (1)
- hyper-IgM syndrome type 2 (HIGM2) (1)
- hypercortisolism (1)
- hypermutation (1)
- iiron transporter (1)
- immune cells (1)
- immune check inhibitor (1)
- immune checkpoint blockade (1)
- immune checkpoint inhibitor (ICI) (1)
- immune evasion (1)
- immune infiltration (1)
- immune system (1)
- immunhistochemical analysis of DLBCL (1)
- immunhistochemisch (1)
- immunhistochemische Analyse von DLBCL (1)
- immunity (1)
- immunocytochemistry (1)
- immunofuorescence double staining (1)
- immunoglobulin promoters (1)
- immunoglobuline (1)
- immunohistochemisty (1)
- immunohistological expression analysis (1)
- immunology and microbiology section (1)
- immunophenotype (1)
- immunotherapeutics (1)
- in silico analysis (1)
- in-situ-Hybridisierung (1)
- in-situ-hybridization (1)
- in-vitro (1)
- in-vivo (1)
- independent predictor (1)
- induction (1)
- induction of apoptosis (1)
- inflammation-induced tissue demage (1)
- innate Immunität (1)
- innate antibody (1)
- integrated stress response (1)
- integrin (1)
- interaction (1)
- interleukin-8 (1)
- interleukins (1)
- intestine (1)
- intracranial bleeding (1)
- intraosseous (1)
- intravascular large B‐cell lymphoma (1)
- invasion (1)
- involution (1)
- involvement (1)
- iron in parkinsonism (1)
- iron model (1)
- iron pathology (1)
- isoforms (1)
- karyotype (1)
- kidney cancer (1)
- kinase (1)
- kinases (1)
- kinetic mechanism (1)
- knock down (1)
- knock out mice (1)
- kolorektales Karzinom (1)
- komparative genomische Hybridisierung (1)
- kras (1)
- kras-Mutation (1)
- large cell transformation (1)
- latency type (1)
- lck (1)
- lesions (1)
- leukemia (1)
- lichen planus (1)
- lineage (1)
- lineage differentiation (1)
- lipid droplets (1)
- lipids (1)
- lipoblastoma (1)
- lipoid pneumonitis (1)
- lipotoxicity (1)
- liquid biopsy (1)
- liraglutide (1)
- livin (1)
- lung fibrosis (1)
- lymph node (1)
- lymph node stromal cells (1)
- lymph node transplantation (1)
- lymphatische Tumoren (1)
- lymphocyte (1)
- lymphocyte activation (1)
- lymphocyte differentiation (1)
- lymphocytes (1)
- lymphohistiocytosis (1)
- lymphoid aggregate (1)
- lymphoid hyperplasia (1)
- lymphoid-tissue (1)
- lymphoid-tissue lymphomas (1)
- lymphomas (1)
- mRNA expression (1)
- mTOR (1)
- major histocompatibility complex (1)
- malignancies (1)
- malt lymphoma (1)
- mammalian cells (1)
- mandible (1)
- mantel cell lymphoma (1)
- marcophages (1)
- marginal zone-B-cell-Lymphoma (1)
- marrow transplantation (1)
- mass cytometry (1)
- mast cells (1)
- mastocytosis (1)
- measles virus (1)
- mediastinum (1)
- medical research (1)
- medicine (1)
- membrane topology (1)
- membrane translocation (1)
- memory B cells (1)
- meningeal inflammation (1)
- meningioma (1)
- mesenchymal markers (1)
- mesenteric lymph node (1)
- mesentery (1)
- messenger-RNA transport (1)
- metabolism (1)
- metagenomics (1)
- metastasis-associated in colon cancer 1 (MACC1) (1)
- methylation (1)
- miR-126 (1)
- miR-21 (1)
- microRNA-221 (1)
- microglia (1)
- microsatellite analysis (1)
- microsatellites (1)
- microvessel permeability (1)
- mikrobielle Diversität (1)
- mild hypothermia (1)
- mitochondriale DNA (1)
- mitochondriale DNA-Deletionen (1)
- mitosis (1)
- mitotane (1)
- mitotic genes (1)
- molecular marker (1)
- molecular subtypes (1)
- monoklonale Antikörper (1)
- monoklonaler Antikörper (1)
- morphometry (1)
- mouse model (1)
- mtDNA (1)
- mucosa-associated lymphatic tissue (1)
- mucosal ulcers (1)
- multifocal growth (1)
- multigene-array (1)
- multilobulierte centroblastische Lymphome (1)
- multiple Sclerosis immunomodulation Natalizumab (1)
- multiple sclerosis (1)
- multivariate Prognoseanalyse (1)
- multivariate data analysis (1)
- multi‐organ disease (1)
- murine homolog (1)
- mutant p53 (1)
- mutational targeting (1)
- myasthenia (1)
- mycosis fungoides (1)
- naive T-cell gene editing (1)
- natural IgG antibody (1)
- natural IgM antibodies (1)
- natural antibodies (1)
- natürliche IgM-Antikörper (1)
- natürlicher IgG-Antikörper (1)
- negative selection (1)
- nephroblastoma (1)
- nervous system (1)
- network (1)
- neurodegeneration (1)
- neurodegenerative disease (1)
- neuroendocrine tumor (1)
- neurogene Schädigung (1)
- neuromelanin (1)
- neuromucular disorders (1)
- neurooncology (1)
- neuropathology (1)
- neuroscience (1)
- neurotoxicity (1)
- neurovascular unit (1)
- neutral loss (1)
- next generation sequencing (1)
- niche (1)
- nicotinic acetylcholine receptor (1)
- nodal (1)
- nodal peripheral T-cell lymphoma (1)
- nodales peripheres T-Zell-Lymphom (1)
- nodular lymphcyte (1)
- non-GCB-Subtyp (1)
- non-GCB-like (1)
- non-Hodgkin lymphoma (1)
- non-hodgkin lymphoma (1)
- non-hodgkin-lymphoma (1)
- non-small cell lung cancer (1)
- noncoding RNAs (1)
- normal adrenal glands (1)
- notch signaling (1)
- nuclear DNA content (1)
- nukleare DNA-Inhalt (1)
- nur77 (1)
- obinutuzumab (1)
- octreotide (1)
- olfactory bulb (1)
- oncogene (1)
- organotypic hippocampal slice cultures (OHSC) (1)
- orthotopic xenograft (1)
- osteoarthritis (1)
- osteonecrosis of jaw (1)
- outcomes research (1)
- outreach (1)
- oxidativer Stress (1)
- p300 (1)
- p53 expression (1)
- p53-dependent apoptosis (1)
- p53-inducible regulator (1)
- pFADD (1)
- pan-RCC (1)
- panel sequencing (1)
- panel-sequencing (1)
- panniculitis (1)
- paraffin-eingebettet (1)
- paraffin-embedded (1)
- parathyroid carcinoma (1)
- parkinson’s disease (1)
- pathogenesis (1)
- pathohistology (1)
- pathology (1)
- pathway (1)
- patient access (1)
- patient survival (1)
- pediatric (1)
- pediatric lymphoma (1)
- pembrolizumab (1)
- peptide receptor radionuclide therapy (1)
- peptide receptor radionuclide therapy (PRRT) (1)
- peptide tyrosine tyrosine (PYY) (1)
- peptide tyrosine tyrosine 3-36 (PYY\(_{3-36}\)) (1)
- peripheral T-cell (1)
- peripheral T-cell lymphoma (1)
- periphere T-Zell-Lymphome (1)
- phosphatase 2A (1)
- phospholipase A(2) (1)
- plasmablasts (1)
- pleural mesothelioma (1)
- polyadenylation (1)
- post-mortem heart recovery (1)
- postencephalitic parkinsonism (1)
- posttranslational modification (1)
- posttranslationale Modifikation (1)
- potentiell therapeutisch relevante Proteine (1)
- precancerous lesions (1)
- precision oncology (1)
- prediction (1)
- primary bone marrow presentation (1)
- primary cell culture (1)
- primary cutaneous follicular B-cell lymphoma (1)
- primary cutaneous lymphoma (1)
- primary cutaneous marginal zone lymphomas (1)
- pro-inflammatory cytokines (1)
- prognostic factor (1)
- prognostic factors (1)
- prognostic marker (1)
- prognostic value (1)
- progressive multiple sclerosis (1)
- proliferation (1)
- prophylaxis (1)
- prostate cancer (1)
- prostate carcinoma (1)
- prostate gland DNA – database (1)
- prostate gland cancer (1)
- protein and mRNA expression (1)
- proteins (1)
- pseudocarcinomatous hyperplasia (1)
- pseudolymphoma (1)
- psoas muscle (1)
- psoriasis (1)
- radiation (1)
- radiation-induced migration (1)
- rag (1)
- raman spectroscopy (1)
- rare SNP (1)
- real world data (1)
- receptor expression (1)
- recurrence-free survival (1)
- refractory/relapsed lymphoma (1)
- regional development (1)
- regulatory T-cells (1)
- renal cancer (1)
- renal cell carcinoma (1)
- repeated surgery (1)
- resistance (1)
- resistance to apoptosis (1)
- restoration (1)
- retroperitoneal tumor (1)
- retroperitoneum (1)
- retroviral gene transfer (1)
- retroviral vector system (1)
- retrovirales Vektorsystem (1)
- reverse transcriptase-polymerase chain reaction (1)
- rhesus monkeys (1)
- rheumatoid arthritis (1)
- rheumatoiden Arthritis (1)
- ribosome (1)
- ribosyltransferase (1)
- risk (1)
- roquin (1)
- rotator-cuff injury (1)
- sFas (1)
- salivary gland (1)
- salivary gland neoplasia (1)
- salivary gland tumor (1)
- salivary gland tumors (1)
- salivary glands (1)
- sarcoma (1)
- scoring system (1)
- selective vulnerability (1)
- selektive Vulnerabilität (1)
- seminoma (1)
- senescence (1)
- senile Lymphoproliferation (1)
- serum (1)
- shaken baby syndrome (1)
- siv (1)
- slice culture (1)
- somatic hypermutation (1)
- somatic mutations (1)
- somatostatine (1)
- spinal-cord-injury (1)
- spleen (1)
- splice variant (1)
- sporadische Alzheimer-Demenz (1)
- squamous tumors (1)
- staphylococcal abscess (1)
- stem cell transplantation (1)
- stem-cells (1)
- stemness (1)
- stomach carcinoma (1)
- storage solution (1)
- stratification (1)
- subventricular zone (1)
- suppression (1)
- suppressor (1)
- surgery (1)
- surgical and invasive medical procedures (1)
- surgical treatment (1)
- systemic sclerosis (1)
- t cells (1)
- t(11;18)(q21;q21) (1)
- t(14;18)-negative follicular lymphoma (1)
- t(14;18)-negative follikuläre Lymphome (1)
- t-SNE (1)
- t-cell maturation (1)
- t-cell-lymphoma (1)
- target (1)
- target validation (1)
- targeted (1)
- targeted combination therapy (1)
- targeted sequencing (1)
- targeted therapies (1)
- tauopathy (1)
- telepathology (1)
- tetraspanin (1)
- tetraspanin protein (1)
- theranostics (1)
- therapeutic target (1)
- therapy response (1)
- thiol starvation (1)
- thymic epithelial tumor (1)
- thymitis (1)
- thymocytes (1)
- thymopoiesis (1)
- tissue preparation (1)
- tissuemicroarray (1)
- tofacitinib (1)
- transcript (1)
- transcription factor FOXP1 (1)
- transcriptional repression (1)
- transcriptome (1)
- transcriptomic analysis (1)
- transformation (1)
- translocation t(11;14)(q13;q32) (1)
- translocation t(11;18) (1)
- transplantation (1)
- trastuzumab (1)
- trastuzumab deruxtecan (1)
- treatment regimens (1)
- treg cells (1)
- triple-negative breast cancer (1)
- trisomy (1)
- tumor (1)
- tumor cell migration (1)
- tumor heterogeneity (1)
- tumor progression (1)
- tumor slice cultures (1)
- tumor specific antibody (1)
- tumor spheroids (1)
- tumor vaccination (1)
- tumor-vessel wall-interface model (1)
- tumorigenesis (1)
- tumormicroenvironment (1)
- tumors (1)
- tumorspecific (1)
- tumorspezifisch (1)
- tumorspezifische Antikörper (1)
- tumour heterogeneity (1)
- typ 1 muscle fibres (1)
- tyrosine kinase inhibitor (TKI) (1)
- uPA (1)
- ubiquitin (1)
- unspezifische Lymphadenitis (1)
- unsupervised clustering (1)
- up regulation (1)
- urinary bladder cancer (1)
- urothelial carcinoma (1)
- vascular wall stem and progenitor cells (1)
- vascularization model (1)
- vasculogenesis (1)
- vemurafenib (1)
- venetoclax (1)
- virus–iron interaction (1)
- visual clustering (1)
- vitamin D receptor (1)
- vitamin k deficiency bleeding (1)
- vitamin metabolism (1)
- von Economo (1)
- whole-exome sequencing (1)
- xxx (1)
- Östrogene (1)
- Überleben (1)
- Überlebenszeit (1)
- ɑ-Synuclein and iron (1)
- α-synuclein-specific T cells (1)
Institute
- Pathologisches Institut (323) (remove)
Schriftenreihe
Sonstige beteiligte Institutionen
- Center for Interdisciplinary Clinical Research, Würzburg University, Würzburg, Germany (1)
- Department of Paediatric Radiology, Institute of Diagnostic and Interventional Radiology, Josef-Schneider-Straße 2, Wuerzburg 97080, Germany (1)
- IZKF Nachwuchsgruppe Geweberegeneration für muskuloskelettale Erkrankungen (1)
- Lehrstuhl für Regeneration Muskuloskelettaler Gewebe (1)
- Muskuloskelettales Centrum Würzburg (MCW) (1)
Background
Treatment options for poorly differentiated (PDTC) and anaplastic (ATC) thyroid carcinoma are unsatisfactory and prognosis is generally poor. Lenvatinib (LEN), a multi-tyrosine kinase inhibitor targeting fibroblast growth factor receptors (FGFR) 1-4 is approved for advanced radioiodine refractory thyroid carcinoma, but response to single agent is poor in ATC. Recent reports of combining LEN with PD-1 inhibitor pembrolizumab (PEM) are promising.
Materials and Methods
Primary ATC (n=93) and PDTC (n=47) tissue samples diagnosed 1997-2019 at five German tertiary care centers were assessed for PD-L1 expression by immunohistochemistry using Tumor Proportion Score (TPS). FGFR 1-4 mRNA was quantified in 31 ATC and 14 PDTC with RNAscope in-situ hybridization. Normal thyroid tissue (NT) and papillary thyroid carcinoma (PTC) served as controls. Disease specific survival (DSS) was the primary outcome variable.
Results
PD-L1 TPS≥50% was observed in 42% of ATC and 26% of PDTC specimens. Mean PD-L1 expression was significantly higher in ATC (TPS 30%) than in PDTC (5%; p<0.01) and NT (0%, p<0.001). 53% of PDTC samples had PD-L1 expression ≤5%. FGFR mRNA expression was generally low in all samples but combined FGFR1-4 expression was significantly higher in PDTC and ATC compared to NT (each p<0.001). No impact of PD-L1 and FGFR 1-4 expression was observed on DSS.
Conclusion
High tumoral expression of PD-L1 in a large proportion of ATCs and a subgroup of PDTCs provides a rationale for immune checkpoint inhibition. FGFR expression is low thyroid tumor cells. The clinically observed synergism of PEM with LEN may be caused by immune modulation.
We examined the regulation of NFATc1 in different lymphomas and observed an inversed correlation between the methylation status and expression of NFATc1. Our data demonstrate that aberrant DNA methylation associated with chromatin remodeling within nfatc1 locus is a major mechanism for the repression of NFATc1 expression, suggesting that the DNA methylation-mediated transcriptional silencing of NFATc1 may be a critical event in the tumorogenesis of ALCLs and cHLs. Furthermore, the DNA methylation of human nfatc1 promoter region could be used as a novel biomarker of tumor progression. Our results indicate a close link between the loss of immunoreceptor signaling and NFATc1 expression in human lymphomas. For both ALCLs and cHLs, defects in immunoreceptor signaling have been described which result in a loss of receptor-mediated gene expression programs (Schwering et al., 2003; Bonzheim et al., 2004; Marafioti et al., 2004). In T cells, one indicator gene of these programs appears to be the nfatc1 gene whose expression is controlled by TCR signals (Chuvpilo et al., 2002a). In contrast, in T cells NFATc1 expression is unaffected by TCR signals, and NFATc2 was found to be expressed at normal levels in ALCLs and cHLs (L.K., unpubl. data). Moreover, the activity of NF-kappaB factors which can bind to certain NFAT binding sites and share a distantly-related DNA binding domain with NFATs is strongly elevated in cHL cells (Bargou et al., 1997; Hinz et al., 2001; Hinz et al., 2002) suggesting that NFATs and NF-kappaBs exert very different effects on generation and maintenance of Hodgkin’s lymhomas. However, it should be mentioned that in Burkitt’s and further B cell lymphomas in which NFATc1 proteins are strongly expressed and controlled by receptor signals (Kondo et al., 2003), they could exert a promoting function in tumor development. The genes of p53 family members p63 and p73 are prominent examples for mammalian genes whose products can act both as oncoproteins and tumor suppressor genes (Hibi et al., 2000; Stiewe and Putzer, 2002), and it is likely that more genes exist which encode both tumor suppressors and oncoproteins. It remains to be shown whether the nfatc1 gene is one of them.
Viele humane Sarkome sind durch spezifische chromosomale Translokationen oder typische genetische Amplifikationen definiert, welche in der Differentialdiagnostik insbesondere in Fällen, bei denen klinische Daten, Morphologie und Immunhistochemie alleine nicht ausreichend wegweisend sind. Die Formalin-fixiertem Paraffin-eingebetteten (FFPE-) Gewebe von 15 Ewing-Sarkomen, 4 Klarzellsarkomen, 9 Synovialsarkomen, 4 alveolären und 7 embryonalen Rhabdomyosarkomen und 25 Liposarkomen verschiedenen Subtyps wurden mittels Fluoreszenz-in-situ-Hybridisierung (FISH) untersucht um ein Sarkom-spezifisches FISH-Sondenset zur Detektion spezifischer chromosomaler Aberrationen in der Routinediagnostik zu etablieren. Es konnte gezeigt werden, dass die FISH in diesem Aufgabenfeld im Vergleich zur PCR ebenfalls eine hoch effiziente zytogenetische Methode mit hoher Spezifität und hohen positiven Vorhersagewerten mit dem Vorteil der unproblematischen Anwendung an FFPE-Geweben ist. Zur Detektion des Isochromosom 12p , i(12p), als Beispiel für komplexere chromosmale Aberrationen, wurden 7 FFPE-Gewebe aus Keimzelltumoren mit 12p- und 12q-detektierenden FISH-Sonden hybridisiert. Die Detektion des i(12p) konnte im Rahmen dieser Arbeit mittels FISH nicht erreicht werden. Zusammenfassend ist die FISH eine hoch effiziente zytogenetische Methode zur Detektion spezifischer chromosomaler Aberrationen in FFPE-Geweben aus humanen Sarkomen mit hoher Eignung zur Anwendung in der Routinediagnostik.
Background: There is much evidence that T cells are strongly involved in the pathogenesis of localized and systemic forms of scleroderma (SSc). A dysbalance between FoxP3+ regulatory CD4+ T cells (Tregs) and inflammatory T-helper (Th) 17 cells has been suggested. Methods: The study aimed (1) to investigate the phenotypical and functional characteristics of Th17 and Tregs in SSc patients depending on disease manifestation (limited vs. diffuse cutaneous SSc, dcSSc) and activity, and (2) the transcriptional level and methylation status of Th17- and Treg-specific transcription factors. Results: There was a concurrent accumulation of circulating peripheral IL-17-producing CCR6+ Th cells and FoxP3+ Tregs in patients with dcSSc. At the transcriptional level, Th17- and Treg-associated transcription factors were elevated in SSc. A strong association with high circulating Th17 and Tregs was seen with early, active, and severe disease presentation. However, a diminished suppressive function on autologous lymphocytes was found in SSc-derived Tregs. Significant relative hypermethylation was seen at the gene level for RORC1 and RORC2 in SSc, particularly in patients with high inflammatory activity. Conclusions: Besides the high transcriptional activity of T cells, attributed to Treg or Th17 phenotype, in active SSc disease, Tregs may be insufficient to produce high amounts of IL-10 or to control proliferative activity of effector T cells in SSc. Our results suggest a high plasticity of Tregs strongly associated with the Th17 phenotype. Future directions may focus on enhancing Treg functions and stabilization of the Treg phenotype.
NFATc1 supports imiquimod-induced skin inflammation by suppressing IL-10 synthesis in B cells
(2016)
Epicutaneous application of Aldara cream containing the TLR7 agonist imiquimod (IMQ) to mice induces skin inflammation that exhibits many aspects of psoriasis, an inflammatory human skin disease. Here we show that mice depleted of B cells or bearing interleukin (IL)-10-deficient B cells show a fulminant inflammation upon IMQ exposure, whereas ablation of NFATc1 in B cells results in a suppression of Aldara-induced inflammation. In vitro, IMQ induces the proliferation and IL-10 expression by B cells that is blocked by BCR signals inducing NFATc1. By binding to HDAC1, a transcriptional repressor, and to an intronic site of the Il10 gene, NFATc1 suppresses IL-10 expression that dampens the production of tumour necrosis factor-α and IL-17 by T cells. These data indicate a close link between NFATc1 and IL-10 expression in B cells and suggest NFATc1 and, in particular, its inducible short isoform, NFATc1/αA, as a potential target to treat human psoriasis.
Livin/BIRC7 is a member of the inhibitors of apoptosis proteins family, which are involved in tumor development through the inhibition of caspases. Aim was to investigate the expression of livin and other members of its pathway in adrenocortical tumors and in the adrenocortical carcinoma (ACC) cell line NCI-H295R.
The mRNA expression of livin, its isoforms α and β, XIAP, CASP3 and DIABLO was evaluated by qRT-PCR in 82 fresh-frozen adrenal tissues (34 ACC, 25 adenomas = ACA, 23 normal adrenal glands = NAG). Livin protein expression was assessed by immunohistochemistry in 270 paraffin-embedded tissues (192 ACC, 58 ACA, 20 NAG). Livin, CASP3 and cleaved caspase-3 were evaluated in NCI-H295R after induction of livin overexpression.
Relative livin mRNA expression was significantly higher in ACC than in ACA and NAG (0.060 ± 0.116 vs 0.004 ± 0.014 and 0.002 ± 0.009, respectively, p < 0.01), being consistently higher in tumors than in adjacent NAG and isoform β more expressed than α. No significant differences in CASP3, XIAP and DIABLO levels were found among these groups. In immunohistochemistry, livin was localized in both cytoplasm and nuclei. The ratio between cytoplasmic and nuclear staining was significantly higher in ACC (1.51 ± 0.66) than in ACA (0.80 ± 0.35) and NAG (0.88 ± 0.27; p < 0.0001). No significant correlations were observed between livin expression and histopathological parameters or clinical outcome. In NCI-H295R cells, the livin overexpression slightly reduced the activation of CASP3, but did not correlate with cell viability.
In conclusion, livin is specifically over-expressed in ACC, suggesting that it might be involved in adrenocortical tumorigenesis and represent a new molecular marker of malignancy.
Animal models are important tools to investigate the pathogenesis and develop treatment strategies for breast cancer in humans. In this study, we developed a new three-dimensional in vivo arteriovenous loop model of human breast cancer with the aid of biodegradable materials, including fibrin, alginate, and polycaprolactone. We examined the in vivo effects of various matrices on the growth of breast cancer cells by imaging and immunohistochemistry evaluation. Our findings clearly demonstrate that vascularized breast cancer microtissues could be engineered and recapitulate the in vivo situation and tumor-stromal interaction within an isolated environment in an in vivo organism. Alginate–fibrin hybrid matrices were considered as a highly powerful material for breast tumor engineering based on its stability and biocompatibility. We propose that the novel tumor model may not only serve as an invaluable platform for analyzing and understanding the molecular mechanisms and pattern of oncologic diseases, but also be tailored for individual therapy via transplantation of breast cancer patient-derived tumors.
BLIMP1 ist ein Transkriptionsfaktor und Schlüsselregulator in der Plasmazell-Differenzierung. Um die Rolle des BLIMP1 in der Lymphomentstehung zu untersuchen, wurde die BLIMP1 Expression im normalen humanen lymphatischen Gewebe und in 78 diffusen großzelligen B-Zell Lymphomen untersucht. BLIMP1 wurde in Plasmazellen und GC B-Zellen sowie in einer Population extrafollikulärer B-Zellen exprimiert. Die reifen Plasmazellen vom Marschalko-Typ waren CD138+CD20-MUM1+Ki67-BCL6-PAX5-BLIMP1+. Außerdem zeigten die Keimzentrums-B-Zellen keine Ki67-Expression. Im Gegensatz hierzu waren die BLIMP1+ EGBZ Ki67+p27-. BLIMP1 wurde in 19% (15/78) der DLBCL Fälle, darunter ABC- (7/15) und GCB- (8/15) Typ, exprimiert. BLIMP1+ DLBCL konnten entsprechend dem BLIMP1, BCL6 und PAX5 Expressionsprofil in drei pathogenetisch unterschiedliche Typen unterteilt werden. In den Typ A-Fällen waren die BLIMP1+ Tumor- zellen ständig BCL6-/PAX5- und waren alle vom ABC-Typ (CD10-/BCL6-/MUM1+). Im Typ B-DLBCL waren die meisten Tumorzellen ständig BLIMP1-/BCL6+/PAX5+ und BLIMP1 war nur in relativ kleinen Arealen herdförmig exprimiert. Die BLIMP1+ Zellen zeigten keine BCL6 und PAX5 Expression, und alle Typ B-Fälle zeigten ein GCB-Profil (CD10+ oder BCL6+ und MUM1-). Die Typ C-Fälle waren durch eine gleichzeitige BLIMP1 und BCL6 und/oder PAX5 Expression gekennzeichnet, was einem abärranten und nicht in normalen B-Zellen auftretenden Immunphänotyp entspricht. Weiterhin wurden in 7 Fällen mit Allelverluste auf der Genomregion 6q21, der das BLIMP1 Gen enthält, keine BLIMP1 Mutationen gefunden. Hinsichtlich einer BLIMP1 Expression im normalen lymphatischen Gewebe konnte festgestellt werden, dass das BLIMP1 nicht nur während der Plasmazellentwicklung aus den Keimzentrums-B-Zellen eine bedeutende Rolle spielt, sondern auch mit der Plasmazell-Differenzierung außerhalb des Keimzentrums assoziiert ist. Eine BLIMP1 Expression in DLBCL kennzeichnet die Fälle mit einer Plasmazell-Differenzierung. BLIMP1 ist in den Lymphomen größtenteils wie in normalen B-Zellen reguliert und besitzt die Kapazität, die Plasmazell-Entwicklung in die Tumorzellen zu induzieren. Jedoch reicht die BLIMP1 Expression weder aus, den Zellzyklus aufzuhalten, noch eine komplette terminale Plasmazell-Reifung in den DLBCL zu leiten. Allerdings scheint BLIMP1 nicht von den bekannten TSG Inaktivierungsmechanismen in den DLBCL betroffen zu sein, wobei es sehr unwahrscheinlich ist, dass das BLIMP1 ein TSG darstellt, dessen Verlust bei der Lymphomentwicklung eine wesentliche Rolle spielt.
Diabetes Mellitus Is a Possible Risk Factor for Nodo-paranodopathy With Antiparanodal Autoantibodies
(2022)
Background and Objectives
Nodo-paranodopathies are peripheral neuropathies with dysfunction of the node of Ranvier. Affected patients who are seropositive for antibodies against adhesion molecules like contactin-1 and neurofascin show distinct clinical features and a disruption of the paranodal complex. An axoglial dysjunction is also a characteristic finding of diabetic neuropathy. Here, we aim to investigate a possible association of antibody-mediated nodo-paranodopathy and diabetes mellitus (DM).
Methods
We retrospectively analyzed clinical data of 227 patients with chronic inflammatory demyelinating polyradiculoneuropathy and Guillain-Barré syndrome from multiple centers in Germany who had undergone diagnostic testing for antiparanodal antibodies targeting neurofascin-155, pan-neurofascin, contactin-1–associated protein 1, and contactin-1. To study possible direct pathogenic effects of antiparanodal antibodies, we performed immunofluorescence binding assays on human pancreatic tissue sections.
Results The frequency of DM was 33.3% in seropositive patients and thus higher compared with seronegative patients (14.1%, OR = 3.04, 95% CI = 1.31–6.80). The relative risk of DM in seropositive patients was 3.4-fold higher compared with the general German population. Seropositive patients with DM most frequently harbored anti–contactin-1 antibodies and had higher antibody titers than seropositive patients without DM. The diagnosis of DM preceded the onset of neuropathy in seropositive patients. No immunoreactivity of antiparanodal antibodies against pancreatic tissue was detected.
Discussion
We report an association of nodo-paranodopathy and DM. Our results suggest that DM may be a potential risk factor for predisposing to developing nodo-paranodopathy and argue against DM being induced by the autoantibodies. Our findings set the basis for further research investigating underlying immunopathogenetic connections.
Chromosomal translocations affecting the MYC oncogene are the biological hallmark of Burkitt lymphomas but also occur in a subset of other mature B-cell lymphomas. If accompanied by a chromosomal break targeting the BCL2 and/or BCL6 oncogene these MYC translocation-positive (MYC+) lymphomas are called double-hit lymphomas, otherwise the term single-hit lymphomas is applied. In order to characterize the biological features of these MYC+ lymphomas other than Burkitt lymphoma we explored, after exclusion of molecular Burkitt lymphoma as defined by gene expression profiling, the molecular, pathological and clinical aspects of 80 MYC-translocation-positive lymphomas (31 single-hit, 46 double-hit and 3 MYC+-lymphomas with unknown BCL6 status). Comparison of single-hit and double-hit lymphomas revealed no difference in MYC partner (IG/non-IG), genomic complexity, MYC expression or gene expression profile. Double-hit lymphomas more frequently showed a germinal center B-cell-like gene expression profile and had higher IGH and MYC mutation frequencies. Gene expression profiling revealed 130 differentially expressed genes between BCL6(+)/MYC+ and BCL2(+)/MYC+ double-hit lymphomas. BCL2(+)/MYC+ double-hit lymphomas more frequently showed a germinal center B-like gene expression profile. Analysis of all lymphomas according to MYC partner (IG/non-IG) revealed no substantial differences. In this series of lymphomas, in which immunochemotherapy was administered in only a minority of cases, single-hit and double-hit lymphomas had a similar poor outcome in contrast to the outcome of molecular Burkitt lymphoma and lymphomas without the MYC break. Our data suggest that, after excluding molecular Burkitt lymphoma and pediatric cases, MYC+ lymphomas are biologically quite homogeneous with single-hit and double-hit lymphomas as well as IG-MYC and non-IG-MYC+ lymphomas sharing various molecular characteristics.