Refine
Has Fulltext
- yes (526)
Is part of the Bibliography
- yes (526)
Year of publication
Document Type
- Journal article (311)
- Doctoral Thesis (214)
- Preprint (1)
Keywords
- multiple myeloma (38)
- Aspergillus fumigatus (34)
- Multiples Myelom (17)
- Plasmozytom (16)
- HIV (14)
- apoptosis (13)
- Dendritische Zelle (12)
- Aspergillus (11)
- T cells (10)
- cancer (10)
- Stammzelltransplantation (9)
- inflammation (9)
- Aspergillose (8)
- Immuntherapie (8)
- NAFLD (8)
- cytokines (8)
- Apoptosis (7)
- B cells (7)
- Diabetes mellitus (7)
- Dickdarmkrebs (7)
- Multiple myeloma (7)
- Therapeutisches Drug Monitoring (7)
- dendritic cells (7)
- stem cell transplantation (7)
- theranostics (7)
- Apoptose (6)
- COVID-19 (6)
- CXCR4 (6)
- Immunreaktion (6)
- Monoklonaler bispezifischer Antikörper (6)
- PET (6)
- T-Lymphozyt (6)
- allogeneic stem cell transplantation (6)
- immunotherapy (6)
- Akute myeloische Leukämie (5)
- Antigen CD40 (5)
- Dendritische Zellen (5)
- Hepatitis C (5)
- Immunsystem (5)
- Multiple Myeloma (5)
- NK cells (5)
- Natürliche Killerzelle (5)
- Positronen-Emissions-Tomografie (5)
- Real time quantitative PCR (5)
- Rezidiv (5)
- Rituximab (5)
- TNF (5)
- TRAIL (5)
- Therapie (5)
- aspergillosis (5)
- dendritic cell (5)
- immune response (5)
- infection (5)
- neuroendocrine tumor (5)
- relapse (5)
- therapeutic drug monitoring (5)
- AIDS (4)
- Adhärenz (4)
- Akute Leukämie (4)
- Antikörper (4)
- Candida albicans (4)
- Cytomegalie-Virus (4)
- Fettleber (4)
- Immunsuppression (4)
- Invasive Aspergillose (4)
- Medizin (4)
- Myelom (4)
- NASH (4)
- PRRT (4)
- Polymerase-Kettenreaktion (4)
- Proliferation (4)
- RNS-Interferenz (4)
- Rheumatoid arthritis (4)
- TDM (4)
- Transplantat-Wirt-Reaktion (4)
- allogene Stammzelltransplantation (4)
- aspergillus fumigatus (4)
- colorectal cancer (4)
- deep learning (4)
- fungal infection (4)
- galactomannan (4)
- innate immunity (4)
- invasive pulmonary aspergillosis (4)
- lenalidomide (4)
- lymphoma (4)
- medicine (4)
- prostate cancer (4)
- refractory (4)
- rheumatoid arthritis (4)
- stem-cell transplantation (4)
- survival (4)
- therapy (4)
- transplantation (4)
- Adenom-Karzinom-Sequenz (3)
- Allogeneic stem cell transplantation (3)
- B-Zell-Lymphom (3)
- B-Zelle (3)
- Bauchspeicheldrüse (3)
- Blutstammzelle (3)
- Bone marrow transplantation (3)
- Cytokine (3)
- Dasatinib (3)
- Depression (3)
- HIV-Infektion (3)
- Hochdosischemotherapie (3)
- Kolorektales Karzinom (3)
- Leberzellkrebs (3)
- Leberzirrhose (3)
- Lopinavir (3)
- Loss of heterozygosity (3)
- Monoklonaler Antikörper (3)
- Nachsorge (3)
- PCR (3)
- PET/CT (3)
- Pankreas (3)
- Periphere Stammzellentransplantation (3)
- RADS (3)
- RNA interference (3)
- Rheumatoide Arthritis (3)
- SARS-CoV-2 (3)
- SNP (3)
- SSTR (3)
- Survival (3)
- Südafrika (3)
- T cell (3)
- T-Zellen (3)
- T-cells (3)
- Tumor-Nekrose-Faktor <alpha> (3)
- Zelldifferenzierung (3)
- acute myeloid leukemia (3)
- adalimumab (3)
- adherence (3)
- anxiety (3)
- autologous stem cell transplantation (3)
- biomarker (3)
- butyrate (3)
- cancer immunotherapy (3)
- cell staining (3)
- chemotherapy (3)
- chimeric antigen receptor (3)
- colonoscopy (3)
- colorectal carcinoma (3)
- dendritische Zellen (3)
- depression (3)
- echocardiography (3)
- endoscopy (3)
- fatty liver disease (3)
- fear of progression (3)
- follow-up (3)
- immune cells (3)
- immunosuppression (3)
- insulin (3)
- invasive aspergillosis (3)
- machine learning (3)
- memory B cells (3)
- pancreas (3)
- plasma cells (3)
- prognosis (3)
- proliferation (3)
- quality of life (3)
- regression analysis (3)
- resistance (3)
- scleroderma (3)
- systemic sclerosis (3)
- toxicity (3)
- 18F-FDG PET/CT (2)
- 3D printing (2)
- AML (2)
- Activation (2)
- Acute myeloid leukemia (2)
- Adulte Stammzelle (2)
- Antibodies (2)
- Antigen (2)
- Antikörper-Fusionsproteine (2)
- Antimykotika (2)
- Antimykotikum (2)
- Arzneimittelüberwachung (2)
- Autogene Transplantation (2)
- Autologous hematopoietic stem cell transplantation (2)
- B cell (2)
- BCMA (2)
- BRAF mutation (2)
- Biomarker (2)
- Bone-marrow-transplantation (2)
- Butyrat (2)
- C-X-C motif chemokine receptor 4 (2)
- CA19-9 (2)
- CADe (2)
- CAR T cells (2)
- CCL4 (2)
- CD38 (2)
- CML (2)
- CMV (2)
- Cancer (2)
- Capecitabin (2)
- Chemotherapie (2)
- Chimerism (2)
- Chimärismus (2)
- Chronisch-myeloische Leukämie (2)
- Clostridium-difficile-Infektion (2)
- Colonkrebs (2)
- Colorectal Cancer (2)
- Compliance (2)
- Diabetes (2)
- Efavirenz (2)
- Expression (2)
- FDG (2)
- FIB-4 (2)
- GVHD (2)
- German Hepatitis C-Registry (2)
- Granulozyt (2)
- GvHD (2)
- HBV (2)
- HDGF (2)
- Helicobacter pylori (2)
- Hemibodies (2)
- Hepatitis B (2)
- Hepatozelluläres Karzinom (2)
- Hyperglykämie (2)
- Hypoxie (2)
- Hämostase (2)
- Imatinib (2)
- Immun-Checkpoint (2)
- Immunglobuline (2)
- Immunmodulation (2)
- Immunologie (2)
- Immunology (2)
- Immunsuppressiva (2)
- Infektiologie (2)
- Inflammasom (2)
- Inflammation (2)
- Insulin (2)
- Interleukin 8 (2)
- Kinder (2)
- Knochenmark (2)
- Kolonkarzinom (2)
- Kreuzreaktion (2)
- LL-37 (2)
- LOH (2)
- Lebensqualität (2)
- Lenalidomid (2)
- Leptin (2)
- Lipodystrophie (2)
- Lymphom (2)
- MUST-Score (2)
- Mangelernährung (2)
- Mucorales (2)
- NLRP3 (2)
- Nestin (2)
- Non-Hodgkin-Lymphom (2)
- Oncology (2)
- PD-L1 (2)
- Progredienzangst (2)
- Protein-Tyrosin-Kinasen (2)
- Psychoneuroimmunologie (2)
- Punktmutation (2)
- Pyrimidin-Synthese (2)
- RT-PCR (2)
- Real-time PCR (2)
- Rectal cancer (2)
- Resistenz (2)
- Ribavirin (2)
- Ruxolitinib (2)
- Schwangerschaft (2)
- Signalkette (2)
- Signaltransduktion (2)
- Stammzelle (2)
- Surgery (2)
- Systemic sclerosis (2)
- TRAF1 (2)
- TRAF2 (2)
- Th17 (2)
- Therapietreue (2)
- Thrombozyt (2)
- Transfektion (2)
- Transkription (2)
- Tumor-necrosis-factor (2)
- Uridin (2)
- Vitamin D (2)
- Wnt (2)
- YB-1 (2)
- [68Ga]PentixaFor (2)
- actin (2)
- activation (2)
- acute leukemia (2)
- acute lymphoblastic leukemia (2)
- acute myeloid leukaemia (2)
- adaptive immunity (2)
- adiponectin (2)
- adverse events (2)
- allogeneic hematopoietic stem cell transplantation (2)
- alloreactive T cells (2)
- amplicon sequencing (2)
- amyloidosis (2)
- anastomotic leakage (2)
- anemia (2)
- angeborenes Immunsystem (2)
- antibody (2)
- antimikrobielle Peptide (2)
- antirheumatic agents (2)
- artificial intelligence (2)
- autoimmunity (2)
- autologe Stammzelltransplantation (2)
- automation (2)
- beta-D-glucan (2)
- biomarkers (2)
- bone marrow (2)
- bone marrow immune-microenvironment (2)
- bortezomib (2)
- cancer stem cells (2)
- cell death (2)
- chemokines (2)
- cholestasis (2)
- chronic hepatitis C (2)
- chronic myelogenous leukemia (2)
- corticosteroids (2)
- cytotoxic T cells (2)
- cytotoxicity (2)
- daratumumab (2)
- dasatinib (2)
- deformation (2)
- diabetes mellitus (2)
- differentiation (2)
- ejection fraction (2)
- endoluminal (2)
- endoradiotherapy (2)
- endothelial cells (2)
- extramedullary disease (2)
- fatigue (2)
- fibrosis (2)
- fluorescence imaging (2)
- fungal infections (2)
- gastroenterology (2)
- gastrointestinale Tumore (2)
- gemcitabine (2)
- gene (2)
- gene expression (2)
- gene regulation (2)
- giant cell arteritis (2)
- graft versus host disease (2)
- hematologic malignancies (2)
- hematopoietic stem cell transplantation (2)
- hepatitis C virus (2)
- high risk (2)
- human dendritic cells (2)
- ileocecal resection (2)
- immunoassay (2)
- infectious diseases (2)
- innate immune response (2)
- interferon (2)
- invasive fungal infection (2)
- invasive fungal infections (2)
- kolorektales Karzinom (2)
- leukemia (2)
- loss of heterozygosity (2)
- management (2)
- metabolism (2)
- mitochondrial toxicity (2)
- molecular imaging (2)
- mortality (2)
- mouse model (2)
- mouse models (2)
- multiples Myelom (2)
- murine model (2)
- mycophenolic acid (2)
- myeloma (2)
- nab-paclitaxel (2)
- natural killer cells (2)
- negative pressure (2)
- obesity (2)
- object detection (2)
- oncology (2)
- organoids (2)
- oxidative stress (2)
- pancreatic cancer (2)
- peptide receptor radionuclide therapy (2)
- pharmacokinetics (2)
- phosphorylation (2)
- pomalidomide (2)
- posaconazole (2)
- psychological distress (2)
- real world evidence (2)
- real-time PCR (2)
- regulatory T cells (2)
- risk factors (2)
- risk stratification (2)
- signal transduction (2)
- sofosbuvir (2)
- somatostatin receptor (2)
- spleen (2)
- stem cells (2)
- surgical therapy (2)
- transfection (2)
- treatment outcome (2)
- vacuum-assisted closure (2)
- Überleben (2)
- /immunofluorescence (1)
- 11C-Methionine PET/CT (1)
- 13C-Methacetin-Atemtest (1)
- 177Lu (1)
- 18FDG-PET/CT (1)
- 18q21.1 (1)
- 2,5-diketopiperazines (1)
- 25-hydroxycholesterol 7 alpha-hydroxylase (1)
- 27.9c (1)
- 2p16.3 (1)
- 3 dimensional cell culture model (1)
- 3 fucosyltransferase-VI (1)
- 3D culture (1)
- 4-1BB Agonist (1)
- 4-1BB agonist (1)
- 41BBL (1)
- 5-Fluorouracil (1)
- 5q22.2 (1)
- 68Ga-DOTANOC (1)
- 68Ga-DOTATATE (1)
- 68Ga-DOTATATE/-TOC (1)
- 68Ga-DOTATOC (1)
- 68Ga-Pentixafor PET/CT (1)
- 8p22 (1)
- A. fumigatus (1)
- ABCG2 (1)
- ABL gene (1)
- AIM2 (1)
- AKT-signaling (1)
- ALiOS (1)
- AMPK (1)
- APRI (1)
- ARMS-PCR (1)
- ARONJ (1)
- ASE formula (1)
- ATIP (1)
- ATPase activity (1)
- ATTRv amyloidosis (1)
- AZT (1)
- Active disease (1)
- Acute lymphoblastic leukemia (1)
- Acute lymphocytic leukaemia (1)
- Acute myeloid leukemia (AML) (1)
- Adaptive cell transfer (1)
- Adenom-carcinom-sequence (1)
- Adhesive Hydrogels (1)
- Adiponectin (1)
- Adipositas (1)
- Adoptiver T Zell Transfer (1)
- Aiolos (1)
- Akt (1)
- Aktin (1)
- Alcoholic and Non-Alcoholic Steatohepatitis (1)
- Alkoholische Fettlebererkrankung (1)
- Allelische Verlustanalyse (1)
- Allergie (1)
- Allergiker (1)
- Alloantigen (1)
- Alloantigen Expression (1)
- Allogene Stammzelltransplantation (1)
- Allogene hämatopoetische Stammzelltransplantation (1)
- Allogeneic transplantation (1)
- Alpelisib (1)
- Alpha therapy (1)
- Alpha-dependent apoptosis (1)
- Aluminiumhydroxid (1)
- Aluminiumhydroxide (1)
- Ambulante Behandlung (1)
- Ambulante Patienten (1)
- Aminobisphosphonate (1)
- Amphibia (1)
- Amyloidose (1)
- Anthropometrie (1)
- Antibiotic stewardship (1)
- Antibiotikatherapie (1)
- Antibody (1)
- Antifungal (1)
- Antigen CD137 (1)
- Antigen CD19 (1)
- Antigen CD95 (1)
- Antigene (1)
- Antigenpräsentation (1)
- Antikörpertherapie (1)
- Antimikrobielle Peptide (1)
- Antiretrovirale Substanz (1)
- Antituberkulotikum (1)
- Antitumorforschung (1)
- Antrhopometry (1)
- Anämie (1)
- Aortenkonstriktion (1)
- Arteriosklerose (1)
- Arthroleptis amphibia (1)
- Arthrose (1)
- Arzneimittelnebenwirkung (1)
- Arzneimittelsicherheit (1)
- Arzneimittel�berwachung (1)
- Ascaris lumbricoides (1)
- Aspergillosis (1)
- Aspergillus fumigatus antigens (1)
- Aspergillus fumigatus-spezifische CD154+/CD4+ Zellen (1)
- Aspergillus sp. (1)
- Autoimmune diseases (1)
- Autoimmunität (1)
- Autoimmuntherapie (1)
- B cell culture (1)
- B cell receptors (1)
- B- Zellen (1)
- B-NHL (1)
- B-Zellen (1)
- B-cell lymphoma (1)
- B-cells (1)
- B-zellen (1)
- BAFF-Receptor (1)
- BAFF-Rezeptor (1)
- BAL (1)
- BCOR (1)
- BCORL1 (1)
- BFU (1)
- BH3-only proteins (1)
- BON-1 (1)
- BONJ (1)
- Bacteria (1)
- Baff (1)
- Bariatrische Operation (1)
- Barrett (1)
- Bauchspeicheldrüsenkrebs (1)
- Benzodiazepine (1)
- Beta-Zellen (1)
- Beta-cell (1)
- Betazelle (1)
- Bewältigungsfähigkeiten (1)
- Biologika (1)
- Bioluminescence (1)
- Bioluminescence imaging (1)
- Biolumineszenzmessung (1)
- Biomechanics (1)
- Biotechnologie (1)
- Bispecific T-cell engager (1)
- Blood (1)
- Blutkontakt (1)
- Blutspiegel (1)
- Blutstillung (1)
- Blutuntersuchung (1)
- Bone marrow cells (1)
- Bone marrow transplantantation (1)
- Breath tests (1)
- Brustkrebs (1)
- Bruton's tyrosine kinase inhibitor CC-292 (1)
- Butyrate <Buttersäuresalze> (1)
- Bypassoperation (1)
- C-IAP1 (1)
- C-Typ Lektin Rezeptoren (1)
- C1q/TNF related protein (CTRP) (1)
- C57BL/KALWRIJ mouse (1)
- CACO-2 (1)
- CAPA (1)
- CAR T (1)
- CAR T cell (1)
- CAR T-cell (1)
- CAR-T-cell (1)
- CASPASE-3 (1)
- CCL3 (1)
- CCL5 (1)
- CCN1 (1)
- CCS (1)
- CD 40 (1)
- CD11b+ myeloid cells (1)
- CD1c⁺ mDC (1)
- CD1d (1)
- CD20 (1)
- CD27 (1)
- CD274 (1)
- CD27L (1)
- CD319 (1)
- CD4(+) (1)
- CD4(+) T-cells (1)
- CD40 (1)
- CD40 agonist (1)
- CD40-spezifische Antikörperfusionsproteine (1)
- CD40L (1)
- CD57 (1)
- CD70 (1)
- CD95 (1)
- CDI (1)
- CFU (1)
- CIAP1 (1)
- CMR (1)
- CMV T-Zellen (1)
- CMV reactivation (1)
- CMV-Reaktivierung (1)
- CMV-specific cellular immunity (1)
- CNS cancer (1)
- COX2 expression (1)
- CP-690,550 (1)
- CRISPR/Cas9 (1)
- CS1 (1)
- CXCL10 (1)
- CYP2C9 (1)
- CYP3A4 (1)
- CYP7A1 (1)
- Calcitriol (1)
- Cancer genetics (1)
- Cancer risk factors (1)
- Cancer treatment (1)
- Candida sp. (1)
- Capicua transcriptional repressor (1)
- Cardiac Output (1)
- Cartiage Integration (1)
- Cartilage defect (1)
- Casetrain (1)
- Caspase-8 activation (1)
- Cathelicidin (1)
- Cathelicidine (1)
- Cell migration (1)
- Central nervous system (1)
- Central nervous system infection (1)
- Checkpoint-Inhibitor (1)
- Chimäre DNS (1)
- Chimärische Rezeptoren (1)
- Chimärismusdiagnostik (1)
- Cholesterinstoffwechsel (1)
- Chromosom 8 (1)
- Chromosomenanalyse (1)
- Chronic lymphoblastic leukemia (1)
- Chronic myeloid leukaemia (1)
- Chronic myeloid leukemia (1)
- Ciliary beat frequency (1)
- Clinical practice guidelines (1)
- Clinical remission (1)
- Colitis ulcerosa (1)
- Complex (1)
- Compliance <Patient> (1)
- Computerunterstütztes Lernen (1)
- Conditioning regimen (1)
- Copy number changes (1)
- Coronavirus Disease 2019 (1)
- Crohn-Krankheit (1)
- Crohn’s Disease (1)
- Crohn’s disease (1)
- Cytokine receptors (1)
- Cytomegalie (1)
- Cytoplasma (1)
- Cytotoxizität (1)
- D insufficiency (1)
- D serum-levels (1)
- D2S123 (1)
- D5S346 (1)
- DAS28 (1)
- DC (1)
- DExD/H-Box RNA helicase (1)
- DMARD (1)
- DNA damage (1)
- DOTATOC (1)
- DSMM XIV (1)
- DSMMI-Studie (1)
- Dara-KDT-P(A)CE (1)
- Darm (1)
- Darmepithel (1)
- Darminfektion (1)
- Dectin-1 (1)
- Depressivität (1)
- Deutsche Gesellschaft für Hämatologie und Onkologie. Arbeitsgemeinschaft Infektiologie (1)
- Deutsche Gesellschaft für Rheumatologie (1)
- Diabetes mellitus Typ 2 (1)
- Diagnosis (1)
- Diagnostik (1)
- Dihydroorotat-Dehydrogenase (1)
- Distress (1)
- Donor lymphocytes (1)
- Dopamine (1)
- Drug Monitoring (1)
- Drug development (1)
- Drug metabolism (1)
- Drug resistance (1)
- Drug-free remission (1)
- Duchenne muscular dystrophy (1)
- Durchflusscytometrie (1)
- Durchflusszytometrie (1)
- E-Selectin (1)
- E2F3 (1)
- EAE (1)
- EFV (1)
- EGFR (1)
- ELISA (1)
- ELISpot (1)
- EORTC (1)
- ERM (1)
- Effektorfunktionen (1)
- Einfluss (1)
- Einflussfaktoren (1)
- Einstellung zum Tod (1)
- Eisenhomöostase (1)
- Elderly (1)
- Elektroporation (1)
- Emotionsregulierung (1)
- Encephalopathia hepatica (1)
- EndoVAC and small bowel (1)
- Endocytose (1)
- Endozytose (1)
- Enterale Ernährung (1)
- Entwicklung (1)
- Enzyme Regulation (1)
- EpCAM (1)
- Epstein-Barr virus-induced gene 2 (1)
- Ernährungsberatung (1)
- Escherichia Coli (1)
- European experience (1)
- European experts (1)
- European group (1)
- Everolimus (1)
- Expansion (1)
- Extraktionskontrolle (1)
- Extramedullary disease (1)
- FAP (1)
- FDG-PET/CT (1)
- FGF19 (1)
- FOLFIRI (1)
- FOLFOX (1)
- FP635 (1)
- FXR (1)
- Factor receptor (1)
- Fahrradergometer (1)
- Fak regulation (1)
- Fas-Ligand (1)
- Fas-Signalweg (1)
- FcgR (1)
- Fettsucht (1)
- Fettsäurestoffwechsel (1)
- Fibroblast activator protein I (1)
- Fibroblastenwachstumsfaktor (1)
- Fick principle (1)
- Fick-Prinzip (1)
- Fieber (1)
- Fludarabine (1)
- Fludarabine-treosulfan (FT) (1)
- Fluoreszenzakti (1)
- Fluoreszenzmikroskopie (1)
- Fluoreszenzproteine (1)
- Follow-up (1)
- Fractalkin (1)
- Fructose (1)
- Fruktose (1)
- Fungal (1)
- Funktionelle Validierung (1)
- Fusarium (1)
- Fusionsprotein (1)
- GCA (1)
- GDF (1)
- GDF 15 (1)
- GDF-15 (1)
- GEP-NET (1)
- GI (1)
- GITRL (1)
- GLP-1 (1)
- GRAID (1)
- GSK3 (1)
- GUT-directed hypnotherapy (1)
- GVL (1)
- Gammadelta T Zellen (1)
- Ganzkörperbestrahlung (1)
- Gastrointestinal (1)
- Geki (1)
- Gelenkknorpel (1)
- Gelenkrheumatismus (1)
- Generalisierte Angststörung (1)
- Genetics research (1)
- Genexpression (1)
- Genklonierung (1)
- Gentechnologie (1)
- Geschlechtsunterschied (1)
- Gesundheitsförderung (1)
- Glucose (1)
- Glucose metabolism (1)
- Glutamat-Decarboxylase (1)
- Glutamate-induced excitotoxicity (1)
- Glycoproteinfucosyltransferasen (1)
- Glykoproteine (1)
- Glykämischer Index (1)
- Graft versus Host Disease (1)
- Graft versus Host disease (1)
- Graft versus Leukemia (1)
- Graft versus Tumor (1)
- Graft-versus-Host-Disease (1)
- Graft-versus-Leukämie-Effekt (1)
- Graft-versus-host disease (1)
- Graft-versus-host-disease (1)
- Graft-versus-leukemia (1)
- Grave’s disease (1)
- Growth-differentiation Factor 15 (1)
- Gruppo-italiano (1)
- Guideline (1)
- Guinea pig model (1)
- Guinean rain forest (1)
- GvL Effekt (1)
- HAART (1)
- HADS-D (1)
- HAQ (1)
- HB-EGF (1)
- HCV (1)
- HCV cure (1)
- HCV genotype 2 (1)
- HCV genotype-2 (1)
- HCV infection (1)
- HD (1)
- HDAC-Inhibitor (1)
- HECT Ligase (1)
- HEV (1)
- HGF (1)
- HIF-1α (1)
- HIV infections (1)
- HIV therapy (1)
- HIV-1-infected subjects (1)
- HIV-infected patients (1)
- HLA antigens (1)
- HLA-E matching (1)
- HNSCC (1)
- HPLC (1)
- HSC (1)
- HSF1 (1)
- HST1 (1)
- HSTC outcome (1)
- HT29 cells (1)
- HUWE1 (1)
- Haematology (1)
- Haploidentical (1)
- Hashimoto Thyreoiditis (1)
- Hashimoto-Thyreoiditis (1)
- Haut (1)
- Hautmodell (1)
- Heavy Light Chain Assay (1)
- Helicobacter (1)
- Helicobacter pylori eradication (1)
- Helicobacter-pylori-Eradikation (1)
- Hematopoietic Cell Transplantation (1)
- Hematopoietic stem cell transplantation (1)
- Hemibody (1)
- Hepatische Enzephalopathie (1)
- Hepatitis (1)
- Hepatitis B virus (1)
- Hepatitis B virus reactivation (1)
- Hepatitis C infection (1)
- Hepatitis E (1)
- Hepatitis-C-Virus (1)
- Hepatoma Derived Growth Factor (1)
- Hepatoma-derived Growth Factor (1)
- Hepatoma-derived growth factor (1)
- Hepatotoxizität (1)
- Hepatozelluläres Karzinom HCC (1)
- Herpes simplex encephalitis (1)
- Herpes simplex virus (1)
- Herz-Lungen-Maschine (1)
- Herzinsuffizienz (1)
- Herzzeitvolumen (1)
- High Performance Liquid Chromatography (1)
- Hippo signaling (1)
- Histon-Deacetylase (1)
- Hitzeschock Proteine (1)
- Hitzeschocktranskriptionsfaktor (1)
- Homing-Rezeptor (1)
- Homingrezeptor (1)
- Hospitalismus <Hygiene> (1)
- Hsp90 (1)
- Human immunodefiency virus (1)
- Humanserum (1)
- Hyaliner Knorpel (1)
- Hypercholesterinämie (1)
- Hyperglycemia (1)
- Hypersensitivität (1)
- Hypersensitivitätsreaktion (1)
- Hyperthermie (1)
- Hypertriglyzeridämie (1)
- Hämatopoetische Stammzelltransplantation (1)
- IDO-1 (1)
- IDX-1 (1)
- IE1 (1)
- IFN-gamma (1)
- IFN-γ ELISpot (1)
- IFNG (1)
- IKK (1)
- IKZF1 (1)
- IKZF3 (1)
- IL 10 (1)
- IL 12 (1)
- IL 12p40 (1)
- IL-12 family (1)
- IL28B (1)
- IL28B polymorphisms (1)
- IL8 (1)
- IRF4 (1)
- Ikaros (1)
- Immunantwort (1)
- Immunassay (1)
- Immuncheckpointblockade (1)
- Immuncheckpointinhibition (1)
- Immuncheckpointinhibitor (1)
- Immune cell assays (1)
- Immune receptor signaling (1)
- Immunfluoreszenz (1)
- Immunoassay (1)
- Immunoblot (1)
- Immunocompromised patient (1)
- Immunoglobulins (1)
- Immunosuppressant (1)
- Immunotherapie (1)
- Immunotherapy (1)
- Immunreaction (1)
- Immunrekonstitution (1)
- Immunstimulation (1)
- Immunzellassays (1)
- Impfstoff (1)
- Impfung (1)
- Impfvektor (1)
- Improved survival (1)
- Induced apoptosis (1)
- Infections (1)
- Infectious Diseases (1)
- Infectious complications (1)
- Infectious disease (1)
- Infectious diseases (1)
- Infektion (1)
- Influenzae type B (1)
- Integrin aV (1)
- Interaktionsanalyse (1)
- Interferon <gamma-> (1)
- Interferon alpha (1)
- Interleukin 13 (1)
- Interleukin 1beta (1)
- Interleukin 2 (1)
- Interleukin 4 (1)
- Interleukin 5 (1)
- Interleukin 6 (1)
- Interleukin-10 (1)
- Interleukin-2 (1)
- Interleukin-5 (1)
- Intestamin® (1)
- Intracellular domain (1)
- Invasive Aspergillosis (1)
- Invasive Mykosen (1)
- Invasive Mykosen bei immunsupprimierten Patienten (1)
- Invasive aspergillosis (1)
- Invasive fungal-infections (1)
- Isolation (1)
- JAK2 (1)
- JCV (1)
- JNK (1)
- Jak kinases (1)
- K+-ATPase (1)
- K-ras (1)
- KAR (1)
- KIR (1)
- KRAS (1)
- KRas (1)
- Kappa-B activation (1)
- Kappa-B pathway (1)
- Kartierung (1)
- Kernpore (1)
- Kernproteine (1)
- Kerntransport (1)
- Kieferosteonekrose (1)
- Killer cell immunoglobulin-like receptors (1)
- Kinderheilkunde (1)
- Klonale T-Zellen (1)
- Klonierung (1)
- Kniegelenkarthrose (1)
- Knochemark (1)
- Knochenmark-Mikromilieu (1)
- Knochenmarkbiopsie (1)
- Knochenmarktransplantation (1)
- Knockdown (1)
- Knorpel (1)
- Kognition bei mHE (1)
- Kohlenhydrate (1)
- Kohlenstoff-13-Exhalationstest (1)
- Kolon (1)
- Kono-S anastomosis (1)
- Kontamination (1)
- Kostimulation (1)
- Kreuzpräsentation (1)
- Kreuzreaktivität (1)
- Kulturmedium (1)
- Kursdesign (1)
- Körperarbeit (1)
- Körperflüssigkeit (1)
- Körperpsychotherapie (1)
- Körpertherapie (1)
- LATE DEATHS (1)
- LBH589 (1)
- LINE-1 retrotransposition (1)
- LL37 (1)
- LPS (1)
- Lactose (1)
- Langzeitaplasie (1)
- Late mortality (1)
- Ldlr-Knockout (1)
- Lebensqualität bei mHE (1)
- Lebererkrankung (1)
- Leberfunktion (1)
- Leberversagen (1)
- Leukaemia-inhibitory factor (1)
- Leukopenie (1)
- Li-Fraumeni syndrome (1)
- Lichtheimia (1)
- Ligand (1)
- Light Sheet Fluorescence Microscopy (1)
- Lipid metabolism (1)
- Lipidstoffwechsel (1)
- Lipoatrophie (1)
- Lipodystrophie-Syndrom (1)
- Lipodystrophy syndrom (1)
- Lipofektion (1)
- Liposomal amphotericin-B (1)
- Liver cirrhosis (1)
- Low-dose acyclovir (1)
- Lymphatische Leukämie (1)
- Lymphomas (1)
- Lymphome (1)
- Lysozym (1)
- M30 (1)
- MAG3 (1)
- MALT (1)
- MALT-Lymphom (1)
- MALT-Lymphoma (1)
- MAP-Kinase (1)
- MAPKAPK2 (1)
- MCL-1 (1)
- MDSC (1)
- MEDAS (1)
- MEK/ERK-signaling (1)
- MGUS (1)
- MHC (1)
- MHC molecules (1)
- MHC-Klasse-I-Peptidom (1)
- MI-RADS (1)
- MICA (1)
- MIP-1β (1)
- MOPC315.BM (1)
- MOR202 (1)
- MPACT (1)
- MRONJ (1)
- MS-18 (1)
- MSI (1)
- MSS (1)
- MTB (1)
- MTUS1 (1)
- MTX (1)
- MUD (1)
- MYC (1)
- Magenlymphom (1)
- Malabsorption (1)
- Malassimilation (1)
- Malignant melanoma (1)
- Malignes Lymphom (1)
- Malnutrition (1)
- Mammakarzinom (1)
- Masernvirus (1)
- Maus (1)
- Mausmodell (1)
- Mechanisms (1)
- Medication-related osteonecrosis of the jaw (1)
- Medicine (1)
- Medikamenten-assoziierte Kiefernekrose (1)
- Megakaryopoese (1)
- Megakaryozyt (1)
- Melanoma (1)
- Memory B cells (1)
- Merkmal (1)
- Mesenchymal stem cells (1)
- Met (1)
- Metabolisches Syndrom (1)
- Metastase (1)
- Methotrexate (1)
- Mevalonatmetabolimus (1)
- Microarray (1)
- Midollo-Osseo (1)
- Migration (1)
- Mikrobiom <Genetik> (1)
- Mikrosatellit (1)
- Mikrosatelliten (1)
- Mikrosatelliteninstabilität (1)
- Mikrosomale Leberfunktion (1)
- Milde Depression (1)
- Minimal residual disease (1)
- Minimale Resterkrankung (1)
- Minor histocompatibility antigen mismatch transplantation (1)
- Mitochondriale Toxizität (1)
- Modifiziertes Vaccinia Ankara Virus (1)
- Moesin (1)
- Molecular Biophysics (1)
- Molecularly targeted therapy (1)
- Molekularbiologie (1)
- Molekulare Diagnostik (1)
- Molekulargenetik (1)
- Mucormycosis (1)
- Multiple (1)
- Multiple Regression (1)
- Multiplex-PCR (1)
- Multivariate analysis (1)
- Myc (1)
- Mycobacterium avium (1)
- Mycophenolatmofetil (1)
- Myeloma (1)
- Myeloma cells (1)
- Myelomas (1)
- Myelose (1)
- Mykose (1)
- Mykosen (1)
- Myokardhypertrphie (1)
- NA (1)
- NADPH oxidase (1)
- NET (1)
- NF-Kappa B (1)
- NF-Kappa-B (1)
- NF-κB/NFAT reporter cells (1)
- NFAT (1)
- NFATc1 (1)
- NFKB (1)
- NFkB (1)
- NFkB-relatedgenes (1)
- NFkappaB (1)
- NGS (1)
- NK (1)
- NK cell (1)
- NK-DC cross-talk (1)
- NK-Zelle (1)
- NK-Zellen (1)
- NK-cells (1)
- NKT Zellen (1)
- NKT cells (1)
- NLRP3 Inflammasom (1)
- NRF2 (1)
- NRTI (1)
- NRTI-Sparing (1)
- Na+ (1)
- Nadelstichverletzungen (1)
- Nasenschleimhaut (1)
- Natürliche Killer-Zellen (1)
- Natürliche Killerzellen (1)
- Nebenwirkung (1)
- Nebenwirkungen interferonbasierte Hepatitis-C-Therapie (1)
- Necrosis (1)
- Neuroendocrine (1)
- Neuroendocrine Tumor (1)
- Neuroendokriner Tumor (1)
- Neuropsychiatrische Nebenwirkungen Interferon alpha (1)
- Neutropenie (1)
- Neutrophil granulocytes interaction (1)
- Neutrophile Granulozyten (1)
- Neutrophiler Granulozyt (1)
- Nevirapin (1)
- Nichtalkoholische Fettlebererkrankung (1)
- Nichtalkoholische Fettleberhepatitis (1)
- Nucleoporine (1)
- Nuklearfaktor Kappa B (1)
- Nup214 (1)
- Nutritional Counseling (1)
- OSM (1)
- OX40L (1)
- Oberflächenmarker (1)
- Occludin (1)
- Off-Pump (1)
- Oldenburg burnout inventory (1)
- Oligomerisation (1)
- Oncostatin M (1)
- Onkologie (1)
- Optimierung (1)
- Osmr-Knockout (1)
- Osteoklast (1)
- Osteoporose (1)
- Outpatients (1)
- P14ARF (1)
- P67(PHOX) (1)
- PEG (1)
- PEG-Anlage (1)
- PHQ-4 (1)
- PI (1)
- PML (1)
- PMR (1)
- POU6F2-AS2 (1)
- PPARgamma (1)
- PROMISE (1)
- PROM’s (1)
- PSMA (1)
- PSMA-RADS (1)
- PSMC2 (1)
- PTBS (1)
- PTSD (1)
- PU.1 (1)
- Panel-Sequenzierung (1)
- Pankreaskarzinom (1)
- Pankreaskarzinomzentrum (1)
- Parkinsons-disease (1)
- Pathogenesis (1)
- Patient Reported Outcome (1)
- Patientencompliance (1)
- Patientenversorgung (1)
- Petropedetidae (1)
- Peyer's patch (1)
- Pharmakokinetik (1)
- Phase- (1)
- Phrynobatrachus amphibia (1)
- Plasmaspiegel (1)
- Plasmazellinie (1)
- Plasmide (1)
- Pneumocystis-carinii-pneumonia (1)
- Poly (I:C) (1)
- Poly(I:C) (1)
- Polymerase chain raction (1)
- Polymorphismus (1)
- Pom‐PAD‐Dara (1)
- Posaconazol (1)
- Positron emission tomography (1)
- Poststationär (1)
- Posttraumatische Belastungsstörung (1)
- Prediction (1)
- Primärtherapie (1)
- Prodigy (1)
- Prognostic scoring system (1)
- Progressive multifocal leukoencephalopathy (1)
- Promyelozytenleukämie (1)
- Prospektive klinische Verlaufsstudie (1)
- Protein p8 (1)
- Prädiktiver Biomarker (1)
- Prävention (1)
- Pseudomonas aeruginosa (1)
- Psychischer Stress (1)
- Psychotherapie (1)
- Pyrimidine Synthesis (1)
- QGP-1 (1)
- QoL (1)
- Qualität (1)
- QuantiFERON\(^®\)-TB Gold Plus (1)
- Quercetin (1)
- R-CHOP (1)
- RAD (1)
- RAR (1)
- RIG-I (1)
- RIP1 (1)
- RNA (1)
- RNA Interferenz (1)
- RNA extraction (1)
- RNAi (1)
- RNS-Bindungsproteine (1)
- ROR1 (1)
- RT-qPCR (1)
- RXR (1)
- RYGB (1)
- Radiochemotherapy (1)
- Radionuclide Therapy (1)
- Radiotherapie (1)
- Radiotherapy (1)
- Ranidae (1)
- Reaktive Depression (1)
- Rebreathing (1)
- Recombinant protein (1)
- Regeneration (1)
- Regressionsanalyse (1)
- Regulatory-cells (1)
- Rekombinantes Protein (1)
- Resiquimod (1)
- Respiratory syncytial virus (1)
- Responses (1)
- Reverse Transkriptase (1)
- Reverse Transkriptase-Polymerase-Kettenreaktion (1)
- Reversed Phase-HPLC (1)
- Rezidivtherapie (1)
- Rheumapatient (1)
- Rheumatoid Arthritis (1)
- Rheumatoider arthritis (1)
- Rheumatologie (1)
- Rhizopus (1)
- Rhizopus arrhizus (1)
- Risikofaktoren (1)
- Risk factors (1)
- Rosen-Methode (1)
- Rückatmungssystem (1)
- S100A8/S100A9 (1)
- SF-12 (1)
- SKY (Spektrale Karyotypisierung) (1)
- SLAMF7 (1)
- SNP Array (1)
- SSTR-RADS (1)
- STAT1 (1)
- STAT3 (1)
- STAT3 activation (1)
- STS (1)
- SVR (1)
- Saccharomyces cerevisiae (1)
- ScFv (1)
- Schilddrüse (1)
- Schimmelpilzallergie (1)
- Schimmelpilze (1)
- Scleroderma (1)
- Score (1)
- Serumbiomarker (1)
- Serumkonzentrationen (1)
- Serumspiegelbestimmung (1)
- Severe Acute Respiratory Syndrome Coronavirus 2 (1)
- Sibling donor (MSD) (1)
- Signal transduction (1)
- Signaling (1)
- Signaling complex (1)
- Signalwegskaskaden (1)
- Simulationsprogramm (1)
- Single Nucleotid Polymorphismus IL28B (1)
- Single chain (1)
- Single nucleotide polymorphism (1)
- Single-chain TNF (1)
- Sjögren’s syndrome (1)
- Skin cancer screening (1)
- Sleeping Beauty (1)
- Small intestine (1)
- Societe Francaise (1)
- Solid Phase Extraction (1)
- Sorafenib (1)
- Spender-Chimärismus (1)
- Spendermerkmal (1)
- Spezifisch (1)
- Spleen (1)
- Splicing (1)
- Stabilisierung (1)
- Stage distribution (1)
- Stammzellen (1)
- Standardisierung (1)
- Stavudin (1)
- Stem cell transplantation (1)
- Stickstoffheterocyclen (1)
- Stimulating factor (1)
- Strahlentherapie (1)
- Strategies to Obtain Tumor-Reactive Cells (1)
- Stress-Kardiomyopathie (1)
- Stressreaktion (1)
- Stromal cells (1)
- Structural Biology (1)
- Sulfadiazin (1)
- Suppression (1)
- Survival analysis (1)
- Synovitis (1)
- Säuglinge (1)
- T Zelle (1)
- T Zellen (1)
- T cell rezeptor transfer (1)
- T-Helfer-Zellen (1)
- T-LGL-Leukämie (1)
- T-LGL-Zellen (1)
- T-Lymphozyten-Rezeptor (1)
- T-Track\(^®\) TB (1)
- T-Zell-Rezeptor Transfer (1)
- T-Zellrezeptor (1)
- T-cell (1)
- T-cell engager (1)
- T-cell transfer (1)
- TB (1)
- TCTP (1)
- TKI (1)
- TLR agonists (1)
- TME (1)
- TNF a (1)
- TNF receptor associated factor 2 (TRAF2) (1)
- TNF-related apoptosis-inducing ligand (1)
- TNFR2 (1)
- TNFR2-spezifische Agonisten (1)
- TNFRSF (1)
- TNFSF14 (1)
- TNFSF4 (1)
- TNM staging (1)
- TNRSF (1)
- TP53 (1)
- TPCA1 (1)
- TRAILR-Mutants (1)
- TSD (1)
- TSLP (1)
- TTR knockdown (1)
- TTR stabilization (1)
- TWEAK (1)
- Tansania (1)
- Tdp-43 (1)
- Teichholz formula (1)
- Th17 cells (1)
- Th9 (1)
- Therapeutic Drug Monitoring (1)
- Therapeutisches Drug monitoring (1)
- Therapieabbruch (1)
- Therapieerfolg (1)
- Therapieversagen (1)
- Therapy (1)
- Thiotepa-busulfan-fludarabine (TBF) (1)
- Thromboyztenregeneration (1)
- Tight junction (1)
- Time interval (1)
- Tissue Engineering (1)
- Toll-like Receptor (1)
- Toll-like-Rezeptoren (1)
- Toxoplasmose (1)
- Tracer (1)
- Trainingsprogramm (1)
- Transarterielle Chemoembolisation (1)
- Transcription (1)
- Transkriptionsfaktor (1)
- Translational research (1)
- Transplantation (1)
- Transport (1)
- Treatment (1)
- Tregs (1)
- Trimerisation (1)
- Troponin I (1)
- Trypanosoma (1)
- Tuberkulose (1)
- Tumor Immuntherapie (1)
- Tumor-Nekrose-Faktor (1)
- Tumor-Nekrose-Faktor <alpha-Inhibitor> (1)
- Tumorantigen (1)
- Tumorassoziierte Antigene (1)
- Tumorimmunologie (1)
- Tumornekrosefaktor Liganden Superfamilie (1)
- Tumornekrosefaktor Rezeptor Superfamilie (1)
- Tumorsuppressor-Gen (1)
- Tumorsuppressorgen (1)
- Tumosuppresorgen (1)
- Tutor-System (1)
- Typ I Interferon (1)
- Tyrosine phosphorylation (1)
- Ubiquitin (1)
- Umkehrphasen-HPLC (1)
- Uniparentale Disomie (1)
- Unrelated donor (UD) (1)
- Untertyp (1)
- Upper Guinea (1)
- Uridine (1)
- Urinalkalisierung (1)
- VCE (1)
- VLA-1 (1)
- Vaccinia-Virus (1)
- Validation (1)
- Varicella-Zoster-Virus (1)
- Varicella-zoster-virus (1)
- Verhalten und Verhaltensmechanismen (1)
- Versorgungsrealität (1)
- Verträglichkeit Interferon alpha (1)
- Vibrationplattsntraining (1)
- Videokapselendoskopie (1)
- Viral (1)
- Virologie (1)
- Vitamin A (1)
- Vitamin D3 (1)
- WBV (1)
- Wachstum (1)
- Wachstumsfaktoren (1)
- Waldeyer’s tonsillar ring (1)
- Web-based-Training (1)
- Wechselwirkungen (1)
- Western diet (1)
- Wilms tumor protein 1 (1)
- Wireless capsule- endoscopy (1)
- Wue-1 (1)
- X-Ray Chrystallography (1)
- YAP (1)
- ZM336372 (1)
- Zelladhäsion (1)
- Zelladhäsionsblockade (1)
- Zellkontakt (1)
- Zellkultur (1)
- Zelllysat (1)
- Zellmigration (1)
- Zidovudin (1)
- Zielzelle <Immunologie> (1)
- Zilienschlagfrequenz (1)
- Zink (1)
- Zuckeraustauschstoff (1)
- Zufriedenheit mit PEG (1)
- Zukunftsangst (1)
- Zytokin-induzierte Killerzellen (1)
- Zytokine (1)
- Zytotoxizität (1)
- [177Lu]/[90Y]PentixaTher (1)
- [177Lu]PentixaTher (1)
- [18F]FDG PET/CT (1)
- [90Y]PentixaTher (1)
- [\(^{68}\)Ga] Pentixafor (1)
- [\(^{68}\)Ga]Ga-FAPI (1)
- [\(^{68}\)Ga]Pentixafor (1)
- \(^{11}\)C-methionine (1)
- abnormalities (1)
- according to guidelines (1)
- acoustic radiation force impulse imaging (1)
- activating receptors (1)
- active TB (1)
- active antiretroviral therapy (1)
- acute Graft versus Host Disease (1)
- acute graft-versus host disease (1)
- acute graft-versus-host disease (1)
- acute hypobaric hypoxia (1)
- acute kidney injury (1)
- acute leukemia (AL) (1)
- acute lymphoblastic leukaemia (1)
- acute myelogenous leukemia (1)
- acute myeloic leukemia (1)
- acute myeloid-leukemia (1)
- acute respiratory distress syndrome (1)
- adaptive Immunantwort (1)
- adenocarcinoma of the ampulla of Vater (1)
- adenoma-carcinoma-sequence (1)
- adhesion (1)
- adhesion molecule (1)
- adjuvant (1)
- adoptive cell therapy (1)
- adoptive t cell transfer (1)
- adoptive transfer (1)
- adrenocortical carcinoma (1)
- adulte Stammzelle (1)
- adults (1)
- afatinib (1)
- africans (1)
- after-care (1)
- agar diffusion test (1)
- agonist (1)
- akute myeloische Leukämie (1)
- all-cause mortality (1)
- allelischer Verlust (1)
- allergic subjects (1)
- alloSCT patients (1)
- alpha1 (1)
- alternative to animal testing (1)
- alveolar epithelium (1)
- ambulant (1)
- ambulatory (1)
- amphotericin B (1)
- amsacrine (1)
- amyloid‐directed antibodies (1)
- amyotrophic lateral sclerosis (1)
- anaplastic medulloblastoma (1)
- anastomotic leak (1)
- androgen deprivation therapy (1)
- angeborene Immunabwehr (1)
- animal model (1)
- annotation (1)
- anti-hDEC205-WT1 antibody fusion protein (1)
- anti-infective vaccination (1)
- anti-proliferative effects (1)
- antibiotic therapy (1)
- anticoagulation (1)
- antifungal (1)
- antifungal agents (1)
- antifungals (1)
- antigen loss (1)
- antigen processing and presentation (1)
- antigens (1)
- antileukemia vaccine (1)
- antimicrobial peptide (1)
- antimicrobials (1)
- antimikrobial peptides (1)
- antiphospholipid syndrome (1)
- antiresorptive drug-related osteonecrosis of the jaw (1)
- antiretroviral therapy (1)
- antithrombotic therapy (1)
- antiviral treatment (1)
- aplastic anemia (1)
- april (1)
- arthritis (1)
- asymptomatic patients (1)
- asymptomatische Patienten (1)
- at-home sampling (1)
- atherosclerosis (1)
- atrial fibrillation (1)
- attitude to death (1)
- autoantibodies (1)
- autoimmune disease (1)
- autoimmune encephalitis (1)
- autologous (1)
- autologous hematopoietic stem cell transplantation (1)
- autologous transplantation (1)
- autologous tumor (1)
- autophagy (1)
- axi-cel (1)
- axonal transcriptome (1)
- bacterial infection (1)
- bcells (1)
- bcl-2 (1)
- behavior and behaviormechanisms (1)
- benzodiazepines (1)
- beta-Zellproliferation (1)
- beta-cell (1)
- beta-cells (1)
- beta-oxidation (1)
- bile (1)
- biliary-tract cancer (1)
- binding (1)
- biodiversity (1)
- biodiversity hotspot (1)
- biofilm formation (1)
- biological fluorescence (1)
- bioluminescence imaging (1)
- biomarkers Myelomas (1)
- biophosphonate (1)
- biophysics (1)
- biopsy (1)
- biosynthesis (1)
- bispecific (1)
- bispecific antobodies (1)
- bispezifisch (1)
- blast cell lysate (1)
- blast-derived RNA (1)
- blinatumomab (1)
- blinatumoman (1)
- blood (1)
- blood count (1)
- blood flow (1)
- bone (1)
- bone adaptation (1)
- bone disease (1)
- bone imaging (1)
- bone marrow angiogenesis (1)
- bone marrow cells (1)
- bone marrow exam (1)
- bone marrow failure (1)
- bone marrow homing (1)
- bone marrow micro-environment (1)
- bone marrow transplantation (1)
- bone-disease (1)
- bone-mineral density (1)
- bortezomib plus dxamethasone (1)
- brain tumor (1)
- breakpoint (1)
- breakthrough infection (1)
- breast cancer (1)
- bridge-to-transplant (1)
- bridging (1)
- bromohydrin pyrophosphat (1)
- bromohydrin pyrophosphate (1)
- bronchoalveolar lavage fluid (1)
- burnout (1)
- bypassoperation (1)
- c-ART (1)
- c-ART Kinder (1)
- c-Jun N-terminal kinase (1)
- c-Jun N-terminale Kinase (1)
- c-reactive protein (1)
- cIAP (1)
- calcium imaging (1)
- calcofluor white staining (1)
- calprotectin (1)
- cancer care (1)
- cancer metabolism (1)
- cancer of unknown primary (CUP) (1)
- cancer predisposition (1)
- cancer prevention (1)
- cancer treatment (1)
- cancer vaccines (1)
- cancer-induced bone disease (1)
- capecitabine (1)
- capture (1)
- carbohydrate (1)
- carcinoma (1)
- carcinoma cells (1)
- cardiac hypertrophy (1)
- cardiac thrombi (1)
- cardiac transplantation (1)
- cardiovascular (1)
- care (1)
- carfilzomib (1)
- caspase activation (1)
- caspase-3 (1)
- cathelicidin (1)
- cathelicidin LL37 (1)
- ceftriaxone (1)
- cell (1)
- cell binding (1)
- cell cycle (1)
- cell of origin (1)
- cell therapy and immunotherapy (1)
- cell viability testing (1)
- cell wall (1)
- celldifferentiation (1)
- cellular inhibitor of apoptosis 1/2 (cIAP1/2) (1)
- cereblon expression (1)
- cerebral aspergillosis (1)
- cerebrospinal fluid (1)
- cfRNA (1)
- chemistry (1)
- chemokine receptor (1)
- chenodeoxycholate (1)
- chewed (1)
- children (1)
- chimeric antigen receptors (1)
- cholesterol 25 hydroxylase (1)
- chromosomale Verlustanalyse (1)
- chronic Hepatitis C (1)
- chronic distress (1)
- chronic myeloic leukemia (1)
- chronic myeloid leukemia (1)
- chronic phase (1)
- chronisch entzündliche Darmerkrankungen (1)
- chronische berufliche Exposition (1)
- cicatricial pemphigoid (1)
- circulating (1)
- circulating micrornas (1)
- circulating tumor cells (1)
- cirrhosis (1)
- class-I (1)
- clinical imaging (1)
- clinical trial (1)
- clinical-practice (1)
- clostridium difficile infection (1)
- cluster of differentiation (1)
- coagulation (1)
- cognitive hypnotherapy (1)
- collagens (1)
- colon cancer (1)
- colon carcinoma (1)
- combination testing (1)
- combination therapy (1)
- commensal bacteria (1)
- common genetic determinants (1)
- common variable immunodeficiency (1)
- common variable immunodeficiency (CVID) (1)
- comorbidities (1)
- comparability (1)
- comparison (1)
- complement system (1)
- compliance (1)
- complication (1)
- complications (1)
- comprehensive management (1)
- comprehensive psychosomatic assessment (1)
- consensus statement (1)
- conservation (1)
- contrast-enhanced ultrasound. (1)
- coping (1)
- coping skills (1)
- coronary artery bypass grafting (1)
- corticosteroids and cyclophosphamide (1)
- costimulation (1)
- critically ill patients (1)
- cross presentation (1)
- cross-linking (1)
- cyclophosphamide (FLAMSA) (1)
- cytarabine dose (1)
- cytochrome P450 3A4 (CYP3A4) (1)
- cytogenetic response (1)
- cytogenetics (1)
- cytokine (1)
- cytokine production (1)
- cytokine-induced killer cells (1)
- cytokinesis (1)
- cytopenia (1)
- cytotoxicity receptors (1)
- d3web.Train (1)
- d4T (1)
- dabrafenib (1)
- daratumumab monotherapy (1)
- ddPCR (1)
- death rates (1)
- definition (1)
- degradation (1)
- deletion 17P (1)
- dendritic cell-targeting (1)
- dendritiric cells (1)
- dendritische Zelle (1)
- denritic cells (1)
- derivates (1)
- detoxification (1)
- dexamethasone (1)
- diabetes (1)
- diabetes mellitus type 2 (1)
- diagnostic medicine (1)
- diagnostics (1)
- diarrhea (1)
- different imatinib dose regimens (1)
- differentiated thyroid tumor (1)
- diffuse large B-cell lymphoma (1)
- diffusion weighted mri (1)
- diketopiperazines (1)
- direct-acting antiviral (1)
- direct-acting antivirals (1)
- discharge definition (1)
- discordance (1)
- disease (1)
- disease comorbidities (1)
- disease score (1)
- disease severity (1)
- disease-activity score (1)
- disengagement (1)
- disorder of immunity (1)
- disorders (1)
- dolutegravir (1)
- donor-cell leukemia (1)
- downstream (1)
- drug (1)
- drug adherence (1)
- drug monitoring (1)
- drug resistance (1)
- drug screening (1)
- drug-induced immune hemolytic anemia (1)
- drug–drug interactions (DDIs) (1)
- dual targeting (1)
- duodenal perforation (1)
- duodenal trauma (1)
- e. coli Nissle (1)
- early applied higher imatinib dosages (1)
- early detection (1)
- early onset sepsis (1)
- elderly (1)
- elderly patients (1)
- elderly persons (1)
- electrogastrographic egg activities (1)
- electroporation (1)
- elotuzumab (1)
- emotional regulation (1)
- emtricitabine (1)
- enal impairment (1)
- endoscopic (1)
- endoscopic full thickness resection (eFTR) (1)
- endoscopic instruments (1)
- endoscopic intervention (1)
- endosponge (1)
- engaging aantibody (1)
- engraftment syndrome (1)
- enzyme-linked immunoassays (1)
- epidemiology (1)
- epidemology (1)
- epithelial-mesenchymal transition (1)
- erythropoiesis-stimulating agents (1)
- esophageal perforation (1)
- esophagus (1)
- european leukemia net (1)
- everolimus (1)
- exhaustion (1)
- expression (1)
- extramedullary (1)
- extramedullary hematopoiesis (1)
- familial amyloid polyneuropathy (FAP) (1)
- fatty liver (1)
- fear of cancer (1)
- fever (1)
- fibrin D-dimer (1)
- fibroblast activation protein (1)
- fibrosis progression (1)
- fibrotest (1)
- fine-needle-aspiration (1)
- fluorescence (1)
- fluorescence in situ hybridization (FISH) (1)
- fluorescence microscopy (1)
- fluorescent dyes (1)
- folinic acid (1)
- free survival (1)
- fructose (1)
- full-thickness resection device (FTRD) (1)
- functional abdominal pain (1)
- fungal aerosolization (1)
- fungal disease (1)
- fungal host response (1)
- fungal infection model (1)
- fungal molecular diagnostics (1)
- fungal sinusitis (1)
- fungi (1)
- fusion protein (1)
- gRNA-only (1)
- galectin-2 (1)
- gamma delta T cell (1)
- gamma delta T cells (1)
- gamma delta T-Zelle (1)
- gamma delta T-Zellen (1)
- gastric MALT lymphoma (1)
- gastric bypass (1)
- gastric cancer (1)
- gastric emptying (1)
- gastroduodenoscopie (1)
- gastrointestinal dysfunction (1)
- gastrointestinal infections (1)
- gastrointestinal perforation (1)
- gastrointestinal symptoms (1)
- gastrointestinal tract (1)
- gastrointestinal tumors (1)
- gene expression data (1)
- gene regulation in immune cells (1)
- gene therapy (1)
- gene-environment interaction (1)
- genetic polymorphisms (1)
- genetic susceptibility (1)
- genital warts (1)
- genus (1)
- german people (1)
- glecaprevir/pibrentasvir (1)
- glioblastoma (1)
- glucose (1)
- glutamic acid decarboxylase (1)
- glycaemic index (1)
- gp (1)
- gp130 (1)
- graft-versus-host-disease (1)
- graft-versus-leukemia effect (1)
- graftversushostdisease (1)
- granulocytes (1)
- group 3 (1)
- group consensus statement (1)
- growth differentiation factor 15 (1)
- growth-factor receptor 3 (1)
- growth-factor-receptor (1)
- growthfactors (1)
- gut–liver axis (1)
- haematopoietic stem cell (1)
- haploidentical γδ T lymphocytes (1)
- head and neck cancer (1)
- health-assessment questionnaire (1)
- healthy volunteers (1)
- heart-lung-machine (1)
- heartfailure (1)
- heat shock proteins (1)
- helicase (1)
- helicobacter pylori infection (1)
- hematological malignancies (1)
- hematology (1)
- hematopoetic stem cells (1)
- hematopoietic (1)
- hematopoietic SCT (1)
- hematopoietic cell transplantation (1)
- hematopoietic stem cell transplantation (HSCT) (1)
- hematopoietic stem cells (1)
- hemodialysis (1)
- hemolysis (1)
- hemolytic anemia (1)
- hemostasis (1)
- hepatic stellate cells (1)
- hepatitis (1)
- hepatitis B virus (1)
- hepatitis c (1)
- hepatocellular carcinoma (1)
- hepatoma-derived growth factor (1)
- hepatotoxicity (1)
- high-dose chemotherapy (1)
- high-risk cytogenetics (1)
- high-risk hematology (1)
- highly-active antiretroviral therapy (1)
- homing (1)
- homing receptor (1)
- hospitalization (1)
- host defense (1)
- host genetics (1)
- host response (1)
- host-pathogen interaction (1)
- human (1)
- human biomarker (1)
- human cholangiocellular carcinoma (1)
- human cytomegalovirus (1)
- human hepatic cells (1)
- human intrahepatic cholangiocarcinoma (1)
- human leukocyte antigen-E (HLA-E) (1)
- human multiple-myeloma (1)
- human papillomavirus (1)
- human pathogen (1)
- human pathogenic fungi (1)
- humans (1)
- hybrid messenger RNA (1)
- hydroxy-dabrafenib (1)
- hypersensitivity (1)
- hypnotic susceptibility (1)
- hypogammaglobulinemia (1)
- hämatopoetische Stammzelltransplantation (1)
- i-131 uptake (1)
- iNKT (1)
- iNKT-Zellen (1)
- idiotype (1)
- imaging the immune system (1)
- immune activation (1)
- immune cell recruitment (1)
- immune control (1)
- immune impairment (1)
- immune modulation (1)
- immune monitoring (1)
- immune reaction (1)
- immune receptors (1)
- immune reconstitution (1)
- immune therapy (1)
- immunity (1)
- immuno-oncology (1)
- immunocompromised patients (1)
- immunoglobulin light chain (1)
- immunoglobulin rearrangement (1)
- immunohistochemistry (1)
- immunohistochemistry techniques (1)
- immunophenotyping (1)
- immunotherapeutics (1)
- in vitro Testmodell (1)
- in vitro model (1)
- in vivo cell expansion (1)
- inborn errors of immunity (IEIs) (1)
- incidence (1)
- independent marker (1)
- individualized surgery (1)
- induce cyclooxygenase-2 expression (1)
- induced apoptosis (1)
- induction regimen (1)
- infection detection (1)
- infektion (1)
- inflamatory bowel disease (1)
- inflammasome (1)
- inflammation marker (1)
- inflammation-induced tissue demage (1)
- influencing factors (1)
- infusion (1)
- inhibition (1)
- inhibitor (1)
- inhibitory receptors (1)
- injury (1)
- innalte immunity (1)
- instrument (1)
- insulin signaling (1)
- integrase inhibitor (1)
- integrins (1)
- interaction (1)
- interacts (1)
- interferon alpha (1)
- interferon alpha (IFNα) (1)
- interferon alpha signalling (1)
- interferon gamma (1)
- interferon-alpha (1)
- interferon-free (1)
- intergrin (1)
- intergroupe francophone (1)
- interleukin 1 (1)
- interleukin 13 (1)
- interleukin 18 (1)
- interleukin 1beta (1)
- interleukin 4 (1)
- interleukin 5 (1)
- interleukin 8 (1)
- interleukin-6 (1)
- interleukin-9 (1)
- interleukine 8 (1)
- intermediate dose Ara-C (1)
- intervention (1)
- intestinal barrier (1)
- intestinal-type adenocarcinoma (1)
- intestine (1)
- intramolecular Michael addition (1)
- intratumoral microbiota (1)
- invasive Aspergillose (1)
- invasive Pilzinfektion (1)
- invasive candidiasis (1)
- iohexol (1)
- irinotecan (1)
- iron homeostasis (1)
- iron responisve element (1)
- irritable-bowle-sondrome (1)
- ischemic stroke (1)
- isoforms (1)
- ivory coast (1)
- janus kinase inhibitor (1)
- kardiochirurgisch (1)
- keratin-18 (1)
- kidney (1)
- kidney cancer (1)
- kidney function (1)
- kinase inhibitors (1)
- kinease (1)
- kinesin (1)
- kolorektale Karzinome (1)
- kreuzreaktive T-Zellen (1)
- lactate dehydrogenase cytotoxicity assay (1)
- lactose (1)
- laminin 332 (1)
- large B-cell lymphoma (1)
- large granular lymphocyte (1)
- lasso regression (1)
- left ventricular hypertrophy (1)
- left ventricular mass index (1)
- leitliniengerecht (1)
- lenalidomide-refractory patients (1)
- lentiviral transduction (1)
- leptin (1)
- lesions (1)
- library screening (1)
- life-threatening side-effects (1)
- ligand incompatibility (1)
- ligand trail (1)
- lineage (1)
- lipid metabilism (1)
- lipodystrophy (1)
- lipofection (1)
- liquid biopsy (1)
- liquid chromatography tandem mass spectrometry (LC-MS/MS (1)
- liraglutide (1)
- liver (1)
- liver disease (1)
- liver diseases (1)
- liver fibrosis (1)
- locally advanced disease (1)
- loss-of-function (1)
- low molecular heparin (1)
- lymph node metastases (1)
- lymph node stromal cells (1)
- lymph node transplantation (1)
- lymphocyte activation (1)
- lymphocytes (1)
- lysine biosynthesis (1)
- lysozyme (1)
- mAb engineering (1)
- mRNA (1)
- mRNA translation (1)
- mRNA-Seq (1)
- mRNA-Translation (1)
- mTOR (1)
- magnetic resonance imaging (1)
- malassimilation (1)
- malignant transformation (1)
- malnutrition (1)
- mammalian genomics (1)
- mantle cell lymphoma (1)
- marrow plasma cells (1)
- matrix metallopeptidase-1 (1)
- mebendazole (1)
- mechanical loading (1)
- mechanism (1)
- mechanosensing (1)
- mechanotransduction (1)
- megakaryocytes (1)
- melanoma (1)
- melanoma malignancy (1)
- melanoma therapy (1)
- memory B cell (1)
- mesenteric lymph node (1)
- messenger RNA (1)
- metabolic syndrom (1)
- metabolic tumor volume (MTV) (1)
- metastasis (1)
- metastasis-directed therapy (1)
- methionine (1)
- methotrexate (1)
- methylation (1)
- miR-122 (1)
- miR-132 (1)
- miR-146 (1)
- miR-155 (1)
- microRNA (1)
- microbiota (1)
- microbiota-derived metabolites (1)
- micronuclei (1)
- microsatellite (1)
- microsatellite instability (1)
- microswimmer (1)
- mikrosatelliteninstabil (1)
- mindfulness (1)
- minimal residual disease (1)
- minimally important difference (1)
- minimally invasive surgery (1)
- mismatch (1)
- missing self (1)
- mitochondrial DNA (1)
- mitochondriale Toxizität (1)
- mixed infection (1)
- modified Rodnan skin score (mRSS) (1)
- modified vaccinia Ankara virus (1)
- mold disease (1)
- mold exposure (1)
- molecular data (1)
- molecular diagnosis (1)
- molecular response in cml (1)
- mono specific antibody (1)
- mono spezifischer Antikörper (1)
- monoclonal antibody (1)
- monoclonal gammopathy (1)
- monoclonal-antibodies (1)
- monocytes (1)
- mouse feeding model (1)
- mouse models DNA damage (1)
- mtDNA (1)
- mucormycosis (1)
- mucous membrane pemphigoid (1)
- multicomponent Ugi-type reaction (1)
- multimodal (1)
- multiparameter flow-cytometry (1)
- multiparameter flow-cytpmetry (1)
- multiparametric flow cytometry (1)
- multiple myeloma Lesions (1)
- multiplex PCR (1)
- multiplex-PCR (1)
- multiplicity of infection (1)
- murin (1)
- muscle (1)
- music (1)
- mutation (1)
- mycophenolate (1)
- mycoses (1)
- mycosis (1)
- myeloid-derived suppressor cells (MDSCs) (1)
- myeloma cells (1)
- myofibroblast (1)
- myokines (1)
- nOAC (1)
- naive T-cell gene editing (1)
- nanoparticle albumin-bound paclitaxel (1)
- nasal mucosa (1)
- natural killer cell (1)
- natural language processing (1)
- naïve B cells (1)
- necroptosis (1)
- necrotic cell death (1)
- neoadjuvant (1)
- neoadjuvant chemotherapy (1)
- nestin (1)
- network (1)
- neuralgic amyotrophy (1)
- neuroendocrine neoplasia (1)
- neuroendocrine tumor (NET) (1)
- neurology (1)
- neutropenia (1)
- neutropenic fever (1)
- neutropenie (1)
- neutrophile Granulozyten (1)
- neutrophils (1)
- new species (1)
- newly diagnosed (1)
- newly-diagnosed myeloma (1)
- nichtalkoholische Fettlebererkrankung (1)
- nichtinvasive Bildgebung (1)
- nicotinamide (1)
- no correlation (1)
- nomogram (1)
- non-interventional (1)
- non-invasive fibrosis assessment (1)
- nonalcoholic fatty liver disease (1)
- none (1)
- normal values (1)
- novel therapies (1)
- nuclear factor ‘kappa-light-chain-enhancer’ of activated B-cells (NFκB) (1)
- nuclear localisation sequence (1)
- nuclear pore complex (1)
- nuclear receptors (1)
- nucleocytoplasmatic transport (1)
- nucleoporine (1)
- nucleoside transporter (1)
- nucleotide excision repair (1)
- nukleäre Lokalisationssequenz (1)
- nutritional counseling (1)
- nutritional medical needs (1)
- nutritional risk screening (1)
- obinutuzumab (1)
- observational (1)
- occult gastrointestinal bleeding (1)
- oesophagogastroduodenoscopy (1)
- off-pump (1)
- older patients (1)
- oligmometastases (1)
- oligomerization (1)
- oligorecurrence (1)
- oncobiome (1)
- oncogenic signalling network (1)
- oncologist (1)
- oncology outpatients (1)
- oncostatin M (1)
- onkogenes Signalnetzwerk (1)
- ontology (1)
- operating platform (1)
- ophthalmic artery (1)
- optic nerve (1)
- oral anticancer drugs (1)
- oral anticoagulant therapy (1)
- oral anticoagulants (1)
- oral microbiome (1)
- orale Antikoagulationstherapie (1)
- orale Chemotherapie (1)
- orbit (1)
- orthotopic xenograft (1)
- osimertinib (1)
- osteokines adaptation (1)
- osteonecrosis of the jaw (1)
- osteoradionecrosis (1)
- outbreak (1)
- outcome (1)
- outcomes research (1)
- outpatient (1)
- outreach (1)
- overall survival (1)
- overdose (1)
- oxaliplatin (1)
- p38 MAPK (1)
- p53 (1)
- p8 (1)
- paediatric cancer (1)
- pan-RCC (1)
- pancreatectomy (1)
- pancreatic adenocarcinoma (1)
- pancreatic adenocarcinoma (PDAC) (1)
- pancreatic beta-cells (1)
- pancreatic head cancer (1)
- pancreatic neoplasms (1)
- pancreatobiliary type (1)
- panobinostat (1)
- paradoxe CRAF-Aktivierung (1)
- participation in clinical trials (1)
- pathogen-associated molecular patterns (1)
- pathogenic TP53 germline variant (1)
- pathophysiology (1)
- pathway (1)
- pathways (1)
- patient access (1)
- patient care (1)
- patient-reported outcomes (1)
- patients with multiple myeloma (1)
- pattern (1)
- pattern recognition receptors (1)
- pcr (1)
- pediatric (1)
- pediatric HIV infection (1)
- peginterferon alpha-2B (1)
- peginterferon alpha-2b (1)
- peptide (1)
- peptide tyrosine tyrosine (PYY) (1)
- peptide tyrosine tyrosine 3-36 (PYY\(_{3-36}\)) (1)
- percutaneus endoscopic gastrostomy (1)
- personalised medicine (1)
- personalized medicine (1)
- pharmacokinetic (1)
- pharmacokinetic interaction (1)
- pharmacology (1)
- phosphatidyl-inositol-3-kinase p110 alpha (1)
- phosphatidylinositol 3-kinase/Akt (1)
- physical activity (1)
- physicians (1)
- physiologically based pharmacokinetic (PBPK) modeling (1)
- plasma D-dimer (1)
- plasma cell disorder (1)
- plasma clearance (1)
- platelet activation (1)
- platelet aggregation (1)
- platelet count (1)
- platelets (1)
- plus dexamethasone (1)
- point mutation (1)
- point shear wave elastography (1)
- poly(ADP-ribose) polymerase inhibitors (1)
- polymerase-chain-reaktion (1)
- polymorphonuclear neutrophil (1)
- polymyalgia rheumatica (1)
- polyp (1)
- population pharmacokinetics (1)
- population-based cohort (1)
- porcine large animal model (1)
- positron emission tomography (1)
- positron emission tomography/computed tomography (1)
- post-hospital (1)
- postoperative bleeding (1)
- posttraumatic stress disorder (1)
- potentially bleeding pathologies (1)
- pp65 (1)
- pre-clinical models (1)
- precision medicine (1)
- precision oncology (1)
- prediction (1)
- predictive biomarker (1)
- pregnancy (1)
- prenatal paternal depression (1)
- preoperative planning (1)
- prevalence (1)
- primary biliary cholangitis (1)
- primary immunodeficiencies (1)
- primary immunodeficiency (1)
- primary sclerosing cholangitis (1)
- primary systemic amyloidosis (1)
- primär systemische Amyloidose (1)
- probe-based real-time PCR (1)
- progression (1)
- proliferation of beta-cells (1)
- prolonged cytopenia (1)
- prolonged neutropenia (1)
- prophylaxis (1)
- prospective (1)
- prospective feasibility (1)
- prostaglandin E2 (1)
- prostate-specific membrane antigen (1)
- prostate-specific membrane antigen (PSMA) (1)
- proteasome inhibitors (1)
- protein p8 (1)
- psoriasis (1)
- psychischer Stress (1)
- psychology (1)
- psychoneuroimmunology (1)
- psychosocial (1)
- pulmonary aspergillosis (1)
- pulmonary immune response (1)
- pyrimidine synthesis (1)
- pädiatrische HIV-Infektion (1)
- qRT-PCR (1)
- radiation therapy (1)
- radiogenomics (1)
- radioligand therapy (1)
- radionuclide therapy (1)
- radiotherapy (1)
- rainforest (1)
- raltegravir (1)
- randomized controlled trial (1)
- randomized phase-3 trial (1)
- rapid prototyping (1)
- rare SNP (1)
- real life setting (1)
- real time PCR (1)
- real world data (1)
- real-time (1)
- recall antigen (1)
- receptor expression (1)
- receptor tyrosine kinases (1)
- recognition (1)
- recombinant-human-erythropoietin (1)
- recovery (1)
- rectal sensitivity (1)
- rectum (1)
- recurrence (1)
- recurrent Tako-Tsubo cardiomyopathy (1)
- reference data (1)
- refractory or relapsed (1)
- refraktär (1)
- refraktär und rezidiviert (1)
- region (1)
- relaps (1)
- relapsed (1)
- relapsed and refractory (1)
- relaxation (1)
- renal failure (1)
- renal function (1)
- renal perfusion (1)
- renal scintigraphy (1)
- replikative senescence (1)
- reported outcomes (1)
- reporting and data systems (1)
- respiratory virus (1)
- resting NK cells (1)
- results (1)
- retardeted virus (1)
- retargeted measles virus (1)
- retrospective (1)
- retrospektiv (1)
- reverse transcriptase inhibitors (1)
- review (1)
- rheumatoid (1)
- rheumatoid arhritis (1)
- rheumatoide Arthritis (1)
- ribavirin serum levels (1)
- risk factor (1)
- risk pregnancy (1)
- risk factor analysis (1)
- rituximab (1)
- rs10754558 (1)
- rs35829419 (1)
- ruxolitinib (1)
- safety (1)
- salvage (1)
- sarcoma (1)
- scFv (1)
- scid mice (1)
- screening for distress (1)
- second line therapy (1)
- secondary metabolite gene cluster (1)
- serotonin (1)
- serum biomarkers (1)
- serum concentrations (1)
- serum creatinine (1)
- serum retention (1)
- severe fibrosis (1)
- shRNA (1)
- siRNA (1)
- sialyl Lewis x (1)
- side effects (1)
- signal inhibition (1)
- signalling (1)
- significance MGUS (1)
- silkworm (1)
- single chain (1)
- sirolimus (1)
- skeletal mechanobiology (1)
- skin equivalents (1)
- sleeping sickness (1)
- slice culture (1)
- small bowel bleeding (1)
- small interfering RNAs (1)
- smoldering multiple-myeloma (1)
- smoldering myeloma (1)
- somatic symptom burden (1)
- somatostatin receptor (SSTR) (1)
- soziodemographische Analyse (1)
- spatial heterogeneity (1)
- spectral karyotyping (1)
- stable isotope breath tests (1)
- standardization (1)
- standardized reporting (1)
- steatosis (1)
- stem (1)
- stereotactic body radiotherapy (1)
- stimulation (1)
- strategy (1)
- streptococci (1)
- stress level (1)
- stromal cells (1)
- structural biology (1)
- subcellular localisation (1)
- subunit (1)
- subzelluläre Lokalisation (1)
- sugar replacer (1)
- suicide attempt (1)
- sulfadiazine (1)
- sulfur (1)
- super-resolution microscopy (1)
- superior (1)
- suppression (1)
- surgical care (1)
- surgical manipulator (1)
- susceptibility (1)
- sustained virological response (1)
- symptoms (1)
- systemic candidiasis (1)
- systemic therapy (1)
- t-lymphocytes (1)
- target validation (1)
- targeted therapies (1)
- targeted therapy (1)
- targeting (1)
- taxonomy (1)
- tcells (1)
- tenofovir disaproxil fumarate (1)
- term-follow-up (1)
- thalidomide maintenance (1)
- therapeutic strategy (1)
- therapeutisches Target (1)
- thromboembolism (1)
- thrombopoiesis (1)
- thyroid (1)
- tissue engineering (1)
- tocilizumab (1)
- tocilizumab (IL-6 inhibitor) (1)
- total body irradiation/busulfan (1)
- total lesion glycolysis (TLG) (1)
- total lesion methionine uptake (TLMU) (1)
- toxoplasmosis (1)
- trabectedin (1)
- trail-mediated apoptosis (1)
- trametinib (1)
- transactivation (1)
- transanal endoscopic microsurgery (TEM) (1)
- transcription (1)
- transcriptome (1)
- transcriptome profiling (1)
- transcripts (1)
- transient elastography (1)
- transient regulatory T-cell targeting (1)
- translocation (1)
- transporter protein associated with antigen processing-1 (TAP1) (1)
- transstomal endoluminal vacuum therapy (1)
- transthyretin (1)
- treatment (1)
- treatment failure (1)
- treatment response (1)
- trispecific (1)
- troponin-I (1)
- tsetse fly (1)
- tube nutrition (1)
- tuberculosis (1)
- tumor burden (1)
- tumor microenvironment (1)
- tumor microenvironment (TME) (1)
- tumor necrosis factor (TNF) (1)
- tumor specific antigen (1)
- tumor-associated antigens (1)
- tumor-infiltrating (1)
- tumor-specific CD8+ T cells (1)
- tumormicroenvironment (1)
- tumor‐specific antigen (1)
- tumour immunology (1)
- type 1 diabetes mellitus (1)
- type I interferons (1)
- tyrosine-kinase inhibitor (1)
- ulcerative colitis (1)
- undetermined significance MGUS (1)
- upper gastrointestinal tract (1)
- uridine (1)
- urine alkalinization (1)
- ursodeoxycholic acid (1)
- vaccine vector (1)
- validation (1)
- valve replacement (1)
- vascularization (1)
- vasculature (1)
- vasculitis (1)
- venetoclax (1)
- venous thromboembolic disease (1)
- verteporfin (1)
- video capsule endoscopy (1)
- video object detection (1)
- viral clearance (1)
- viral load (1)
- viral replication (1)
- virulence (1)
- virus (1)
- virus infection (1)
- virus-infected cells (1)
- virus-specific T-cell (1)
- virusspezifische T-Zellen (1)
- vitamin D (1)
- volumetric absorptive micro-sampling (VAMS) (1)
- warfarin interruption (1)
- water load test (1)
- weight gain (1)
- whole blood specimens (1)
- workplace health promotion (1)
- yoga (1)
- zirkulierende Tumorzellen (1)
- zo-1 (1)
- zoledonic acid (1)
- zoledronat (1)
- zoledronate (1)
- zweigeteilte trivalente T-Zell-aktivierende Antikörperderivate (1)
- zytotoxische T-Zellen (1)
- Ängstlichkeit/Depressivität (1)
- Ärztliche Behandlung (1)
- Ösophago-gastro-duodenoskopie (1)
- Ösophagus (1)
- Überlebenszeit (1)
- Übungsprogramm (1)
- β-catenin (1)
- γδ T cells (1)
- γδ T-Zellen (1)
- δγ Lymphozyten (1)
- δγ T cells (1)
Institute
- Medizinische Klinik und Poliklinik II (526) (remove)
Schriftenreihe
Sonstige beteiligte Institutionen
- Johns Hopkins School of Medicine (3)
- Center for Interdisciplinary Clinical Research, Würzburg University, Würzburg, Germany (2)
- Betriebsärztlicher Dienst der Universität Würzburg (1)
- Clinical Trial Center (CTC) / Zentrale für Klinische Studien Würzburg (ZKSW) (1)
- Department of Hematology and Oncology, Sana Hospital Hof, Hof, Germany (1)
- Department of Laboratory Medicine and Medicine Huddinge, Karolinska Institutet and University Hospital, Stockholm, Sweden (1)
- Department of Medicine A, University Hospital of Münster, Münster, Germany (1)
- Early Clinical Trial Unit, Comprehensive Cancer Center Mainfranken (1)
- Experimentelle Tumorimmunologie, Frauenklinik, Universität Würzburg (1)
- Interdisciplinary Center for Clinical Research (IZKF), Würzburg, Germany (1)
ResearcherID
- N-2030-2015 (1)
Despite available diagnostic tests and recent advances, diagnosis of pulmonary invasive aspergillosis (IPA) remains challenging. We performed a longitudinal case-control pilot study to identify host-specific, novel, and immune-relevant molecular candidates indicating IPA in patients post allogeneic stem cell transplantation (alloSCT). Supported by differential gene expression analysis of six relevant in vitro studies, we conducted RNA sequencing of three alloSCT patients categorized as probable IPA cases and their matched controls without Aspergillus infection (66 samples in total). We additionally performed immunoassay analysis for all patient samples to gain a multi-omics perspective. Profiling analysis suggested LGALS2, MMP1, IL-8, and caspase-3 as potential host molecular candidates indicating IPA in investigated alloSCT patients. MMP1, IL-8, and caspase-3 were evaluated further in alloSCT patients for their potential to differentiate possible IPA cases and patients suffering from COVID-19-associated pulmonary aspergillosis (CAPA) and appropriate control patients. Possible IPA cases showed differences in IL-8 and caspase-3 serum levels compared with matched controls. Furthermore, we observed significant differences in IL-8 and caspase-3 levels among CAPA patients compared with control patients. With our conceptual work, we demonstrate the potential value of considering the human immune response during Aspergillus infection to identify immune-relevant molecular candidates indicating IPA in alloSCT patients. These human host candidates together with already established fungal biomarkers might improve the accuracy of IPA diagnostic tools.
Although the field of fungal infections advanced tremendously, diagnosis of invasive pulmonary aspergillosis (IPA) in immunocompromised patients continues to be a challenge. Since IPA is a multifactorial disease, investigation from different aspects may provide new insights, helpful for improving IPA diagnosis. This work aimed to characterize the human immune response to Aspergillus fumigatus in a multilevel manner to identify characteristic molecular candidates and risk factors indicating IPA, which may in the future support already established diagnostic assays. We combined in vitro studies using myeloid cells infected with A. fumigatus and longitudinal case-control studies investigating patients post allogeneic stem cell transplantation (alloSCT) suffering from IPA and their match controls.
Characteristic miRNA and mRNA signatures indicating A. fumigatus-infected monocyte-derived dendritic cells (moDCs) demonstrated the potential to differentiate between A. fumigatus and Escherichia coli infection. Transcriptome and protein profiling of alloSCT patients suffering from IPA and their matched controls revealed a distinctive IPA signature consisting of MMP1 induction and LGAL2 repression in combination with elevated IL-8 and caspase-3 levels. Both, in vitro and case-control studies, suggested cytokines, matrix-metallopeptidases and galectins are important in the immune response to A. fumigatus. Identified IPA characteristic molecular candidates are involved in numerous processes, thus a combination of these in a distinctive signature may increase the specificity. Finally, low monocyte counts, severe GvHD of the gut (grade ≥ 2) and etanercept administration were significantly associated with IPA diagnosis post alloSCT. Etanercept in monocyte-derived macrophages (MDM) infected with A. fumigatus downregulates genes involved in the NF-κB and TNF-α pathway and affects the secretion of CXCL10.
Taken together, identified characteristic molecular signatures and risk factors indicating IPA may in the future in combination with established fungal biomarkers overcome current diagnostic challenges and help to establish tailored antifungal therapy. Therefore, further multicentre studies are encouraged to evaluate reported findings.
Im Rahmen dieser Arbeit wurden Gewebe von jeweils 15 kolorektalen MSI- und CSIPrimärtumoren, sowie 3 MSI- und 2 CSI-Tumorzelllinien mittels SNP-Arrayanalyse molekulargenetisch auf uniparentale Disomie (UPD) untersucht. Es konnte bestätigt werden, dass die uniparentale Disomie ein wichtiger Mechanismus zur Inaktivierung von Tumorsuppressorgenen zu sein scheint. Die Ergebnisse zeigen, dass nicht nur in MSI-Tumoren, sondern auch in CSI-Tumoren UPD nachgewiesen werden konnte, wobei der UPD-Anteil an identifizierten LOH-Regionen in MSI-Tumoren mit 94% gegenüber 41% in CSI-Tumoren deutlich höher lag. Interessanterweise wurde auch in 68% der korrespondierenden MSI- und in 27% der entsprechenden CSINormalgewebe UDP festgestellt, was daraufhin deutet, dass hier möglicherweise schon kanzerogene Vorstufen vorliegen. Die Verteilung der UPDs in den 15 Tumorproben der jeweiligen Tumortypen (MSI und CSI) war innerhalb der einzelnen Proben und innerhalb der einzelnen Chromosomen sehr heterogen, es wurden jedoch gemeinsam Regionen mit UPD gefunden. Bei 27% der MSI-Tumoren wurde eine neue Kandidatenregion auf Chromosom 6 (6pter-p22) identifiziert, die auch einige potentielle Tumorkandidatengene, wie das Tumorsuppressorgen NOL7 oder den Transkriptionsfaktor AP2a enthält. In CSI-Tumoren waren die monoallelischen Regionen mit 59% hauptsächlich durch Deletionen charakterisiert, während die MSITumore im Gegensatz nur 3% Deletionen aufwiesen. In CSI-Tumoren fielen insbesondere vier Bereiche auf den Chromosomen 18, 17, 8 und 22 durch allelische Verluste auf und bestätigen damit eine Reihe von früheren Ergebnissen. In bestimmten Regionen (z.B. 22q12.1) wurden sowohl Deletionen als auch UPD festgestellt. Die Region 5q22.2 war fast auschließlich von uniparentaler Disomie betroffen. Ob die UPD vor allem in frühen Stadien der Kolonkarzinogenese eine Rolle spielt und in späteren Stadien eher in chromosomaler, bzw. Mikrosatelliteninstabilität vorkommt, werden weitere Studien zeigen müssen.
Limiting bone resorption and regenerating bone tissue are treatment goals in myeloma bone disease (MMBD). Physical stimuli such as mechanical loading prevent bone destruction and enhance bone mass in the MOPC315.BM.Luc model of MMBD. It is unknown whether treatment with the Bruton's tyrosine kinase inhibitor CC-292 (spebrutinib), which regulates osteoclast differentiation and function, augments the anabolic effect of mechanical loading. CC-292 was administered alone and in combination with axial compressive tibial loading in the MOPC315.BM.Luc model for three weeks. However, neither CC-292 alone nor its use in combination with mechanical loading was more effective in reducing osteolytic bone disease or rescuing bone mass than mechanical stimuli alone, as evidenced by microcomputed tomography (microCT) and histomorphometric analysis. Further studies are needed to investigate novel anti-myeloma and anti-resorptive strategies in combination with physical stimuli to improve treatment of MMBD.
Bile salts accumulating during cholestatic liver disease are believed to promote liver fibrosis. We have recently shown that chenodeoxycholate (CDC) induces expansion of hepatic stellate cells (HSCs) in vivo, thereby promoting liver fibrosis. Mechanisms underlying bile salt-induced fibrogenesis remain elusive. We aimed to characterize the effects of different bile salts on HSC biology and investigated underlying signaling pathways. Murine HSCs (mHSCs) were stimulated with hydrophilic and hydrophobic bile salts. Proliferation, cell mass, collagen deposition, and activation of signaling pathways were determined. Activation of the human HSC cell line LX 2 was assessed by quantification of α-smooth muscle actin (αSMA) expression. Phosphatidyl-inositol-3-kinase (PI3K)-dependent signaling was inhibited both pharmacologically and by siRNA. CDC, the most abundant bile salt accumulating in human cholestasis, but no other bile salt tested, induced Protein kinase B (PKB) phosphorylation and promoted HSC proliferation and subsequent collagen deposition. Pharmacological inhibition of the upstream target PI3K-inhibited activation of PKB and pro-fibrogenic proliferation of HSCs. The PI3K p110α-specific inhibitor Alpelisib and siRNA-mediated knockdown of p110α ameliorated pro-fibrogenic activation of mHSC and LX 2 cells, respectively. In summary, pro-fibrogenic signaling in mHSCs is selectively induced by CDC. PI3K p110α may be a potential therapeutic target for the inhibition of bile salt-induced fibrogenesis in cholestasis.
Aspergillus (A.) fumigatus is an opportunistic fungal mold inducing invasive aspergillosis (IA) in immunocompromised patients. Although antifungal activity of human natural killer (NK) cells was shown in previous studies, the underlying cellular mechanisms and pathogen recognition receptors (PRRs) are still unknown. Using flow cytometry we were able to show that the fluorescence positivity of the surface receptor CD56 significantly decreased upon fungal contact. To visualize the interaction site of NK cells and A. fumigatus we used SEM, CLSM and dSTORM techniques, which clearly demonstrated that NK cells directly interact with A. fumigatus via CD56 and that CD56 is re-organized and accumulated at this interaction site time-dependently. The inhibition of the cytoskeleton showed that the receptor re-organization was an active process dependent on actin re-arrangements. Furthermore, we could show that CD56 plays a role in the fungus mediated NK cell activation, since blocking of CD56 surface receptor reduced fungal mediated NK cell activation and reduced cytokine secretion. These results confirmed the direct interaction of NK cells and A. fumigatus, leading to the conclusion that CD56 is a pathogen recognition receptor. These findings give new insights into the functional role of CD56 in the pathogen recognition during the innate immune response.
Background
Causality between hepatitis B virus (HBV) infection and diffuse large B-cell lymphoma (DLBCL) was reported in various studies. However, the implication of different virological serum markers of HBV infection in patients with both HBV infection and DLBCL is not fully understood. The aim of this study was to investigate the impact of HBV markers on overall survival (OS) and progression-free survival (PFS) in patients with both HBV infection and DLBCL.
Methods
In this study, patients (n = 40) diagnosed with both HBV infection and DLBCL were identified between 2000 and 2017. Six patients with hepatitis C virus (HCV) and/or human immunodeficiency virus (HIV) co-infection were excluded from this study. We retrospectively analyzed patients’ demographic characteristics, treatment, and the prognostic impact of different HBV markers at first diagnosis of DLBCL (HBsAg, anti-HBs, HBeAg, anti-HBe, and HBV-DNA) on OS and PFS.
Results
The majority of patients (n = 21, 62%) had advanced disease stage (III/IV) at diagnosis. In the first-line therapy, 24 patients (70%) were treated with R-CHOP regimen (rituximab, cyclophosphamide, hydroxydaunorubicin, vincristine, and prednisolone). HBeAg positive patients had a trend toward inferior OS and PFS compared with HBeAg negative patients. Anti-HBe positive patients had a statistically significant better OS and PFS compared with anti-HBe negative group (both P < .0001). Viremia with HBV-DNA ≥ 2 × 107 IU/L had a significant negative impact on OS and PFS (both P < .0001).
Conclusion
High activity of viral replication is associated with a poor survival outcome of patients with both HBV infection and DLBCL.
We herein report the case of a 73‐year‐old male patient who was diagnosed with leukemic non‐nodal MCL. This patient had received six cycles of bendamustine, which resulted in a transient remission, and a second‐line therapy with ibrutinib, which unfortunately failed to induce remission. We started a treatment with single‐agent obinutuzumab at a dose of 20 mg on day 1, 50 mg on day 2‐4, 330 mg on day 5, and 1000 mg on day 6. The laboratory analysis showed a rapid decrease of leukocyte count. Four weeks later, we repeated the treatment with obinutuzumab at a dose of 1000 mg q4w and started a therapy with venetoclax at a dose of 400 mg qd, which could be increased to 800 mg qd from the third cycle. This combination therapy was well tolerated. The patient achieved a complete remission (CR) after three cycles of obinutuzumab and venetoclax. To date, the patient has a progression‐free survival of 17 months under ongoing obinutuzumab maintenance q4w. This is the first report about obinutuzumab and venetoclax induced CR in rituximab‐intolerant patient with an ibrutinib‐resistant MCL. This case suggests that obinutuzumab‐ and venetoclax‐based combination therapy might be salvage therapy in patients with ibrutinib‐resistant MCL.