Refine
Has Fulltext
- yes (11)
Is part of the Bibliography
- yes (11)
Document Type
- Journal article (11)
Language
- English (11) (remove)
Keywords
- fear conditioning (3)
- transcranial direct current stimulation (2)
- Alzheimer's disease (1)
- Alzheimers disease (1)
- Alzheimer’s disease (1)
- DNA damage (1)
- FMRI (1)
- FNIRS (1)
- NPU (1)
- RTMS (1)
- activation (1)
- apolipoprotein-E4 (1)
- assay (1)
- association (1)
- auditory cortex (1)
- brain (1)
- brain stimulation (1)
- cognitive decline (1)
- cognitive impairment (1)
- cytome biomarkers (1)
- dementia (1)
- diagnosis (1)
- dorsolateral prefrontal cortex (1)
- e-learning (1)
- early-onset predictors (1)
- elderly (1)
- emotional regulation (1)
- fear memory consolidation (1)
- guidelines & recommendations (1)
- humans (1)
- learning (1)
- life (1)
- medial prefrontal cortex (mPFC) (1)
- medical education (1)
- memory consolidation and extinction (1)
- mild cognitive impairment (1)
- minimum reporting standards (1)
- near-infrared spectroscopy (1)
- neural activity (1)
- objective structured clinical examination (1)
- peripheral-blood lymphocytes (1)
- positron-emission-tomography (1)
- prevention (1)
- psychiatry (1)
- right inferior frontalgyrus (1)
- skin conduction response (1)
- smoking cessation (1)
- sustained fear (1)
- tDCS (1)
- transcranial magnetic stimulation (1)
- transcranial magnetic stimulation (TMS) (1)
- transcutaneous auricular vagus nerve stimulation (1)
- transcutaneous cervical vagus nerve stimulation (1)
- transcutaneous vagus nerve stimulation (1)
- ventromedial prefrontal cortex (1)
- verbal fluency task (1)
Institute
- Klinik und Poliklinik für Psychiatrie, Psychosomatik und Psychotherapie (10)
- Institut für Psychologie (3)
- Institut für Allgemeinmedizin (1)
- Institut für Klinische Neurobiologie (1)
- Institut für Pharmakologie und Toxikologie (1)
- Klinik und Poliklinik für Hals-, Nasen- und Ohrenkrankheiten, plastische und ästhetische Operationen (1)
- Klinik und Poliklinik für Kinder- und Jugendpsychiatrie, Psychosomatik und Psychotherapie (1)
Objective. Several neuroscience tools showed the involvement of auditory cortex in chronic tinnitus. In this proof-of-principle study we probed the capability of functional near-infrared spectroscopy (fNIRS) for the measurement of brain oxygenation in auditory cortex in dependence from chronic tinnitus and from intervention with transcranial magnetic stimulation. Methods. Twenty-three patients received continuous theta burst stimulation over the left primary auditory cortex in a randomized sham-controlled neuronavigated trial (verum = 12; placebo = 11). Before and after treatment, sound-evoked brain oxygenation in temporal areas was measured with fNIRS. Brain oxygenation was measured once in healthy controls (n = 12). Results. Sound-evoked activity in right temporal areas was increased in the patients in contrast to healthy controls. Left-sided temporal activity under the stimulated area changed over the course of the trial; high baseline oxygenation was reduced and vice versa. Conclusions. By demonstrating that rTMS interacts with auditory evoked brain activity, our results confirm earlier electrophysiological findings and indicate the sensitivity of fNIRS for detecting rTMS induced changes in brain activity. Moreover, our findings of trait-and state-related oxygenation changes indicate the potential of fNIRS for the investigation of tinnitus pathophysiology and treatment response.