Refine
Has Fulltext
- yes (61)
Is part of the Bibliography
- yes (61)
Year of publication
Document Type
- Journal article (61)
Language
- English (61) (remove)
Keywords
- ischemic stroke (6)
- cochlear implantation (3)
- mechanical thrombectomy (3)
- neutrophils (3)
- thrombo-inflammation (3)
- 3D fluoroscopy (2)
- Childhood medulloblastoma (2)
- Clinical Neuroradiology (2)
- Radiotherapy (2)
- acute ischemic stroke (2)
- aortic arch (2)
- atherosclerosis (2)
- cerebellar tDCS (2)
- chemotherapy (2)
- editorial (2)
- fpVCT (2)
- immunohistochemistry (2)
- intraoperative imaging (2)
- ischemic penumbra (2)
- magnetic resonance imaging (2)
- middle cerebral artery occlusion (2)
- mouse (2)
- multiple sclerosis (2)
- neurology (2)
- radiotherapy (2)
- split-belt treadmill (2)
- stroke (2)
- surgery (2)
- temporal bone (2)
- three-dimensional imaging (2)
- 3 D rotational fluoroscopy (1)
- 3D analysis (1)
- 4D flow (1)
- 4D flow MRI (1)
- APERIO (1)
- APERIO Hybrid (1)
- AT/RT (1)
- Activation (1)
- Adolescents (1)
- Alemtuzumab (1)
- Alzheimer’s dementia (1)
- Atherosclerosis, intracranial arteries (1)
- B cells (1)
- B7-H1 Antigen (1)
- Brain atrophy (1)
- CD52 (1)
- CDL (1)
- CMR (1)
- CNS (1)
- CNS imaging (1)
- COVID-19 (1)
- CT (1)
- CTLA-4 Antigen (1)
- CXCL4 (1)
- CXCL7 (1)
- Chemotherapy (1)
- Childrens-cancer (1)
- Chronic heart failure (1)
- Cisplatin (1)
- Clinical Genetics (1)
- Clinical trial (1)
- Cochlear duct length (1)
- Cochlear planning software (1)
- Cognitive decline (1)
- Covid-19 (1)
- DWI (1)
- Down-regulation (1)
- Drug Therapy, Combination (1)
- EAE (1)
- EU‐RHAB Registry (1)
- Extraocular eye muscles (1)
- Fabry disease (1)
- Fibroblasts (1)
- GFAP (1)
- Gene (1)
- Glial fibrillary acidic protein (1)
- HD (1)
- HMGB1 (1)
- High-dose chemotherapy (1)
- Induced apoptosis (1)
- Lines (1)
- MPI (1)
- MPS (1)
- MR neurography (1)
- MRI (1)
- MS (1)
- MSCT (1)
- MTX (1)
- Medulloblastoma (1)
- Melanoma-cells (1)
- Memory dysfunction (1)
- Meniere’s disease (1)
- Metastases (1)
- Mucopolysaccharidosis IIIa (1)
- NAP-2 (1)
- NETs (1)
- NOAC (1)
- Orai2 (1)
- PET/CT (1)
- PF4 (1)
- PWV (1)
- Paediatric (1)
- Parkinson’s disease (1)
- Phase II trials (1)
- Phase-II (1)
- Primitive neuroectodermal (1)
- Programmed Cell Death 1 Receptor (1)
- R-CHOP (1)
- Recurrent medulloblastoma (1)
- Reirradiation (1)
- Relapse (1)
- Rhabdoid 2007 (1)
- Rhabdomyosarcoma (1)
- Secondary tumours (1)
- Skin Neoplasms (1)
- Suprascapular nerve (1)
- Survival (1)
- T-cells (1)
- Therapy (1)
- Treatment (1)
- Trial (1)
- Tumors (1)
- WSS (1)
- adverse events (1)
- age (1)
- anatomy (1)
- aneurysm (1)
- aneurysm surgery (1)
- angiography (1)
- balance (1)
- biochemical assays (1)
- biomarker (1)
- biomedical engineering (1)
- blood–brain barrier (1)
- bone imaging (1)
- brain cancer (1)
- brain endothelium (1)
- carotid atherosclerosis (1)
- carotid stenosis (1)
- carotid ultrasound (1)
- cerebral ischemia (1)
- cerebral vasospasm (1)
- cerebrovascular disorders (1)
- cervical dystonia (1)
- characterization and analytical techniques (1)
- chemokines (1)
- childhood cancer (1)
- children (1)
- cholinergic activity (1)
- classification (1)
- clinical trials (1)
- clip control (1)
- cognitive impairment (1)
- collateral circulation (1)
- compression syndrome (1)
- computed tomography (1)
- consolidation (1)
- continuous theta burst stimulation (cTBS) (1)
- contrast (1)
- cortical excitability (1)
- cortical silent period (1)
- crosslinked coating (1)
- degree of stenosis (1)
- diabetic polyneuropathy (1)
- diagnosis (1)
- diagnosis in Fabry disease (1)
- diagnostic delay (1)
- diffuse large B-cell lymphoma (1)
- disease risk-factors (1)
- dorsal root ganglion (1)
- editorial board (1)
- edoxaban (1)
- electrical and electronic engineering (1)
- electromagnetic navigation (1)
- electromyographic (1)
- encephalopathy (1)
- endoglin (1)
- endotheliitis (1)
- experimental stroke (1)
- facial nerve (1)
- fibromyalgia syndrome (1)
- fiducial registration error (1)
- flexible CO2 laser (1)
- flow (1)
- flow dynamics (1)
- fluoroscopy (1)
- frameless systems (1)
- functional MRI (1)
- gait (1)
- gene variant (1)
- genotype-phenotype correlation (1)
- genotype/phenotype correlation (1)
- german multicenter (1)
- giant cell arteritis (1)
- glycoprotein VI (1)
- glycoprotein receptor Ib (1)
- glycoprotein receptor Ibα (1)
- guality-of-life (1)
- heart failure (1)
- hemorrhagic transformation (1)
- hepatitis B virus (1)
- hypoxia (1)
- image quality (1)
- imaging (1)
- imaging agents (1)
- imaging changes (1)
- integrin α2 (1)
- interelectrode-distance (1)
- intracranial bleeding (1)
- intraoperative (1)
- intraventricular therapy (1)
- journal (1)
- jugular paraganglioma (1)
- large artery vasculitis (1)
- large vessel occlusion (1)
- laser surgery (1)
- lateral skull base (1)
- length of stenosis (1)
- leukocytes (1)
- levodopa-induced dyskinesia (1)
- locomotor adaptation (1)
- long-term survivors (1)
- lymphoma (1)
- lysosomal storage disease (1)
- magnetic properties (1)
- magnetic properties and materials (1)
- magnetic resonance neurography (1)
- mapping (1)
- mass index (1)
- medical imaging (1)
- medulloblastoma (1)
- mice (1)
- microscopy (1)
- motor-evoked potentials (MEP) (1)
- nanoparticles (1)
- neck circumference (1)
- neurofilament light chain (1)
- neurological complications (1)
- neuropathic pain (1)
- neuropathy (1)
- neurosurgery (1)
- neurovascular disorders (1)
- onset craniopharyngioma (1)
- ophthalmic artery (1)
- optic nerve (1)
- orbit (1)
- otology (1)
- outcome (1)
- p.R245H (1)
- p.S298P (1)
- pediatric brain tumor (1)
- pediatric low‐grade glioma (1)
- peripheral nerve involvement (1)
- peripheral nervous system (1)
- phosphorylated tau protein (1)
- plaque (1)
- plaque characteristics (1)
- platelets (1)
- post-processing (1)
- prognosis (1)
- progression (1)
- proton beam therapy (1)
- pulse wave velocity (1)
- quantification (1)
- radial (1)
- re-irradiation (1)
- recombinant tissue-type plasminogen activator (1)
- recurrent (1)
- refractory (1)
- renal function (1)
- reperfusion injury (1)
- research activity (1)
- risk of fall (1)
- saccotomy (1)
- secondary reconstruction (1)
- self-navigation (1)
- shedding (1)
- shoulder neurolysis (1)
- software (1)
- stent-retriever device (1)
- stereotaxy (1)
- subarachnoid hemorrhage (1)
- subcutaneous adipose-tissue (1)
- suprascapular notch (1)
- surgical management of paraganglioma (1)
- tMCAO (1)
- thrombemboli (1)
- thromboemboli (1)
- to-height ratio (1)
- tomography (1)
- transcranial magnetic simulation (TMS) (1)
- transient middle cerebral artery occlusion (1)
- tympanic paraganglioma (1)
- tympanojugular paraganglioma (1)
- vasa vasorum (1)
- vertebral artery (1)
- vessel diameter (1)
- vessel patency (1)
- vestibular aqueduct (VA) (1)
- visceral adiposity (1)
- wall shear stress (1)
Institute
- Institut für diagnostische und interventionelle Neuroradiologie (ehem. Abteilung für Neuroradiologie) (61) (remove)
Sonstige beteiligte Institutionen
Background:
To study whether and how c-MYC expression determines response to radio-and chemotherapy in childhood medulloblastoma (MB).
Methods:
We used DAOY and UW228 human MB cells engineered to stably express different levels of c-MYC, and tested whether c-MYC expression has an effect on radio-and chemosensitivity using the colorimetric 3-(4,5-dimethylthiazol- 2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium inner salt (MTS) assay, clonogenic survival, apoptosis assays, cell cycle analysis, and western blot assessment. In an effort to validate our results, we analyzed c-MYC mRNA expression in formalin-fixed paraffin-embedded tumor samples from well-documented patients with postoperative residual tumor and compared c-MYC mRNA expression with response to radio-and chemotherapy as examined by neuroradiological imaging.
Results:
In DAOY -and to a lesser extent in UW228 -cells expressing high levels of c-MYC, the cytotoxicity of cisplatin, and etoposide was significantly higher when compared with DAOY/UW228 cells expressing low levels of c-MYC. Irradiation-and chemotherapy-induced apoptotic cell death was enhanced in DAOY cells expressing high levels of c-MYC. The response of 62 of 66 residual tumors was evaluable and response to postoperative radio-(14 responders (CR, PR) vs. 5 non-responders (SD, PD)) or chemotherapy (23 CR/PR vs. 20 SD/PD) was assessed. c-MYC mRNA expression was similar in primary MB samples of responders and non-responders (Mann-Whitney U test, p = 0.50, ratio 0.49, 95% CI 0.008-30.0 and p = 0.67, ratio 1.8, 95% CI 0.14-23.5, respectively).
Conclusions:
c-MYC sensitizes MB cells to some anti-cancer treatments in vitro. As we failed to show evidence for such an effect on postoperative residual tumors when analyzed by imaging, additional investigations in xenografts and larger MB cohorts may help to define the exact function of c-MYC in modulating response to treatment.