Refine
Has Fulltext
- yes (11)
Is part of the Bibliography
- yes (11)
Document Type
- Journal article (11)
Language
- English (11) (remove)
Keywords
- pediatric adrenocortical cancer (2)
- pediatric adrenocortical tumor (2)
- therapy (2)
- transplantation (2)
- AT/RT (1)
- B cell (1)
- C-reactive protein (1)
- ESPED (1)
- EU‐RHAB Registry (1)
- Rhabdoid 2007 (1)
- T and NK development (1)
- Trousseau's syndrome (1)
- acute (1)
- acute ITP (1)
- acute graft-versus-host disease (1)
- alloreactive T cells (1)
- autoimmunity (1)
- autophagy (1)
- bleeding score (1)
- cardiogenic (1)
- cell therapy (1)
- childhood leukemia (1)
- children (1)
- desmoplastic small round cell tumor (1)
- effector cells (1)
- exercise testing (1)
- exercise tolerance (1)
- extracorporeal membrane oxygenation (1)
- graft-versus host (1)
- hospital exemption (1)
- intravenous immunoglobulins (1)
- leukemia (1)
- maintenance therapy (1)
- mesenchymal stromal cell (1)
- metabolism (1)
- mitophagy (1)
- mouse models (1)
- myeloid (1)
- newly diagnosed ITP (1)
- pediatric adrenocortical adenoma (1)
- pediatric adrenocortical carcinoma (1)
- pediatric brain tumor (1)
- pediatric immune thrombocytopenia (1)
- pediatric stem cell transplantation (1)
- physical activity (1)
- prediction (1)
- prognostic factors (1)
- radiotherapy (1)
- refractory aGvHD (1)
- septic (1)
- shock (1)
- soft tissue sarcoma (1)
- steroid-resistant aGvHD (1)
- treatment (1)
- treatment guidelines (1)
Institute
- Kinderklinik und Poliklinik (10)
- Comprehensive Cancer Center Mainfranken (2)
- Klinik und Poliklinik für Allgemein-, Viszeral-, Gefäß- und Kinderchirurgie (Chirurgische Klinik I) (2)
- Medizinische Klinik und Poliklinik I (2)
- Abteilung für Molekulare Innere Medizin (in der Medizinischen Klinik und Poliklinik II) (1)
- Institut für diagnostische und interventionelle Neuroradiologie (ehem. Abteilung für Neuroradiologie) (1)
- Klinik für Anaesthesiologie (bis 2003) (1)
- Medizinische Klinik und Poliklinik II (1)
- Pathologisches Institut (1)
- Theodor-Boveri-Institut für Biowissenschaften (1)
B cells and DCs are suspected to play an important role in the pathogenesis of cGvHD, which is a serious complication of HSCT with high morbidity. It is characterized by immune responses of donor immune cells against recipient-derived antigens. athogenesis is not yet fully understood, however reconstitution of B cells after HSCT has similarities to physiologic ontogeny. Immunophenotyping and co-cultivation-experiments of B cells and DCs from pediatric patients with cGvHD as well as healthy donors were conducted. Significant differences between patients and healthy donors were observed with increased memory, transitional, CD69+ and CD86+ phenotype and lower levels of naïve B cells due to apoptosis. Co-cultivation revealed this to be primarily B cell-dependent without major effects of and with DCs. There was a decreased CD11c- phenotype in patients and less apoptosis of DCs. Our data suggest a disturbed homeostasis in B cells with increased memory phenotype in patients, whereas DCs could not influence these differences, therefore DCs are not imposing as promising targets. B cell-dependent approaches should be further investigated.