Refine
Has Fulltext
- yes (11)
Is part of the Bibliography
- yes (11)
Document Type
- Journal article (11)
Language
- English (11) (remove)
Keywords
- ADHD (2)
- Early-onset (2)
- OCD (2)
- 5-HT receptors (1)
- Attention-deficit/hyperactivity disorder (1)
- CNV (1)
- Childhood (1)
- Comorbidity survey replication (1)
- DSM-IV disorders (1)
- De-novo (1)
- EEG (1)
- Enrichment analysis (1)
- Follow-up (1)
- MRI (1)
- Medicine (1)
- Metaanalysis (1)
- Prevalence (1)
- Scale (1)
- TIC disorders (1)
- Therapy (1)
- Tourette syndrome (1)
- age (1)
- attention deficit/hyperactivity disorder (ADHD) (1)
- attention-deficit/hyperactivity disorder (ADHD) (1)
- attention‐deficit (1)
- autism (1)
- biomarkers (1)
- brain (1)
- brain asymmetry (1)
- brain laterality (1)
- caudate nucleus (1)
- common SNPS (1)
- complex diseases (1)
- control strain (1)
- dopamine transporter (DAT) (1)
- electroencephalogram (EEG) (1)
- expression (1)
- fMRI (1)
- family (1)
- family relations (1)
- female aggression (1)
- gender (1)
- genetics (1)
- gilles (1)
- glycogen synthase kinase-3 β (GSK-3β) (1)
- glycogen synthase kinase-3β (1)
- hyperactivity disorder (1)
- insulin receptor (IR) (1)
- insulin resistance (1)
- lactosylceramide alpha-2,3-sialyltransferase (ST3GAL5) (1)
- large‐scale data (1)
- learning and memory (1)
- methylphenidate (1)
- mice (1)
- missing heritability (1)
- myelination (1)
- neurobiology (1)
- neuroimaging (1)
- neuropsychiatric disorders (1)
- neuropsychology (1)
- parents (1)
- predation stress (1)
- responsivity (1)
- schoolchildren (1)
- selective mutism (1)
- sex differences (1)
- single photon emission computed tomography (SPECT) (1)
- spontaneously hypertensive rat (1)
- striatum (1)
- structural MRI (1)
- tetrahydroisoquinoline derivates (1)
- tics (1)
- tryptophan hydroxylase-2 (Tph2) (1)
Institute
- Klinik und Poliklinik für Kinder- und Jugendpsychiatrie, Psychosomatik und Psychotherapie (6)
- Klinik und Poliklinik für Psychiatrie, Psychosomatik und Psychotherapie (3)
- Lehrstuhl für Molekulare Psychiatrie (2)
- Neurologische Klinik und Poliklinik (2)
- Institut für Psychologie (1)
- Klinik und Poliklinik für Nuklearmedizin (1)
Background:
Early-onset obsessive-compulsive disorder (OCD) is one of the more common mental illnesses of children and adolescents, with prevalence of 1% to 3%. Its manifestations often lead to severe impairment and to conflict in the family. In this review, we summarize the manifestations, comorbidity, pathophysiology, and course of this disease as well as current modes of diagnosis and treatment.
Methods:
We selectively review the relevant literature and the German-language guidelines for the diagnosis and treatment of mental illnesses in children and adolescents.
Results:
Obsessive-compulsive manifestations are of many types and cause severe impairment. Comorbid mental disturbances are present in as many as 70% of patients. The disease takes a chronic course in more than 40% of patients. Cognitive behavioral therapy is the treatment of first choice, followed by combination pharmacotherapy including selective serotonin reuptake inhibitors (SSRI) and then by SSRI alone.
Conclusion:
OCD often begins in childhood or adolescence. There are empirically based neurobiological and cognitive-behavioral models of its pathophysiology. Multiaxial diagnostic evaluation permits early diagnosis. Behavioral therapy and medications are highly effective treatments, but the disorder nonetheless takes a chronic course in a large percentage of patients.