Refine
Has Fulltext
- yes (248)
Is part of the Bibliography
- yes (248)
Year of publication
Document Type
- Journal article (248) (remove)
Keywords
- depression (19)
- anxiety (13)
- ADHD (12)
- Medizin (12)
- schizophrenia (12)
- DNA methylation (8)
- Schizophrenie (8)
- fMRI (7)
- genetics (7)
- bipolar disorder (6)
- hippocampus (6)
- mice (6)
- COVID-19 (5)
- Quantitative anatomy (5)
- antidepressant (5)
- epigenetics (5)
- fear conditioning (5)
- neuroprotection (5)
- Alzheimer’s disease (4)
- Leonhard classification (4)
- NPY (4)
- Psychiatrie (4)
- behavior (4)
- brain (4)
- dentate gyrus (4)
- fNIRS (4)
- gene expression (4)
- genome-wide association (4)
- major depression (4)
- mental disorders (4)
- mental health (4)
- mouse model (4)
- near-infrared spectroscopy (4)
- oxidative stress (4)
- panic disorder (4)
- prefrontal cortex (4)
- pregnancy (4)
- psychiatry (4)
- working memory (4)
- 5-HT1A (3)
- 5-HT2C (3)
- Albino rats (3)
- Alzheimers disease (3)
- BDNF (3)
- Bipolar disorder (3)
- Cerebellar cortex (3)
- Depression (3)
- EEG (3)
- Leonhard-Klassifikation (3)
- MDD (3)
- Parkinson’s disease (3)
- Purkinje cells (3)
- Schizophrenia (3)
- age (3)
- amygdala (3)
- antidepressants (3)
- association (3)
- children (3)
- chronic heart failure (3)
- cognitive impairment (3)
- dopamine (3)
- emotion (3)
- emotional regulation (3)
- glucocorticoid receptor (3)
- glucose transporter (3)
- humans (3)
- major depressive disorder (3)
- neurodegeneration (3)
- neuroimaging (3)
- neuroinflammation (3)
- neuropathology (3)
- polygenic risk score (3)
- psychiatric disorders (3)
- serotonin (3)
- stress (3)
- substantia nigra (3)
- 5-HT transporter (2)
- 5-HT1A receptor (2)
- 5-HTTLPR (2)
- Alzheimer's disease (2)
- Big Five (2)
- CSF (2)
- Cerebellum (2)
- Coexpression (2)
- Cytokines (2)
- DNA (2)
- Emotional processing (2)
- FAAH (2)
- FKBP5 (2)
- FMRI (2)
- Fibromyalgia syndrome (2)
- HPA axis (2)
- IAPS (2)
- Lipofuscin (2)
- MEG (2)
- MRI (2)
- Mice (2)
- OCD (2)
- P300 (2)
- PARK2 (2)
- Parkinson's disease (2)
- Psychiatric disorders (2)
- Psychopathologie (2)
- Stereology (2)
- activation (2)
- active zone (2)
- adolescence (2)
- adversity (2)
- aggression (2)
- aging (2)
- alliance (2)
- alpha-synuclein (2)
- animal behavior (2)
- anterior cingulate cortex (2)
- anxiety disorders (2)
- biomarker (2)
- biomarkers (2)
- cerebellum (2)
- coping (2)
- cortical activation (2)
- dementia (2)
- disease progression (2)
- disorder (2)
- dorsolateral prefrontal cortex (2)
- early recognition (2)
- efficacy (2)
- electroencephalography (2)
- endocannabinoid (2)
- expression (2)
- extinction (2)
- fear (2)
- fear generalization (2)
- fear-potentiated startle (2)
- fibromyalgia (2)
- frontotemporal dementia (2)
- functional magnetic resonance imaging (2)
- gene (2)
- hiPSC (2)
- human behaviour (2)
- illness (2)
- immediate early genes (2)
- inflammation (2)
- insulin receptor (2)
- iron (2)
- knockout (2)
- knockout mice (2)
- lactation (2)
- learning (2)
- life events (2)
- long-term potentiation (2)
- longitudinal studies (2)
- mutation (2)
- myelination (2)
- myocardial infarction (2)
- negative affect (2)
- neurodevelopment (2)
- neuromelanin (2)
- neuropsychiatric disorders (2)
- neuropsychology (2)
- obesity (2)
- oligodendrocyte (2)
- pain (2)
- parietal hypoactivation (2)
- peripartum (2)
- pharmacovigilance (2)
- physiology (2)
- plasticity (2)
- prediction (2)
- prevention (2)
- proteomics (2)
- psychopathology (2)
- quality of life (2)
- rat (2)
- reaction time (2)
- regulatory T cells (2)
- reliability (2)
- response inhibition (2)
- sensitivity (2)
- serotonin transporter (2)
- serotonin transporter gene (2)
- social decision-making (2)
- startle reflex (2)
- substantia nigra pars compacta (2)
- suicide prevention (2)
- systematic review (2)
- temporoparietal junction (2)
- therapeutic drug monitoring (2)
- transcranial direct current stimulation (2)
- triple in situ hybridization (2)
- tryptophan (2)
- "Familiär-sporadisch"- Konzept (1)
- 123I-mIBG (1)
- 1p13.3 (1)
- 1q21 (1)
- 5-HT (1)
- 5-HTT knockout mice (1)
- 5HTTLPR (1)
- 7q11.2 (1)
- ADHD patients (1)
- Abelson helper integration-1 (AHI1) (1)
- Activation (1)
- Acute tryptophan depletion (1)
- Adult (1)
- Adult head (1)
- Affective psychoses (1)
- Ageing (1)
- Aggressive behaviour (1)
- Albino rat (1)
- Albinoratten (1)
- Alien limb syndrome (1)
- Alzheimer disease (1)
- Alzheimer-Krankheit (1)
- Alzheimer’s dementia (1)
- Anarchic limb syndrome (1)
- Ankyrin (1)
- Antidepressants (1)
- Anxiety (1)
- Anxiety-like behavior (1)
- Association study (1)
- Attention Deficit Hyperactivity Disorder (ADHD) (1)
- Auditory pathway (1)
- Auditory targets (1)
- Axonal degeneration (1)
- B 37 CAG repeat locus (1)
- BDNF Val66Met (1)
- Balints-Syndrome (1)
- Beer-lambert law (1)
- Bias (1)
- Biomarke (1)
- Biomarkers (1)
- Blood-brain barrier (1)
- Body weight (1)
- Brain (1)
- Brain atrophy (1)
- Brain mappins (1)
- Brain trauma (1)
- C(-1019)G polymorphism (1)
- C-reactive protein (1)
- CA3 (1)
- CA4 (1)
- CAPS (1)
- CDH13 (1)
- CDH13 Expression (1)
- CDH13 mRNA (1)
- CLN3 (1)
- CNS (1)
- CNV (1)
- CNVs (1)
- COMT VAL(158)MET polymorphism (1)
- CRH1 (1)
- CRISPR-Cas Systems (1)
- Cadherin (CDH13) (1)
- Cadherin-13 (CDH13) (1)
- Capillaries (1)
- Case-Control Studies (1)
- Caudate nucleus (1)
- Cerebellar nuclei (1)
- Cerebrolysin (1)
- Chronic disease (1)
- Chronic heart failure (1)
- Chronic stress (1)
- Clinical Genetics (1)
- Coffin-Lowry syndrome (1)
- Cognitive Therapy (1)
- Cognitive control (1)
- Cognitive decline (1)
- Corticobasal syndrome (1)
- Covid-19 (1)
- D-amino acid oxidase activator (1)
- DAT (1)
- DNA Methylation (1)
- DNA damage (1)
- DNA methyltransferases (1)
- DNMT3A (1)
- DRD2 (1)
- De-novo (1)
- Demyelination (1)
- Demyelinisierung (1)
- Diabetic polyneuropathy (1)
- Diagnosis prediction (1)
- Disease progression (1)
- Disease-modifying therapies (1)
- Disorders (1)
- Dorsolateral prefrontal cortex (1)
- Drosophila (1)
- Drosophila model (1)
- Drug development (1)
- Dynamic Causal Modeling (1)
- E3 ubiquitin ligase (1)
- EBM (1)
- Early infant catatonia (1)
- Early-onset (1)
- Enrichment analysis (1)
- Epigenesis (1)
- Epigenetik (1)
- Europe (1)
- Event-related potentials (1)
- Expression (1)
- FNIRS (1)
- Familial/sporadic concept (1)
- Female (1)
- Frühkindliche Katatonie (1)
- Frühkindlicher Hirnschaden (1)
- GABA (1)
- GABBR1 (1)
- GAD1 (1)
- GAP (1)
- GFAP (1)
- GHQ-28 (1)
- GLUT3 (1)
- GPCRs (1)
- GRN (1)
- GWAS (1)
- Gemeindepsychiatrie (1)
- Generic questionnaire (1)
- Genetic (1)
- Genetik (1)
- Genotype (1)
- Glial fibrillary acidic protein (1)
- Granular layer (1)
- HAND (1)
- HDBSCAN (1)
- HIV (1)
- Hirninfarkt (1)
- Htr1a (1)
- Htr2a (1)
- Htr2c (1)
- Human CDH13 (1)
- Human behaviour (1)
- Human brain (1)
- Human entorhinal area (1)
- Humans (1)
- Huntington's disease . Human cerebral cortex (1)
- Hurst Exponent (1)
- Hyperintense Marklagerläsionen (1)
- Hyperintense white matter lesions (1)
- ICT (1)
- IMpACT (1)
- Iife threatening catatonic syndrome (1)
- Induced Pluripotent Stem Cells (1)
- Inflammatio (1)
- Insensitivity (1)
- Insulin Degrading Enzyme (1)
- Interferon-alpha (1)
- Japanese population (1)
- KFZA (1)
- Klinische Psychiatrie (1)
- Knock-out mice (1)
- Kontusion (1)
- LPHN3 (1)
- LPS (1)
- Latency (1)
- Lateralitity (1)
- Laterality (1)
- Leonhard cIassification (1)
- Leukoaraiose (1)
- Leukoaraiosis (1)
- Long-term depression (1)
- MAPK signaling (1)
- MCPH1 (1)
- MRT (1)
- Maintenance treatment (1)
- Major depression (1)
- Malignant neuroleptic syndrome (1)
- Malignes neuroleptisches Syndrom (1)
- Mania (1)
- Maternal infections (1)
- Measurement invariance (1)
- Media (1)
- Medicine (1)
- Memory dysfunction (1)
- Messenger-RNA (1)
- MiMIC (1)
- Model (1)
- Molecular biology (1)
- Molecular-genetics (1)
- Monoamine Oxidase/genetics (1)
- Monopolar depression (1)
- Mood disorders (1)
- Motor nerve biopsy (1)
- Mouse-brain (1)
- N170 (1)
- NCAM1 (1)
- NIRS (1)
- NPSR1 (1)
- NPU (1)
- NSSI (1)
- Neostriatum (1)
- Nerve fibers (1)
- Nesplora Aquarium (1)
- Neurologie (1)
- Neuronal plasticity (1)
- Neurone number (1)
- Neurons (1)
- Neuropathy (1)
- Neuroprotection (1)
- Neuropsychiatrie (1)
- Neurotrophic factors (1)
- Nissl stain (1)
- Npy (1)
- Npyr1 (1)
- Npyr2 (1)
- Nucleus accumbens (1)
- Ontogeny (1)
- Opioid receptor (1)
- P100 (1)
- P300 topography (1)
- PET-1 (1)
- PTSD (1)
- PYY3-36 (1)
- Panic Disorder/genetics (1)
- Panic Disorder/therapy (1)
- Parallel fiber synapses (1)
- Parkinson disease (1)
- Parkinsonism (1)
- Perinatal Asphyxia (1)
- Perinatal brain damage (1)
- Periventricular hyperintensities (1)
- Periventrikuläre Hyperintensitäten (1)
- Personalized medicine (1)
- Pharmakovigilanz (1)
- Photon migration (1)
- Physiological functions (1)
- Pigmentarchitectonics (1)
- Polarity index (1)
- Poststroke depression (1)
- Predominant polarity (1)
- Pregnancy (1)
- Prognostic markers (1)
- Propagation (1)
- Prosaccade (1)
- Psychisch Kranker (1)
- Psychologie (1)
- Psychopathology (1)
- Psychopharmakotherapie (1)
- Purkinje-Zellen (1)
- Qb-Test (1)
- Qualitätssicherung (1)
- Quantitative Anatomie (1)
- Quetiapine (1)
- RIM1α (1)
- RNA expression (1)
- RSK (1)
- RSK2 (1)
- RTMS (1)
- Rat-brain (1)
- Regional differences (1)
- Restraint stress (1)
- Rotary EXcitation (REX) (1)
- Roux-en-Y gastric bypass surgery (1)
- S-HT (1)
- S6KII RSK (1)
- SARS-CoV-2 (1)
- SARS-CoV-2 brain disorders (1)
- SCF (1)
- SERT (1)
- SKP1 (1)
- SLC2A3 (1)
- SLC6A4 (1)
- STORM (1)
- SV pool (1)
- Saccadic eye-movements (1)
- Scattering (1)
- Schwangerschaft (1)
- Schwangerschaftsinfektion (1)
- Secondary affective disorder (1)
- Selective attention (1)
- Senescent rat (1)
- Senile rat (1)
- Senile rats (1)
- Sequence Analysis (1)
- Serotonin (1)
- Serotonin transporter (1)
- Serotonin transporter polymorphism (1)
- Sert-deficient mice (1)
- Skin biopsy (1)
- Sonic hedgehog (1)
- Spectroscopy fnirs (1)
- Spinal nerves (1)
- Spines (1)
- Stimuli (1)
- Strain differences (1)
- Striatum (1)
- Sub-saharan Africa (1)
- Support vector machine (1)
- Surrogate endpoints (1)
- System (1)
- Systematic review (1)
- T-cadherin (1)
- Task-performance (1)
- Thalamic nuclei (1)
- Therapeutisches Drug Monitoring (1)
- Tissues (1)
- Toll-like receptor 4 (TLR4) (1)
- Transgenic mice (1)
- Transporter (1)
- Triple in situ hybridization (1)
- Tryptophan hydroxylase-2 (Tph2) (1)
- UPPS (1)
- Ultrastructure (1)
- Unc-13 (1)
- VAL66MET polymorphism (1)
- VBM (1)
- Vergence (1)
- Voluntary control (1)
- Western diet (1)
- Working memory (1)
- Xenopus laevis oocytes (1)
- accidents (1)
- acetylcholine (1)
- acid sphingomyelinase (1)
- acoustic startle (1)
- acute brain slices (1)
- acute mania (1)
- adult attention deficit/hyperactivity disorder (1)
- adult attention deficit/hyperactivity disorder (adult ADHD) (1)
- adult treatment (1)
- adverse drug reactions (1)
- advisory groups (1)
- affective disorders (1)
- affective state (1)
- age stereotypes (1)
- aggressiveness (1)
- aging and cell death (1)
- aging brain (1)
- aging-related disease (1)
- agreeableness (1)
- akut lebensbedrohlich katatones Syndrom (1)
- allostatic load (1)
- amino acid analysis (1)
- amygdala response (1)
- analysis of variance (1)
- animal performance (1)
- anterior insula (1)
- anti-depressive treatment (1)
- anticipation (1)
- anticipatory anxiety (1)
- antidepressive agents (1)
- anxiety like (1)
- anxiety-like behavior (1)
- anxious depression (1)
- aphasia (1)
- apolipoprotein-E4 (1)
- apoptosis (1)
- assay (1)
- assessment of cognitive disorders/dementia (1)
- astrocytes (1)
- atlas‐based volumetry (1)
- atopic dermatitis (1)
- attention (1)
- attention deficit hyperactivity disorder (1)
- attention deficit/hyperactivity disorder (1)
- attention-deficit/hyperactivity disorder (ADHD) (1)
- attentional bias (1)
- auditory cortex (1)
- autism (1)
- autism spectrum disorder (1)
- autism-like behavior (1)
- autoinhibition (1)
- awareness (1)
- axonal transport (1)
- basal ganglia (1)
- behavioral activation system (1)
- beside test (1)
- biased signaling (1)
- bipolar disorders (1)
- blood biomarker (1)
- bold (1)
- bold activity (1)
- brain activation (1)
- brain bank (1)
- brain derived neurotrophic factor (1)
- brain development (1)
- brain disorders (1)
- brain pathology (1)
- brain stem (1)
- brain stimulation (1)
- brain-regions (1)
- breast cancer (1)
- burden (1)
- cadherins (1)
- caffeine-induced anxiety (1)
- cancer (1)
- candidate gene (1)
- capacity (1)
- capecitabine (1)
- cardiac sympathetic nerve system (1)
- cardiology (1)
- cardiorespiratory centre (1)
- cardiovascular arousal (1)
- case fatality rates (1)
- cell membranes (1)
- cell proliferation (1)
- cells (1)
- ceramides (1)
- cerebellar ataxia (1)
- cerebellar atrophy (1)
- cerebral artery occlusion (1)
- cerebrospina (1)
- child development (1)
- child memory (1)
- childhood maltreatment (1)
- cholinergic neurons (1)
- chromosome 12 (1)
- chronic distress (1)
- chronic stress (1)
- classical conditioning (1)
- classification (1)
- clinical diagnosis (1)
- clinical practice guideline (1)
- clinical trial (1)
- cluster analysis (1)
- coexpression (1)
- cognitive bias (1)
- cognitive control (1)
- cognitive decline (1)
- cognitive deficits (1)
- cognitive dysfunction (1)
- cognitive neuropsychology in dementia (1)
- cognitive-behavioral therapy (1)
- cognitive-behavioural psychotherapy (1)
- cohort studies (1)
- community sample (1)
- comparative anatomy (1)
- complementary alternative medicine (1)
- complex interventions (1)
- comprehensive psychosomatic assessment (1)
- computer-assisted instruction (1)
- congenital heart-deffects (1)
- contextual fear conditioning (1)
- continuous performance test (1)
- control strain (1)
- coping style (1)
- coping with challenge (1)
- copy number variants (1)
- copy number variation (1)
- copy-number variation (1)
- coronavirus (1)
- cortex (1)
- corticotropin releasing factor (1)
- cortisol (1)
- course (1)
- cross-sectional studies (1)
- cross-sectional study (1)
- crystal structure (1)
- cycloid psychoses (1)
- cycloid psychosis (1)
- cytoarchitectonic maps (1)
- cytoarchitectonics (1)
- cytome biomarkers (1)
- damage (1)
- data mining (1)
- de-novo methylation (1)
- deaths (1)
- decision making (1)
- defensive reactivity (1)
- defensive system reactivity (1)
- deficient mice (1)
- deficit (1)
- deficit hyperactivity disorder (1)
- dehydrogenases (1)
- delay (1)
- dementia with Lewy bodies (1)
- depressive disorder (1)
- development (1)
- developmental delay (1)
- dexamethasone (1)
- diagnosis (1)
- diagnostic medicine (1)
- dictator game (1)
- diet (1)
- differentiation (1)
- digital phenotyping (1)
- dimensions (1)
- disability (1)
- discrimination training (1)
- disease modelling (1)
- disease-modifying therapies (1)
- dopaminergics (1)
- dorsal raphe nucleus (1)
- drift-diffusion modeling (1)
- drug development (1)
- drug-addiction (1)
- dual guidance (1)
- e-learning (1)
- early diagnosis (1)
- early intervention (1)
- early-life stress (1)
- early-onset predictors (1)
- ecological momentary assessment (1)
- ectodomain cleavage (1)
- egoism (1)
- elderly (1)
- electrode recording (1)
- electroeneephalography (1)
- electron tomography (1)
- embryos (1)
- emotion regulation (1)
- emotional behavior (1)
- emotional experience (1)
- emotional influence (1)
- emotional information (1)
- emotions (1)
- encephalitis lethargica (1)
- endocannabinoids (1)
- endogenous psychoses (1)
- endophenotype (1)
- energy expenditure (1)
- energy metabolism (1)
- entorhinal cortex (1)
- environment (1)
- epigenetics in the nervous system (1)
- epigenomics (1)
- event-related fMRI (1)
- evoked potentials (1)
- executive function training (1)
- executive functions (1)
- eyes (1)
- facial affect (1)
- facial expression (1)
- factor expression (1)
- famiIiaI ·sporadic concept (1)
- familial-sporadic concept (1)
- families (1)
- family (1)
- family caregivers (1)
- fatigue (1)
- fear expression (1)
- fear learning (1)
- fear memory consolidation (1)
- fear-relevant training (1)
- febrile seizures (1)
- feedback (1)
- female (1)
- ferroptosis (1)
- fetal preconditioning (1)
- fibromyalgia syndrome (1)
- fluid (1)
- follow-up (1)
- freezing (1)
- frontal cortex (1)
- frontotemporal lobar degeneration (1)
- fumarate (1)
- functional near-infrared spectroscopy (1)
- fusiform gyrus (1)
- gender (1)
- gender differences (1)
- gene ADGRL3 (1)
- gene × gene interaction (1)
- gene-by-environment interaction (1)
- gene-environment interaction (1)
- geneexpression (1)
- genetic interaction (1)
- genetic loci (1)
- genetic phenotypes (1)
- genetic risk factor (1)
- genetic variants (1)
- genetic variation (1)
- genetics memory (1)
- genomic response (1)
- genotype (1)
- genotype-phenotype patterns (1)
- glia (1)
- glial fibrillary acidic protein (1)
- glucocorticoids (1)
- glucose (1)
- glucose tolerance (1)
- glutamate (1)
- glutamate receptor (1)
- glycine (1)
- glycine receptor (1)
- glycine receptor beta subunit (1)
- glycogen synthase kinase-3β (1)
- granule cells (1)
- granules (1)
- growth factor (1)
- hand (1)
- haplotypes (1)
- head (1)
- health care (1)
- heart failure (1)
- heart rate variability (1)
- heat shock protein Hsc-70 (1)
- hepcidin (1)
- heritability (1)
- heterosis (1)
- heterozygote (1)
- hierarchical drift-diffusion modeling (1)
- high-pressure freezing (1)
- hippocampal formation (1)
- hippocampal mossy fiber bouton (1)
- hippocampal neurogenesis (1)
- hippocampal volume (1)
- histamine (1)
- hospital (1)
- hospitalisation (1)
- human brain (1)
- human induced pluripotent stem cell (hiPSC) (1)
- human orbitofrontal cortex (1)
- hyperactivity (1)
- hypothalamic gene expression (1)
- iPSC (1)
- iPSCs (1)
- iiron transporter (1)
- imaging mass spectrometry (1)
- immediate-early gene (1)
- immunology (1)
- impact (1)
- impairments (1)
- impulse control disorders (1)
- impulsivity (1)
- in vivo (1)
- incentives (1)
- incidence (1)
- indans (1)
- individual differences (1)
- individual quality of life (1)
- induced pluripotent stem cells (1)
- inferior parietal lobule (1)
- inflammatory cytokines (1)
- inflammatory diseases (1)
- informal caregiving (1)
- insulin resistance (1)
- insulin-like growth factor 1 receptor (1)
- intelligibility (1)
- intensity of attention (1)
- interleukin 6 (1)
- intermediate phenotype approach (1)
- interstitial duplications (1)
- intervention study (1)
- iron in parkinsonism (1)
- iron model (1)
- iron pathology (1)
- ischemic brain injury (1)
- ischemic stroke (1)
- joint action (1)
- judgement bias (1)
- knock-out mice (1)
- laboratory and online studies (1)
- laboratory environment (1)
- lacking (1)
- learning and memory (1)
- learning curves (1)
- length of stay (1)
- lethai catatonia (1)
- levodopa (1)
- life (1)
- linkage (1)
- liraglutide (1)
- lithium (1)
- localization microscopy (1)
- loci (1)
- locomotor activity (1)
- loneliness (1)
- longitudinal magnetic resonance imaging (1)
- machine learning (1)
- magnetic-resonance-spectroscopy (1)
- major depressive disorder (MDD) (1)
- mammalian development (1)
- management (1)
- mapping susceptibility genes (1)
- massively multiplayer online role playing games (1)
- maternal (1)
- maternal infection (1)
- maternal separation (1)
- matrix metalloproteinase (1)
- maturation (1)
- mechanismofaction (1)
- mechanisms (1)
- medial prefrontal cortex (mPFC) (1)
- medial temporal lobe (1)
- median and dorsal raphe (1)
- medical Education (1)
- medical education (1)
- medicine (1)
- membrane potential (1)
- membrane proteins (1)
- memory consolidation and extinction (1)
- memory deficits (1)
- memory formation (1)
- mental arithmetic (1)
- mental illness (1)
- messenger RNA (1)
- metaanalysis (1)
- metagenomics (1)
- methylphenidate (1)
- microarray (1)
- microarrays (1)
- microcephalin 1 (1)
- microdeletion (1)
- midbrain (1)
- middle aged (1)
- migraine (1)
- mild cognitive impairment (1)
- mind-body intervention (1)
- mismatch (1)
- mitochondria (1)
- mitochondrial pathology (1)
- mitochondrial translation (1)
- mitochondrial transport (1)
- mobile crowdsensing (1)
- mobile health (1)
- moclobemide (1)
- modulation (1)
- molecular genetics (1)
- monetary incentive delay task (1)
- monoamine oxidase (1)
- monoamine oxidase A (1)
- monoamine oxidase inhibitors (1)
- monoamine transporters (1)
- monopolar depressive disorders (1)
- monopolare endogene Depression (1)
- mood disorder (1)
- mood disorders (1)
- morality (1)
- mothers (1)
- motivation (1)
- motoneuron (1)
- mouse (1)
- movement disorders (1)
- mrsk2 KO mouse (1)
- multicenter (1)
- multimedia, (1)
- multiple myeloma (1)
- multiple sclerosis (1)
- multiple system atrophy (1)
- multi‑center cohort study (1)
- music performance anxiety (1)
- myocardial sympathetic innervation imaging (1)
- nanoarchitecture (1)
- neonatal brain (1)
- neonatal hypoxia (1)
- nervour system (1)
- nervous system (1)
- neural activity (1)
- neural fear network activation (1)
- neural mechanisms (1)
- neural stem cells (1)
- neuregulin-1 (1)
- neurite outgrowth (1)
- neurobiology (1)
- neurodevelopmental disorders (1)
- neurodevelopmental disorders / genetics (1)
- neurofilament light chain (1)
- neurogenesis (1)
- neuroinvasion (1)
- neurological disorders (1)
- neurological symptoms/disorders (1)
- neurology (1)
- neuromelanin granules (1)
- neuromuscular junction (1)
- neuron (1)
- neuron navigator 3 (1)
- neuronal dendrites (1)
- neuronal differentiation (1)
- neuronal dysfunction (1)
- neuronal plasticity (1)
- neurons (1)
- neuropathic pain (1)
- neuroplasticity (1)
- neuropsychiatry (1)
- neurorehabilitation (1)
- neuroscience (1)
- neurothrophic factor (1)
- neurotrophic factor (1)
- neurotrophic factor gene (1)
- nitricoxidesynthase (1)
- non-suicidal self-injury (1)
- nucleus (1)
- nucleus accumbens (1)
- nurses (1)
- objective structured clinical examination (1)
- observer agreement (1)
- obstetric complications (1)
- of-the-literature (1)
- older employees (1)
- onset (1)
- optic ataxia (1)
- oral anticancer drugs (1)
- organische affektive Störungen (1)
- oscillating biomagnetic fields (1)
- oxygen consumption (1)
- parathyroid hormone 1 receptor (1)
- parent training (1)
- parental origin (1)
- parietal lobe (1)
- parkinson’s disease (1)
- paternal (1)
- patient-doctor-relationship (1)
- pediatrics (1)
- people (1)
- perception (1)
- periodic catatonia (1)
- peripheral-blood lymphocytes (1)
- perniziöse Katatonie (1)
- persistent ADHD (1)
- personality (1)
- personalized medicine (1)
- perspectives (1)
- pharmacogenetics (1)
- pharmacotherapy (1)
- phasic threat responding (1)
- phenelzine (1)
- phobia (1)
- phosphorylated tau protein (1)
- physical health (1)
- pigment (1)
- polymorphism (1)
- polymorphisms (1)
- population (1)
- population-based studies (1)
- positive affect (1)
- positive interneurons (1)
- positron-emission-tomography (1)
- postencephalitic parkinsonism (1)
- posterior cortical atrophy (1)
- posterior parietal cortex (1)
- posteroinferior occipitotemporal gyrus (1)
- postmortem (1)
- postmortem studies (1)
- postnatal depression (1)
- posttraumatic-stress-disorder (1)
- precision medicine (1)
- predict (1)
- prefrontal activity (1)
- pregnancy anxiety (1)
- prenatal stress (1)
- prepulse inhibition (1)
- presynaptic (1)
- presynaptic homeostasis (1)
- prevalence (1)
- preventive strategies (1)
- primary care (1)
- primary progressive aphasia (1)
- primary response genes (1)
- process evaluation (1)
- processing bias (1)
- processing speed (1)
- progressive muscle relaxation (1)
- proliferation (1)
- promoter region (1)
- prophylactic lithium (1)
- prosociality (1)
- protein (1)
- protein aggregation (1)
- protein kinase (1)
- psychiatric-hospitalization (1)
- psycho-geriatrics (1)
- psychological distress (1)
- psychological stress (1)
- psychology (1)
- psychooncology (1)
- psychopharmacotherapy (1)
- psychosocial stress (1)
- psychosocial workplace risk assessment (1)
- psychotic experiences (1)
- psychotropic medication (1)
- psychotropic medications (1)
- public health (1)
- punishment (1)
- qualitative approaches (1)
- quality assurance (1)
- quality of live (1)
- quantitative anatomy (1)
- randomized-controlled trial (1)
- rare diseases (1)
- rare mendelian disorders (1)
- rasagiline (1)
- rat brain (1)
- rating scale (1)
- real-life interaction (1)
- realist evaluation (1)
- receptor gene polymorphism (1)
- receptors (1)
- recognition memory (1)
- reconsolidation (1)
- recurrent Tako-Tsubo cardiomyopathy (1)
- regenerative research (1)
- religiosity (1)
- remitted/acute phase (1)
- renal function (1)
- repair (1)
- repulsive guidance molecule A (1)
- research errors (1)
- resting-state fMRI (1)
- reward (1)
- reward deficiency syndrome (1)
- right inferior frontalgyrus (1)
- risk SNP rs1397547 (1)
- risk genes (1)
- risperidone (1)
- rule discovery (1)
- safety (1)
- safety behavior (1)
- sample size calculation (1)
- sections (1)
- selegiline (1)
- self-employed (1)
- sequence variations (1)
- serotonergic system (1)
- serotonin deficiency (1)
- serotonin receptors (1)
- serotonin transporter deficient mice (1)
- serotonin(1A) receptor (1)
- serotonin-specific neurons (1)
- serum concentration (1)
- sex (1)
- short-term methylphenidate brain (1)
- short-term-memory (1)
- sialic acid (1)
- sialyltransferase (1)
- signal transduction pathway (1)
- simulation (1)
- single subject (1)
- skin conductance (1)
- skin conduction response (1)
- small business (1)
- smoking cessation (1)
- social anxiety (1)
- social avoidance (1)
- social capital (1)
- social cognitive (1)
- social distancing (1)
- social experience (1)
- social interaction (1)
- social isolation (1)
- social motives (1)
- social neuroscience (1)
- spastic (1)
- spatial memory (1)
- spectrum disorder (1)
- spectrum disorders (1)
- sphingolipids (1)
- spider phobia (1)
- spontaneously hypertensive rat (1)
- sporadic Parkinson's disease (1)
- startle reaction (1)
- states (1)
- stem cells (1)
- stereology (1)
- strategies (1)
- streptozotocin (1)
- stress granules (1)
- stressful life events (1)
- stroop interference (1)
- subphenotypes (1)
- subsctraction (1)
- subsequent memory (1)
- supervisors (1)
- surrogate endpoints (1)
- survey (1)
- susceptibility (1)
- sustained fear (1)
- sustained threat responding (1)
- swim test (1)
- synapse (1)
- synapse formation (1)
- synaptic plasticity (1)
- synaptic transmission (1)
- synaptic ultrastructure (1)
- synaptosomes (1)
- systems (1)
- systems biology (1)
- tDCS (1)
- tandem mass spectrometry (1)
- target (1)
- targeted bisulfite sequencing (1)
- task complexity (1)
- task difficulty (1)
- tauopathy (1)
- teaching hospital (1)
- telomere length (1)
- temporal lobe epilepsy (1)
- theranostic markers (1)
- therapy (1)
- therapy response (1)
- threat-related stimuli (1)
- tolerability (1)
- tolerance (1)
- trail making test (1)
- transcranial magnetic stimulation (1)
- transcranial magnetic stimulation (TMS) (1)
- transient global ischemia (1)
- transmission (1)
- transporter gene SLC2A3 (1)
- tranylcypromine (1)
- treatment (1)
- treatment guidelines (1)
- treatment response (1)
- tryptophan hydroxylase 2 (1)
- tryptophan hydroxylase-2 (1)
- ubiquitination (1)
- ultra-high risk (1)
- ultrasound imaging (1)
- understaffed (1)
- unerwünschte Arzneimittelwirkungen (1)
- universal prevention (1)
- valence framing (1)
- validation (1)
- validity (1)
- ventromedial prefrontal cortex (1)
- verbal fluency task (1)
- verbal n-back (1)
- video-game (1)
- virtual patients (1)
- virtual reality exposure therapy (1)
- viruses (1)
- virus–iron interaction (1)
- vitamin D deficiency (1)
- volumetric MRI (1)
- von Economo (1)
- voxel-based morphometry (1)
- work-related stress (1)
- world of warcraft (1)
- yoga (1)
- younger employees (1)
- zykloide Psychose (1)
- ɑ-Synuclein and iron (1)
Institute
- Klinik und Poliklinik für Psychiatrie, Psychosomatik und Psychotherapie (248) (remove)
Sonstige beteiligte Institutionen
New innovative neuropsychological tests in attention deficit hyperactivity disorder ADHD have been proposed as objective measures for diagnosis and therapy. The current study aims to investigate two different commercial continuous performance tests (CPT) in a head-to-head comparison regarding their comparability and their link with clinical parameters. The CPTs were evaluated in a clinical sample of 29 adult patients presenting in an ADHD outpatient clinic. Correlational analyses were performed between neuropsychological data, clinical rating scales, and a personality-based measure. Though inattention was found to positively correlate between the two tests (r = 0.49, p = 0.01), no association with clinical measures and inattention was found for both tests. While hyperactivity did not correlate between both tests, current ADHD symptoms were positively associated with Nesplora Aquarium's motor activity (r = 0.52 to 0.61, p < 0.05) and the Qb-Test's hyperactivity (r = 0.52 to 0.71, p < 0.05). Conclusively, the overall comparability of the tests was limited and correlation with clinical parameters was low. While our study shows some interesting correlation between clinical symptoms and sub-scales of these tests, usage in clinical practice is not recommended.
Ablation of BRaf Impairs Neuronal Differentiation in the Postnatal Hippocampus and Cerebellum
(2013)
This study focuses on the role of the kinase BRaf in postnatal brain development. Mice expressing truncated, non-functional BRaf in neural stem cell-derived brain tissue demonstrate alterations in the cerebellum, with decreased sizes and fuzzy borders of the glomeruli in the granule cell layer. In addition we observed reduced numbers and misplaced ectopic Purkinje cells that showed an altered structure of their dendritic arborizations in the hippocampus, while the overall cornus ammonis architecture appeared to be unchanged. In male mice lacking BRaf in the hippocampus the size of the granule cell layer was normal at postnatal day 12 (P12) but diminished at P21, as compared to control littermates. This defect was caused by a reduced ability of dentate gyrus progenitor cells to differentiate into NeuN positive granule cell neurons. In vitro cell culture of P0/P1 hippocampal cells revealed that BRaf deficient cells were impaired in their ability to form microtubule-associated protein 2 positive neurons. Together with the alterations in behaviour, such as autoaggression and loss of balance fitness, these observations indicate that in the absence of BRaf all neuronal cellular structures develop, but neuronal circuits in the cerebellum and hippocampus are partially disturbed besides impaired neuronal generation in both structures.
Sustained anticipatory anxiety is central to Generalized Anxiety Disorder (GAD). During anticipatory anxiety, phasic threat responding appears to be mediated by the amygdala, while sustained threat responding seems related to the bed nucleus of the stria terminalis (BNST). Although sustained anticipatory anxiety in GAD patients was proposed to be associated with BNST activity alterations, firm evidence is lacking. We aimed to explore temporal characteristics of BNST and amygdala activity during threat anticipation in GAD patients. Nineteen GAD patients and nineteen healthy controls (HC) underwent functional magnetic resonance imaging (fMRI) during a temporally unpredictable threat anticipation paradigm. We defined phasic and a systematic variation of sustained response models for blood oxygen level-dependent responses during threat anticipation, to disentangle temporally dissociable involvement of the BNST and the amygdala. GAD patients relative to HC responded with increased phasic amygdala activity to onset of threat anticipation and with elevated sustained BNST activity that was delayed relative to the onset of threat anticipation. Both the amygdala and the BNST displayed altered responses during threat anticipation in GAD patients, albeit with different time courses. The results for the BNST activation hint towards its role in sustained threat responding, and contribute to a deeper understanding of pathological sustained anticipatory anxiety in GAD.
The transcription factor Lmx1b is essential for the differentiation and survival of central serotonergic (5-HTergic) neurons during embryonic development. However, the role of Lmx1b in adult 5-HTergic neurons is unknown. We used an inducible Cre-LoxP system to selectively inactivate Lmx1b expression in the raphe nuclei of adult mice. Pet1-CreER(T2) mice were generated and crossed with Lmx1b(flox/flox) mice to obtain Pet1-CreER(T2); Lmx1b(flox/flox) mice (which termed as Lmx1b iCKO). After administration of tamoxifen, the level of 5-HT in the brain of Lmx1b iCKO mice was reduced to 60% of that in control mice, and the expression of tryptophan hydroxylase 2 (Tph2), serotonin transporter (Sert) and vesicular monoamine transporter 2 (Vmat2) was greatly down-regulated. On the other hand, the expression of dopamine and norepinephrine as well as aromatic L-amino acid decarboxylase (Aadc) and Pet1 was unchanged. Our results reveal that Lmx1b is required for the biosynthesis of 5-HT in adult mouse brain, and it may be involved in maintaining normal functions of central 5-HTergic neurons by regulating the expression of Tph2, Sert and Vmat2.
The etiology of emotion-related disorders such as anxiety or affective disorders is considered to be complex with an interaction of biological and environmental factors. Particular evidence has accumulated for alterations in the dopaminergic and noradrenergic system - partly conferred by catechol-O-methyltransferase (COMT) gene variation - for the adenosinergic system as well as for early life trauma to constitute risk factors for those conditions. Applying a multi-level approach, in a sample of 95 healthy adults, we investigated effects of the functional COMT Val158Met polymorphism, caffeine as an adenosine A2A receptor antagonist (300 mg in a placebo-controlled intervention design) and childhood maltreatment (CTQ) as well as their interaction on the affect-modulated startle response as a neurobiologically founded defensive reflex potentially related to fear- and distress-related disorders. COMT val/val genotype significantly increased startle magnitude in response to unpleasant stimuli, while met/met homozygotes showed a blunted startle response to aversive pictures. Furthermore, significant gene-environment interaction of COMT Val158Met genotype with CTQ was discerned with more maltreatment being associated with higher startle potentiation in val/val subjects but not in met carriers. No main effect of or interaction effects with caffeine were observed. Results indicate a main as well as a GxE effect of the COMT Val158Met variant and childhood maltreatment on the affect-modulated startle reflex, supporting a complex pathogenetic model of the affect-modulated startle reflex as a basic neurobiological defensive reflex potentially related to anxiety and affective disorders.
Aim
This study aimed to identify and compare age stereotypes of registered nurses and supervisors in clinical inpatient settings.
Design
Generic qualitative study using half‐standardized interviews.
Method
Nineteen face‐to‐face interviews and five focus groups (N = 50) were conducted with nurses of varying levels at a hospital of maximum medical care in Germany between August and November 2018 and were subjected to structured qualitative content analysis.
Results
Reflecting the ageing process and cooperation in mixed‐age teams, nursing staff and supervisors defined similar age stereotypes towards older and younger nurses reminiscent of common generational labels ‘Baby Boomers’ and Generations X. Their evaluation created an inconsistent and contradictory pattern differing to the respective work context and goals. Age stereotypes were described as both potentially beneficial and detrimental for the individual and the cooperation in the team. If a successfully implemented diversity management focuses age stereotypes, negative assumptions can be reduced and cooperation in mixed‐age teams can be considered beneficial.
Conclusion
Diversity management as measures against age stereotypes and for mutual acceptance and understanding should include staff from various hierarchical levels of the inpatient setting.
Loss of function mutations in the rsk2 gene cause Coffin-Lowry syndrome (CLS), which is associated with multiple symptoms including severe mental disabilities. Despite the characterization of ribosomal S6 kinase 2 (RSK2) as a protein kinase acting as a downstream effector of the well characterized ERK MAP-kinase signaling pathway, it turns out to be a challenging task to link RSK2 to specific neuronal processes dysregulated in case of mutation. Animal models such as mouse and Drosophila combine advanced genetic manipulation tools with in vivo imaging techniques, high-resolution connectome analysis and a variety of behavioral assays, thereby allowing for an in-depth analysis for gene functions in the nervous system. Although modeling mental disability in animal systems has limitations because of the complexity of phenotypes, the influence of genetic variation and species-specific characteristics at the neural circuit and behavioral level, some common aspects of RSK2 function in the nervous system have emerged, which will be presented. Only with this knowledge our understanding of the pathophysiology of CLS can be improved, which might open the door for development of potential intervention strategies.
Background:
Antidepressant drugs (ADs) have been shown to activate BDNF (brain-derived neurotrophic factor) receptor TrkB in the rodent brain but the mechanism underlying this phenomenon remains unclear. ADs act as monoamine reuptake inhibitors and after prolonged treatments regulate brain bdnf mRNA levels indicating that monoamine-BDNF signaling regulate AD-induced TrkB activation in vivo. However, recent findings demonstrate that Trk receptors can be transactivated independently of their neurotrophin ligands.
Methodology:
In this study we examined the role of BDNF, TrkB kinase activity and monoamine reuptake in the AD-induced TrkB activation in vivo and in vitro by employing several transgenic mouse models, cultured neurons and TrkB-expressing cell lines.
Principal Findings:
Using a chemical-genetic TrkB(F616A) mutant and TrkB overexpressing mice, we demonstrate that ADs specifically activate both the maturely and immaturely glycosylated forms of TrkB receptors in the brain in a TrkB kinase dependent manner. However, the tricyclic AD imipramine readily induced the phosphorylation of TrkB receptors in conditional bdnf(-/-) knock-out mice (132.4+/-8.5% of control; P = 0.01), indicating that BDNF is not required for the TrkB activation. Moreover, using serotonin transporter (SERT) deficient mice and chemical lesions of monoaminergic neurons we show that neither a functional SERT nor monoamines are required for the TrkB phosphorylation response induced by the serotonin selective reuptake inhibitors fluoxetine or citalopram, or norepinephrine selective reuptake inhibitor reboxetine. However, neither ADs nor monoamine transmitters activated TrkB in cultured neurons or cell lines expressing TrkB receptors, arguing that ADs do not directly bind to TrkB.
Conclusions:
The present findings suggest that ADs transactivate brain TrkB receptors independently of BDNF and monoamine reuptake blockade and emphasize the need of an intact tissue context for the ability of ADs to induce TrkB activity in brain.
A GWAS study recently demonstrated single nucleotide polymorphisms (SNPs) in the human GLRB gene of individuals with a prevalence for agoraphobia. GLRB encodes the glycine receptor (GlyRs) β subunit. The identified SNPs are localized within the gene flanking regions (3′ and 5′ UTRs) and intronic regions. It was suggested that these nucleotide polymorphisms modify GlyRs expression and phenotypic behavior in humans contributing to an anxiety phenotype as a mild form of hyperekplexia. Hyperekplexia is a human neuromotor disorder with massive startle phenotypes due to mutations in genes encoding GlyRs subunits. GLRA1 mutations have been more commonly observed than GLRB mutations. If an anxiety phenotype contributes to the hyperekplexia disease pattern has not been investigated yet. Here, we compared two mouse models harboring either a mutation in the murine Glra1 or Glrb gene with regard to anxiety and startle phenotypes. Homozygous spasmodic animals carrying a Glra1 point mutation (alanine 52 to serine) displayed abnormally enhanced startle responses. Moreover, spasmodic mice exhibited significant changes in fear-related behaviors (freezing, rearing and time spent on back) analyzed during the startle paradigm, even in a neutral context. Spastic mice exhibit reduced expression levels of the full-length GlyRs β subunit due to aberrant splicing of the Glrb gene. Heterozygous animals appear normal without an obvious behavioral phenotype and thus might reflect the human situation analyzed in the GWAS study on agoraphobia and startle. In contrast to spasmodic mice, heterozygous spastic animals revealed no startle phenotype in a neutral as well as a conditioning context. Other mechanisms such as a modulatory function of the GlyRs β subunit within glycinergic circuits in neuronal networks important for fear and fear-related behavior may exist. Possibly, in human additional changes in fear and fear-related circuits either due to gene-gene interactions e.g., with GLRA1 genes or epigenetic factors are necessary to create the agoraphobia and in particular the startle phenotype.