Refine
Is part of the Bibliography
- yes (161)
Year of publication
Document Type
- Doctoral Thesis (108)
- Journal article (51)
- Preprint (1)
- Report (1)
Keywords
- Maus (5)
- Myc (4)
- Plasmozytom (4)
- Multiple Sklerose (3)
- Multiples Myelom (3)
- Schlaganfall (3)
- T-Lymphozyt (3)
- infection (3)
- stroke (3)
- Adipositas (2)
- Anorexia nervosa (2)
- Antagonist (2)
- Apobec (2)
- COVID-19 (2)
- DNA (2)
- Depression (2)
- Entzündung (2)
- Expression (2)
- Fluoreszenz (2)
- Genetik (2)
- Handgelenk (2)
- Hemmstoff (2)
- Herzfrequenzvariabilität (2)
- Heubacillus (2)
- Mausmodell (2)
- Mitose (2)
- NSCLC (2)
- Neisseria meningitidis (2)
- Niereninsuffizienz (2)
- RN18 (2)
- RNA (2)
- ROS (2)
- Schmerz (2)
- Speckle tracking (2)
- Stress (2)
- TP53 (2)
- Thrombozyt (2)
- Translation <Genetik> (2)
- Vif (2)
- colorectal cancer (2)
- depression (2)
- diagnosis (2)
- echocardiography (2)
- electrocardiography (2)
- epidemiology (2)
- grip force (2)
- microRNA (2)
- platelets (2)
- shRNA (2)
- strain rate (2)
- thrombo-inflammation (2)
- viability (2)
- 3-Ligament-Tenodese (1)
- 3D Mapping System (1)
- 3D mapping system (1)
- 3D-Kultur (1)
- 4-HNE (1)
- 5' UTR (1)
- ACC (1)
- ADHD (1)
- ADHS (1)
- AIDS (1)
- Abszission (1)
- Acceptance Evaluation (1)
- Adjuvans (1)
- Adrenocortical cancer (1)
- Adrenokortikales Karzinom (1)
- Advanced Glycation Endproducts (1)
- Advanced glycosylation end products (1)
- Affinity probe (1)
- Agonist (1)
- Aktivitätstest (1)
- Akzeptanz-Evaluation (1)
- Alternative Medizin (1)
- Alternativmedizin (1)
- Alzheimer`s disease (1)
- Alzheimerkrankheit (1)
- Angeborene Immunität (1)
- Angstsensitivität (1)
- Antigen CD4 (1)
- Antivirale Substanzen (1)
- Arthrodese (1)
- Arthroskopie (1)
- Aspergillus fumigatus (1)
- Atempumpe Sarkoidose (1)
- Aufwandsanalyse (1)
- Authoring Tools (1)
- Autoantikörper (1)
- Automatisierte Prüfungskorrektur (1)
- Autonome Balance (1)
- Autorensystem (1)
- BOLD signal (1)
- Bacillus subtilis (1)
- Bacterial infection (1)
- Bacteroides thetaiotaomicron (1)
- Bakterien (1)
- Bankart Läsion (1)
- Bauchspeicheldrüsenkrebs (1)
- Bericht (1)
- BioVaSc (1)
- Bioinformatik (1)
- Biologische Uhr (1)
- Biomarker (1)
- Biomedicine (1)
- Biomedizin (1)
- Blended Learning (1)
- Blut-Hirn-Schranke (1)
- Bordetella pertussis (1)
- Brain derived neurotorphic factor (1)
- Bronchialkarzinom (1)
- Brunelli (1)
- Bänderriss (1)
- C virus (1)
- C-tactile fibers (1)
- C. elegans (1)
- C5aR1-Antagonist (1)
- CARMO (1)
- CCL2 (1)
- CD8+ T cell differentiation (1)
- CD8+ T cells (1)
- CD8+ T-Zellen (1)
- CDK4 Inhibitor (1)
- CDK4 inhibitor (1)
- CIDP (1)
- CIP2A (1)
- CLAD (1)
- CRISPR-Cas (1)
- CRISPR/Cas-Methode (1)
- CRISPR/Cas9 (1)
- CRPS (1)
- CVT (1)
- Calcium (1)
- Candida albicans (1)
- Cas9 (1)
- CaseTrain (1)
- Caspr-1 (1)
- Chemische Synapsen (1)
- Children (1)
- Circadian (1)
- Collaborative Research Center (1)
- Colorectal cancer (1)
- Complement system (1)
- Complex Regional Pain Syndrome (1)
- Constant Score (1)
- Contactin-1 (1)
- Control centrality (1)
- Cost Analysis (1)
- Cruzi (1)
- Cytokine (1)
- DASH (1)
- DNA binding (1)
- DNA fragments (1)
- DNA sequencing (1)
- DNS (1)
- DPF3a (1)
- DUB Mutante (1)
- Democratic People's Republic of Korea (1)
- Dentalimplantat (1)
- Desmosom (1)
- Diabetes Mellitus (1)
- Diabetes mellitus (1)
- Diabetes mellitus / Typ 2 (1)
- Diabetes mellitus / Typ II (1)
- Dictyostelium discoideum (1)
- Dorsale Plikationsnaht (1)
- Drosophila (1)
- Drosophila melanogaster (1)
- Druckbelastung (1)
- Dual RNA-seq data analysis (1)
- EAE (1)
- ELISA (1)
- ESWT (1)
- Educational Measurement (I2.399) (1)
- Eigeninjektion / self injection (1)
- Electrospinning (1)
- Elektrokardiogramm (1)
- Embryonale Stammzellen (1)
- Encephalomyelitis (1)
- Endomyokardbiopsie (1)
- Endozytose (1)
- Entlassung (1)
- Epidemiologie (1)
- Epidermis (1)
- Epigenetik (1)
- Ethanol (1)
- Evidenz (1)
- Experimental Autoimmune Encephalomyelitis (EAE) (1)
- Experimental Biomedicine (1)
- Experimentelle Autoimmune Enzephalomyelitis (EAE) (1)
- Experimentelle Tumortherapie (1)
- F0 stability (1)
- FITT-STEMI-Studie (1)
- FOSL1 (1)
- Fabry disease (1)
- Faktor (1)
- Fettsucht (1)
- Fingergelenk (1)
- Fingergelenksversteifung (1)
- Fluorescence microscopy (1)
- Fluoreszenzmikroskopie (1)
- Fluoxetin (1)
- Foxp3+CD4+ regulatory T cell (1)
- GABA (1)
- GLA mutation (1)
- Gallensäuren (1)
- Gehhilfe (1)
- Gen-Knockout (1)
- Genetic regulatory networks (1)
- Genetics (1)
- Genexpression (1)
- Genome (1)
- Genregulation (1)
- Gephyrin (1)
- Glia (1)
- Glucose metabolism (1)
- Glucosyltransferase (1)
- Glukosemetabolismus (1)
- Glutathione (1)
- Gram-positive bacteria (1)
- Greifen (1)
- Griffkraft (1)
- Grundfrequenz (1)
- Guanylylcyclase (1)
- Guillain-Barré-Syndrom (1)
- HEY repressors (1)
- HNE (1)
- Hand (1)
- Handgelenksversteifung (1)
- Handkraft (1)
- Harnblasenkarzinom (1)
- HbA1c (1)
- Head-mounted Display (1)
- Hearing loss (1)
- Heart rate variability (1)
- Heilung (1)
- Hepatotoxizität (1)
- Herpes simplex (1)
- Herpes simplex Virus DUB C65A (1)
- Herpes simplex virus C65A (1)
- Herz (1)
- Herzinfarkt (1)
- Herzinfarktnetz (1)
- Herzinsuffizienz (1)
- Herzmuskelkrankheit (1)
- Hey-Gene (1)
- Hi-C (1)
- High energy, focused extracorporeal shock wave therapy (1)
- Hippokampus (1)
- Hirninfarkt (1)
- Histon-Demethylase UTX (1)
- Histone (1)
- Hochdosis-Glukokortikoidtherapie (1)
- Hochenergetische, fokussierte extrakorporale Stoßwellentherapie (1)
- Hormesis (1)
- Host defense (1)
- Host-pathogen interaction (1)
- Human Physiome (1)
- Hydrocortison (1)
- Hydrogen-peroxide (1)
- Hydroxymethyluracil (1)
- Hyperalgesie (1)
- Hypertonie (1)
- Hypoparathyreoidismus (1)
- Hypothalamus (1)
- Hämatopoese (1)
- Hörverlust (1)
- ICD (1)
- ICD-10 (1)
- ISIS (1)
- IgG-Subklasse (1)
- Ileus (1)
- Immunglobulin G (1)
- Immunology (1)
- Immunsystem (1)
- In-vitro (1)
- Increased Body Weight (1)
- Infektion (1)
- Inflammation (1)
- Inflammatory pain (1)
- Inhibitor (1)
- Inhibitorische Synapse (1)
- Inhibitory synapse (1)
- Innate immunity (1)
- Instabilität (1)
- Instrumentelle Analytik (1)
- Insulinresistenz (1)
- Interferon (1)
- Interleukin 6 (1)
- Intervallzeitmessung (1)
- Inzidenz (1)
- Inzidenz <Medizin> (1)
- Jitter (1)
- Joubert syndrome (1)
- Jugend (1)
- Kapselshift (1)
- Kapsulodese (1)
- Kardiovaskuläre Komorbiditäten (1)
- Kardiovaskuläre Krankheit (1)
- Katatonie (1)
- Katayama fever (1)
- Katdiotoxizität (1)
- Kenya (1)
- Kernspintomographie (1)
- Kinder (1)
- Kinesiotape (1)
- Kleine GTP-bindende Proteine (1)
- Knochenmark (1)
- Knock-Out (1)
- Knorpel (1)
- Kollagen I-Scaffold zum Sehnenersatz (1)
- Kollagen I-Scaffolds (1)
- Komplement (1)
- Komplement C5a (1)
- Komplement C5a Rezeptor 1 (1)
- Komplikationen dentaler Implantate (1)
- Komplimentärmedizin (1)
- Kontrollierte klinische Studie (1)
- Kopforthesentherapie (1)
- Kraftmessung (1)
- Kraftverteilung (1)
- Körperliche Belastbarkeit (1)
- LASP-1 (1)
- LIN9 (1)
- LOH (1)
- Lactatdehydrogenase (1)
- Lactobacillus reuteri (1)
- Lagerungsplagiozephalus (1)
- Laufbandtraining (1)
- Lebertoxizität (1)
- Li Fraumeni Syndrom (1)
- Li Fraumeni syndrome (1)
- Ligand (1)
- Ligand-Rezeptor-Interaktion (1)
- Lymphknoten (1)
- Lymphotoxin (1)
- MATQ-seq (1)
- MAX (1)
- MLC (1)
- MLC1 (1)
- MMN (1)
- MR-Morphologie (1)
- MRI (1)
- MYC (1)
- MYCN (1)
- Machine learning (1)
- Magnetresonanztomographie (1)
- Makrophage (1)
- Makrophagen (1)
- Mansoni infection (1)
- Manugraphy-System (1)
- Maschinelles Lernen (1)
- Medulloblastom (1)
- Melanom (1)
- Membrane transporters (1)
- Membranlipide (1)
- Membrantransporter (1)
- Mena/VASP (1)
- Meningokokken-Sepsis (1)
- Mensch (1)
- Messenger RNA (1)
- Metabolism (1)
- Methohexital (1)
- Methylation (1)
- Mikroglia (1)
- Mittelkörper (1)
- Molekularbiologie (1)
- Monozyten (1)
- Moosfaserterminalen (1)
- Motivation (1)
- Muliples Myelom (1)
- Multiple Sclerosis (1)
- Multiple-Choice Examination (1)
- Multiple-Choice Prüfungen (1)
- Muster-ERG (1)
- Mutationen (1)
- Mutter-Kind-Maßnahme (1)
- Mutterkindkur (1)
- Mutterkindvorsorge (1)
- Myokard (1)
- Myokardinfarkt (1)
- Myokarditis (1)
- NNMT (1)
- NNMT activity assay (1)
- Nachuntersuchung (1)
- Nasenschleimhaut (1)
- Natriumoxamat (1)
- Navigation (1)
- Nebenniereninsuffizienz / adrenal insufficiency (1)
- Nebennierenkrise / adrenal crisis (1)
- Nebennierenrinde (1)
- Nebennierenrindeninsuffizienz (1)
- Nebennierenrindenkarzinom (1)
- Nervenstammzelle (1)
- Neurodegeneration (1)
- Neuroinflammation (1)
- Neurorehabilitation (1)
- Neurotizismus (1)
- Neutrophil granulocyte (1)
- Neutrophiler Granulozyt (1)
- Neutrophils (1)
- Nichtlineare Differentialgleichung (1)
- Nigeria (1)
- Nodo-Paranodopathie (1)
- Noonan-Syndrom (1)
- Notch-Signalweg (1)
- Nrf2 (1)
- Obesity (1)
- Omega-3-Fettsäuren (1)
- Onkologie (1)
- Operation (1)
- Optogenetics (1)
- Optogenetik (1)
- Orientia tsutsugamushi (1)
- Osseointegartion (1)
- Osseointegration (1)
- Outlier detection (1)
- OxPL (1)
- Oxford Shoulder Instability Score (1)
- Oxidative Stress (1)
- Oxidative stress (1)
- Oxidativer Stress (1)
- Oxidized phospholipids (1)
- Oxygen (1)
- PAF1c (1)
- PARROT (1)
- PDE3 (1)
- PKD1 (1)
- PP2A (1)
- PPI (1)
- PPQ (1)
- Palbociclib (1)
- Pam2Cys (1)
- Parasite (1)
- Patient Simulation (1)
- Pattern classification (1)
- Peptidsynthese (1)
- Phagozytose (1)
- Pharmakokinetik (1)
- Pharmakokinetik / pharmacokinetics (1)
- Pioglitazon (1)
- Polymorphismen (1)
- Polyneuropathie (1)
- Polyphenols (1)
- Primärelement (1)
- Primärprevention (1)
- Primärzellen (1)
- Problem Based Learning (1)
- Problembasiertes Lernen (1)
- Prognose (1)
- Proliferation (1)
- Propofol (1)
- Prostatakarzinom (1)
- Prostatakrebs (1)
- Protein Kinase D (1)
- Protein Kinase D 1 (1)
- Prädiktoren (1)
- Präzisionsmedizin (1)
- Pseudarthrose (1)
- Psychische Belastung (1)
- Psychische Gesundheit (1)
- Psychophysiologische Diagnostik (1)
- Pulmonale Hypertonie (1)
- R337H (1)
- RAL (1)
- RNA polymerase (1)
- RNA sequencing (RNA-Seq) (1)
- RNA structure (1)
- RNA virus (1)
- RNA-binding proteins (1)
- RNA-seq (1)
- RNS-Interferenz (1)
- Rachitis (1)
- Ranvier-Schnürring (1)
- Ratte (1)
- Raucher (1)
- RbdB (1)
- Redox environment (1)
- Rehabilitation (1)
- Rekanalisation Hirninfarkt (1)
- Reposition (1)
- Resilienz (1)
- Retrosepektiv (1)
- Rezidivluxationen (1)
- Rituximab (1)
- SABR (1)
- SARS-CoV-2 (1)
- SBRT (1)
- SGLT (1)
- SHIP-TREND (1)
- SIS-muc (1)
- SL-Bandnaht (1)
- SL-Bandruptur (1)
- STEMI (1)
- Salmonella enterica (1)
- Sarkoidose (1)
- Sauerstoffkonzentration (1)
- Schizophrenie (1)
- Schlaf (1)
- Schleuse (1)
- Schmerzen (1)
- Schultergelenk (1)
- Schultergelenkluxation (1)
- Schultergelenkverletzung (1)
- Sehnenersatz (1)
- Sekundäre Inflammation (1)
- Selektiver Serotonin Wiederaufnahmehemmer / SSRI (1)
- Self-Evaluation Programs (I2.399.780) (1)
- Shigella flexneri (1)
- Shimmer (1)
- Signaltransduktion (1)
- Simulation (1)
- Sinorhizobium fredii (1)
- Sinusthrombose (1)
- Skin (1)
- Sleep (1)
- Sleeping Beauty Transposon System (1)
- Solid-phase peptide synthesis (1)
- Sonderforschungsbereich Transregio 240 (1)
- Spatiotemporal analysis (1)
- Speicheldrüse (1)
- Sphingolipid biology (1)
- Sphingolipide (1)
- Spred-Proteine (1)
- Staphylococcus aureus (1)
- Startle (1)
- Stent Retriever Schlaganfall (1)
- Stimmstabilität (1)
- Stoffwechsel (1)
- Stoffwechselinhibitoren (1)
- Support Vector Machine (1)
- Surveillance (1)
- T-Zelle (1)
- TAC (1)
- TKI (1)
- TLR3 (1)
- TNF Superfamilie (1)
- TNFR2 (1)
- Tagesrhythmus (1)
- Tanzania (1)
- Teaching (1)
- Thrombolysis stroke (1)
- Tissue Engineering (1)
- Toll-like receptor (1)
- Toll-like-Rezeptor (1)
- Trainingsfall (1)
- Trans-reservatrol (1)
- Transcription initiation (1)
- Transferases (1)
- Transkriptionsfaktor (1)
- Transkriptomanalyse (1)
- Transposon (1)
- Treadmill training (1)
- Trypanosoma brucei (1)
- Trypanosoma brucei brucei (1)
- Trypanosoma-brucei (1)
- Tumorhypoxie (1)
- Tumorzelle (1)
- Typhoid-fever (1)
- UHPLC (1)
- UHPLC-ESI-MS/MS (1)
- Uganda (1)
- Unconventional T cells (1)
- Urothelkarzinom (1)
- VSG (1)
- Verkalkung (1)
- Virtuelle Realität (1)
- Virusreplikation (1)
- Vitamin D (1)
- Vitamin D Mangel (1)
- Vitamin-D-Mangel (1)
- WHO-Klassifikation 2007 (1)
- Wachstumsfaktor (1)
- Warburg, Otto (1)
- Warburg-Effekt (1)
- Wilms tumor (1)
- Wundheilung (1)
- Xerostomie (1)
- Zelldifferenzierung (1)
- Zellkern (1)
- Zellkernarchitektur (1)
- Zellkultur (1)
- Zellzyklus (1)
- Zellüberleben (1)
- Zufriedenheitsanalyse (1)
- Zylindergriff (1)
- abscission (1)
- acquired immunodeficiency-syndrome (1)
- actin (1)
- active zone (1)
- adipocyte (1)
- adipose (1)
- adjuvant (1)
- adolescent (1)
- adrenocortical carcinoma (1)
- adult neurogenesis (1)
- affect-regulating massage therapy (1)
- affective touch (1)
- agomelatine (1)
- alfa-cyano-4-hydroxycinnamat (1)
- analysis of variance (1)
- angiography (1)
- anorexia nervosa (1)
- anticoagulants (1)
- antigenic variation (1)
- antimicrobial stewardship (1)
- anxiolytics (1)
- associative memory (1)
- atonia (1)
- atrial fibrillation (1)
- autonomic balance (1)
- autonomic nervous system (1)
- behavior (1)
- biomarker (1)
- bladder cancer (1)
- blood (1)
- blood brain barrier (1)
- body psychotherapy (1)
- body weight regulation (1)
- breast cancer (1)
- c-Myc (1)
- cAMP (1)
- cGMP (1)
- cGMP/cAMP-Crosstalk (1)
- cardiac hypertrophy (1)
- cardiac surgery (1)
- cardiopulmonary exercise testing (1)
- cardiotoxicity (1)
- cardiovascular magnetic resonance (1)
- cartilage (1)
- central lung (1)
- chemotherapy (1)
- childhood and adolescence (1)
- children (1)
- chromosome conformation capture (1)
- chronic thromboembolic pulmonary hypertension (1)
- cirrhosis (1)
- cleft lip and palate (1)
- clinical trials (1)
- congenital ocular motor apraxia (1)
- contact (1)
- contrast (1)
- coronary disease (1)
- cruzi (1)
- cylinder gripping (1)
- delayed bone healing (1)
- dialysepflichtige Niereninsuffizienz (1)
- differentiated thyroid carcinoma (1)
- dilated cardiomyopathy (1)
- distale Radiusfraktur (1)
- distale instabile Radiusfraktur (1)
- double-strand break repair (1)
- drug (1)
- drugs (1)
- dsRNA binding protein (1)
- dyspnea (1)
- eicosanoids (1)
- emission-computed-tomography (1)
- emotions (1)
- endomyocardial biopsy (1)
- endovascular recanalization stroke (1)
- endovaskuläre Therapie Hirninfarkt (1)
- esophagoscopy (1)
- etiology (1)
- evolution (1)
- execise capacity (1)
- fMRI (1)
- fMRI time series (1)
- face (1)
- facet joint degeneration (1)
- facet joint injection (1)
- feigned loss of strength (1)
- finger joint fusion (1)
- fluorescence (1)
- follow-up (1)
- foxes vulpes-vulpes (1)
- fruit-flies (1)
- fundamental frequency (1)
- funktionelle Kernspintomographie (1)
- gastrointestinal motility (1)
- gastrointestinale Motilität (1)
- gastronintestinal microbiota (1)
- gefitinib (1)
- gene expression heterogeneity (1)
- genes (1)
- genome packaging (1)
- genotype (1)
- geschlossene präoperative Reposition (1)
- gezielte Therapie (1)
- glucocorticoid receptor (1)
- glycolysis (1)
- gp130 (1)
- guanosine (1)
- guide effiiciency (1)
- haematobium (1)
- haemostasis (1)
- health (1)
- health care workers (1)
- heart (1)
- heart rate (1)
- helminths (1)
- hepatitis B (1)
- hepatitis B virus (1)
- hepatitis C virus (1)
- herpes simplex (1)
- hippocampus (1)
- histone H3 (1)
- histone variants (1)
- human adipose tissue (1)
- human african trypanosomiasis (1)
- human cell nucleus (1)
- human-immunodeficiency-virus (1)
- hypoxanthine (1)
- iberis amara extract (1)
- immune evasion (1)
- immunodiagnosis (1)
- in vitro (1)
- in vitro Kulturmodelle (1)
- in vitro Testsystem (1)
- incidence (1)
- inconsistencies (1)
- injury prevention (1)
- innate immunity (1)
- inosine (1)
- insertable cardiac monitor (1)
- insulin resistance (1)
- interactome (1)
- interoception (1)
- intervention (1)
- intestinal mucus (1)
- intravenöse Immunglobuline (1)
- invasive cysticerocsis (1)
- iodine-131 (1)
- ischemia (1)
- ischemic stroke (1)
- japonicum (1)
- kieferorthopädische Frühbehandlung (1)
- kolorektale Karzinomzelllinien (1)
- konditioneller Knockout (1)
- late-onset (1)
- ligation (1)
- lipid rafts (1)
- load distribution (1)
- long ncRNA (1)
- long-term complications (1)
- lumbar degenerative disease (1)
- lumbar spinal stenosis (1)
- lung cancer (1)
- lyso-Gb3 (1)
- machine learning (1)
- macrophage (1)
- managing big data (1)
- mass vaccination (1)
- massage therapy (1)
- match load (1)
- mechanical thrombectomy stroke (1)
- mechanische Thrombektomie (1)
- mechanism (1)
- medicine (1)
- megakaryocytes (1)
- melatonin (1)
- mental health (1)
- metabolism (1)
- metagenomics (1)
- metaproteomics (1)
- metatranscriptomics (1)
- miR-223-5p (1)
- miRNS (1)
- microalga-bacteria interaction (1)
- microbiology (1)
- microbiota (1)
- microprocessor (1)
- midbody (1)
- mitosis (1)
- molar tooth sign (1)
- molecular alterations (1)
- mossy fiber terminal (1)
- multiple myeloma (1)
- murine (1)
- mutation (1)
- mutation screening (1)
- mutually exclusive expression (1)
- myocardial infarction (1)
- myocarditis (1)
- natural genetic variation (1)
- nesbitti (1)
- non-contact´ (1)
- non-union (1)
- noninvasive detection (1)
- nuclear architecture (1)
- obere Extremität (1)
- obesity (1)
- off-targets (1)
- omega-3 fatty acids (1)
- onkologische Patienten (1)
- opponent processes (1)
- oro-faziale Spaltbildungen (1)
- outbreak (1)
- p53 (1)
- pain (1)
- pancreatic cancer (1)
- parasitology (1)
- parasomn (1)
- patient (1)
- perfusion (1)
- periodische Katatonie (1)
- phagocytosis (1)
- phosphorylation (1)
- phycosphere biofilm (1)
- pioglitazone (1)
- pkd (1)
- plant symbioses (1)
- plasmid copy number (1)
- point-of-care test (1)
- polymorphism (1)
- post-transcriptional regulation (1)
- postradiogene Xerostomie (1)
- pre-analytical variation (1)
- pre-orthodontic treatment (1)
- precision medicine (1)
- preoperative closed reduction (1)
- preoperative pain level (1)
- prevention (1)
- primary prophylaxis (1)
- prognostic awareness (1)
- prognostic value (1)
- protein (1)
- präoperatives Schmerzniveau (1)
- psychische Beschwerden (1)
- psychoactive massage (1)
- pulmonary artery (1)
- pulmonary artery pressure (1)
- pulmonary circulation (1)
- pulmonary embolism (1)
- pulmonary hypertension (1)
- pulmonary toxicity (1)
- punishment (1)
- quality indicators (1)
- quality of life (1)
- questionnaires (1)
- quorum sensing (QS) (1)
- rRNA depletion (1)
- radioiodine therapy (1)
- randomized-trial (1)
- rats (1)
- reactive oxygen species (1)
- reaktive Sauerstoffradikale (1)
- refeeding syndrome (1)
- relief (1)
- renal failure requiring hemodialysis (1)
- renale Kalzifikationen (1)
- repositories (1)
- reproducible science (1)
- respiratory pump (1)
- reverse genetics (1)
- reward (1)
- sRNA atlas (1)
- scintigraphy (1)
- second primary malignancy (1)
- serial RNA interactome capture (1)
- seroprevalence (1)
- service infrastructure (1)
- side effects (1)
- single-cell RNA-seq (1)
- sleep-related eating (1)
- sleeping sickness (1)
- social anxiety disorder (1)
- spatial organization (1)
- spectrin (1)
- standards (1)
- steerable sheath (1)
- stent retriever stroke (1)
- steuerbare Schleuse (1)
- streptozotocin (1)
- stress perfusion (1)
- stroke prevention (1)
- stroke treatment (1)
- subkutan / subcutaneous (1)
- submaximal effort (1)
- submaximal force measurement (1)
- submaximale Kraftanstrengung (1)
- submaximale Kraftmessung (1)
- surgical antimicrobial prophylaxis (1)
- surgical site infections (1)
- sustained fear (1)
- syphilis (1)
- targeted re-sequencing (1)
- targeted therapy (1)
- test system (1)
- therapy (1)
- time-to-centrifugation (1)
- tool (1)
- transcription factors (1)
- transcription start sites (1)
- transitional cell carcinoma (1)
- transport (1)
- travelers (1)
- treatment (1)
- unstable distal radius fracture (1)
- upper extremity (1)
- upstream regulator (1)
- urine samples (1)
- vaccine (1)
- variant of unknown significance (1)
- variant surface glycoprotein (1)
- vegetarians (1)
- verzögerte Heilung (1)
- viral assembly (1)
- virtual reality (1)
- vorgetäuschter Kraftverlust (1)
- weight loss (1)
- women (1)
- wound healing (1)
- wrist fusion (1)
- young females (1)
- Ätiologie (1)
- Überlebensrate dentaler Implantate (1)
Institute
- Medizinische Fakultät (161) (remove)
Sonstige beteiligte Institutionen
- Comprehensive Cancer Center Mainfranken (2)
- Helmholtz Institute for RNA-based Infection Research (HIRI) (2)
- Lehrkrankenhaus II. Medizinische Klinik Klinikum Coburg (2)
- Bayer AG, Research & Development, Pharmaceuticals, Investigational Toxicology (1)
- Boston Children's Hospital (1)
- Comprehensive Heart Failure Center Wuerzburg (CHFC) (1)
- Eberhard Karls Universität Tübingen (1)
- Institut für diagnostische und interventionelle Radiologie, Klinikum Ingolstadt (1)
- Interdisciplinary Bank of Biological Material and Data Würzburg (IBDW) (1)
- Juliusspital, Würzburg (1)
The clinical picture of depressive disorders is characterized by a plethora of somatic symptoms, psychomotor retardation, and, particularly, anhedonia. The number of patients with residual symptoms or treatment resistance is high. Touch is the basic communication among humans and animals. Its application professionally in the form of, e.g., psychoactive massage therapy, has been shown in the past to reduce the somatic and mental symptoms of depression and anxiety. Here, we investigated the effects of a specially developed affect-regulating massage therapy (ARMT) vs. individual treatment with a standardized relaxation procedure, progressive muscle relaxation (PMR), in 57 outpatients with depression. Patients were given one ARMT or PMR session weekly over 4 weeks. Changes in somatic and cognitive symptoms were assessed by standard psychiatric instruments (Hamilton Depression Scale (HAMD) and the Bech–Rafaelsen–Melancholia–Scale (BRMS)) as well as a visual analogue scale. Furthermore, oral statements from all participants were obtained in semi-structured interviews. The findings show clear and statistically significant superiority of ARMT over PMR. The results might be interpreted within various models. The concept of interoception, as well as the principles of body psychotherapy and phenomenological aspects, offers cues for understanding the mechanisms involved. Within a neurobiological context, the significance of C-tactile afferents activated by special touch techniques and humoral changes such as increased oxytocin levels open additional ways of interpreting our findings.
Published studies on the risk of radiation-induced second primary malignancy (SPM) after radioiodine treatment (RAI) of differentiated thyroid cancer (DTC) refer mainly to patients treated as middle-aged or older adults and are not easily generalizable to those treated at a younger age. Here we review available literature on the risk of breast cancer as an SPM after RAI of DTC with a focus on females undergoing such treatment in childhood, adolescence, or young adulthood. Additionally, we report the results of a preliminary international survey of patient registries from academic tertiary referral centers specializing in pediatric DTC. The survey sought to evaluate the availability of sufficient patient data for a potential international multicenter observational case–control study of females with DTC given RAI at an early age. Our literature review identified a bi-directional association of DTC and breast cancer. The general breast cancer risk in adult DTC survivors is low, ~2%, slightly higher in females than in males, but presumably lower, not higher, in those diagnosed as children or adolescents than in those diagnosed at older ages. RAI presumably does not substantially influence breast cancer risk after DTC. However, data from patients given RAI at young ages are sparse and insufficient to make definitive conclusions regarding age dependence of the risk of breast cancer as a SPM after RAI of DTC. The preliminary analysis of data from 10 thyroid cancer registries worldwide, including altogether 6,449 patients given RAI for DTC and 1,116 controls, i.e., patients not given RAI, did not show a significant increase of breast cancer incidence after RAI. However, the numbers of cases and controls were insufficient to draw statistically reliable conclusions, and the proportion of those receiving RAI at the earliest ages was too low.In conclusion, a potential international multicenter study of female patients undergoing RAI of DTC as children, adolescents, or young adults, with a sufficient sample size, is feasible. However, breast cancer screening of a larger cohort of DTC patients is not unproblematic for ethical reasons, due to the likely, at most slightly, increased risk of breast cancer post-RAI and the expected ~10% false-positivity rate which potentially produced substantial “misdiagnosis.”
Introduction: Speckle-tracking echocardiography has recently emerged as a quantitative ultrasound technique for accurately evaluating myocardial function by analyzing the motion of speckles identified. Speckle-tracking obtained under stress may offer an opportunity to improve the detection of dynamic regional abnormalities and myocardial viability.
Objective: To evaluate stress speckle tracking as tool to detect myocardial viability in comparison to cardiac MRI in post-STEMI patients.
Methods: 49 patients were prospectively enrolled in our 18-month’s study. Dobutamin stress echocardiography was performed 4 days post-infarction accompanied with automated functional imaging (Speckle tracking) analysis of left ventricle during rest and then during low dose stress. All patients underwent a follow up stress echocardiography at 6 weeks with speckle tracking analysis. Cardiac MRI took place concomitantly at 4 days post-infarction and 6 weeks. We carried out an assessment of re-admission with acute coronary syndrome (ACS) after one year of enrollment.
Results: Investigating strain rate obtained with stress speckle tracking after revascularization predicted the extent of myocardial scar, determined by contrast-enhanced magnetic resonance imaging. A good correlation was found between the global strain and total infarct size (R 0.75, p< 0.001). Furthermore, a clear inverse relationship was found between the segmental strain and the transmural extent of infarction in each segment. (R -0.69, p<0.01). Meanwhile it provided 81.82% sensitivity and 82.6% specificity to detect transmural from non-transmural infarction at a cut-off value of -10.15. Global stress strain rate showed 80% sensitivity and 77.5% specificity at a cut-off value of -9.1 to predict hospital re-admission with ACS. A cut-off value of -8.4 had shown a 69.23% sensitivity and 73.5% specificity to predict the re-admission related to other cardiac symptoms.
Conclusion: Strain rate obtained from speckle tracking during stress is a novel method of detecting myocardial viability after STEMI .Moreover it carries a promising role in post-myocardial infarction risk stratification with a reasonable prediction of reversible cardiac-related hospital re-admission.
The human body is colonized by trillions of microbes from all three domains of life – eukaryotes, bacteria and archaea. The lower gastrointestinal tract is the most densely colonized part of the body, harbouring a diverse and dynamic community of microbes. While the importance of bacteria in this so-called microbiota is well acknowledged, the role of commensal fungi remains underexplored. The most prominent fungus of the human gastrointestinal microbiota is Candida albicans. This fungus occasionally causes life-threatening disseminated infections in individuals with debilitated immune defences. It is this “pathogenic” facet that has received the most attention from researchers in the past, leaving many aspects of its “commensal” lifestyle understudied. Using gnotobiotic mice as a model system to explore the biology of C. albicans in the mammalian gut, in this dissertation I establish the global response of the host to C. albicans monocolonization as well as the spatial distribution of the fungus in the intestine in the context of co-colonization with single gut bacterial species. The fungus elicited transcriptome changes in murine intestinal tissue, which included the activation of a reactive oxygen species-related defence mechanism and the induction of regulators of the circadian clock circuitry. Both responses have previously been described in the context of a complete bacterial microbiota. Imaging the intestine of animals monocolonized with the fungus or co-colonized with C. albicans and the gut bacteria Bacteroides thetaiotaomicron or Lactobacillus reuteri revealed that the fungus was embedded in a B. thetaiotaomicron-promoted outer mucus layer in the murine colon. The gel-like outer mucus constitutes a unique microhabitat, distinct in microbial composition from the adjacent intestinal lumen. This finding indicates that bacteria can shape the specific microhabitat occupied by the fungus in the intestine. Overall, the results described in this dissertation suggest that gnotobiotic mice constitute a valuable tool to dissect multiple aspects of the interactions among host, commensal fungi and cohabiting bacteria.
In dieser Arbeit wurde die Herzratenvariabilität (HRV), das Interbeat-Intervall (IBI) sowie die Beziehung zwischen HRV und IBI bei gesunden Probanden, bradykarden Patienten mit einer Mutation im hyperpolarization-activated cyclic nucleotide-gated channel 4-(HCN4) Gen sowie Patienten mit einer Anorexie nervosa (AN) untersucht. Die Haupthypothese lautete, dass die bei Patienten mit AN oft zu beobachtenden Bradykardien durch neurale Mechanismen verursacht werden. Daher wurde angenommen, dass ein Sättigungseffekt der HRV/IBI Beziehung infolge einer anhaltenden parasympathischen Kontrolle des Sinusknotenareals lediglich bei Patienten mit einer AN nachzuweisen ist. In dieser Arbeit konnte ein Sättigungseffekt der HRV/IBI-Beziehung bei Patienten mit einer Anorexia nervosa sowie bei zwei von vier Patienten mit einer HCN4-Mutation nachgewiesen werden. Bei Kontrollen konnten hingegen kaum Zeichen eines Sättigungseffekts der HRV/IBI Beziehung nachgewiesen werden. Es wurde daher geschlussfolgert, dass ein Sättigungseffekt der HRV/IBI Beziehung keine parasympathisch-vermittelte Bradykardie beweist. Es zeigt sich vielmehr, dass die Regulation des HCN4-Gens für die Bradykardie und den festgestellten HRV-Sättigungseffekt bei Patienten mit einer AN verantwortlich sein könnte.
Reconstructing and understanding the Human Physiome virtually is a complex mathematical problem, and a highly demanding computational challenge. Mathematical models spanning from the molecular level through to whole populations of individuals must be integrated, then personalized. This requires interoperability with multiple disparate and geographically separated data sources, and myriad computational software tools. Extracting and producing knowledge from such sources, even when the databases and software are readily available, is a challenging task. Despite the difficulties, researchers must frequently perform these tasks so that available knowledge can be continually integrated into the common framework required to realize the Human Physiome. Software and infrastructures that support the communities that generate these, together with their underlying standards to format, describe and interlink the corresponding data and computer models, are pivotal to the Human Physiome being realized. They provide the foundations for integrating, exchanging and re-using data and models efficiently, and correctly, while also supporting the dissemination of growing knowledge in these forms. In this paper, we explore the standards, software tooling, repositories and infrastructures that support this work, and detail what makes them vital to realizing the Human Physiome.
Eine veränderte Expression des Transkriptionsfaktors MYC wird als entscheidender Faktor für Tumorentstehung und -progress im kolorektalen Karzinom gesehen. Somit ist die Hemmung dessen Expression und Funktion ein zentraler Ansatz bei der zielgerichteten Tumortherapie.
Als geeignete Strategie, sowohl die Halbwertszeit als auch die Translation von MYC zu verringern, erschien eine duale PI3K-/mTOR-Hemmung durch den small molecule-Inhibitor BEZ235. Gegenteilig ist jedoch unter Behandlung mit BEZ235 eine verstärkte MYC-Expression in verschiedenen Kolonkarzinom-Zelllinien zu beobachten. Neben verstärkter Transkription, konnte eine verstärkte IRES-abhängige Translation von MYC nach Hemmung der mTOR-/5´Cap-abhängigen Translation durch BEZ235, als Ursache der MYC-Induktion nachgewiesen werden.
Es konnte gezeigt werden, dass die Induktion von MYC nach PI3K-/mTOR-Hemmung durch eine kompensatorische Aktivierung des MAPK-Signalwegs in Folge einer FOXO-abhängigen Induktion von Rezeptortyrosinkinasen, stattfindet.
Eine mögliche Strategie, diese Feedback-Mechanismen zu umgehen, ist die direkte Hemmung der Translationsinitiation. Hierfür wurden Rocaglamid und dessen Derivat Silvestrol als small molecule-Inhibitoren der eIF4A-Helikase verwendet. Im Gegensatz zur PI3K/mTOR-Hemmung, ist durch eIF4A-Inhibition eine Reduktion der MYC-Proteinexpression in verschiedenen Kolonkarzinom-Zelllinien zu erreichen – ohne einhergehende MAPK-Aktivierung.
Anhand der Ergebnisse kann postuliert werden, dass Silvestrol das Potential besitzt, sowohl die Cap-/eIF4F-abhängie als auch die somit eIF4A-abhängige IRES-vermittelte Translation von MYC zu hemmen.
Weiterhin kann eine proliferationshemmende Wirkung durch Silvestrol auf Kolonkarzinom-Zellen in vitro, via Zellzyklusarrest und Induktion von Apoptose, gezeigt werden. Dies stellt die Voraussetzung für eine potentielle Eignung als tumorhemmender Wirkstoff in der Therapie des kolorektalen Karzinoms dar.
Antigenic variation of surface proteins is a commonly used strategy among pathogens to evade the host immune response [63]. The mechanism underlying antigenic variation relies on monoallelic exclusion of a single gene from a hypervariable multigene family combined with repeated, systematic changes in antigen expression. In many systems, these gene families are arranged in subtelomeric contingency loci that are subject to both transcriptional repression and enhanced mutagenesis and recombination [16].
Eviction of a selected gene from a repressed antigen repertoire can be achieved e.g. by recombination into a dedicated, transcriptionally permissive site or by local epigenetic alterations in chromatin composition of the selected gene.
Both processes are ultimately affected by genome architecture. Architectural proteins controlling antigenic variation have, however, remained elusive in any pathogen.
The unicellular protozoan parasite Trypanosoma brucei evades the host immune response by periodically changing expression of a single variant surface glycoprotein (VSG) from a repertoire of ~3000 VSG genes – the largest mutually exclusively expressed gene family described today. To activate a selected VSG gene, it needs to be located in a dedicated expression site that becomes subject to relocation into a distinct, transcriptionally active subnuclear compartment, the expression site body (ESB). Whereas this emphasizes the importance of nuclear architecture in regulating antigen expression in T. brucei, the mechanisms underlying spatial positioning of DNA in T. brucei are not well understood.
In this study I applied genome-wide chromosome conformation capture (Hi-C) to obtain a comprehensive picture of the T. brucei genome in three dimensions, both in procyclic and bloodstream form parasites. Hi-C revealed a highly structured nucleus with megabase chromosomes occupying distinct chromosome territories. Further, specific trans interactions between chromosomes, among which are clusters of centromeres, rRNA genes and procyclins became apparent. With respect to antigenic variation, Hi-C revealed a striking compaction of the subtelomeric VSG gene repertoire and a strong clustering of transcriptionally repressed VSG-containing expression sites. Further, Hi-C analyses confirmed the spatial separation of the actively transcribed from the silenced expression sites in three dimensions.
I further sought to characterize architectural proteins mediating nuclear architecture in T. brucei. Whereas CTCF is absent in non-metazoans, we found cohesin to be expressed throughout the cell cycle, emphasizing a function beyond sister chromatid cohesion in S-phase.
By Chromatin-Immunoprecipitation with sequencing (ChIPseq), I found cohesin enrichment to coincide with the presence of histone H3 vari- ant (H3.V) and H4 variant (H4.V). Most importantly, cohesin and the histone variants were enriched towards the VSG gene at silent and active expression sites.
While the deletion of H3.V led to increased clustering of expression sites in three dimensions and increased chromatin accessibility at expression site promoters, the additional deletion of H4.V increased chromatin accessibility at expression sits even further.
RNAseq showed that mutually exclusive VSG expression was lost in H3.V and H4.V single and double deletion mutants. Immunofluorescence imaging of surface VSGs, flow cytometry and single-cell RNAseq revealed a progressive loss of VSG-2 expression, indicative of an increase in VSG switching rate in the H3.V/H4.V double deletion mutants. Using long-read sequencing technology, we found that VSG switching occurred via recombination and concluded, that the concomitant increase in spatial proximity and accessibility among expression sites facilitated the recombination event.
I therefore identified the histone variants H3.V and H4.V to act at the interface of global nuclear architecture and chromatin accessibility and to represent a link between genome architecture and antigenic variation.
A mouse model for genetic deletion of presynaptic BDNF from adult hippocampal mossy fiber terminals
(2020)
Brain-derived neurotrophic factor (BDNF) is a modulator and mediator of structural and functional plasticity at synapses in the central nervous system. Despite our profound knowledge about the synaptic function of BDNF at synapses, it is still controversially discussed whether synaptic BDNF acts primarily from pre- or postsynaptic sites. In the central nervous system, several studies show that mossy fiber (MF) projections formed by hippocampal granule neurons store the highest amount of BDNF. However, immunofluorescence and RNA labelling studies suggest that MF BDNF is primarily produced by granule neurons. Multiple other studies prefer the view that BDNF is primarily produced by postsynaptic neurons such as CA3 pyramidal neurons. Here, we question whether the BDNF, which is stored in the mossy fiber synapse, is primarily produced by granule neurons or whether by other cells in the MF-CA3 microcircuit. After standardization of immunolabelling of BDNF, confocal imaging confirmed the localization of BDNF in presynaptic MF terminals. This anterograde location of synaptic BDNF was also found in distinct regions of the fear and anxiety circuit, namely in the oval nucleus of the bed nucleus stria terminals (ovBNST) and in the central amygdala. To find out whether the presynaptic BDNF location is due to protein translation in the corresponding presynaptic dentate gyrus (DG) granule neuron, we developed and characterized a mouse model that exhibits BDNF deletion specifically from adult DG granule neurons. In this mouse model, loss of presynaptic BDNF immunoreactivity correlated with the specific Creactivity in granule neurons, thus confirming that MF BDNF is principally released by granule neurons. After BDNF deletion from granule neurons, we observed more immature neurons with widely arborized dendritic trees. This indicated that local BDNF deletion also affects the local adult neurogenesis, albeit Cre-mediated BDNF deletion only occur in adult granule neurons. Since BDNF is a master regulator of structural synaptic plasticity, it was questioned whether it is possible to visualize presynaptic, synapse-specific, structural plasticity in mossy fiber synapses. It was established that a combination of Cre-techniques together with targeting of GFP to membranes with the help of palmitoylation / myristoylation anchors was able to distinctly outline the synaptic structure of the BDNF-containing MF synapse. In summary, the mouse model characterized in here is suited to investigate the synaptic signalling function of presynaptic BDNF at the mossy fiber terminal, a model synapse to investigate microcircuit information processing from molecule to behaviour.
Trotz der Fortschritte in der Therapie des Multiplen Myeloms und des stetig wachsenden Arsenals effektiver anti-MM-Medikamente muss ein Teil der Patienten mit bestimmten zytogenetischen Veränderungen der Tumorzellen nach wie vor der Hochrisiko-Gruppe zugeordnet werden und hat eine Lebens-erwartung von nur wenigen Jahren. Einer der ungünstigsten prognostischen Marker ist die Inaktivierung des Tumorsuppressorgens TP53 durch Mutationen des Gens oder Deletionen des kurzen Arms von Chromosom 17, del(17p). Diese wird häufig mit einer Chemoresistenz der entarteten Plasmazellen in Verbindung gebracht.
In der vorliegenden Arbeit gelang es mittels des CRISPR/Cas9-Systems TP53-Läsionen zu erzeugen und isogene Klone der TP53wt/wt Zelllinie AMO-1 zu generieren. Diese wurden anhand der Sequenzanalysen von beiden TP53-Allelen den Gruppen der biallelisch TP53-inaktivierten, der monoallelisch TP53-inaktivierten und der TP53wt/wt Klone zugeordnet. Das gruppenspezifische Verhalten der Klone aller drei Gruppen hinsichtlich deren Expression von p53, p21 und Mdm2 unterstrich die Validität des etablierten Zelllinienmodells zur Untersuchung der Bedeutung von TP53-Läsionen beim Multiplen Myelom. Neben einer kompletten Ausschaltung durch biallelische TP53-Inaktivierung zeigten die Ergebnisse der vorliegenden Arbeit auch eine Haploinsuffizienz des p53-Systems. Diese äußerte sich in einer Abschwächung der Nutlin-3A-abhängigen p53-, p21- und Mdm2-Induktion bereits nach Inaktivierung eines TP53-Allels durch Frameshift-Mutation. Korrelierend zu dem Proteinexpressions¬muster konnte eine zunehmende Resistenzentwicklung der Klone je nach Grad der TP53-Inaktivierung (mono- bzw. biallelisch) gegen Nutlin 3A sowie genotoxische Substanzen nachgewiesen werden, während die Sensibilität der MM-Zellen gegen Proteasominhibitoren unbeeinträchtigt blieb. Einschränkungen hinsichtlich der Übertragbarkeit der Ergebnisse der vorliegenden Arbeit auf das Multiple Myelom im Allgemeinen bestehen in dem Umstand, dass die beschriebenen Beobachtungen lediglich an einer einzigen MM-Zelllinie gemacht werden konnten. Dies ist durch die geringe Auswahl an TP53wt/wt MM-Zelllinien, die zudem noch oft eine schlechte Transfektabilität und niedrige Zellteilungsrate nach Einzelzellselektion aufweisen, bedingt.
Die an der Zelllinie AMO-1 gemachten Beobachtungen stehen in Einklang mit der in klinischen Studien festgestellten Verkürzung des progressionsfreien- (PFS) und Gesamt-Überlebens (OS) bei MM-Patienten mit TP53-Alterationen. Die zunehmende Chemoresistenz der malignen Plasmazellen nach mono- bzw. biallelischer TP53-Inaktivierung kann als Grund für die Akkumulation entsprechender Klone im Rezidiv und in fortgeschrittenen Krankheitsstadien des MM angesehen werden. Mittels möglichst umfassender Erfassung des genauen TP53-Läsions-Status in zukünftigen klinischen Studien zu multiplen Zeitpunkten des Krankheitsverlaufs könnte der Einfluss verschiedener, in der Therapie des MM zum Einsatz kommender Substanzen auf die Selektion bzw. die Unterdrückung besonders virulenter Subklone mit TP53-Läsionen untersucht werden.