Refine
Has Fulltext
- yes (574)
Is part of the Bibliography
- yes (574)
Year of publication
- 2018 (574) (remove)
Document Type
- Journal article (385)
- Doctoral Thesis (156)
- Preprint (22)
- Conference Proceeding (3)
- Other (2)
- Working Paper (2)
- Book (1)
- Book article / Book chapter (1)
- Habilitation (1)
- Master Thesis (1)
Language
- English (574) (remove)
Keywords
- Parton Distributions (23)
- Hadron-Hadron scattering (experiments) (16)
- Positronen-Emissions-Tomografie (16)
- Extension (14)
- PET (14)
- Decay (13)
- boron (12)
- Squark (11)
- ++ (10)
- positron emission tomography (9)
- Mass (7)
- Maus (7)
- Physics (7)
- Cross-Section (6)
- Gluino Production (6)
- LHC (6)
- Parton distributions (6)
- diborenes (6)
- Higgs bosons (5)
- MASS (5)
- Model (5)
- SPECT (5)
- carbenes (5)
- inflammation (5)
- neuroendocrine tumor (5)
- ADHD (4)
- Beyond Standard Model (4)
- Breaking (4)
- Distributions (4)
- Energy (4)
- Fluoreszenzmikroskopie (4)
- Hadron colliders (4)
- Hierarchy (4)
- Models (4)
- PRRT (4)
- Stress (4)
- Supersymmetry (4)
- Thrombozyt (4)
- Top quark (4)
- Topologischer Isolator (4)
- ageing (4)
- cancer (4)
- physical activity (4)
- 18F-DCFPyL (3)
- 18F-FDG (3)
- Aspergillus fumigatus (3)
- Biene (3)
- Biofilm (3)
- Boson (3)
- DaTscan (3)
- Events (3)
- Fluorescence (3)
- Fluoreszenz (3)
- G-Protein gekoppelte Rezeptoren (3)
- Hadron Colliders (3)
- Kernspintomografie (3)
- MRI (3)
- Makroökonomie (3)
- Measuring Masses (3)
- Microscopy (3)
- Monte-Carlo (3)
- PET/CT (3)
- Particle data analysis (3)
- Polymere (3)
- RADS (3)
- SSTR (3)
- Search (3)
- Stammzelle (3)
- Staphylococcus aureus (3)
- Supersymmetric models (3)
- T cells (3)
- Thrombose (3)
- Trypanosomen (3)
- Weak (3)
- apoptosis (3)
- breast cancer (3)
- children (3)
- diborynes (3)
- epigenetics (3)
- glycine receptor (3)
- immune evasion (3)
- induced pluripotent stem cells (3)
- infection (3)
- machine learning (3)
- mitochondria (3)
- mouse model (3)
- obesity (3)
- pathogens (3)
- prostate cancer (3)
- psychology (3)
- self-assembly (3)
- spectroscopy (3)
- stroke (3)
- super-resolution microscopy (3)
- theranostics (3)
- 11C-HED (2)
- 123I-mIBG (2)
- 123I-metaiodobenzylguanidine (2)
- 18F-LMI1195 (2)
- ABCG2 (2)
- Activation (2)
- Alzheimer’s disease (2)
- Ants (2)
- Apis mellifera (2)
- Arteriosklerose (2)
- Arzneimittelforschung (2)
- B cells (2)
- BRAF (2)
- Biomarkers (2)
- Boron (2)
- Bosons (2)
- Cadherine (2)
- Camponotus floridanus (2)
- Cancer immunotherapy (2)
- Candida albicans (2)
- Catalysis (2)
- China (2)
- Code examples (2)
- Coffin-Lowry syndrome (2)
- DFT calculations (2)
- DNA (2)
- Diabetes mellitus (2)
- Drosophila (2)
- Drosophila melanogaster (2)
- E. coli Nissle 1917 (2)
- EHEC (2)
- Ecology (2)
- Emotion (2)
- Entwicklung (2)
- Epigenetik (2)
- Europäische Union (2)
- Extrazelluläre Matrix (2)
- Femtosekundenspektroskopie (2)
- Fernerkundung (2)
- GPCR (2)
- Genom (2)
- Gluino production (2)
- Hämostase (2)
- Innate immunity (2)
- Ioflupane (2)
- Jets (2)
- Leistungsbewertung (2)
- Mikroskopie (2)
- Muscarinrezeptor (2)
- Myc (2)
- NFATc1 (2)
- Neisseria meningitidis (2)
- Netzwerk (2)
- Optische Spektroskopie (2)
- PSMA-PET (2)
- Pair production (2)
- Parkinson (2)
- Parkinson Disease (2)
- Parkinson-Krankheit (2)
- Patron Distributions (2)
- Performance Evaluation (2)
- Phänologie (2)
- Plasma (2)
- Plus plus (2)
- Positron Emission Tomography (2)
- Program (2)
- Prostate Cancer (2)
- Proton-Proton Collisions (2)
- QAHE (2)
- QCD (2)
- Quanten-Hall-Effekt (2)
- Quecksilbertellurid (2)
- RSK2 (2)
- Rhodium (2)
- Risk factors (2)
- SPECT/CT (2)
- SQH method (2)
- Signaltransduktion (2)
- Simulation (2)
- Sozialpsychologie (2)
- Squaraine (2)
- Staphylococci (2)
- Streptomyces (2)
- Supramolekulare Chemie (2)
- Survival (2)
- Symmetry (2)
- Symmetry-breaking (2)
- Tagesrhythmus (2)
- Taufliege (2)
- Textverstehen (2)
- Timing (2)
- Transcriptome (2)
- Trypanosoma brucei (2)
- Ultrakurzzeitspektroskopie (2)
- Umverteilung (2)
- Ungleichheit (2)
- Virchow Node (2)
- Virulenzfaktor (2)
- WZ (2)
- X-ray crystallography (2)
- [177Lu]-DOTATATE/-DOTATOC (2)
- [68Ga] (2)
- adolescents (2)
- anxiety (2)
- basal ganglia (2)
- bees (2)
- bioinformatics (2)
- biological models (2)
- biomarker (2)
- biomedical materials (2)
- bipolar disorder (2)
- borylene (2)
- calcium (2)
- carbon dioxide (2)
- cardiomyocytes (2)
- chemokines (2)
- chronic kidney disease (2)
- circadian clock (2)
- circadian rhythm (2)
- classification (2)
- data mining (2)
- depression (2)
- desirable difficulties (2)
- diet (2)
- diradicals (2)
- division of labor (2)
- electronic properties and materials (2)
- emotion (2)
- evolution (2)
- fatty acid (2)
- ferroelectricity (2)
- fitness (2)
- fluorescence (2)
- foraging (2)
- forest health (2)
- gamma rays (2)
- genomics (2)
- glucose (2)
- haematopoietic stem cells (2)
- heart failure (2)
- hemodialysis (2)
- hiPSC-CM (2)
- honeybee (2)
- human (2)
- immunology (2)
- insulin (2)
- interferon (2)
- knee arthroplasty (2)
- lambdoid prophage (2)
- land use (2)
- load management (2)
- low-valent compounds (2)
- medullary thyroid carcinoma (2)
- melanoma (2)
- metabolism (2)
- metabolomics (2)
- miRNS (2)
- molecular imaging (2)
- mothers (2)
- muscle degeneration (2)
- myocardial sympathetic innervation imaging (2)
- neuroblastoma (2)
- optical spectroscopy (2)
- optimization (2)
- optogenetics (2)
- pancreas (2)
- periprosthetic infection (2)
- personalized medicine (2)
- personalized treatment (2)
- platelets (2)
- polymer (2)
- pp Collisions (2)
- pp collisions (2)
- precision medicine (2)
- proteins (2)
- self (2)
- sensor fusion (2)
- somatostatin receptor (2)
- spontaneous symmetry breaking (2)
- startle disease (2)
- stem cell therapy (2)
- stx-phages (2)
- symbiosis (2)
- therapy (2)
- tissue engineering (2)
- tracer (2)
- transcriptome (2)
- translational research (2)
- tumor heterogeneity (2)
- two-stage exchange (2)
- tyrosine kinase inhibitor (2)
- vandetanib (2)
- virtual reality (2)
- *-algebra (1)
- 11C-Hydroxyephedrine (1)
- 11C-hydroxyephedrine (1)
- 123I-Ioflupane (1)
- 16S metabarcoding (1)
- 18F-FDS (1)
- 18F-flurpiridaz (1)
- 18FFBnTP (1)
- 2- deoxy-2-(18F)fluoro-D-glucose (1)
- 2-Aminoethylphosphonic acid (1)
- 2-deoxy-2-(18F)fluoro-D-glucose (1)
- 3D echocardiography (1)
- 3D modeling (1)
- 3D point cloud (1)
- 3D powder printing (1)
- 3D printing (1)
- 3D thermal mapping (1)
- 4TH-Corner Problem (1)
- 53BP1 (1)
- 68Ga-DOTATATE/-TOC (1)
- 8 TEV (1)
- 99mTc-DTPA (1)
- ACL (1)
- AChE inhibitor (1)
- ADHS (1)
- AI (1)
- AIME (1)
- AKI (1)
- AMP-activated protein kinase (AMPK) (1)
- AP1 (1)
- APC (1)
- ARPES (1)
- ATLAS <Teilchendetektor> (1)
- ATLAS New Small Wheels (NSW) (1)
- ATLAS experiment (1)
- Accelerator modelling and simulations (multi-particle dynamics; single-particle dynamics) (1)
- Achillea Fragrantissima (1)
- Acid adaptation (1)
- Ackerschmalwand (1)
- Acoustic equations (1)
- Acoustics (1)
- Acute myeloid leukemia (1)
- Acyrthosiphon pisum (1)
- AdS-CFT Correspondence (1)
- Adhäsion (1)
- Adipositas (1)
- Adsorption (1)
- Affekt (1)
- African trypanosomes (1)
- Agonist (1)
- Ahmed (1)
- Alemtuzumab (1)
- Algorithm (1)
- Algorithmus (1)
- Aliphatics (1)
- Alkaloide (1)
- Alkamiden (1)
- Alkamides (1)
- Allogeneic stem cell transplantation (1)
- Allotransplantation (1)
- Ameise (1)
- Ameisen (1)
- American foulbrood (1)
- Analysis (1)
- Anderson-Lokalisation (1)
- Aneuploidy (1)
- Angeborene Immunität (1)
- Angst (1)
- Animal behavior IntelliCage system (1)
- Animal model (1)
- Ant (1)
- Antibiotic (1)
- Antibody clearance (1)
- Antidepressants (1)
- Antitrypanosomal (1)
- Antitrypanosomen (1)
- Anxiety (1)
- Aorta (1)
- Approximationsalgorithmus (1)
- Arbeitsgedächtnis (1)
- Arbeitsmarkt (1)
- ArsZ (1)
- Arterie (1)
- Artery (1)
- Articular-Cartilage (1)
- Arzneimittel (1)
- Arzneimitteldesign (1)
- Aspergillus (1)
- AstA (1)
- Asylpolitik (1)
- Asymptotic Preserving (1)
- Atherosclerosis (1)
- Atmosphäre (1)
- Atomic and molecular interactions with photons (1)
- Atomketten (1)
- Atta vollenweideri (1)
- Attitudes towards immigrants (1)
- Auditory pathway (1)
- Aurora-A (1)
- Auto-Scaling (1)
- Automation (1)
- Automatisiertes Fahren (1)
- Autonomes Fahrzeug (1)
- Axion (1)
- B-0 (1)
- B-Lymphozyt (1)
- BB bond activation (1)
- BB/BC Bond activation (1)
- BC bond activation (1)
- BCL6 (1)
- BRCA1 (1)
- BRCA2 (1)
- BRIP1 gene (1)
- Bacillus subtilis (1)
- Bacteria (1)
- Bacterial infection (1)
- Baerveldt (1)
- Bakterien (1)
- Bakteriophagen (1)
- Banach-Raum (1)
- Bank Credit Market (1)
- Bankgeschäft (1)
- Bariumtitanat (1)
- Bayes analysis (1)
- Bayes-Verfahren (1)
- Bayesian methods (1)
- Bayesian model comparison (1)
- Beatty sequence (1)
- Beauveria bassiana (1)
- Beige adipocytes (1)
- Benchmarking (1)
- Benutzerinteraktion (1)
- Bewusstsein (1)
- Bi2Se3 (1)
- Bildgebendes Verfahren (1)
- Bildverarbeitung (1)
- Bioabbaubarkeit (1)
- Biochemical-Diagnosis (1)
- Biodegradability (1)
- Biodiversity (1)
- Biodiversity Exploratories (1)
- Biodiversitätsexploratorien (1)
- Biofilm formation (1)
- Biofilms (1)
- Bioinformatics (1)
- Bioinformatik (1)
- Biokinetics (1)
- Biologie (1)
- Biologischer Abbau (1)
- Biomarker (1)
- Biomechanical Properties (1)
- Biomedical engineering (1)
- Bioverfügbarkeit (1)
- Bipolar Disorder (1)
- Bismutselenide (1)
- Bodipy (1)
- Body size (1)
- Body weight (1)
- Bone (1)
- Bootstrap (1)
- Bor (1)
- Borylierung (1)
- Bottom-up (1)
- Breeding system (1)
- Bregman distance (1)
- Brushite (1)
- Bruton Tyrosine Kinase (1)
- Burgers-Gleichung (1)
- Burkina Faso (1)
- Butyrylcholinesterase (1)
- Bärtierchen (1)
- C-C coupling (1)
- C/EBP (1)
- C5aR1 (1)
- CAGSSS (1)
- CCHamide1 (1)
- CCL4 (1)
- CD28 costimulation (1)
- CD28 superagonists (1)
- CD3/19 depletion (1)
- CD34 selection (1)
- CD4\(^{+}\) T helper cells (1)
- CD52 (1)
- CD74 (1)
- CD8+ T cells (1)
- CDH13 (1)
- CDR3 sequences (1)
- CIR aerial imagery (1)
- CLEC-2 (1)
- CML (1)
- CNG channel (1)
- CNS (1)
- CO2 fixation (1)
- COMT (1)
- COPD (1)
- CPAF activation (1)
- CRAC (1)
- CRHR1 (1)
- CRISPR/Cas9 (1)
- CXCL13 (1)
- Ca2+ (1)
- Cadherin 13 (1)
- Cadherin-13 (1)
- Caenorhabditis elegans (1)
- Calcium (1)
- Calcium Citrate (1)
- Calcium phosphate (1)
- Calciumphosphate (1)
- Calibration (1)
- Camponotus (1)
- Cancer (1)
- Cancer models (1)
- Cancer therapeutic resistance (1)
- Cannabinoid Receptor (1)
- CarO (1)
- Carbenes (1)
- Cardiovascular biology (1)
- Cardiovascular diseases (1)
- Cartilage Regeneration (1)
- Catheter Lock Solution (1)
- Catheter-related Bloodstream Infections (CRBSI) (1)
- Cauchy-Born rule (1)
- Caudate nucleus (1)
- Cell differentiation (1)
- Cellular imaging (1)
- Central Spin (1)
- Ceramides (1)
- Cerebellar nuclei (1)
- ChIPseq (1)
- Chain-length distribution (1)
- Chains (1)
- Charged-Particles (1)
- Charm quark (1)
- Charmonia (1)
- Chemische Reaktion (1)
- Chemische Synthese (1)
- Chemistry (1)
- Chemotherapeutic resistance (1)
- Cherenkov detectors (1)
- Chimeric antigen receptor (1)
- Chinolonderivate (1)
- Chlamydia (1)
- Chlamydienkrankheit (1)
- Cholinesterase (1)
- Chromatin (1)
- Chromatin and Epigenetics (1)
- Chromophor (1)
- Chronic heart-failure (1)
- Chronic myeloid leukaemia (1)
- Chronobiologie (1)
- Circadian Clock (1)
- Circadiane Uhr (1)
- Circadianer Rhythmus (1)
- Circular dichroism (1)
- Climate change (1)
- Clinical trial (1)
- Clonality (1)
- Cloud Computing (1)
- Coffin–Lowry syndrome (1)
- Coherent Multidimensional Spectroscopy (1)
- Coherent control (1)
- Cohesin complex (1)
- Collagen (1)
- Collicions (1)
- Colloidal Stability (1)
- Color (1)
- Combination (1)
- Community ecology (1)
- Comparative genomics (1)
- Complexity (1)
- Component selectivity (1)
- Compressive Properties (1)
- Computational drug design (1)
- Computersimulation (1)
- Concealed Information Test (1)
- Confidence interval (1)
- Conformal Field Theory (1)
- Conical Intersection (1)
- Consistent partial least squares (1)
- Copal\(^®\) spacem (1)
- Copeptin (1)
- Copper (1)
- Copper catalysis (1)
- Copy number changes (1)
- Corneal confocal microscopy (1)
- Corticoliberin (1)
- Corynebacterium urealyticum (1)
- Counterfeit Medicines (1)
- Coupled Electron-Nuclear Dynamics (1)
- Cross-section (1)
- Cuticle (1)
- Cuticular water permeabilities (1)
- Cuticular waxes (1)
- Cyclics (1)
- Cyclotrimerisation (1)
- Cyropaidia (1)
- D665 (1)
- DCGAN (1)
- DECAY (1)
- DFNB68 (1)
- DFT-LDA (1)
- DHAP (1)
- DLBCL (1)
- DM2 (1)
- DNA Breaks (1)
- DNA catalyst (1)
- DNA complex (1)
- DNA damage (1)
- DNA methylation (1)
- DNA transcription (1)
- DNMR-Spektroskopie (1)
- DRG (1)
- DT40 cells (1)
- Dark-Matter (1)
- Dark-matter production (1)
- Data Science (1)
- DecaWave (1)
- Decay sequence (1)
- Decays (1)
- Decoherence (1)
- Deep Georeferencing (1)
- Deformation (1)
- Deformationsquantisierung (1)
- Delta Repertoire (1)
- Democracy Matrix (1)
- Dendritic cells (1)
- Dendritische Zelle (1)
- Dependence (1)
- Depression (1)
- Design (1)
- Desynchronisation (1)
- Desynchronization (1)
- Diabetic nephropathies (1)
- Diagnose (1)
- Diagnosis (1)
- Dicarboximide (1)
- Dicarboximides (1)
- Dietary process-related contaminants (1)
- Differential Cross-Sections (1)
- Differentialgleichung (1)
- Dilatometrie (1)
- Diophantine approximation (1)
- Dipeptidyl-peptidase IV inhibitors (1)
- Discrete-to-continuum limits (1)
- Disney (1)
- Disorder (1)
- Dmrt1bY (1)
- Doppelquantenkohärenz (1)
- Drahtloses Sensornetz (1)
- Drosophila Myc transcription growth PAF1 (1)
- Drosophila melanogaster motoneuron (1)
- Drosophila model (1)
- Drug delivery (1)
- Dualstere Liganden (1)
- Dualsteric Ligands (1)
- Dyad (1)
- Dyade (1)
- Dynamic magnetic resonance imaging (1)
- Dynamical Supersymmetry Breaking (1)
- Dynamics (1)
- Dynamische MR Bildgebung (1)
- Dynamische Messung (1)
- EAE (1)
- ECG (1)
- EDC-NHS chemistry (1)
- EEG (1)
- EU Governance (1)
- EW (1)
- Eccentricities (1)
- Ecological Networks (1)
- Ecological networks (1)
- Economic Growth (1)
- Ecosystem ecology (1)
- Effizienter Algorithmus (1)
- Efflux pump (1)
- Egypt (1)
- Einkommensverteilung (1)
- Einstellung gegenüber Immigranten (1)
- Einwanderung (1)
- Elasticity (1)
- Elasticity tensor (1)
- Elastizitätstensor (1)
- Elderly (1)
- Electron Flux (1)
- Electroweak interaction (1)
- Elektroencephalogramm (1)
- Elektronenspektroskopie (1)
- Elektronentransfer (1)
- Elite Rowers (1)
- Elliptische Differentialgleichung (1)
- Empirical Economics (1)
- Empirische Wirtschaftsforschung (1)
- Employment (1)
- Endogenous clock (1)
- Endophytische Pilze (1)
- Energieaufnahme (1)
- Energies (1)
- Energy Transfer (1)
- Enoyl-acyl-carrier-protein-Reductase <Enoyl-[acyl-carrier-protein]-Reductase> (1)
- Enterohemorrhagic Escherichia coli (1)
- Entomology (1)
- Entropiebedingung (1)
- Entropielösung (1)
- Entropy admissibility condition (1)
- Entwicklung chimärer Antigenrezeptor T-Zellen (1)
- Entzündung (1)
- Entzündungsschmerz (1)
- Enzymes (1)
- Enzyminhibitor (1)
- Epichloe (1)
- Epichloë (1)
- Epistemic Competences (1)
- Epistemische Kompetenzen (1)
- Epitope (1)
- Erythrozyt (1)
- Erythrozytenadhärenz (1)
- Euclidean plane (1)
- Euklidische Ebene (1)
- Euler equations (1)
- European Asylum System (1)
- European Union (1)
- European foulbrood (1)
- Europäische Zentralbank (1)
- Event (1)
- Exacerbation (1)
- Exazerbation (1)
- Excited states (1)
- Exciton dynamics (1)
- Excitons (1)
- Executive Compensation (1)
- Existenz und Eindeutigkeit (1)
- Exotic mesons (1)
- Experiment / Sozialpsychologie (1)
- Expression (1)
- Extensions of Higgs sector (1)
- Extensions of gauge sector (1)
- External exposure assessment (1)
- Extracellular matrix proteins (1)
- Exziton (1)
- F-actin (1)
- FAIR (1)
- FGF (1)
- FGF-2 (1)
- FGF21 (1)
- FV45 (1)
- Fabry disease (1)
- Fabry-Krankheit (1)
- Factor messenger-RNA (1)
- Fagus sylvatica (1)
- Fahrerablenkung (1)
- Fahrerverhalten (1)
- Fanconi anaemia (1)
- Farbensehen (1)
- Feedforward loop (1)
- Feldeffekttransistor (1)
- Femtosekundenlaser (1)
- Ferroelektrikum (1)
- Fibroblast Growth Factor-21 (1)
- Fibroblastenwachstumsfaktor (1)
- Field effect transistor (1)
- Finanzkrise (1)
- Finite-Volumen-Methode (1)
- Fitness (1)
- Flavoniden (1)
- Flavonoinds (1)
- Fluconazole (1)
- Fluid-Partikel-Strömung (1)
- Fluorescence Microscopy (1)
- Fluorescence Resonance Energy Transfer (1)
- Fluorescence resonance energy transfer (1)
- Fluorescence spectroscopy (1)
- Flüchtlingskrise (1)
- Flüssigkristall (1)
- Foraging behaviour (1)
- Formulierungsentwicklung (1)
- Fortran code (1)
- Fourier-Spektroskopie (1)
- Fragmentation (1)
- Fremdscham (1)
- Fremdschämen (1)
- Frequency (1)
- Fruit (1)
- Fulleren-Netzwerk (1)
- Fullerene (1)
- Functional differential equations (1)
- Fungal cell-walls (1)
- Fusarium fujikuroi (1)
- Fälschung (1)
- Förderung (1)
- G Protein-Coupled Receptors (1)
- G protein-coupled receptors (1)
- G-Protein gekoppelte Rezeptor (1)
- GABAerge Nervenzelle (1)
- GAMMA (1)
- GAN (1)
- GI (1)
- GLP-1 (1)
- GPVI (1)
- GPX4 (1)
- Galactosidase <alpha-> (1)
- Galectin-1 (1)
- Gamma (1)
- Gamma-convergence (1)
- Gasgemisch (1)
- Gasionisationsdetektor (1)
- Gastrointestinal (1)
- Gauge-gravity correspondence (1)
- Gb3 accumulation (1)
- Gefühl (1)
- Gehirn (1)
- Gehirn-Computer-Schnittstelle (1)
- Geitonogamy (1)
- Geldpolitik (1)
- Gene Regulation (1)
- Gene-expression (1)
- Gene-prediction (1)
- Generalized Nash Equilibrium Problem (1)
- Genetics (1)
- Genexpression (1)
- Genome editing (1)
- Genomeditierung (1)
- Genregulation (1)
- Geo-spatial behavior (1)
- Geografie (1)
- Geometric Phase (1)
- Georeferenzierung (1)
- German healthcare system (1)
- Germanium telluride (1)
- Germination (1)
- Geruchssinn (1)
- Gland (1)
- Global Change (1)
- Globaler Wandel (1)
- Globalisierung (1)
- Glomerular filtration (1)
- Gluon (1)
- Gluon Fusion (1)
- Glutamin (1)
- Glycoprotein GPV (1)
- Glykoproteine (1)
- God in 3 Macc (1)
- Gold-Nanoparticles (1)
- Golgi-Apparat (1)
- Governance (1)
- Graph (1)
- Gräser (1)
- Guinier-Preston zones (1)
- HECT (1)
- HFmrEF (1)
- HIGGS (1)
- HIV (1)
- HLA class II (1)
- HLA peptidome (1)
- HP1432, Hpn2 (1)
- HPLC (1)
- HUWE1 (1)
- Hadron Collider (1)
- Halbleiter (1)
- Haploidentical (1)
- Hardware (1)
- Heavy-Particles (1)
- Hekate (1)
- Helicität <Chemie> (1)
- Helicobacter pylori (1)
- Helix- and Zick-Zack-Konformere (1)
- Helix- and Zig-Zag-Conformers (1)
- Hellenistic kingship (1)
- Hematopoietic Stem Cell (1)
- Hemostasis (1)
- Herzinfarkt (1)
- Herzkatheter (1)
- Herzkathetereingriff (1)
- Heubacillus (1)
- Hexaarylbenzene (1)
- HgTe (1)
- Hibernation (1)
- Hic-5 (1)
- Hierarchische Matrix (1)
- Hierarchy problem (1)
- Higgs (1)
- Higgs boson (1)
- Higgs boson decays (1)
- Higgs boson mass (1)
- Higgs physics (1)
- High-throughput screening (1)
- Higher Education (1)
- Hippocampus (1)
- Histatin 5 (1)
- Historical Maps (1)
- Historische Karte (1)
- Historische Landkarten (1)
- Hochauflösende Mikroskopie (1)
- Homöostase (1)
- Hospitalismus <Hygiene> (1)
- Host defense (1)
- Host-endosymbiont interactions (1)
- Host-pathogen interaction (1)
- Host-pathogen interactions (1)
- Housing Markets (1)
- Hsp90 (1)
- Human Knee (1)
- Human Medial Meniscus (1)
- Human Resource Management <Humanvermögen> <Personalentwicklung> (1)
- Human behavior (1)
- Human behaviour (1)
- Hurst Exponent (1)
- Hyaluronic acid (1)
- Hyaluronsäure (1)
- Hybrid (1)
- Hybrid GPCR Ligands (1)
- Hydrogel (1)
- Hymenoptera (1)
- Hyperbolic Partial Differential Equations (1)
- Hyperbolische Differentialgleichung (1)
- Hypothesis comparison (1)
- Hypothetical gauge bosons (1)
- Hypothetical particle physics models (1)
- IARS2 (1)
- ICD (1)
- IDO-1 (1)
- IFN-gamma (1)
- IGF-I (1)
- IL-23 (1)
- Ibrutinib (1)
- Identification (1)
- Image Processing (1)
- Imatinib (1)
- Immun-Transkriptom (1)
- Immune Thrombocytopenia (1)
- Immunosuppression (1)
- Immunreaktion (1)
- Immunsystem (1)
- Immuntherapie (1)
- Immunthrombozytopenie (1)
- Importwettbewerb (1)
- Impulsformung (1)
- Impurity Profiling (1)
- Inbreeding depression (1)
- Inequality (1)
- Influenza (1)
- Information Extraction (1)
- Informationsverarbeitung (1)
- Injuries (1)
- Innere Uhr (1)
- Innervation (1)
- Insect (1)
- Insekt (1)
- Instrumentelle Analytik (1)
- Insulin-like Growth Factor (1)
- Integrated circuit (1)
- Integriert-optisches Bauelement (1)
- Integrodifferentialgleichung (1)
- Interactome (1)
- Interaktion (1)
- Intergenerational income mobility (1)
- Intergenerative Einkommensmobilität (1)
- Interleukin 6 (1)
- Interleukine (1)
- Internet der Dinge (1)
- Intervention (1)
- Intestinal Intraepithelial Lymphocy (1)
- Intestinal stem cell (1)
- Intragenerational wage mobility (1)
- Intragenerative Lohnmobilität (1)
- Intrinsic charm (1)
- Invertebrate vision (1)
- IoT (1)
- Ion channel function (1)
- Ionenkanal (1)
- Iridium bis(phosphinite) pincer complexes (1)
- Iridiumkomplexe (1)
- Ischemic stroke (1)
- Isocrates (1)
- Itinerare (1)
- Itineraries (1)
- J- and H-Aggregate (1)
- J- and H-Aggregates (1)
- JNK (1)
- Jacobian matrix (1)
- Jmjd6 (1)
- Josephson junction (1)
- K* µ+μ− (1)
- KDIGO (1)
- Karte (1)
- Katalyse (1)
- Kation (1)
- Kirchhoff's law (1)
- Klima (1)
- Kloosterman sum (1)
- Klotho-related molecules (1)
- Knochenersatz (1)
- Knochenmark (1)
- Knochenzemente (1)
- Knockout (1)
- Knockout <Molekulargenetik> (1)
- Knorpel (1)
- Kohlendioxid (1)
- Kohlenstoff-Nanoröhre (1)
- Kohärente Kontrolle (1)
- Kohärente Multidimensionale Spektroskopie (1)
- Kommunikation (1)
- Kommunikationsprotokoll (1)
- Kompetenzen im Hochschulsektor (1)
- Komplexauge (1)
- Komplexität (1)
- Kontrollierte Wirkstofffreisetzung (1)
- Korrekt gestelltes Problem (1)
- Korrelative Mikroskopie (1)
- Krebs <Medizin> (1)
- Krebsimmuntherapie (1)
- Kritische Infrastruktur (1)
- Kultur (1)
- Kupfer katalyse (1)
- Kupplungsreaktion (1)
- LAD (1)
- LASP1 (1)
- LASP2 (1)
- LHS (1)
- Labor Mobility (1)
- Laguerre-Gauss (1)
- LamB (1)
- Lambdoide Prophagen (1)
- Landnutzung (1)
- Landsat (1)
- Landwirtschaft (1)
- Large detector systems for particle and astroparticle physics (1)
- Laser Pulse Shaping (1)
- Laser scanning (1)
- Laserimpulsformung (1)
- Lasermode (1)
- Latimeria menadoensis (1)
- Leaf (1)
- Leaf cutting ants (1)
- Leishmania (1)
- Lepton (1)
- Leptons (1)
- Lewis acids (1)
- Lgr5 (1)
- Lidar (1)
- Ligand (1)
- Ligand <Biochemie> (1)
- Light (1)
- Linagliptin (1)
- Linked Data (1)
- Lithography (1)
- Localization (1)
- Locked-in-Syndrom (1)
- Logik (1)
- Lolium perenne (1)
- Long-term follow-up (1)
- Lower Reference Value (1)
- Lu-177 (1)
- Lumineszenz (1)
- Lutetium (1)
- Lymphoma (1)
- Löslichkeit (1)
- MAC Protocol (1)
- MDD (1)
- MDR1 (1)
- ME/CFS (1)
- MIP-1β (1)
- MIPs (1)
- MPI (1)
- MRR1 (1)
- MRT (1)
- MS (1)
- MUD (1)
- MYC (1)
- Maccabees (1)
- Machine Learning (1)
- Machzahl (1)
- Macroscopic transport (1)
- Magnetfeldeffekt (1)
- Magnetic Resonance Spectroscopy Imaging (1)
- Magnetic Topological Insulator (1)
- Magnetic resonance (1)
- Magnetic resonance imaging (1)
- Magnetische Resonanz (1)
- Magnetresonanztomografie (1)
- Majorana bound state (1)
- Malaria (1)
- Malignancies (1)
- Malvaviscus arboreus (1)
- Manisch-depressive Krankheit (1)
- Marine sponge-derived actinomycetes (1)
- Marine sponges (1)
- Markarian 501 (1)
- Marrow (1)
- Maschinelles Lernen (1)
- Mass Spectrum (1)
- Masse (1)
- Materials chemistry (1)
- Mathematisches Modell (1)
- Measuring masses (1)
- Mechanisms (1)
- Mechanistic model (1)
- Medicago truncatula (1)
- Medullärer Schilddrüsenkrebs (1)
- Megakaryocyte (1)
- Megakaryocytes (1)
- Megakaryozyt (1)
- Mehrgitterverfahren (1)
- Meiose (1)
- Meiosis (1)
- Melanom (1)
- Melanoma (1)
- Melt electrospinning (1)
- Membranlipide (1)
- Men (1)
- Mensch (1)
- Mensch-Maschine-Interaktion (1)
- Mensch-Maschine-Kommunikation (1)
- Merkel cell carcinoma (1)
- Merkelzellkarzinom (1)
- Merogone experiments (1)
- Mesenchymal Stem Cell (1)
- Mesenchymal Stromal Cells (1)
- Mesogen (1)
- Metabolismus (1)
- Metabolomic Imaging (1)
- Metabolomics (1)
- Metallorganische Chemie (1)
- Metallosupramolekulare Chemie (1)
- Metanephrine (1)
- Metapleural gland (1)
- Metarhizium anisopliae (1)
- Methotrexate (1)
- Metrics (1)
- MicroRNAs (1)
- Minimally invasive vascular intervention (1)
- Mitgliedsstaaten (1)
- Mitochondria (1)
- Mitochondrium (1)
- MitraClip (1)
- Mobility (1)
- Mobilität (1)
- Mode propagation (1)
- Model comparison (1)
- Model simulation (1)
- Modellierung (1)
- Modenpropagation (1)
- Molecular biology (1)
- Molecular biophysics (1)
- Molecular neuroscience (1)
- Molecularly targeted therapy (1)
- Molekülzustand (1)
- Monetary Policy (1)
- Monocytes and macrophages (1)
- Motiliät (1)
- Motion detection (1)
- Motivation (1)
- Motivationspsychologie (1)
- Mrr1 (1)
- Multi-Hop Topologie (1)
- Multi-Hop Topology (1)
- Multicellular aggregates (1)
- Multifunctionalisability (1)
- Multiple Traits (1)
- Multipolar mitosis (1)
- Multizellulären Bakteriengemeinschaften (1)
- Muscidifurax (1)
- Muskelatrophie (1)
- Muskelzelle (1)
- Mutagenese (1)
- Mycobacterium tuberculosis (1)
- Mycobacterium tuberculosis InhA (1)
- Myokarditis (1)
- Myositis (1)
- N-MYC (1)
- N-heterocyclic carbenes (1)
- N6-methyladenosine (1)
- ND10 complex (1)
- NIR-Spektroskopie (1)
- NK cells (1)
- NNLO (1)
- NOS-I (1)
- NOS1AP (1)
- NOX-Inhibitoren (1)
- NP-schweres Problem (1)
- NRF2 (1)
- NT-proBNP (1)
- NTHi (1)
- NaV1.9. oxidized phospholipids (1)
- Nahrungsaufnahme (1)
- Nanooptik (1)
- Nanopartikel (1)
- Nanoporöser Stoff (1)
- Nanosegregation (1)
- Nanostruktur (1)
- Nash-Gleichgewicht (1)
- Nasonia (1)
- Naturgefahr (1)
- Naturkatastrophe (1)
- Navigation analysis (1)
- Neostriatum (1)
- Nerve fibers (1)
- Nerve growth-factorcopy (1)
- Nestbau (1)
- Network Function Virtualization (1)
- Netzhaut (1)
- Netzwerktopologie (1)
- Neuroanatomie (1)
- Neurobiologie (1)
- Neurobiology (1)
- Neurodevelopment (1)
- Neuroendocrine (1)
- Neuroendocrine Tumor (1)
- Neurogenese (1)
- Neuronale Plastizität (1)
- Neutrino (1)
- Neutrino Telescope (1)
- Neutrino detectors (1)
- Neutrophils (1)
- Nichtlineares System (1)
- Nickelkomplexe (1)
- Niederdimensionales Elektronengas (1)
- Nierenfunktionsstörung (1)
- Non-coding RNA (1)
- Non-viral genome engineering (1)
- Nonlinear systems (1)
- Normetanephrine (1)
- Nosocomial Infections (1)
- Nosokomiale Infektionen (1)
- Notch1 (1)
- Notenbank (1)
- Nuclear (1)
- Nucleus accumbens (1)
- Numerical Methods (1)
- Numerical analysis (1)
- OCT1 (1)
- OPT (1)
- OSM (1)
- OSMR (1)
- Oberflächenplasmon (1)
- Oberflächenzustand (1)
- Obstruktive Ventilationsstörung (1)
- Olfaction (1)
- Oligomere (1)
- Oligomers and Polymers (1)
- Omega-3-Fettsäuren (1)
- Oncology (1)
- Oncostatin M (1)
- OncotypeDX\(^{®}\) (1)
- Onkogen (1)
- OpenFlow (1)
- OpsA (1)
- Optical spectroscopy (1)
- Optimale Steuerung (1)
- Optimierung (1)
- Optimierungsproblem (1)
- Optische Eigenschaft (1)
- Organische Synthese (1)
- Organometallic chemistry (1)
- Oryza sativa (1)
- Osmia (1)
- Osteoarthritis (1)
- P(P)over-bar collicions (1)
- P300 (1)
- PABPs (1)
- PAI-1 (1)
- PB-PB Collisions (1)
- PCI-32765 (1)
- PDE (1)
- PEST (1)
- PF-05231023 (1)
- PKA (1)
- PKC (1)
- PKCζ, (1)
- PML (1)
- PML nuclear-bodies (1)
- PMMA bone cement (1)
- PMNs (1)
- PP Collicions (1)
- PSMA (1)
- PSMA-RADS (1)
- PSMA-RADS-3A (1)
- PSMA-RADS-3B (1)
- PSMA-targeted PET (1)
- Paenibacterin (1)
- Pain (1)
- Pair Production (1)
- Pair Prodution (1)
- Pair-Production (1)
- Pan1 (1)
- Pancreas (1)
- Panel-Data Econometrics (1)
- Panelanalyse (1)
- Panic Disorder (1)
- Paniksyndrom (1)
- Paraganglioma (1)
- Parasite development (1)
- Parkinson disease (1)
- Parkinson's disease (1)
- Parkinsonism (1)
- Parkinson’s disease (1)
- Partial Agonists (1)
- Partialagonismus (1)
- Particle dark matter (1)
- Particle production (1)
- Particle properties (1)
- Parton Ditributions (1)
- Pathogenität (1)
- Pathway (1)
- Peinlichkeit (1)
- Peptide (1)
- Period (1)
- Permeability (1)
- Permeabilität (1)
- Perturbative QCD (1)
- Pflanzen (1)
- Pflanzenbildgebung (1)
- Pharmaceutical Analysis (1)
- Phase Transition (1)
- Phospholipase D (1)
- Phospholipide (1)
- Phosphorescence (1)
- Photochemie (1)
- Photochemistry (1)
- Photoelektronenspektroskopie (1)
- Photon detectors for UV, visible and IR photons (vacuum) (1)
- Photons (1)
- Physiologically based kinetic models (1)
- Phänomenologische Soziologie (1)
- Plasmon (1)
- Plasmonic (1)
- Platelet (1)
- Plus (1)
- Plus Plus (1)
- Pollen (1)
- Pollinators (1)
- Poly(2-oxazolin)e (1)
- Poly(2-oxazoline)s (1)
- Poly(glycidol) (1)
- Polyatomare Verbindungen (1)
- Polycyclic aromatic hydrocarbons (1)
- Polycyclische Aromaten (1)
- Polyethylene glycol (1)
- Polyethylenglycol (1)
- Polypeptoide (1)
- Polypeptoids (1)
- Polysaccharide intercellular adhesin (PIA) (1)
- Polyspermy (1)
- Porphyrin (1)
- Positronenemissionstomografie (1)
- Post-transcriptional regulation (1)
- Postmarketing Experience (1)
- Practitioner's guide (1)
- Praktische Theologie (1)
- Preclinical (1)
- Prediction (1)
- Predictions (1)
- Preference for redistribution (1)
- Prevalence (1)
- Probiotikum (1)
- Production Cross-Section (1)
- Production cross-section (1)
- Prognostic impact (1)
- Programm (1)
- Progressive Relaxation (1)
- Proliferation (1)
- Propositional processing (1)
- Propositionale Verarbeitung (1)
- Prostatakrebs (1)
- Prostate cancer diagnostics (1)
- Protein (1)
- Protein folding (1)
- Protein kinase D1 (PKD1) (1)
- Proteinkinasen (1)
- Proteom (1)
- Proton-Proton- Collisions (1)
- Protonen-NMR-Spektroskopie (1)
- Protopterus annectens (1)
- Prototype (1)
- Pseudorapidity (1)
- Psychiatric disorders (1)
- Psychische Störung (1)
- Psychologie (1)
- Pteromalidae (1)
- Pump-Probe Technik (1)
- Pump-Probe-Technik (1)
- Punktwolke (1)
- Pyrenderivate (1)
- Pyrene (1)
- Pyrrolidinderivate (1)
- Pyrrolidine carboxamides (1)
- QCD Corrections (1)
- QoE Monitoring (1)
- Quality of Experience (1)
- Quanteninformatik (1)
- Quantentheorie (1)
- Quantum Spin Hall Effect (1)
- Quantum chromodynamics (1)
- Quark (1)
- Quark & gluon jets (1)
- Quark pair procuction (1)
- Quarkonium Production (1)
- Quarks (1)
- Quasi-1D Elektronensysteme (1)
- Quasi-Variational Inequality (1)
- Quasi-Variationsungleichung (1)
- RCT (1)
- REELS (1)
- REST-Complex (1)
- RGB-D (1)
- RNA (1)
- RNA Aptamer (1)
- RNA metabolism (1)
- RNA modification (1)
- RNA polymerase II (1)
- RNA sequencing (1)
- RNA-binding proteins (1)
- RNA-seq (1)
- RNS (1)
- RNase E (1)
- RSK (1)
- Ra-224 (1)
- Radiation calculations (1)
- Radionuclide Therapy (1)
- Radiotherapy (1)
- Raphe Kerne (1)
- Rapidity (1)
- Rashba effect (1)
- Rastertunnelmikroskopie (1)
- Raumdaten (1)
- Raumfüllung (1)
- Raumverhalten (1)
- Re-Annotation (1)
- Re-annotation (1)
- Reaction kinetics and dynamics (1)
- Receptors (1)
- Refugee Crisis (1)
- Registration (1)
- Regularisierung (1)
- Regulator of G protein signaling 2 (1)
- Regulatorischer Fokus (1)
- Regulatory T cells (1)
- Regulatory focus (1)
- Rekonstruktion (1)
- Relative Entropy (1)
- Release system (1)
- Remote Sensing (1)
- Renal abnormalities (1)
- Repair (1)
- Research design (1)
- Reservoir Strain (1)
- Resiliente Stadt (1)
- Resilienz (1)
- Resistance (1)
- Rezeptor (1)
- Rgs2 (1)
- Rho-Proteine (1)
- RhoGTPase (1)
- Rhodacyclopentadiene (1)
- Rhodobacter sphaeroides (1)
- Risikoanalyse (1)
- Risikomanagement (1)
- Risk assessment (1)
- Risk-factors (1)
- Ritual (1)
- River Basins (1)
- Robotics (1)
- Robotik (1)
- Root s=7 (1)
- Root-S=13 TEV (1)
- Rowing Ergometer (1)
- Ruthenium Komplexe (1)
- Räumliches Verhalten (1)
- Röntgen-Kleinwinkelstreuung (1)
- Röntgenstrukturanalyse (1)
- S1PR2 (1)
- SDN (1)
- SDN Controllers (1)
- SDN Switches (1)
- SIM (1)
- SLC2A3 (1)
- SNP (1)
- SNP-microarray (1)
- SOCE (1)
- SSTR-PET (1)
- STIM1 (1)
- STIM2 (1)
- SWOT (1)
- Scale (1)
- Schafgarbe <Gattung> (1)
- Schilddrüse (1)
- Schlaf (1)
- Schlaganfall (1)
- Schleuderguss (1)
- Schmerz (1)
- Schwann-cells (1)
- Science history (1)
- Sea urchin development (1)
- Selbst (1)
- Selbstorganisation (1)
- Semantic Search (1)
- Semantic Technologies (1)
- Semantic cognition (1)
- Semantische Analyse (1)
- Semantische Verarbeitung (1)
- Sensorimotor Rhythms (1)
- Sequenzanalyse <Chemie> (1)
- Serotonerge Nervenzelle (1)
- Serotonin (1)
- Sesquiterpene lactones (1)
- Sesquiterpenlactonen (1)
- Sglt1 (1)
- Shaggy kinase (1)
- Shiga toxin producing E. coli (1)
- Shigella flexneri (1)
- Shin-Metiu Model (1)
- Showers (1)
- Siberian spurge (1)
- Silibinin (1)
- Silibinin ester (1)
- Simulation methods and programs (1)
- Simulator (1)
- Single-Photon Detectors (1)
- Single-Photon-Emissions-Computertomographie (1)
- Single-molecule fluorescence microscopy (1)
- Sleeping Beauty transposon (1)
- Small RNA (1)
- Smart User Interaction (1)
- SnRK1 (1)
- Social Media (1)
- Social neuroscience (1)
- Society (1)
- Software (1)
- Software Defined Networking (1)
- Sonogashira (1)
- Sonogashira coupling (1)
- Sonogashira-Hagihara-Reaktion (1)
- Sox5 (1)
- Soziale Insekten (1)
- Soziale Mobilität (1)
- Sozialstaat (1)
- Soziologie (1)
- Sozioökonomisches System (1)
- Space filling (1)
- Sparse Sampling (1)
- Spatial behavior (1)
- Spatiotemporal analysis (1)
- Species Traits (1)
- Sphingomyelinase (1)
- Spinal nerves (1)
- Spinkette (1)
- Spintronik (1)
- Spleen tyrosine kinase (1)
- Spontaneous symmetry breaking (1)
- Sprue (1)
- Squarain Farbstoffe (1)
- Squaraine Dyes (1)
- Stability (1)
- Stabilität (1)
- Standardisierung (1)
- Staphylococcus epidermidis (1)
- Star-shaped poly(ethylene glycol) (1)
- States (1)
- Statistical misconception (1)
- Statistische Hypothese (1)
- Stickstoffmonoxid-Synthase (1)
- Stiffness (1)
- Stimulating factor (1)
- Stofftransport <Biologie> (1)
- Strain Assessment (1)
- Stress-Syndrom (1)
- Stressresistenz (1)
- Strong interaction (1)
- Structure-based (1)
- Strömung (1)
- Student (1)
- Super-resolution microscopy (1)
- Superpartners (1)
- Supraleitung (1)
- Supramolecular Chemistry (1)
- Surface plasmon (1)
- Surgery (1)
- Sustainability (1)
- Symmetries (1)
- Synaptische Proteine (1)
- Synaptonemal complex (1)
- Synovial Fluid Aspiration (1)
- Synthese (1)
- System (1)
- T cell acute lymphoblastic leukemia (1)
- T helper 1 cells (1)
- T-ALL (1)
- T-Lymphozyt (1)
- T-cell engineering (1)
- T-cell responses (1)
- T-cell therapy (1)
- T-lymphocytes (1)
- T. brucei (1)
- TAB08 (1)
- TFIIIC (1)
- TGF-β3 (1)
- TGN1412 (1)
- TK6 cells (1)
- TKI (1)
- TMJ (1)
- TRDV2 (1)
- TRGV9 (1)
- TRPA1 (1)
- TRPV1 (1)
- Tagesrhythmik (1)
- Talbot–Lau interferometer (1)
- Targeted Therapies (1)
- Targeted drug delivery (1)
- Targeted therapies (1)
- Tau leptons (1)
- Tauola (1)
- Taurolidine (1)
- Technical Documentation (1)
- Technische Unterlage (1)
- Testing parameter difference (1)
- Tetrazoliumsalze (1)
- Thalamic nuclei (1)
- Themenpark (1)
- Theologie (1)
- Theoretical Chemistry (1)
- Theoretische Chemie (1)
- Therapy (1)
- Thermografie (1)
- Thioether-Poly(glycidol) (1)
- Thrombopoese (1)
- Thrombopoiesis (1)
- Thrombosis (1)
- Thrombozytenaggregation (1)
- Tian Shan (1)
- Tiermodell (1)
- Time Series Analyses (1)
- Time-Resolved Spectroscopy (1)
- Timeless (1)
- Tiotropium (1)
- Tissue Engineering (1)
- Tissue engineering (1)
- Tn1549 transposon (1)
- Tn916-like transposon family (1)
- To-leading order (1)
- Tool (1)
- Top physics (1)
- Topological insulators (1)
- Training (1)
- Traits-Environment Relationships (1)
- Transkription (1)
- Transkription <Genetik> (1)
- Transkriptionsfaktor (1)
- Transkriptom (1)
- Translational research (1)
- Transparent motion (1)
- Transpiration barrier (1)
- Transporters (1)
- Transportkoeffizient (1)
- Transportprozess (1)
- Transposon (1)
- Transverse-momentum (1)
- Treatment (1)
- Treatment outcome (1)
- Trichomalopsis (1)
- TrkB (1)
- Tropomyosin receptor kinase B (1)
- Trypanosoma (1)
- Trypanosoma brucei brucei (1)
- Trypanosomes (1)
- Tuberkelbakterium (1)
- Tumor Microenvironment (1)
- Tumour angiogenesis (1)
- Tunnelspektroskopie (1)
- Two-dimensional Spectroscopy (1)
- UAV (1)
- UV-VIS-Spektroskopie (1)
- UV/Vis spectroscopy (1)
- UWB (1)
- Ultrafast information processing (1)
- Ultrakurzer Lichtpuls (1)
- Ultraschnelle Informationsverarbeitung (1)
- Ultraschnelle Photochemie (1)
- Umverteilungspräferenz (1)
- Universität Würzburg. Lehrstuhl für Pharmazeutische Technologie und Biopharmazie (1)
- Urbane Resilienz (1)
- Ureaplasma species (1)
- Usage (1)
- Utility (1)
- V800 (1)
- VEMP (1)
- VSG (1)
- VSMC (1)
- Valvular heart-desease (1)
- Variables Oberflächen Glycoprotein (1)
- Variant surface glycoprotein (1)
- Variationsungleichung (1)
- Varieties of Democracy (1)
- Venusfliegenfalle (1)
- Verallgemeinertes Nash-Gleichgewichtsproblem (1)
- Vergütung (1)
- Verhalten (1)
- Verkehrspsychologie (1)
- Verteilungspolitik (1)
- Viral infections (1)
- Virtualisierung (1)
- Viscosity (1)
- Voltage-Clamp-Methode (1)
- Vγ9Vδ2 (1)
- WTAP (1)
- Wasser Fett Trennung (1)
- Wasseroxidation (1)
- Weakly interacting massive particles (1)
- Web navigation (1)
- Well-Balanced (1)
- Well-posedness (1)
- Wellenleiter (1)
- Westafrika (1)
- Wild bees (1)
- Wire relaxation (1)
- Wirkstofffreisetzung (1)
- Wirtschaftsentwicklung (1)
- Wirtschaftsstruktur (1)
- Wirtschaftswachstum (1)
- Wissenschaftliche Literatur (1)
- Währungsunion (1)
- X-ray imaging (1)
- XPS (1)
- Xenophon (1)
- Xenopus laevis oocytes (1)
- Z Boson (1)
- ZDF rats (1)
- ZO-1 (1)
- Zahlentheorie (1)
- Zeitaufgelöste Spektroskopie (1)
- Zeitauflösung (1)
- Zellbiologie (1)
- Zelldifferenzierung (1)
- Zelloberfläche (1)
- Zellteilung (1)
- Zika virus (1)
- Zinsänderungsrisiko (1)
- Zwei-Prozess-Modell (1)
- Zweidimensionale Spektroskopie (1)
- [68Ga]DOTATOC (1)
- \(^{18}\)F-FDG (1)
- \(^{18}\)F-fluorodeoxyglucose (1)
- \(^{99m}\)Tc-MAG3 (1)
- ab initio calculations (1)
- absorbed dose (1)
- absorbed dose to the blood (1)
- acetone (1)
- acquisition of host regulators (1)
- acrophobia (1)
- action potentials (1)
- activators/inhibitors of phosphorylation (1)
- active galactic nuclei (1)
- activity rhythms (1)
- activity tracker (1)
- acute lymphocytic leukaemia (1)
- acute myeloid leukemia (1)
- adaptive role (1)
- additive manufacturing (1)
- adrenal insufficiency (1)
- adsorption (1)
- adsorption-induced deformation (1)
- adult (1)
- adult treatment (1)
- advanced drug delivery system (1)
- aerobic fitness (1)
- aerobic training (1)
- affect (1)
- age-related macular degeneration (1)
- agricultural intensity (1)
- agricultural productivity (1)
- agroecology (1)
- airborne laser scanning (ALS) (1)
- airflow (1)
- alcohol (1)
- alkaloids (1)
- allogeneic stem cell transplantation (1)
- allosterism (1)
- allotype (1)
- alpha particles (1)
- alpha-synuclein (1)
- altruism (1)
- altruistic compensation (1)
- altruistic punishment (1)
- aluminum copper alloys (1)
- amino acid analysis (1)
- amount of invested mental effort (1)
- amygdala (1)
- anaphylatoxins (1)
- anemia (1)
- aneurysm (1)
- anger (1)
- angiotensin II type 1 receptor (1)
- animal behaviour (1)
- anti-hiv agents (1)
- anti-infective vaccination (1)
- anti-inflammatory (1)
- anti-microbial activit (1)
- anti-retroviral agents (1)
- antibacterial activity (1)
- antibiotic resistance (1)
- anticoagulants (1)
- anticoagulation (1)
- antidepressant (1)
- antigenic recall (1)
- antimicrobials (1)
- antioxidants (1)
- anuria (1)
- aphasia (1)
- approximation algorithm (1)
- aqua material (1)
- arachidonic acid metabolic network (1)
- arial fibrillation (1)
- arousal (1)
- arrhythmia (1)
- arterial hypotension (1)
- artificial diet (1)
- artificial intelligence (1)
- aspergillosis (1)
- assay (1)
- assessment of cognitive disorders/dementia (1)
- assortative mating (1)
- asymmetry (1)
- athletes (1)
- atmospheric chemistry (1)
- atomistic models (1)
- atrial fibrillation (1)
- attention (1)
- attention bias (1)
- attention-deficit/hyperactivity disorder (1)
- atypical chemokine receptor 3 (1)
- autoantibodies (1)
- autoimmune antibodies (1)
- autoimmunity (1)
- autologous stem cell transplantation (1)
- automated driving (1)
- autosomal recessive non-synstromic hearing loss (1)
- auxin (1)
- axonal degeneration (1)
- bPAC (1)
- bSSFP (1)
- bZIPs (1)
- bacteria (1)
- bacterial genomics (1)
- bacterial transcription (1)
- bakanae (1)
- balanced steady state free precession (1)
- bank credit market (1)
- banking (1)
- bariatric surgery (1)
- barium titanate (1)
- bee disease (1)
- beech forests (1)
- behavior (1)
- behavioral conditioning (1)
- behavioral rhythms (1)
- behavioral transition (1)
- behaviour (1)
- behaviour therapy (1)
- bi-compartmental (1)
- bi-compartmental knee arthoplasty (1)
- big data (1)
- bile (1)
- bioactive peptide (1)
- bioassay-guided fractionation (1)
- bioassays (1)
- bioconjugation (1)
- biodegradable implant (1)
- biodiversity (1)
- biodiversity estimation (1)
- biofabrication (1)
- biofeedback (1)
- biogeochemistry (1)
- biokinetics (1)
- biological dosimetry (1)
- biological pest control (1)
- biologics (1)
- biomedical applications (1)
- biomedical engineering (1)
- biomedicine (1)
- bioprinting (1)
- bioreactor (1)
- bioresponsive (1)
- bird diversity (1)
- bitopic ligand (1)
- black woodpecker (1)
- blocking opsonization (1)
- blood (1)
- blood glucose regulation (1)
- blood-nerve barrier (1)
- body composition (1)
- bond activation (1)
- bond market (1)
- bone development (1)
- bone marrow niche (1)
- bone morphogenetic protein (1)
- boron chains (1)
- boronium cations (1)
- borylation (1)
- borylenes (1)
- brain (1)
- brain metastasis (1)
- brain stimulation (1)
- brood rearing (1)
- building behavior (1)
- butyrophilin 3 (1)
- butyrophilins (1)
- cAMP (1)
- caffeine (1)
- calcium phosphate (1)
- calcium phosphate cement (1)
- cancer genomics (1)
- cancer immunotherapy (1)
- cancer models (1)
- cancer risk (1)
- candidalysin (1)
- canonical microcircuits (1)
- capecitabine (1)
- capsaicin (1)
- carabid beetles (1)
- carbanion (1)
- carbene-stabilized nickel complexes (1)
- carbohydrates (1)
- carbon fiber reinforcement (1)
- cardiac device therapy (1)
- cardiac hypertrophy (1)
- cardiac innervation imaging (1)
- cardiac nerve (1)
- cardiac surgery (1)
- cardiac sympathetic nerve system (1)
- cardiac sympathetic nervous system (1)
- cardiomyopathy (1)
- cardiovascular disease (1)
- cardiovascular morbidity (1)
- cardiovascular mortality (1)
- career self-management (1)
- careers (1)
- carmine (1)
- cartilage tissue engineering (1)
- catalysis (1)
- cataracts (1)
- ceftriaxone (1)
- cell growth (1)
- cell membranes (1)
- cell wall channel (1)
- cell wall synthesis (1)
- cellular neuroscience (1)
- cellular stress responses (1)
- cellular waveform (1)
- center of pressure (1)
- centrifugally casting (1)
- ceramides (1)
- chain structures (1)
- chalcogens (1)
- channel (1)
- chelates (1)
- chemical bonding (1)
- chemical communication (1)
- chemical ecology (1)
- chemical modification (1)
- chemotherapy (1)
- child (1)
- children/adults (1)
- chlamydia (1)
- chlamydia serine proteases (1)
- chlamydial inclusion (1)
- chlamydomonas reinhardtii (1)
- chlamyopsin (1)
- cholinergic system (1)
- chromatin (1)
- chronic constriction injury (1)
- chronophin (1)
- cicatricial pemphigoid (1)
- circadian clocks (1)
- cirrhosis (1)
- claudin-1 (1)
- click chemistry (1)
- climate change (1)
- climate control (1)
- climate scenarios (1)
- climate-change (1)
- clinical genetics (1)
- co-delivery (1)
- coaptation line (1)
- cochlear nucleus (1)
- coevolution (1)
- cofilin (1)
- cognition (1)
- cognitive balance (1)
- cognitive dissonance (1)
- cognitive neuropsychology in dementia (1)
- coherence (1)
- cohesin (1)
- collagen-glycosaminoglycane matrix (CGM) (1)
- colon cancer (1)
- color vision (1)
- coloration (1)
- comparison (1)
- complement (1)
- complement system (1)
- complex (1)
- complexity (1)
- complications (1)
- compound eyes (1)
- compressive strength (1)
- computational modelling (1)
- conditional sex allocation (1)
- conditioned response (1)
- condyle pathomorphology (1)
- conical intersections (1)
- conjugated polymers (1)
- conjugative transposition (1)
- conjunctival defect (1)
- conjunctival hole (1)
- conjunctival repair (1)
- consciousness (1)
- content cluster (1)
- content-analysis (1)
- control-focused democracy (1)
- convergent star product (1)
- copeptin (1)
- copy number variation (1)
- corneal endothelium (1)
- corneal epithelium (1)
- corneal storage (1)
- coronary artery disease (1)
- correlative methods (1)
- costs (1)
- crop (1)
- crop diversity (1)
- cross-talk (1)
- cryostructuring (1)
- cryptochrome (1)
- crystal structure (1)
- crystallography (1)
- culturable command area (1)
- cyclic (alkyl)(amino) carbenes (1)
- cycloaddition (1)
- cylic GMP (1)
- cystic fibrosis (1)
- cytarabine dose (1)
- cytokine (1)
- cytokine secretion (1)
- cytotoxic T cells (1)
- dMyc (1)
- dSTORM (1)
- dabrafenib (1)
- damage tolerant cement (1)
- darkfield imaging (1)
- data science (1)
- dead spot (1)
- dead tree (1)
- deadwood (1)
- debris-covered glaciers (1)
- decay (1)
- decision making (1)
- defense (1)
- deformation (1)
- deformation quantization (1)
- delayed cerebral infarction (1)
- democracy (1)
- density functional theory (1)
- deoxyribozymes (1)
- depolarization (1)
- derivatives (1)
- dermatology (1)
- desymmetrization (1)
- device-related infections (1)
- diabetes (1)
- diabetes insipidus (1)
- diabetes mellitus (1)
- diabetic cardiomyopathy (1)
- diagnosis (1)
- diboranes (1)
- diboration (1)
- diboron (1)
- diboryne (1)
- dietary approaches to stop hypertension (1)
- differentiation (1)
- digitalization (1)
- dilatometer (1)
- direct anterior approach (1)
- disease genetics (1)
- disfluency (1)
- dispersal (1)
- distal radio-ulnar joint (1)
- distance measurement (1)
- distributary (1)
- distribution modulo one (1)
- dmP53 (1)
- dog microbiome (1)
- dogs (1)
- dorsal instrumentation (1)
- dosimetry (1)
- double-strand DNA breaks (1)
- double-stranded (1)
- drainage tube (1)
- driver behavior (1)
- driver distraction (1)
- drug design (1)
- drug discovery (1)
- drug regulation (1)
- drug-induced immune hemolytic anemia (1)
- dry lung syndrome (1)
- dualsteric ligand (1)
- dyes (1)
- dynamic (1)
- eHealth (1)
- early neural precursors (1)
- early-life stress (1)
- eco-metabolomics (1)
- ecological intensification (1)
- ecology (1)
- economics (1)
- ecosystem services (1)
- educational psychology (1)
- educational tool (1)
- efficacy (1)
- egalitarian democracy (1)
- elderly (1)
- electrical and electronic engineering (1)
- electrocatalysis (1)
- electroencephalogram (1)
- electrometer (1)
- electronic and spintronic devices (1)
- electronic devices (1)
- electrophiles (1)
- elektronisch angeregte Zustände (1)
- elution (1)
- emergence (1)
- emotion processing (1)
- emotion regulation (1)
- endocytosis (1)
- endometriosis (1)
- endophytic fungi (1)
- endophytische Pilze (1)
- endoreplication (1)
- endothelial cells (1)
- endovascular repair (1)
- energy metabolism (1)
- energy transfer (1)
- enoyl ACP reductase (1)
- entrepreneurship (1)
- entropy inequality (1)
- environmental degradation (1)
- environmental sciences (1)
- enzyme activator (1)
- episcleral drainage device (1)
- erovalent diboron compounds (1)
- error estimate (1)
- erythrocyte adherence (1)
- evaluation (1)
- event (1)
- evolutionary genetics (1)
- exaptation (1)
- exclusion criteria (1)
- exercise intervention (1)
- expansion (1)
- experience taking (1)
- experimental evolution (1)
- expression (1)
- extended Kalman filter (1)
- extinction (1)
- extra cellular matrix (1)
- extremity trauma (1)
- eye tracking (1)
- eyetracking (1)
- fMRI (1)
- failure (1)
- fast decay (1)
- fatigue (1)
- fear behavior (1)
- fear conditioning (1)
- feral honey bees (1)
- fermentation (1)
- ferroelectrics and multiferroics (1)
- ferroptosis (1)
- fiber–matrix interaction (1)
- fibroblast growth factor (1)
- field testing (1)
- finite volume method (1)
- flagellate (1)
- flame test (1)
- fluorescent protein (1)
- fluorescent resonance energy transfer (1)
- flupyradifurone (1)
- flux distributions (1)
- flytrap (1)
- foliar fungal community (1)
- food security (1)
- foreign companies (1)
- fracture (1)
- fracture-associated vascular damage (1)
- free energy (1)
- frequency modulation (1)
- frontal cortex (1)
- frontotemporal dementia (1)
- frühe neurale Vorläufer (1)
- fullerene network (1)
- functional genetics (1)
- functional genomics (1)
- functional mitral regurgitation (1)
- functional near-infrared spectroscopy (1)
- functional regurgitation (1)
- functional training (1)
- fungal biology (1)
- fungal endophytes (1)
- fungal rhodopsins (1)
- fungicidal activity (1)
- fungus-farming insects (1)
- fungus-plant interaction (1)
- gametogenesis (1)
- gamma gamma channel (1)
- gastric cancer (1)
- gels and hydrogels (1)
- gender gap (1)
- gene expression (1)
- gene transfer (1)
- gene-expression (1)
- genetic association study (1)
- genetic linkage study (1)
- genome annotation (1)
- genome evolution (1)
- genomic instability (1)
- genotype (1)
- genotype-phenotype patterns (1)
- genotyping arrays (1)
- germinal center (1)
- germline mutations (1)
- glaciers (1)
- glaucoma drainage device (1)
- glioblastoma multiforme (1)
- glioma (1)
- glucocerebrosidase mutation (1)
- glucose transporter (1)
- glycoprotein GPV (1)
- gp130 (1)
- granulocytes (1)
- graphs (1)
- grating interferometer (1)
- green light perception (1)
- green systems biology (1)
- ground dwelling predators (1)
- groundwater (1)
- group change (1)
- growth hormone deficiency (1)
- growth pattern (1)
- guanylyl cyclase-A (1)
- guidelines (1)
- gut microbiome (1)
- habitat requirements (1)
- habitat suitability model (HSM) (1)
- half-life (1)
- half-sandwich complexes (1)
- halothane (1)
- hardness (1)
- health care payers (1)
- health promotion (1)
- healthy volunteers (1)
- heart failure with mid-range ejection fraction (1)
- helminths (1)
- hemolysis (1)
- hemorrhagic stroke (1)
- hepatitis C virus (1)
- hereditary breast and ovarian cancer (1)
- hereditary hearing loss (1)
- heterologous (1)
- hibernation (1)
- hierarchical matrix (1)
- high performance liquid chromatography (1)
- high-intensity interval training (1)
- hip (1)
- hippocampus (1)
- histones (1)
- history (1)
- hollow tree (1)
- homogeneous catalysis (1)
- honey bees (1)
- host cell damage (1)
- host cell invasion (1)
- host screening (1)
- hub genes (1)
- human behaviour (1)
- human body weight (1)
- human brain microvascular endothelial cells (1)
- human herpesvirus 6 (1)
- human learning (1)
- human microbiome (1)
- human primary cells (1)
- human-automation interaction (1)
- human-computer interaction (1)
- humans (1)
- hyaluronic acid (1)
- hybrid molecules (1)
- hybrid pacemaker (1)
- hydrodynamic limits (1)
- hydrogel (1)
- hydrogenation (1)
- hydrological modelling (1)
- hydroxyephedrine (1)
- hypertension (1)
- hyphae (1)
- hypothalamus (1)
- icaADBC (1)
- identification (1)
- identity integration (1)
- illumina (1)
- image processing (1)
- imaginary quadratic field (1)
- imaging (1)
- imaging and sensing (1)
- iminoboranes (1)
- immersion (1)
- immune cells (1)
- immune reconstitution (1)
- immunoglobulin superfamily (1)
- immunosuppression (1)
- immunotherapy (1)
- impact force (1)
- impervious surface areas (1)
- implant fit (1)
- implant positioning (1)
- implants (1)
- implicit motives (1)
- impulse control disorders (1)
- in situ analysis (1)
- in situ forest monitoring (1)
- in vitro contracture test (1)
- in vitro selection (1)
- in-vitro (1)
- inactivity (1)
- index analysis (1)
- individualised modular treatment programme (1)
- individualized training (1)
- indole-3-acetic acid (IAA) (1)
- indoxyl sulfate (1)
- infinium HumanOmni1-Quad (1)
- inflammation mediators (1)
- inflammatory pain (1)
- information technology (1)
- injectable protein formulation (1)
- injury prevention (1)
- innate immune response (1)
- insect vision (1)
- insect-fungus mutualism (1)
- insecticides (1)
- insertion-site deep sequencing (1)
- insulin receptor (1)
- insulin-like growth factor 1 receptor (1)
- integrated optics (1)
- inter-rater reliability (1)
- interest rate risk (1)
- interface control (1)
- intergenerational contraction (1)
- intergroup bias (1)
- internet of things (1)
- interobserver (1)
- interreader (1)
- intervalence charge transfer (1)
- intervention (1)
- intestinal barrier (1)
- intra-limb anticipatory postural adjustments (1)
- invasive disease (1)
- inventory (1)
- inverse parameterization (1)
- ion channels in the nervous system (1)
- ionizing radiation (1)
- irrigation pricing (1)
- ischemia-reperfusion injury (1)
- ischemic (1)
- ischemic stroke (1)
- islets of Langerhans (1)
- isomers (1)
- jasmonate (1)
- joint aspiration (1)
- juvenile idiopathic arthritis (1)
- ketogenic diet (1)
- ketone bodies (1)
- killing (1)
- kinect (1)
- kinetic description of gases (1)
- knee (1)
- knee alignment (1)
- knee osteoarthritis (1)
- laboratory measurements (1)
- lambda-phages (1)
- laminin 332 (1)
- land surface temperature (1)
- landscape heterogeneity (1)
- laparoscopic right colectomy (1)
- large Stokes shift (1)
- laser scanner (1)
- laserscanner (1)
- latency (1)
- leaf-cutting ants (1)
- leaflet (1)
- learning (1)
- leukocytes (1)
- level of evidence: IV (1)
- levosimendan (1)
- libertarian democracy (1)
- lifetime spectroscopy (1)
- limbic system (1)
- linked open data (1)
- lipid bilayer membrane (1)
- lipid rafts (1)
- lipochitinoligosaccharides (1)
- liquid crystals (1)
- literature review (1)
- liver diseases (1)
- liver oligometastases (1)
- loanable funds theory (1)
- localization microscopy (1)
- locus coeruleus (1)
- locus coerulus (1)
- low Mach number (1)
- low-cost spectrometer (1)
- low-valent main group chemistry (1)
- lymph nodes (1)
- lysosomal storage disorder (1)
- lytic replication (1)
- mHealth (1)
- mRNA (1)
- macrophages (1)
- macrophages immunobiology (1)
- magnesium (1)
- magnetic resonance imaging (1)
- main-group chemistry (1)
- major depression (1)
- major depressive disorder (1)
- malignant hyperthermia (1)
- mapping (1)
- marine biology (1)
- marine sponges (1)
- market entry decisions (1)
- mass (1)
- mass casualties (1)
- mass spectrometry (1)
- master sex-determining gene (1)
- mate recognition (1)
- matrix metalloproteases (1)
- matrix metalloproteinases (1)
- measurement of democracy (1)
- medaka (1)
- medical (1)
- medical genetics (1)
- medical research (1)
- medicinal plants (1)
- medicine authentication tools (1)
- meiosis (1)
- melt electrospinning (1)
- melt electrowriting (1)
- membrane potential (1)
- membrane proteins (1)
- meningitis (1)
- mental disorders (1)
- mental representation (1)
- mesenchymal stem cells (1)
- metabolic modeling (1)
- metabolic pathways (1)
- metabolic profile (1)
- metacognitive control (1)
- metacognitive judgments (1)
- metacognitive monitoring (1)
- metacomprehension (1)
- metagenomics (1)
- metallosupramolecular chemistry (1)
- mevalonate pathway (1)
- miR-146a (1)
- miR-193a (1)
- miR-26 (1)
- miRNA Biogenesis (1)
- micro pattern gaseous detectors (1)
- micro-ionization chambers (1)
- microRNA (1)
- microbial ecology (1)
- microbiome (1)
- microbot (1)
- microdialysis (1)
- microenvironment (1)
- micromegas detectors (1)
- micronuclei (1)
- microrna (1)
- microscopy (1)
- microswimmer (1)
- mild (1)
- milk proteins (1)
- mineralization (1)
- minimal invasive surgery (1)
- minimally invasive (1)
- mitigation strategies (1)
- mitochondrial morphology (1)
- mitral valve (1)
- mixed hearing loss (1)
- mobile apps (1)
- model (1)
- model organism (1)
- modeling (1)
- moderate sedation (1)
- modulation kinetics (1)
- module (1)
- molecular docking (1)
- molecular dynamics (1)
- molecular radiotherapy (1)
- monetary economy (1)
- monitoring (1)
- monoamine oxidase A (1)
- monocyte-platelet aggregates (1)
- mood (1)
- mood induction (1)
- mortality (1)
- motility (1)
- motor control (1)
- mouse (1)
- mouse microbiome (1)
- mouse platelets (1)
- movement ecology (1)
- moycardial sympathetic innervation (1)
- mucous membrane pemphigoid (1)
- multi-fluid mixture (1)
- multi-source forest health monitoring network (1)
- multidrug-resistant bacteria (1)
- multigene-array (1)
- multigrid (1)
- multimodal fusion (1)
- multimodal interface (1)
- multiple bonds (1)
- multiplicity of infection (1)
- muon spectrometer (1)
- muscarinic receptors (1)
- muscle (1)
- mutualism (1)
- mycobacteria (1)
- mycolic acid (1)
- myocardial nerve (1)
- myocardial perfusion imaging (1)
- myocarditis (1)
- nanostructured (1)
- nanowires (1)
- narratives (1)
- natriuretic peptides (1)
- natural interfaces (1)
- natural variation (1)
- navigation (1)
- ncRNA (1)
- near-infrared spectroscopy (1)
- necrosis (1)
- neoepitope-derived peptides (1)
- neonatal renal failure (1)
- nest climate (1)
- net testing effect (1)
- network (1)
- networking (1)
- neural circuits (1)
- neural stem cells (1)
- neuroepithelial progenitors (1)
- neuroepitheliale Vorläufer (1)
- neurogenesis (1)
- neuroinflammation (1)
- neuronal dysfunction (1)
- neuronal nitric oxide synthase (1)
- neuronale Stickstoffmonoxidsynthase (1)
- neuropathic pain (1)
- neuropeptide (1)
- neurophysiology (1)
- neuroprotection (1)
- neuroprotective (1)
- neuropsychiatric disorders (1)
- neuropsychiatrische Störungen (1)
- neurotransmitters (1)
- neutral sphingomyelinase 2 (1)
- neutrophils (1)
- nicht-viraler Gentransfer (1)
- nicotinic receptors (1)
- nine-banded armadillo (1)
- non-coding RNA (1)
- non-nucleoside reverse transcriptase inhibitors (1)
- non-responder (1)
- nonadiabatic dynamics (1)
- norepinephrine (1)
- nuclear role (1)
- nucleic acids (1)
- nucleosides (1)
- nuclesosome positioning (1)
- nucleus accumbens (1)
- null hypothesis testing (1)
- nutrients (1)
- object-based image analysis (1)
- objective assessment (1)
- oesophagogastroduodenoscopy (1)
- olfaction (1)
- oligo-recurrence (1)
- oligohydramnios sequence (1)
- oligometastases (1)
- ologen implant (1)
- omega-3 fatty acids (1)
- oncogenesis (1)
- optical remote sensing (1)
- optimal control (1)
- optimal control problem (1)
- oral anticancer drugs (1)
- organic electronics (1)
- organometallic chemistry (1)
- osmotic stimulation (1)
- osteochondral implant (1)
- outcome (1)
- outpatients (1)
- ovarian cancer (1)
- ovary (1)
- oxidierte Phospholipide (1)
- p-cresyl sulfate (1)
- p-value (1)
- pacemaker neuron (1)
- paediatric cancer (1)
- pancreatic carcinoma (1)
- paraganglioma (1)
- parasite (1)
- parent training (1)
- partial differential equation (1)
- partial integro-differential equations (1)
- partially-supervised (1)
- patch-clamp (1)
- pathogen vector (1)
- patient-doctor-relationship (1)
- patient-specific (1)
- pea aphid (1)
- peak oxygen uptake (1)
- pediatric patients (1)
- peer review (1)
- pelvic trauma (1)
- pemphigoid (1)
- pemphigus (1)
- penetrance (1)
- peptidase inhibitor PI15 (1)
- peptide receptor (1)
- peptide receptor radionuclide therapy (1)
- peptide synthesis (1)
- perception (1)
- percutaneous mitral valve repair (1)
- periodization (1)
- peripheral nervous system (1)
- permeation and transport (1)
- pesticide (1)
- phaeochromocytoma (1)
- phagocytosis (1)
- pharmacology (1)
- phase IV (1)
- phase contrast imaging (1)
- phase stepping (1)
- phase transitions and critical phenomena (1)
- phenological response (1)
- phenological shift (1)
- phenols (1)
- phenotype (1)
- pheochromocytoma (1)
- phosphine ligands (1)
- phosphoantigens (1)
- phospholipase D (1)
- photodynamics (1)
- photoelectron spectroscopy (1)
- photoreceptor (1)
- phototransduction (1)
- phototrophic growth (1)
- phylogenomics (1)
- physical fitness (1)
- phytochemicals (1)
- pi-conjugation (1)
- picture comprehension (1)
- pig microbiome (1)
- pigment epithelium derived factor (1)
- pigment pattern (1)
- pigment-dispersing factor (1)
- pigs (1)
- pilot-point-approach (1)
- placental mammals (1)
- plant-insect-microbe interactions (1)
- plasma cells (1)
- plasma modelling (1)
- plasmablasts (1)
- plasmonics (1)
- platelet (1)
- platelet biogenesis (1)
- polarity (1)
- polarization (1)
- policy (1)
- politics (1)
- polity (1)
- pollen (1)
- pollination (1)
- pollinator interactions (1)
- polyatomic molecules (1)
- polymer processing (1)
- polymorphonuclear neutrophils (1)
- population density (1)
- porin (1)
- pose estimation (1)
- potassium (1)
- potter sequence (1)
- power training (1)
- precipitates (1)
- preclinical research (1)
- predictive markers (1)
- predictor analysis (1)
- prejudice (1)
- premutation (1)
- presence (1)
- pressure sensor (1)
- preterm (1)
- prevalence (1)
- prevention (1)
- prezygotic reproductive isolation (1)
- primary polydipsia (1)
- prime number (1)
- probability of scoring a goal (1)
- probiotic (1)
- probiotica (1)
- procedural fusion methods (1)
- processing speed (1)
- profile of democracy (1)
- progenitors (1)
- prognosis (1)
- program (1)
- proliferation (1)
- propionic acid (1)
- prospective (1)
- prospective study (1)
- prostate-specific membrane antigen (1)
- prostate-specific membrane antigen (PSMA) (1)
- protease-sensitive release (1)
- protein and mRNA expression (1)
- protein hydrolysis (1)
- protein maturation (1)
- protein modification (1)
- protein therapeutics (1)
- proteolipid protein (1)
- proton-proton collision (1)
- proton-proton collisions (1)
- psychiatric disorders (1)
- psychologists (1)
- psychometrics (1)
- public health medicine (1)
- pulse simulation (1)
- pyrrolidine carboxamides (1)
- quality assurance (1)
- quality evaluation (1)
- quality indicators (1)
- quality of democracy (1)
- quantification (1)
- quantitative analysis (1)
- quantitative imaging (1)
- question format (1)
- questionnaire (1)
- rac1 inhibitors (1)
- radiation (1)
- radiation effects (1)
- radiation response (1)
- radionuclide therapy (1)
- radiotherapy (1)
- radium (1)
- random forest (1)
- randomised controlled trial (1)
- ras (1)
- rat hippocampal neurons (1)
- reaction time (1)
- rearrangement (1)
- recategorization (1)
- receptor internalization (1)
- recombinant DNA (1)
- reconstruction (1)
- recurrence (1)
- redox reactions (1)
- regenerative medicine (1)
- regression analysis (1)
- regularization (1)
- regulatory T cells (1)
- relative dosimetry (1)
- remote sensing (1)
- renal failure (1)
- renal tubular dysgenesis (1)
- renin-angiotensin system (1)
- repeated exercise (1)
- repeated sprint running (1)
- reporting and data system (1)
- reporting and data systems (1)
- rescue mission (1)
- research software (1)
- resistive micromegas (1)
- resource mapping (1)
- resource suitability (1)
- respiratory distress (1)
- retinal development (1)
- retinal pigment epithelium (1)
- retrieval practice (1)
- reverse transcriptase inhibitors (1)
- revision (1)
- reward (1)
- ribozymes (1)
- rice–plant infection (1)
- ring-barking (1)
- risk assessment (1)
- robotic (1)
- rodent model (1)
- rotator cuff (1)
- rule discovery (1)
- ruthenium complexes (1)
- salivary alpha-amylase (1)
- salivary gland (1)
- sampling method (1)
- sarcoidosis (1)
- scaffold (1)
- scanning probe microscopy (1)
- scapula (1)
- scatter radiation (1)
- scientists (1)
- seahorse (1)
- search (1)
- second-tier cities (1)
- secretion (1)
- sedentary lifestyle (1)
- segmentation (1)
- selective retina therapy (1)
- selectivity (1)
- self-concept (1)
- self-reactivity (1)
- semantic fusion (1)
- semantic web (1)
- semiconductor devices (1)
- senescence (1)
- sensitivity analysis (1)
- sensorineural hearing loss (1)
- sensory cues (1)
- sensory neuropathy (1)
- sepsis (1)
- sex chromosomes (1)
- sex differentiation (1)
- sexual conflict (1)
- sexually antagonistic genes (1)
- signal integration (1)
- signal processing (1)
- signal transduction (1)
- significance testing (1)
- signs and symptoms (1)
- silk fibroin scaffolds (1)
- simulation (1)
- single photon emission computed tomography: sympathetic nerve (1)
- single top quark (1)
- single-wall carbon nanotubes (1)
- six-minute walk test (1)
- skeletal dysplasia (1)
- skeletal muscle (1)
- skin biopsy (1)
- skin conduction response (1)
- small-molecule activation (1)
- smart soccer boot (1)
- smartwatch (1)
- snags (1)
- social bees (1)
- social capital (1)
- social comparison (1)
- social identification (1)
- social interaction (1)
- soil and water conservation (1)
- soil erosion (1)
- somatostatin receptor (SSTR) (1)
- somatostatin receptors (1)
- spacer (1)
- speciation (1)
- species interactions (1)
- species richness (1)
- spectral sensitivity (1)
- specular reflective (1)
- spiders (1)
- spin-orbitronics (1)
- spinal cord injury (1)
- spine trauma (1)
- spintronic (1)
- splicing (1)
- standardization (1)
- standing deadwood (1)
- staphylinid beetles (1)
- state-based model (1)
- statins (1)
- statistical significance (1)
- steady-state dendritic cells (1)
- stem cells (1)
- stereotactic body radiotherapy (1)
- storage vesicle turnover (1)
- store-operated calcium entry (1)
- streptozotocin (1)
- structure elucidation (1)
- structure-activity relationship (1)
- students (1)
- study system (1)
- stx-Phagen (1)
- subarachnoid hemorrhage (1)
- subphenotypes (1)
- substandard and falsified medicines (1)
- substantia nigra (1)
- supervisors (1)
- support vector machines (1)
- supramolecular chemistry (1)
- surface reflectances (1)
- surgical trauma room (1)
- surveillance (1)
- survey (1)
- sustainability (1)
- sustainable irrigation system (1)
- swarming (1)
- sweat osmolality (1)
- sweat secretion rate (1)
- sweet spot (1)
- symmetries (1)
- sympathetic nervous system (1)
- synapse (1)
- synaptic development (1)
- synaptic proteins (1)
- synaptic vesicles (1)
- sync-oligometastases (1)
- synthetic methodology (1)
- systemic micro-inflammation oxidative stress (1)
- tDCS (1)
- tVNS (1)
- tanzania (1)
- task complexity (1)
- taste (1)
- teleost fish (1)
- telephone-assisted self-help (1)
- temperate zones (1)
- temporal organization (1)
- tenting (1)
- teriflunomide (1)
- terror attack (1)
- testing effect (1)
- testis (1)
- text comprehension (1)
- the microtubule-organizing center (1)
- theme park (1)
- theoretical calculations (1)
- theory and computation (1)
- therapeutic approach (1)
- therapeutic vaccines (1)
- thermal camera (1)
- thermal stresses (1)
- thermoregulation (1)
- three-dimensional echocardiography (1)
- three-toed woodpecker (Picoides tridactylus) (1)
- thyroid stimulating hormone receptor (1)
- tight junction protein (1)
- tight junctions (1)
- tikhonov regularization (1)
- timing (1)
- tissue culture (1)
- tolerogenic dendritic cells (1)
- topological insulator (1)
- topological insulators (1)
- topological matter (1)
- topological superconductor (1)
- total hip arthroplasty (1)
- toxicology (1)
- track and trace (1)
- trade-off (1)
- trafficking pathways (1)
- trail making test (1)
- training curriculum (1)
- training intensity (1)
- trans-Golgi network (1)
- transcriptional profiling (1)
- transcriptional regulation (1)
- transcriptional rewiring (1)
- transcriptional termination (1)
- transcriptomics (1)
- transgluteal approach (1)
- transient absorption spectroscopy (1)
- transition metal complex (1)
- translocation (1)
- transparent (1)
- transplantation (1)
- transport coefficients (1)
- transportation (1)
- treated metastases control (1)
- tree cavity (1)
- triple-negative breast cancer (1)
- trypanobot (1)
- trypanosoma (1)
- tsetse (1)
- tumor (1)
- tumor infiltrating lymphocytes (1)
- two-color microscopy (1)
- two-component system (1)
- two-dimensional electron gas (1)
- two-dimensional materials (1)
- type 2 (1)
- type II esophageal achalasia (1)
- tyrosine recombinase (1)
- uPA (1)
- ubiquitin (1)
- ulnar-shortening osteotomy (1)
- ultrafast photochemistry (1)
- ultrasound strain elastography (1)
- unilateral ureteral obstruction (1)
- university teaching (1)
- valence (1)
- valsartan (1)
- value of water (1)
- vancomycin (1)
- variational fracture (1)
- varroa (1)
- vascular endothelial growth factor (1)
- vaskuläre glatte Muskelzelle (1)
- vasopressin (1)
- vector-like quarks (1)
- vemurafenib (1)
- vena contracta area (1)
- ventromedial prefrontal cortex (1)
- venus (1)
- vertigo (1)
- very high energy (1)
- virus-infection (1)
- viruses (1)
- visual complexity (1)
- visual pigments (1)
- visuomotor coordination (1)
- vitamin metabolism (1)
- volumetric MRI (1)
- volvox carteri (1)
- vorticity preserving (1)
- waggle dance (1)
- water fat separation (1)
- water microbiology (1)
- water oxidation (1)
- wearable (1)
- wearable technology (1)
- web-based apps (1)
- weighted gene co-expression network (1)
- well posedness (1)
- whole exome sequencing (1)
- whole-blood infection assay (1)
- whole-blood model (1)
- whole-cell currents (1)
- wild bees (1)
- wild honey bees (1)
- work behavior (1)
- work capacity evaluation (1)
- working memory (1)
- workplace (1)
- world health organization (1)
- xenobiotic metabolism (1)
- ylides (1)
- zebrafish (1)
- zeitgeber (1)
- zeitliche Organisation (1)
- Ökonometrisches Modell (1)
- Übergangsmetall (1)
- Übergangsmetallkomplexe (1)
- α-emitter (1)
- β-Hydroxybutyrate (1)
- β-cells (1)
- β3 adrenergic receptor (ADRB3) (1)
- β8-β9 loop (1)
- γ-H2AX (1)
Institute
- Physikalisches Institut (84)
- Theodor-Boveri-Institut für Biowissenschaften (84)
- Graduate School of Life Sciences (64)
- Klinik und Poliklinik für Nuklearmedizin (34)
- Institut für Anorganische Chemie (22)
- Institut für Psychologie (22)
- Klinik und Poliklinik für Psychiatrie, Psychosomatik und Psychotherapie (20)
- Medizinische Klinik und Poliklinik II (18)
- Institut für Informatik (15)
- Institut für Virologie und Immunbiologie (15)
Sonstige beteiligte Institutionen
- Johns Hopkins School of Medicine (15)
- Johns Hopkins University School of Medicine (5)
- Department of Biomedical Imaging, National Cerebral and Cardiovascular Research Center, Suita, Japan (2)
- Division of Medical Technology and Science, Department of Medical Physics and Engineering, Course of Health Science, Osaka University Graduate School of Medicine, Suita Japan (2)
- Institut for Molecular Biology and CMBI, Department of Genomics, Stem Cell Biology and Regenerative Medicine, Leopold-Franzens-University Innsbruck, Innsbruck, Austria (2)
- International Max Planck Research School Molecular Biology, University of Göttingen, Germany (2)
- Johns Hopkins School of Medicine, The Russell H Morgan Department of Radiology and Radiological Science, Baltimore, MD, USA (2)
- ACC GmbH Analytical Clinical Concepts (1)
- BMBF (1)
- Boehringer Ingelheim Pharma GmbH & Co. KG (1)
ResearcherID
- J-8841-2015 (1)
Heterozygous mutations in the glucocerebrosidase gene (GBA1) represent the most common genetic risk factor for Parkinson's disease (PD) and are histopathologically associated with a widespread load of alpha-synuclein in the brain. Therefore, PD patients with GBA1 mutations are a cohort of high interest for clinical trials on disease-modifying therapies targeting alpha-synuclein. There is evidence that detection of phospho-alpha-synuclein (p-syn) in dermal nerve fibers might be a biomarker for the histopathological identification of PD patients even at premotor or very early stages of disease. It is so far unknown whether dermal p-syn deposition can also be found in PD patients with GBA1 mutations and may serve as a biomarker for PD in these patients. Skin biopsies of 10 PD patients with different GBA1 mutations (six N3705, three E326K, one L444P) were analyzed by double-immunofluorescence labeling with anti-p-syn and anti-protein gene product 9.5 (PGP9.5, axonal marker) to detect intraaxonal p-syn deposition. Four biopsy sites (distal, proximal leg, paravertebral Th10, and C7) per patient were studied. P-syn was found in six patients (three N370S, three E326K). P-syn deposition was mainly detected in autonomic nerve fibers, but also in somatosensory fibers and was not restricted to a certain GBA1 mutation. In summary, dermal p-syn in PD patients with GBA1 mutations seems to offer a similar distribution and frequency as observed in patients without a known mutation. Skin biopsy may be suitable to study p-syn deposition in these patients or even to identify premotor patients with GBA1 mutations.
In the recent two decades, LIM and SH3 protein 1 (LASP1) has been developed from a simple actin-binding structural protein to a tumor biomarker and subsequently to a complex, nuclear transcriptional regulator. Starting with a brief historical perspective, this review will mainly compare and contrast LASP1 and LASP2 from the angle of the newest data and importantly, examine their role in transcriptional regulation. We will summarize the current knowledge through pictorial models and tables including the roles of different microRNAs in the differential regulation of LASP1 levels and patient outcome rather than specify in detail all tumor entities. Finally, the novel functional roles of LASP1 in secretion of vesicles, expression of matrix metalloproteinases and transcriptional regulation as well as the activation of survival and proliferation pathways in different cancer types are described.
The probiotic escherichia coli strain Nissle 1917 combats lambdoid bacteriophages stx and lambda
(2018)
Shiga toxin (Stx) producing E. coli (STEC) such as Enterohemorrhagic E. coli (EHEC) are the major cause of foodborne illness in humans. In vitro studies showed the probiotic Escherichia coil strain Nissle 1917 (EcN) to efficiently inhibit the production of Stx. Life threatening EHEC strains as for example the serotype 0104:H4, responsible for the great outbreak in 2011 in Germany, evolutionary developed from certain E. coll strains which got infected by stx2-encoding lambdoid phages turning the E. coil into lysogenic and subsequently Stx producing strains. Since antibiotics induce stx genes and Stx production, EHEC infected persons are not recommended to be treated with antibiotics. Therefore, EcN might be an alternative medication. However, because even commensal E. coli strains might be converted into Stx-producers after becoming host to a stx encoding prophage, we tested EcN for stx-phage genome integration. Our experiments revealed the resistance of EcN toward not only stx-phages but also against lambda-phages. This resistance was not based on the lack of or by mutated phage receptors. Rather it involved the expression of a phage repressor (pr) gene of a defective prophage in EcN which was able to partially protect E. coli K-12 strain MG1655 against stx and lambda phage infection. Furthermore, we observed EcN to inactivate phages and thereby to protect E. coli K-12 strains against infection by stx- as well as lambda-phages. Inactivation of lambda-phages was due to binding of lambda-phages to LamB of EcN whereas inactivation of stx-phages was caused by a thermostable protein of EcN. These properties together with its ability to inhibit Stx production make EcN a good candidate for the prevention of illness caused by EHEC and probably for the treatment of already infected people.
Glycine receptors (GlyRs) are important mediators of fast inhibitory neurotransmission in the mammalian central nervous system. Their function is controlled by multiple cellular mechanisms, including intracellular regulatory processes. Modulation of GlyR function by protein kinases has been reported for many cell types, involving different techniques, and often yielding contradictory results. Here, we studied the effects of protein kinase C (PKC) and cAMP-dependent protein kinase A (PKA) on glycine induced currents in HEK293 cells expressing human homomeric \(\alpha\)1 and heteromeric \(\alpha\)1-\(\beta\) GlyRs using whole-cell patch clamp techniques as well as internalization assays. In whole-cell patch-clamp measurements, modulators were applied in the intracellular buffer at concentrations between 0.1 \(\mu\)M and 0.5 \(\mu\)M. EC50 of glycine increased upon application of the protein kinase activators Forskolin and phorbol-12-myristate-13-acetate (PMA) but decreased in the presence of the PKC inhibitor Staurosporine aglycon and the PKA inhibitor H-89. Desensitization of recombinant \(\alpha\)1 receptors was significantly increased in the presence of Forskolin. Staurosporine aglycon, on the other hand decreased desensitization of heteromeric \(\alpha\)1-\(\beta\) GlyRs. The time course of receptor activation was determined for homomeric \(\alpha\)1 receptors and revealed two simultaneous effects: cells showed a decrease of EC50 after 3-6 min of establishing whole-cell configuration. This effect was independent of protein kinase modulators. All modulators of PKA and PKC, however, produced an additional shift of EC50, which overlay and eventually exceeded the cells intrinsic variation of EC50. The effect of kinase activators was abolished if the corresponding inhibitors were co-applied, consistent with PKA and PKC directly mediating the modulation of GlyR function. Direct effects of PKA-and PKC-modulators on receptor expression on transfected HEK cells were monitored within 15 min of drug application, showing a significant increase of receptor internalization with PKA and PKC activators, while the corresponding inhibitors had no significant effect on receptor surface expression or internalization. Our results confirm the observation that phosphorylation via PKA and PKC has a direct effect on the GlyR ion channel complex and plays an important role in the fine-tuning of glycinergic signaling.
Voluntary movements induce postural perturbations which are counteracted by anticipatory postural adjustments (APAs). These actions are known to build up long fixation chains toward available support points (inter-limb APAs), so as to grant whole body equilibrium. Moreover, recent studies highlighted that APAs also build-up short fixation chains, within the same limb where a distal segment is moved (intra-limb APAs), aimed at stabilizing the proximal segments. The neural structures generating intra-limb APAs still need investigations; the present study aims to compare focal movement kinematics and intra-limb APA latencies and pattern between healthy subjects and parkinsonian patients, assuming the latter as a model of basal ganglia dysfunction. Intra-limb APAs that stabilize the arm when the index-finger is briskly flexed were recorded in 13 parkinsonian patients and in 10 age-matched healthy subjects. Index-finger movement was smaller in parkinsonian patients vs. healthy subjects (p = 0.01) and more delayed with respect to the onset of the prime mover flexor digitorum superficialis (FDS, p < 0.0001). In agreement with the literature, in all healthy subjects the FDS activation was preceded by an inhibitory intra-limb APA in biceps brachii (BB) and anterior deltoid (AD), and almost simultaneous to an excitatory intra-limb APA in triceps brachii (TB). In parkinsonian patients, no significant differences were found for TB and AD intra-limb APA timings, however only four patients showed an inhibitory intra-limb APA in BB, while other four did not show any BB intra-limb APAs and five actually developed a BB excitation. The frequency of occurrence of normal sign, lacking, and inverted BB APAs was different in healthy vs. parkinsonian participants (p = 0.0016). The observed alterations in index-finger kinematics and intra-limb APA pattern in parkinsonian patients suggest that basal ganglia, in addition to shaping the focal movement, may also contribute to intra-limb APA control.
The immune suppressants cyclosporin A (CsA) and tacrolimus (FK506) are used worldwide in transplantation medicine to suppress graft rejection. Both CsA and FK506 inhibit the phosphatase calcineurin (CN) whose activity controls the immune receptor-mediated activation of lymphocytes. Downstream targets of CN in lymphocytes are the nuclear factors of activated T cells (NFATs). We show here that the activity of NFATc1, the most prominent NFAT factor in activated lymphocytes supports the acute rejection of heterotopic heart allografts. While ablation of NFATc1 in T cells prevented graft rejection, ectopic expression of inducible NFATc1/αA isoform led to rejection of heart allografts in recipient mice. Acceptance of transplanted hearts in mice bearing NFATc1-deficient T cells was accompanied by a reduction in number and cytotoxicity of graft infiltrating cells. In CD8\(^+\) T cells, NFATc1 controls numerous intracellular signaling pathways that lead to the metabolic switch to aerobic glycolysis and the expression of numerous lymphokines, chemokines, and their receptors, including Cxcr3 that supports the rejection of allogeneic heart transplants. These findings favors NFATc1 as a molecular target for the development of new strategies to control the cytotoxicity of T cells upon organ transplantation.
Staphylococcus epidermidis, the common inhabitant of human skin and mucosal surfaces has emerged as an important pathogen in patients carrying surgical implants and medical devices. Entering the body via surgical sites and colonizing the medical devices through formation of multi-layered biofilms leads to refractory and persistent device-related infections (DRIs). Staphylococci organized in biofilms are more tolerant to antibiotics and immune responses, and thus are difficult-to-treat. The consequent morbidity and mortality, and economic losses in health care systems has strongly necessitated the need for development of new anti-bacterial and anti-biofilm-based therapeutics. In this study, we describe the biological activity of a marine sponge-derived Streptomyces sp. SBT348 extract in restraining staphylococcal growth and biofilm formation on polystyrene, glass, medically relevant titan metal, and silicone surfaces. A bioassay-guided fractionation was performed to isolate the active compound (SKC3) from the crude SBT348 extract. Our results demonstrated that SKC3 effectively inhibits the growth (MIC: 31.25 \(\mu\)g/ml) and biofilm formation (sub-MIC range: 1.95-<31.25 \(\mu\)g/ml) of S. epidermidis RP62A in vitro. Chemical characterization of SKC3 by heat and enzyme treatments, and mass spectrometry (HRMS) revealed its heat-stable and non-proteinaceous nature, and high molecular weight (1258.3 Da). Cytotoxicity profiling of SKC3 in vitro on mouse fibroblast (NIH/3T3) and macrophage (J774.1) cell lines, and in vivo on the greater wax moth larvae Galleria mellonella revealed its non-toxic nature at the effective dose. Transcriptome analysis of SKC3 treated S. epidermidis RP62A has further unmasked its negative effect on central metabolism such as carbon flux as well as, amino acid, lipid, and energy metabolism. Taken together, these findings suggest a potential of SKC3 as a putative drug to prevent staphylococcal DRIs.
Background
Peritoneal carcinomatosis (PC) represents an unfavourable prognostic factor for patients with gastric cancer (GC). Intraperitoneal treatment with the bispecific and trifunctional antibody catumaxomab (EpCAM, CD3), in addition to systemic chemotherapy, could improve elimination of PC.
Methods
This prospective, randomised, phase II study investigated the efficacy of catumaxomab followed by chemotherapy (arm A, 5-fluorouracil, leucovorin, oxaliplatin, docetaxel, FLOT) or FLOT alone (arm B) in patients with GC and PC. Primary endpoint was the rate of macroscopic complete remission (mCR) of PC at the time of second diagnostic laparoscopy/laparotomy prior to optional surgery.
Results
Median follow-up was 52 months. Out of 35 patients screened, 15 were allocated to arm A and 16 to arm B. mCR rate was 27% in arm A and 19% in arm B (p = 0.69). Severe side effects associated with catumaxomab were nausea, infection, abdominal pain, and elevated liver enzymes. Median progression-free (6.7 vs. 5.4 months, p = 0.71) and overall survival (13.2 vs. 13.0 months, p = 0.97) were not significantly different in both treatment arms.
Conclusions
Addition of catumaxomab to systemic chemotherapy was feasible and tolerable in advanced GC. Although the primary endpoint could not be demonstrated, results are promising for future investigations integrating intraperitoneal immunotherapy into a multimodal treatment strategy.
Tumor treating fields (TTFields) are approved for glioblastoma (GBM) therapy. TTFields disrupt cell division by inhibiting spindle fiber formation. Spindle assembly checkpoint (SAC) inhibition combined with antimitotic drugs synergistically decreases glioma cell growth in cell culture and mice. We hypothesized that SAC inhibition will increase TTFields efficacy. Human GBM cells (U-87 MG, GaMG) were treated with TTFields (200 kHz, 1.7 V/cm) and/or the SAC inhibitor MPS1-IN-3 (IN-3, 4 µM). Cells were counted after 24, 48, and 72 h of treatment and at 24 and 72 h after end of treatment (EOT). Flow cytometry, immunofluorescence microscopy, Annexin-V staining and TUNEL assay were used to detect alterations in cell cycle and apoptosis after 72 h of treatment. The TTFields/IN-3 combination decreased cell proliferation after 72 h compared to either treatment alone (−78.6% vs. TTFields, P = 0.0337; −52.6% vs. IN-3, P = 0.0205), and reduced the number of viable cells (62% less than seeded). There was a significant cell cycle shift from G1 to G2/M phase (P < 0.0001). The apoptotic rate increased to 44% (TTFields 14%, P = 0.0002; IN-3 4%, P < 0.0001). Cell growth recovered 24 h after EOT with TTFields and IN-3 alone, but the combination led to further decrease by 92% at 72 h EOT if IN-3 treatment was continued (P = 0.0288). The combination of TTFields and SAC inhibition led to earlier and prolonged effects that significantly augmented the efficacy of TTFields and highlights a potential new targeted multimodal treatment for GBM.
Histone H3 serine 28 (H3S28) phosphorylation and de-repression of polycomb repressive complex (PRC)-mediated gene regulation is linked to stress conditions in mitotic and post-mitotic cells. To better understand the role of H3S28 phosphorylation in vivo, we studied a Drosophila strain with ectopic expression of constitutively-activated H3S28A, which prevents PRC2 binding at H3S28, thus mimicking H3S28 phosphorylation. H3S28A mutants showed prolonged life span and improved resistance against starvation and paraquat-induced oxidative stress. Morphological and functional analysis of heart tubes revealed smaller luminal areas and thicker walls accompanied by moderately improved cardiac function after acute stress induction. Whole-exome deep gene-sequencing from isolated heart tubes revealed phenotype-corresponding changes in longevity-promoting and myotropic genes. We also found changes in genes controlling mitochondrial biogenesis and respiration. Analysis of mitochondrial respiration from whole flies revealed improved efficacy of ATP production with reduced electron transport-chain activity. Finally, we analyzed posttranslational modification of H3S28 in an experimental heart failure model and observed increased H3S28 phosphorylation levels in HF hearts. Our data establish a critical role of H3S28 phosphorylation in vivo for life span, stress resistance, cardiac and mitochondrial function in Drosophila. These findings may pave the way for H3S28 phosphorylation as a putative target to treat stress-related disorders such as heart failure.