Refine
Has Fulltext
- yes (12)
Is part of the Bibliography
- yes (12)
Year of publication
- 2017 (12) (remove)
Document Type
- Journal article (7)
- Conference Proceeding (5)
Keywords
- PET (7)
- CXCR4 (4)
- theranostics (4)
- Positronen-Emissions-Tomografie (3)
- medicine (3)
- multiple myeloma (3)
- FDG (2)
- PET/CT (2)
- PRRT (2)
- positron emission tomography (2)
- 177Lu-DOTATATE (1)
- 177Lu-DOTATOC (1)
- 18F-DCFPL (1)
- 18F-FDG (1)
- 18F-LMI1195 (1)
- DOTATOC (1)
- Diabetes (1)
- ECG (1)
- ECG-gated (1)
- EKG (1)
- Ganglia (1)
- Herz (1)
- Imaging pitfalls (1)
- MIBG (1)
- Metaiodobenzylguanidine (1)
- Neuroendocrine Tumor (1)
- PSMA (1)
- Pitfall (1)
- Prostata (1)
- Prostate Cancer (1)
- Radiotracer (1)
- SSTR (1)
- TKI (1)
- Tracer (1)
- [\(^{68}\)Ga] pentixafor (1)
- [\(^{68}\)Ga]Pentixafor (1)
- \(^{11}\)C-methionine (1)
- antidepressants (1)
- autonomic nervous system (1)
- cardiac (1)
- chemokine receptor (1)
- diabetische Kardiomyopathie (1)
- endocrinology (1)
- heart (1)
- mIBG (1)
- molecular imaging (1)
- molecular medicine (1)
- neuroendocrine tumor (1)
- peptide receptor radionuclide therapy (1)
- pleural mesothelioma (1)
- radionuclide therapy (1)
- sympathetic nerve (1)
- vandetanib (1)
Institute
- Klinik und Poliklinik für Nuklearmedizin (12) (remove)
Sonstige beteiligte Institutionen
EU-Project number / Contract (GA) number
- 701983 (7)
\(^{11}\)C-methionine-PET in multiple myeloma: a combined study from two different institutions
(2017)
\(^{11}\)C-methionine (MET) has recently emerged as an accurate marker of tumor burden and disease activity in patients with multiple myeloma (MM). This dual-center study aimed at further corroboration of the superiority of MET as positron emission tomography (PET) tracer for staging and re-staging MM, as compared to \(^{18}\)F-2`-deoxy-2`-fluoro-D-glucose (FDG).
78 patients with a history of solitary plasmacytoma (n=4), smoldering MM (SMM, n=5), and symptomatic MM (n=69) underwent both MET- and FDG-PET/computed tomography (CT) at the University Centers of Würzburg, Germany and Navarra, Spain. Scans were compared on a patient and on a lesion basis. Inter-reader agreement was also evaluated. In 2 patients, tumor biopsies for verification of discordant imaging results were available.
MET-PET detected focal lesions (FL) in 59/78 subjects (75.6%), whereas FDG-PET/CT showed lesions in only 47 patients (60.3%; p<0.01), accordingly disease activity would have been missed in 12 patients. Directed biopsies of discordant results confirmed MET-PET/CT results in both cases.
MET depicted more FL in 44 patients (56.4%; p<0.01), whereas in two patients (2/78), FDG proved superior. In the remainder (41.0%, 32/78), both tracers yielded comparable results. Inter-reader agreement for MET was higher than for FDG (κ = 0.82 vs κ = 0.72).
This study demonstrates higher sensitivity of MET in comparison to standard FDG to detect intra- and extramedullary MM including histologic evidence of FDG-negative, viable disease exclusively detectable by MET-PET/CT. MET holds the potential to replace FDG as functional imaging standard for staging and re-staging of MM.
Brown adipose tissue (BAT) is an attractive therapeutic target to combat diabetes and obesity due to its ability to increase glucose expenditure. In a genetic rat model (ZDF fa/fa) of type-2 diabetes and obesity, we aimed to investigate glucose utilization of BAT by \(^{18}\)F-FDG PET imaging. Male Zucker diabetic fatty (ZDF) and Male Zucker lean (ZL) control rats were studied at 13 weeks. Three weeks prior to imaging, ZDF rats were randomized into a no-restriction (ZDF-ND) and a mild calorie restriction (ZDF-CR) group. Dynamic \(^{18}\)F-FDG PET using a dedicated small animal PET system was performed under hyperinsulinemic-euglycemic clamp. \(^{18}\)F-FDG PET identified intense inter-scapular BAT glucose uptake in all ZL control rats, while no focally increased \(^{18}\)F-FDG uptake was detected in all ZDF-ND rats. Mild but significant improved BAT tracer uptake was identified after calorie restriction in diabetic rats (ZDF-CR). The weight of BAT tissue and fat deposits were significantly increased in ZDF-CR and ZDF-ND rats as compared to ZL controls, while UCP-1 and mitochondrial concentrations were significantly decreased. Whitening and severely impaired insulin-stimulated glucose uptake in BAT was confirmed in a rat model of type-2 diabetes. Additionally, calorie restriction partially restored the impaired BAT glucose uptake.