Refine
Has Fulltext
- yes (333)
Is part of the Bibliography
- yes (333)
Year of publication
Document Type
- Journal article (333) (remove)
Keywords
- chronic kidney disease (17)
- heart failure (15)
- Fabry disease (13)
- adrenocortical carcinoma (13)
- mortality (12)
- inflammation (11)
- echocardiography (10)
- myocardial infarction (10)
- hemodialysis (9)
- prognosis (8)
- biomarker (7)
- cardiomyopathy (7)
- cortisol (7)
- depression (6)
- heart (6)
- obesity (6)
- therapy (6)
- CXCR4 (5)
- PET (5)
- anxiety (5)
- atherosclerosis (5)
- biomarkers (5)
- blood pressure (5)
- cardiovascular disease (5)
- cardiovascular diseases (5)
- enzyme replacement therapy (5)
- metabolomics (5)
- mouse (5)
- paraganglioma (5)
- pheochromocytoma (5)
- prevalence (5)
- type 2 diabetes (5)
- Cushing’s syndrome (4)
- cardiovascular events (4)
- coronary heart disease (4)
- cytokines (4)
- diabetes mellitus (4)
- diagnosis (4)
- epidemiology (4)
- fibrosis (4)
- hypercortisolism (4)
- hypertension (4)
- ischemic stroke (4)
- miRNA (4)
- mice (4)
- oxidative stress (4)
- radial (4)
- risk factors (4)
- survival (4)
- theranostics (4)
- ACTH (3)
- CMR (3)
- COVID-19 (3)
- FGFR (3)
- Heart failure (3)
- MRI (3)
- SOAT1 (3)
- adrenocortical cancer (3)
- amyloidosis (3)
- blood (3)
- cancer (3)
- cardiac hypertrophy (3)
- cardiac magnetic resonance imaging (3)
- cognitive decline (3)
- cognitive impairment (3)
- coronary artery disease (3)
- desmin (3)
- diabetes (3)
- dialysis (3)
- diet (3)
- end-stage renal disease (3)
- endoradiotherapy (3)
- follow-up (3)
- genetics (3)
- guidelines (3)
- hypertrophic cardiomyopathy (3)
- immune response (3)
- immunohistochemistry (3)
- impact (3)
- kidney (3)
- left ventricular hypertrophy (3)
- liraglutide (3)
- lymphocytes (3)
- machine learning (3)
- management (3)
- medicine (3)
- melanoma (3)
- mitotane (3)
- multicenter (3)
- osteoporosis (3)
- outcomes (3)
- quality of life (3)
- safety (3)
- treatment (3)
- vitamin D (3)
- 18F-FDG (2)
- 4D flow (2)
- C-X-C motif chemokine receptor 4 (2)
- CYP2W1 (2)
- Chronic kidney disease (2)
- Cushing’s disease (2)
- Depression (2)
- Diabetes mellitus (2)
- Enzyme replacement therapy (2)
- FGF-pathway (2)
- Fabry genotype (2)
- Fabry nephropathy (2)
- Fabry phenotype (2)
- GFAP (2)
- Germany (2)
- KDIGO (2)
- Kidney function (2)
- Medicine (2)
- Medizin (2)
- Mortality (2)
- NAFLD (2)
- Neurons (2)
- PPGL (2)
- Positronen-Emissions-Tomografie (2)
- Prevalence (2)
- Quality of life (2)
- Roux-en-Y gastric bypass surgery (2)
- SF-36 (2)
- TAVI (2)
- United States (2)
- WSS (2)
- [68Ga]PentixaFor (2)
- ablation (2)
- acute heart failure (2)
- acute kidney injury (2)
- adenomas (2)
- adrenal (2)
- adrenal cancer (2)
- adrenal crisis (2)
- adrenal insufficiency (2)
- adrenal tumours (2)
- adrenocortical tumors (2)
- age (2)
- aging (2)
- aldosterone (2)
- aneurysm (2)
- antimicrobial resistance (2)
- aortic arch (2)
- arrhythmia (2)
- association (2)
- blood flow (2)
- body mass index (2)
- body weight (2)
- bone (2)
- calcification (2)
- cancer treatment (2)
- carbohydrates (2)
- carcinomas (2)
- cardiac (2)
- cardiac MRI (2)
- cardiac surgery (2)
- cardiology (2)
- cardiovascular genetics (2)
- cardiovascular magnetic resonance (2)
- cardiovascular morbidity (2)
- cardiovascular risk factors (2)
- catecholamines (2)
- chemokine receptor (2)
- chronic cerebrovascular disease (2)
- chronic heart failure (2)
- chronic kidney-disease (2)
- convection volume (2)
- copeptin (2)
- deep learning (2)
- deformation (2)
- dementia (2)
- desmosomes (2)
- dialysis adequacy (2)
- efficacy (2)
- ejection fraction (2)
- gastric bypass (2)
- genome-wide association (2)
- glomerular filtration rate (2)
- glycemic control (2)
- guideline adherence (2)
- hemodiafiltration (2)
- hydrocortisone (2)
- hyperexpression techniques (2)
- identification (2)
- immune cells (2)
- immunotherapy (2)
- insulin resistance (2)
- internal medicine (2)
- kidneys (2)
- left ventricular ejection fraction (2)
- left ventricular mass (2)
- lysosomal storage disease (2)
- magnetic resonance imaging (2)
- mapping (2)
- medullary thyroid carcinoma (2)
- metaanalysis (2)
- mineral metabolism (2)
- morbidity (2)
- mouse models (2)
- multiple myeloma (2)
- myocardial work (2)
- natriuretic peptide (2)
- neuroendocrine tumor (2)
- neurofilament light chain (2)
- pediatric adrenocortical cancer (2)
- pediatric adrenocortical tumor (2)
- pembrolizumab (2)
- peptide tyrosine tyrosine (PYY) (2)
- placebo-controlled trial (2)
- population (2)
- positron emission tomography (2)
- postmenopausal women (2)
- precision medicine (2)
- primary prevention (2)
- prognostic factors (2)
- prognostic marker (2)
- proteinuria (2)
- pulse wave velocity (2)
- quantification (2)
- radiotherapy (RT) (2)
- randomized controlled trial (2)
- receptor (2)
- recurrence (2)
- regulatory T cells (2)
- renal function (2)
- replacement (2)
- restrictive cardiomyopathy (2)
- sepsis (2)
- sizing (2)
- small interfering RNAs (2)
- stage renal-disease (2)
- stem cell transplantation (2)
- stroke (2)
- sudden cardiac death (2)
- surgery (2)
- therapeutic drug monitoring (2)
- troponin (2)
- tyrosine kinase inhibitor (2)
- uremic toxins (2)
- urine (2)
- validation (2)
- vandetanib (2)
- wall shear stress (2)
- 2- deoxy-2-(18F)fluoro-D-glucose (1)
- 2-deoxy-2-(18F)fluoro-D-glucose (1)
- 2-dimensional speckle tracking (1)
- 3 T (1)
- 4D flow MRI (1)
- 7 T (1)
- 7T (1)
- <sup>18</sup>F-FDG (1)
- <sup>68</sup>Ga-Pentixafor (1)
- A-delta fibers (1)
- ACC (1)
- ACC/AHA classification (1)
- ACM (1)
- AKI (1)
- ALT (1)
- ARDS (acute respiratory distress syndrome) (1)
- ARVC (1)
- ASE formula (1)
- ATP generation (1)
- ATRX (1)
- Addison's disease (1)
- Addisons disease (1)
- Adrenocortial carcinomas (1)
- African-americans (1)
- Agalsidase beta (1)
- Akutes Nierenversagen (1)
- Alpha-Galactosidase (1)
- Alpha-galactosidase (1)
- Alzheimer’s dementia (1)
- Amino acids (1)
- Anderson-Fabry Disease (1)
- Angst (1)
- Antigen 4 (1)
- Aorta (1)
- Aortic arch (1)
- Aplastic anemia (1)
- Apoptosis (1)
- Artificial Nuclear Pores (1)
- Atherosclerosis (1)
- Autoimmune-Diseases (1)
- B (1)
- B cells (1)
- BET Inhibitor (1)
- BIRC7 (1)
- BRAF mutation (1)
- BRAF(V600E) mutation (1)
- BRD4 (1)
- Biochemical-Diagnosis (1)
- Bioluminescence (1)
- Brain atrophy (1)
- Brownian ratchet (1)
- C-terminal HSP90 inhibitors (1)
- CASP (1)
- CCR7 (1)
- CD4+ T-cells (1)
- CD9 (1)
- CIED malfunction; pacemaker (PM) (1)
- CKD (1)
- CML (1)
- COH29 (1)
- COMT (1)
- COPD diagnosis (1)
- COVID‐19 vaccination (1)
- CRH stimulation test (1)
- CTNNB1 (1)
- CXCR7 (1)
- CYP2B6 (1)
- Ca cycling (1)
- Ca2+i handling (1)
- Calcineurin-NFATsignaling (1)
- Calcium Citrate (1)
- Calibration (1)
- Cancer genetics (1)
- Cardiac magnetic resonance imaging (1)
- Cardiac resynchronization therapy defibrillator (1)
- CardioMEMS™ HF-System (1)
- Cardiomyopathy (1)
- Cardiovascular diseases (1)
- Cardiovascular hospitalizations (1)
- Cardiovascular risk factors (1)
- Cardiovascular risk prediction (1)
- Carotid intima-media thickness (CIMT) (1)
- Carotid segment (1)
- Carotid ultrasound (1)
- Catheter Lock Solution (1)
- Catheter-related Bloodstream Infections (CRBSI) (1)
- Cell (1)
- Cell lung canger (1)
- Chronic Kidney-disease (1)
- Chronic heart failure (1)
- Chronic heart-failure (1)
- Chronic kidney-disease (1)
- Clinical prediction rule (1)
- Clinical proteomics (1)
- Clinical trial (1)
- Clinical-trials (1)
- Cognitive decline (1)
- Cohort study (1)
- Comorbidities (1)
- Contrast-enhanced CT (1)
- Copeptin (1)
- Coronavirus Disease 2019 (1)
- Cranial sutures (1)
- Cumulative incidence function (1)
- Cushing (1)
- Cushing syndrome (1)
- Cushing's (1)
- Cushing's disease (1)
- Cushings syndrome (1)
- Cytoskeleton (1)
- D313Y genotype (1)
- DIA-MS (1)
- DNA damage (1)
- DOTATOC (1)
- DSC2 (1)
- DSG2 (1)
- Dendritic Cells (1)
- Depression treatment (1)
- Depressive symptomatology (1)
- Desmoplakin (1)
- Diabetic nephropathies (1)
- Diabetic-nephropathy (1)
- Diagnosis (1)
- Diastocic Dysfunction (1)
- Dipeptidyl-peptidase IV inhibitors (1)
- Discovery (1)
- Disease prevalence (1)
- Diversity (1)
- Dokumentationsqualität (1)
- E/e’ (1)
- ECG (1)
- EMT (1)
- EP Procedures (1)
- ESC (1)
- EUROASPIRE (1)
- EUROASPIRE survey (1)
- Embryos (1)
- Enhancer elements (1)
- Epidemiology (1)
- Eplerenone (1)
- European Society (1)
- Expression (1)
- Extracellular volume (1)
- Extracorporeal membrane oxygenation (1)
- F-18-FDG PET/CT (1)
- FGF21 (1)
- FGFR-inhibitors (1)
- Fabry (1)
- Fabry Disease (FD) (1)
- Fabry cardiomyopathy (1)
- Fabry patient (1)
- Fabry-associated pain (1)
- False positive reactions (1)
- Family Investigation of Nephropathy and Diabetes (1)
- Female patients (1)
- Fibroblast Growth Factor-21 (1)
- Fontan’s Operation (1)
- FoxP3 Expression (1)
- Foxp3 (1)
- Framingham (1)
- G protein coupled receptors (1)
- GH response (1)
- GLA protein UCMGP (1)
- GLP-1 (1)
- GMPcGMP-dependent protein kinase I (1)
- GOLD (1)
- GRAPPA (1)
- Galactosidase-A gene (1)
- Gb3 and lyso-Gb3 biomarkers (1)
- General-population (1)
- Genome-wide association studies (1)
- Glial fibrillary acidic protein (1)
- Globotriaosylceramide (1)
- Glomerular-filtration-rate (1)
- Glycaemic control (1)
- Graves disease (1)
- HEK cells (1)
- HFpEF (1)
- HIV (1)
- HIV diagnosis and management (1)
- HLA (1)
- HUVEC (1)
- Haemodialysis (1)
- Hazards (1)
- Healthcare research (1)
- Heart failure with preserved ejection fraction (1)
- Heart failure with reduced ejection fraction (1)
- Hematopoietic cell transplant (1)
- Hemodialysis-patients (1)
- Hemoglobin A1C (1)
- HiGHmed (1)
- Hindbrain (1)
- Home monitoring (1)
- Homoarginine (1)
- Hypercortisolism (1)
- Hyperkalemia (1)
- Hyperosmotic Stress (1)
- ICD-coding of CKD (1)
- IDH1/2 (1)
- IGF-I (1)
- IMAZA (1)
- IP3 (1)
- Immune-System (1)
- Immunological Self-Tolerance (1)
- Immunosuppression (1)
- Impella (1)
- Infection control (1)
- Insulin therapy (1)
- Intensivtransport (1)
- Interhospitaltransfer (1)
- Interleukin-6 (1)
- Internet of Things devices (1)
- JQ1 (1)
- Juvenile biventricular cardiomyopathy (1)
- KWIC (1)
- Kaposi sarcoma (1)
- Klotho-related molecules (1)
- L-arginine (1)
- LCNEC (1)
- LDL cholesterol (1)
- LMNA (1)
- LND (1)
- LNE (1)
- LV dilatation (1)
- LV mass (1)
- LVNC (1)
- Lag time (1)
- Langzeitbeatmung (1)
- Linagliptin (1)
- Long COVID (1)
- Lyso-Gb3 (1)
- MASS (1)
- MEN1 (1)
- MOLLI (1)
- MR (1)
- MR guidance (1)
- MTL30 (1)
- MUST-Score (1)
- Magnetic resonance imaging (1)
- Mass-spectrometry (1)
- Measurement (1)
- Medullärer Schilddrüsenkrebs (1)
- Memory dysfunction (1)
- Men (1)
- Metanephrine (1)
- Methicillin-resistant staphylococcus aureus (1)
- Methodological quality (1)
- Mfn2 KO mice (1)
- Model (1)
- Molecular Channel Transport (1)
- Molekül (1)
- Morbidity (1)
- Morbus Fabry (1)
- Mouse (1)
- Mouse models (1)
- Multiparameter predictor (1)
- Multiple-Sclerosis (1)
- Myeloma (1)
- Myocardial infarction (1)
- Myocardial-Infarction (1)
- N-terminal HSP90 inhibitors (1)
- NASH (1)
- NCI-H295R (1)
- NEC (1)
- NET (1)
- NMR (1)
- NOP10 (1)
- NR3C1 (1)
- NSG animals (1)
- Natural-history data (1)
- Neprilysin inhibition (1)
- Network (1)
- New mexico (1)
- NfL (1)
- Non‐ischaemic cardiogenic shock (1)
- Normetanephrine (1)
- Nrf2 (1)
- OAT1 (1)
- OAT3 (1)
- OK cells (1)
- OSI (1)
- OXPHOS (1)
- Observational study (1)
- Onset hypertrophic cardiomyopathy (1)
- Oral antidiabetic drugs (1)
- Outcome survey (1)
- Outcomes (1)
- P-cresyl sulfate (1)
- PD-L1 (1)
- PF-05231023 (1)
- PHQ-9 (1)
- PRO (1)
- PTA (1)
- PWV (1)
- PYY3-36 (1)
- Pain (1)
- Pain-related evoked potentials (1)
- Palmoplantar keratoderma (1)
- Paraganglioma (1)
- Physical impairment (1)
- Plasma (1)
- Positron-emission-tomography (1)
- Postmarketing Experience (1)
- Predictive value of tests (1)
- Predictors (1)
- Preserved Ejection Fraction (1)
- Primary care (1)
- Probabilities (1)
- Prognostic impact (1)
- Progression (1)
- Protein (1)
- Psychopharmakologie (1)
- Psychotherapie (1)
- RAKI (1)
- RNA Expression (1)
- RNAScope (1)
- RNR (1)
- ROS (1)
- RRM2 (1)
- RYGB (1)
- Racial differences (1)
- Raman micro-spectroscopy (1)
- Recognition of depression (1)
- Regression (1)
- Remote device monitoring (1)
- Research design (1)
- Resistance (1)
- Risk (1)
- Risk-factors (1)
- Rotary EXcitation (REX) (1)
- Roux-en-Y Gastric Bypass (1)
- Roux-en-Y gastric bypass (1)
- SARS‐CoV‐2 infection (1)
- SASHA (1)
- SCORE (1)
- SGLT2 inhibitor (1)
- SGLT2 inhibitors (1)
- SNP (1)
- SR Ca leak (1)
- SR/mitochondria metabolic feedback (1)
- SSTR (1)
- ST-elevation myocardial infarction (1)
- STEMI (1)
- SUMO2 (1)
- Sample-sizes (1)
- Sars-CoV-2 (1)
- Self-navigation (1)
- Septal bulge (1)
- Severe Acute Respiratory Syndrome Coronavirus 2 (1)
- Sex-Hormones (1)
- ShMOLLI (1)
- Skull (1)
- Small fiber neuropathy (1)
- Society (1)
- Somites (1)
- Spin echo (1)
- Stage renal-disease (1)
- Stiffness (1)
- Subdistribution (1)
- Sudden cardiac death (1)
- Suppressive Function (1)
- Survival (1)
- Systemic-Lupus-Erythematosus (1)
- Systole (1)
- T cells (1)
- T-cells (1)
- T1 mapping (1)
- T1rho (1)
- T1ρ (1)
- TERT (1)
- TKI (1)
- TNF-alpha (1)
- TT\(_{1rho}\) mapping (1)
- T\(_{1P}\) dispersion (1)
- T\(_{1P}\) mapping (1)
- Tanzania (1)
- Taurolidine (1)
- Teichholz formula (1)
- Test accuracy (1)
- Tests (1)
- Thermodynamics (1)
- Thermodynamik (1)
- Time measurement (1)
- Transport (1)
- Treatment outcome (1)
- Tregs (regulatory T cells) (1)
- USP28 (1)
- USP8 (1)
- Utility (1)
- VAS (1)
- VEMP (1)
- Valvular heart-desease (1)
- Variants (1)
- Ventricular septal rupture (1)
- Weaning (1)
- X-chromosomal inactivation (1)
- XA (1)
- Young-patients (1)
- ZDF rats (1)
- Zebrafish (1)
- Zucker fatty fa/fa rats (1)
- [11C]-Choline PET/CT (1)
- [11C]-Methionine (1)
- [177Lu]/[90Y]PentixaTher (1)
- [177Lu]PentixaTher (1)
- [18F]FDG-PET-CT (1)
- [90Y]PentixaTher (1)
- [99mTc]-Sestamibi scan (1)
- [\(^{68}\)Ga] pentixafor (1)
- \(^{18}\)F-FDG (1)
- \(^{18}\)F-fluorodeoxyglucose (1)
- abdominal lymph node metastases (1)
- absorption (1)
- accelerated atherosclerosis (1)
- activated-receptor gamma (1)
- activation (1)
- acute respiratory distress syndrome (1)
- adaptive immune response (1)
- add-on (1)
- adenovirus (1)
- adenoviruses (1)
- adenylyl cyclase signaling cascade (1)
- adjuvant platinum-based chemotherapy (1)
- adjuvant therapy (1)
- adjuvant treatment (1)
- adrenal cortex hormones (1)
- adrenal cortex neoplasms (1)
- adrenal gland (1)
- adrenal glands (1)
- adrenal imaging (1)
- adrenal surgery (1)
- adrenal tumor (1)
- adrenal tumors (1)
- adrenalectomia (1)
- adrenocortical (1)
- adrenocortical adenocarcinoma (1)
- adrenocortical adenoma (1)
- adrenocortical carcinoma (ACC) (1)
- adrenocortical cell line (1)
- adrenocortical development (1)
- adrenocortical tissues (1)
- adrenocortical tumor (1)
- adult patients (1)
- adverse effects (1)
- afatinib (1)
- agalsidase-beta (1)
- agnoists (1)
- albumin excretion rate (1)
- albuminuria (1)
- alcohol (1)
- alkaline phosphatase (1)
- allocation (1)
- allogeneic hematopoietic stem cell transplantation (1)
- alpha galactosidase (1)
- alpha-galactosidase-A (1)
- alpha/delta agonist GFT505 (1)
- amphiphilic block copolymer (1)
- anaemia (1)
- anatomy (1)
- anemia (1)
- animal model (1)
- animal models of human disease (1)
- antagonist (1)
- anti-drug antibodies (1)
- anti-myocardial (1)
- antibiotic prescription (1)
- antibodies (1)
- anticoagulation (1)
- antidiabetic agents (1)
- antimicrobial stewardship (1)
- antiphospholipid syndrome (1)
- antiretroviral therapy (1)
- antiretrovirals (1)
- anti‐SARS‐CoV‐2‐spike IgG (1)
- aorta (1)
- aortic valve (1)
- aortic valve disease (1)
- aortic valve disease percutaneous intervention (AVDP) (1)
- aortic valve stenosis (1)
- aortic valve stenosis (AS) (1)
- apolipoprotein E (1)
- apolipoprotein-E (1)
- apoptosis (1)
- arial fibrillation (1)
- arrhythmogenic cardiomyopathy (1)
- arterial elasticity (1)
- arterial stiffening (1)
- assay systems (1)
- astrocytoma (1)
- at-home sampling (1)
- atheriosclerosis (1)
- atherogenic dyslipidaemia (1)
- atherosclerosis risk (1)
- atrial fibrillation (1)
- atypical (1)
- autoantibodies (1)
- autoantibody (1)
- autonomous cortisol secretion (1)
- avascular necrosis (1)
- awareness (1)
- balance (1)
- bardoxolone methyl (1)
- battery depletion (1)
- behavior (1)
- biocompatibility (1)
- bioinformatic clustering (1)
- biological models (1)
- biomarker prediction (1)
- biopsy (1)
- biopsy findings (1)
- blood coagulation factor XIII (1)
- blood plasma (1)
- blood pressure monitoring (1)
- blood-glucose control (1)
- blood–brain barrier (1)
- bone formation (1)
- bone metabolism (1)
- bone mineral density (1)
- brain natriuretic peptide (1)
- brain pathology (1)
- branched-chain amino acids (1)
- bull’s eye plot (1)
- buparlisib (1)
- c-MYC (1)
- calcineurin signaling cascade (1)
- calcium (1)
- calcium imaging (1)
- canagliflozin (1)
- cancer detection (1)
- cancer diagnosis (1)
- cancer risk (1)
- cancer risk factors (1)
- cancer types (1)
- cancer-testis antigens (1)
- candidate genes (1)
- carcinogenesis (1)
- carcinoma (1)
- carcinoma metastases to pancreas (1)
- cardiac amyloidosis (1)
- cardiac arrest (1)
- cardiac dysfunction (1)
- cardiac energy metabolism (1)
- cardiac function (1)
- cardiac implantable electronic devices (CIED) (1)
- cardiac implants (1)
- cardiac magnetic resonance (1)
- cardiac pacing (1)
- cardiac resynchronization therapy (CRT) (1)
- cardiac thrombi (1)
- cardiac training group (1)
- cardiac transplantation (1)
- cardiac ventricles (1)
- cardiogenetics (1)
- cardiomyopathies (1)
- cardiopulmonary bypass (1)
- cardiovascular MRI (1)
- cardiovascular care (1)
- cardiovascular death (1)
- cardiovascular drugs (1)
- cardiovascular magnetic-resonance (1)
- cardiovascular mortality (1)
- cardiovascular munster procam (1)
- cardiovascular outcomes (1)
- cardiovascularm disease (1)
- carotid artery disease (1)
- case report (1)
- caspase-3 (1)
- catenin (1)
- catheter tip (1)
- cell biology (1)
- cell cultures (1)
- cell fusion (1)
- cell staining (1)
- cells (1)
- cellular physiology (1)
- central nervous system (1)
- cerebrovascular diseases (1)
- channel transport (1)
- checkpoint inhibitors (1)
- child (1)
- cholesterol (1)
- cholesterol metabolism (1)
- chromosomes (1)
- chronic distress (1)
- chronic heart failure (CHF) (1)
- chronic kidney disease (CKD) (1)
- chronic myeloid leukemia (1)
- chronic thromboembolic pulmonary hypertension (1)
- chronotype (1)
- cigarette smoking (1)
- circadian rhythms (1)
- circadian therapy (1)
- circulating microRNA (1)
- classification (1)
- clearance (1)
- clinical (1)
- clinical data warehouse (1)
- clinical genetics (1)
- clinical manifestations (1)
- clinical routine data (1)
- clinical study (1)
- clinical systems (1)
- clinical trial (1)
- clonal hematopoiesis of indeterminate potential (1)
- cloning of putative human promoter sequence (1)
- closure AV fistula/AVM (CLAV) (1)
- coa reductase inhibitors (1)
- coagulation (1)
- coaptation line (1)
- coherent anti-Stokes Raman scattering (CARS) microscopy (1)
- colestilan (1)
- colloids (1)
- color-coded (1)
- combination (1)
- comorbidity (1)
- comparability (1)
- comparative genomic hybridization (1)
- complex (1)
- complex‐valued machine learning (1)
- complication (1)
- comprehensive psychosomatic assessment (1)
- computed tomography (1)
- confounders (1)
- congenital adrenal hyperplasia (1)
- consensus conference (1)
- contact force (1)
- contractility (1)
- converting enzyme-inhibition (1)
- cornea verticillata (1)
- coronary calcification (1)
- coronary-artery calcification (1)
- coronary-heart-disease (1)
- correction (1)
- cortical OAT1 (1)
- cortisol-producing adenoma (1)
- costs (1)
- creatine synthesis (1)
- creatinine (1)
- cryptogenic stroke (1)
- cyclic (1)
- cyclic nucleotides such as cyclic adenosine monophosphate (1)
- cytochrome P450 3A4 (CYP3A4) (1)
- cytoplasmic staining (1)
- cytosol (1)
- dabrafenib (1)
- data augmentation (1)
- data warehouse (1)
- death rates (1)
- deep-vein thrombosis (1)
- deficient mice (1)
- demography (1)
- desmin-related myopathy (1)
- desminopathy (1)
- desmocollin-2 (1)
- desmoglein-2 (1)
- deubiquitinases (1)
- dexamethasone suppression test (1)
- diabetes complications (1)
- diabetes insipidus (1)
- diabetes mellitus type 2 (1)
- diabetic cardiomyopathy (1)
- diabetic kidney disease (1)
- diabetic mouse (1)
- diabetic nephropathy (1)
- diagnosis in Fabry disease (1)
- diagnostic medicine (1)
- dialysate (1)
- dialyzer membrane (1)
- diastolic dysfunction (1)
- diastolic function (1)
- dietary approaches to stop hypertension (1)
- dietary sodium restriction (1)
- digital Health (1)
- digital phenotyping (1)
- digital subtraction angiography (1)
- dilated cardiomyopathy (1)
- dilated cardiomyopathy with ataxia (1)
- dimensions (1)
- disease (1)
- disease score (1)
- disease severity (1)
- dissection (1)
- distant metastases (1)
- dobutamine stress echocardiography (1)
- documentation quality (1)
- dogs (1)
- double knockout mice (1)
- double-blind (1)
- doule blind (1)
- down regulation (1)
- drug interaction (1)
- drug intoxication (1)
- drug monitoring (1)
- drug therapy (1)
- drug toxicity (1)
- drug transporter (1)
- drug treatment (1)
- drug–drug interactions (DDIs) (1)
- dynamic (1)
- dysfunction (1)
- early prognosis (1)
- early-stage osteonecrosis (1)
- ecological momentary assessment (1)
- ectopic (1)
- eculizumab (1)
- electronic data capture (1)
- electronic health records (1)
- electrophysiology (1)
- electroporation (1)
- empagliflozin (1)
- end stage renal disease (1)
- end-stage kidney disease (1)
- endocrine cancer (1)
- endocrinology (1)
- endogenous hypercortisolism (1)
- endothelial (1)
- endothelial cell interactions (1)
- endothelin-1 (1)
- endovascular (1)
- energy homeostasis (1)
- enoxaparin (1)
- entresto (1)
- entropy production (1)
- environmental health (1)
- environmental impact (1)
- eosinophils (1)
- epithelial markers (1)
- erythropoietin (1)
- euroaspire (1)
- evidence-based practice (1)
- expression (1)
- extended matching questions (1)
- extracellular matrix (1)
- extracellular matrix remodeling (1)
- fabry disease (1)
- factor XI (1)
- factor XII (1)
- failure (1)
- fall (1)
- fatal cardiovascular disease (1)
- fatty acids (1)
- fatty liver (1)
- feature selection (1)
- female Fabry patients (1)
- ferritin (1)
- fetuin A (1)
- fibroblast growth factor-23 (1)
- filamin-C (1)
- flow (1)
- flow dynamics (1)
- flow patterns (1)
- fluorescence resonance energy transfer (1)
- focal semental glomerulosclerosis (1)
- focused surgical approach (1)
- food consumption (1)
- fourth (1)
- fractionation membranev (1)
- fracture (1)
- fragmin (1)
- free energy (1)
- free light chains (1)
- functional magnetic resonance imaging (1)
- functional regurgitation (1)
- gastric cancer (1)
- gefitinib (1)
- gene (1)
- gene expression (1)
- gene variant (1)
- gene-environment interaction (1)
- gene-therapy (1)
- genetic analysis (1)
- genetic loci (1)
- genetic renal disease (1)
- genetically modified animals (1)
- genome-wide association study (1)
- genotype/phenotype correlation (1)
- genotyping (1)
- giant cell arteritis (1)
- glial damage (1)
- glial fibrillary acidic protein (1)
- glioblastoma (1)
- global outcomes (1)
- glomerular-filtration-rate (1)
- glomerulonephritis (1)
- glucocorticoid excess (1)
- glucocorticoid replacement (1)
- glucocorticoid replacement regimens (1)
- glucocorticoid replacement therapy (1)
- glucose homeostasis (1)
- glucose tolerance test (1)
- graft (1)
- graft versus host disease (1)
- green fluorescent protein (1)
- growth differentiation factor 15 (1)
- growth hormone deficiency (1)
- guideline implementation (1)
- guideline-directed medical therapy (1)
- gut microbiome (1)
- haemodiafiltration (1)
- haemodialysis (1)
- haplotype (1)
- hashimotos-thyroiditis (1)
- healing and remodelling processes (1)
- health care (1)
- health care research (1)
- health economics (1)
- health policy (1)
- health questionnaire (1)
- health risk assessment (1)
- healthcare workers (1)
- hearing loss (1)
- heart disease (1)
- heart failure training group (1)
- heart failure with mid-range ejection fraction (1)
- heart failure with reduced ejection fraction (1)
- heart rate (1)
- heme oxygenase-1 (1)
- hemoglobin (1)
- heodialysis patients (1)
- high denisty lipoprotein (1)
- high dose dexamethasone suppression test (1)
- high-dose atorvastatin (1)
- high-resolution analysis (1)
- hip fracture (1)
- histopathology (1)
- home telemonitoring (1)
- homeostasis (1)
- homeostasisIon channels (1)
- hormones (1)
- hospitalization (1)
- human behaviour (1)
- human serum albumin (1)
- hydroxy-dabrafenib (1)
- hypercholesterolemia (1)
- hyperosmolality (1)
- hyperparathyroidism (1)
- hyperphosphataemia (1)
- hypersensitivity (1)
- hyponatremia (1)
- hypopituitary patients (1)
- hypothalamic gene expression (1)
- iPSC-CMs (1)
- identical twins (1)
- idiopathic osteonecrosis (1)
- imaging (1)
- imaging TTE/TEE (ITTE) (1)
- immune check inhibitor (1)
- immune checkpoint inhibitor (ICI) (1)
- immune-related adverse events (1)
- immunity (1)
- immuno-modulation (1)
- immunoassays (1)
- immunofluorescence (1)
- immunohistochemistry techniques (1)
- immunosenescence (1)
- immunotherapy-induced hypophysitis (1)
- implantable cardioverter defibrillator (ICD) (1)
- implantation (1)
- in silico analysis (1)
- in vivo (1)
- inappropriate prescription (1)
- incidence (1)
- incremental cost-effectiveness ratio (ICER) (1)
- indoxyl sulfate (1)
- induced insulin-release (1)
- inebilizumab (1)
- infarction size (1)
- infection (1)
- infections (1)
- inflammaging (1)
- information extraction (1)
- inherited metabolic disorders (1)
- inos (1)
- insufficiency (1)
- insulin tolerance test (1)
- intake (1)
- intensive care medicine (1)
- intensive care transport (1)
- intensive glucose control (1)
- interhospital transfer (1)
- interleukin-6 (1)
- interleukin-8 (1)
- intermediate filaments (1)
- interparticle interaction (1)
- intragastric balloon (1)
- ionic strength (1)
- ipilimumab (1)
- iron (1)
- ischemia (1)
- ischemia-reperfusion injury (1)
- ischemic (1)
- ischemic acute kidney injury model (1)
- isoproterenol (1)
- isturisa (1)
- italian population (1)
- kidney disease (1)
- kidney disease; (1)
- kidney ischemia/reperfusion injury (1)
- kidney-disease CKD (1)
- kinase (1)
- kinase inhibitors (1)
- kinases (1)
- lactase persistence (1)
- lactic acidosis (1)
- lactose (1)
- large animal models (1)
- late gadolinium enhancement (1)
- laxative (1)
- leaflet (1)
- left lateral wall (1)
- left ventricular geometric abnormality (1)
- left ventricular geometry (1)
- left ventricular mass index (1)
- left ventricular performance (1)
- left ventricular remodeling (1)
- left ventricular thrombusv (1)
- left-ventricular hypertrophy (1)
- leptin system (1)
- lesion formation (1)
- lesion size (1)
- lesions (1)
- leukocyte adhesion (1)
- leukocytes (1)
- lifestyle (1)
- linkage (1)
- lipid droplets (1)
- lipid-lowering therapy (1)
- lipoprotein apheresis (1)
- lipoprotein(a) (1)
- lipoxygenase (1)
- liquid chromatography tandem mass spectrometry (LC-MS/MS (1)
- liquid chromatography–tandem mass spectrometry (LC–MS/MS) (1)
- livin (1)
- lncRNA (1)
- long-term ventilation (1)
- longitudinal studies (1)
- loss (1)
- low molecular weight (1)
- low-gradient AS (1)
- lower limit of normal (1)
- lung cancer (1)
- lymph node dissection (1)
- lymph nodes (1)
- lymphadenectomy (1)
- lysosomal storage disorder (1)
- lyso‐Gb3 (1)
- m exercise training (1)
- mHealth (1)
- macrovascular (1)
- magnetic resonance (1)
- magnetic resonance spectroscopy (1)
- magnetic resonsance imaging (1)
- malignant tumors (1)
- malnutrition (1)
- marrow (1)
- mass spectrometry (1)
- mass spectronomy (1)
- meat (1)
- medical data integration center (1)
- medical dialysis (1)
- medical informatics initiative (1)
- medical students (1)
- medical therapy (1)
- medication extraction (1)
- medium cut-off dialyzer (1)
- medullary thyroid cancer (1)
- men born (1)
- menopause (1)
- mental impairment (1)
- mesenchymal markers (1)
- meta-analysis (1)
- metabolically unhealthy obesity (1)
- metabolism (1)
- metachronous (1)
- metastasis (1)
- metastatic (1)
- metformin (1)
- metyrapone (1)
- miR-182-5p (1)
- miR-183 cluster (1)
- miR-483-5p (1)
- mices (1)
- microscopy (1)
- microvascular (1)
- mild (1)
- mineral bone density (1)
- mineralocorticoid antagonist (1)
- minerals (1)
- mitochondria (1)
- mitochondria function and morphology (1)
- mitochondrial mRyR1 (1)
- mitofusin 2 (1)
- mitral valve (1)
- mobile crowdsensing (1)
- mobile health (1)
- model (1)
- modified-release hydrocortisone (1)
- molecular biology (1)
- molecular diagnostics (1)
- molecular medicine (1)
- monocytes (1)
- motion detector (1)
- multi-tyrosine kinase inhibitor (1)
- multidetector computed-tomography (1)
- multiple choice questions (1)
- multiple sclerosis (1)
- multivariate data analysis (1)
- mutation (1)
- mutation databases (1)
- mutation triggers (1)
- mutations (1)
- myocardial aging (1)
- myocardial lipid content (1)
- myocardial work efficiency (1)
- myocardial fibrosis (1)
- myocardial-infarction (1)
- myocardium (1)
- natural history (1)
- natural-history data (1)
- nerve fibers (1)
- neural networks (1)
- neuroblastoma – diagnosis (1)
- neurofibromatosis type 1 (1)
- neuroinflammation (1)
- neurological (1)
- neurological complications (1)
- neurology (1)
- neuromyelitis optica spectrum disorders (1)
- neurons (1)
- neuropathy (1)
- neuroscience (1)
- neutral loss (1)
- neutrophils (1)
- nictric-oxide (1)
- nitric oxide (1)
- nitric oxide synthase (1)
- nivolumab (1)
- non-equilibrium thermodynamics (1)
- non-triggered (1)
- noncontact monitoring (1)
- nontraumatic osteonecrosis of the femoral head (1)
- normal adrenal glands (1)
- normal values (1)
- notch signaling (1)
- nuclear staining (1)
- nutritional counseling (1)
- nutritional medical needs (1)
- nutritional risk screening (1)
- obesity surgery (1)
- observational study (1)
- occupational-status (1)
- oligonucleotides (1)
- on-site examination (1)
- oncology (1)
- oncology outpatients (1)
- openEHR (1)
- operation (1)
- opossum kidney cells (1)
- oral glucose (1)
- organoid (1)
- oscillating biomagnetic fields (1)
- osilodrostat (1)
- osimertinib (1)
- osmotic stimulation (1)
- osteocalcin (1)
- outcome (1)
- overload (1)
- p-cresyl sulfate (1)
- paired (1)
- pandemia (1)
- panel (1)
- papillary (1)
- papillary thyroid carcinoma (PTC) (1)
- parallel imaging (1)
- parathyroid adenoma (1)
- parathyroid carcinoma (1)
- parathyroid hormone (1)
- paravalvular regurgitation (1)
- pathogenesis (1)
- pathophysiology (1)
- patient survival (1)
- patients’ awareness (1)
- pediatric (1)
- pediatric adrenocortical adenoma (1)
- pediatric adrenocortical carcinoma (1)
- peptide tyrosine tyrosine 3-36 (PYY3-36) (1)
- peptide tyrosine tyrosine 3-36 (PYY\(_{3-36}\)) (1)
- percutaneous valve therapy (PVT) (1)
- perioperative chemotherapy (1)
- peritoneal carcinomatosis (1)
- personalised medicine (1)
- personalized antimicrobial therapy (1)
- personalized medicine (1)
- personalized treatment (1)
- pharmacoepidemiology (1)
- pharmacokinetics (1)
- pharmacotherapy (1)
- phase IV (1)
- phase-contrast CMR (1)
- phase-contrast MRI (1)
- pheochromocytoma/paraganglioma (1)
- phosphate homeostasis (1)
- phosphatidylcholines (1)
- phospholipid fatty acids (1)
- phosphorylated tau protein (1)
- phosphorylation (1)
- physical activity (1)
- physicians’ awareness (1)
- physiologically based pharmacokinetic (PBPK) modeling (1)
- pig (1)
- pioglitazone (1)
- piperacillin/tazobactam (1)
- pituitary (1)
- pituitary adenomas (1)
- pituitary gland (1)
- placebo (1)
- plant-derived metabolites (1)
- plaque (1)
- plaque characteristics (1)
- plasma (1)
- plasma NMR (1)
- plasma proteins (1)
- plasmid construction (1)
- platelet adhesion (1)
- platelets (1)
- pleural mesothelioma (1)
- podocyte (1)
- polarization (1)
- poly(2-oxazoline) (1)
- polyglandular autoimmune syndrome (1)
- polymorphism (1)
- polymyalgia rheumatica (1)
- population pharmacokinetics (1)
- population-based (1)
- population-based study (1)
- posaconazole (1)
- post-traumatic stress disorder (1)
- postoperativ (1)
- posttraumatische Belastungsstörung (1)
- poultry (1)
- preanalytical conditions (1)
- preclinical research (1)
- prediction model (1)
- predictive marker (1)
- premature mortality (1)
- preserved ejection fraction (1)
- preventive medicine (1)
- primary aldosteronism (1)
- primary healthcare (1)
- primary hyperparathyroidism (1)
- primary hypophysitis (1)
- primary polydipsia (1)
- prognostic biomarker (1)
- prognostic markers (1)
- progression (1)
- propionic acid (1)
- prospective (1)
- prostaglandin e2 (1)
- prostate cancer (1)
- protein binding (1)
- protein expression (1)
- protein-bound solutes (1)
- protein-bound uremic toxins (1)
- proteomic (1)
- pseudo-severe AS (1)
- psychiatric disorders (1)
- psychopharmacology (1)
- psychotherapy (1)
- public health (1)
- pulmonary artery pressure (1)
- pulmonary cancer (1)
- pulse-wave velocity (1)
- quantitative MRI (1)
- radical resection (1)
- radii (1)
- radiofrequency ablation (1)
- radioiodine (1)
- radioiodine therapy (1)
- radiotherapy (1)
- randomized controlled-trial (1)
- randomized trial (1)
- rare diseases (1)
- rat kidney (1)
- ravulizumab (1)
- real-world (1)
- rearranged during transfection (1)
- recombination hotspot (1)
- recommendations (1)
- recovery (1)
- recurrence free survival (1)
- recurrence survival (1)
- recurrence-free survival (1)
- recurrent Tako-Tsubo cardiomyopathy (1)
- reference data (1)
- refugee healthcare (1)
- regression analysis (1)
- regulation of expression (1)
- regurgitation (1)
- remote monitoring (1)
- removal (1)
- renal artery (1)
- renal disease (1)
- renal dysfunction (1)
- renal fibrosis (1)
- renal osteodystrophy (1)
- renal replacement therapy (1)
- renal system (1)
- renoprotection (1)
- repeated (1)
- repeated surgery (1)
- reperfusion (1)
- replacement therapy (1)
- reporter gen assay (1)
- reproductive disorders (1)
- research infrastructure (1)
- residual cardiovascular risk (1)
- respiratory signs and symptoms (1)
- retrospective (1)
- review (1)
- re‐transplantation (1)
- rheumatoid arthritis (1)
- right ventricular dysfunction (1)
- risk (1)
- risk factor control (1)
- risk prediction scores (1)
- rodent model (1)
- root (1)
- ruxolitinib (1)
- rygb (1)
- sacubitril-valsartan (1)
- sarcoidosis (1)
- satralizumab (1)
- scale (1)
- sclerostin (1)
- secondary data usage (1)
- secondary prevention (1)
- segmentation (1)
- self-gating (1)
- self-navigation (1)
- selpercatinib (1)
- semantic interoperability (1)
- septal hypertrophy (1)
- sequence databases (1)
- seroprevalence (1)
- serotonin (1)
- serotonin transporter deficient mice (1)
- serum (1)
- serum creatinine (1)
- sevelamer (1)
- severe renal insufficiency (1)
- sex addiction (1)
- sex differences (1)
- shear stress (1)
- shimming (1)
- short Synacthen test (1)
- short term (1)
- short-chain fatty acids (1)
- signal voids (1)
- signs (1)
- signs and symptoms (1)
- single nucleotide polymorphisms (1)
- skin diseases (1)
- sleeve gastrectomy (1)
- small animal (1)
- smoking (1)
- sodium (1)
- sodium-glucose co-transporter-2 inhibitors (1)
- solubility enhancement (1)
- somatic mutations (1)
- somatostatin receptor (1)
- speckle tracking imaging (1)
- speech recognition (1)
- sphingolipids (1)
- spin lock (1)
- spin-lock (1)
- spironolactone (1)
- sports and exercise medicine (1)
- standard heparin (1)
- standardization (1)
- state space (1)
- statement (1)
- statins (1)
- statistical mechanics (1)
- stenosis (1)
- steroid measurement (1)
- stress instructions (1)
- subjective health-status (1)
- sudden death (1)
- sulfonylurea (1)
- super-obesity (1)
- surgical and invasive medical procedures (1)
- surgical oncology (1)
- surgical repair (1)
- surgical treatment (1)
- surveillance (1)
- susceptibility (1)
- symptoms (1)
- systemic micro-inflammation oxidative stress (1)
- systems biology (1)
- t-lymphocytes (1)
- target therapies (1)
- targeted gene panel (1)
- targeted metabolomics (1)
- targeted therapy (1)
- targeted treatment (1)
- task force (1)
- telemedicine (1)
- telomeres (1)
- temperature (1)
- tenting (1)
- term fenofibrate therapy (1)
- therapeutic approach (1)
- therapeutic management (1)
- therapeutic options (1)
- thermodynamics (1)
- third (1)
- three-dimensional echocardiography (1)
- thromboinflammation (1)
- thrombopoiesis (1)
- thyroid carcinoma (TC) (1)
- tight junctions (1)
- timing (1)
- tissue (1)
- tocilizumab (1)
- tomography (1)
- trametinib (1)
- transcatheter valveimplantation (TVI) (1)
- transfection (1)
- transfer learning (1)
- transgenic rats (1)
- translation (1)
- translational research (1)
- transport experiments (1)
- treatment outcome (1)
- trial design (1)
- tricuspid pressure gradient (1)
- triglyceride-rich lipoproteins (1)
- troponin T (1)
- tumor (1)
- tumor microenvironment (1)
- tumor-infiltrating (1)
- tumors (1)
- type 2 (1)
- type-1 diabetes mellitus (1)
- type-2 diabetes mellitus (1)
- tyrosine kinase inhibitor (TKI) (1)
- tyrosine kinase inhibitors (1)
- ublituximab (1)
- ultrahigh field (1)
- ultrahigh-field (1)
- ultrahigh-field MRI (1)
- unfractionated heparin (1)
- univentricular heart (1)
- unsupervised clustering (1)
- uremic toxin (1)
- urinary protein excretion (1)
- usability (1)
- use (1)
- user-centered design (1)
- validity (1)
- variant (1)
- vascular calcification (1)
- vascular surgery (1)
- vemurafenib (1)
- ventricular tachycardia (1)
- vertigo (1)
- viral infection (1)
- vitamins (1)
- volume (1)
- volumetric absorptive micro-sampling (VAMS) (1)
- weaning (1)
- whole exome sequencing (1)
- wires (1)
- yellow fluorescent protein (1)
- zebrafish (1)
- α-galactosidase A (1)
- α‐GalA 3D‐structure (1)
Institute
- Medizinische Klinik und Poliklinik I (333) (remove)
Sonstige beteiligte Institutionen
- Zentraleinheit Klinische Massenspektrometrie (4)
- Apotheke, Universitätsklinikum Würzburg (1)
- Center for Interdisciplinary Clinical Research, Würzburg University, Würzburg, Germany (1)
- Datenintegrationszentrum Würzburg (DIZ) (1)
- Interdisziplinäre Biomaterial- und Datenbank Würzburg (ibdw) (1)
- Interdisziplinäres Amyloidosezentrum Nordbayern (1)
- Johns Hopkins School of Medicine (1)
- Johns Hopkins University School of Medicine (1)
- Klinische Studienzentrale (Universitätsklinikum) (1)
- Krankenhaushygiene und Antimicrobial Stewardship, Universitätsklinikum Würzburg (1)
Thermodynamics of Competitive Molecular Channel Transport: Application to Artificial Nuclear Pores
(2010)
In an analytical model channel transport is analyzed as a function of key parameters, determining efficiency and selectivity of particle transport in a competitive molecular environment. These key parameters are the concentration of particles, solvent-channel exchange dynamics, as well as particle-in-channel- and interparticle interaction. These parameters are explicitly related to translocation dynamics and channel occupation probability. Slowing down the exchange dynamics at the channel ends, or elevating the particle concentration reduces the in-channel binding strength necessary to maintain maximum transport. Optimized in-channel interaction may even shift from binding to repulsion. A simple equation gives the interrelation of access dynamics and concentration at this transition point. The model is readily transferred to competitive transport of different species, each of them having their individual in-channel affinity. Combinations of channel affinities are determined which differentially favor selectivity of certain species on the cost of others. Selectivity for a species increases if its in-channel binding enhances the species’ translocation probablity when compared to that of the other species. Selectivity increases particularly for a wide binding site, long channels, and fast access dynamics. Recent experiments on competitive transport of in-channel binding and inert molecules through artificial nuclear pores serve as a paradigm for our model. It explains qualitatively and quantitatively how binding molecules are favored for transport at the cost of the transport of inert molecules.
Background: Adrenocortical carcinoma (ACC) is a rare tumor with a poor prognosis. Often, the physicians who first treat patients with ACC have no prior experience with the disease. The aim of our study was to evaluate the quality of medical care for patients with ACC in Germany.
Methods: Data from the German ACC registry were analyzed with regard to the patients’ preoperative diagnostic evaluation, histopathological reporting, and clinical followup. The findings were compared with the recommendations of the European Network for the Study of Adrenal Tumors (ENSAT).
Results: Data were analyzed from 387 patients who had been given an initial diagnosis of ACC in the years 1998 to 2009. 21% of them underwent no hormonal evaluation before surgery, and 59% underwent an inadequate hormonal evaluation. This exposed the patients to unnecessary perioperative risks and impaired their follow-up. 48% did not undergo CT scanning of the chest, even though the lungs are the most frequent site of metastases of ACC. For 13% of the patients, the diagnosis of ACC was later revised by a reference pathologist. For 11% of the patients, the histopathology report contained no information about resection status, even though this is an important determinant of further treatment and prognosis. Optimal management requires re-staging at three-month intervals, yet some patients underwent re-staging only after a longer delay, or not at all.
Conclusion: We have identified significant deficits in the care of patients with ACC in Germany. We suspect that the situation is similar for other rare diseases. The prerequisite to better care is close and early cooperation of the treating physicians with specialized centers.
Context:
Adrenal tumors have a prevalence of around 2% in the general population. Adrenocortical carcinoma (ACC) is rare but accounts for 2–11% of incidentally discovered adrenal masses. Differentiating ACC from adrenocortical adenoma (ACA) represents a diagnostic challenge in patients with adrenal incidentalomas, with tumor size, imaging, and even histology all providing unsatisfactory predictive values.
Objective:
Here we developed a novel steroid metabolomic approach, mass spectrometry-based steroid profiling followed by machine learning analysis, and examined its diagnostic value for the detection of adrenal malignancy.
Design:
Quantification of 32 distinct adrenal derived steroids was carried out by gas chromatography/mass spectrometry in 24-h urine samples from 102 ACA patients (age range 19–84 yr) and 45 ACC patients (20–80 yr). Underlying diagnosis was ascertained by histology and metastasis in ACC and by clinical follow-up [median duration 52 (range 26–201) months] without evidence of metastasis in ACA. Steroid excretion data were subjected to generalized matrix learning vector quantization (GMLVQ) to identify the most discriminative steroids.
Results:
Steroid profiling revealed a pattern of predominantly immature, early-stage steroidogenesis in ACC. GMLVQ analysis identified a subset of nine steroids that performed best in differentiating ACA from ACC. Receiver-operating characteristics analysis of GMLVQ results demonstrated sensitivity = specificity = 90% (area under the curve = 0.97) employing all 32 steroids and sensitivity = specificity = 88% (area under the curve = 0.96) when using only the nine most differentiating markers.
Conclusions:
Urine steroid metabolomics is a novel, highly sensitive, and specific biomarker tool for discriminating benign from malignant adrenal tumors, with obvious promise for the diagnostic work-up of patients with adrenal incidentalomas.
Background:
Oncolytic viral therapy represents an alternative therapeutic strategy for the treatment of cancer. We previously described GLV-1h68, a modified Vaccinia Virus with exclusive tropism for tumor cells, and we observed a cell line-specific relationship between the ability of GLV-1h68 to replicate in vitro and its ability to colonize and eliminate tumor in vivo.
Methods:
In the current study we surveyed the in vitro permissivity to GLV-1h68 replication of the NCI-60 panel of cell lines. Selected cell lines were also tested for permissivity to another Vaccinia Virus and a vesicular stomatitis virus (VSV) strain. In order to identify correlates of permissity to viral infection, we measured transcriptional profiles of the cell lines prior infection.
Results:
We observed highly heterogeneous permissivity to VACV infection amongst the cell lines. The heterogeneity of permissivity was independent of tissue with the exception of B cell derivation. Cell lines were also tested for permissivity to another Vaccinia Virus and a vesicular stomatitis virus (VSV) strain and a significant correlation was found suggesting a common permissive phenotype. While no clear transcriptional pattern could be identified as predictor of permissivity to infection, some associations were observed suggesting multifactorial basis permissivity to viral infection.
Conclusions:
Our findings have implications for the design of oncolytic therapies for cancer and offer insights into the nature of permissivity of tumor cells to viral infection.
Aim
To investigate whether diagnostic data from implanted cardiac resynchronization therapy defibrillators (CRT-Ds) retrieved automatically at 24 h intervals via a Home Monitoring function can enable dynamic prediction of cardiovascular hospitalization and death.
Methods and results
Three hundred and seventy-seven heart failure patients received CRT-Ds with Home Monitoring option. Data on all deaths and hospitalizations due to cardiovascular reasons and Home Monitoring data were collected prospectively during 1-year follow-up to develop a predictive algorithm with a predefined specificity of 99.5%. Seven parameters were included in the algorithm: mean heart rate over 24 h, heart rate at rest, patient activity, frequency of ventricular extrasystoles, atrial–atrial intervals (heart rate variability), right ventricular pacing impedance, and painless shock impedance. The algorithm was developed using a 25-day monitoring window ending 3 days before hospitalization or death. While the retrospective sensitivities of the individual parameters ranged from 23.6 to 50.0%, the combination of all parameters was 65.4% sensitive in detecting cardiovascular hospitalizations and deaths with 99.5% specificity (corresponding to 1.83 false-positive detections per patient-year of follow-up). The estimated relative risk of an event was 7.15-fold higher after a positive predictor finding than after a negative predictor finding.
Conclusion
We developed an automated algorithm for dynamic prediction of cardiovascular events in patients treated with CRT-D devices capable of daily transmission of their diagnostic data via Home Monitoring. This tool may increase patients’ quality of life and reduce morbidity, mortality, and health economic burden, it now warrants prospective studies.
Two sons of a consanguineous marriage developed biventricular cardiomyopathy. One boy died of severe heart failure at the age of 6 years, the other was transplanted because of severe heart failure at the age of 10 years. In addition, focal palmoplantar keratoderma and woolly hair were apparent in both boys. As similar phenotypes have been described in Naxos disease and Carvajal syndrome, respectively, the genes for plakoglobin (JUP) and desmoplakin (DSP) were screened for mutations using direct genomic sequencing. A novel homozygous 2 bp deletion was identified in an alternatively spliced region of DSP. The deletion 5208_5209delAG led to a frameshift downstream of amino acid 1,736 with a premature truncation of the predominant cardiac isoform DSP-1. This novel homozygous truncating mutation in the isoform-1 specific region of the DSP C-terminus caused Carvajal syndrome comprising severe early-onset heart failure with features of non-compaction cardiomyopathy, woolly hair and an acantholytic form of palmoplantar keratoderma in our patient. Congenital hair abnormality and manifestation of the cutaneous phenotype in toddler age can help to identify children at risk for cardiac death.
Background:
Competing risks methodology allows for an event-specific analysis of the single components of composite time-to-event endpoints. A key feature of competing risks is that there are as many hazards as there are competing risks. This is not always well accounted for in the applied literature.
Methods:
We advocate a simulation point of view for understanding competing risks. The hazards are envisaged as momentary event forces. They jointly determine the event time. Their relative magnitude determines the event type. 'Empirical simulations' using data from a recent study on cardiovascular events in diabetes patients illustrate subsequent interpretation. The method avoids concerns on identifiability and plausibility known from the latent failure time approach.
Results:
The 'empirical simulations' served as a proof of concept. Additionally manipulating baseline hazards and treatment effects illustrated both scenarios that require greater care for interpretation and how the simulation point of view aids the interpretation. The simulation algorithm applied to real data also provides for a general tool for study planning.
Conclusions:
There are as many hazards as there are competing risks. All of them should be analysed. This includes estimation of baseline hazards. Study planning must equally account for these aspects.
Background:
To assess heart failure therapies in diabetic patients with preserved as compared to impaired systolic ventricular function.
Methods:
3304 patients with heart failure from 9 different studies were included (mean age 63 +/- 14 years); out of these, 711 subjects had preserved left ventricular ejection fraction (>= 50%) and 994 patients in the whole cohort suffered from diabetes.
Results:
The majority (>90%) of heart failure patients with reduced ejection fraction (SHF) and diabetes were treated with an ACE inhibitor (ACEi) or angiotensin receptor blocker (ARB) or with beta-blockers. By contrast, patients with diabetes and preserved ejection fraction (HFNEF) were less likely to receive these substance classes (p < 0.001) and had a worse blood pressure control (p < 0.001). In comparison to patients without diabetes, the probability to receive these therapies was increased in diabetic HFNEF patients (p < 0.001), but not in diabetic SHF patients. Aldosterone receptor blockers were given more often to diabetic patients with reduced ejection fraction (p < 0.001), and the presence and severity of diabetes decreased the probability to receive this substance class, irrespective of renal function.
Conclusions:
Diabetic patients with HFNEF received less heart failure medication and showed a poorer control of blood pressure as compared to diabetic patients with SHF. SHF patients with diabetes were less likely to receive aldosterone receptor blocker therapy, irrespective of renal function.
Aims
Sudden cardiac death (SCD) is a major contributor to the excess mortality of patients on maintenance dialysis. Homoarginine deficiency may lead to decreased nitric oxide availability and endothelial dysfunction. Based on this rationale we assessed whether homoarginine deficiency is a risk factor for SCD in dialysis patients.
Methods and results
This study examined the association of homoarginine with cardiovascular outcomes in 1255 diabetic haemodialysis patients from the German diabetes and dialysis study. During a median of 4 years of follow-up, hazard ratios (HR) (95% CI) for reaching the following pre-specified, adjudicated endpoints were determined: SCD, myocardial infarction, stroke, death due to heart failure, and combined cardiovascular events. There was a strong association of low homoarginine concentrations with the presence of congestive heart failure and left ventricular hypertrophy as well as increased levels of brain natriuretic peptide. Per unit decrease in homoarginine, the risk of SCD increased three-fold (HR 3.1, 95% CI 2.0–4.9), attenuating slightly in multivariate models (HR 2.4; 95% CI 1.5–3.9). Patients in the lowest homoarginine quintile experienced a more than two-fold increased risk of SCD, and more than three-fold increased risk of heart failure death than patients in the highest quintile, which accounted for the high incidence of combined cardiovascular events. Low homoarginine showed a trend towards increased risk of stroke, however, myocardial infarction was not meaningfully affected.
Conclusion
Low homoarginine is a strong risk factor for SCD and death due to heart failure in haemodialysis patients. Further studies are needed to elucidate the underlying mechanisms, offering the potential to develop new interventional strategies.