Refine
Has Fulltext
- yes (106) (remove)
Is part of the Bibliography
- yes (106)
Year of publication
Document Type
- Preprint (106) (remove)
Language
- English (106) (remove)
Keywords
- boron (20)
- Quran (8)
- diborenes (8)
- Koran (7)
- Text Mining (7)
- crystallization (6)
- carbenes (5)
- cosmology (5)
- qubit (5)
- Boron (4)
- Positronen-Emissions-Tomografie (4)
- XML (4)
- decoherence (4)
- Bayesian classifier (3)
- PET (3)
- Softwarearchitektur (3)
- Textvergleich (3)
- Visualisierung (3)
- Wissensmanagement (3)
- diboranes (3)
- diborene (3)
- low-valent compounds (3)
- prostate cancer (3)
- 18F-DCFPyL (2)
- Base text (2)
- CSS (2)
- Cascading Style Sheets (2)
- Content Management (2)
- DFT calculations (2)
- Diborane (2)
- Fluoreszenz (2)
- Gothenburg model (2)
- Knowledge Management (2)
- Maschinelles Lernen (2)
- Meta-model (2)
- N-heterocyclic carbenes (2)
- Nonadiabatic quantum dynamics (2)
- PSMA (2)
- PSMA-RADS (2)
- RADS (2)
- SSTR (2)
- Strahlungstransport (2)
- Supraleiter (2)
- Text mining (2)
- Textual alterations weighting system (2)
- Textual document collation (2)
- Visualization (2)
- Wrapper <Programmierung> (2)
- Zeitrichtung (2)
- bond activation (2)
- borylation (2)
- borylene (2)
- complexity (2)
- diborynes (2)
- emergent time (2)
- evolution (2)
- low-valent main group chemistry (2)
- modified inflation (2)
- multiple bonding (2)
- phase transition (2)
- prostate-specific membrane antigen (2)
- protein folding (2)
- qubit interaction (2)
- time-resolved photoelectron spectroscopy (2)
- transition metal complex (2)
- 1,2-additions (1)
- 2Dimensionale Spektroskopie (1)
- 3D cultures (1)
- 68Ga-DOTANOC (1)
- 68Ga-DOTATATE (1)
- 68Ga-DOTATOC (1)
- 7,8-dihydroxyflavone (7,8-DHF) (1)
- AMP-activated protein kinase (AMPK) (1)
- Analysis of RNA Modifications (1)
- Anorexia nervosa (1)
- Aromaticity (1)
- Barbituric Acid Merocyanines (1)
- Bayes-Klassifikator (1)
- Bedeutung (1)
- Beige adipocytes (1)
- Beobachter (1)
- Berechnungskomplexität (1)
- BioID (1)
- Biradicals (1)
- Bor (1)
- Boranes (1)
- Borylene (1)
- C-H activation (1)
- C/EBP (1)
- CH activation (1)
- CMR (1)
- CO activation (1)
- CO2 fixation (1)
- Causes of revelation (1)
- Chapters arrangement (1)
- Chemical Structure (1)
- Chronology of revelation (1)
- Clustering (1)
- Computational Chemistry (1)
- Computersimulation (1)
- Crystal structure of MTR1 (1)
- Cycloaddition (1)
- DFT mechanism (1)
- DNA (1)
- DNA catalyst (1)
- DNA-based nanostructures (1)
- DNA-processing enzymes (1)
- Deep learning (1)
- Diboranes (1)
- Diborene (1)
- Doppelquantenkohärenz (1)
- E8 symmetry (1)
- EEA (1)
- Entscheidung (1)
- Entscheidungen (1)
- Evolution (1)
- Excited state dynamics (1)
- Exciton (1)
- Exciton dynamics (1)
- Exciton localization dynamics (1)
- Exziton (1)
- Fragmentation (1)
- Fragmentierung (1)
- Frames (1)
- Fundamentalkonstante (1)
- Gothenburg Modell (1)
- Gothenburg model of collation process (1)
- Gödel (1)
- HHV-6 (1)
- HTML (1)
- Helicene diimide (1)
- Herpesvirus (1)
- High-Throughput Sequencing Method, DZ-seq (1)
- Higher-order Transient Absorption Spectroscopy (1)
- Hurwitz theorem (1)
- Hydrocarbon radicals (1)
- Hydrocarbons (1)
- Hydrogen (1)
- Information Visualization (1)
- Inverse Probleme (1)
- JSF (1)
- Java Frameworks (1)
- Knowledge Management System (1)
- Knowledge Modeling (1)
- Knowledge representation (1)
- Knowledge-based System (1)
- Kolmogorov-Komplexität (1)
- Komplex <Algebra> (1)
- Komplexität (1)
- Lawhul-Mahfuz (1)
- Lee Smolin (1)
- Lewis acids (1)
- Lewis-base adducts (1)
- Ljapunov-Funktion (1)
- Low energy electron microscopy LEEM (1)
- MI-RADS (1)
- MVC <Software> (1)
- Main-group chemistry (1)
- Mashup (1)
- Mashup <Internet> (1)
- Metadynamics (1)
- Metal clusters (1)
- Metallocene (1)
- Metallocenes (1)
- Methyltransferase Ribozyme (1)
- Methyltransferase Ribozyme MTR1 (1)
- Molekülzustand (1)
- Monte Carlo simulation (1)
- Multiple bonding (1)
- Multiple bonds (1)
- Myocardial infarction (1)
- N6-methyladenosine (1)
- N6-methyladenosine (m6A) (1)
- NMR spectroscopy (1)
- Natur (1)
- Nature constants (1)
- Naturgesetz (1)
- Natürliche Auslese (1)
- Naïve Bayesian (1)
- Nicht-Transparente Medien (1)
- Non-transparency (1)
- Nonadiabatic dynamics (1)
- Nucleobase Surrogate Incorporation (1)
- Optische Spektroskopie (1)
- Organoboron chemistry (1)
- Overlapping (1)
- PDXP inhibitors (1)
- PET/CT (1)
- PROMISE (1)
- PSMA-PET (1)
- PSMA-RADS-3A (1)
- PSMA-RADS-3B (1)
- PSMA-targeted PET (1)
- Pancreas (1)
- Photodynamics (1)
- Photoemission electron microscopy PEEM (1)
- Photoresponsive DNA Crosslinker (1)
- Physikalische Zeit (1)
- Place of revelation (1)
- Pontryagin maximum principle (1)
- Positron Emission Tomography (1)
- Processing Model (1)
- Processing model (1)
- Prostate Cancer (1)
- Protein kinase D1 (PKD1) (1)
- RNA (1)
- RNA Aptamer (1)
- RNA Enzymes (1)
- RNA modification (1)
- RNA-Cleaving Deoxyribozymes (1)
- RNA-catalyzed RNA methylation (1)
- Reconstruction of original text (1)
- Reference Architecture (1)
- Ribozyme-catalyzed RNA labeling (1)
- SQH method (1)
- SSTR-RADS (1)
- Scar (1)
- Scatter Plot (1)
- Segmentation (1)
- Singapore (1)
- Single-molecule microscopy (1)
- Software architecture (1)
- Software design (1)
- Spatially resolved 2D spectroscopy (1)
- Spektroskopie (1)
- Spring (1)
- Stages of Prophet Mohammad’s messengership (1)
- Stammzelle (1)
- Statistical classifiers (1)
- Streptavidin (1)
- Struts (1)
- Support Vector Machine (1)
- Tetrafluorodiborane (1)
- Text categorization (1)
- Text segmentation (1)
- Time hole (1)
- Time-resolved photoemission electron microscopy (1)
- Tolane-Modified Fluorescent Nucleosides (1)
- Transition metals (1)
- Two-color pump-probe spectroscopy (1)
- Ultrafast spectroscopy (1)
- Virchow Node (1)
- Visual Text Mining (1)
- Web service (1)
- Webservice Composition (1)
- Wissensbanksystem (1)
- Wissensrepräsentation (1)
- Wrapper (1)
- Wrappers (1)
- X-ray crystallography (1)
- XML model (1)
- YTH reader proteins (1)
- Zweidimensionale Spektroskopie (1)
- [177Lu]-DOTATATE/-DOTATOC (1)
- [68Ga] (1)
- alkene-alkyne [2+2] photocycloaddition (1)
- alkynes (1)
- amine borane dehydrocoupling (1)
- animal research (1)
- antibody fluorescence signals (1)
- atomic mutagenesis (1)
- attention (1)
- auditory (1)
- auditory domain (1)
- benzyl radical (1)
- bit (1)
- boron chains (1)
- boronium cations (1)
- borylenes (1)
- brain activity (1)
- carbohydrates (1)
- carbon dioxide (1)
- cardiomyocytes (1)
- carsharing (1)
- catalysis (1)
- chain structures (1)
- chalcogens (1)
- chelates (1)
- conewise linear systems (1)
- conical intersections (1)
- conjugation (1)
- converse Lyapunov theorems (1)
- covalent and site-specific RNA labeling (1)
- crystal growth (1)
- crystallography (1)
- cyclic (alkyl)(amino)carbene (1)
- cycloaddition (1)
- decision (1)
- demethylase enzymes FTO and ALKBH5 (1)
- density functional calculations (1)
- deoxyribozymes (1)
- desymmetrization (1)
- diboraindanes (1)
- diborane (1)
- diborane(6) (1)
- diboration (1)
- diboron (1)
- diboryne (1)
- diradicals (1)
- discrete-time systems (1)
- distance-based classifier (1)
- disturbance (1)
- early cosmology (1)
- electron donors (1)
- electrophiles (1)
- elektronisch angeregte Zustände (1)
- emergent gravity (1)
- energy transfer dynamics (1)
- erovalent diboron compounds (1)
- exciton dynamics (1)
- exciton-exciton (1)
- eye blinks (1)
- fatty acid (1)
- field-induced surface hopping (1)
- fine-tuning (1)
- fluorescence (1)
- fluorescence quantum yield (1)
- fluorescent protein (1)
- fluorescent resonance energy transfer (1)
- free movement (1)
- fusion and fission (1)
- gastrointestinal disease (1)
- half-sandwich complexes (1)
- helicobacter (1)
- heterocycles (1)
- heuristics (1)
- hiPSC-CM (1)
- hydration dynamics (1)
- hydroarylation (1)
- hydroboration (1)
- hydrogenation (1)
- immunofluorescence detection (1)
- in vitro selection (1)
- in vitro selection from a structured RNA library (1)
- induced pluripotent stem cells (1)
- inflammatory bowel disease (1)
- inflation (1)
- infrared-spectra (1)
- insertion (1)
- interactive collation of textual variants (1)
- intermolecular applications of ribozymes (1)
- interobserver (1)
- interreader (1)
- iodine (1)
- isomers (1)
- large Stokes shift (1)
- latency (1)
- ligand exchange (1)
- light-induced interstrand DNA crosslinking (1)
- loop quantum gravity (1)
- low-valent main-group species (1)
- main-group chemistry (1)
- mapping function (1)
- meaning (1)
- miR-30 (1)
- miRNA processing (1)
- microbiota (1)
- mitochondria (1)
- mobility (1)
- modified nucleosides (1)
- multiple bonds (1)
- multiverse (1)
- near-IR chromophores (1)
- neuroendocrine neoplasia (1)
- neuroendocrine tumor (1)
- nnU-net (1)
- non-smooth optimization (1)
- nonadiabatic dynamics (1)
- nonconvex optimization (1)
- norovirus (1)
- observer (1)
- oddball (1)
- organoid culture (1)
- phase space (1)
- photodynamics (1)
- physical time (1)
- pi-conjugation (1)
- position-specific installation of m1A in RNA (1)
- protein hydration (1)
- protein localization (1)
- pyrene dimer (1)
- pyridoxal phosphatase (PDXP) (1)
- quantum computing (1)
- rBAM2-labeled RNA strands (1)
- reactive intermediates (1)
- rearrangement (1)
- recording methods (1)
- redox reactions (1)
- reductive coupling (1)
- refeeding syndrome (1)
- reporting and data system (1)
- ring expansion (1)
- rotavirus (1)
- salmonella (1)
- selection (1)
- service based software architecture (1)
- service brokerage (1)
- silylenes (1)
- small HOMO-LUMO gap (1)
- small-molecule activation (1)
- somatostatin receptor (1)
- spectroscopy (1)
- squaraine polymer (1)
- stability analysis (1)
- standardized reporting (1)
- stem cell therapy (1)
- strained molecules (1)
- structural analysis (1)
- sustainability (1)
- synthesis (1)
- synthetic methods (1)
- taxi (1)
- text categorization (1)
- time hole (1)
- tracer (1)
- trans-acting 2'-5' adenylyl transferase ribozymes (1)
- trans-formanilide (1)
- transfer hydrogenation (1)
- transition metals (1)
- transport (1)
- tumor heterogeneity (1)
- type I interferon (1)
- unified theories (1)
- vegetarians (1)
- virtual reality (1)
- virus reactivation (1)
- visual (1)
- visual domain (1)
- vitamin B6 (1)
- water migration (1)
- Überlappung (1)
- β3 adrenergic receptor (ADRB3) (1)
Institute
- Institut für Anorganische Chemie (30)
- Institut für Physikalische und Theoretische Chemie (19)
- Institut für deutsche Philologie (17)
- Institut für Organische Chemie (14)
- Theodor-Boveri-Institut für Biowissenschaften (12)
- Klinik und Poliklinik für Nuklearmedizin (6)
- Physikalisches Institut (4)
- Rudolf-Virchow-Zentrum (4)
- Institut für Klinische Neurobiologie (2)
- Institut für Mathematik (2)
Sonstige beteiligte Institutionen
- Johns Hopkins School of Medicine (3)
- International Max Planck Research School Molecular Biology, University of Göttingen, Germany (2)
- Center for Nanoscale Microscopy and Molecular Physiology of the Brain (CNMPB), Göttingen, Germany (1)
- Center for Nanosystems Chemistry (CNC), University of Würzburg (1)
- Center for Nanosystems Chemistry (CNC), Universität Würzburg (1)
- Center for Nanosystems Chemistry (CNC), Universität Würzburg, Am Hubland, 97074 Würzburg, Germany (1)
- Center of Excellence for Science and Technology - Integration of Mediterranean region (STIM), Faculty of Science, University of Split, Poljička cesta 35, 2100 Split, Croatia (1)
- Charles University, Faculty of Mathematics and Physics, Ke Karlovu 5, 121 16 Prague, Czech Republic (1)
- Departamento de Química, Facultad de Ciencias, Universidad Autónoma de Madrid, 28049 Madrid, Spain (1)
- Department of Biomedical Imaging, National Cerebral and Cardiovascular Research Center, Suita, Japan (1)
Purpose: Prostate-specific membrane antigen (PSMA)-targeted positron emission tomography (PET) imaging has become commonly utilized in patients with prostate cancer (PCa). The PSMA reporting and data system version 1.0 (PSMA-RADS version 1.0) categorizes lesions on the basis of the likelihood of PCa involvement, with PSMA-RADS-3A (soft tissue) and PSMA-RADS-3B (bone) lesions being indeterminate for the presence of disease. We retrospectively reviewed the imaging follow-up of such lesions to determine the rate at which they underwent changes suggestive of underlying PCa.
Methods: PET/CT imaging with \(^{18}\)F-DCFPyL was carried out in 110 patients with PCa and lesions were categorized according to PSMA-RADS Version 1.0. 56/110 (50.9%) patients were determined to have indeterminate PSMA-RADS-3A or PSMA-RADS-3B lesions and 22/56 (39.3%) patients had adequate follow-up to be included in the analysis. The maximum standardized uptake values (SUV\(_{max}\)) of the lesions were obtained and the ratios of SUV\(_{max}\) of the lesions to SUV\(_{mean}\) of blood pool (SUV\(_{max}\)-lesion/SUV\(_{mean}\)-bloodpool) were calculated. Pre-determined criteria were used to evaluate the PSMA-RADS-3A and PSMA-RADS-3B lesions on follow-up imaging to determine if they demonstrated evidence of underlying malignancy.
Results: A total of 46 lesions in 22 patients were considered indeterminate for PCa (i.e. PSMA-RADS-3A (32 lesions) or PSMA-RADS-3B (14 lesions)) and were evaluable on follow-up imaging. 27/46 (58.7%) lesions demonstrated changes on follow-up imaging consistent with the presence of underlying PCa at baseline. These lesions included 24/32 (75.0%) PSMA-RADS-3A lesions and 3/14 (21.4%) lesions categorized as PSMA-RADS-3B. The ranges of SUVmax and SUVmax-lesion/SUVmean-bloodpool overlapped between those lesions demonstrating changes consistent with malignancy on follow-up imaging and those lesions that remained unchanged on follow-up.
Conclusion: PSMA-RADS-3A and PSMA-RADS-3B lesions are truly indeterminate in that proportions of findings in both categories demonstrate evidence of malignancy on follow-up imaging. Overall, PSMA-RADS-3A lesions are more likely than PSMA-RADS-3B lesions to represent sites of PCa and this information should be taken into when guiding patient therapy.
Most proteins work in aqueous solution and the interaction with water strongly affects their structure and function. However, experimentally the motion of a specific single water molecule is difficult to trace by conventional methods, because they average over the heterogeneous solvation structure of bulk water surrounding the protein. Here, we provide a detailed atomistic picture of the water rearrangement dynamics around the –CONH– peptide linkage in the two model systems formanilide and acetanilide, which simply differ by the presence of a methyl group at the peptide linkage. The combination of picosecond pump–probe time-resolved infrared spectroscopy and molecular dynamics simulations demonstrates that the solvation dynamics at the molecular level is strongly influenced by this small structural difference. The effective timescales for solvent migration triggered by ionization are mainly controlled by the efficiency of the kinetic energy redistribution rather than the shape of the potential energy surface. This approach provides a fundamental understanding of protein hydration and may help to design functional molecules in solution with tailored properties.
Excitation energy transport in DNA modelled by multi-chromophoric field-induced surface hopping
(2020)
Absorption of ultraviolet light is known as a major source of carcinogenic mutations of DNA. The underlying processes of excitation energy dissipation are yet not fully understood. In this work we provide a new and generally applicable route for studying the excitation energy transport in multi-chromophoric complexes at an atomistic level. The surface-hopping approach in the frame of the extended Frenkel exciton model combined with QM/MM techniques allowed us to simulate the photodynamics of the alternating (dAdT)10 : (dAdT)10 double-stranded DNA. In accordance with recent experiments, we find that the excited state decay is multiexponential, involving a long and a short component which are due to two distinct mechanisms: formation of long-lived delocalized excitonic and charge transfer states vs. ultrafast decaying localized states resembling those of the bare nucleobases. Our simulations explain all stages of the ultrafast photodynamics including initial photoexcitation, dynamical evolution out of the Franck-Condon region, excimer formation and nonradiative relaxation to the ground state.
Purpose: Early identification of aggressive disease could improve decision-support in pancreatic neuroendocrine tumor (pNET) patients prior to peptide receptor radionuclide therapy (PRRT). The prognostic value of intratumoral textural features (TF) determined by baseline somatostatin receptor (SSTR)-PET before PRRT was analyzed.
Procedures: 31 patients with G1/G2 pNET were enrolled (G2, n=23/31). Prior to PRRT with [\(^{177}\)Lu]DOTATATE (mean, 3.6 cycles), baseline SSTR-PET/CT was performed. By segmentation of 162 (median per patient, 5) metastases, intratumoral TF were computed. The impact of conventional PET parameters (SUV\(_{mean/max}\)), imaging-based TF as well as clinical parameters (Ki67, CgA) for prediction of both progression-free (PFS) and overall survival (OS) after PRRT was evaluated.
Results: Within a median follow-up of 3.7y, tumor progression was detected in 21 patients (median, 1.5y) and 13/31 deceased (median, 1.9y). In ROC analysis, the TF Entropy, reflecting derangement on a voxel-by-voxel level, demonstrated predictive capability for OS (cutoff=6.7, AUC=0.71, p=0.02). Of note, increasing Entropy could predict a longer survival (>6.7, OS=2.5y, 17/31), whereas less voxel-based derangement portended inferior outcome (<6.7, OS=1.9y, 14/31). These findings were supported in a G2 subanalysis (>6.9, OS=2.8y, 9/23 vs. <6.9, OS=1.9y, 14/23). Kaplan-Meier analysis revealed a significant distinction between high- and low-risk groups using Entropy (n=31, p<0.05). For those patients below the ROC-derived threshold, the relative risk of death after PRRT was 2.73 (n=31, p=0.04). Ki67 was negatively associated with PFS (p=0.002); however, SUVmean/max failed in prognostication (n.s.).
Conclusions: In contrast to conventional PET parameters, assessment of intratumoral heterogeneity demonstrated superior prognostic performance in pNET patients undergoing PRRT. This novel PET-based strategy of outcome prediction prior to PRRT might be useful for patient risk stratification.
Objectives: Recently, the standardized reporting and data system for prostate-specific membrane antigen (PSMA)-targeted positron emission tomography (PET) imaging studies, termed PSMA-RADS version 1.0, was introduced. We aimed to determine the interobserver agreement for applying PSMA-RADS to imaging interpretation of 18F-DCFPyL PET examinations in a prospective setting mimicking the typical clinical work-flow at a prostate cancer referral center.
Methods: Four readers (two experienced readers (ER, > 3 years of PSMA-targeted PET interpretation experience) and two inexperienced readers (IR, < 1 year of experience)), who had all read the initial publication on PSMA-RADS 1.0, assessed 50 18F-DCFPyL PET/computed tomography (CT) studies independently. Per scan, a maximum of 5 target lesions were selected by the observers and a PSMA-RADS score for every target lesion was recorded. No specific pre-existing conditions were placed on the selection of the target lesions, although PSMA-RADS 1.0 suggests that readers focus on the most highly avid or largest lesions. An overall scan impression based on PSMA-RADS was indicated and interobserver agreement rates on a target lesion-based, on an organ-based, and on an overall PSMA-RADS score-based level were computed.
Results: The number of target lesions identified by each observer were as follows: ER 1, 123; ER 2, 134; IR 1, 123; and IR 2, 120. Among those selected target lesions, 125 were chosen by at least two individual observers (all four readers selected the same target lesion in 58/125 (46.4%) instances, three readers in 40/125 (32%) and two observers in 27/125 (21.6%) instances). The interobserver agreement for PSMA-RADS scoring among identical target lesions was good (intraclass correlation coefficient (ICC) for four, three and two identical target lesions, ≥0.60, respectively). For lymph nodes, an excellent interobserver agreement was derived (ICC=0.79). The interobserver agreement for an overall scan impression based on PSMA-RADS was also excellent (ICC=0.84), with a significant difference for ER (ICC=0.97) vs. IR (ICC=0.74, P=0.005).
Conclusions: PSMA-RADS demonstrates a high concordance rate in this study, even among readers with different levels of experience. This suggests that PSMA-RADS can be effectively used for communication with clinicians and can be implemented in the collection of data for large prospective trials.
Standardized reporting is more and more routinely implemented in clinical practice and such structured reports have a major impact on a large variety of medical fields, e.g. laboratory medicine, pathology, and, recently, radiology. Notably, the field of nuclear medicine is constantly evolving, as novel radiotracers for numerous clinical applications are developed. Thus, framework systems for standardized reporting in this field may a) increase clinical acceptance of new radiotracers, b) allow for inter- and intra-center comparisons for quality assurance, and c) may be used in (global) multi-center studies to ensure comparable results and enable efficient data abstraction. In the last two years, several standardized framework systems for positron emission tomography (PET) radiotracers with potential theranostic applications have been proposed. These include systems for prostate-specific membrane antigen (PSMA)-targeted PET agents for the diagnosis and treatment of prostate cancer (PCa) and somatostatin receptor (SSTR)-targeted PET agents for the diagnosis and treatment of neuroendocrine neoplasias. In the present review, those standardized framework systems for PSMA- and SSTR-targeted PET will be briefly introduced followed by an overview of their advantages and limitations. In addition, potential applications will be defined, approaches to validate such concepts will be proposed, and future perspectives will be discussed.
Singapore has a unique and proactive approach towards managing the national transport system. This article explores the integrative approach of carsharing into the overall transport system from an individual sustainable mobility perspective. The authors argue that for Singapore, taxi services are the strongest competitor for the establishment of free-floating carsharing systems. Low taxi fares and a high distribution rate provide easy access for consumers and show great advantages in correspondence with the prevalent transport measures. Furthermore, the Singaporean government considers taxi services as part of public transport that helps bridging public transportation gaps in door-to-door travel. The article draws on literature review and expert interviews to evaluate the current market conditions and analyse the pros and cons of carsharing systems and taxi services as integrated part of the public transport system. The authors conclude by stating that from a sustainable perspective, the goal is to replace private car ownership. Provision of multi modal choices and therefore co-existence of different individual transport opportunities is indispensable.
Upon complexation to CuOTf, a PMe\(_3\)-stabilized bis(9-anthryl) diborene slowly undergoes an intramolecular hydroarylation reaction at room temperature. Subsequent triflation of the B–H bond with CuOTf, followed by a PMe\(_3\) transfer, finally yields a cyclic sp\(^2\)-sp\(^3\) boryl-substituted boronium triflate salt.
Despite the prevalence of stable π-complexes of most d\(^{10}\) metals, such as Cu(I) and Ni(0), with ethylene and other olefins, complexation of d\(^{10}\) Zn(II) to simple olefins is too weak to form isolable complexes due to the metal ion's limited capacity for π-backdonation. By employing more strongly donating π- ligands, namely neutral diborenes with a high-lying π(B=B) or- bital, monomeric 16-electron M(II)-diborene (M = Zn, Cd) π- complexes were synthesized in good yields. Metal–B2 π- interactions in both the solid and solution state were confirmed by single-crystal X-ray analyses and their solution NMR and UV-vis absorption spectroscopy, respectively. The M(II) centers adopt a trigonal planar geometry and interact almost symmetrically with both boron atoms. The MB2 planes significantly twist out of the MX\(_2\) planes about the M-centroid(B–B) vector, with angles rang- ing from 47.0° to 85.5°, depending on the steric interactions be- tween the diborene ligand and the MX\(_2\) fragment.