Refine
Has Fulltext
- yes (335)
Is part of the Bibliography
- yes (335)
Year of publication
Document Type
- Journal article (310)
- Doctoral Thesis (23)
- Conference Proceeding (2)
Language
- English (335) (remove)
Keywords
- chronic kidney disease (16)
- adrenocortical carcinoma (14)
- heart failure (14)
- Fabry disease (13)
- inflammation (11)
- mortality (11)
- myocardial infarction (11)
- echocardiography (10)
- hemodialysis (10)
- biomarker (8)
Author
- Fassnacht, Martin (62)
- Wanner, Christoph (54)
- Störk, Stefan (45)
- Ertl, Georg (31)
- Frantz, Stefan (26)
- Nordbeck, Peter (26)
- Sbiera, Silviu (24)
- Kroiss, Matthias (23)
- Altieri, Barbara (21)
- Morbach, Caroline (17)
- Weidemann, Frank (16)
- Liu, Dan (15)
- Drechsler, Christiane (14)
- Ronchi, Cristina L. (14)
- Heuschmann, Peter U. (13)
- Hu, Kai (13)
- Allolio, Bruno (12)
- Bauer, Wolfgang R. (12)
- Wagner, Martin (12)
- Frey, Anna (10)
- Gelbrich, Götz (10)
- Gerull, Brenda (10)
- Higuchi, Takahiro (10)
- Lapa, Constantin (10)
- Beuschlein, Felix (9)
- Deutschbein, Timo (9)
- Dischinger, Ulrich (9)
- Haring, Bernhard (9)
- Kircher, Stefan (9)
- Quinkler, Marcus (9)
- Reiter, Theresa (9)
- Ritter, Oliver (9)
- Weigand, Isabel (9)
- Werner, Rudolf A. (9)
- Fette, Georg (8)
- Hahner, Stefanie (8)
- Krane, Vera (8)
- Sbiera, Iuliu (8)
- Angermann, Christiane E. (7)
- Bauer, Wolfgang Rudolf (7)
- Buck, Andreas K. (7)
- Herold, Volker (7)
- Hofmann, Ulrich (7)
- Krieter, Detlef H. (7)
- Rücker, Viktoria (7)
- Schirbel, Andreas (7)
- Schneider, Reinhard (7)
- Beer, Meinrad (6)
- Güder, Gülmisal (6)
- Jakob, Peter Michael (6)
- Kurlbaum, Max (6)
- Lemke, Horst-Dieter (6)
- Pelzer, Theo (6)
- Schlegel, Nicolas (6)
- Terzolo, Massimo (6)
- Weismann, Dirk (6)
- Wiegering, Armin (6)
- Winter, Patrick (6)
- Bijnens, Bart (5)
- Brodehl, Andreas (5)
- Canu, Letizia (5)
- Colao, Annamaria (5)
- Gassenmaier, Tobias (5)
- Gensler, Daniel (5)
- Germer, Christoph-Thomas (5)
- Heidland, August (5)
- Herrmann, Sebastian (5)
- Jakob, Peter M. (5)
- Kampf, Thomas (5)
- Klinker, Hartwig (5)
- Kronenberg, Florian (5)
- Meybohm, Patrick (5)
- Oder, Daniel (5)
- Oezkur, Mehmet (5)
- Pilz, Stefan (5)
- Reibetanz, Joachim (5)
- Reincke, Martin (5)
- Sahiti, Floran (5)
- Schneider, Andreas (5)
- Seyfried, Florian (5)
- Sommer, Claudia (5)
- Traub, Jan (5)
- Warnock, David G. (5)
- Wassertheil-Smoller, Sylvia (5)
- Wild, Vanessa (5)
- Andelovic, Kristina (4)
- Arias-Loza, Paula (4)
- Detomas, Mario (4)
- Einsele, Hermann (4)
- Eisenhofer, Graeme (4)
- Ertl, Maximilian (4)
- Faggiano, Antongiulio (4)
- Jahns, Roland (4)
- Javadi, Mehrbod S. (4)
- Kleinschnitz, Christoph (4)
- Klopocki, Eva (4)
- Krämer, Johannes (4)
- Landwehr, Laura-Sophie (4)
- Lorenz, Kristina (4)
- Maack, Christoph (4)
- Megerle, Felix (4)
- Modica, Roberta (4)
- März, Winfried (4)
- Müntze, Jonas (4)
- Otto, Christoph (4)
- Ritz, Eberhard (4)
- Robledo, Mercedes (4)
- Rosenwald, Andreas (4)
- Rowe, Steven P. (4)
- Rüth, Marieke (4)
- Scherf-Clavel, Oliver (4)
- Serfling, Sebastian E. (4)
- Stoll, Guido (4)
- Tiffe, Theresa (4)
- Voelker, Wolfram (4)
- Wachter, Rolf (4)
- Wactawski-Wende, Jean (4)
- Wanner, C. (4)
- Wiegering, Verena (4)
- Zernecke, Alma (4)
- Üçeyler, Nurcan (4)
- Adamski, Jerzy (3)
- Albert, Judith (3)
- Arlt, Wiebke (3)
- Baudin, Eric (3)
- Bayer, Barbara (3)
- Berruti, Alfredo (3)
- Buck, Andreas (3)
- Ceccato, Filippo (3)
- Eckardt, Kai-Uwe (3)
- Edelmann, Frank (3)
- Eichner, Felizitas A. (3)
- Ergün, Süleyman (3)
- Ertl, G. (3)
- Flemming, Sven (3)
- Fuss, Carmina Teresa (3)
- Gaudron, Philipp Daniel (3)
- Germain, Dominique P. (3)
- Gram, Maximilian (3)
- Gunreben, Ignaz (3)
- Hasinger, Julia (3)
- Heckel, Tobias (3)
- Herrmann, Johannes (3)
- Herrmann-Lingen, Christoph (3)
- Herterich, Sabine (3)
- Heuschmann, Peter (3)
- Heuschmann, Peter U (3)
- Isberner, Nora (3)
- Kaspar, Mathias (3)
- Kerwagen, Fabian (3)
- Kotseva, Kornelia (3)
- Kraft, Peter (3)
- Kranke, Peter (3)
- Kredel, Markus (3)
- Kreissl, Michael C. (3)
- Köttgen, Anna (3)
- Lau, Kolja (3)
- Lotz, Christopher (3)
- Malsch, Carolin (3)
- Maniuc, Octavian (3)
- Mannelli, Massimo (3)
- Marzocco, Stefania (3)
- Nieswandt, Bernhard (3)
- Notz, Quirin (3)
- Ortiz, Alberto (3)
- Pachel, Christina (3)
- Prejbisz, Aleksander (3)
- Puppe, Frank (3)
- Reichardt, Holger M. (3)
- Riedmeier, Maria (3)
- Riester, Anna (3)
- Roewer, Norbert (3)
- Rost, Simone (3)
- Salinger, Tim (3)
- Scharnagl, Hubert (3)
- Scherer, Martin (3)
- Schlesinger, Tobias (3)
- Schuh, Kai (3)
- Störk, S. (3)
- Thomas, Phillip (3)
- Wakabayashi, Hiroshi (3)
- Werner, Rudolf (3)
- Williams, Tatjana (3)
- Wood, David (3)
- Wunder, Christian (3)
- Wyler von Ballmoos, Moritz (3)
- Zimmermann, Sebastian (3)
- Adam, Pia (2)
- Agarwal, Rajiv (2)
- Aghai-Trommeschlaeger, Fatemeh (2)
- Allelein, Stephanie (2)
- Angermann, Christiane (2)
- Arad, Michael (2)
- Arias-Loza, Paula Anahi (2)
- Arosio, Maura (2)
- Aulmann, Christoph (2)
- Baar, Wolfgang (2)
- Baba, Hideo A. (2)
- Bala, Margarita (2)
- Banas, Bernhard (2)
- Bathon, Kerstin (2)
- Beer, M. (2)
- Beierle, Felix (2)
- Berchialla, Paola (2)
- Berg, Elke (2)
- Beyer, Melanie (2)
- Beyth, Rebecca (2)
- Bidlingmaier, Martin (2)
- Bischler, Thorsten (2)
- Blankestijn, Peter J. (2)
- Blouin, Katja (2)
- Blozik, Eva (2)
- Boivin-Jahns, Valérie (2)
- Bots, Michiel L. (2)
- Bramlage, Peter (2)
- Brand, Eva (2)
- Brenner, Susanne (2)
- Breunig, Frank (2)
- Breunig, Margret (2)
- Broedl, Uli C. (2)
- Bundschuh, Ralph A. (2)
- Busch, Martin (2)
- Böhm, Michael (2)
- Calabrese, Anna (2)
- Calebiro, Davide (2)
- Cebulla, Mario (2)
- Cejka, Vladimir (2)
- Chen, Alon (2)
- Chen, Xinyu (2)
- Chertow, Glenn M. (2)
- Chifu, Irina (2)
- Chortis, Vasileios (2)
- Christ-Crain, Mirjam (2)
- Cikes, Maja (2)
- Cirnu, Alexandra (2)
- Coresh, Josef (2)
- Dandekar, Thomas (2)
- Davenport, Andrew (2)
- Davies, Eleanor (2)
- Decarolis, Boris (2)
- Deinum, Jaap (2)
- Delgobo, Murilo (2)
- Della Casa, Silvia (2)
- Dennedy, Michael C. (2)
- Devine, Eric (2)
- Dexneit, Thomas (2)
- Di Iorio, Biagio Raffaele (2)
- Donhauser, Julian (2)
- Dorsch, Oliver (2)
- Dralle, Henning (2)
- Düngen, Hans-Dirk (2)
- Eisele, Marion (2)
- Engel, Mareen (2)
- Erlic, Zoran (2)
- Fazeli, Gholamreza (2)
- Fenske, Wiebke Kristin (2)
- Fioretto, Paola (2)
- Fischer, Stefan (2)
- Frantz, S. (2)
- Germer, Christoph Thomas (2)
- Gesierich, Anja (2)
- Gimenez-Roqueplo, Anne-Paule (2)
- Gorski, Mathias (2)
- Goveas, Joseph S. (2)
- Grooteman, Muriel P.C. (2)
- Gummert, Jan (2)
- Gutjahr, Fabian Tobias (2)
- Hagen, Rudolf (2)
- Hammer, Fabian (2)
- Hankir, Mohamed (2)
- Hankir, Mohammed K. (2)
- Hantel, Constanze (2)
- Harenberg, Job (2)
- Hartmann, Sonja (2)
- Hartrampf, Philipp E. (2)
- Haun, Margot (2)
- Hayakawa, Nobuyuki (2)
- Heid, Iris M. (2)
- Heinze, Britta (2)
- Held, Christopher (2)
- Held, Matthias (2)
- Hendricks, Anne (2)
- Herrmann, Ken (2)
- Heuschmann, Peter Ulrich (2)
- Hoes, Arno W. (2)
- Hommers, Leif (2)
- Hughes, Derralynn A. (2)
- Hänscheid, Heribert (2)
- Härtel, Christoph (2)
- Hübner, Silvia (2)
- Jackson, Rebecca D. (2)
- Jager, Kitty J. (2)
- Januszewicz, Andrzej (2)
- Janz, Anna (2)
- Johanssen, Sarah (2)
- Johnson, Karen C. (2)
- Jovanovic, Ana (2)
- Karmann, Wolfgang (2)
- Ketteler, Markus (2)
- Kickuth, Ralph (2)
- Kienitz, Tina (2)
- Kimpel, Otilia (2)
- Kircher, Malte (2)
- Knop, Stefan (2)
- Knösel, Thomas (2)
- Koehler, Viktoria Florentine (2)
- Kohlhaas, Michael (2)
- Kollerits, Barbara (2)
- Kramer, Daniela (2)
- Kraus, Luitgard (2)
- Kraus, Sabrina (2)
- Krefting, Dagmar (2)
- Kroiß, Matthias (2)
- Krämer, Bernhard K. (2)
- Kuller, Lewis H. (2)
- Kunz, Meik (2)
- Königsrainer, Malina (2)
- Köping, Maria (2)
- Köstler, Herbert (2)
- Ladd, Mark E. (2)
- Lang, Isabell (2)
- Langer, Simon (2)
- Langton, Katharina (2)
- Leich, Ellen (2)
- Leng, Xiaoyan (2)
- Lengenfelder, Björn Daniel (2)
- Lenschow, Christina (2)
- Lenz, Kerstin (2)
- Lenzini, Livia (2)
- Lesch, Klaus-Peter (2)
- Levin, Adeera (2)
- Leyh, Rainer (2)
- Leyh, Rainer G. (2)
- Li, Man (2)
- Linhart, Aleš (2)
- Lohr, David (2)
- Lopau, Kai (2)
- Luconi, Michaela (2)
- Macdougall, Iain C. (2)
- Maeder, Uwe (2)
- Magyar, Attila (2)
- Mai, Knut (2)
- Malzahn, Uwe (2)
- Mathes, Denise (2)
- Mauer, Michael (2)
- Meining, Alexander (2)
- Meinitzer, Andreas (2)
- Melzer, Nima (2)
- Meyer, Gesine (2)
- Michel, Kai D. (2)
- Milting, Hendrik (2)
- Mlynski, Robert (2)
- Mostovaya, Ira M. (2)
- Märkl, Bruno (2)
- Müller, Sophie (2)
- Müller-Scholden, Lara (2)
- Neumann, Till (2)
- Niemann, Markus (2)
- Nordbeck, P. (2)
- Nubé, Menso J. (2)
- Nölting, Svenja (2)
- Oberberger, Johannes (2)
- Oeckl, Patrick (2)
- Oliveira, João P. (2)
- Opocher, Giuseppe (2)
- Otto, Markus (2)
- Pamporaki, Christina (2)
- Papotti, Mauro (2)
- Pecori, Alessio (2)
- Perkovic, Vlado (2)
- Petri, Nils (2)
- Petritsch, Bernhard (2)
- Pham, Mirko (2)
- Politei, Juan (2)
- Pontecorvi, Alfredo (2)
- Popp, Sandy (2)
- Prehn, Cornelia (2)
- Pryss, Rüdiger (2)
- Puglisi, Soraya (2)
- Quick, Harald H. (2)
- Ramos, Gustavo Campos (2)
- Rapizzi, Elena (2)
- Reel, Smarti (2)
- Reichardt, Sybille D. (2)
- Remde, Hanna (2)
- Robinson, Jennifer (2)
- Rommel, Eberhard (2)
- Rutten, Frans H. (2)
- Sailer, Clara Odilia (2)
- Sauvant, Christoph (2)
- Scaroni, Carla (2)
- Schick, Martin Alexander (2)
- Schilling, Bastian (2)
- Schlegel, Paul-Gerhardt (2)
- Schlieper, Georg (2)
- Schlötelburg, Wiebke (2)
- Schmalzing, Marc (2)
- Schmid, Benedikt (2)
- Schmitt, Dominik (2)
- Schmitt-Böhrer, Angelika (2)
- Schmull, Sebastian (2)
- Schneider, Markus P. (2)
- Schnyder, Ingeborg (2)
- Scholz, Nina (2)
- Schott, Matthias (2)
- Schreiber, Laura Maria (2)
- Schreiner, Jochen (2)
- Schultheiss, Ulla T. (2)
- Sell, Roxane (2)
- Selvin, Elizabeth (2)
- Serra, Andreas L. (2)
- Shehata-Dieler, Wafaa (2)
- Sherif, Mohammad A. (2)
- Shinaji, Tetsuya (2)
- Sieder, Christian (2)
- Sommer, C. (2)
- Spahn, Martin (2)
- Spitzweg, Christine (2)
- Stahrenberg, Raoul (2)
- Stanasiuk, Caroline (2)
- Stefansson, Kari (2)
- Steinacker, Petra (2)
- Steinhauer, Sonja (2)
- Stier, Christine (2)
- Tetti, Martina (2)
- Thorleifsson, Gudmar (2)
- Thorsteinsdottir, Unnur (2)
- Timmers, Henri J. L. M. (2)
- Tomaschitz, Andreas (2)
- Toto, Robert D. (2)
- Uttinger, Konstantin L. (2)
- Vergho, Dorothee (2)
- Vetrivel, Sharmilee (2)
- Vogel, Ulrich (2)
- Vujkovac, Bojan (2)
- Völler, Heinz (2)
- Wajant, Harald (2)
- Waldek, Stephen (2)
- Weber, Martin S. (2)
- Wegscheider, Karl (2)
- Weich, Alexander (2)
- Weidemann, F. (2)
- Weiss, Ingo (2)
- Wollborn, Jakob (2)
- Wortmann, Sebastian (2)
- Wyler von Ballmoos, Moritz C. (2)
- Yurdadogan, Tino (2)
- Zennaro, Maria-Christina (2)
- Zhang, Ru (2)
- Zink, Miriam (2)
- Zinman, Bernard (2)
- de Roij van Zuijdewijn, Camiel L.M. (2)
- van den Brandt, Jens (2)
- Abboud, Hanna E. (1)
- Abdelfatah, Nelly (1)
- Abdin, Amr (1)
- Abeßer, Marco (1)
- Abiose, Ademola (1)
- Adam, Elisabeth Hannah (1)
- Adams, Sharon (1)
- Adesso, Simona (1)
- Adler, Sharon G. (1)
- Afentakis, Nikolaos (1)
- Aghai, Fatemeh (1)
- Ai, Jun (1)
- Akizawa, Tadao (1)
- Al Ghuzlan, Abir (1)
- Al-Rubeaan, Khalid (1)
- Alam, Ahsan (1)
- Alamar, Manuel Ferrer (1)
- Albertova, P. (1)
- Albertova, Petra (1)
- Albrecht, Christina (1)
- Albus, Christian (1)
- Aleksic, Ivan (1)
- Alexander, John H. (1)
- Ali, Mina (1)
- Ali, Nairveen (1)
- Alizai, Patrick H. (1)
- Allgaier, Johannes (1)
- Allignol, Arthur (1)
- Almeida, Madson Q. (1)
- Alsonso, Alvaro (1)
- Amann, Kerstin (1)
- Amar, Laurence (1)
- Amarenco, Pierre (1)
- Amoroso, Antonio (1)
- Amr, Ali (1)
- Andag, Reiner (1)
- Anderlini, Paolo (1)
- Anders, Fabian (1)
- Angelousi, Anna (1)
- Angermann, C. E. (1)
- Ankenbrand, Markus (1)
- Ankenbrand, Markus Johannes (1)
- Antin, Joseph H. (1)
- Appel, Lawrence J. (1)
- Appel, Marc (1)
- Appenzeller, Silke (1)
- Appetecchia, Marialuisa (1)
- Arbustini, Eloisa (1)
- Ardehali, Hossein (1)
- Arias, Manuel (1)
- Arias-Loza, Paula-Anahi (1)
- Arnold, R (1)
- Arns, Wolfgang (1)
- Arslan, Fatih (1)
- Arvat, Emanuela (1)
- Ascierto, Maria Libera (1)
- Ascierto, Paolo A (1)
- Ashby, Damien R. (1)
- Ashour, DiyaaElDin (1)
- Asif, Abdul R. (1)
- Assfalg, Volker (1)
- Assié, Guillaume (1)
- Assmann, Gerd (1)
- Audhya, Paul (1)
- Augustin, Anne Marie (1)
- Aul, C (1)
- Autore, Giuseppina (1)
- Aßmus, Birgit (1)
- Baanstra, David (1)
- Backhaus, Joy (1)
- Badenhoop, Klaus (1)
- Baerlocher, GM (1)
- Baggott, Lucy E. (1)
- Bahner, Udo (1)
- Baid-Agrawal, Seema (1)
- Bakris, George L. (1)
- Balakirouchenane, David (1)
- Ballerini, Paola (1)
- Balonov, Ilja (1)
- Bancos, Irina (1)
- Bandleon, Sandra (1)
- Bargou, Ralf C. (1)
- Barr, Craig Scott (1)
- Barrea, Luigi (1)
- Barter, Philip (1)
- Barthel, Andreas (1)
- Basile, Carlo (1)
- Basile, Vittoria (1)
- Baskin, Polina (1)
- Bauer, Britta (1)
- Bauer, Wolfgang (1)
- Bauersachs, Rupert (1)
- Baumeister, Harald (1)
- Baur, Johannes (1)
- Baurmann, H (1)
- Bavendiek, Udo (1)
- Bayliss, Susan (1)
- Bea, Jennifer W. (1)
- Bechmann, Nicole (1)
- Beck, Hanna (1)
- Beck-Peccoz, Paolo (1)
- Beckmann, Jacques S. (1)
- Bedognetti, Davide (1)
- Bedrose, Sara (1)
- Beelen, D (1)
- Behr, Volker C. (1)
- Beilhack, Andreas (1)
- Beitner-Johnson, Dana (1)
- Bekteshi, Michaela (1)
- Belke, Darrell D. (1)
- Bellavia, Diego (1)
- Ben Jehuda, Ronen (1)
- Benevento, Elio (1)
- Bening, Constanze (1)
- Bensing, Sophie (1)
- Benz, Peter M. (1)
- Berbner, Annette (1)
- Berdyshev, Sergey (1)
- Berger, Jeffrey S. (1)
- Berger, U (1)
- Berlakovich, Gabriela (1)
- Bernhardt, Alexandra (1)
- Bernt, Alexander (1)
- Bertagna, Xavier (1)
- Bertherat, Jerôme (1)
- Bertherat, Jérôme (1)
- Berthoux, Francois (1)
- Bertsch, Uta (1)
- Bertucci, François (1)
- Bescos, Cristina (1)
- Best, Lyle G. (1)
- Betteridge, John (1)
- Betterle, Corrado (1)
- Betz, Boris (1)
- Betz, Matthias Johannes (1)
- Beyersdorf, Niklas (1)
- Beyersmann, Jan (1)
- Bezerra-Neto, João Evangelista (1)
- Bețiu, Alina M. (1)
- Bhala, Neeraj (1)
- Bichet, Daniel G. (1)
- Bick, Alexander G. (1)
- Biehl, Michael (1)
- Biere-Rafi, Sara (1)
- Binah, Ofer (1)
- Bindl, Dominik (1)
- Bircher, Andreas J. (1)
- Birnbaum, Daniel (1)
- Blaimer, M. (1)
- Blaimer, Martin (1)
- Blanchard, Anne (1)
- Blanchet, Benoit (1)
- Blasco, María A. (1)
- Bley, T. A. (1)
- Bley, Thorsten (1)
- Bley, Thorsten A. (1)
- Bley, Thorsten Alexander (1)
- Bliziotis, Nikolaos G. (1)
- Blocka, Joanna (1)
- Blohm, Elisabeth (1)
- Bluemel, Christina (1)
- Bluhmki, Erich (1)
- Bläker, Hendrik (1)
- Blömer, Nadja (1)
- Blümel, Rabea (1)
- Bochud, Murielle (1)
- Bock, Andreas (1)
- Bocklitz, Thomas (1)
- Boczor, Sigrid (1)
- Bodem, Jochen (1)
- Boehm, Hartmut (1)
- Boelens, Jaap-Jan (1)
- Boes, Eva (1)
- Bohnert, Simone (1)
- Boland, Anne (1)
- Borggrefe, Martin (1)
- Bork, Nadja (1)
- Bormann, M (1)
- Bornstein, Stefan R. (1)
- Bothou, Christina (1)
- Bottiglieri, Filomena (1)
- Bourdeau, Isabelle (1)
- Bowden, Donald W. (1)
- Boytsov, Sergey (1)
- Bozkurt, Süleyman (1)
- Brachmann, Johannes (1)
- Brack, Alexander (1)
- Brand, Theresa (1)
- Brandenburg, Vincent (1)
- Brandenburg, Vincent M. (1)
- Braun, Attila (1)
- Braun, Fabian (1)
- Braun, Leah (1)
- Braun-Dullaeus, Ruediger Christian (1)
- Brede, Christian (1)
- Breithardt, Günter (1)
- Breuer, Felix (1)
- Breunig, F. (1)
- Breuning, Margret (1)
- Brignardello, Francesca (1)
- Brock, Robert W. (1)
- Broderick, Peter (1)
- Broeckx, Bart (1)
- Broekhuizen, Berna D. L. (1)
- Brondani, Vania Balderrama (1)
- Broyl, Annemiek (1)
- Bruckert, Eric (1)
- Bruder, Oliver (1)
- Brunecker, Peter (1)
- Bruno, Raphael Romano (1)
- Buchberger, Alexander (1)
- Bucher, Michael (1)
- Bunjes, D (1)
- Burd, Paul (1)
- Burek, Malgorzata (1)
- Burger-Stritt, Stephanie (1)
- Burkard, Natalie (1)
- Burlock, Allison (1)
- Burmester, Sandra (1)
- Burrello, Jacopo (1)
- Busbridge, Mark (1)
- Buturovic-Ponikvar, Jadranka (1)
- Bäuerlein, Carina A. (1)
- Böger, Carsten A. (1)
- Bönhof, Leoni (1)
- Börner, Kevin (1)
- Büsche, G (1)
- Caamaño, Encarnación Bouzas (1)
- Cabrera, Gustavo (1)
- Cairns, Tereza (1)
- Calatayud, María (1)
- Caleiras, Eduardo (1)
- Calsina, Bruna (1)
- Calzado Canale, Marco A. (1)
- Campiglia, Pietro (1)
- Campione, Severo (1)
- Campo, Chiara (1)
- Cannavale, Giuseppe (1)
- Cano, Isaac (1)
- Cantini, Giulia (1)
- Cao, Yong (1)
- Carbone, Laura (1)
- Carnahan, Ryan M. (1)
- Carsten A., Böger (1)
- Casanova-Molla, Jordi (1)
- Cascón, Alberto (1)
- Caskey, Fergus J. (1)
- Castanheira, Mariana (1)
- Cauley, Jane A (1)
- Cernevskis, Harijs (1)
- Chabre, Olivier (1)
- Chambo, José Luiz (1)
- Chapdelaine, Isabelle (1)
- Charchar, Helaine da Silva (1)
- Charrow, Joel (1)
- Chatterjee, Manik (1)
- Chen, Bowang (1)
- Chen, Mengjia (1)
- Chen, Menjia (1)
- Chen, Nan (1)
- Chen, Nanhai G (1)
- Chen, Yii-Der Ida (1)
- Chen, Yong-Xiang (1)
- Chen, Yuan-Liang (1)
- Cherradi, Nadia (1)
- Chin, Melanie (1)
- Choi, Murim (1)
- Chopra, Martin (1)
- Chow, Kelvin (1)
- Christensen, Morten Overby (1)
- Chubanov, Vladimir (1)
- Cleries, Montserrat (1)
- Coassin, Stefan (1)
- Cohrdes, Caroline (1)
- Cole, J. Alexander (1)
- Cole, Shelley A. (1)
- Collart, Frederic (1)
- Comeau, Mary E. (1)
- Concistrè, Antonio (1)
- Contel, Joan Carles (1)
- Cooper, Mark E. (1)
- Coras, Roland (1)
- Cordell, Heather J. (1)
- Corovic, Hamo (1)
- Corteville, Carolin (1)
- Corteville, Caroline (1)
- Costa de Freitas, Ricardo Miguel (1)
- Couper, David (1)
- Crandall, Carolyn J (1)
- Cristante, Justine (1)
- Csef, Herbert (1)
- Cuevas, Ada (1)
- Currás-Freixes, Maria (1)
- Curtis, Jeffrey M. (1)
- Cusi, Daniele (1)
- Czarnocka, Barbara (1)
- Dagres, Nikolaos (1)
- Dahlqvist, Per (1)
- Dal Piaz, Fabrizio (1)
- Dalmazi, Guido Di (1)
- Dathe, Henning (1)
- Davenport, Clare (1)
- Davies, Faith E. (1)
- Davignon, Jean (1)
- Dawood, Peter (1)
- De Filpo, Giuseppina (1)
- De Francia, Silvia (1)
- De Martino, Maria Cristina (1)
- De Meester, Johan (1)
- Debus, Jörg (1)
- Deckert, Jürgen (1)
- Dedkova, Elena N. (1)
- Deeg, H. Joachim (1)
- Deeks, Jonathan J (1)
- Dege, Tassilo (1)
- Dehghan, Abbas (1)
- Dekkers, Olaf M. (1)
- Dellanna, Frank (1)
- Demirbas, Senem (1)
- Denis, Josiane (1)
- Desai, Pinkal (1)
- Deserno, Lorenz (1)
- Deubner, Nikolas (1)
- Di Dato, Carla (1)
- Di Iorio, Biagio (1)
- Di Micco, Lucia (1)
- Di Pasquale, Giovanni (1)
- Di Sarno, Antonella (1)
- Diao, Catherine (1)
- Didié, Michael (1)
- Diefenbacher, Markus E. (1)
- Dienemann, Thomas (1)
- Dienesch, Charlotte (1)
- Dierks, Christine (1)
- Dierks, Johann (1)
- Dieterich, Christoph (1)
- Dietrich, Georg (1)
- Diez, José Maria Abad (1)
- Dijkgraaf, Marcel G. W. (1)
- Dikic, Ivan (1)
- Dimkovic, Nada (1)
- Dinnes, Jacqueline (1)
- Dittmar, Ronny (1)
- Divashuk, Mikhail (1)
- Divers, Jasmin (1)
- Djukanovic, Ljubica (1)
- Doghman-Bouguerra, Mabrouka (1)
- Don-Wauchope, Andrew (1)
- Dorn, Gerald W. (1)
- Dornberger, V. (1)
- Drapkina, Oxana (1)
- Drechler, Christiane (1)
- Dreher, Niklas (1)
- Dressel, Ralf (1)
- Dudek, Jan (1)
- Dueñas-Espín, Ivan (1)
- Duff, Henry J. (1)
- Dufour, Carlo (1)
- Duggirala, Ravi (1)
- Durand, Nelly (1)
- Durstewitz, Kathleen (1)
- Díaz, Joan Manuel (1)
- Díaz-Talavera, Alberto (1)
- Döhner, H (1)
- Dölken, Lars (1)
- Dörhöfer, Lena (1)
- Dörr, M. (1)
- Dörries, Luise (1)
- Düking, Peter (1)
- Düring, Markus (1)
- D’Aniello, Francesco (1)
- Eapen, Mary (1)
- Eaton, Charles (1)
- Ebersbach, Paul (1)
- Eckhardt, Carolin (1)
- Eckhardt, Frithjof (1)
- Eckhardt, Kai-Uwe (1)
- Eden, Matthias (1)
- Edenhofer, Frank (1)
- Eder, Petra (1)
- Eder-Negrin, Petra (1)
- Edinger, M (1)
- Edler, Johanna-Sophie (1)
- Eggestein, Annika (1)
- Eidizadeh, Abass (1)
- Eikema, Dirk-Jan (1)
- Eils, Jürgen (1)
- Einsele, Herman (1)
- Eiringhaus, Jörg (1)
- Eisen, Binyamin (1)
- Eissler, Christoph (1)
- Eitner, Frank (1)
- Ekwall, Olov (1)
- Elias, Johannes (1)
- Elliott, Perry M. (1)
- Elmér, Eskil (1)
- Elston, Robert C. (1)
- Emberson, Jonathan (1)
- Emmert, Andrea (1)
- Engel, Jasper (1)
- Engelbertz, Christiane (1)
- Engelke, Udo F. H. (1)
- Ercolino, Tonino (1)
- Eriksson, Gabriel Nordling (1)
- Fabian, M (1)
- Fadda, Guido (1)
- Fadel, Elie (1)
- Falge, C (1)
- Faller, Hermann (1)
- Falorni, Alberto (1)
- Farnier, Michel (1)
- Fauser, A (1)
- Favier, Marie (1)
- Favier, Remi (1)
- Feil, Robert (1)
- Feldman, Harold I. (1)
- Feldt-Rasmussen, Ulla (1)
- Fenske, Wiebke (1)
- Ferioli, Silvia (1)
- Ferrannini, Ele (1)
- Ferrante, Emanuele (1)
- Ferrara, Alfonso Massimiliano (1)
- Ferrari, Roberto (1)
- Fichna, Marta (1)
- Fiedler, Jan (1)
- Figueiredo, Bonald C. (1)
- Figueiredo, Mirna M. O. (1)
- Filopanti, Marcello (1)
- Filosso, Pier Luigi (1)
- Finetti, Pascal (1)
- Finne, Patrik (1)
- Fischer, Andreas (1)
- Fischer, Denise (1)
- Fischer, Henrike J. (1)
- Fischer, J Th (1)
- Fischer, Lutz (1)
- Fischer, Thomas H. (1)
- Fischer, Tobias (1)
- Fitchett, David (1)
- Fitzgerald, Anthony P (1)
- Fleck, Eckart (1)
- Fliedner, Stephanie M. J. (1)
- Floege, Jürgen (1)
- Florescu, Christiane (1)
- Folsom, Aaron R. (1)
- Fornara, Paolo (1)
- Fox, Caroline S. (1)
- Fragoso, Maria Candida Barisson Villares (1)
- Frank, Breunig (1)
- Frank, Derk (1)
- Frank-Raue, Karin (1)
- Freedman, Barry I. (1)
- Freier, Erik (1)
- Frey, A. (1)
- Frey, Kathrin R. (1)
- Frey, Norbert (1)
- Friedrich, Michael T. (1)
- Friedrich, N. (1)
- Fritzsche, Kurt (1)
- Frosch, Matthias (1)
- Fruchart, Jean-Charles (1)
- Fröhling, Stefan (1)
- Fuchs, Konrad F. (1)
- Fujii, Naohiko (1)
- Furth, Susan L. (1)
- Fuss, Carmina (1)
- Fuss, Carmina T. (1)
- Förster, Carola Y. (1)
- Försti, Asta (1)
- Gaal, Chiara Claudia (1)
- Gabel, Alexander (1)
- Gaertner, Anna (1)
- Gamer, M. (1)
- Gan, Earn H. (1)
- Ganser, A (1)
- Gao, Xiao-Hong (1)
- Garcia-Aymerich, Judith (1)
- Garneata, Liliana (1)
- Garnett, Lauren (1)
- Gartner, Florian C. (1)
- Gass, Margery L (1)
- Gassenmaier, T. (1)
- Gasser, Martin (1)
- Gaudron, Philipp D. (1)
- Gaßner, Birgit (1)
- Geier, Andreas (1)
- Geisler, T. (1)
- Geissinger, Eva (1)
- Geistert, Wolfgang (1)
- Gekle, Michael (1)
- Genest, Jacques (1)
- Genser, Bernd (1)
- George, Jyothis T. (1)
- Gerhardt, Louisa M. S. (1)
- Gerner, Bettina (1)
- Gernert, Michael (1)
- Geroula, Aikaterini (1)
- Gerss, Joachim (1)
- Gesualdo, Loreto (1)
- Gharavi, Ali G. (1)
- Gherghiceanu, Mihaela (1)
- Giavoli, Claudia (1)
- Gietzelt, Matthias (1)
- Gigante, Maddalena (1)
- Gil, Eduardo (1)
- Gilbert, Fabian (1)
- Gill-Schuster, Daniel (1)
- Ginsberg, Henry N. (1)
- Giuffrida, Dario (1)
- Gkaniatsas, Spyridon (1)
- Gladziwa, Ulrich (1)
- Glatter, Nina (1)
- Goebeler, M-E (1)
- Goebeler, Maria-Elisabeth (1)
- Goebeler, Matthias (1)
- Golan, Eliezer (1)
- Goldschmidt, Hartmut (1)
- Gomez-Cabrero, David (1)
- González Fernández, Raquel (1)
- González, Patricia (1)
- Gordon, Paul M. K. (1)
- Gorski, Armin (1)
- Goto, Shin (1)
- Gotru, Sanjeev K. (1)
- Gotschy, Alexander (1)
- Gottlieb, Eyal (1)
- Gotto Jr., Antonio M. (1)
- Govindaraj, Vijayakumar (1)
- Graf, Carolin (1)
- Graff, Misa (1)
- Gratwohl, A (1)
- Grebe, S. J. (1)
- Grebe, Sören Jendrik (1)
- Greger, Helmut (1)
- Gregory, Walter A. (1)
- Greiser, Andreas (1)
- Grigoleit, Götz Ulrich (1)
- Grinwis, Guy C. M. (1)
- Grondey, Katja (1)
- Gronroos, Noelle (1)
- Groop, Per-Henrik (1)
- Grue, Pernille (1)
- Grüner, Sabine (1)
- Guadalix, Sonsoles (1)
- Gudbjartsson, Daniel F. (1)
- Gudermann, Thomas (1)
- Guest, Peter (1)
- Guggino, Gianluca (1)
- Gullberg, Urban (1)
- Gultekin, Melis (1)
- Guo, Shuxia (1)
- Guo, Xiuqing (1)
- Guo, Yong-Ming (1)
- Gutiérrez Avila, Gonzalo (1)
- Gutjahr, Fabian T. (1)
- Gutjahr-Lengsfeld, Lena (1)
- Guyon, Laurent (1)
- Gärtner, Anna (1)
- Göpfert, Dennis (1)
- Günther, Katharina (1)
- Güntner, Stefan (1)
- Haaf, Michaela (1)
- Haak, Harm (1)
- Haak, Harm R. (1)
- Haak, Thomas (1)
- Haass, Markus (1)
- Habra, Mouhammed Amir (1)
- Haeusler, Karl Georg (1)
- Haferlach, C (1)
- Hahner, Stephanie (1)
- Halkes, Stijn (1)
- Hallek, Michael (1)
- Hallhuber, Matthias (1)
- Halvarsson, Britt-Marie (1)
- Hamesch, Karim (1)
- Hamm, Henning (1)
- Hammel, Clara (1)
- Hammer, F. (1)
- Hammer, Gary D. (1)
- Hanke, Monika (1)
- Hankir, Mohammed Khair (1)
- Hannawacker, Annette (1)
- Hansmann, Jan (1)
- Hanson, Robert L. (1)
- Hansson, Markus (1)
- Hantel, Stefan (1)
- Hapke, Nils (1)
- Happle, Christine (1)
- Hartleb, Annika (1)
- Hartmann, Katrin (1)
- Hartmann, Oliver (1)
- Hasenfuss, Gerd (1)
- Hasenfuß, Gerd (1)
- Hasford, J (1)
- Hau, Hans‐Michael (1)
- Haubitz, Imme (1)
- Haug, Fabian (1)
- Haug, Julian (1)
- Hauser, Ingeborg (1)
- Hauser, T. (1)
- Hauser, Tobias Gregor (1)
- Hayden, Kathleen (1)
- He, Xintong (1)
- Heaf, James (1)
- Hebert, Kyle (1)
- Heemann, Uwe (1)
- Hefner, Jochen (1)
- Hehlmann, R (1)
- Heidecker, Bettina (1)
- Heidenreich, Julius (1)
- Heidenreich, Julius F. (1)
- Heimpel, H (1)
- Hein, Grit (1)
- Heinrichs, Margarete (1)
- Heiss, Gerardo (1)
- Heitzmann, Wolfram (1)
- Hellenkamp, Kristian (1)
- Heller, Katharina (1)
- Hellmann, A (1)
- Helluy, Xavier (1)
- Helmer, Philipp (1)
- Hemmelgarn, Brenda R. (1)
- Hemminki, Kari (1)
- Hendig, Doris (1)
- Henneges, Carsten (1)
- Henniger, Dorothea (1)
- Henrion, Marc (1)
- Hensel, Irina (1)
- Henzel, Katharina (1)
- Heppt, Markus V. (1)
- Herdeg, C. (1)
- Hering, Ilona (1)
- Hermans, Michael P. (1)
- Herold, Joerg (1)
- Herrero-Calvo, Jose Antonio (1)
- Herrmann, M. J. (1)
- Herrmann, S. (1)
- Hertenstein, B (1)
- Herting, Jonas (1)
- Herz, Stefan (1)
- Herzog, Gloria (1)
- Hescot, Ségolène (1)
- Heterich, Sabine (1)
- Heuschmann, P. U. (1)
- Hilge, Robert (1)
- Hillengass, Jens (1)
- Hiller, Karl-Heinz (1)
- Hillermann, Nele (1)
- Hindricks, Gerd (1)
- Ho, AD (1)
- Hochhaus, A (1)
- Hock, Michael (1)
- Hoff, Ana O. (1)
- Hoffmann, Annett (1)
- Hoffmann, Michael M. (1)
- Hoffmann, Michael Marcus (1)
- Hoffmann, Per (1)
- Hoffmann, Ulrich (1)
- Hoffmeister, Sabine (1)
- Hofman, Albert (1)
- Hofmann, Franz (1)
- Hofmann, Reiner (1)
- Hofmann, U. (1)
- Hofmann, Urlich (1)
- Hoitsma, Andries (1)
- Holfelder, Marc (1)
- Hollak, Carla E. M. (1)
- Homola, György (1)
- Homola, György A. (1)
- Homolya, István (1)
- Honegger, Jürgen Bernd (1)
- Hoos, Jennifer D. E. (1)
- Hopkin, Robert J. (1)
- Hoppe, Kerstin (1)
- Horn, Anne (1)
- Horn, M. (1)
- Hossfeld, DK (1)
- Hoster, Eva (1)
- Hou, Ping (1)
- Houlston, Richard S. (1)
- Howard, Barbara V. (1)
- Hoy, Wendy E. (1)
- Hoyer, Joachim (1)
- Hu, Dayi (1)
- Huang, Chunmei (1)
- Huang, Huateng (1)
- Huang, Paul L. (1)
- Huang, Shi-Bo (1)
- Hughes, Beverly A. (1)
- Hughes, Derralynn (1)
- Hulting, Anna-Lena (1)
- Hundt, Jennifer Elisabeth (1)
- Husebye, Eystein (1)
- Husebye, Eystein S. (1)
- Husseini, Leila (1)
- Hwang, Shih-Jen (1)
- Hâncu, Iasmina M. (1)
- Härtig, Wolfgang (1)
- Höhn, Anna (1)
- Hörnlein, Alexander (1)
- Höybye, Charlotte (1)
- Hübner, Sinah (1)
- Hübschmann, Daniel (1)
- Hüser, Norbert (1)
- Igaz, Peter (1)
- Igo, Jr, Robert P. (1)
- Ince, Hüseyin (1)
- Inzucchi, Silvio E. (1)
- Ipp, Eli (1)
- Iyengar, Sudha K. (1)
- Izzi, Claudia (1)
- Jablonka, Alexandra (1)
- Jackson, Graham H. (1)
- Jacobs, Graeme B. (1)
- Jahns, Valerie (1)
- Jakob, P. M. (1)
- Janaki-Raman, Sudha (1)
- Jankovski, Joachim (1)
- Jansen, Jeroen J. (1)
- Jarausch, Johannes (1)
- Jardine, Alan G. (1)
- Jeevaratnam, Praveen (1)
- Jefferies, John L. (1)
- Jefferson, Emily (1)
- Jefferson, Emily R. (1)
- Jendretzki, Julia (1)
- Jeyaseelan, Jarline (1)
- Jiang, Hai-Shen (1)
- Jiang, Linmiao (1)
- Jiménez-Villa, Scherezade (1)
- Johansen, Odd Erik (1)
- John, Dennis (1)
- Johnson, David C. (1)
- Johnson, Karen C (1)
- Johnsson, Ellinor (1)
- Joniau, Steven (1)
- Jordan, Jochen (1)
- Jordán Garrote, Ana-Laura (1)
- Juchem, Christoph (1)
- Julian, Bruce A. (1)
- Jung, Pius (1)
- Jungmann, Andreas (1)
- Jurowich, Christian (1)
- Jöud, Magnus (1)
- Jünger, Jana (1)
- Jürgensmeyer, Sabine (1)
- Kadowaki, Takashi (1)
- Kafke, Waldemar (1)
- Kahles, Heinrich (1)
- Kahn, Ann-Kathrin (1)
- Kaiser, Martin (1)
- Kalluvya, Samuel (1)
- Kalogirou, Charis (1)
- Kamensky, Victor (1)
- Kampe, Olle (1)
- Kamphuisen, Pieter (1)
- Kantaria, Nino (1)
- Kao, W. H. Linda (1)
- Kao, W.H. (1)
- Kapoor, Neena (1)
- Karmann, W. (1)
- Karnib, Hussein H. (1)
- Kasang, Christa (1)
- Kasiske, Bertram L. (1)
- Kasperlik-Zaluska, Anna (1)
- Kastelan, Darko (1)
- Katsarava, Zaza (1)
- Katus, Hugo A. (1)
- Katz, Amos (1)
- Katz, Sylvia (1)
- Kaufmann, Ralf (1)
- Kaye, Rachelle (1)
- Kebis, Anton (1)
- Keenoy, Esteban de Manuel (1)
- Kehlenbrink, Sylvia (1)
- Keil, Ulrich (1)
- Keller, Benjamin J. (1)
- Kelm, Matthias (1)
- Kempthorne-Rawson, Joan (1)
- Kendl, Sabine (1)
- Kerkau, Thomas (1)
- Kerscher, Alexander G. (1)
- Kerwagen, Simon (1)
- Kestler, Hans A. (1)
- Kesztyüs, Tibor (1)
- Kielstein, Jan T. (1)
- Kilian, Teresa (1)
- Kim, Baek (1)
- Kimmel, Paul L. (1)
- Kindermann, Aljoscha (1)
- Kindermann, Ingrid (1)
- Kindler, T (1)
- Kirchhof, Jan (1)
- Kirchhof, Paulus (1)
- Kirschmer, Nadine (1)
- Kiryluk, Krzysztof (1)
- Kiseleva, Anna (1)
- Kistler, Andreas D. (1)
- Kiwitz, Tobias (1)
- Klag, Michael J. (1)
- Klaiber, Michael (1)
- Klauke, Bärbel (1)
- Kleinert, Evelyn (1)
- Klenovics, Kristina Simon (1)
- Kliem, Volker (1)
- Klingel, Karin (1)
- Klocke, B. (1)
- Kluijtmans, Leo A. J. (1)
- Kluter, Elisabeth J. (1)
- Klügl, Peter (1)
- Kneitz, Burkhard (1)
- Knol, Cora (1)
- Knop, Juna-Lisa (1)
- Knops, Noël (1)
- Knowler, William C. (1)
- Koch, Alexander (1)
- Kockum, Ingrid (1)
- Kocot, Arkadius (1)
- Kodama, Tatsuhiko (1)
- Kohn, Orly F. (1)
- Kolb, H-J (1)
- Kolb-Mäurer, Annette (1)
- Kolesnyk, Mykola (1)
- Kolleritz, Barbara (1)
- Kollikowski, Anne (1)
- Kollmannsberger, Philip (1)
- Kolokotronis, Konstantinos (1)
- Komechen, Heloisa (1)
- Kongola, Gilbert (1)
- Kooperberg, Charles (1)
- Koos, Ralf (1)
- Korb, Doreen (1)
- Kordsmeyer, Maren (1)
- Koretskiy, Sergey (1)
- Koschker, Ann-Cathrin (1)
- Koschker, Ann-Kathrin (1)
- Kosmala, Aleksander (1)
- Kosnopfel, Corinna (1)
- Kotseva, K. (1)
- Koutsilieri, Eleni (1)
- Kramann, Rafael (1)
- Kramar, Reinhard (1)
- Kramer, Anneke (1)
- Kramer, Bastian (1)
- Krane, V. (1)
- Krapp, J. (1)
- Krauth, Melissa (1)
- Krebs, Jonathan (1)
- Krebs, Markus (1)
- Kreft, Sophia (1)
- Kreissl, Michael (1)
- Krempf, Michel (1)
- Kress, Tobias (1)
- Kretzler, Matthias (1)
- Krietenstein, Laura (1)
- Kristiansson, Kati (1)
- Kristinsson, Sigurdur Y. (1)
- Kroger, Nicolaus (1)
- Kroh, Andreas (1)
- Krone, Manuel (1)
- Krone, Nils (1)
- Krop, Philipp (1)
- Kropf, Saskia (1)
- Krueger, Thilo (1)
- Kröger, N (1)
- Kucharska-Newton, Anna (1)
- Kudryavtseva, Maria (1)
- Kuhlen, Michaela (1)
- Kuhlencordt, Peter J. (1)
- Kuhn, Bernhard (1)
- Kuhn, Michaela (1)
- Kuiper, Rowan (1)
- Kulikova, Olga (1)
- Kunstmann, Erdmute (1)
- Kunz, A. S. (1)
- Kunz, Andreas (1)
- Kunz, Andreas S. (1)
- Kunzmann, Volker (1)
- Kurtz, Caroline (1)
- Kurzai, Oliver (1)
- Kuse, R (1)
- Kutalik, Zoltán (1)
- Kuypers, Dirk (1)
- Käs, J. (1)
- Köhler, Friedrich (1)
- Köllner, Volker (1)
- König, Paul (1)
- König, Sarah (1)
- Köstler, H. (1)
- Kübler, Hubert (1)
- Kügler, Sebastian (1)
- Kühler, Leif (1)
- La Salvia, Anna (1)
- LaMonte, Michael J. (1)
- Lachin, John M. (1)
- Lacombe, Amanda Meneses Ferreira (1)
- Lacroix, André (1)
- Ladwig, Karl-Heinz (1)
- Laffan, Michael A. (1)
- Lahr, Maarten M. H. (1)
- Lalli, Enzo (1)
- Lambers Heerspink, Hiddo J. (1)
- Lambert, Michele P. (1)
- Lammers, Jan Willem (1)
- Lammers, Jan-Willem J. (1)
- Lammert, Alexander (1)
- Lamprecht, Anna-Karina (1)
- Landmesser, Ulf (1)
- Lang, Katharina (1)
- Langefeld, Carl D. (1)
- Langer, Christian (1)
- Langer, Peter (1)
- Langeveld, Mirjam (1)
- Langguth, Berthold (1)
- Langsenlehner, Tanja (1)
- Lania, Andrea Gerardo (1)
- Larsen, Casper K. (1)
- Lascu, Ana (1)
- Laser, Kai Thorsten (1)
- Lassalle, Mathilde (1)
- Latoschik, Marc E. (1)
- Leak, Tennille S. (1)
- Leandro-García, Luis J. (1)
- Lederbogen, Florian (1)
- Leehey, David J. (1)
- Leha, Andreas (1)
- Lehmann, Marc (1)
- Lei, Guang-Hua (1)
- Leivestad, Torbjørn (1)
- Lemay, Roberta (1)
- Lenders, Jacques W. M. (1)
- Lenders, Malte (1)
- Lengenfelder, Björn (1)
- Lenhoff, Stig (1)
- Lenive, Oleg (1)
- Lenz, Christof (1)
- Leppich, Robert (1)
- Leskien, Miriam (1)
- Letizia, Claudio (1)
- Letón, Rocío (1)
- Leutritz, Tobias (1)
- Leyh, R. (1)
- Leyh, Rainer G (1)
- Leyva, Francisco (1)
- Lezius, Susanne (1)
- Li, Guo (1)
- Li, Ni (1)
- Li, Wenjun (1)
- Li, Xiao (1)
- Li, Yu-Jin (1)
- Li, Zong-Sheng (1)
- Libè, Rossella (1)
- Libé, Rossella (1)
- Liccardi, Alessia (1)
- Liedtke, Daniel (1)
- Lifton, Richard P. (1)
- Liman, Leon (1)
- Lincke, Thomas (1)
- Lindemann, HW (1)
- Lindner, Thomas (1)
- Linthorst, Gabor E. (1)
- Lippert, Juliane (1)
- Liu, D. (1)
- Liu, Jungmin (1)
- Liu, Simin (1)
- Lluch-Ariet, Magí (1)
- Lobell, Anna (1)
- Locatelli, Francesco (1)
- Lock, Johan Friso (1)
- Lohse, Christian (1)
- Lohse, Martin J. (1)
- Loli, Paola (1)
- Lopot, Frantisek (1)
- Lorenz, Kerstin (1)
- Lorenz, Lora (1)
- Lorenzen, Johan (1)
- Losa, Marco (1)
- Ludwig, T. (1)
- Luxenhofer, Robert (1)
- Lâm, Thiên-Trí (1)
- Lévesque, Renée (1)
- Löffler, Claudia (1)
- Löhr, Mario (1)
- Lückerath, Katharina (1)
- Lüers, Claus (1)
- Ma, Li (1)
- Macarthur, Katie D. R. (1)
- Maccario, Mauro (1)
- Machann, Wolfram (1)
- Mackenrodt, Daniel (1)
- Macário, Fernando (1)
- Magaz, Angela (1)
- Mages, Bianca (1)
- Mages, Christine (1)
- Maggi, Mario (1)
- Magliocca, Giorgia (1)
- Magnusson, Patrik K. (1)
- Magyar, Atilla (1)
- Maiellaro, Isabella (1)
- Maier, Sebastian (1)
- Maisch, Bernhard (1)
- Maixnerova, Dita (1)
- Majinge, Charles (1)
- Malchiodi, Elena (1)
- Malhotra, Alka (1)
- Malinowski, Klaus (1)
- Malzahn, U. (1)
- Mambretti, Egle M. (1)
- Manson, JoAnn E. (1)
- Mantero, Franco (1)
- Mantovani, Giovanna (1)
- Marciello, Francesca (1)
- Mariani, Beatriz Marinho de Paula (1)
- Marincola, Francesco M (1)
- Marquardt, André (1)
- Marschollek, Michael (1)
- Marsh, Judith C. W. (1)
- Martens, Kristina (1)
- Martini, Chiara (1)
- Martins, Anna Maria (1)
- Martín-Escobar, Eduardo (1)
- Martínez, Paula (1)
- Martínez-Montes, Ángel M. (1)
- Maruti, Sonia S. (1)
- Marx, Almuth (1)
- Marx, Nikolaus (1)
- Maródi, László (1)
- Matevossian, Edouard (1)
- Mathews, Vikram (1)
- Matsuo, Seiichi (1)
- Matsushita, Masayuki (1)
- Matsuzawa, Yuji (1)
- Mattenheimer, Katharina (1)
- Mattheus, Michaela (1)
- Mayer, Gert (1)
- Mayer, J (1)
- McDonald, Andrew (1)
- McGuire, Darren K. (1)
- McMurray, John (1)
- McMurray, John J. (1)
- Meder, Benjamin (1)
- Megías, Diego (1)
- Mehrhof, Felix (1)
- Meier, Friedegund (1)
- Meij, Björn P. (1)
- Meijer, Rudy (1)
- Mekies, Lucy N. (1)
- Mellid, Sara (1)
- Mellqvist, Ulf-Henrik (1)
- Mendonca, Berenice Bilharinho (1)
- Mercier, Olaf (1)
- Merke, Deborah P. (1)
- Merriman, Tony R. (1)
- Mershina, Elena (1)
- Merzweiler, Angela (1)
- Meshkov, Alexey (1)
- Messroghli, Daniel (1)
- Metcalfe, Wendy (1)
- Methven, Shona (1)
- Metzger, Marie (1)
- Metzner, Valentin (1)
- Meyer, Colin J. (1)
- Meyer, Cord B. (1)
- Meyer, Katie (1)
- Meyer, Thomas (1)
- Michalska, Marta (1)
- Migliorini, Gabriele (1)
- Mignani, Renzo (1)
- Mildner, Miriam (1)
- Milenkovic, Vladimir M. (1)
- Minotta, Roberto (1)
- Miranda-Laferte, Erick (1)
- Miras, Alexander D. (1)
- Mischak, Harald (1)
- Mitchell, Anna L. (1)
- Mitchell, Jonathan S. (1)
- Mittermeier, Lorenz (1)
- Mlewa, Mathias (1)
- Moharra, Montserrat (1)
- Monaco, Claudia (1)
- Mone, Pasquale (1)
- Monfil, Calos Calvo (1)
- Monoranu, Camelia-Maria (1)
- Monteagudo, María (1)
- Montellano, Felipe A. (1)
- Monterde, David (1)
- Montero-Conde, Cristina (1)
- Montes-Cobos, Elena (1)
- Mora, Joana (1)
- Morelli, Valentina (1)
- Morgan, Gareth J. (1)
- Mucha, Krzysztof (1)
- Muegge, Dirk (1)
- Muehlfeld, Anja (1)
- Muellenbach, Ralf Michael (1)
- Muellges, Wolfgang (1)
- Mufti, Ghulam J. (1)
- Mulansky, Lena (1)
- Mulatero, Paolo (1)
- Mullen, William (1)
- Muntean, Danina M. (1)
- Murad, M. Hassan (1)
- Muscogiuri, Giovanna (1)
- Mutlak, Haitham (1)
- Myasnikov, Roman (1)
- März, Juliane (1)
- Möller-Ehrlich, Kerstin (1)
- Möllmann, Dorothe (1)
- Mühlenbruch, Georg (1)
- Müller, Frank (1)
- Müller, MC (1)
- Müller, Oliver J. (1)
- Müller, Stefan P. (1)
- Müller-Höcker, Josef (1)
- Müllges, Wolfgang (1)
- Münch, Christian (1)
- Nadal, Jennifer (1)
- Nadalin, Silvio (1)
- Nadler, Walter (1)
- Nagai, Michiaki (1)
- Nagel, Eckhard (1)
- Nagel, Eike (1)
- Nagels, Klaus (1)
- Nagy, Judit (1)
- Nahi, Hareth (1)
- Nair, Viji (1)
- Nalin, Marco (1)
- Narita, Ichiei (1)
- Nasi-Kordhishti, Isabella (1)
- Natarajan, Pradeep (1)
- Nauck, M. (1)
- Negele, Thomas (1)
- Nelander, Sven (1)
- Nelson, Robert G. (1)
- Nerl, C (1)
- Nesi, Gabriella (1)
- Nessel, Lisa (1)
- Nettleton, Jennifer A. (1)
- Neuenroth, Lisa (1)
- Neuhaus, Winfried (1)
- Neuhauser, Hannelore (1)
- Neumann, Ulf P. (1)
- Newman, Jennifer (1)
- Neyer, Ulrich (1)
- Nguyen, Patricia K. (1)
- Nicholas, Susanne B. (1)
- Nickel, Alexander (1)
- Nickel, Jolanta (1)
- Niemann, M. (1)
- Nightingale, Peter (1)
- Nikolaev, Viacheslav O. (1)
- Nilsson, Björn (1)
- Nishi, Mirian Yumie (1)
- Nitschke, Martin (1)
- Noordzij, Marlies (1)
- Nordbeck, Arno (1)
- Nose, Naoko (1)
- Noutsias, M. (1)
- Novak, Jan (1)
- Noveanu, Lavinia (1)
- Novotny, Alexander (1)
- Novotny, J (1)
- Nowak, Albina (1)
- Nurden, Alan T. (1)
- Nurden, Paquita (1)
- Nygren, Anders (1)
- Nägele, Herbert (1)
- Nöthen, Markus M. (1)
- Núñez-Cortés, Jesús Millán (1)
- O'Seaghdha, Conall M. (1)
- Obermayer-Pietsch, Barbara (1)
- Oberwinkler, Heinz (1)
- Obrador, Gregorio T. (1)
- Ockene, Judith K. (1)
- Oelkers, Wolfgang (1)
- Ogawa, Hisao (1)
- Oliveira, João-Paulo (1)
- Ollier, William (1)
- Oo, Adrian (1)
- Oreglia, Maurine (1)
- Oritz, Alberto (1)
- Orlandi, Paula (1)
- Osswald, Andrea (1)
- Ostermeier, Eva (1)
- Other, Katharina (1)
- Oßwald, Andrea (1)
- O’Brien, Stephen J. (1)
- Paci, Angelo (1)
- Padmapriya, Ponnuswamy (1)
- Pahl, Madeleine V. (1)
- Pahor, Nikolett (1)
- Palkovits, Miklós (1)
- Palsson, Runolfur (1)
- Palta, Priya (1)
- Paluszkiewicz, Lech (1)
- Pankuweit, Sabine (1)
- Panzer, Ulf (1)
- Parasiliti-Caprino, Mirko (1)
- Parekh, Rulan S. (1)
- Parise, Ivy Zortéa S. (1)
- Parving, Hans-Henrik (1)
- Paschke, Ralf (1)
- Patel, Manesh R. (1)
- Paul, Katharina (1)
- Paul, Vincent (1)
- Paulweber, Bernhard (1)
- Pauws, Steffen (1)
- Pavlickova, Andrea (1)
- Pearce, Simon H. S. (1)
- Pechter, Ülle (1)
- Peitzsch, Mirko (1)
- Pellegrini, Bianca (1)
- Pellegrino, Micaela (1)
- Pelz, Jörg O. W. (1)
- Pelzer, Heinz-Theo (1)
- Pencina, Michael J. (1)
- Penna-Martinez, Marissa (1)
- Perge, Pal (1)
- Pergola, Pablo E. (1)
- Perola, Markus (1)
- Perotti, Paola (1)
- Peterson, Eefke (1)
- Petramala, Luigi (1)
- Petrescu, Lucian (1)
- Petritsch, B. (1)
- Petruski-Ivleva, Natalia (1)
- Pettinger, Mary (1)
- Pezzolesi, Marcus G. (1)
- Pfaffle, Antony E. (1)
- Pfarr, Egon (1)
- Pfirrmann, M (1)
- Pfreundschuh, M (1)
- Phipps-Green, Amanda (1)
- Pia, Anna (1)
- Pichl, Josef (1)
- Pidala, Joseph (1)
- Piera, Jordi (1)
- Pieske, Burkert (1)
- Pieske, Burkert M. (1)
- Pilus, Polina (1)
- Pippias, Maria (1)
- Pisarski, Przemyslaw (1)
- Pittaway, James (1)
- Pittaway, James F.H. (1)
- Pivonello, Claudia (1)
- Pivonello, Rosario (1)
- Pizarro, Carmen (1)
- Plassmeier, Lars (1)
- Platt, Hazel (1)
- Pluta, Natalie (1)
- Plutzky, Jorge (1)
- Pohl, Greta Marie (1)
- Polat, Bülent (1)
- Pollock, Carol A. (1)
- Polsky, Bruce (1)
- Pomper, Martin G. (1)
- Ponce, Elvira (1)
- Ponce, Sara (1)
- Ponnuswamy, Padmapriya (1)
- Pontoriero, Giuseppe (1)
- Porfiri, Emilio (1)
- Pos, Zoltan (1)
- Pospiech, Andreas (1)
- Post, Antonia (1)
- Potter, Victoria (1)
- Pour Hakimi, Seyed Ahmad (1)
- Powe, Neil (1)
- Praast, Christian (1)
- Prasser, Fabian (1)
- Preiser, Wolfgang (1)
- Preising, Christina (1)
- Prettin, Christiane (1)
- Prieto-Garcia, Cristian (1)
- Prince, Martin R. (1)
- Probst, Thomas (1)
- Proff, Jochen (1)
- Prondzinsky, R. (1)
- Prugger, Christof (1)
- Prümmer, O (1)
- Prütz, Karl G. (1)
- Pulgarín-Alfaro, Marta (1)
- Pulzer, Alina (1)
- Puszkiel, Alicja (1)
- Putter, Hein (1)
- Pérez-Martínez, Manuel (1)
- Quilitzsch, Anika (1)
- Rader, Daniel J. (1)
- Raff, Ulrike (1)
- Rafnar, Thorunn (1)
- Rahimi, Kazem (1)
- Rahmel, Axel (1)
- Rak, Kristen (1)
- Rakebrandt, Anja (1)
- Ramos, Gustavo (1)
- Ramsoebhag, Anne‐Marie (1)
- Rangrez, Ashraf Y. (1)
- Rapa, Shara Francesca (1)
- Rasooly, Rebekah S. (1)
- Ratkovic, Marina (1)
- Ratnavadivel, Sandra (1)
- Raue, Friedhelm (1)
- Razzore, Paola (1)
- Rebholz, Casey M. (1)
- Redlich, Antje (1)
- Reel, Parminder (1)
- Reel, Parminder S. (1)
- Refardt, Julie (1)
- Regev, Danielle (1)
- Regitz-Zagrosek, Vera (1)
- Regojo, Rita M. (1)
- Reichert, Manfred (1)
- Reichhart, Nadine (1)
- Reidenberg, Bruce E. (1)
- Reif, Andreas (1)
- Reimondo, Giuseppe (1)
- Reinboth, Jennifer (1)
- Reinecke, Holger (1)
- Reiner, Alexander P. (1)
- Reiners, Christoph (1)
- Reissland, Michaela (1)
- Reiter, A (1)
- Reiter, Therese (1)
- Remuzzi, Giuseppe (1)
- Renders, Lutz (1)
- Resić, Halima (1)
- Restifo, Nicholas P (1)
- Rethwilm, Axel (1)
- Rettig, Rainer (1)
- Reusch, Julia (1)
- Reuter, Miriam (1)
- Reyher, Christian (1)
- Rheinwalt, Karl P. (1)
- Rice, Carmel (1)
- Richter, Annette (1)
- Richter, Jendrik (1)
- Richter, Susan (1)
- Rickert, V. (1)
- Rickert, Vanessa (1)
- Riedl, Katharina A. (1)
- Riedmiller, Hubertus (1)
- Riemer, Uwe (1)
- Riese, Thorsten (1)
- Ritter, Christian O. (1)
- Ritz, Miriam (1)
- Ritzel, Katrin (1)
- Rivadeneira, Fernando (1)
- Rizk-Rabin, Marthe (1)
- Robertson, Michele (1)
- Robitzkat, Katharina (1)
- Roca, Josep (1)
- Roche-Lancaster, Oisin (1)
- Rodriguez, Marcela (1)
- Rodriguez-Perales, Sandra (1)
- Rodríguez-Antona, Cristina (1)
- Rogowski-Lehmann, Natalie (1)
- Rohanizadegan, Mersedeh (1)
- Rohr, Claudia (1)
- Rolfes, Caroline (1)
- Romanos, Marcel (1)
- Roncador, Giovanna (1)
- Ronchi, Christina Lucia (1)
- Rosenfeldt, Mathias (1)
- Rosenkranz, Alexander R. (1)
- Rosenkranz, Stephan (1)
- Rosenstock, Julio (1)
- Ross, Fiona M. (1)
- Rossano, Fabio (1)
- Rosselet, A (1)
- Rossi, Gian Paolo (1)
- Rost, Christian (1)
- Rost, S. (1)
- Rothe, Hansjörg (1)
- Rotimi, Charles N. (1)
- Rotter, Jerome I. (1)
- Rotzinger, Laura (1)
- Roychoudhuri, Rahul (1)
- Rubin, Beatrice (1)
- Rump, Lars‐Christian (1)
- Rutkowski, Boleslaw (1)
- Sachs, Alfred P. (1)
- Sack, Stefan (1)
- Sacks, Frank M. (1)
- Sadikot, Shaukat (1)
- Saeger, Wolfgang (1)
- Sahdev, Anju (1)
- Sala, Elisa (1)
- Salman Haider, Malik (1)
- Salvador, Ellaine (1)
- Salzmann, Steffen (1)
- Sanchez-Nino, Maria D. (1)
- Sandner, Benjamin (1)
- Sanna-Cherchi, Simone (1)
- Sanns, Andreas (1)
- Santaeugenia, Sebastià (1)
- Santos, Raul D. (1)
- Sasse, André (1)
- Saußele, S (1)
- Savastano, Silvia (1)
- Savoldi, Silvana (1)
- Sayehli, Cyrus (1)
- Sayer, HG (1)
- Schaaf, Alice (1)
- Schaap, Nicolaas P. (1)
- Schad, Lothar R. (1)
- Schadendorf, Dirk (1)
- Schaefer, Franz (1)
- Schaeffner, Elke S. (1)
- Schatz, M (1)
- Schedelbeck, Ulla (1)
- Scheffold, Thomas (1)
- Scheid, C (1)
- Scheller, Carsten (1)
- Schelling, Jeffrey R. (1)
- Schenk, M (1)
- Scherl, Alexander (1)
- Scheurlen, Michael (1)
- Schiavi, Francesca (1)
- Schich, Martin (1)
- Schick, Martin A. (1)
- Schickler, Marc (1)
- Schiffmann, Lisa (1)
- Schildhaus, Hans-Ulrich (1)
- Schindehütte, Magnus (1)
- Schindler, Paul (1)
- Schipper, Sandra (1)
- Schirmer, V. (1)
- Schlaffer, Sven (1)
- Schlee, Winfried (1)
- Schlereth, Florian (1)
- Schlesinger-Irsch, Ulrike (1)
- Schlimok, G (1)
- Schlosser, Andreas (1)
- Schmid, Jan-Stefan (1)
- Schmid, Matthias (1)
- Schmidt-Pennington, Laura (1)
- Schmidt-Wolf, I (1)
- Schmiedeke, Benjamin (1)
- Schmiedeke, Daniel (1)
- Schmitt, Angelika (1)
- Schmitt, Corinna (1)
- Schmitz, N (1)
- Schmitz, Sophia M. (1)
- Schneeberger, Stefan (1)
- Schneider, Dieter (1)
- Schneider, Petra (1)
- Schneider, Philipp (1)
- Schnittger, S (1)
- Schobel, Johannes (1)
- Scholz, Friederike (1)
- Schonenberg, Helen (1)
- Schrader, Nikolas (1)
- Schramm, Lothar (1)
- Schraven, Sebastian (1)
- Schraven, Sebastian P. (1)
- Schröter, Nils (1)
- Schröttle, Angelika (1)
- Schubert, Stephan (1)
- Schubert-Unkmeir, Alexandra (1)
- Schuhmann, Michael K. (1)
- Schuler, Irina (1)
- Schulz, Martin (1)
- Schulze, Almut (1)
- Schulze, Andres (1)
- Schulze, Harald (1)
- Schumacher, Martin (1)
- Schupp, Nicole (1)
- Schurgers, Leon (1)
- Schwacke, Harald (1)
- Schwenger, Vedat (1)
- Schwerdtfeger, R (1)
- Schwinn, Stefanie (1)
- Schäfer, E (1)
- Schäfer, Viktoria (1)
- Schöfl, Christof (1)
- Schönberger, Jost (1)
- Schönfeld, Stephan (1)
- Schülein-Völk, Christina (1)
- Scoazec, Jean-Yves (1)
- Scolari, Francesco (1)
- Scott-Wild, Vanessa (1)
- Sedor, John R. (1)
- Seethaler, Michael (1)
- Sehner, Susanne (1)
- Seidlmaier, Lea (1)
- Seidlmayer, Lea K. (1)
- Seldin, Michael F. (1)
- Selig, Katharina (1)
- Sester, Urban (1)
- Seydelmann, Nora (1)
- Seyfarth, Melchior (1)
- Seyfried, Florian Johannes David (1)
- Shackleton, Cedric H. L. (1)
- Shadyab, Aladdin H (1)
- Shah, Vallabh O. (1)
- Shapiro, Igor (1)
- Sharma, Ashish (1)
- Sharrett, Richey (1)
- Shelip, Alla (1)
- Shemer, Yuval (1)
- Shlipak, Michael G. (1)
- Shlyakhto, Evgeny (1)
- Short, Andrea (1)
- Shulman, Rita (1)
- Siebolts, Udo (1)
- Siedel, Claudia (1)
- Sigala, Sandra (1)
- Simmenroth, Anne (1)
- Simon, Michael S. (1)
- Sinitsyn, Valentin (1)
- Sipos, Bence (1)
- Siren, Anna-Leena (1)
- Siscovick, David (1)
- Sitter, Magdalena (1)
- Siwy, Justyna (1)
- Skinningsrud, Beate (1)
- Skowasch, Dirk (1)
- Smaxwil, Constantin (1)
- Smiles, Adam M. (1)
- Smith, David J. (1)
- Smith, Michael W. (1)
- Snyder, Holly J. (1)
- Soares, Iberê Cauduro (1)
- Solá, Laura (1)
- Sommer, Kim K. (1)
- Sommerer, Claudia (1)
- Song, Moshi (1)
- Sonneveld, Pieter (1)
- Sonntagbauer, Michael (1)
- Sorger, Lena (1)
- Sossalla, Samuel (1)
- Sossalla, Samuel T. (1)
- Sotnikova, Evgeniia (1)
- Spada, Anna (1)
- Spasovski, Goce (1)
- Sperlich, Billy (1)
- Spiekermann, K (1)
- Spustová, Viera (1)
- Spyridopoulos, Ioakim (1)
- Sritara, Piyamitr (1)
- Srivastava, Mugdha (1)
- Srougi, Victor (1)
- Stach, Michael (1)
- Staib, P (1)
- Stalla, Günter K. (1)
- Stalleicken, Dirk (1)
- Stebani, Jannik (1)
- Stefanescu, Maria Roxana (1)
- Stefanick, Marcia (1)
- Stefenelli, Ulrich (1)
- Steffen, Lyn M. (1)
- Steger, U. (1)
- Steinbrunn, Torsten (1)
- Steinfeldt, Thorsten (1)
- Stel, Vianda S. (1)
- Stell, Anthony (1)
- Stengel, Benedicte (1)
- Stengel, Bénédicte (1)
- Stenvinkel, Peter (1)
- Stenzinger, Albrecht (1)
- Stephens, Owen W. (1)
- Stewart, Paul M. (1)
- Stich, August (1)
- Stiekema, Han (1)
- Stigliano, Antonio (1)
- Stippel, Dirk (1)
- Stojakovic, Tatjana (1)
- Stopper, Helga (1)
- Stork, S. (1)
- Stork, Stefan (1)
- Stork, Tabea (1)
- Storms, Sebastian (1)
- Straka, Samantha (1)
- Stratakis, Constantine A. (1)
- Strate, Alexander (1)
- Strauss, Konrad (1)
- Strauss, Olaf (1)
- Strekalova, Tatyana (1)
- Stritt, Simon (1)
- Strobel, Sabrina (1)
- Stroncek, David F (1)
- Stumpner, Jan (1)
- Stühmer, Thorsten (1)
- Sugeng, Lissa (1)
- Surat, Güzin (1)
- Surjanto, Jessica (1)
- Suzuki, Hitoshi (1)
- Svarstad, Einar (1)
- Swaminathan, Bhairavi (1)
- Swinkels, Dorine W. (1)
- Sy, Rody (1)
- Szalay, Aladar A (1)
- Süleymanlar, Gültekin (1)
- Taleh, Scharoch (1)
- Tall, Alan (1)
- Tamburello, Mariangela (1)
- Tan, Chee Eng (1)
- Tang, Weihong (1)
- Tanno, Fabio (1)
- Taylor, Angela E. (1)
- Taylor, Kent D. (1)
- Tegner, Jesper (1)
- Tejman-Yarden, Shai (1)
- Terekhov, Maxim (1)
- Terhorst, Yannik (1)
- Tesar, Vladimir (1)
- Teumer, Alexander (1)
- Thadhani, Ravi I. (1)
- Thameem, Farook (1)
- Thereska, Nestor (1)
- Thibaudin, Lise (1)
- Thomas, Daniel (1)
- Thomas, Lena (1)
- Thomas, Merlin C. (1)
- Thompson, Lester D. R. (1)
- Thomsen, Hauke (1)
- Thorban, Stefan (1)
- Thornley-Brown, Denyse P. (1)
- Tian, Geng (1)
- Tian, Si-Miao (1)
- Timmermann, Beate (1)
- Tinnevelt, Gerjen H. (1)
- Tirilomis, Petros (1)
- Tischer, Johanna (1)
- Titze, Stephanie (1)
- Titze, Stephanie I. (1)
- Tng, Priscilla Y. (1)
- Tobias, Deirdre K. (1)
- Toepfer, Martin (1)
- Toischer, Karl (1)
- Tokgözoğlu, Lale (1)
- Tolksdorf, Johanna (1)
- Tolstik, Elen (1)
- Tomilina, Natalia (1)
- Torje, Iuliu (1)
- Torpy, David J. (1)
- Torres-Ruiz, Raúl (1)
- Toth, Peter P. (1)
- Trader, Jens-Martin (1)
- Truitt, Barbara J. (1)
- Tryfonidou, Marianna A. (1)
- Träder, Jens-Martin (1)
- Tröger, Viola (1)
- Turesson, Ingemar (1)
- Turkin, Irina (1)
- Turro, Ernest (1)
- Uccellini, Lorenzo (1)
- Uitterlinden, André (1)
- Ullrich, Melanie (1)
- Ulmer, Tom F. (1)
- Undlien, Dag (1)
- Ungemach-Papenberg, Peter (1)
- Ungethüm, K. (1)
- Ungethüm, Kathrin (1)
- Urlaub, Daniela (1)
- Uttinger, Konstantin (1)
- Valensi, Paul (1)
- Van Kralingen, Josie (1)
- Van Stralen, Karlijn (1)
- Vangsted, Annette (1)
- Vanselow, Jens T. (1)
- Vaziri, Nosratola D. (1)
- Vela, Emili (1)
- Velickovski, Filip (1)
- Ventz, Manfred (1)
- Verde, Ludovica (1)
- Verga, Uberta (1)
- Verrua, Elisa (1)
- Vetrani, Claudia (1)
- Vettorazzi, Eik (1)
- Viktorin, Alexander (1)
- Vila, Greisa (1)
- Virgone, Calogero (1)
- Visan, Ioana Andreea (1)
- Vlietstra, Wytze J. (1)
- Vogel, Benjamin (1)
- Vogel, Carsten (1)
- Vogel, Ulla (1)
- Vogg, Nora Johanna (1)
- Vogt, Marius (1)
- Volante, Marco (1)
- Voll, Sabine (1)
- Völker, Katharina (1)
- Waage, Anders (1)
- Wagenhäuser, Isabell (1)
- Wagenhäuser, L. (1)
- Wagenhäuser, Laura (1)
- Wagner, M. (1)
- Wagner, Nicole (1)
- Wahlberg, Jeanette (1)
- Walker, Brian A. (1)
- Wallace, Robert B. (1)
- Waller, Christiane (1)
- Walles, Thorsten (1)
- Walz, Katharina (1)
- Wang, Ben-Jie (1)
- Wang, Ena (1)
- Wang, Nan (1)
- Wang, Wei (1)
- Wangorsch, Gaby (1)
- Warrings, Bodo (1)
- Watts, Deepika (1)
- Weber, Justus C. (1)
- Weber, Oliver M. (1)
- Weber, Wolfgang A. (1)
- Wech, Tobias (1)
- Wedekink, Florian (1)
- Weekers, Laurent (1)
- Wehmeier, A (1)
- Wei, Xiao-Wei (1)
- Wei, Yu-Shan (1)
- Weil, E. Jennifer (1)
- Weimer, Rolf (1)
- Weinhold, Niels (1)
- Weinmann‐Menke, Julia (1)
- Weinstock, Joshua S. (1)
- Weiss, Günter (1)
- Weissbrich, Benedikt (1)
- Weisser, Christoph (1)
- Weiß, Emil (1)
- Weiß, Martin (1)
- Welsch, Stefan (1)
- Wende, Christian Michael (1)
- Wendlinger, Simone (1)
- Weng, A. M. (1)
- Weng, Andreas M. (1)
- Wennmann, Andreas (1)
- West, Michael L. (1)
- Wester, Hans-Juergen (1)
- Wester, Hans-Jürgen (1)
- Westermaier, Thomas (1)
- Westerteicher, Christoph (1)
- Wevers, Ron A. (1)
- Wheeler, David C. (1)
- Whitsel, Eric (1)
- Wichmann, H.-Erich (1)
- Wiedemann, Frank (1)
- Wiedemann, Sophia Julia (1)
- Wiedmann, S. (1)
- Wiedmann, Silke (1)
- Wiegering, Verena A. (1)
- Wielockx, Ben (1)
- Wihlborg, Anna-Karin (1)
- Wikstrand, John (1)
- Wilhelm, M (1)
- Wilkesmann, Joana (1)
- Willenberg, Holger S. (1)
- Williams, Tracy A. (1)
- Winkler, Cheryl A. (1)
- Winkler, Marcela (1)
- Winter, Patrick M. (1)
- Wintzheimer, Stefan (1)
- Winzeler, Bettina (1)
- Wischhusen, Jörg (1)
- Wistuba-Hamprecht, Kilian (1)
- Witteman, Jacqueline (1)
- Wittes, Janet (1)
- Woerle, Hans-Juergen (1)
- Woerle, Hans-Jürgen (1)
- Wohlfarth, Jonas (1)
- Wohlgemuth, Walter (1)
- Wolf, Gunter (1)
- Wolff, Anette S. B. (1)
- Wolfsberger, Stefan (1)
- Wolz, Constanze (1)
- Wood, D. (1)
- Worschech, Andrea (1)
- Wulf, G (1)
- Wurmb, Thomas (1)
- Wyatt, Robert J. (1)
- Wörsdörfer, Philipp (1)
- Wünsche, Christoph M. (1)
- Wüthrich, Rudolf P. (1)
- Xie, Hui (1)
- Xie, Jingyuan (1)
- Xu, Anton (1)
- Xu, Yong-Qing (1)
- Yalcin, Bilgehan (1)
- Yang, Fan (1)
- Yang, Lei (1)
- Yang, Meng (1)
- Yang, Qiong (1)
- Ye, Yu-Xiang (1)
- Yifu, Li (1)
- Yoo, Han-Wook (1)
- Ysebaert, Dirk (1)
- Yu, Mang (1)
- Yu, Zhiya (1)
- Zacharowski, Kai (1)
- Zager, Philip G. (1)
- Zamboli, Pasquale (1)
- Zambon, Albertro (1)
- Zander, A (1)
- Zanen, Peter (1)
- Zang, Yu-Qiang (1)
- Zausig, York (1)
- Zeller, Daniel (1)
- Zerbini, Maria Claudia Nogueira (1)
- Zeymer, Uwe (1)
- Zhang, Hong (1)
- Zhang, Luxia (1)
- Zhao, De-Wei (1)
- Zharikova, Anastasia (1)
- Zhu, Junren (1)
- Zielke, Andreas (1)
- Zierler, Susanna (1)
- Zimmer, Michael (1)
- Zimmermann, Josef (1)
- Zimmet, Paul (1)
- Zopf, Kathrin (1)
- Zovato, Stefania (1)
- Zsótér, Norbert (1)
- Zugck, Christian (1)
- Zurawek, Magdalena (1)
- da Silva Filho, Miguel Inacio (1)
- de Latour, Bertrand Richard (1)
- de Pablos, Carmen Santiuste (1)
- de Vries, Erwin (1)
- de Zeeuw, Dick (1)
- de la Nuez, Pablo Castro (1)
- de la Torre, Ramón Alonso (1)
- de la Tour, Régis Pefault (1)
- de los Ángeles García Bazaga, Maria (1)
- di Dalmazi, Guido (1)
- di Ruffano, Lavinia Ferrante (1)
- van Duin, Mark (1)
- van Dussen, Laura (1)
- van Eeuwijk, Judith M.M. (1)
- van Kuilenburg, André B.P. (1)
- van Meel, Marieke (1)
- van Zyl, Gert (1)
- van den Berg, Anne Maria (1)
- van der Veen, Sanne J. (1)
- von Ehrlich-Treuenstätt, Viktor (1)
- von Eynatten, Maximilian (1)
- von Haehling, Stephan (1)
- von Rahden, Burkhard H. (1)
- Álvarez-Escolá, Cristina (1)
- Öner, Alper (1)
- Üceyler, Nurcan (1)
- Üçeyler, N. (1)
- Čala, Svjetlana (1)
- Šebeková, Katarína (1)
Institute
- Medizinische Klinik und Poliklinik I (335) (remove)
Sonstige beteiligte Institutionen
- Zentraleinheit Klinische Massenspektrometrie (3)
- Johns Hopkins School of Medicine, Baltimore, MD, U.S. (2)
- Apotheke, Universitätsklinikum Würzburg (1)
- Center for Interdisciplinary Clinical Research, Würzburg University, Würzburg, Germany (1)
- Datenintegrationszentrum Würzburg (DIZ) (1)
- Hospital Augsburg, Augsburg, Germany (1)
- Interdisziplinäre Biomaterial- und Datenbank Würzburg (ibdw) (1)
- Johns Hopkins School of Medicine (1)
- Johns Hopkins University School of Medicine (1)
- Klinische Studienzentrale (Universitätsklinikum) (1)
Janz, Anna ; Walz, Katharina ; Cirnu, Alexandra ; Surjanto, Jessica ; Urlaub, Daniela ; Leskien, Miriam ; Kohlhaas, Michael ; Nickel, Alexander ; Brand, Theresa ; Nose, Naoko ; Wörsdörfer, Philipp ; Wagner, Nicole ; Higuchi, Takahiro ; Maack, Christoph ; Dudek, Jan ; Lorenz, Kristina ; Klopocki, Eva ; Ergün, Süleyman ; Duff, Henry J. ; Gerull, Brenda
Highlights
• Loss of DNAJC19's DnaJ domain disrupts cardiac mitochondrial structure, leading to abnormal cristae formation in iPSC-CMs.
• Impaired mitochondrial structures lead to an increased mitochondrial respiration, ROS and an elevated membrane potential.
• Mutant iPSC-CMs show sarcomere dysfunction and a trend to more arrhythmias, resembling DCMA-associated cardiomyopathy.
Background
Dilated cardiomyopathy with ataxia (DCMA) is an autosomal recessive disorder arising from truncating mutations in DNAJC19, which encodes an inner mitochondrial membrane protein. Clinical features include an early onset, often life-threatening, cardiomyopathy associated with other metabolic features. Here, we aim to understand the metabolic and pathophysiological mechanisms of mutant DNAJC19 for the development of cardiomyopathy.
Methods
We generated induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) of two affected siblings with DCMA and a gene-edited truncation variant (tv) of DNAJC19 which all lack the conserved DnaJ interaction domain. The mutant iPSC-CMs and their respective control cells were subjected to various analyses, including assessments of morphology, metabolic function, and physiological consequences such as Ca\(^{2+}\) kinetics, contractility, and arrhythmic potential. Validation of respiration analysis was done in a gene-edited HeLa cell line (DNAJC19tv\(_{HeLa}\)).
Results
Structural analyses revealed mitochondrial fragmentation and abnormal cristae formation associated with an overall reduced mitochondrial protein expression in mutant iPSC-CMs. Morphological alterations were associated with higher oxygen consumption rates (OCRs) in all three mutant iPSC-CMs, indicating higher electron transport chain activity to meet cellular ATP demands. Additionally, increased extracellular acidification rates suggested an increase in overall metabolic flux, while radioactive tracer uptake studies revealed decreased fatty acid uptake and utilization of glucose. Mutant iPSC-CMs also showed increased reactive oxygen species (ROS) and an elevated mitochondrial membrane potential. Increased mitochondrial respiration with pyruvate and malate as substrates was observed in mutant DNAJC19tv HeLa cells in addition to an upregulation of respiratory chain complexes, while cellular ATP-levels remain the same. Moreover, mitochondrial alterations were associated with increased beating frequencies, elevated diastolic Ca\(^{2+}\) concentrations, reduced sarcomere shortening and an increased beat-to-beat rate variability in mutant cell lines in response to β-adrenergic stimulation.
Conclusions
Loss of the DnaJ domain disturbs cardiac mitochondrial structure with abnormal cristae formation and leads to mitochondrial dysfunction, suggesting that DNAJC19 plays an essential role in mitochondrial morphogenesis and biogenesis. Moreover, increased mitochondrial respiration, altered substrate utilization, increased ROS production and abnormal Ca\(^{2+}\) kinetics provide insights into the pathogenesis of DCMA-related cardiomyopathy.
Kerwagen, Fabian ; Riemer, Uwe ; Wachter, Rolf ; von Haehling, Stephan ; Abdin, Amr ; Böhm, Michael ; Schulz, Martin ; Störk, Stefan
Background
Guideline-directed medical therapy (GDMT) is the cornerstone in the treatment of patients with heart failure and reduced ejection fraction (HFrEF) and novel substances such as sacubitril/valsartan (S/V) and sodium-glucose co-transporter-2 inhibitors (SGLT2i) have demonstrated marked clinical benefits. We investigated their implementation into real-world HF care in Germany before, during, and after the COVID-19 pandemic period.
Methods
The IQVIA LRx data set is based on ∼80% of 73 million people covered by the German statutory health insurance. Prescriptions of S/V were used as a proxy for HFrEF. Time trends were analysed between Q1/2016 and Q2/2023 for prescriptions for S/V alone and in combination therapy with SGLT2i.
Findings
The number of patients treated with S/V increased from 5260 in Q1/2016 to 351,262 in Q2/2023. The share of patients with combination therapy grew from 0.6% (29 of 5260) to 14.2% (31,128 of 219,762) in Q2/2021, and then showed a steep surge up to 54.8% (192,429 of 351,262) in Q2/2023, coinciding with the release of the European Society of Cardiology (ESC) guidelines for HF in Q3/2021. Women and patients aged >80 years were treated less often with combined therapy than men and younger patients. With the start of the COVID-19 pandemic, the number of patients with new S/V prescriptions dropped by 17.5% within one quarter, i.e., from 26,855 in Q1/2020 to 22,145 in Q2/2020, and returned to pre-pandemic levels only in Q1/2021.
Interpretation
The COVID-19 pandemic was associated with a 12-month deceleration of S/V uptake in Germany. Following the release of the ESC HF guidelines, the combined prescription of S/V and SGLT2i was readily adopted. Further efforts are needed to fully implement GDMT and strengthen the resilience of healthcare systems during public health crises.
Buck, Andreas K. ; Serfling, Sebastian E. ; Lindner, Thomas ; Hänscheid, Heribert ; Schirbel, Andreas ; Hahner, Stefanie ; Fassnacht, Martin ; Einsele, Hermann ; Werner, Rudolf A.
A growing body of literature reports on the upregulation of C-X-C motif chemokine receptor 4 (CXCR4) in a variety of cancer entities, rendering this receptor as suitable target for molecular imaging and endoradiotherapy in a theranostic setting. For instance, the CXCR4-targeting positron emission tomography (PET) agent [\(^{68}\)Ga]PentixaFor has been proven useful for a comprehensive assessment of the current status quo of solid tumors, including adrenocortical carcinoma or small-cell lung cancer. In addition, [\(^{68}\)Ga]PentixaFor has also provided an excellent readout for hematological malignancies, such as multiple myeloma, marginal zone lymphoma, or mantle cell lymphoma. PET-based quantification of the CXCR4 capacities in vivo allows for selecting candidates that would be suitable for treatment using the theranostic equivalent [\(^{177}\)Lu]/[\(^{90}\)Y]PentixaTher. This CXCR4-directed theranostic concept has been used as a conditioning regimen prior to hematopoietic stem cell transplantation and to achieve sufficient anti-lymphoma/-tumor activity in particular for malignant tissues that are highly sensitive to radiation, such as the hematological system. Increasing the safety margin, pretherapeutic dosimetry is routinely performed to determine the optimal activity to enhance therapeutic efficacy and to reduce off-target adverse events. The present review will provide an overview of current applications for CXCR4-directed molecular imaging and will introduce the CXCR4-targeted theranostic concept for advanced hematological malignancies.
Altieri, Barbara ; La Salvia, Anna ; Modica, Roberta ; Marciello, Francesca ; Mercier, Olaf ; Filosso, Pier Luigi ; de Latour, Bertrand Richard ; Giuffrida, Dario ; Campione, Severo ; Guggino, Gianluca ; Fadel, Elie ; Papotti, Mauro ; Colao, Annamaria ; Scoazec, Jean-Yves ; Baudin, Eric ; Faggiano, Antongiulio
Background: Large Cell Neuroendocrine Carcinoma (LCNEC) is a rare subtype of lung cancer with poor clinical outcomes. Data on recurrence-free survival (RFS) in early and locally advanced pure LCNEC after complete resection (R0) are lacking. This study aims to evaluate clinical outcomes in this subgroup of patients and to identify potential prognostic markers. Methods: Retrospective multicenter study including patients with pure LCNEC stage I-III and R0 resection. Clinicopathological characteristics, RFS, and disease-specific survival (DSS) were evaluated. Univariate and multivariate analyses were performed. Results: 39 patients (M:F = 26:13), with a median age of 64 years (44–83), were included. Lobectomy (69.2%), bilobectomy (5.1%), pneumonectomy (18%), and wedge resection (7.7%) were performed mostly associated with lymphadenectomy. Adjuvant therapy included platinum-based chemotherapy and/or radiotherapy in 58.9% of cases. After a median follow-up of 44 (4–169) months, the median RFS was 39 months with 1-, 2- and 5-year RFS rates of 60.0%, 54.6%, and 44.9%, respectively. Median DSS was 72 months with a 1-, 2- and 5-year rate of 86.8, 75.9, and 57.4%, respectively. At multivariate analysis, age (cut-off 65 years old) and pN status were independent prognostic factors for both RFS (HR = 4.19, 95%CI = 1.46–12.07, p = 0.008 and HR = 13.56, 95%CI 2.45–74.89, p = 0.003, respectively) and DSS (HR = 9.30, 95%CI 2.23–38.83, p = 0.002 and HR = 11.88, 95%CI 2.28–61.84, p = 0.003, respectively). Conclusion: After R0 resection of LCNEC, half of the patients recurred mostly within the first two years of follow-up. Age and lymph node metastasis could help to stratify patients for adjuvant therapy.
Modica, Roberta ; Altieri, Barbara ; D’Aniello, Francesco ; Benevento, Elio ; Cannavale, Giuseppe ; Minotta, Roberto ; Liccardi, Alessia ; Colao, Annamaria ; Faggiano, Antongiulio
Neurofibromatosis type 1 (NF1) is a genetic multisystemic autosomal dominant disorder determining reduced life expectancy due to higher risk of developing benign and malignant tumors. Low levels of vitamin D and reduced bone mineral density (BMD) have been reported in young patients with NF1. However, correlation between vitamin D and NF1 phenotype needs to be elucidated. Aim of this study was to assess vitamin D levels and bone metabolism in NF1 patients, analyzing potential correlations with clinical phenotype. A cross-sectional study was carried out in a monocentric series of NF1 patients, evaluating genotype, clinical phenotype, BMD, biochemical evaluation with focus on serum 25OH-vitamin D, parathyroid hormone (PTH), calcium and phosphate levels. Correlations between clinical manifestations, neurofibromas, and vitamin D status have been studied in comparison with healthy controls. 31 NF1 adult patients were matched for sex, age and body mass index with 31 healthy controls. A significantly difference in vitamin D level emerged in NF1 patients compared to controls. Interestingly low vitamin D levels correlated with a more aggressive phenotype and with a bigger size of neurofibromas. These data underline that vitamin D deficiency/insufficiency may play a role in clinical severity of neurofibromas in patients with NF1, suggesting the need to check bone status and replace vitamin D in these patients.
Serfling, Sebastian E. ; Lapa, Constantin ; Dreher, Niklas ; Hartrampf, Philipp E. ; Rowe, Steven P. ; Higuchi, Takahiro ; Schirbel, Andreas ; Weich, Alexander ; Hahner, Stefanie ; Fassnacht, Martin ; Buck, Andreas K. ; Werner, Rudolf A.
Background
CXCR4-directed positron emission tomography/computed tomography (PET/CT) has been used as a diagnostic tool in patients with solid tumors. We aimed to determine a potential correlation between tumor burden and radiotracer accumulation in normal organs.
Methods
Ninety patients with histologically proven solid cancers underwent CXCR4-targeted [\(^{68}\)Ga]Ga-PentixaFor PET/CT. Volumes of interest (VOIs) were placed in normal organs (heart, liver, spleen, bone marrow, and kidneys) and tumor lesions. Mean standardized uptake values (SUV\(_{mean}\)) for normal organs were determined. For CXCR4-positive tumor burden, maximum SUV (SUV\(_{max}\)), tumor volume (TV), and fractional tumor activity (FTA, defined as SUV\(_{mean}\) x TV), were calculated. We used a Spearman's rank correlation coefficient (ρ) to derive correlative indices between normal organ uptake and tumor burden.
Results
Median SUV\(_{mean}\) in unaffected organs was 5.2 for the spleen (range, 2.44 – 10.55), 3.27 for the kidneys (range, 1.52 – 17.4), followed by bone marrow (1.76, range, 0.84 – 3.98), heart (1.66, range, 0.88 – 2.89), and liver (1.28, range, 0.73 – 2.45). No significant correlation between SUV\(_{max}\) in tumor lesions (ρ ≤ 0.189, P ≥ 0.07), TV (ρ ≥ -0.204, P ≥ 0.06) or FTA (ρ ≥ -0.142, P ≥ 0.18) with the investigated organs was found.
Conclusions
In patients with solid tumors imaged with [\(^{68}\)Ga]Ga-PentixaFor PET/CT, no relevant tumor sink effect was noted. This observation may be of relevance for therapies with radioactive and non-radioactive CXCR4-directed drugs, as with increasing tumor burden, the dose to normal organs may remain unchanged.
Kimpel, Otilia ; Schindler, Paul ; Schmidt-Pennington, Laura ; Altieri, Barbara ; Megerle, Felix ; Haak, Harm ; Pittaway, James ; Dischinger, Ulrich ; Quinkler, Marcus ; Mai, Knut ; Kroiss, Matthias ; Polat, Bülent ; Fassnacht, Martin
Background
International guidelines emphasise the role of radiotherapy (RT) for the management of advanced adrenocortical carcinoma (ACC). However, the evidence for this recommendation is very low.
Methods
We retrospectively analysed all patients who received RT for advanced ACC in five European centres since 2000. Primary endpoint: time to progression of the treated lesion (tTTP). Secondary endpoints: best objective response, progression-free survival (PFS), overall survival (OS), adverse events, and the establishment of predictive factors by Cox analyses.
Results
In total, 132 tumoural lesions of 80 patients were treated with conventional RT (cRT) of 50–60 Gy (n = 20) or 20–49 Gy (n = 69), stereotactic body RT of 35–50 Gy (SBRT) (n = 36), or brachytherapy of 12–25 Gy (BT) (n = 7). Best objective lesional response was complete (n = 6), partial (n = 52), stable disease (n = 60), progressive disease (n = 14). Median tTTP was 7.6 months (1.0–148.6). In comparison to cRT\(_{20-49Gy}\), tTTP was significantly longer for cRT\(_{50-60Gy}\) (multivariate adjusted HR 0.10; 95% CI 0.03–0.33; p < 0.001) and SBRT (HR 0.31; 95% CI 0.12–0.80; p = 0.016), but not for BT (HR 0.66; 95% CI 0.22–1.99; p = 0.46). Toxicity was generally mild and moderate with three grade 3 events. No convincing predictive factors could be established.
Conclusions
This largest published study on RT in advanced ACC provides clear evidence that RT is effective in ACC.
Tamburello, Mariangela ; Altieri, Barbara ; Sbiera, Iuliu ; Sigala, Sandra ; Berruti, Alfredo ; Fassnacht, Martin ; Sbiera, Silviu
FGF/FGFR signaling regulates embryogenesis, angiogenesis, tissue homeostasis and wound repair by modulating proliferation, differentiation, survival, migration and metabolism of target cells. Understandably, compelling evidence for deregulated FGF signaling in the development and progression of different types of tumors continue to emerge and FGFR inhibitors arise as potential targeted therapeutic agents, particularly in tumors harboring aberrant FGFR signaling. There is first evidence of a dual role of the FGF/FGFR system in both organogenesis and tumorigenesis, of which this review aims to provide an overview. FGF-1 and FGF-2 are expressed in the adrenal cortex and are the most powerful mitogens for adrenocortical cells. Physiologically, they are involved in development and maintenance of the adrenal gland and bind to a family of four tyrosine kinase receptors, among which FGFR1 and FGFR4 are the most strongly expressed in the adrenal cortex. The repeatedly proven overexpression of these two FGFRs also in adrenocortical cancer is thus likely a sign of their participation in proliferation and vascularization, though the exact downstream mechanisms are not yet elucidated. Thus, FGFRs potentially offer novel therapeutic targets also for adrenocortical carcinoma, a type of cancer resistant to conventional antimitotic agents.
Adoptive immunotherapy using chimeric antigen receptor (CAR)-modified T cells is an effective treatment for hematological malignancies that are refractory to conventional chemotherapy. To address a wider variety of cancer entities, there is a need to identify and characterize additional target antigens for CAR-T cell therapy. The two members of the receptor tyrosine kinase-like orphan receptor family, ROR1 and ROR2, have been found to be overexpressed on cancer cells and to correlate with aggressive cancer phenotypes. Recently, ROR1-specific CAR-T cells have entered testing in phase I clinical trials, encouraging us to assess the suitability of ROR2 as a novel target for CAR-T cell therapy. To study the therapeutic potential of targeting ROR2 in solid and hematological malignancies, we selected two representative cancer entities with high unmet medical need: renal cell carcinoma and multiple myeloma.
Our data show that ROR2 is commonly expressed on primary samples and cell lines of clear cell renal cell carcinoma and multiple myeloma. To study the efficacy of ROR2-specific CAR T cell therapy, we designed two CAR constructs with 10-fold binding affinity differences for the same epitope of ROR2. We found both cell products to exhibit antigen-specific anti-tumor reactivity in vitro, including tumor cell lysis, secretion of the effector cytokines interleukin-2 (IL-2) and interferon-gamma (IFNγ), and T cell proliferation. In vivo studies revealed ROR2 specific CAR-T cells to confer durable responses, significant survival benefits and long-term persistence of CAR-expressing T cells. Overall, there was a trend towards more potent anti-tumor efficacy upon treatment with T cells that expressed the CAR with higher affinity for ROR2, both in vitro and in vivo.
We performed a preclinical safety and toxicology assessment comprising analyses of ROR2 expression in healthy human and murine tissues, cross-reactivity, and adoptive T cell transfer in immunodeficient mice. We found ROR2 expression to be conserved in mice, and low-level expression was detectable in the male and female reproductive system as well as parts of the gastrointestinal tract. CAR-T cells targeting human ROR2 were found to elicit similarly potent reactivity upon recognition of murine ROR2. In vivo analyses showed transient tissue-specific enrichment and activation of ROR2-specific CAR-T cells in organs with high blood circulation, such as lung, liver, or spleen, without evidence for clinical toxicity or tissue damage as determined by histological analyses.
Furthermore, we humanized the CAR binding domain of ROR2-specific CAR-T cells to mitigate the risk of adverse immune reactions and concomitant CAR-T cell rejection. Functional analyses confirmed that humanized CARs retained their specificity and functionality against ROR2-positive tumor cells in vitro.
In summary, we show that ROR2 is a prevalent target in RCC and MM, which can be addressed effectively with ROR2-specific CAR-T cells in preclinical models. Our preliminary toxicity studies suggest a favorable safety profile for ROR2-specific CAR-T cells. These findings support the potential to develop ROR2-specific CAR-T cells clinically to obtain cell products with broad utility.