Refine
Has Fulltext
- yes (1032)
Is part of the Bibliography
- yes (1032) (remove)
Year of publication
- 2022 (1032) (remove)
Document Type
- Journal article (808)
- Doctoral Thesis (199)
- Working Paper (7)
- Preprint (4)
- Report (3)
- Book (2)
- Book article / Book chapter (2)
- Master Thesis (2)
- Review (2)
- Bachelor Thesis (1)
Language
- English (1032) (remove)
Keywords
- COVID-19 (16)
- SARS-CoV-2 (11)
- machine learning (11)
- virtual reality (11)
- heart failure (10)
- prostate cancer (10)
- inflammation (9)
- remote sensing (9)
- 3D printing (8)
- Germany (8)
Institute
- Theodor-Boveri-Institut für Biowissenschaften (130)
- Graduate School of Life Sciences (79)
- Institut für Informatik (56)
- Medizinische Klinik und Poliklinik I (56)
- Neurologische Klinik und Poliklinik (54)
- Medizinische Klinik und Poliklinik II (50)
- Institut für Geographie und Geologie (48)
- Klinik und Poliklinik für Anästhesiologie (ab 2004) (44)
- Institut für Organische Chemie (41)
- Institut für Psychologie (39)
Schriftenreihe
Sonstige beteiligte Institutionen
- IZKF Nachwuchsgruppe Geweberegeneration für muskuloskelettale Erkrankungen (5)
- Bernhard-Heine-Centrum für Bewegungsforschung (4)
- Zentraleinheit Klinische Massenspektrometrie (3)
- Fraunhofer-Institut für Silicatforschung ISC (2)
- Helmholtz Institute for RNA-based Infection Research (HIRI) (2)
- Krankenhaushygiene und Antimicrobial Stewardship (Universitätsklinikum) (2)
- Wilhelm-Conrad-Röntgen-Forschungszentrum für komplexe Materialsysteme (2)
- ALPARC - The Alpine Network of Protected Areas (1)
- Albert-Ludwigs-Universität Freiburg (1)
- Arizona State University, Tempe, Arizona, USA (1)
Objectives
The pathogenesis of fibromyalgia syndrome (FMS) is unclear. Transcranial ultrasonography revealed anechoic alteration of midbrain raphe in depression and anxiety disorders, suggesting affection of the central serotonergic system. Here, we assessed midbrain raphe echogenicity in FMS.
Methods
Sixty-six patients underwent transcranial sonography, of whom 53 were patients with FMS (27 women, 26 men), 13 patients with major depression and physical pain (all women), and 14 healthy controls (11 women, 3 men). Raphe echogenicity was graded visually as normal or hypoechogenic, and quantified by digitized image analysis, each by investigators blinded to the clinical diagnosis.
Results
Quantitative midbrain raphe echogenicity was lower in patients with FMS compared to healthy controls (p<0.05), but not different from that of patients with depression and accompanying physical pain. Pain and FMS symptom burden did not correlate with midbrain raphe echogenicity as well as the presence and severity of depressive symptoms.
Conclusion
We found reduced echogenicity of the midbrain raphe area in patients with FMS and in patients with depression and physical pain, independent of the presence or severity of pain, FMS, and depressive symptoms. Further exploration of this sonographic finding is necessary before this objective technique may enter diagnostic algorithms in FMS and depression.
Studies in Modern English
(2022)
The book "Studies in Modern English" interprets English-language communication in the humanitarian paradigm of knowledge within the linguistic and psycho-sociocultural study of speech activity prioritizing cognitive and communicative paradigms. Digital discourse as the formation of new semiotic phenomena has crowned the rapid scientific and technological progress. Researchers' scientific achievements represented in the book are systemic and valid in terms of evidence-based narratives, which reflect the transformational horizon of information theory, communication theory, and theory of linguodidactics in modern English verbal, creative and digital environments. The book represents an integrated approach to the study of modern English as an open synergetic system, which requires a description of the relationship between verbal and nonverbal notions in digital space. The book integrates such innovative perspectives as the interaction of natural English and programming languages, cyber aggression as a communicative pattern in English-language digital discourse, ethics, and democratization of modern English language, relevant developments in the field of English language as a Foreign Language, and other related issues. A complex focus of the book in the realm of modern English-language communication concerns verbal and nonverbal notions analyzed in the context of socio-cultural and digital communicative spaces.