Refine
Has Fulltext
- yes (506)
Is part of the Bibliography
- yes (506)
Year of publication
- 2012 (506) (remove)
Document Type
- Journal article (364)
- Doctoral Thesis (133)
- Preprint (3)
- Review (3)
- Book (1)
- Conference Proceeding (1)
- Report (1)
Language
- English (506) (remove)
Keywords
- Medizin (42)
- hadron-hadron scattering (15)
- Biologie (13)
- Psychologie (12)
- systematic uncertainty (9)
- cancer (8)
- gene expression (8)
- melanoma (8)
- expression (7)
- jet energy scale (7)
- protein (7)
- brain (6)
- differentiation (6)
- in vitro (6)
- ATLAS (5)
- Apoptosis (5)
- Chemie (5)
- Maus (5)
- apoptosis (5)
- binding (5)
- genome-wide association (5)
- mice (5)
- therapy (5)
- transverse momentum (5)
- Atlas detector (4)
- Drosophila (4)
- HIV (4)
- Melanom (4)
- Taufliege (4)
- Vaccinia-Virus (4)
- cells (4)
- disease (4)
- emotion (4)
- gene (4)
- genetics (4)
- identification (4)
- inhibitor (4)
- jet energy resolution (4)
- lung cancer (4)
- messenger RNA (4)
- metaanalysis (4)
- model (4)
- neuroprotection (4)
- oncolytic virotherapy (4)
- receptor (4)
- resistance (4)
- signal transduction (4)
- single-crystal X-ray study (4)
- survival (4)
- tumors (4)
- vaccinia virus (4)
- validation (4)
- Dendritische Zelle (3)
- Evolution (3)
- Fuchsbandwurm (3)
- Genexpression (3)
- Knockout <Molekulargenetik> (3)
- Lungenkrebs (3)
- MC simulation (3)
- MRI (3)
- Modellierung (3)
- Myc (3)
- Perylenderivate (3)
- Pneumolysin (3)
- SM background (3)
- T cells (3)
- Zelldifferenzierung (3)
- association (3)
- breast-tumors (3)
- central-nervous-system (3)
- children (3)
- classification (3)
- colony-stimulating factor (3)
- combination therapy (3)
- epithelial cells (3)
- escherichia coli (3)
- genes (3)
- jet energy scale uncertainty (3)
- light quark jet (3)
- lung (3)
- magnetic resonance imaging (3)
- malaria (3)
- multijet background (3)
- multiple sclerosis (3)
- non-prompt lepton (3)
- onkolytische Virotherapie (3)
- oxidative stress (3)
- progression (3)
- quality of life (3)
- serum (3)
- stem cells (3)
- stroke (3)
- top quark mass (3)
- top quark pair (3)
- trial (3)
- ubiquitin (3)
- 5-HT1A (2)
- 5-HT2C (2)
- ADHD (2)
- Alzheimers disease (2)
- Anti-k Jet (2)
- Apoptose (2)
- Arzneimitteldesign (2)
- Ausbreitung (2)
- BDNF (2)
- Bakteriengift (2)
- Biochemie (2)
- Cl Lowe limit (2)
- DNA repair (2)
- Datenbank (2)
- Dendritic cell (2)
- Deutschland (2)
- Diabetes mellitus (2)
- Drugs (2)
- EF-1A (2)
- Echinococcus (2)
- Embryonale Stammzelle (2)
- Extrazelluläre Matrix (2)
- Extremwertstatistik (2)
- FAAH (2)
- Geruchssinn (2)
- Graphen (2)
- Heterostruktur (2)
- Hey (2)
- Higgs (2)
- Hirnhautentzündung (2)
- Image-guidance (2)
- Integrated network analysis (2)
- JES uncertainty (2)
- Keldysh formalism (2)
- Klimaänderung (2)
- LHC (2)
- Landnutzung (2)
- Learning (2)
- Leishmania major (2)
- Lernen (2)
- MAP-Kinase (2)
- MC event generator (2)
- MODIS (2)
- MYC (2)
- Makrophage (2)
- Malaria (2)
- Meningitis (2)
- Metastase (2)
- Modell (2)
- Molekulargenetik (2)
- Monte Carlo (2)
- NPY (2)
- Netzwerkanalyse (2)
- Neurogenese (2)
- New Zealand (2)
- Newton-Verfahren (2)
- Numerisches Verfahren (2)
- Onkolyse (2)
- Optimale Kontrolle (2)
- Optische Spektroskopie (2)
- P300 (2)
- Photoelektronenspektroskopie (2)
- Pore (2)
- Porenbildung (2)
- Pp Collision (2)
- Proliferation (2)
- RNA-seq (2)
- Radiosurgery (2)
- Raf kinases (2)
- Rastertunnelmikroskop (2)
- Renormierungsgruppe (2)
- SMN (2)
- Serotonin (2)
- Simulation (2)
- Sinnesphysiologie (2)
- Spektroskopie (2)
- Strahlentherapie (2)
- Strahlungstransport (2)
- Supraleiter (2)
- Supraleitung (2)
- Systembiologie (2)
- T = 100 K (2)
- T cell (2)
- Thrombozyt (2)
- Toxin (2)
- Transkriptionsfaktor (2)
- West Africa (2)
- Zeitreihenanalyse (2)
- Zeitrichtung (2)
- ablation (2)
- acceptance time efficiency (2)
- acute kidney injury (2)
- adalimumab (2)
- african trypanosomes (2)
- angiogenesis (2)
- anti-k jet (2)
- antirheumatic agents (2)
- architecture (2)
- astrocytes (2)
- basal ganglia (2)
- biomarkers (2)
- blood pressure (2)
- blood-brain barrier (2)
- breast cancer (2)
- c-myc (2)
- calorimeter (2)
- cancer cells (2)
- carcinoma (2)
- cerebral ischemia (2)
- chemotherapy (2)
- ciliary neurotrophic factor (2)
- climate change (2)
- closed head injury (2)
- coagulation (2)
- comparative genomic hybridization (2)
- decision making (2)
- deficient mice (2)
- degeneration (2)
- dementia (2)
- dendritic cells (2)
- dependent protein-kinase (2)
- depression (2)
- disease progression (2)
- dispersal (2)
- diversity (2)
- domain (2)
- dopamine (2)
- down regulation (2)
- drug (2)
- endocannabinoid (2)
- endophenotype (2)
- endothelial cells (2)
- enterica serovar typhimurium (2)
- environment (2)
- evolution (2)
- experimental autoimmune encephalomyelitis (2)
- fake lepton (2)
- films (2)
- focal cerebral-ischemia (2)
- follow up (2)
- follow-up (2)
- functional characterization (2)
- giant ventral hernia (2)
- graphene (2)
- growth (2)
- ideomotor theory (2)
- immunoreactive neurons (2)
- in vivo (2)
- in-vitro (2)
- inflammation (2)
- injury (2)
- insect immunity (2)
- jet channel (2)
- jet reconstruction efficiency (2)
- jet transverse momentum (2)
- kinase (2)
- laparostomy (2)
- lines (2)
- linkage (2)
- living cells (2)
- localization (2)
- magnetic resonance (2)
- malignant melanoma (2)
- mass spectrometry (2)
- mechanisms (2)
- melanogaster (2)
- metastasis (2)
- microenvironment (2)
- microglia (2)
- migration (2)
- multi-jet background (2)
- muon channel (2)
- mutation (2)
- mutations (2)
- myelin (2)
- myocardial infarction (2)
- myocardial-infarction (2)
- neurons (2)
- nude-mice (2)
- olfactory memory (2)
- oncolysis (2)
- open abdomen (2)
- ovarian cancer (2)
- partial decay width (2)
- pathway (2)
- peptide vaccination (2)
- perception (2)
- perspectives (2)
- phosphorylation (2)
- prevalence (2)
- primary vertex (2)
- proteasome (2)
- randomized controlled trial (2)
- recognition (2)
- regression analysis (2)
- resolution (2)
- responses (2)
- rheumatoid arthritis (2)
- ribosomal RNA (2)
- sample (2)
- schizophrenia (2)
- senescence (2)
- signal cross section (2)
- simulated signal event (2)
- single top event (2)
- single top production (2)
- single top quark (2)
- single top quark production (2)
- sleep (2)
- sleep disorders (2)
- smooth muscle cells (2)
- speech perception (2)
- stability (2)
- staphylococcus aureus (2)
- startle reflex (2)
- surface (2)
- susceptibility gene (2)
- synthetic mesh (2)
- tissue (2)
- tissue engineering (2)
- tolerance (2)
- top quark decay (2)
- trabeculectomy (2)
- transcription (2)
- transmission (2)
- traumatic brain injury (2)
- treatment outcome (2)
- triple in situ hybridization (2)
- tumor (2)
- vaccine (2)
- vacuum conditioning (2)
- variability (2)
- variants (2)
- virulence (2)
- visible cross section (2)
- wR factor = 0.068 (2)
- . (1)
- 1/N expansion (1)
- 14.7K (1)
- 19F-MR (1)
- 1ES 1011+496 (1)
- 1ES 2344+514 (1)
- 1p13.3 (1)
- 1q21 (1)
- 2',7'-dichlorofluorescin (1)
- 2,5-diketopiperazines (1)
- 5-HT transporter (1)
- 68Ga-DOTATATE (1)
- 7000 GeV-cms (1)
- 7q11.2 (1)
- A-type lamins (1)
- ACC deaminase (1)
- AGT (1)
- ALK-1 (1)
- ALMT (1)
- ALS (1)
- AMD (1)
- AMP (1)
- AMPK (1)
- ARF (1)
- ATLAS <Teilchendetektor> (1)
- ATLAS detector (1)
- Abl (1)
- Acetylneuraminsäure <N-> (1)
- Actin (1)
- Actin nucleation (1)
- Actin-bindende Proteine (1)
- Activation induced cell death/AICD (1)
- AdS-CFT-Korrespondenz (1)
- AdS/CFT (1)
- Adiabatic Theorem of quantum mechanics (1)
- Advanced snowmelt (1)
- Ag(111) (1)
- Aharonov-Bohm effect (1)
- Aharonov-Bohm-Effekt (1)
- Ako na Uche (1)
- Aktinnukleation (1)
- Alcohol (1)
- Aldehyde (1)
- Alkohol (1)
- Allergie (1)
- Allergy (1)
- Alliances (1)
- Alps (1)
- Altern (1)
- Alternative Conflict Resolutions (1)
- Alveolar Echinococcosis (1)
- Alveoläre Echinokokkose (1)
- Alzheimer Dementia (1)
- Alzheimer's disease (1)
- Alzheimer-Krankheit (1)
- Alzheimer’s disease (1)
- Amazonia (1)
- Ambulantes Assessment (1)
- Ambulatory Assessment (1)
- Ameisen (1)
- Amyloid <beta-> (1)
- Ancistrocladus (1)
- Anergy (1)
- Aneuploidie (1)
- Angeregter Zustand (1)
- Animal Spirits (1)
- Animal models (1)
- Anoikis (1)
- Anthocyane (1)
- Anthrax toxin (1)
- Antibody (1)
- Anticipation (1)
- Antigen CD28 (1)
- Antikörper (1)
- Antimicrobial activity (1)
- Antizipation (1)
- Anämie (1)
- Arabidopsis (1)
- Araneae (1)
- Areal (1)
- Argumentation (1)
- Artverbreitungsmodellierung (1)
- Arzneimittel (1)
- Aspergillus fumigatus (1)
- Aspergillus niger (1)
- Astrozyt (1)
- Atherosclerotic plaque (1)
- Attentional performance (1)
- Aufmerksamkeits-Defizit-Syndrom (1)
- Ausfallsicheres System (1)
- Ausfallsicherheit (1)
- Autoaggressionskrankheit (1)
- AuxRE (1)
- Auxin-regulated transcription (1)
- B cell (1)
- B cells (1)
- B neisseria meningitidis (1)
- B-tagged jet (1)
- BBCH (1)
- BK virus (1)
- BL Lacertae (1)
- BL-Lacertae-Objekt (1)
- BRAF (1)
- BRCA1 (1)
- BRCA1 positive (1)
- BRCA1/2 negative (1)
- BRCA2 positive (1)
- Bacillus anthracis (1)
- Bacillus megaterium (1)
- Bacterial Toxins (1)
- Bacterial meningitis (1)
- Bakterielle Hirnhautentzündung (1)
- Bakterien (1)
- Basin-Hopping (1)
- Bayesian Estimation (1)
- Berry Phase (1)
- Betriebssystem (1)
- Beweistheorie (1)
- Bildgebendes Verfahren (1)
- Biochemistry (1)
- Biodiversität (1)
- Biogenese (1)
- Biokonjugate (1)
- Biolabelling (1)
- Biologische Aktivität (1)
- Biomarker (1)
- Bioorganometallchemie (1)
- Bioorthogonal (1)
- Biotechnologie (1)
- Biotechnologische Industrie (1)
- Biotechnology (1)
- Black lipid bilayer (1)
- Blazar (1)
- Bloch-Siegert (1)
- Blochmannia (1)
- Blumeria graminis (1)
- Blut-Hirn-Schranke (1)
- Blutbildendes Gewebe (1)
- Blutplättchen (1)
- Blutstammzelle (1)
- Bor (1)
- Boracumulen (1)
- Boracumulene (1)
- Boraheterocycles (1)
- Borheterocyclen (1)
- Boron (1)
- Borylene (1)
- Borylene complexes (1)
- Borylenkomplexe (1)
- Botanik (1)
- Bowen’s disease, periungual (1)
- Box-Jenkins-Verfahren (1)
- Box–Jenkins Program (1)
- Brain edema (1)
- Brain ischemia (1)
- Bre (1)
- Bre-knockout (1)
- Brugia Malayi (1)
- Bullous pemphigoid (1)
- Burkholderia (1)
- Burkholderia pseudomallei (1)
- C-13 NMR (1)
- C-MYC (1)
- C-reactive protein (1)
- C57BL/KALWRIJ mouse (1)
- C9orf72 (1)
- CC2 (1)
- CCL2 (MCP-1) (1)
- CD28 antigen (1)
- CD28-Superagonist (1)
- CD28-superagonist (1)
- CD30 (1)
- CD4(+) (1)
- CD4(+) T-cells (1)
- CD95 (1)
- CENP-A (1)
- CERN LHC Coll (1)
- CIS+ (1)
- CMR (1)
- COMT VAL(158)MET polymorphism (1)
- COPD diagnosis (1)
- CORM (1)
- CPP Peptide (1)
- CPP-peptide (1)
- CSE4, CENP-A (1)
- CSF (1)
- CSF-1 Rezeptor (1)
- CSF-1 receptor (1)
- CT-INT (1)
- CXCL8 (IL-8) (1)
- Caco-2 (1)
- Calcineurin (1)
- Calciumtransport (1)
- Camponotus (1)
- Camponotus floridanus (1)
- Cancer (1)
- Carcinogenität (1)
- Cardiovascular risk factors (1)
- Caspase 12 (1)
- Cerebral blood flow (1)
- Cerebral vasospasm (1)
- Chaos (1)
- Chaostheorie (1)
- Chaotisches System (1)
- Charcot-Marie-Tooth (1)
- Charcot-Marie-Tooth disease (1)
- Charcot–Marie–Tooth disease (1)
- Chemotherapie (1)
- Chemotherapy (1)
- Chondrozyten (1)
- Circadian Rhythms (1)
- Circadiane Rhythmik (1)
- Cis-elements (1)
- Cisterna magna (1)
- City Planning in the USA (1)
- Click-Chemie (1)
- Climate change (1)
- Cluster-Entwicklung (1)
- Cobaltate (1)
- Cobaltates (1)
- Coexpression (1)
- Cognitive (1)
- Coherent 2D Spectroscopy (1)
- Colloids (1)
- Combination (1)
- Commercial preparations (1)
- Compressed Sensig (1)
- Computational chemistry (1)
- Computersimulation (1)
- Cone-beam CT (1)
- Conjugate gradient method (1)
- Contaminants (1)
- Coronary artery bypass graft (1)
- Cortison (1)
- Cryolesion (1)
- Crystalloids (1)
- Cuprates (1)
- Cushings syndrome (1)
- Cyclooctine (1)
- Cyclooctyne (1)
- Cymantren (1)
- Cystic fibrosis (1)
- Cytotoxizität (1)
- DCA (1)
- DNA Methylation (1)
- DNA Reparatur (1)
- DNA repeat expansion (1)
- DNA replication (1)
- DNA-binding vesicles (1)
- DNS-Reparatur (1)
- DOT1 (1)
- DRD2 (1)
- Danish hernia database (1)
- Darmkrebs (1)
- Database (1)
- Datenbanksystem (1)
- Decision-making (1)
- Defensine (1)
- Delay-Differential Equations (1)
- Delayed snowmelt (1)
- Demenz (1)
- Dendrimer (1)
- Depression (1)
- Design (1)
- Diabetes (1)
- Diabetes Typ 1 (1)
- Diarylethen (1)
- Diarylethene (1)
- Diarylethylene (1)
- Dickblattgewächse (1)
- Dielektrikum (1)
- Dimension 2 (1)
- Dimeric Naphthylisoquinoline Alkaloids (1)
- Dimermethode (1)
- Direkte numerische Simulation (1)
- Diskursanalyse (1)
- Dissipatives System (1)
- Disulfidbrücken (1)
- Domänenprotein (1)
- Dopamin (1)
- Double hemorrhage model (1)
- Drahtloses Sensorsystem (1)
- Dreiecksgitter (1)
- Driver Assistance System (1)
- Driving (1)
- Drogen (1)
- Duftintensität (1)
- Duftstoff (1)
- Dynamic Geometry Environment (1)
- Dynamic Memory Management (1)
- Dynamische Geometriesysteme (1)
- Dynamische Speicherverwaltung (1)
- Dynamisches System (1)
- E. coli Nissle 1917 (1)
- E3 14.7-kilodalton protein (1)
- E3 ubiquitin ligase (1)
- EBRT (1)
- ECG-recording (1)
- ECORN-CF Projekt (1)
- EHS classification (1)
- EMG (1)
- EORTC-BN20 (1)
- EORTC-QLQ-C15-PAL (1)
- EP Procedures (1)
- ERK signaling (1)
- ERP-BCI (1)
- ERPS (1)
- ETR (1)
- Echinococcus multilocularis (1)
- Echtzeitsystem (1)
- Ecological Momentary Assessment (1)
- Eierstockkrebs (1)
- Eindrucksbildung (1)
- Eingebettetes System (1)
- Einzelhandel (1)
- Eisen-basierte Supraleiter (1)
- Electromagnon (1)
- Electronic diary (1)
- Electrospinning (1)
- Elektrizitätserzeugung (1)
- Elektromagnon (1)
- Elektromigration (1)
- Elektronenflüssigkeit (1)
- Elektronengas (1)
- Elektronenstrahllithographie (1)
- Elektronentransfer (1)
- Elektronisches Tagebuch (1)
- Elektrostatisches Verspinnen (1)
- Elementarteilchenphysik (1)
- Embedded Systems (1)
- Embryo (1)
- Embryonalentwicklung (1)
- Emery-Dreifuss muscular dystrophy (1)
- Encephalomyelitis (1)
- Endogenous Glucocorticoids (1)
- Energie (1)
- Energielandschaft (1)
- Entscheidung (1)
- Entscheidungsprozess (1)
- Entzündung (1)
- Epigenese (1)
- Epigenetic (1)
- Epigenetik (1)
- Epitaxieschicht (1)
- Erysiphe graminis (1)
- Erythropoietin (1)
- Escherichia coli (1)
- European beech (1)
- European countries (1)
- European experience (1)
- Evakuierung (1)
- Excitotoxicity (1)
- Experimental brain trauma (1)
- Experimentellen Autoimmun-Enzephalomyelitis (1)
- Extended field irradiation (1)
- Extremwerttheorie (1)
- Extremwetterereignisse (1)
- Exziton (1)
- FAS (1)
- FAS-II (1)
- FGF (1)
- FGF Signaling (1)
- FIR-Spektroskopie (1)
- FMRI (1)
- FXII (1)
- FabI (1)
- FabV (1)
- Fabry disease (1)
- Factor XII (1)
- Fahren (1)
- Fahrerassistenz (1)
- Faktor XII (1)
- Fanconi Anemia (1)
- Fanconi Anämie (1)
- Fanconi-anemia subtype (1)
- Farbstoff (1)
- Fe3O4 (1)
- Femtosekundenspektroskopie (1)
- Fermionensystem (1)
- Fernerkundung (1)
- Fernwartung (1)
- Festkörperphysik (1)
- Festkörpertheorie (1)
- Fettsäurebiosynthese (1)
- Fettsäurestoffwechsel (1)
- Fibroblasten (1)
- Fibroblastenwachstumsfaktor (1)
- Flowering (1)
- Fluency (1)
- Fluidnetzwerk (1)
- Fluor-19 (1)
- Fluoreszenz (1)
- Fluoreszenzmikrosopie (1)
- Foamy virus (1)
- Follicular lymphoma (1)
- Fontan’s Operation (1)
- Forschung und Entwicklung (1)
- Fotovoltaik (1)
- Frabin/Fgd4 (1)
- Frame-based (1)
- Frame-less (1)
- Freies Molekül (1)
- Frequency Domain (1)
- Front Collision Warning (1)
- Frontkollisionswarnung (1)
- Fumonisin B1 (1)
- Fumonisine (1)
- Functional interaction (1)
- Functional module search (1)
- Functional modules (1)
- Funktionelle Bildgebung (1)
- Funktionelle Modulsuche (1)
- G protein coupled receptor (1)
- G-Protein gekoppelte Rezeptoren (1)
- GABA (1)
- GABA A Receptors (1)
- GABA A Rezeptoren (1)
- GABA(A) receptors (1)
- GABAA-Rezeptor (1)
- GABP (1)
- GATA4 (1)
- GMSB model (1)
- GO1 (1)
- GOLD (1)
- GRN (1)
- GagPol fusion protein (1)
- Gametozyt (1)
- Gammaastronomie (1)
- Garcinia biflavonoids (1)
- Gaudium et Spes (1)
- Gedächtnis (1)
- Geldpolitik (1)
- Gen (1)
- Gen Umweltinteraktion (1)
- Gen notch (1)
- Genomische Bildgebung (1)
- Genotoxizität (1)
- Genregulation (1)
- Geoinformationssystem (1)
- Gephyrin (1)
- Gerinnungsfaktor XII (1)
- Germanium (1)
- Gerste (1)
- Geschmack (1)
- Geschmackssinn (1)
- Gesundheitswesen (1)
- Gewebe (1)
- Geweberegeneration (1)
- Gliom (1)
- Glioma (1)
- Globale Optimierung (1)
- Glucosetransportproteine (1)
- GlyRs (1)
- Glycine Receptors (1)
- Glycoengineering (1)
- Glycosyltransferase (1)
- Glyzin Rezeptoren (1)
- Glyzinrezeptor (1)
- Gold (1)
- Graft-versus-host disease (1)
- Graphene (1)
- Grassmann Manifold (1)
- Grassmann-Mannigfaltigkeit (1)
- Guanin Nukleotid Austauschfaktor (1)
- Guaninnucleotid-Austauschfaktoren (1)
- Göttingen (1)
- H.264 SVC (1)
- H.264/SVC (1)
- HBD2 (1)
- HBL (1)
- HBO (1)
- HD5 (1)
- HES (1)
- HIV-1; subtype C; proviral plasmid; viral replication; resistance assays; Vpu; CD317; CD4 (1)
- HLA (1)
- HMI (1)
- HPLC-MS/MS method (1)
- HRAS (1)
- HaCaT cells (1)
- Hadron-Hadron Scattering (1)
- Halbleiterlaser (1)
- Halbleiteroberfläche (1)
- Handelsgeographie (1)
- Hautkrebs (1)
- Helicobacterpylori (1)
- Helminths (1)
- Heparin (1)
- Hepatitis C infection (1)
- Hepatotoxizität (1)
- Herbivor-Parasitoid Interaktion (1)
- Herz (1)
- Herzentwicklung (1)
- Herzhypertrophie (1)
- Heterostrukturen (1)
- Hfq (1)
- HgTe (1)
- Hidden Markov Model (1)
- Higgs boson signal (1)
- Hilfe-System (1)
- Hochauflösendes Verfahren (1)
- Hochtemperatursupraleitung (1)
- Holliday junction reolvass (1)
- Hormone Receptor Signaling (1)
- Hospitalization (1)
- Housing (1)
- Human papillomavirus (1)
- Humorale Immunität (1)
- II type-2 receptor (1)
- IL-12 production (1)
- IL-17 (1)
- IL-4 (1)
- IL-4 Rezeptor alpha (1)
- IL-4 receptor alpha chain (1)
- IL28B (1)
- IMpACT (1)
- IVF-methods (1)
- Image Registration (1)
- Imatinib (1)
- Imd pathway (1)
- Immobilienmarkt (1)
- Immunisierung (1)
- Immunmodulation (1)
- Immunoadsorption (1)
- Immunoapheresis (1)
- Immunologie (1)
- Immunomodulation (1)
- Immunsystem (1)
- Impfstoff (1)
- Impfung (1)
- Impulslaserbeschichten (1)
- Incommensurate spin structure (1)
- Infectious disease (1)
- Inferior vena cava (1)
- Inflammation (1)
- Influenza (1)
- Informationsverarbeitung (1)
- Inkommensurable Zykloide (1)
- Innovation (1)
- Insulin (1)
- Insulinrezeptor (1)
- Insulinsignalweg (1)
- Integrase (1)
- Integrated Knowledgebase (1)
- Integrierte Datenbank (1)
- Inter-observer variability (1)
- Interactive Help System (1)
- Interaktion (1)
- Interferon <gamma-> (1)
- Interleukin 12 (1)
- Interleukin 6 (1)
- Internationaler Konflikt (1)
- Intrazelluläre Symbiose (1)
- Invasion (1)
- Inverse Probleme (1)
- JES (1)
- Japanese population (1)
- Japankärpfling (1)
- KATP channel (1)
- Kapazität (1)
- Kardial Hypertrophy (1)
- Katholische Kirche (1)
- Keldysh Formalismus (1)
- Keramischer Supraleiter (1)
- Kernspintomografie (1)
- Kerntransport (1)
- Kirche (1)
- Kleinkern (1)
- Klima (1)
- Klimamodellierung (1)
- Klimaschutz (1)
- Klimaschutzkonzept (1)
- Klimaschwankung (1)
- Knochendichte (1)
- Knochenstoffwechsel (1)
- Knockout-Maus (1)
- Knorpelzelle (1)
- Knowledge Management System (1)
- Knowledge-based System (1)
- Kognitive Kontrolle (1)
- Kohärente 2D Spektroskopie (1)
- Kohärente Optik (1)
- Kombinationstherapie (1)
- Konfliktlösung (1)
- Konforme Feldtheorie (1)
- Konjugate (1)
- Konjugierte-Gradienten-Methode (1)
- Koran (1)
- Korruption (1)
- Kraftfeld-Rechnung (1)
- Krebs <Medizin> (1)
- Kreditmarkt (1)
- Kristallwachstum (1)
- Kulturelle Identität <Motiv> (1)
- Kuprate (1)
- Kutikularwachs (1)
- Körper <Motiv> (1)
- L cells (1)
- LIFR (1)
- LMNA mutations (1)
- LPHN3 (1)
- LTD (1)
- LaAlO3 (1)
- LaVO3 (1)
- Ladungstransfer (1)
- Lamto Reserve (1)
- Land use (1)
- Landkreis (1)
- Landschaft (1)
- Large Hadron Collider (1)
- Leber (1)
- Lebertoxizität (1)
- Leishmania (1)
- Leukaemia-inhibitory factor (1)
- Levothyroxine (1)
- Lin9 (1)
- Lipidmembran (1)
- Ljapunov-Funktion (1)
- Ljapunov-Stabilitätstheorie (1)
- Localization (1)
- Lokalisation (1)
- Lung Cancer metastasis (1)
- Lung cancer (1)
- Luttinger liquide (1)
- Luttinger-Flüssigkeit (1)
- Lyapunov Funktion (1)
- Lyapunov functions (1)
- MAGIC-Teleskop (1)
- MAP3K4 (1)
- MBE (1)
- MC expectation (1)
- MC program (1)
- MCPH1 (1)
- MK801 (1)
- MR guidance (1)
- MRSA (1)
- MS (1)
- MYB (1)
- Macrophage (1)
- Magnetfeld (1)
- Magnetischer Sensor (1)
- Magnetoelectric effect (1)
- Magnetoelektrischer Effekt (1)
- Magnon (1)
- Majorana Zustände (1)
- Makrophagen (1)
- Management System (1)
- Management-Systeme (1)
- Manganate (1)
- Manganverbindungen (1)
- Marker (1)
- Martensit (1)
- Mass Isotopomers Distribution Analysis (1)
- Massen-Isotopomer Verteilungs-Analyse (1)
- Mast cells (1)
- Mastzelle (1)
- Mathematikunterricht (1)
- Mausmodell (1)
- Maximum Entropy Algorithmus (1)
- Maximum Entropy algorithm (1)
- Maße für Quantenverschränkung (1)
- Medienanalyse (1)
- Medienkommunikation (1)
- Mehrpfadübertragung (1)
- Mehrschichtnetze (1)
- Mehrschichtsystem (1)
- Mehrskalenmodell (1)
- Melanophor (1)
- Melatonin (1)
- Memory (1)
- Meningioma (1)
- Merocyanin (1)
- Merocyanine (1)
- Mesh Augmentation (1)
- Messenger-RNS (1)
- Metabolic Flux Analysis (1)
- Metabolic pathways (1)
- Metabolic profiles (1)
- Metabolische Flux-Analyse (1)
- Metall-Isolator-Phasenumwandlung (1)
- Metallorganische Verbindungen (1)
- Metastasierung (1)
- Methodenentwicklung (1)
- Methylierung (1)
- Methylphenidat (1)
- Mexico (1)
- Mexiko (1)
- Mice (1)
- Michael addition (1)
- Michael-Addition (1)
- Micro-Hall Magnetometry (1)
- Micro-SQUID (1)
- Microarray (1)
- Microcirculation (1)
- Micromonospora (1)
- Mikro-SQUID (1)
- Mikrohallmagnetometrie (1)
- Milnesium tardigradum (1)
- Minischwein (1)
- Mitose (1)
- Mittelmeer (1)
- Mittelmeerraum (1)
- Miz1 (1)
- Mobile technology (1)
- Mobiler Roboter (1)
- Molecular probes (1)
- Molekularelektronik (1)
- Molekularstrahlepitaxie (1)
- Molybdän (1)
- Molybdäncarbonyle (1)
- Monetary Policy (1)
- Monetary Union (1)
- Monoklonaler Antikoerper (1)
- Monte Carlo methods (1)
- Monte Carlo simulation (1)
- Motoneuron (1)
- Motor cortex (1)
- Motor plasticity (1)
- Mott-Schottky Analyse (1)
- Multi-Layer (1)
- Multiferroikum (1)
- Multipath Transmission (1)
- Multiple sclerosis (1)
- Multiwellenlängen (1)
- Muskelkraft (1)
- Mutagenität (1)
- Mycobacterium caprae (1)
- Mycobacterium tuberculosis complex (1)
- Mycoplasma (1)
- Myelin (1)
- Myeloblast (1)
- Myeloide Suppressorzellen (1)
- Mykotoxin (1)
- Myon (1)
- N-Myc down regulated gene 1 (1)
- N-RAS (1)
- N170 (1)
- NA/I symporter (1)
- NADPH oxidase (1)
- NADPH oxidases (NOX) (1)
- NCAM1 (1)
- NDVI (1)
- NF-kappa-B (1)
- NF-κB (1)
- NFATc (1)
- NFATc1/αA (1)
- NI(111) (1)
- NIH-3T3 (1)
- NMDA-Antagonist (1)
- NMDA-Rezeptor (1)
- NMDAR (1)
- NMO-IGG (1)
- NMR-Bildgebung (1)
- NMR-Tomographie (1)
- NP-hardness (1)
- NRPS (1)
- Nahfeldoptik (1)
- Nail unit (1)
- Nanodraht (1)
- Nanoelektromechanik (1)
- Nanoelektromechanische Systeme (1)
- Nanofaser (1)
- Nanooptic (1)
- Naphthochinonen (1)
- Naphthoquinones (1)
- Nephrotoxizität (1)
- Nervendegeneration (1)
- Nervennetz (1)
- Nervenzelle (1)
- Network Analysis (1)
- Networks (1)
- Netzwerk (1)
- Netzwerkalgorithmen (1)
- Neurobiologie (1)
- Neurodegeneration (1)
- Neuropathie (1)
- Neuropsychologie (1)
- Neurotransmitter Receptors (1)
- Neurotransmitter Rezeptoren (1)
- Neurotransmitter-Rezeptor (1)
- Neuseeland (1)
- New mexico (1)
- Newton Methods (1)
- Newton method (1)
- Newtonverfahren (1)
- Next generation sequencing (1)
- Nicht-Transparente Medien (1)
- Nicht-kleinzelliges Bronchialkarzinom (1)
- Nichtkonvexe Optimierung (1)
- Nichtlineare Kontrolltheorie (1)
- Nichtlineares System (1)
- Nichtlineares dynamisches System (1)
- Niederschlag (1)
- Nigeria (1)
- Niveaustufen des Beweises (1)
- Non-Small Cell Lung Cancer (1)
- Non-transparency (1)
- Nonlinear Dynamics (1)
- Notfall (1)
- Nothotaxa (1)
- Nukleäre Hormonrezeptoren (1)
- OIS (1)
- OPUS (1)
- OSMR (1)
- Oberflächenfunktionalisierung (1)
- Oberflächenphysik (1)
- Oberflächenplasmonresonanz (1)
- Oberflächenproteine der Sexualstadien (1)
- Odour Intensity (1)
- Olfaction (1)
- Olfactory (1)
- Oligofructoside (1)
- Oncostatin M (1)
- Onkogen (1)
- Optimierung (1)
- Optimization on Lie Groups (1)
- Organische Solarzelle (1)
- Organometall-Komplexe (1)
- Ovarialkarzinom (1)
- Ovarian Cancer (1)
- Oxid (1)
- Oxidativer Stress (1)
- Oxide (1)
- O–I 1 fluorescence rise (1)
- P15(INK4B) (1)
- P21 (1)
- P300-Speller (1)
- P67(PHOX) (1)
- PALM (1)
- PAR (1)
- PARM (1)
- PBPK/PBTK model (1)
- PDF set (1)
- PDI (1)
- PG neurons (1)
- PIK3CA mutations (1)
- PLD (1)
- POZ domain (1)
- PPAR-gamme (1)
- PRMT5 (1)
- PRRT (1)
- PTPN22 (1)
- Pain (1)
- Papier-Solarzelle (1)
- Parasit (1)
- Parathormon (1)
- Parkinsons disease (1)
- Parkinson’s disease (1)
- Path Computation Element (1)
- Patulin (1)
- Pediatric (1)
- Peptide receptor radionuclide therapy (1)
- Perception (1)
- Perforine (1)
- Performance Modeling (1)
- Persistenz (1)
- Person Perception (1)
- Perylenbisimid (1)
- Perylene bisimide (1)
- Pfadberechnungselement (1)
- Phage Display (1)
- Phase II trial (1)
- Phasenumwandlung (1)
- Phosphoproteomic analysis (1)
- Photochemie (1)
- Photochemistry (1)
- Photochromie (1)
- Photorezeption (1)
- Photostrom (1)
- Phylogenie (1)
- Physikalische Eigenschaft (1)
- Physikalische Zeit (1)
- Physiologie (1)
- Physiology (1)
- Planung (1)
- Plasmodium falciparum (1)
- Platelet activating Factor (1)
- Platelets (1)
- Plättchennetzwerk (1)
- Plättchenphosphoproteom (1)
- Pnictide (1)
- Polarisationspulsformung (1)
- Polarisiertes Licht (1)
- Polychromophores System (1)
- Polymere (1)
- Polyomaviren (1)
- Polyomavirus JC (1)
- Pontryagin Maximum Principle (1)
- Pontryagin Maximum Prinzip (1)
- Populorum Progressio (1)
- Pore formation (1)
- Pore-formation (1)
- Porifera (1)
- Postcolonial literature (1)
- Postkoloniale Literatur (1)
- Pragmatik (1)
- Predictors (1)
- Prednisolon (1)
- Preemptive-strike (1)
- Prefrontal cortex (1)
- Prevalence (1)
- Probiotic (1)
- Probiotikum (1)
- Proof (1)
- Prostatakrebs (1)
- Protein Disulfid Isomerase (1)
- Protein p53 (1)
- Proteinfaltung (1)
- Proteinkinasen (1)
- Proteinsynthese (1)
- Proteomanalyse (1)
- Proteome (1)
- Proving Level (1)
- Prozessierung (1)
- Prädiktor (1)
- Präfrontaler Kortex (1)
- Präparative organische Chemie (1)
- Prävalenz (1)
- Psychiatrie (1)
- Psychologische Diagnostik (1)
- Psychologische Sicherheitsforschung (1)
- Psychology (1)
- Ptpn22 (1)
- QCD (1)
- QCD background (1)
- QDTI (1)
- QMC (1)
- QUAC (1)
- QoE (1)
- Quality-of-Experience (1)
- Quanten Spin Hall Effekt (1)
- Quanten-Hall-Effekt (1)
- Quantenchemie (1)
- Quantenfeldtheorie (1)
- Quantenkontrolle (1)
- Quantenmechanisches System (1)
- Quantenspinsystem (1)
- Quantum dynamics (1)
- Quantum spin Hall (1)
- Quecksilbertellurid (1)
- Quran (1)
- R factor = 0.018 (1)
- R factor = 0.025 (1)
- R factor = 0.027 (1)
- R-715 (1)
- RAD51C (1)
- REST (1)
- RNA (1)
- RNA denaturation (1)
- RNA sequencing (1)
- RNA structure (1)
- RNA synthesis (1)
- RNA-polymerase-II (1)
- Radioastronomie (1)
- Radiotherapy (1)
- Rare earth manganites (1)
- Rashba effect (1)
- Rashba-Effekt (1)
- Rat (1)
- Ratte (1)
- Rauschgift (1)
- Real-Time Operating Systems (1)
- Receptor Anchoring (1)
- Receptor Preference (1)
- Recombinant defensins (1)
- Regeneration (1)
- Registrierung <Bildverarbeitung> (1)
- Regulation of protease activity (1)
- Regulatorischer T-Lymphozyt (1)
- Regulatory T-cell (1)
- Rekombinante DNS (1)
- Rekombination (1)
- Rekonstruktion (1)
- Remote sensing (1)
- Renal cell carcinoma (1)
- Repression <Genetik> (1)
- Resilience (1)
- Resonanzstreuung (1)
- Resource Management (1)
- Respiration correlated imaging (1)
- Ressourcenallokation (1)
- Ressourcenmanagement (1)
- Resveratrol (1)
- Rezeptor Verankerung (1)
- Rho (1)
- Rho-GTPase Cdc42 (1)
- Ribosomale RNA (1)
- Riemannian optimization (1)
- Riemannsche Geometrie (1)
- Riemannsche Optimierung (1)
- Ring closing metathesis (1)
- Ringschlussmetathese (1)
- Risikoindex (1)
- Ruthenate (1)
- Röntgen-Photoelektronenspektroskopie (1)
- Röntgenastronomie (1)
- Rüsselkäfer (1)
- SAS <Programm> (1)
- SCF (1)
- SER/THR kinase (1)
- SGLT1 (1)
- SIRP-alpha (1)
- SKP1 (1)
- SLAC/SLAH (1)
- SLX4 (1)
- SM Background (1)
- SM proteins (1)
- SOD1 mutations (1)
- SST (1)
- ST1797 (1)
- ST88 (1)
- STAIR (1)
- SUSY breaking scale (1)
- SVR (1)
- SWI/SNF (1)
- SacB (1)
- Sahel (1)
- Salmonella (1)
- Salmonella enterica (1)
- Salmonella typhimurium (1)
- Salmonella-containing vacuole (1)
- Sandwich-Verbindungen (1)
- Savanna (1)
- Savannas (1)
- Schilddrüse (1)
- Schilddrüsenhormontherapie (1)
- Schlaganfall (1)
- Schwann cells (1)
- Scleroderma (1)
- Secondary traumatic brain damage (1)
- Secretion (1)
- Sedum rupestre L. subsp. erectum ‘t Hart (1)
- Selbstorganisation (1)
- Selbstverteidigung (1)
- Selbstverteidigung <Völkerrecht> (1)
- Self-Trapping (1)
- Self-defense (1)
- Seltene Erden (1)
- Seltenerdverbindungen (1)
- Semiconductor Lasers (1)
- Seneszenz (1)
- Sensory (1)
- Sepsis (1)
- Sequenz (1)
- Serengeti (1)
- Serotonintransporter (1)
- Sexuelle Entwicklung (1)
- Short dsRNA oligonucleotides (1)
- Sialic acids (1)
- Sialinsäuren (1)
- Signalkette (1)
- Signaltransduktion (1)
- Silicium (1)
- Similarity (1)
- Simkania Negevensis (1)
- Single-Molecule Transistor (1)
- Small RNA (1)
- Small nuclear RNP (1)
- Smartphone (1)
- Social Influence (1)
- Software (1)
- Somatostatin receptor (1)
- South Africa (1)
- Sozialer Einfluss (1)
- Sozialethik (1)
- Soziallehre (1)
- Sozialpsychologie (1)
- Species distribution modeling (1)
- Spectrofluorimetry (1)
- Speicher <Informatik> (1)
- Spezialisierung (1)
- Spin-Bahn-Wechselwirkung (1)
- Spinal metastasis (1)
- Spir (1)
- Spitzwegerich (1)
- Stabilität (1)
- Stadtplanung (1)
- Stammzelle (1)
- Standardmodell (1)
- Standortpolitik (1)
- Stat5 (1)
- State-Space Models (1)
- Stereotactic (1)
- Stereotactic body radiotherapy (1)
- Stereotype (1)
- Stereotypes (1)
- Steuerbarkeit (1)
- Stim (1)
- Stochastic Algorithms (1)
- Stochastische Optimierung (1)
- Stoffwechsel (1)
- Strassentunnel (1)
- Streptococcus pneumoniae (1)
- Stressreaktion (1)
- Stringtheorie (1)
- Strong correlations (1)
- Struktur (1)
- Struktur-basiertes Wirkstoff Design (1)
- Subarachnoid (1)
- Subarachnoid hemorrhage (1)
- Suc1 (1)
- Sumo (1)
- Sumoylierung (1)
- Superconductivity (1)
- Suppressorzelle (1)
- Surface plasmons (1)
- Synapse (1)
- Synchronisierung (1)
- Synchronization (1)
- Synthesis (1)
- Systems Biology (1)
- T = 173 K (1)
- T = 199 K (1)
- T cell development (1)
- T cell homing (1)
- T cell receptor (1)
- T helper cell (1)
- T(H)17 cells (1)
- T-Lymphozyten-Rezeptor (1)
- T-PA (1)
- T-Zellhoming (1)
- T-antigen (1)
- T-cell reactivity (1)
- T1 (1)
- T3s (1)
- TGF-BETA (1)
- TGN1412 (1)
- TIC disorder (1)
- TMS (1)
- TNF-R1 (1)
- TNF-R2 (1)
- TNF-alpha (1)
- TNF-α (1)
- TO-target interval (1)
- TOJ (1)
- TRPC6 (1)
- Tabu-Search (1)
- Tanzania (1)
- Tapeworm (1)
- Taste (1)
- Temperatur (1)
- Terahertz (1)
- Terahertz spectroscopy (1)
- Terrylenbisimid (1)
- Terrylenderivate (1)
- Terrylene bisimide (1)
- Text Mining (1)
- Theoretische Chemie (1)
- Therapie (1)
- Thiostrepton (1)
- Thrombectomy (1)
- Thrombozytenaggregation (1)
- Tiergesellschaft (1)
- Time Series Analysis (1)
- Time hole (1)
- Topolgical Phase (1)
- Topological Insulator (1)
- Topologische Isolatoren (1)
- Topologischer Isolator (1)
- Topology (1)
- Total nodal irradiation (1)
- Toulmin Modell (1)
- Toxikologie (1)
- Translokation (1)
- Transmissionsblockierende Impfstoffe (1)
- Transplantat-Wirt-Reaktion (1)
- Trend test (1)
- Triclosan (1)
- Trigger System (1)
- Tuberkulose (1)
- Tumor thrombus (1)
- Tumor-Nekrose-Faktor <alpha> (1)
- Tunnel emergencies (1)
- Tunneling spectroscopy (1)
- Typ 1 (1)
- Type 1 diabetes (1)
- USA (1)
- UV-VIS-Spektroskopie (1)
- Ultrafast spectroscopy (1)
- Ultrakurzzeit Spektroskopie (1)
- Ultrakurzzeitspektroskopie (1)
- Ultraschall (1)
- Ultraschalldiagnostik (1)
- Umweltgefährdung (1)
- United States (1)
- Univted-States (1)
- Unternehmenskooperation (1)
- Unwetter (1)
- Uzbekistan (1)
- VAL66MET polymorphism (1)
- Vaccine (1)
- Vaccinia Virus Replikation (1)
- Vaccinia virus (1)
- Variationsrechnung (1)
- Variovorax paradoxus (1)
- Vektorboson (1)
- Verarbeitungsflüssigkeit (1)
- Verbrauch (1)
- Verbreitungsgrenzen (1)
- Verfahren der konjugierten Gradienten (1)
- Verhalten (1)
- Verkehrspsychologie (1)
- Verkehrsunfall (1)
- Verschränkung (1)
- Verteiltes System (1)
- Vertretbarkeit (1)
- Video Streaming (1)
- Videoübertragung (1)
- Virtuelle Realitaet (1)
- Visualisierung (1)
- Visualization (1)
- Vorurteil (1)
- WISP1/CCN4 (1)
- WNT signaling pathway (1)
- WW (1)
- WZ production (1)
- Wachstum (1)
- Wahrnehmung (1)
- Warnung (1)
- Warteschlangennetz (1)
- Weisheit (1)
- West-Africa (1)
- Wetter (1)
- Wireless Sensor/Actuator Systems (1)
- Wirkstofffreisetzung (1)
- Wirkungsquerschnitt (1)
- Wisdom and Justifiability (1)
- Wissensbanksystem (1)
- Wissensmanagement (1)
- Wohnbau (1)
- Währungsunion (1)
- Wärmekraftwerk (1)
- Würmer (1)
- XA (1)
- Xmrk (1)
- Yersinia (1)
- Yersinia pestis (1)
- Yolk protein (1)
- Z Boson (1)
- Z boson (1)
- Zebrabärbling (1)
- Zeitdifferenzierung (1)
- Zeitoptimale Regelung (1)
- Zelladhäsion (1)
- Zelltransport (1)
- Zellzyklus (1)
- Zusammenstoss (1)
- Zustandsraummodelle (1)
- a-posteriori error estimates (1)
- abdominal (1)
- abdominal wall hernia (1)
- abdominal wall surgery (1)
- abiotic formation (1)
- abscisic acid (1)
- absolute configuration (1)
- accelerated atherosclerosis (1)
- acetivorans C2A (1)
- acoustic communication (1)
- acoustic startle (1)
- actin cortex (1)
- actin cytoskeleton (1)
- actinomycetes (1)
- action planning (1)
- action-effects (1)
- activated-receptor gamma (1)
- activation (1)
- activation mechanism (1)
- acute ischemic stroke (1)
- acute myeloid leukemia (1)
- acute renal failure (1)
- adaptation (1)
- adaption (1)
- adaptive refinement (1)
- addiction (1)
- addicts (1)
- additional jet (1)
- adenovirus (1)
- adhesion (1)
- adipose tissue (1)
- adjuvant hormonal treatment (1)
- adolescence (1)
- adsorption (1)
- adult bee (1)
- adult drosophila (1)
- age (1)
- age-related osteoporosis (1)
- agency (1)
- aging (1)
- aging brain (1)
- agnoists (1)
- agonist (1)
- airway (1)
- akt (1)
- alagille syndrome (1)
- alias pilot trial (1)
- alignment (1)
- alkaline-phosphatase (1)
- alleles (1)
- alpha galactosidase (1)
- alpha-synuclein (1)
- alternative Konfliktlösung (1)
- alveoar echinococcosis (1)
- alveolar epithelium in vitro model, claudin-1, claudin-3, claudin-4, claudin-5 (1)
- aminoacyl-transfer-RNA (1)
- amplitude (1)
- amygdala (1)
- amyloid beta (1)
- amyotrophic lateral sclerosis (1)
- anal atresia (1)
- anaplastic large cell lymphoma (1)
- anemia (1)
- anesthetics (1)
- aneuploidy (1)
- aneurysm repair (1)
- angiography (1)
- angioplasty (1)
- angiotensin II (1)
- animal communication (1)
- animal ecology (1)
- animal model (1)
- animal models (1)
- animal-model (1)
- anion channel (1)
- annihilation (1)
- anoikis (1)
- anomaly mediation (1)
- anorectal malformation (1)
- ant communities (1)
- anterior insula (1)
- anthocyanins (1)
- anthropogenic noise (1)
- anti inflammation (1)
- anti-aquaporin-4 antibody (1)
- anti-proliferative effects (1)
- anti-protease (1)
- anti-tumor agents (1)
- antibacterial activity (1)
- antibiotic resistance (1)
- antibodies (1)
- antibody (1)
- anticipation (1)
- anticipatory mechanisms (1)
- antidepressant (1)
- antigen (1)
- antigen expression (1)
- antigen presentation (1)
- antigen-B (1)
- antimicrobial (1)
- antimicrobial activity (1)
- antioxidant (1)
- antisense RNA (1)
- antisense RNAs (1)
- ants (1)
- anxiety like (1)
- aortic-valve (1)
- apolipoprotein E (1)
- appliances (1)
- approximation algorithm (1)
- aquaporin 3 protein (1)
- aquaporin-4 autoantibodies (1)
- aquired resistance (1)
- arabidopsi (1)
- arabidopsis (1)
- arabidopsis thaliana (1)
- arabidpsis thaliana (1)
- aral sea basin (1)
- archwires (1)
- area (1)
- arf (1)
- arginine methylation (1)
- arm (1)
- artery occlusion (1)
- arthritis (1)
- aryl hydrocarbon receptor (AhR) (1)
- asbestos (1)
- asparaginase (1)
- asparagine (1)
- asparagine synthetase (1)
- aspergillosis (1)
- assessment (1)
- assisitvetechnology (1)
- assisted reproductive techniques (1)
- associative learning (1)
- astrocyte (1)
- astrocytic tumor (1)
- astroglia (1)
- astrogliosis (1)
- atherothrombosis (1)
- atomic-force microscopy (1)
- atrial fibrillation (1)
- atrial natriuretic peptide (1)
- attention (1)
- auditory discrimination (1)
- auditory masking (1)
- aureus infections (1)
- auto-calibration (1)
- autologous chondrocyte implantation (1)
- autophagy (1)
- avaliação de risco (1)
- axial skeletal defects (1)
- axonal degeneration (1)
- axonopathic changes (1)
- bZIP (1)
- bacillus calmette guerin (1)
- back pain (1)
- background (1)
- background cross section (1)
- background expectation (1)
- bacterial meningitis (1)
- bacterial persistence (1)
- bacterial signal molecule (1)
- bactericidal activity (1)
- balance (1)
- balloon distension (1)
- barley (1)
- baroreflex mechanism (1)
- basal cell (1)
- basin hopping (1)
- beaver-dam eye (1)
- bee larva (1)
- behavior (1)
- behavioral addiction (1)
- benzo[a]pyrene (1)
- beta actin (1)
- bi-steerable robot (1)
- biflavanoids (1)
- big brown bats (1)
- bilayers (1)
- binary tanglegram (1)
- biocompatibility (1)
- bioconjugate (1)
- bioengineering (1)
- biogenic amines (1)
- biolabelling (1)
- biomarker (1)
- bioorganometallic chemistry (1)
- bipolar disorder (1)
- birth defects (1)
- bitter taste (1)
- blastocysts (1)
- bleomicina (1)
- bleomycin (1)
- blood biomarker (1)
- blood brain barrier (1)
- blood sampling (1)
- blood-brain-barrier (1)
- blood-stream forms (1)
- blowfly calliphora-vomitoria (1)
- body <motif> (1)
- bone disease (1)
- bone marrow (1)
- bone metabolism (1)
- bone mineral density (1)
- bone-mineral density (1)
- brain barrier (1)
- brain cancer (1)
- brain computer interface (1)
- brain development (1)
- brain edema (1)
- brain tumours (1)
- brain-computer-interface (1)
- brain–computerinterface (1)
- brucei (1)
- burned savanna (1)
- cEND (1)
- caenorhabditis elegans (1)
- caffeine-induced anxiety (1)
- call (1)
- calorimeter response (1)
- camp signaling pathway (1)
- cancer patients (1)
- cancer-cells (1)
- candidate gene (1)
- canine cancer therapy (1)
- canopy fogging (1)
- capacity (1)
- capsid protein (1)
- carcinogenicity (1)
- cardiac aging (1)
- cardiac arrhythmia (1)
- cardiac fibrosis (1)
- cardiac hyperthrophy (1)
- cardiac protection (1)
- cardiovascular arousal (1)
- cardiovascular disease (1)
- cardiovascular events (1)
- cardiovascular magnetic resonance (1)
- cardiovascular risk factors (1)
- care (1)
- carotid artery (1)
- case-control study (1)
- cased-control studies (1)
- catalytic (1)
- catenin (1)
- catheter tip (1)
- causal belief (1)
- causality (1)
- caveolin-1 (1)
- cavity (1)
- cavity polaritons (1)
- cell adhesion (1)
- cell carcinoma (1)
- cell death (1)
- cell surface (1)
- cell-cycle arrest (1)
- cell-cycle regulation (1)
- cell-line (1)
- cell-penetrating peptides (1)
- cellular-trafficking (1)
- centomeres (1)
- central corneal thickness (1)
- central nervous system (1)
- centromere (1)
- cephalic-vagal influences (1)
- cerebrospina (1)
- cerebrospinal fluid (1)
- cerebrospinal fluid culture (1)
- cerebrospinal-fluid (1)
- chain (1)
- chalinolobus-tuberculatus (1)
- charge misidentification (1)
- chargino --> neutralino pi (1)
- chargino decay (1)
- chargino lifetime (1)
- chargino mass (1)
- charingo mass (1)
- chemistry (1)
- chemosensory protein (1)
- chemosensory system (1)
- childhood cancer (1)
- children born (1)
- chiral boson (1)
- chlorella (1)
- chlorophyll fluorescence (1)
- cholinergic neurons (1)
- choroid-plexus (1)
- chromatin (1)
- chronic kidney disease (1)
- church (1)
- cigarette smoking (1)
- ciliary neurotrophic factor (CNTF) (1)
- ciliolenticular block glaucoma (1)
- circadian photoreception (1)
- circular dichroism (1)
- cis-element modules (1)
- clara cell (1)
- classifiaction (1)
- climate action plan (1)
- climate modelling (1)
- clinical diagnosis (1)
- clinical practice (1)
- clinical trial (1)
- clinical trials (1)
- clock (1)
- cluster (1)
- co-infection (1)
- coa reductase inhibitors (1)
- cochlear implant (1)
- coding strategy (1)
- coexpression (1)
- cognitive control (1)
- coloteral cancer (1)
- commercial preparations (1)
- communication (1)
- community sample (1)
- compartmentalization (1)
- complement factor-H (1)
- complex stability (1)
- computational model (1)
- conditional promoter replacement (1)
- confinement (1)
- conformal field theory (1)
- congenital malformations (1)
- conjugate (1)
- connector (1)
- conservation (1)
- consolidation (1)
- consortium (1)
- contact force (1)
- containing GABA(A) receptors (1)
- containing neurons (1)
- contaminants (1)
- context (1)
- contingent negative-variation (1)
- continuous performance-test (1)
- contralateral breast cancer (1)
- contrast (1)
- contrast-enhanced MRI (1)
- contrast-enhanced ultrasound. (1)
- conversion (1)
- cooperative-oncology-group (1)
- coordination (1)
- copy number variants (1)
- core depression (1)
- coronary artery bypass (1)
- coronary disease (1)
- coronary-heart-disease (1)
- coronene (1)
- cortex (1)
- corticotropin-releasing hormone (1)
- coupling strength (1)
- courtship displays (1)
- crantiectomy (1)
- criteria (1)
- critically ill (1)
- cropland abandonment (1)
- cross section measurement (1)
- cross section time (1)
- cross-sectional studies (1)
- crossing minimization (1)
- crosstalk (1)
- crystal structure (1)
- ctdsp2 (1)
- cubic-monoclinic martensites (1)
- cultivation (1)
- cultural identity (1)
- cultured hippocampal-neurons (1)
- cyanelle (1)
- cymantrene (1)
- cystic fibrosis (1)
- cytogenetic effects (1)
- cytokine (1)
- cytokines (1)
- cytotoxicity (1)
- dSTORM (1)
- damage (1)
- damage cool aid (1)
- dart-poison frog (1)
- data-to-parameter ratio = 14.0. (1)
- data-to-parameter ratio = 14.6 (1)
- data-to-parameter ratio = 20.8 (1)
- data-to-parameter ratio = 22.3 (1)
- database (1)
- dead region (1)
- death (1)
- decay (1)
- decompressive surgery (1)
- deep sequencing (1)
- deep-vein thrombosis (1)
- defective Mitosis (1)
- deficit hyperactivity disorder (1)
- deficit-hyperactivity disorder (1)
- dehydrogenases (1)
- delays progression (1)
- demyelination (1)
- dendrimer (1)
- dental casting alloys (1)
- dentate gyrus (1)
- dependent magnetosensitvity (1)
- depth (1)
- derivates (1)
- derivation (1)
- dermatite flagelada (1)
- dermatitis (1)
- descriptive epidemiology (1)
- deseases (1)
- detector track (1)
- detoxified lipooligosaccharide (1)
- developmental dyslexia (1)
- diabetes (1)
- diagnostic (1)
- diazepinomicin (1)
- differential diagnosis (1)
- diffractive dissociation (1)
- diketopiperazines (1)
- dilepton channel (1)
- dilepton invariant mass (1)
- dilepton invariant mass, (1)
- dilepton mass (1)
- dimer (1)
- dimer method (1)
- dimerer Naphthylisochinolin-Alkaloide (1)
- diphoton invariant mass (1)
- direct pair production (1)
- discourse analysis (1)
- discrete (1)
- disease-modifying therapies (1)
- disorder (1)
- disrupting chemicals (1)
- disruptor endócrino (1)
- dissipative Umgebung (1)
- dissipative environments (1)
- dissociation process, (1)
- district (1)
- disturbance (1)
- disulfide bonds (1)
- dogs (1)
- dosage (1)
- double knockout mice (1)
- double-blind (1)
- doublecortine-like (1)
- drosophila embryo (1)
- drosophila melanogaster (1)
- drosophila mushroom body (1)
- drug addiction (1)
- drug delivery (1)
- drug development (1)
- drug release (1)
- drug research and development (1)
- drug therapies (1)
- drug therapy (1)
- duchenne muscular dystrophy (1)
- dwelling bat (1)
- dyes (1)
- dynamics (1)
- dysfunction (1)
- dyspeptic symptoms (1)
- early diagnosis (1)
- eating disorders (1)
- ecosystem (1)
- electromagnetic calorimeter (1)
- electromigration (1)
- electron energy deposition (1)
- electron probe microanalysis (1)
- electronic states (1)
- electroweak background (1)
- elementary mode analysis (1)
- elements (1)
- elongation (1)
- embolic stroke (1)
- embryonale Maus (1)
- embryonic stem cells (1)
- emission-computed-tomography (1)
- emotional experience (1)
- enatnglement measure (1)
- encephalitis (1)
- endocrine disruptor (1)
- endogenous psychoses (1)
- endogenous shifts of attention (1)
- endothelial cell interactions (1)
- endothelial growth-factor (1)
- endotheliopathy (1)
- energy (1)
- energy conservation (1)
- energy dissipation (1)
- energy expenditure (1)
- energy landscapes (1)
- energy scale (1)
- energy scale uncertainty (1)
- engineered measles-virus (1)
- engineering (1)
- enoxaparin (1)
- entanglement (1)
- environmental phenols (1)
- environmental regulation (1)
- enzyme (1)
- enzyme replacement therapy (1)
- epicutaneous (1)
- epidemic (1)
- epidemiology (1)
- epigastric hernia (1)
- epimutation (1)
- epithelial-mesenchymal transition (1)
- epithelium (1)
- eptesicus-fuscus (1)
- erythropoietin (1)
- escherichia coli K-12 (1)
- estrogen receptor (1)
- estrogens (1)
- eucera berlandi (1)
- eukaryotes (1)
- evacuation behavior (1)
- event rates (1)
- event selcetion cut (1)
- event shape observable (1)
- event shape variable (1)
- event-related potential (1)
- event-related potentials (1)
- event-relatedpotentials (1)
- exchange factor collybistin (1)
- excited state (1)
- exciton (1)
- excitons (1)
- exercise (1)
- experimental (1)
- experimental results (1)
- experimental stroke (1)
- experimental systematic uncertainty (1)
- exposição humana (1)
- expressed sequence tag (1)
- expression pattern (1)
- expression signature (1)
- extensiv transverse myelitis (1)
- extracellular matrix (1)
- extractives (1)
- extrapolation factor (1)
- extreme value theory (1)
- extreme weather event (1)
- eyes (1)
- fMRI (1)
- face perception (1)
- facial expression (1)
- factor 1-alpha (1)
- factor EEF1A2 (1)
- factor H (1)
- factor prevents (1)
- failure (1)
- families (1)
- family (1)
- fear-potentiated startle (1)
- features (1)
- feeding behavior (1)
- fehlerhafte Mitose (1)
- femoral hernia (1)
- femtosecond spectroscopy (1)
- fetal liver (1)
- fibrosis progression (1)
- fiducial cross section (1)
- field gel-electrophoreresis (1)
- fine structure processing (1)
- fission yeast (1)
- fixed-parameter tractability (1)
- flagellar (1)
- flagellate dermatitis (1)
- flagellum (1)
- flavenoids (1)
- flavour changing (1)
- fluid (1)
- fluid networks (1)
- fluorescence detection (1)
- fluorescent protein (1)
- fluoride (1)
- forced-choice (1)
- forest (1)
- forest disturbance (1)
- forest soils (1)
- formaldehyde (1)
- fosfomycin (1)
- fracture (1)
- fragmin (1)
- free radical scavenger (1)
- free-choice (1)
- frontotemporal dementia (1)
- frontotemporal lobar degeneration (1)
- fruit fly (1)
- fumonisin B1 (1)
- functional D-norm (1)
- functional Renormalization Group (1)
- functional absorption cross section of PS II (1)
- functional imaging (1)
- functional neuroanatomy (1)
- functional neuroimaging (1)
- functional renormalization group (1)
- fungos shiitake (1)
- gadofluorine (1)
- gadolinium-DTPA (1)
- gait (1)
- galvanic corrosion (1)
- gametocyte (1)
- gamma (1)
- gamma-aminobutyric-acid (1)
- gamma-interferon (1)
- gene conversion (1)
- gene delivery (1)
- gene environment interaction (1)
- gene family targeting (1)
- geneexpression (1)
- general stress response (1)
- generalized anxiety disorder (1)
- genetic interaction (1)
- genetic loci (1)
- genetic modifiers (1)
- genetic renal disease (1)
- genetics of disease (1)
- genome-wide scan (1)
- genotoxicity (1)
- genotyping (1)
- geometrically linear elasticity (1)
- geometrisch lineare Elastizitätstheorie (1)
- gephyrin (1)
- glaucoma surgery (1)
- glia (1)
- glioblastoma cell-lines (1)
- glioblastoma multiforme (1)
- glomerulonephritis (1)
- glossy11 (1)
- glucagon-like peptide-1 (GLP-1) (1)
- glucokinase (1)
- glut1 (1)
- glv-1h68 (1)
- glycine (1)
- glycoprotein Ib (1)
- go/no-go task (1)
- goldmann applanation tonometer (1)
- good agreement (1)
- gp130 (1)
- gradient (1)
- grading system (1)
- graft surgery (1)
- granulosus (1)
- granzyme B (1)
- gravidez (1)
- growing escherichia coli (1)
- growth factor (1)
- growth rate control (1)
- growth regulator (1)
- growth-factor receptor (1)
- guanine nucleotide exchange factor (1)
- guttiferae (1)
- hadron hadron scattering (1)
- hadronic final state (1)
- hadronisation model (1)
- haemolymph (1)
- hardwood dust (1)
- harmonia axyridis (1)
- harmonine (1)
- head involution (1)
- health-related quality of life (1)
- hearing loss (1)
- heart (1)
- heart development (1)
- heart-rate-variability (1)
- heartbeat perception (1)
- heat shock protein Hsc-70 (1)
- heavy flavour (1)
- heavy flavour quark (1)
- heavy neutrino (1)
- helicase BRIP1 (1)
- helicity fraction (1)
- helper T cells (1)
- hemagglutinin (1)
- hemicraniectomy (1)
- hemodialysis (1)
- hemophilus influenzae (1)
- hepatotoxicity (1)
- herbivore-parasitoid interaction (1)
- hereditary motor and sensory neuropathy (1)
- heritability (1)
- hernia defect (1)
- hernia repair material (1)
- heterostructures (1)
- hexanucleotide repeat (1)
- hierarchy (1)
- high jet multiplicity (1)
- high-dose atorvastatin (1)
- high-resolution analysis (1)
- high-temperature NMR (1)
- higher pitch (1)
- highland malaria (1)
- highlands (1)
- hindbrain boundary (1)
- hippocampal neurogenesis (1)
- histidine kinase (1)
- homeostasis (1)
- homology modeling (1)
- honey bee (1)
- honey bees (1)
- honeybees (1)
- hormone flow modelling (1)
- hormone-related protein (1)
- host cell death (1)
- host genetics (1)
- human (1)
- human cancer diseases (1)
- human diseases (1)
- human endothelial cells (1)
- human exposure (1)
- human factor H (1)
- human genetics (1)
- human jagged1 (1)
- human keratinocytes (1)
- human monocytes (1)
- human parthenogenetic neural stem cells (1)
- human parthenogenetic stem cells (1)
- human pathogens (1)
- humaner Faktor H (1)
- humans (1)
- hybrid (1)
- hydatid disease (1)
- hydrodynamics (1)
- hymenoptera (1)
- hyper-IL-6 (1)
- hyperekplexia (1)
- hypertension (1)
- idiotype (1)
- imaging genetics (1)
- immortalization (1)
- immune response (1)
- immune suppression (1)
- immune-response (1)
- immunity (1)
- immunization (1)
- immunoglobulin-G (1)
- immunohistochemistry (1)
- immunology (1)
- immunosenescence (1)
- immunostaining (1)
- imperforate anus (1)
- imprinting. (1)
- in situ guided tissue regeneration (1)
- in vitro cell culture models (1)
- in vitro neural differentiation (1)
- in vivo imaging (1)
- in-vitro fertilization (1)
- in-vitro propagation (1)
- in-vivo (1)
- inactivation (1)
- incisional abdominal wall hernia (1)
- incisional hernia (1)
- inclusive cross section (1)
- inclusive jet sample (1)
- individual systematic uncertainty (1)
- individual-based simulation (1)
- induction (1)
- infants born (1)
- infected bee (1)
- infection (1)
- infiltrate (1)
- inflammatory cytokines (1)
- inflammatory mechanisms (1)
- influenza (1)
- information (1)
- ingle-molecule microscopy (1)
- inguinal hernia (1)
- inhibitory synapse (1)
- inos (1)
- insecticides (1)
- instrument (1)
- insulin pathway (1)
- insulin receptor (1)
- integration (1)
- intensity-modulated radiotherapy (1)
- intent (1)
- intentional binding (1)
- interacting species (1)
- interaction (1)
- interaktive Arten (1)
- interferon gamma (1)
- interferon-gamma (1)
- interleukin 6 (1)
- interleukin-1 receptor antagonist (1)
- interleukin-6-type cytokines (1)
- internal fixation (1)
- internal transcribed spacer 2 (1)
- internalization studies (1)
- intervention (1)
- intraarticular fractures (1)
- intracellular pathogen (1)
- intractable hiccup (1)
- intramolecular Michael addition (1)
- intravenous glucose tolerance test (1)
- invadopodia (1)
- invariant mass (1)
- invariant mass distribution (1)
- invariant mass resolution (1)
- investigators (1)
- iodine contrast (1)
- ionizing radiation (1)
- iron oxide nanoparticles (1)
- iron-pnictides (1)
- ischaemic stroke (1)
- ischemia (1)
- ischemia-reperfusion injury (1)
- ischemic cascade (1)
- ischemic stroke (1)
- isolation requirement (1)
- isthmic oragnizer (1)
- italian population (1)
- jet axis (1)
- jet background (1)
- jet calibration (1)
- jet cross section (1)
- jet energy (1)
- jet energy measurement (1)
- jet multiplicity (1)
- jet response (1)
- jet sample (1)
- jet scale energy (1)
- judgements (1)
- kidney (1)
- kingdom (1)
- kinin receptors (1)
- knock-out mice (1)
- knock-out mouse (1)
- knockout mice (1)
- knockout-mice (1)
- kubisch-monokliner Phasenübergang (1)
- label-free analysis (1)
- lacking (1)
- laminopathies (1)
- land (1)
- land use (1)
- landscape (1)
- large rapidity gap (1)
- larva (1)
- laser suture lysis (1)
- learning performances (1)
- legionella pneumophila (1)
- lepton flavour (1)
- leptonic final state (1)
- lesion formation (1)
- lesion size (1)
- leukemia-inhibitory factor (1)
- leukocyte adhesion (1)
- life events (1)
- life style (1)
- life-span regulation (1)
- light avoidance (1)
- lineage (1)
- linear trend analysis (1)
- lipid-lowering therapy (1)
- liver (1)
- livingstonei (1)
- local translation (1)
- locomotor activity (1)
- locus coeruleus (1)
- logistic regression modeling (1)
- lokale Proteinsynthese (1)
- long-term reuse (1)
- long-term-memory (1)
- low molecular weight (1)
- lower limit of normal (1)
- lower reaches of Amu Darya River (1)
- mRNA processing (1)
- macrophage (1)
- macrophages (1)
- macular degeneration (1)
- maculopathy (1)
- magnetic resonsance imaging (1)
- magnetic-resonance-spectroscopy (1)
- major depression (1)
- majorana bound states (1)
- malaria model (1)
- malaria projection (1)
- male bees (1)
- malignant MCA infarct (1)
- malignant glaucoma (1)
- malignant pleural mesothelioma (1)
- mammalian CRY1 (1)
- mammalian cells (1)
- mammographic density (1)
- mapping function (1)
- marathon running (1)
- marine sponge (1)
- markers (1)
- masked priming (1)
- mass spectometry (1)
- mast cells (1)
- matrix metalloproteinase (1)
- matrix metalloproteinases (1)
- maxillary sinus (1)
- mean σ(C–C) = 0.003 Å (1)
- mean σ(C–C) = 0.004 Å (1)
- measles virus (1)
- mechanism (1)
- mechanismofaction (1)
- medaka (1)
- media communication (1)
- mediated apoptosis (1)
- medicine (1)
- megavoltage computed-tomography (1)
- melatonin (1)
- memory (1)
- memory suppression (1)
- meningococcal disease (1)
- mesenchymal cells (1)
- mesenchymal stem cells (1)
- mesenchymal tissues (1)
- mesenchymale Stammzellen (1)
- mesh augmentation (1)
- mesh repair (1)
- metabolic flux (1)
- metabolism (1)
- metacestode vesicles (1)
- metagenomics (1)
- metal-to-insulator transition (1)
- metallurgical characterization (1)
- methane emissions (1)
- methanol methyltransferase isozymes (1)
- methanosarcina mazei GO1 (1)
- methicillin (1)
- method development (1)
- methyl-bromide (1)
- methylation (1)
- methylene blue (1)
- methylphenidate (1)
- miR-22 (1)
- miR-26b (1)
- miRNA (1)
- miRNS (1)
- mices (1)
- microRNA (1)
- microRNAs (1)
- microangiopathy (1)
- microarray (1)
- microarrays (1)
- microdeletion (1)
- microdomains (1)
- micronucleus assay (1)
- microscopy (1)
- microvascular density (1)
- microvascular endothelial cells (1)
- microvascular endothelial-cells (1)
- microvessel permeability (1)
- mimecan (1)
- mimicry (1)
- minimal inhibitory concentration (1)
- mirrorneuronsystem (1)
- mismatch negativity mmn (1)
- mitochondria (1)
- mitochondrial dysfunction (1)
- modelo PBPK/PBTK (1)
- models (1)
- modules (1)
- molecular epidemiology (1)
- molecular genetics (1)
- molecular systematics (1)
- molecular transport (1)
- molybdenum (1)
- molybdenum cofactor biosynthesis (1)
- momentum scale (1)
- monoamine transporters (1)
- monoclonal antibody (1)
- monocycline (1)
- monolayer graphite (1)
- mononuclear phagocytes (1)
- monozygotic twins (1)
- morphogenetic protein (1)
- moth manduca sexta (1)
- motility (1)
- motoneurons (1)
- motor function (1)
- motor neuron (1)
- motor preparation (1)
- motor-neuron protein (1)
- mouse (1)
- mouse model (1)
- movement ecology (1)
- movements (1)
- mulitple-sclerosis patients (1)
- multi-band superconductivity (1)
- multi-wavelength (1)
- multicenter (1)
- multicomponent Ugi-type reaction (1)
- multifactorial (1)
- multiflora (1)
- multijet event (1)
- multilocularis (1)
- multiparticle collision dynamics (1)
- multiple myeloma (1)
- multiple system atrophy (1)
- multiple-sclerosis (1)
- muon (1)
- muon decay channel (1)
- muon reconstruction efficiency (1)
- muon spectrometer (1)
- murine leishmaniasis (1)
- muscle force (1)
- mushroom bodies (1)
- music (1)
- mutagenicity (1)
- mutant mice (1)
- myasthenia gravis (1)
- mycobacterium-tuberculosis (1)
- mycotoxin (1)
- myelination (1)
- myeloid derived suppressor cells (1)
- myoelectric activity (1)
- myosin-VI (1)
- nano (1)
- nanoelectromechanical systems (1)
- nanographenes (1)
- nanowires (1)
- nasal cancer (1)
- nasal lavage (1)
- nasal snuff (1)
- nasal spray (1)
- nasopharyngeal carcinoma (1)
- nasopharyngeal colonization (1)
- natural history (1)
- necrosis-factor-alpha (1)
- neisseria gonorrhoeae (1)
- neisseria meningitidis (1)
- neobellieria bullata (1)
- neonates (1)
- nephrotoxicity (1)
- nervour system (1)
- nervous system (1)
- nervous-system (1)
- netcar-feeding bats (1)
- neural apoptosis (1)
- neural crest (1)
- neurite outgrowth (1)
- neurobehavioural deficits (1)
- neuroinflammation (1)
- neuronal differentiation (1)
- neuronale Differenzierung (1)
- neurons form (1)
- neuropathy (1)
- neuropsychology (1)
- neurorepair (1)
- neuroscience (1)
- neurothrophic factor (1)
- neurovirulence (1)
- neutral Higgs boson (1)
- neutral currents (1)
- neutral loss (1)
- neutrophils (1)
- nichtholonomes System (1)
- nickel (1)
- nickel release (1)
- nicotine addiction (1)
- nicotinic acetylcholine-receptors (1)
- nitric oxide synthase (1)
- nitricoxidesynthase (1)
- non-convex optimal control problems (1)
- nonalcoholic steatohepatitis (1)
- noncooperative binding (1)
- nonholonomic system (1)
- noninvasive detection (1)
- nonribosomal peptide synthetase (1)
- noradrenalin (1)
- norepinephrine (1)
- novelty detection (1)
- nuclear envelope (1)
- nuclear lamina (1)
- nuclear organization (1)
- nuclear transport (1)
- nucleosome (1)
- nucleotide exchange (1)
- nucleotide excision-repair (1)
- nucleus (1)
- nude mice (1)
- numerical approximations (1)
- nutrient uptake (1)
- nutrients (1)
- nyctalus noctula (1)
- obstructive pulmonary disease (1)
- occupational exposures (1)
- odourants (1)
- oncogenes (1)
- oncolytic therapy (1)
- oncolytic virus (1)
- one-dimensional (1)
- onset (1)
- open reduction (1)
- ophrys heldreichii (1)
- optical coherence tomography (1)
- organic bulk heterojunction solar cell (1)
- organic chemistry (1)
- organic photovoltaics (1)
- organic solvents (1)
- organische Photovoltaik (1)
- organische Solarzelle (1)
- organization (1)
- organogenesis (1)
- organometal complexes (1)
- organometallic complexes (1)
- organosilicon (1)
- orthodontic brackets (1)
- oscillator (1)
- osteoblast differentiation (1)
- osteochondral allografts (1)
- osteogenesis imperfecta (1)
- osteoglycin (1)
- osteoporosis (1)
- otitis media (1)
- outer membrane protein (1)
- outer-membrane proteins (1)
- oxide (1)
- p53 (1)
- pair invariant mass (1)
- pancreatic cancer (1)
- panic disorder (1)
- panton-valentine leukocidin (1)
- paradigm (1)
- paranasal sinuses (1)
- parastomal hernia (1)
- parathyroid hormone (1)
- parathyroid-hormone (1)
- parent-child agreement (1)
- parkinson disease (1)
- pars plana vitrectomy (1)
- partial purification (1)
- particle level jet (1)
- partitioning analysis RPA (1)
- parton shower (1)
- pathogenicity island 2 (1)
- pathophysiology (1)
- pathways (1)
- pea (1)
- pediatric lymphoma (1)
- people (1)
- peptide (1)
- peptides (1)
- percutaneous fixation (1)
- performance liquid-chromatography (1)
- perfusion (1)
- period variability (1)
- persistent ADHD (1)
- persistierende Infektion (1)
- perylene bisimide (1)
- pesticides (1)
- pet (1)
- pet dogs (1)
- phagocytosis (1)
- phagosomalescape (1)
- phase variation (1)
- photocurrent (1)
- photoelectron spectroscopy (1)
- photoemission (1)
- photoinhibition (1)
- photon energy scale (1)
- photoprotection (1)
- photosystem II (1)
- phylogenetic tree (1)
- phylogeny (1)
- physical activity (1)
- physical time (1)
- pig or swine (1)
- pioglitazone (1)
- pitch (1)
- placebo-controlled (1)
- placebo-controlled trial (1)
- planning (1)
- plant-microbe interaction (1)
- plant–microbe interaction (1)
- plasma cells (1)
- plasmodium falciparum (1)
- platelet adhesion (1)
- platelets (1)
- plexus epithelial-cells (1)
- pluripotent (1)
- polarisation pulse shaping (1)
- political discourse (1)
- politischer Diskurs (1)
- pollination (1)
- polyarcylamide gels (1)
- polymavirus (1)
- polymorphism (1)
- polymorphisms (1)
- polyomavirus (1)
- population (1)
- population biology (1)
- pore formation and translocation (1)
- positron-emission-tomography (1)
- post-transcriptionalregulation (1)
- posttraumatic-stress-disorder (1)
- pp collision (1)
- pragmatics (1)
- pre-messenger RNA (1)
- predation risk (1)
- prediction (1)
- predictivetextentry (1)
- predictors (1)
- pregnancy (1)
- prenatal stress (1)
- prepulse inhibition (1)
- preterm (1)
- preterm infants (1)
- primary prevention (1)
- primary ventral hernia (1)
- primary-care physicians (1)
- printed paper photovoltaics (1)
- probes (1)
- processing deficits (1)
- producation cross section (1)
- production cross section (1)
- progenitor cells (1)
- prognostic index (1)
- prognostic relevance (1)
- prognostic value (1)
- proliferation (1)
- promoter (1)
- promoter methylation (1)
- propagation (1)
- prophylaxis (1)
- propulsion (1)
- prostate (1)
- prostate cancer (1)
- protein argentine methyltranserase (1)
- protein disulfide isomerase (1)
- protein docking (1)
- protein familiy (1)
- protein folding (1)
- protein subunit (1)
- protein synthesis (1)
- protein-interaction networks (1)
- proteins (1)
- proteinuria (1)
- proteolipid protein gene (1)
- proton (1)
- präemptiver Schlag (1)
- pränataler Stress (1)
- pseudomas-syringae (1)
- psoas muscle (1)
- psychopathology (1)
- psychosis (1)
- pulmonary embolism (1)
- pulmonary gas-exchange (1)
- pyrococcus furiosus (1)
- pythia parton shower (1)
- quali-chick chimeras (1)
- quality-of-life (1)
- quantitative trait locus (1)
- quantized vortices (1)
- quantum chemistry (1)
- quantum field theory (1)
- queueing networks (1)
- radiation oncology (1)
- radiofrequency ablation (1)
- radiotherapy (1)
- rain forest (1)
- raman spectroscopy (1)
- randomized-trial (1)
- range formation (1)
- rapidity interval (1)
- rare (1)
- rare decays (1)
- rat (1)
- rat calyx (1)
- rat heart (1)
- rat spinal-cord (1)
- reaction centre (1)
- reactivity (1)
- reading disability (1)
- real-time glucose monitoring (1)
- receptor clustering (1)
- receptor-beta subunits (1)
- receptors (1)
- recolonization (1)
- recombination (1)
- recombination hotspot (1)
- reconstructed mass spectrum (1)
- reconstruction (1)
- recurrence (1)
- recurrent abdominal wall hernia (1)
- recursive Green's functions (1)
- regenerative medicine (1)
- region (1)
- regional climate model (1)
- regionales Klimamodell (1)
- registries (1)
- registry (1)
- regulation (1)
- regulatory RNA (1)
- regulatory T cell (1)
- regulatory T cells (1)
- relative abundance (1)
- releasable suture (1)
- relevance (1)
- renal disease (1)
- renal perfusion (1)
- renewable energies (1)
- renewal (1)
- replicating adenovirus (1)
- replicative senescence (1)
- reporter gene (1)
- reproductive medicine (1)
- rescue (1)
- resonant scattering (1)
- respiratory-distress-syndrome (1)
- response inhibition (1)
- response regulator (1)
- resting tremor (1)
- restricition enzymes (1)
- resummation (1)
- resurgence (1)
- resveratrol (1)
- retinal ganglion cells (1)
- retinocochleocerebral (1)
- retroviral infection (1)
- reward (1)
- rheumatoid (1)
- rhizobacteria (1)
- rhythm (1)
- ribonuclease-P (1)
- ribonucleases (1)
- ribwort plantain (1)
- richtersius coronifer (1)
- risk (1)
- risk assessment (1)
- risk factor (1)
- risk genes (1)
- room temperature (1)
- root (1)
- rotational diffusion (1)
- rs112587690 (1)
- rs12628 (1)
- rules (1)
- rural domain (1)
- ruthenates (1)
- sDMA (1)
- sRNA (1)
- safety (1)
- safety research (1)
- salmonella enterica (1)
- salt lakes (1)
- satellite rainfall products (1)
- sationary phase (1)
- satisfiability problems (1)
- savanna woodland (1)
- scaffolding protein gephyryrin (1)
- scaffolds (1)
- scanning tunneling microscopy (1)
- scattering (1)
- scattering amplitudes (1)
- scenarios (1)
- schizosaccaromyces-pombe (1)
- scid mice (1)
- scintigraphy (1)
- screening (1)
- secondary cancer (1)
- secondary prevention (1)
- secondary structure (1)
- seed protein concentration (1)
- segmental collapse (1)
- selective attention (1)
- self-assembly (1)
- self-rating (1)
- self-trapping (1)
- semi-convex hulls (1)
- semi-konvexe Hüllen (1)
- semiconductor microavity (1)
- semiconductors (1)
- sensitization (1)
- sensor (1)
- sepsis (1)
- sequence (1)
- sequence alignment (1)
- sequence imaging protocol (1)
- sequence-structure (1)
- sequential standard model (1)
- sequestration (1)
- serogroup B (1)
- serotonin (1)
- serotonin deficiency (1)
- serotonin transporter (1)
- serotonin transporter gene (1)
- set (1)
- severe renal insufficiency (1)
- sexual deception (1)
- sexual stage surface proteins (1)
- sglt1 (1)
- sheep model (1)
- shiitake dermatitis (1)
- shiitake mushrooms (1)
- shiitake-dermatite (1)
- shock (1)
- shock sigma factor (1)
- signal peptides (1)
- signal template (1)
- signals (1)
- simulaed event sample (1)
- simulated event sample (1)
- simulation (1)
- sinonasal cancer (1)
- size (1)
- skeletal overexpression (1)
- skin (1)
- skin cancer (1)
- slow cortical potentials (1)
- small RNA (1)
- small noncoding RNAs (1)
- small nucleolar RNAs (1)
- small vessel disease (1)
- smoking (1)
- smoking habits (1)
- smoking-cessation (1)
- snRNP (1)
- social calls (1)
- social teachings (1)
- sodium (1)
- soil macrofauna (1)
- soils/sediments (1)
- solid-phase extraction (1)
- solvent (1)
- somatic mosaicism (1)
- sonic hedghog (1)
- sorbents (1)
- soybean (1)
- sparticle cascade decay (1)
- sparticle pair production (1)
- spatial attention (1)
- spatial cueing (1)
- specialization (1)
- species composition (1)
- species richness (1)
- species richness estimation (1)
- specification (1)
- spectrofluorimetry (1)
- spectroscopy (1)
- spectrum disorders (1)
- spin-orbit coupling (1)
- spinal-cord (1)
- spiroplasma (1)
- splicing factor (1)
- spontaneous mouse mutants (1)
- sporadic Parkinson's disease (1)
- sptPALM (1)
- squamous cell (1)
- stage pT1 (1)
- standard heparin (1)
- standard model (1)
- states (1)
- stationary phase (1)
- steady state (1)
- stent (1)
- still-face (1)
- stochastic processes (1)
- stochastischer Prozess (1)
- stocks (1)
- strain (1)
- strain MC58 (1)
- stranded DNAs (1)
- strategies (1)
- strategy (1)
- streptozotocin (1)
- stress perfusion (1)
- string theory (1)
- stroke therapy (1)
- stromal cells (1)
- subacute sclerosing-panencephalitis (1)
- subpopulation (1)
- subspace clustering (1)
- substantia nigra (1)
- subunit (1)
- sufficient optimality conditions (1)
- summer rainfall (1)
- sumo (1)
- sumoylation (1)
- superoxide-dismutase (1)
- superresolution (1)
- supersymmetric standard model (1)
- supersymmetry (1)
- supersymmetry phenomenology (1)
- surface analysis (1)
- surface functionalisation (1)
- surfactant (1)
- surfactant protein-A (1)
- surrogate endpoints (1)
- survivin (1)
- survivin T-cell reactivity (1)
- survivors (1)
- susceptibility (1)
- susceptibility loci (1)
- swiss model (1)
- symbiosis (1)
- symmetry breaking (1)
- symptoms (1)
- synapse formation (1)
- synaptic inhibition (1)
- synechocystis (1)
- synthesis (1)
- synthesis silicon (1)
- synthetic biology (1)
- synthetic surfactant (1)
- systematic effect (1)
- systems (1)
- tPA (1)
- tandem mass-spectrometry (1)
- tardigrada (1)
- target molecule (1)
- task force (1)
- technology (1)
- teleconnection (1)
- temperature (1)
- temperatures (1)
- temporal order judgments (1)
- temporal-lobe epilepsy (1)
- tensor rank (1)
- tergite (1)
- teriparatide (1)
- term memory (1)
- territory infaction (1)
- think/no-think paradigm (1)
- thiostrepton (1)
- thrombosis (1)
- thymus (1)
- tight junctions (1)
- time (1)
- time hole (1)
- time series (1)
- time-optimal control (1)
- tissue microarray (1)
- tissue-plasminogen activator (1)
- titanium (1)
- to-disc ratio (1)
- top event dilepton invariant mass (1)
- top physics (1)
- top quark (1)
- top quark contribution (1)
- top quark masse (1)
- topology (1)
- total pancreatectomy (1)
- total systematic uncertainty (1)
- toxicity (1)
- toxicocinética (1)
- toxicokinetics (1)
- track data analysis (1)
- track momentum (1)
- track multipilicty (1)
- tracking (1)
- traffic noise (1)
- transcription activation (1)
- transcription factor (1)
- transcription factor MIZ-1 (1)
- transcription factors (1)
- transcription-3 (STAT3) (1)
- transcriptional regulator (1)
- transcriptome (1)
- transcriptomeanalysis (1)
- transcutaneous (1)
- transduction (1)
- transgenic mouse model (1)
- transient absorption spectroscopy (1)
- transient ischemic attack (1)
- transiente Absorptionsspektroskopie (1)
- transistors (1)
- transitional cell carcinoma (1)
- translation (1)
- translational initiation (1)
- translational research (1)
- translocation (1)
- transmission blocking vaccine (1)
- transverse momentum momentum spectrum (1)
- transverse momentum vector (1)
- transverse plane (1)
- tremor (1)
- triangular lattice (1)
- trinervitermes (1)
- tropical North-Africa (1)
- true diversity (1)
- trypanosome lytic factor (1)
- tryptophan (1)
- tube formation (1)
- tuberculous meningitis (1)
- tumor microenvironment (1)
- tumor necrosis factor (1)
- tumor specific antigen (1)
- tumor subtypes (1)
- tumor suppressor (1)
- tumor-draining lymph node (1)
- tumor-necrosis-factor (1)
- type 2 diabetes mellitus (1)
- typification (1)
- tyrosine kinase (1)
- tyrosine phosphorylation (1)
- ultrasoft pseudopotentials (1)
- ultrasound (1)
- ultrastructure (1)
- umbilical hernia (1)
- unconscious processing (1)
- unconverted photon (1)
- underlying event tune (1)
- unfractionated heparin (1)
- univentricular heart (1)
- unpaired median neurons (1)
- up regulation (1)
- upside-down faces (1)
- urothelial bladder carcinoma (1)
- user-centered (1)
- utilization distributions (1)
- vaccination (1)
- vaccines (1)
- vaccinia virus replication (1)
- validation region (1)
- validity (1)
- variant genotypes (1)
- vascular dementia (1)
- vasculopathy (1)
- vav2 (1)
- ventilation (1)
- ventral hernia (1)
- ventral hernia model (1)
- ventricular tachycardia (1)
- very-long-chain aldehydes (1)
- vibrio cholerae (1)
- vicinal surfaces (1)
- viral therapy (1)
- virotherapy (1)
- virtual reality (1)
- virus-induced encephalitis (1)
- visceral leishmaniasis (1)
- viscosity (1)
- visual-evoked potentials (1)
- vitamin C (1)
- vitamin-D-receptor (1)
- vitellogenin (1)
- vivo (1)
- voltage dependent (1)
- volume determination (1)
- von Willebrand factor (1)
- voxel-based morphometry (1)
- wR factor = 0.038 (1)
- wR factor = 0.052 (1)
- waking states (1)
- walking (1)
- water channels (1)
- water load test (1)
- water stress (1)
- wax (1)
- well (1)
- whole-brain radiotherapy (1)
- wires (1)
- women (1)
- wood dust (1)
- work bee (1)
- workbench (1)
- worker bee larva (1)
- young work bee (1)
- zeitoptimale Steuerung (1)
- zweiachsgelenkter Roboter (1)
- Ähnlichkeit (1)
- Übergangsmetallkomplexe (1)
- Übergangszustand (1)
- β-APP (1)
- “basic emotion” (1)
Institute
- Theodor-Boveri-Institut für Biowissenschaften (83)
- Fakultät für Physik und Astronomie (38)
- Graduate School of Life Sciences (32)
- Institut für Psychologie (25)
- Neurologische Klinik und Poliklinik (24)
- Institut für Molekulare Infektionsbiologie (23)
- Klinik und Poliklinik für Psychiatrie, Psychosomatik und Psychotherapie (21)
- Physikalisches Institut (19)
- Rudolf-Virchow-Zentrum (16)
- Lehrstuhl für Biochemie (15)
Sonstige beteiligte Institutionen
Objectives: To assess the subjective and objective performance of the new fine structure processing strategy (FSP) compared to the previous generation coding strategies CIS+ and HDCIS. Methods: Forty-six adults with a minimum of 6 months of cochlear implant experience were included. CIS+, HDCIS and FSP were compared in speech perception tests in noise, pitch scaling and questionnaires. The randomized tests were performed acutely (interval 1) and again after 3 months of FSP experience (interval 3). The subjective evaluation included questionnaire 1 at intervals 1 and 3, and questionnaire 2 at interval 2, 1 month after interval 1. Results: Comparison between FSP and CIS+ showed that FSP performed at least as well as CIS+ in all speech perception tests, and outperformed CIS+ in vowel and monosyllabic word discrimination. Comparison between FSP and HDCIS showed that both performed equally well in all speech perception tests. Pitch scaling showed that FSP performed at least as well as HDCIS. With FSP, sound quality was at least as good and often better than with HDCIS. Conclusions: Results indicate that FSP performs better than CIS+ in vowel and monosyllabic word understanding. Subjective evaluation demonstrates strong user preferences for FSP when listening to speech and music.
Primary prevention strategies, such as vaccinations at the age extremes, in neonates and elderly individuals, demonstrate a challenge to health professionals and public health specialists. The aspects of the differentiation and maturation of the adaptive immune system, the functional implications of immunological immaturity or immunosenescence and its impact on vaccine immunogenicity and efficacy will be highlighted in this review. Several approaches have been undertaken to promote Th1 responses in neonates and to enhance immune functions in elderly, such as conjugation to carrier proteins, addition of adjuvants, concomitant vaccination with other vaccines, change in antigen concentrations or dose intervals or use of different administration routes. Also, early protection by maternal vaccination seems to be beneficial in neonates. However, it also appears necessary to think of other end points than antibody concentrations to assess vaccine efficacy in neonates or elderly, as also the cellular immune response may be impaired by the mechanisms of immaturity, underlying health conditions, immunosuppressive treatments or immunosenescence. Thus, lifespan vaccine programs should be implemented to all individuals on a population level not only to improve herd protection and to maintain protective antibody levels and immune memory, but also to cover all age groups, to protect unvaccinated elderly persons and to provide indirect protection for neonates and small infants.
Elimination of pathogenic autoantibodies by immunoadsorption (IA) has been described as an effective adjuvant treatment in severe bullous autoimmune diseases, especially in pemphigus. There is much less experience in the treatment of bullous pemphigoid (BP). BP was diagnosed in a 62-year-old Caucasian woman presenting a pruritic rash with multiple tense blisters. Standard treatments with topical and oral corticosteroids, steroid-sparing agents including dapsone, azathioprine, mycophenolate mofetil (MMF) and intravenous immunoglobulins were ineffective or had to be discontinued due to adverse events. An immediate clinical response could be achieved by two treatment cycles of adjuvant protein A immunoadsorption (PA-IA) in addition to continued treatment with MMF (2 g/day) and prednisolone (1 mg/kg/day). Tolerance was excellent. Clinical improvement remained stable after discontinuation of IA and went along with sustained reduction of circulating autoantibodies. Our data demonstrate that PA-IA might be a safe and effective adjuvant treatment in severe and recalcitrant BP.
Background: Bowen’s disease (BD) of the nail unit is associated with human papillomavirus (HPV) infection. Objective: This study aimed to investigate the frequency of high-risk HPV infection, gender, age and digital distribution in this condition.
Methods: Biopsy specimens of 3 consecutive cases with periungual BD were investigated for the presence of HPV DNA by in situ hybridization and by polymerase chain reaction (PCR). Furthermore, 74 cases of ungual BD conducted with HPV genotyping as reported in the literature were reviewed.
Results: PCR of biopsy specimens revealed in 2 cases infection with HPV-16 and in 1 case with HPV-73. Additionally, in 1 HPV-16-positive case HPV-31/33 was detected by in situ hybridization. In line, review of the literature demonstrated a clear association of HPV-positive BD with high-risk HPV types. Interestingly, age at diagnosis was significantly lower in women. Whereas in both genders the second to fourth fingers on both hands were commonly diseased, only in men the thumbs were also prominently affected.
Conclusions: Infection with high-risk HPV types is common in BD of the nail unit suggesting the aetiological cause. Therefore, patients and partners should be closely followed up for digital and genital HPV-associated lesions.
The volatile anesthetic desflurane (DES) effectively reduces cardiac infarct size following experimental ischemia/reperfusion injury in the mouse heart. We hypothesized that endogenous estrogens play a role as mediators of desflurane-induced preconditioning against myocardial infarction. In this study, we tested the hypothesis that desflurane effects local estrogen synthesis by modulating enzyme aromatase expression and activity in the mouse heart. Aromatase metabolizes testosterone to 17b- estradiol (E2) and thereby significantly contributes to local estrogen synthesis. We tested aromatase effects in acute myocardial infarction model in male mice. The animals were randomized and subjected to four groups which were pre-treated with the selective aromatase inhibitor anastrozole (A group) and DES alone (DES group) or in combination (A+DES group) for 15 minutes prior to surgical intervention whereas the control group received 0.9% NaCl (CON group). All animals were subjected to 45 minutes ischemia following 180 minutes reperfusion. Anastrozole blocked DES induced preconditioning and increased infarct size compared to DES alone (37.94615.5% vs. 17.163.62%) without affecting area at risk and systemic hemodynamic parameters following ischemia/reperfusion. Protein localization studies revealed that aromatase was abundant in the murine cardiovascular system with the highest expression levels in endothelial and smooth muscle cells. Desflurane application at pharmacological concentrations efficiently upregulated aromatase expression in vivo and in vitro. We conclude that desflurane efficiently regulates aromatase expression and activity which might lead to increased local estrogen synthesis and thus preserve cellular integrity and reduce cardiac damage in an acute myocardial infarction model.
Background
We aimed to accurately estimate the frequency of a hexanucleotide repeat expansion in C9orf72 that has been associated with a large proportion of cases of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD).
Methods
We screened 4448 patients diagnosed with ALS (El Escorial criteria) and 1425 patients with FTD (Lund-Manchester criteria) from 17 regions worldwide for the GGGGCC hexanucleotide expansion using a repeat-primed PCR assay. We assessed familial disease status on the basis of self-reported family history of similar neurodegenerative diseases at the time of sample collection. We compared haplotype data for 262 patients carrying the expansion with the known Finnish founder risk haplotype across the chromosomal locus. We calculated age-related penetrance using the Kaplan-Meier method with data for 603 individuals with the expansion.
Findings
In patients with sporadic ALS, we identified the repeat expansion in 236 (7·0%) of 3377 white individuals from the USA, Europe, and Australia, two (4·1%) of 49 black individuals from the USA, and six (8·3%) of 72 Hispanic individuals from the USA. The mutation was present in 217 (39·3%) of 552 white individuals with familial ALS from Europe and the USA. 59 (6·0%) of 981 white Europeans with sporadic FTD had the mutation, as did 99 (24·8%) of 400 white Europeans with familial FTD. Data for other ethnic groups were sparse, but we identified one Asian patient with familial ALS (from 20 assessed) and two with familial FTD (from three assessed) who carried the mutation. The mutation was not carried by the three Native Americans or 360 patients from Asia or the Pacific Islands with sporadic ALS who were tested, or by 41 Asian patients with sporadic FTD. All patients with the repeat expansion had (partly or fully) the founder haplotype, suggesting a one-off expansion occurring about 1500 years ago. The pathogenic expansion was non-penetrant in individuals younger than 35 years, 50% penetrant by 58 years, and almost fully penetrant by 80 years.
Interpretation
A common Mendelian genetic lesion in C9orf72 is implicated in many cases of sporadic and familial ALS and FTD. Testing for this pathogenic expansion should be considered in the management and genetic counselling of patients with these fatal neurodegenerative diseases.
Local axonal function of STAT3 rescues axon degeneration in the pmn model of motoneuron disease
(2012)
Axonal maintenance, plasticity, and regeneration are influenced by signals from neighboring cells, in particular Schwann cells of the peripheral nervous system. Schwann cells produce neurotrophic factors, but the mechanisms by which ciliary neurotrophic factor (CNTF) and other neurotrophic molecules modify the axonal cytoskeleton are not well understood. In this paper, we show that activated signal transducer and activator of transcription-3 (STAT3), an intracellular mediator of the effects of CNTF and other neurotrophic cytokines, acts locally in axons of motoneurons to modify the tubulin cytoskeleton. Specifically, we show that activated STAT3 interacted with stathmin and inhibited its microtubule-destabilizing activity. Thus, ectopic CNTF-mediated activation of STAT3 restored axon elongation and maintenance in motoneurons from progressive motor neuronopathy mutant mice, a mouse model of motoneuron disease. This mechanism could also be relevant for other neurodegenerative diseases and provide a target for new therapies for axonal degeneration.
Background
Empirical studies investigating the prevalence of mental disorders and psychological distress in cancer patients have gained increasing importance during recent years, particularly with the objective to develop and implement psychosocial interventions within the cancer care system. Primary purpose of this epidemiological cross-sectional multi-center study is to detect the 4-week-, 12-month-, and lifetime prevalence rates of comorbid mental disorders and to further assess psychological distress and psychosocial support needs in cancer patients across all major tumor entities within the in- and outpatient oncological health care and rehabilitation settings in Germany.
Methods/Design
In this multicenter, epidemiological cross-sectional study, cancer patients across all major tumor entities will be enrolled from acute care hospitals, outpatient cancer care facilities, and rehabilitation centers in five major study centers in Germany: Freiburg, Hamburg, Heidelberg, Leipzig and Würzburg. A proportional stratified random sample based on the nationwide incidence of all cancer diagnoses in Germany is used. Patients are consecutively recruited in all centers. On the basis of a depression screener (PHQ-9) 50% of the participants that score below the cutoff point of 9 and all patients scoring above are assessed using the Composite International Diagnostic Interview for Oncology (CIDI-O). In addition, all patients complete validated questionnaires measuring emotional distress, information and psychosocial support needs as well as quality of life.
Discussion
Epidemiological data on the prevalence of mental disorders and distress provide detailed and valid information for the estimation of the demands for the type and extent of psychosocial support interventions. The data will provide information about specific demographic, functional, cancer- and treatment-related risk factors for mental comorbidity and psychosocial distress, specific supportive care needs and use of psychosocial support offers.
Background
Oncolytic viruses, including vaccinia virus (VACV), are a promising alternative to classical mono-cancer treatment methods such as surgery, chemo- or radiotherapy. However, combined therapeutic modalities may be more effective than mono-therapies. In this study, we enhanced the effectiveness of oncolytic virotherapy by matrix metalloproteinase (MMP-9)-mediated degradation of proteins of the tumoral extracellular matrix (ECM), leading to increased viral distribution within the tumors.
Methods
For this study, the oncolytic vaccinia virus GLV-1h255, containing the mmp-9 gene, was constructed and used to treat PC-3 tumor-bearing mice, achieving an intra-tumoral over-expression of MMP-9. The intra-tumoral MMP-9 content was quantified by immunohistochemistry in tumor sections. Therapeutic efficacy of GLV-1h255 was evaluated by monitoring tumor growth kinetics and intra-tumoral virus titers. Microenvironmental changes mediated by the intra-tumoral MMP-9 over-expression were investigated by microscopic quantification of the collagen IV content, the blood vessel density (BVD) and the analysis of lymph node metastasis formation.
Results
GLV-1h255-treatment of PC-3 tumors led to a significant over-expression of intra-tumoral MMP-9, accompanied by a marked decrease in collagen IV content in infected tumor areas, when compared to GLV-1h68-infected tumor areas. This led to considerably elevated virus titers in GLV-1h255 infected tumors, and to enhanced tumor regression. The analysis of the BVD, as well as the lumbar and renal lymph node volumes, revealed lower BVD and significantly smaller lymph nodes in both GLV-1h68- and GLV-1h255- injected mice compared to those injected with PBS, indicating that MMP-9 over-expression does not alter the metastasis-reducing effect of oncolytic VACV.
Conclusions
Taken together, these results indicate that a GLV-1h255-mediated intra-tumoral over-expression of MMP-9 leads to a degradation of collagen IV, facilitating intra-tumoral viral dissemination, and resulting in accelerated tumor regression. We propose that approaches which enhance the oncolytic effect by increasing the intra-tumoral viral load, may be an effective way to improve therapeutic outcome.
Electrophysiological analyses conducted about 25 years ago detected two types of anion channels in the plasma membrane of guard cells. One type of channel responds slowly to changes in membrane voltage while the other responds quickly. Consequently, they were named SLAC, for SLow Anion Channel, and QUAC, for QUick Anion Channel. Recently, genes SLAC1 and QUAC1/ALMT12, underlying the two different anion current components, could be identified in the model plant Arabidopsis thaliana. Expression of the gene products in Xenopus oocytes confirmed the quick and slow current kinetics. In this study we provide an overview on our current knowledge on slow and quick anion channels in plants and analyze the molecular evolution of ALMT/QUAC-like and SLAC-like channels. We discovered fingerprints that allow screening databases for these channel types and were able to identify 192 (177 non-redundant) SLAC-like and 422 (402 non-redundant) ALMT/QUAC-like proteins in the fully sequenced genomes of 32 plant species. Phylogenetic analyses provided new insights into the molecular evolution of these channel types. We also combined sequence alignment and clustering with predictions of protein features, leading to the identification of known conserved phosphorylation sites in SLAC1-like channels along with potential sites that have not been yet experimentally confirmed. Using a similar strategy to analyze the hydropathicity of ALMT/QUAC-like channels, we propose a modified topology with additional transmembrane regions that integrates structure and function of these membrane proteins. Our results suggest that cross-referencing phylogenetic analyses with position-specific protein properties and functional data could be a very powerful tool for genome research approaches in general.