Refine
Has Fulltext
- yes (337)
Is part of the Bibliography
- yes (337) (remove)
Year of publication
- 2023 (337) (remove)
Document Type
- Journal article (337) (remove)
Language
- English (337) (remove)
Keywords
- machine learning (11)
- deep learning (9)
- COVID-19 (6)
- anxiety (6)
- inflammation (5)
- mental health (5)
- Candida albicans (4)
- Germany (4)
- SARS-CoV-2 (4)
- Sentinel-2 (4)
- animal behaviour (4)
- artificial intelligence (4)
- climate change (4)
- global warming (4)
- human behaviour (4)
- mRNA (4)
- metabolism (4)
- neuroscience (4)
- psychology (4)
- quality of life (4)
- virtual reality (4)
- EEG (3)
- Parkinson's disease (3)
- altitudinal gradient (3)
- black holes (3)
- breast cancer (3)
- cancer (3)
- diagnosis (3)
- global change (3)
- heart failure (3)
- mortality (3)
- neuroimmunology (3)
- neuroinflammation (3)
- prognosis (3)
- remote sensing (3)
- surgery (3)
- toe (3)
- translational research (3)
- winter wheat (3)
- 3D printing (2)
- Alps (2)
- CD117 (2)
- CORDEX Africa (2)
- COVID-19 pandemic (2)
- Deep learning (2)
- Google Earth Engine (2)
- Merkel cell carcinoma (2)
- NK cells (2)
- NLRP3 (2)
- RNA (2)
- Sentinel-1 (2)
- Zambia (2)
- abandonment (2)
- accretion (2)
- adrenal tumours (2)
- amino acid transporter (2)
- angiogenesis (2)
- animal model (2)
- apoptosis (2)
- basic mental models (2)
- biomarker (2)
- blood gas analysis (2)
- bone (2)
- cancer microenvironment (2)
- cell biology (2)
- critical illness (2)
- cytokines (2)
- decision making (2)
- decision-making (2)
- deep brain stimulation (2)
- depression (2)
- diseases of the nervous system (2)
- eHealth (2)
- earth observation (2)
- editorial (2)
- education for sustainable healthcare (2)
- endoscopy (2)
- extracellular vesicles (2)
- gene expression (2)
- general relativity (2)
- genetics (2)
- genomics (2)
- glioblastoma (2)
- grading (2)
- health policy (2)
- imaging (2)
- immunotherapy (2)
- infection (2)
- insulin resistance (2)
- local field potentials (2)
- mathematical modelling (2)
- medical education (2)
- methodological pluralism (2)
- neural network (2)
- neurological disorders (2)
- neurology (2)
- neuromuscular junction (2)
- obesity (2)
- object detection (2)
- oncology (2)
- organoids (2)
- osteoporosis (2)
- oxidative stress (2)
- permafrost (2)
- photon-counting (2)
- polyomavirus (2)
- preclinical research (2)
- preterm infants (2)
- protease inhibitors (2)
- protein kinase (2)
- radiotherapy (RT) (2)
- reconstruction (2)
- recovery (2)
- relativistic jets (2)
- renewable energy (2)
- replication crisis (2)
- sepsis (2)
- signaling pathway (2)
- software (2)
- sphingolipids (2)
- spinal muscular atrophy (2)
- spine (2)
- stress (2)
- stroke (2)
- survival (2)
- sustainable agriculture (2)
- technology (2)
- the rich (2)
- three-dimensional imaging (2)
- tissue engineering (2)
- tomography (2)
- topological insulators (2)
- transcriptome (2)
- transformative education (2)
- tumor microenvironment (2)
- urbanization (2)
- very-long-baseline interferometry (2)
- vitamin C (2)
- vitamin D (2)
- wind speed (2)
- (approximate) functional equation (1)
- 1,2-azaborinine (1)
- 223Ra (1)
- 224Ra (1)
- 2ϕ\(_0\) periodicity (1)
- 3D cell culture (1)
- 3D in vitro model (1)
- 3D model generation (1)
- 3D organoids (1)
- 3D tissue model (1)
- 4D-GIS (1)
- 77-LH-28-1 (1)
- A. thaliana (1)
- ACC/AHA classification (1)
- AGP (1)
- AMPK (1)
- ATPase activity (1)
- Ableitung (1)
- Achilles tendinopathy (1)
- Agrobacterium (1)
- Aldehyde Bioconjugation (1)
- Alkyltransferase Ribozyme SAMURI (1)
- Allorhizobium vitis (1)
- AmGr1 (1)
- AmGr2 (1)
- AmGr3 (1)
- American Thyroid Association (1)
- Analytical Quality by Design (1)
- Apis mellifera (1)
- Argentina (1)
- Asc-1 transporter (1)
- BPM (1)
- BPMN (1)
- Bioorthogonal Tag (1)
- Boron (1)
- Borylation (1)
- Brassicaceae (1)
- C1q/TNF related protein (CTRP) (1)
- C5a (1)
- C5aR1 (1)
- CAR-T cells (1)
- CCR2 (1)
- CCR4 (1)
- CIED malfunction; pacemaker (PM) (1)
- CK5 (1)
- CNS disorders (1)
- CNS integrity (1)
- CNV (1)
- COVID‐19 (1)
- CPFE (1)
- CRISPR/Cas9 (1)
- CXCL10 (1)
- CXorf44 (1)
- Calu-3 (1)
- Cambrian (1)
- Candida auris (1)
- Carbene (1)
- Cas9 (1)
- Cayley graph (1)
- Chemical modification (1)
- Chinese state media (1)
- Cognitive Remediation (1)
- Concealed Information Test (CIT) (1)
- Covid-19 (1)
- Cox proportional regression analysis (1)
- DAS28 (1)
- DASH (1)
- DBS biomarkers (1)
- DBS programming (1)
- DEUQUA (1)
- DMARD (1)
- DNA (1)
- DNA damage repair (1)
- DNA methylation (1)
- DNA recognition (1)
- DNA storage (1)
- Diboryne (1)
- Drosophila melanogaster (1)
- EGFR (1)
- EHT (1)
- EUROASPIRE (1)
- Earth observation (1)
- Echinococcus (1)
- Enterococcus faecalis (1)
- Enterococcus faecium (1)
- European orchard bee (Osmia cornuta) (1)
- FAM104A (1)
- FAM104B (1)
- FFPE (1)
- FLJ14775 (1)
- FLJ20434 (1)
- FTIR spectroscopy (1)
- Fabaceae (1)
- Fluorescence and Crosslinking (1)
- Fn14 (1)
- Förster Resonance Energy Transfer (1)
- GEDI (1)
- GIS (1)
- GPVI (1)
- GRAPPA (1)
- GSK3 (1)
- German population (1)
- Global Ecosystem Dynamics Investigation (1)
- Glut1DS (1)
- Grad-seq (1)
- Gram points (1)
- Gram’s law (1)
- Graptolithoidea (1)
- Graßmannians (1)
- Grundvorstellung (1)
- HAQ (1)
- HCW (1)
- HER2 conversion (1)
- HER2 targeted therapy (1)
- HER2-low (1)
- HNSCC (1)
- HPβCD (1)
- Hecke L-functions (1)
- Hecke eigenforms (1)
- Hurwitz zeta function (1)
- Hydroarylation (1)
- ICM cells (1)
- IFNG (1)
- IL-4 antagonists (1)
- ILEX (1)
- IR spectroscopy (1)
- IT security (1)
- Interleukin-4 (IL-4) (1)
- IoT (1)
- IoT-driven processes (1)
- JOL reactivity (1)
- Janus fibers (1)
- Josephson junctions (1)
- Journal of Nuclear Cardiology (1)
- K band ranging (KBR) (1)
- KEA (1)
- KIT (1)
- KhpB protein (1)
- Ki67 (1)
- Klima (1)
- LCNEC (1)
- LPS (1)
- LUMEN (1)
- Land Use/Land Cover (1)
- Landsat 8 (1)
- LeishBASEedit (1)
- Leishmania (1)
- Lepidoptera (1)
- Lerch zeta function (1)
- Lewis acidity (1)
- Lie group actions (1)
- Lie groups (1)
- Lie n-algebroids (1)
- MATQ-seq (1)
- MGL (1)
- MOD13Q1 (1)
- MODIS (1)
- MSC 11M35 (1)
- MSC: 14M15 (1)
- MSC: 49M37 (1)
- MSC: 53C22 (1)
- MSC: 53C35 (1)
- MSC: 65K05 (1)
- MSC: 90C30 (1)
- MSC: 90C40 (1)
- MYCNv (1)
- Mamestra brassicae (1)
- Mc4r (1)
- Mig1 (1)
- Modell (1)
- Multiple Myeloma (1)
- N ligands (1)
- N-functionalization (1)
- N-heterocyclic carbenes (1)
- NAFLD (1)
- NAS (1)
- NDVI (1)
- NF-κB (1)
- NGS (1)
- NHX1 (1)
- NMDAR (1)
- NMJ–neuromuscular junction (1)
- NOTCH (1)
- NaCl transport (1)
- Neisseria gonorrhoeae (1)
- Neuronales Netz (1)
- Norbert Groeben (1)
- OLFM4 (1)
- Oldenburg burnout inventory (1)
- PAH formation (1)
- PCLS (1)
- PCR (1)
- PFA in ethanol (1)
- PROM’s (1)
- PSMC2 (1)
- PSP (1)
- Parkinson’s disease (1)
- Planetary Health (1)
- Planetary Health Education (1)
- Poisson algebras (1)
- QuantiFERON\(^®\)-TB Gold Plus (1)
- RAKI (1)
- RCC (1)
- RCK domain (1)
- RCT (1)
- RNA Labelling (1)
- RNA recognition (1)
- RNA transport (1)
- RNA-binding proteins (1)
- RT-qPCR (1)
- Rheumatoid Arthritis (1)
- Ribozyme (1)
- Roux-en-Y Gastric Bypass (1)
- Ruthenium complexes (1)
- SAH (1)
- SCCHN (1)
- SLC-family (1)
- SNF1 (1)
- Salmonella Typhimurium (1)
- Salmonella enterica (1)
- Salt Overly Sensitive pathway (1)
- Shannon entropy (1)
- Site-specific RNA labelling (1)
- Socrates (1)
- South Indian Ocean (1)
- Structure-from-Motion (1)
- Struktur (1)
- T antigen (1)
- T cells (1)
- T-Track\(^®\) TB (1)
- T-cell lymphoma (1)
- T-shaped π–π stacking (1)
- TB (1)
- TKA (1)
- TNF (1)
- TNFR1 (1)
- TNFR2 (1)
- TNFα (1)
- TRAF2 (1)
- TWEAK (1)
- Tamoxifen (1)
- Testinstrument (1)
- Ti plasmids (1)
- Toll-like receptor signaling (1)
- Tumor Treating Fields (TTFields) (1)
- Tumor-Treating Fields (TTFields) (1)
- Ureaplasma parvum (1)
- Venezuela (1)
- Vero E6 (1)
- Vicia faba (L.) (1)
- Vitis vinifera (1)
- Volatile Organic Compound (VOC) (1)
- Wechsler intelligence scale (WISC-IV) (1)
- West African refugee crisis (1)
- West Gondwana (1)
- Western Europe (1)
- WhatsApp (1)
- X-ray computed (1)
- Xanomeline (1)
- Xinjiang (1)
- Xiphophorus (1)
- YAP5SA (1)
- YouTube (1)
- Ypk1 (1)
- \(^1\)H-NMR spectroscopy (1)
- abdominal imaging (1)
- acid value (1)
- action control (1)
- action prepotency (1)
- active TB (1)
- active galactic nuclei (1)
- active zone (1)
- adaptive intervention competence (1)
- addiction (1)
- adiponectin (1)
- adjoint and coadjoint representations (1)
- adjuvant therapy (1)
- adolescence (1)
- adrenal imaging (1)
- adrenocortical carcinoma (ACC) (1)
- adverse drug reaction (1)
- adverse effects (1)
- affluence (1)
- age (1)
- age determination by skeleton (1)
- aggression (1)
- algebraic degree (1)
- algorithms (1)
- alternating management (1)
- alternative pig farming (1)
- alveolar bone loss (1)
- amber light (1)
- amino acid restriction (1)
- anaemia (1)
- anaesthesiology (1)
- anatomy (1)
- anchoring (1)
- anesthesia (1)
- anesthesiology (1)
- animal models (1)
- animal physiology (1)
- annotation (1)
- antenna phase center calibration (1)
- anthropomorphism (1)
- anti-thrombotic therapies (1)
- anti-tumor agents (1)
- antidepressants (1)
- antifungal drug (1)
- antigen-presenting cells (1)
- antimicrobial resistance (1)
- antimicrobial responses (1)
- antioxidant (1)
- antivirals (1)
- aortic valve stenosis (1)
- apexification (1)
- aqueous humor outflow (1)
- aromaticity (1)
- arousal inhibition (1)
- arthroscopic simulator training (1)
- artificial photosynthesis (1)
- assembloid (1)
- atopic diseases (1)
- atrial fibrillation (1)
- attention (1)
- auditory pathway (1)
- autobiographical memory (1)
- automation (1)
- autonomic (1)
- autonomous cortisol secretion (1)
- autophagy (1)
- availability (1)
- axial vascularization (1)
- axons (1)
- azapeptide nitriles (1)
- azido-ceramides (1)
- azobenzenes (1)
- background knowledge (1)
- bacterial community (1)
- bacterial migration (1)
- bacterial virulence (1)
- baseline detection (1)
- battery depletion (1)
- bee (1)
- bees (1)
- behaviometric (1)
- behavior (1)
- beta power (1)
- bilateral motor network (1)
- bioceramic (1)
- biocompatible materials (1)
- biodiversity conservation (1)
- biodosimetry (1)
- bioelectronics (1)
- bioinorganic (1)
- biological scaffold (1)
- biomedical engineering (1)
- bioorthogonal SAM analogue ProSeDMA (1)
- biostratigraphy (1)
- biosynthetic glycosylation (1)
- bipartite metabolism (1)
- bipolar disorder (1)
- bitopic hybrid ligands (1)
- blended learning (1)
- blockchain anchoring (1)
- blockchain in healthcare (1)
- blockchain in the pharmaceutical industry (1)
- blockchain interoperability (1)
- blood platelets (1)
- blood vessel (1)
- blood-brain barrier (1)
- body size (1)
- bond activation (1)
- bond theory (1)
- bone conduction implant (1)
- bone imaging (1)
- bone metabolism (1)
- bone morphogenetic protein 9 (BMP9) (1)
- bone morphogenetic proteins (1)
- bone regeneration (1)
- boraselenone (1)
- borirane (1)
- boundary spanning (1)
- brain (1)
- brain endothelium (1)
- brain signal complexity (1)
- branched-chain amino acids (1)
- breast cancer imaging (1)
- breed predisposition (1)
- built environment (1)
- burnout (1)
- business process anagement (1)
- c-kit (1)
- calcium channels (1)
- calcium phosphate (1)
- calcium signaling (1)
- caloric restriction (1)
- calorimetry (1)
- calprotectin (1)
- camera orientation (1)
- cancellous bone (1)
- cancer immunotherapy (1)
- candidate gene (1)
- canine (1)
- canola (1)
- canopy height (1)
- capillary electrophoresis (1)
- carbon dioxide (CO2) (1)
- carborane (1)
- carcinoma (1)
- cardiac arrest (1)
- cardiac implantable electronic devices (CIED) (1)
- cardiac resynchronization therapy (CRT) (1)
- cardiology (1)
- cardioprotective potential (1)
- cardiovascular MRI (1)
- cardiovascular diseases (1)
- cardiovascular events (1)
- cardiovascular risk factors (1)
- caregiver (1)
- caregiver burden (1)
- catalase (1)
- catholicism (1)
- causality (1)
- cell cycle (1)
- cell differentiation patterns (1)
- cell line specificity pyridyl indole carboxylates (1)
- cell line-specificity (1)
- cell migration (1)
- cell velocimetry (1)
- cell vitality (1)
- cellular physiology (1)
- cellular signalling networks (1)
- central bank information (1)
- central complex (1)
- cephalometry (1)
- ceramides (1)
- cerebrovascular disorders (1)
- change vector analysis (1)
- charged aerosol detector (1)
- chemical bonding (1)
- chemical ecology (1)
- chemical glycosylation (1)
- chemical libraries (1)
- chemokine receptor (1)
- child development (1)
- children (1)
- chlorantraniliprole (1)
- chromatin (1)
- chronic kidney disease (1)
- circadian rhythm (1)
- circular dichroism (1)
- circulating (1)
- circulation types (1)
- circum-Arctic (1)
- cisplatin (1)
- classification (1)
- climate (1)
- climate policy (1)
- climate resilience (1)
- climate‐smart pest management (1)
- clinical decision support (1)
- clinical measurement in health technology (1)
- clinical outcome (1)
- clinical skills (1)
- clinical systems (1)
- co-culture (1)
- coastal erosion (1)
- cocoa mapping (1)
- cognitive ability (1)
- cognitive bias (1)
- cognitive deficits (1)
- cognitive impairment (1)
- cognitive load (1)
- cognitive neuroscience (1)
- cognitive profile (1)
- cognitive remediation (1)
- coherence (1)
- collagen (1)
- color (1)
- colorectal cancer (1)
- combination (1)
- commensal bacteria (1)
- communication models (1)
- communication networks (1)
- comorbidity (1)
- comparability (1)
- complementary medicine (1)
- complex‐valued machine learning (1)
- computational chemistry (1)
- computational neural networks (1)
- computed tomography (1)
- computer modelling (1)
- computer navigation (1)
- computer vision (1)
- computer-aided (1)
- conditionality (1)
- conservation biology (1)
- content-based image retrieval (1)
- control group (1)
- conventional imaging (1)
- convolution kernel (1)
- cooperation (1)
- coordination chemistry (1)
- cord blood (1)
- coronary artery disease (1)
- coronary heart disease (1)
- covalent inhibitors (1)
- covert retrieval (1)
- crop modeling (1)
- crop models (1)
- crop rotation (1)
- cross-sectional imaging (1)
- crystallographic analyses (1)
- cue availability (1)
- cue exposure therapy (1)
- cue reactivity (1)
- cultural diversity (1)
- curriculum development (1)
- cutaneous lymphomas (1)
- cuticular hydrocarbon (1)
- cutting (1)
- cyclic alkyl(amino)carbenes (1)
- cyclodextrins (1)
- cytochrome P450s (1)
- cytosine base editor (CBE) toolbox (1)
- cytoskeleton (1)
- cytosolic pH (1)
- cytotoxic T cells (1)
- cytotoxicity (1)
- dSTORM (1)
- damage control orthopedics (1)
- data analysis (1)
- data augmentation (1)
- data display (1)
- data storage (1)
- data warehouse (1)
- dataset (1)
- ddPCR (1)
- de Casteljau Algorithm (1)
- de novo sequenced genomes (1)
- decafluoroazobezene (1)
- decay (1)
- delay of therapy (1)
- deliberation (1)
- dementia (1)
- dens invaginatus (1)
- density functional calculations (1)
- dental education (1)
- derivative (1)
- dermal fibroblasts (1)
- desiccation (1)
- design (1)
- design of experiments (1)
- developmental biology (1)
- dexamethasone (1)
- dexamethasone suppression test (1)
- diabetes mellitus (1)
- diagnostic correctness (1)
- diagnostic markers (1)
- diagnostics (1)
- dialysis adequacy (1)
- dicoordinate borylene (1)
- differential expression (1)
- differential graded modules (1)
- differentiated thyroid cancer (1)
- digit (1)
- digital Health (1)
- digital age (1)
- digital medicine (1)
- digital tools (1)
- discourse analysis (1)
- discriminant analysis (1)
- disease score (1)
- disease severity (1)
- diseases (1)
- disengagement (1)
- dishonest responding (1)
- disorder of immunity (1)
- doctoral graduates (1)
- dog (1)
- dormancy (1)
- dosimetry (1)
- drift-diffusion modeling (1)
- drought stress (1)
- drug resistance (1)
- drug safety (1)
- dual action benefits (1)
- dual-energy CT (1)
- dual-source CT (1)
- dust microbiomes (1)
- dynamic protein-protein interactions (1)
- dynamics (1)
- dystonia (1)
- e-Learning (1)
- early breast cancer (1)
- echinococcosis (1)
- echinocytes (1)
- eco health (1)
- ecology (1)
- ecosystem function (1)
- edge states (1)
- education (1)
- electrical and electronic engineering (1)
- electrocution (1)
- electromyography (1)
- electronic health records (1)
- electronic properties and materials (1)
- electroporation (1)
- emergency information (1)
- emotion (1)
- emotion regulation (1)
- emphysema (1)
- enantiomers (1)
- end-stage kidney disease (1)
- endoglin (1)
- endoscopic instruments (1)
- endoscopic intervention (1)
- endpoint geodesics (1)
- entomology (1)
- environmental health (1)
- environmental impact (1)
- ephedrine (1)
- epidemiology (1)
- epigenetic modification (1)
- episodic binding (1)
- epitope mapping (1)
- error (1)
- error processing (1)
- error-transfer (1)
- ester value (1)
- eudaimonia (1)
- euglena (1)
- euglenids (1)
- evidence synthesis (1)
- evidence-based policy (1)
- evidence-based practice (1)
- evolutionary developmental biology (1)
- evolutionary genetics (1)
- exchange rate dynamics (1)
- exemplarity (1)
- exercise (1)
- exhaustion (1)
- experimental models of disease (1)
- explainability of machine learning (1)
- exponent pairs (1)
- exponential growth (1)
- extracellular (1)
- eye movement disorders (1)
- fNIRS (1)
- fatigue (1)
- fatty acids (1)
- fear (1)
- feature analysis (1)
- feature matching (1)
- feature selection (1)
- fecal short-chain fatty acids (1)
- feeding (1)
- femoral fracture (1)
- fiber intake (1)
- fibrin (1)
- fibula (1)
- filamentous Salmonella Typhimurium (1)
- fitness trackers (1)
- fixation (1)
- flowering plants (1)
- flowers (1)
- fluorescence lifetime imaging microscopy (1)
- fluorescence resonance energy transfer (1)
- fluorescent probe (1)
- fluoroscopy (1)
- focus of infection (1)
- folded macrocyles (1)
- follow-up (1)
- force (1)
- forest (1)
- forest structure Germany (1)
- formalin (1)
- fracture (1)
- free electron laser (1)
- free jet (1)
- free light chains (1)
- fully convolutional neural networks (1)
- fused boracycles (1)
- fusion (1)
- gait-phase prediction (1)
- game layers (1)
- gammadelta T cells (1)
- gastroenterology (1)
- gastrointestinal (1)
- gene (1)
- gene editing (1)
- gene expression heterogeneity (1)
- general circulation model (1)
- general practice (1)
- genetic engineering (1)
- genotoxicity (1)
- genotypes (1)
- geographically weighted regression (1)
- germanium (1)
- giant cell arteritis (1)
- global (action-inherent) (1)
- globus pallidus (1)
- glycine receptor (1)
- glycine uptake (1)
- glycoengineering (1)
- glycogen synthase kinase 3 (1)
- good clinical practice (1)
- graft (1)
- gram-negative bacteria (1)
- grasshopper (1)
- grazing (1)
- group-based communication (1)
- growth cone (1)
- growth models (1)
- guideline-directed medical therapy (1)
- gustatory receptors (Grs) (1)
- haircoat (1)
- halogenation (1)
- hand dominance (1)
- head and neck cancer (1)
- health care (1)
- health sciences (1)
- health-care workers (1)
- health-related quality of life (1)
- healthcare assistants (1)
- hearing aids (1)
- heart (1)
- heart rate (1)
- heat transfer (1)
- hematoma (1)
- hemodialysis (1)
- hemoglobin jet (1)
- hemolymph lipids (1)
- heparin binding sites (1)
- herpes virus (1)
- heuristics (1)
- high-frequency identification (1)
- high-pressure freezing/freeze substitution (1)
- historical document analysis (1)
- historical images (1)
- historical psychology (1)
- history of psychology (1)
- home isolation (1)
- homeostasis (1)
- homogeneous catalysis (1)
- honeybee taste perception (1)
- hospital data (1)
- hospitalization (1)
- human (1)
- human brain microvascular endothelial cells (HBMVEC) (1)
- human cells (1)
- human induced pluripotent stem cells (1)
- human learning (1)
- human startle disease (1)
- human–computer interaction (1)
- hybrid materials (1)
- hydrides (1)
- hymenoptera (1)
- hypertension (1)
- hypoxia (1)
- iPSC (induced pluripotent stem cells) (1)
- illness experience (1)
- immature tooth (1)
- immaturity (1)
- immune cell infiltration (1)
- immune infiltration (1)
- immunofluorescence (1)
- immunogenetics (1)
- immunoglobulin rearrangement (1)
- immunology (1)
- immunomodulation (1)
- immunosurveillance (1)
- implantable cardioverter defibrillator (ICD) (1)
- implementation framework (1)
- implications of wealth (1)
- impression formation (1)
- in silico analysis (1)
- in vitro and in vivo thrombus formation (1)
- in vitro dissolution methods (1)
- in vitro dissolution testing (1)
- in vitro study (1)
- in vivo dissolution (1)
- inappropriate medication (1)
- inbound medical tourism (1)
- inclusive education (1)
- income wealth threshold estimations (1)
- individual drug responses (1)
- individual mind state (1)
- indoxacarb (1)
- inertial measurement units (1)
- infection detection (1)
- inflammasome (1)
- infodemic (1)
- informal education (1)
- information extraction (1)
- information strategies (1)
- inhibition failures (1)
- innate immunity (1)
- insect conservation (1)
- insecticide (1)
- instrument design (1)
- insulin receptor (1)
- integral graph (1)
- intelligence (1)
- intelligent voice assistant (1)
- intensity analysis (1)
- interactivity (1)
- interference pattern (1)
- interferometry (1)
- internal medicine (1)
- intervention strategies (1)
- interview study (1)
- intestinal enteroids (1)
- intestinal inflammation (1)
- intestinal permeability (1)
- intramuscular hemorrhage (1)
- intratumoral microbiota (1)
- iodine value (1)
- ipsilateral motor evoked potential (1)
- ipsilateral motor network (1)
- irony (1)
- ischemia (1)
- ischemic stroke (1)
- job satisfaction (1)
- judgement (1)
- judgments of learning (1)
- ketamine (1)
- ketogenic dietary therapy (KDT) (1)
- key-insight extraction (1)
- kidney cancer (1)
- kinase signaling (1)
- knee arthroplasty (1)
- knee replacement (1)
- laboratory and online studies (1)
- lactation (1)
- land surface temperature (1)
- land-use intensification (1)
- landsat (1)
- landscape complexity (1)
- large T antigen (1)
- large animal models (1)
- large‐scale atmospheric circulation modes (1)
- lateral neck abscesses (1)
- layered dissection (1)
- layout recognition (1)
- leaf response (1)
- learning (1)
- learning and memory (1)
- length of stay (1)
- level of evidence III (1)
- lidar (1)
- lifestyle habits (1)
- ligands (1)
- light-driven metabolism (1)
- lipidomics (1)
- livestock-associated staphylococci (1)
- local (transient) (1)
- local cell neighborhood (1)
- local self‐governance (1)
- locomotor activity (1)
- long-term analysis (1)
- long-term survivors (1)
- low back pain (1)
- low energy metabolism (1)
- lower extremity (1)
- lower extremity amputation (1)
- lung fibrosis (1)
- lying (1)
- lying behavior (1)
- lymph node (1)
- lymph nodes (1)
- lymphatic metastasis (1)
- lymphocyte differentiation (1)
- mHealth (1)
- magnesium stearate (1)
- magnetic resonance imaging (1)
- main group elements (1)
- major amputation (1)
- major depressive disorder (MDD) (1)
- management (1)
- mandibular (1)
- manufacturing (CAD/CAM) (1)
- marker (1)
- mathematics classrooms (1)
- mating strategies (1)
- maxillofacial surgery (1)
- meadow (1)
- mechanical alignment (1)
- mechanical thrombectomy (1)
- mechanism of action (1)
- media analysis (1)
- medical device training (1)
- medical devices (1)
- medical imaging (1)
- medical nutrition therapy (1)
- medical records (1)
- medium cut-off dialyzer (1)
- membrane transporters (1)
- mental disorders (1)
- mesenchymal stromal cells (1)
- mesodermal organoid (1)
- meta-data (1)
- metabolically unhealthy obesity (1)
- metabolomics (1)
- metacomprehension (1)
- metagenomics (1)
- metastasis (1)
- methionine (1)
- methodology (1)
- miR (1)
- miRNA (1)
- micro-CT (1)
- microRNA (1)
- microbial diversity (1)
- microbial ecology (1)
- microbiology (1)
- microbiota-derived metabolites (1)
- micrometre level microwave ranging (1)
- micronuclei (1)
- micronutrients (1)
- microscopy (1)
- microstates (1)
- middle cerebral artery occlusion (1)
- migration (1)
- mind-body-intervention (1)
- mindfulness (1)
- miniature schnauzer (1)
- minimally invasive surgery (1)
- minor amputation (1)
- misconceptions (1)
- mitochondrial calcium uniporter (1)
- mitotic disturbance (1)
- mixed methods (1)
- mobile instant messaging (1)
- mobile messaging application (1)
- mobility (1)
- model output statistics (1)
- model reduction (1)
- moisture convergence (1)
- molecular biology (1)
- molecular capsules (1)
- molecular evolution (1)
- molecular modelling (1)
- molecular neuroscience (1)
- monitoring (1)
- monocyte subsets (1)
- monocytes (1)
- monovalent cation:proton antiporter-2 (CPA2) family (1)
- morbidity (1)
- morphology (1)
- motivation (1)
- motivational level (1)
- motoneuron (MN) (1)
- motor neurons (1)
- mountain (1)
- mountain biodiversity (1)
- mouse blastocysts (1)
- mouse embryonic stem cells (1)
- mouse xenografts (1)
- movement disorder (1)
- multicentric (1)
- multidisciplinary (1)
- multilayer perceptron model (1)
- multimodal intervention (1)
- multiple action control (1)
- multiscale encoder (1)
- multisensory navigation (1)
- multi‐model ensemble (1)
- murine cytomegalovirus (MCMV) (1)
- muscarinic acetylcholine receptors (1)
- muscle (1)
- musculoskeletal system (1)
- museum practice (1)
- mushroom body (1)
- mutation (1)
- myelin biology and repair (1)
- myelination (1)
- myeloma (1)
- myocardial infarction (1)
- nanofibers (1)
- nanographene (1)
- nanotopology (1)
- natural processing (1)
- navigation (1)
- near-surface geophysics (1)
- necrobiome (1)
- necroptosis (1)
- neighborhood movement (1)
- neoadjuvant therapies (1)
- neonatal immunology (1)
- neonatal meningitis (1)
- network analysis (1)
- network simulation (1)
- neural crest (1)
- neural networks (1)
- neural organoid (1)
- neural stem cell potential (1)
- neuroblastoma cell (1)
- neuroendocrine tumor (1)
- neurofibromatosis type 1 (1)
- neuronal and synaptic plasticity (1)
- neuronavigation (1)
- neurosphere (1)
- neutrophils (1)
- new media (1)
- news media reporting (1)
- ngEHT (1)
- nifedipine (1)
- non-SBI fungicide (1)
- non-aureus staphylococci (1)
- non-cancer controls (1)
- non-fullerene acceptors (1)
- non-muscle myosin (1)
- non-small cell lung cancer (NSCLC) (1)
- non-small-cell lung (1)
- non‐fullerene acceptors (1)
- norepinephrine transporter (1)
- normal distribution transform (1)
- normal values (1)
- nuclear import (1)
- nursing home residents (1)
- nystagmus (1)
- obesity surgery (1)
- object reconstruction (1)
- ocular anterior segment perfusion culture (1)
- oculomotor (1)
- off-chain data (1)
- oil seed rape (1)
- oil-seed rape (1)
- oilseed rape (1)
- olfactomedin 4 (1)
- oncobiome (1)
- oncogenic YAP (1)
- oncologist (1)
- oncolytic virus (1)
- one-electron oxidation (1)
- one-health approach (1)
- ontology (1)
- opendsu (1)
- ophthalmic artery (1)
- optic nerve (1)
- optogenetics (1)
- oral bioavailability (1)
- oral drug absorption (1)
- oral squamous cell carcinoma (1)
- orbit (1)
- order of growth (1)
- organic farming (1)
- organic light emitting diodes (1)
- organic photovoltaics (1)
- organic solar cells (1)
- organoid (1)
- orienting response (1)
- oropharyngeal carcinoma (1)
- orthodontics (1)
- orthognathic surgery (1)
- orthopaedic surgery (1)
- orthopedic surgery (1)
- orthopedics (1)
- oscillation (1)
- osmotic effects (1)
- osteoarthritis (1)
- osteochondral lesion (1)
- osteocutaneous (1)
- ovarian cancer (1)
- ovarian tumor (1)
- ozone (O3) (1)
- p97 VCP Cdc48 (1)
- pN1 (1)
- pain (1)
- pancreatic cancer (1)
- pandemic (1)
- panel-sequencing (1)
- papillary thyroid carcinoma (PTC) (1)
- parallel imaging (1)
- parasitoid (1)
- parasitology (1)
- parental investment theory (1)
- parotid gland (1)
- partial knee arthroplasty (1)
- pasture (1)
- path indistinguishability (1)
- patient data (1)
- patient reported outcome measures (1)
- patient-specific implant (1)
- patient-specific instruments (1)
- patients' experience (1)
- pedagogical content knowledge (1)
- pedicle screws (1)
- people with disabilities (1)
- peptide stapling (1)
- peptidomimetic sequence (1)
- peptidomimetics (1)
- perception (1)
- perception and action (1)
- perfluoroarylation (1)
- performance (1)
- perfusion (1)
- perfusion culture (1)
- peripartum (1)
- peripheral nervous system (1)
- permanent employment (1)
- peroxisomes (1)
- personalized medicine (1)
- perylene bisimide dyes (1)
- pesticide mixture (1)
- pharmacovigilance (1)
- pharmaledger (1)
- phenomenology (1)
- phenotype (1)
- phosphatidylcholines (1)
- phospholipidosis (1)
- phosphoproteome (1)
- photocatalysis (1)
- photocontrol (1)
- phthalazinone pyrazole (1)
- phylogenetics (1)
- physical activity (1)
- physical therapy (1)
- physiological dataset (1)
- physiology (1)
- pig (1)
- pig farming methods (1)
- piquetero movement (1)
- planetary health (1)
- planetary health education (1)
- planning (1)
- plant development (1)
- plant molecular biology (1)
- plant physiology (1)
- plant signalling (1)
- plant-herbivore interactions (1)
- plant-insect interactions (1)
- plantaris tendinopathy (1)
- plant–herbivore interactions (1)
- platelet activation (1)
- platelet aggregation (1)
- platelet-derived growth factor (1)
- platelet-rich plasma (1)
- platelets (1)
- point-of-care (1)
- point-of-care-testing (1)
- policy cycle (1)
- policy lab (1)
- policy pilot (1)
- pollen beetle (1)
- pollinator (1)
- pollinators (1)
- pollution (1)
- polycyclic aromatic hydrocarbons (1)
- polymers (1)
- polyneuropathy (1)
- polypharmacy (1)
- polysorbate 80 (1)
- population-based (1)
- pore (1)
- pose tracking (1)
- positive nodal status (1)
- positron emission tomography (1)
- post-neoadjuvant therapies (1)
- postsynaptic potentials (1)
- posttranscriptional regulation (1)
- posture (1)
- potassium channel (1)
- potassium homeostasis (1)
- precision agriculture (1)
- precision medicine (1)
- precision-cut tumor slices (1)
- preclinical model (1)
- prediction (1)
- predictive process analytics (1)
- predictive process monitoring (1)
- preface (1)
- prefrontal cortex (1)
- pregnancy (1)
- prenatal paternal depression (1)
- preoperative (1)
- prescribing omission (1)
- preterm birth (1)
- prevalence (1)
- prevention (1)
- preventive medicine (1)
- primary care (1)
- principal (1)
- principal component analysis (1)
- private chat groups (1)
- proboscis extension response (PER) (1)
- process mining (1)
- prognostic marker (1)
- progression-free survival (1)
- project management (1)
- propeller flap (1)
- propofol (1)
- prospective (1)
- prospective study (1)
- proteasome inhibitors (1)
- proteasome system (1)
- protective behavior (1)
- protective factors (1)
- protein (1)
- protein analysis (1)
- protein binding (1)
- proteomics (1)
- proxy VAR (1)
- psychiatric rehabilitation (1)
- psycho-oncology (1)
- psychoeducation (1)
- psychological burden (1)
- psychometrics (1)
- psychopathology (1)
- psychotropic drugs (1)
- psychotropic medication (1)
- puberty (1)
- public health (1)
- pulmonary cancer (1)
- push-pull stabilization (1)
- pyrrolizidine alkaloids (1)
- qualitative methods (1)
- qualitative research (1)
- quality control (1)
- quality of care (1)
- quantitative 1H NMR (1)
- quantitative methods (1)
- quantum optics (1)
- rRNA depletion (1)
- radiation dose (1)
- radical reactions (1)
- radio astronomy (1)
- radiographic bone loss (1)
- radioiodine (1)
- radiology (1)
- radiotherapy (1)
- rainfall (1)
- random forest (1)
- random forest regression (1)
- randomized controlled trial (1)
- range shifts (1)
- ransomware (1)
- rapid prototyping (1)
- reactivity and selectivity study (1)
- real-time (1)
- real-world (1)
- reasoning (1)
- recognition (1)
- red fruit oil (1)
- reference data (1)
- reflections (1)
- regenerative cooling (1)
- regenerative medicine (1)
- regional climate model (1)
- regulation (1)
- regulatory T cells (1)
- rehabilitation (1)
- reinforcement learning (1)
- relationship duration (1)
- reliability (1)
- remitted/acute phase (1)
- reperfusion injury (1)
- replica (1)
- representations up to homotopy (1)
- reproductive disorders (1)
- research infrastructure (1)
- research integrity (1)
- resection (1)
- resilience (1)
- resolution (1)
- respiratory signs and symptoms (1)
- response fractionation (1)
- resting-state (1)
- restrained statehood (1)
- retrogressive thaw slump (1)
- review (1)
- revitalization (1)
- rheumatoid arthritis (1)
- rigidification (1)
- ring strain (1)
- risk pregnancy (1)
- risk stratification (1)
- robotic (1)
- robotic process automation (1)
- rocket engine (1)
- rodent model (1)
- rotations (1)
- rural (1)
- sRNA (1)
- sacubitril-valsartan (1)
- salivary gland neoplasia (1)
- salt metathesis (1)
- salt stress (1)
- salt-and-pepper pattern (1)
- saponification Value (1)
- satellite (1)
- saturation transfer difference NMR (1)
- scaffold-free (1)
- scalability (1)
- scalable functional genomic screening (1)
- school (1)
- science–policy interface (1)
- scurvy (1)
- second line antibiotics (1)
- secondary infarct growth (1)
- secondary prevention (1)
- secondary structure (1)
- seed yield (1)
- selenium (1)
- self-assembly (1)
- self-serving dishonesty (1)
- self-sovereign identities (1)
- selfcompassion (1)
- self‐organisation (1)
- selpercatinib (1)
- senescence (1)
- sensory ganglia (1)
- sensory neuron (1)
- sentinel (1)
- sentinel-2 (1)
- sequencing (1)
- serum (1)
- sex differences (1)
- shedding (1)
- sigma-1 receptor-directed molecular imaging (1)
- signaling (1)
- signalling pathways (1)
- simulation (1)
- single cell analysis (1)
- single-cell RNA-seq (1)
- site mapping (1)
- situation awareness (1)
- situational awareness (1)
- skeletal muscle (1)
- sky kinases (1)
- slice culture (1)
- small RNA (1)
- small fiber neuropathy (1)
- small-cell lung (1)
- smart journaling (1)
- smart speaker (1)
- smoking (1)
- social comparisons (1)
- social context (1)
- social inclusion (1)
- social interaction (1)
- social media (1)
- social movements (1)
- social psychology (1)
- social relationship (1)
- social role (1)
- social self‐organization (1)
- sodium-glucose co-transporter-2 inhibitors (1)
- solid‐state emission (1)
- somatic symptom burden (1)
- spatial error assessment (1)
- spatio-thematic coverage (1)
- spatiotemporal slump development (1)
- species range shifts (1)
- spectral CT (1)
- spectral shaping (1)
- speech motor impairment (1)
- speech recognition (1)
- spider (1)
- spin physics (1)
- spinning (1)
- sports medicine (1)
- sports therapy (1)
- ssVEP (1)
- standard schnauzer (1)
- star products (1)
- state (1)
- state–society relations (1)
- statistical data (1)
- statistics and numerical data (1)
- stem weevil (1)
- stereochemistry (1)
- stress factors (1)
- stress reduction (1)
- stress response (1)
- structure (1)
- structured light illumination (1)
- structure–activity relationships (1)
- students with disabilities (1)
- subcutaneous animal model (1)
- subjective perception of wealth (1)
- subjective wealth cues (1)
- sublethal effect (1)
- sublethal effects (1)
- substance use disorders (1)
- subtropical Indian Ocean dipole (1)
- succession (1)
- sugar responsiveness (1)
- sugars (1)
- suppressive capacity (1)
- suppressor (1)
- surface model (1)
- surface scanner (1)
- surgical treatment (1)
- surrogate model (1)
- sustainable development (1)
- sympathetic nervous system (1)
- symptom burden (1)
- synaptic transmission (1)
- synaptic vesicles (1)
- synergistic effect (1)
- synthesis (1)
- synthetic aperture RADAR (1)
- synthetic biology (1)
- systematic review (1)
- systems biology (1)
- table extraction (1)
- table understanding (1)
- tapeworm (1)
- taxanes (1)
- teacher education (1)
- telehealth (1)
- telemedicine (1)
- telescopes (1)
- temperature (1)
- temporal binding (1)
- temporal processing (1)
- temporary employment (1)
- tendon tissue engineering (1)
- tenogenic differentiation (1)
- test instrument (1)
- tetany (1)
- text line detection (1)
- theory (1)
- theory of science (1)
- therapy (1)
- threat (1)
- thrombosis (1)
- thyroid carcinoma (TC) (1)
- time frequency analyses (1)
- time series (1)
- tin (1)
- tin prefiltration (1)
- tissue preparation (1)
- tools overview (1)
- tooth extraction (1)
- total recall (1)
- toxicity (1)
- trabecular meshwork (1)
- trace elements (1)
- traditional almond orchard (1)
- traditional land use (1)
- trafficking (1)
- training (1)
- transcription (1)
- transcriptional regulation (1)
- translocation experiment (1)
- trastuzumab (1)
- trastuzumab deruxtecan (1)
- traumatic brain injury (1)
- tremor (1)
- triarylborane (1)
- triple-negative breast cancer (1)
- triplet excitons (1)
- truth (1)
- tuber (1)
- tuberculosis (1)
- tumor (1)
- tumor microenvironment (TME) (1)
- tumormicroenvironment (1)
- tumors (1)
- tumour (1)
- tumour immunology (1)
- ubiquitin proteasome system (1)
- ultra-low-dose CT (1)
- ultrafiltration (1)
- ultrahigh-field MRI (1)
- uncooperative space rendezvous (1)
- underwater 3D scanning (1)
- unicompartmental knee arthroplasty (1)
- upper limb (1)
- upslope shift (1)
- urban (1)
- urinary calculi (1)
- urinary tract infections (1)
- usability (1)
- user identification (1)
- user-centered design (1)
- user-centred design (1)
- vDEUQUA2021 (1)
- vacuolar calcium sensor (1)
- vacuum processable (1)
- valence framing (1)
- vasculature (1)
- venous infiltration (1)
- verbal n-back (1)
- vertebral pedicles (1)
- very long baseline interferometry (1)
- video games (1)
- video object detection (1)
- videooculography (1)
- vineyard terrace (1)
- virology (1)
- virtual non-contrast (1)
- visual memory (1)
- visual processes (1)
- vitamins (1)
- voltage gating (1)
- voluntary movement (1)
- walkability (1)
- warhead (1)
- weak statehood (1)
- wealth estimation (1)
- weight-bearing (1)
- white blood cells (1)
- white matter disease (1)
- women (1)
- workshop (1)
- wrong labelling (1)
- yam (1)
- zinc (1)
- zonulin (1)
- zoology (1)
Institute
- Theodor-Boveri-Institut für Biowissenschaften (52)
- Medizinische Klinik und Poliklinik I (21)
- Institut für Geographie und Geologie (20)
- Medizinische Klinik und Poliklinik II (20)
- Institut für Psychologie (19)
- Institut für Informatik (18)
- Neurologische Klinik und Poliklinik (18)
- Deutsches Zentrum für Herzinsuffizienz (DZHI) (13)
- Klinik und Poliklinik für Anästhesiologie (ab 2004) (13)
- Institut für Klinische Epidemiologie und Biometrie (11)
Schriftenreihe
Sonstige beteiligte Institutionen
- Klinische Studienzentrale (Universitätsklinikum) (2)
- Deutsches Zentrum für Präventionsforschung Psychische Gesundheit (DZPP) (1)
- Institut für Molekulare Infektionsbiologie (MIB) der Universität Würzburg (1)
- Interdisziplinäres Zentrum für Klinische Forschung (IZKF) (1)
- Würzburg-Dresden Cluster of Excellence ct.qmat (1)
Alpine bumble bees are the most important pollinators in temperate mountain ecosystems. Although they are used to encounter small-scale successions of very different climates in the mountains, many species respond sensitively to climatic changes, reflected in spatial range shifts and declining populations worldwide. Cuticular hydrocarbons (CHCs) mediate climate adaptation in some insects. However, whether they predict the elevational niche of bumble bees or their responses to climatic changes remains poorly understood. Here, we used three different approaches to study the role of bumble bees’ CHCs in the context of climate adaptation: using a 1,300 m elevational gradient, we first investigated whether the overall composition of CHCs, and two potentially climate-associated chemical traits (proportion of saturated components, mean chain length) on the cuticle of six bumble bee species were linked to the species’ elevational niches. We then analyzed intraspecific variation in CHCs of Bombus pascuorum along the elevational gradient and tested whether these traits respond to temperature. Finally, we used a field translocation experiment to test whether CHCs of Bombus lucorum workers change, when translocated from the foothill of a cool and wet mountain region to (a) higher elevations, and (b) a warm and dry region. Overall, the six species showed distinctive, species-specific CHC profiles. We found inter- and intraspecific variation in the composition of CHCs and in chemical traits along the elevational gradient, but no link to the elevational distribution of species and individuals. According to our expectations, bumble bees translocated to a warm and dry region tended to express longer CHC chains than bumble bees translocated to cool and wet foothills, which could reflect an acclimatization to regional climate. However, chain lengths did not further decrease systematically along the elevational gradient, suggesting that other factors than temperature also shape chain lengths in CHC profiles. We conclude that in alpine bumble bees, CHC profiles and traits respond at best secondarily to the climate conditions tested in this study. While the functional role of species-specific CHC profiles in bumble bees remains elusive, limited plasticity in this trait could restrict species’ ability to adapt to climatic changes.
Introduction: Grasslands cover one third of the agricultural area in Germany and are mainly used for fodder production. However, grasslands fulfill many other ecosystem functions, like carbon storage, water filtration and the provision of habitats. In Germany, grasslands are mown and/or grazed multiple times during the year. The type and timing of management activities and the use intensity vary strongly, however co-determine grassland functions. Large-scale spatial information on grassland activities and use intensity in Germany is limited and not openly provided. In addition, the cause for patterns of varying mowing intensity are usually not known on a spatial scale as data on the incentives of farmers behind grassland management decisions is not available.
Methods: We applied an algorithm based on a thresholding approach utilizing Sentinel-2 time series to detect grassland mowing events to investigate mowing dynamics in Germany in 2018–2021. The detected mowing events were validated with an independent dataset based on the examination of public webcam images. We analyzed spatial and temporal patterns of the mowing dynamics and relationships to climatic, topographic, soil or socio-political conditions.
Results: We found that most intensively used grasslands can be found in southern/south-eastern Germany, followed by areas in northern Germany. This pattern stays the same among the investigated years, but we found variations on smaller scales. The mowing event detection shows higher accuracies in 2019 and 2020 (F1 = 0.64 and 0.63) compared to 2018 and 2021 (F1 = 0.52 and 0.50). We found a significant but weak (R2 of 0–0.13) relationship for a spatial correlation of mowing frequency and climate as well as topographic variables for the grassland areas in Germany. Further results indicate a clear value range of topographic and climatic conditions, characteristic for intensive grassland use. Extensive grassland use takes place everywhere in Germany and on the entire spectrum of topographic and climatic conditions in Germany. Natura 2000 grasslands are used less intensive but this pattern is not consistent among all sites.
Discussion: Our findings on mowing dynamics and relationships to abiotic and socio-political conditions in Germany reveal important aspects of grassland management, including incentives of farmers.
Xiphophorus fish exhibit a clear phenotypic polymorphism in puberty onset and reproductive strategies of males. In X. nigrensis and X. multilineatus, puberty onset is genetically determined and linked to a melanocortin 4 receptor (Mc4r) polymorphism of wild-type and mutant alleles on the sex chromosomes. We hypothesized that Mc4r mutant alleles act on wild-type alleles by a dominant negative effect through receptor dimerization, leading to differential intracellular signaling and effector gene activation. Depending on signaling strength, the onset of puberty either occurs early or is delayed. Here, we show by Förster Resonance Energy Transfer (FRET) that wild-type Xiphophorus Mc4r monomers can form homodimers, but also heterodimers with mutant receptors resulting in compromised signaling which explains the reduced Mc4r signaling in large males. Thus, hetero- vs. homo- dimerization seems to be the key molecular mechanism for the polymorphism in puberty onset and body size in male fish.
Background
Adrenal incidentalomas with cortisol autonomy are associated with increased cardiovascular morbidity and mortality. Specific data on the clinical and biochemical course of affected patients are lacking.
Methods
Retrospective study from a tertiary referral centre in Germany. After exclusion of overt hormone excess, malignancy and glucocorticoid medication, patients with adrenal incidentalomas were stratified according to serum cortisol after 1 mg dexamethasone: autonomous cortisol secretion (ACS), >5.0; possible ACS (PACS), 1.9-5.0; non-functioning adenomas (NFA), ≤1.8 µg/dl.
Results
A total of 260 patients were enrolled (147 women (56.5%), median follow-up 8.8 (2.0-20.8) years). At initial diagnosis, median age was 59.5 (20-82) years, and median tumour size was 27 (10-116) mm. Bilateral tumours were more prevalent in ACS (30.0%) and PACS (21.9%) than in NFA (8.1%). Over time, 40/124 (32.3%) patients had a shift of their hormonal secretion pattern (NFA to PACS/ACS, n=15/53; PACS to ACS, n=6/47; ACS to PACS, n=11/24; PACS to NFA, n=8/47). However, none of the patients developed overt Cushing’s syndrome. Sixty-one patients underwent adrenalectomy (NFA, 17.9%; PACS, 24.0%; ACS, 39.0%). When non-operated patients with NFA were compared to PACS and ACS at last follow-up, arterial hypertension (65.3% vs. 81.9% and 92.0%; p<0.05), diabetes (23.8% vs. 35.6% and 40.0%; p<0.01), and thromboembolic events (PACS: HR 3.43, 95%-CI 0.89-13.29; ACS: HR 5.96, 95%-CI 1.33-26.63; p<0.05) were significantly less frequent, along with a trend towards a higher rate of cardiovascular events in case of cortisol autonomy (PACS: HR 2.23, 95%-CI 0.94-5.32; ACS: HR 2.60, 95%-CI 0.87-7.79; p=0.1). Twenty-five (12.6%) of the non-operated patients died, with higher overall mortality in PACS (HR 2.6, 95%-CI 1.0-4.7; p=0.083) and ACS (HR 4.7, 95%-CI 1.6-13.3; p<0.005) compared to NFA. In operated patients, prevalence of arterial hypertension decreased significantly (77.0% at diagnosis to 61.7% at last follow-up; p<0.05). The prevalence of cardiovascular events and mortality did not differ significantly between operated and non-operated patients, whereas thromboembolic events were significantly less frequent in the surgical treatment group.
Conclusion
Our study confirms relevant cardiovascular morbidity in patients with adrenal incidentalomas (especially those with cortisol autonomy). These patients should therefore be monitored carefully, including adequate treatment of typical cardiovascular risk factors. Adrenalectomy was associated with a significantly decreased prevalence of hypertension. However, more than 30% of patients required reclassification according to repeated dexamethasone suppression tests. Thus, cortisol autonomy should ideally be confirmed before making any relevant treatment decision (e.g. adrenalectomy).
Providing adaptive, independence-preserving and theory-guided support to students in dealing with real-world problems in mathematics lessons is a major challenge for teachers in their professional practice. This paper examines this challenge in the context of simulations and mathematical modelling with digital tools: in addition to mathematical difficulties when autonomously working out individual solutions, students may also experience challenges when using digital tools. These challenges need to be closely examined and diagnosed, and might – if necessary – have to be overcome by intervention in such a way that the students can subsequently continue working independently. Thus, if a difficulty arises in the working process, two knowledge dimensions are necessary in order to provide adapted support to students. For teaching simulations and mathematical modelling with digital tools, more specifically, these knowledge dimensions are: pedagogical content knowledge about simulation and modelling processes supported by digital tools (this includes knowledge about phases and difficulties in the working process) and pedagogical content knowledge about interventions during the mentioned processes (focussing on characteristics of suitable interventions as well as their implementation and effects on the students’ working process). The two knowledge dimensions represent cognitive dispositions as the basis for the conceptualisation and operationalisation of a so-called adaptive intervention competence for teaching simulations and mathematical modelling with digital tools. In our article, we present a domain-specific process model and distinguish different types of teacher interventions. Then we describe the design and content of a university course at two German universities aiming to promote this domain-specific professional adaptive intervention competence, among others. In a study using a quasi-experimental pre-post design (N = 146), we confirm that the structure of cognitive dispositions of adaptive intervention competence for teaching simulations and mathematical modelling with digital tools can be described empirically by a two-dimensional model. In addition, the effectiveness of the course is examined and confirmed quantitatively. Finally, the results are discussed, especially against the background of the sample and the research design, and conclusions are derived for possibilities of promoting professional adaptive intervention competence in university courses.
Following the implementation of 2018’s laws on the rights of persons with disabilities (PWDs) in Egypt, students with disabilities (SWDs) have both legal and moral rights to meaningful learning opportunities and inclusive education. Despite that, SWDs still have very limited education resources which limit their career aspirations and quality of life. In this respect, education whether as part of formal education or lifelong learning is central to the museum’s mission. Museums, as part of non-formal education, are being acknowledged for their educative powers and investments in the development of quality formal, non-formal, and informal learning experiences. Further, phrases such as “inclusivity,” “accessibility,” and “diversity” were notably included in the newly approved museum definition by ICOM (2022) emphasizing museums’ obligations to embrace societal issues and shape a cultural attitude concerning disability rights, diversity, and equality together with overcoming exclusionary educational practices. The study seeks to investigate the existing resources and inclusive practices in Egyptian museums to achieve non-formal education for SWDs. Qualitative research approaches have been employed to answer a specific question: How can Egyptian museums work within their governing systems to support the learning of SWDs beyond their formal education system? The study aims to assess the potential of Egyptian museums in facilitating learning for SWDs. Further, it examines the capability of Egyptian museums in contributing to informal and non-formal learning for SWDs and striving for inclusive education inspired by the social model of disability that fosters inclusive educational programs and adopts a human rights-based approach. The results revealed that Egyptian museums contributed to the learning of SWDs, yet small-scale programs and individual efforts, but they are already engaged in active inclusive practices that address the learning of SWDs. The study suggests that they need to be acknowledged and supported by the government as state instruments and direct actors in advancing inclusive education and implementing appropriate pedagogies in favor of SWDs.
Ultra-high field cardiac MRI in large animals and humans for translational cardiovascular research
(2023)
A key step in translational cardiovascular research is the use of large animal models to better understand normal and abnormal physiology, to test drugs or interventions, or to perform studies which would be considered unethical in human subjects. Ultrahigh field magnetic resonance imaging (UHF-MRI) at 7 T field strength is becoming increasingly available for imaging of the heart and, when compared to clinically established field strengths, promises better image quality and image information content, more precise functional analysis, potentially new image contrasts, and as all in-vivo imaging techniques, a reduction of the number of animals per study because of the possibility to scan every animal repeatedly. We present here a solution to the dual use problem of whole-body UHF-MRI systems, which are typically installed in clinical environments, to both UHF-MRI in large animals and humans. Moreover, we provide evidence that in such a research infrastructure UHF-MRI, and ideally combined with a standard small-bore UHF-MRI system, can contribute to a variety of spatial scales in translational cardiovascular research: from cardiac organoids, Zebra fish and rodent hearts to large animal models such as pigs and humans. We present pilot data from serial CINE, late gadolinium enhancement, and susceptibility weighted UHF-MRI in a myocardial infarction model over eight weeks. In 14 pigs which were delivered from a breeding facility in a national SARS-CoV-2 hotspot, we found no infection in the incoming pigs. Human scanning using CINE and phase contrast flow measurements provided good image quality of the left and right ventricle. Agreement of functional analysis between CINE and phase contrast MRI was excellent. MRI in arrested hearts or excised vascular tissue for MRI-based histologic imaging, structural imaging of myofiber and vascular smooth muscle cell architecture using high-resolution diffusion tensor imaging, and UHF-MRI for monitoring free radicals as a surrogate for MRI of reactive oxygen species in studies of oxidative stress are demonstrated. We conclude that UHF-MRI has the potential to become an important precision imaging modality in translational cardiovascular research.
Over the past years, scholars have explored eudaimonic video game experiences—profound entertainment responses that include meaningfulness, reflection, and others. In a comparatively short time, a plethora of explanations for the formation of such eudaimonic gaming experiences has been developed across multiple disciplines, making it difficult to keep track of the state of theory development. Hence, we present a theoretical overview of these explanations. We first provide a working definition of eudaimonic gaming experiences (i.e., experiences that reflect human virtues and encourage players to develop their potential as human beings fully) and outline four layers of video games—agency, narrative, sociality, and aesthetics—that form the basis for theorizing. Subsequently, we provide an overview of the theoretical approaches, categorizing them based on which of the four game layers their explanation mainly rests upon. Finally, we suggest the contingency of the different theoretical approaches for explaining eudaimonic experiences by describing how their usefulness varies as a function of interactivity. As different types of games offer players various levels of interactivity, our overview suggests which theories and which game layers should be considered when examining eudaimonic experiences for specific game types.
Fungal infections are a major global health burden where Candida albicans is among the most common fungal pathogen in humans and is a common cause of invasive candidiasis. Fungal phenotypes, such as those related to morphology, proliferation and virulence are mainly driven by gene expression, which is primarily regulated by kinase signaling cascades. Serine-arginine (SR) protein kinases are highly conserved among eukaryotes and are involved in major transcriptional processes in human and S. cerevisiae. Candida albicans harbors two SR protein kinases, while Sky2 is important for metabolic adaptation, Sky1 has similar functions as in S. cerevisiae. To investigate the role of these SR kinases for the regulation of transcriptional responses in C. albicans, we performed RNA sequencing of sky1Δ and sky2Δ and integrated a comprehensive phosphoproteome dataset of these mutants. Using a Systems Biology approach, we study transcriptional regulation in the context of kinase signaling networks. Transcriptomic enrichment analysis indicates that pathways involved in the regulation of gene expression are downregulated and mitochondrial processes are upregulated in sky1Δ. In sky2Δ, primarily metabolic processes are affected, especially for arginine, and we observed that arginine-induced hyphae formation is impaired in sky2Δ. In addition, our analysis identifies several transcription factors as potential drivers of the transcriptional response. Among these, a core set is shared between both kinase knockouts, but it appears to regulate different subsets of target genes. To elucidate these diverse regulatory patterns, we created network modules by integrating the data of site-specific protein phosphorylation and gene expression with kinase-substrate predictions and protein-protein interactions. These integrated signaling modules reveal shared parts but also highlight specific patterns characteristic for each kinase. Interestingly, the modules contain many proteins involved in fungal morphogenesis and stress response. Accordingly, experimental phenotyping shows a higher resistance to Hygromycin B for sky1Δ. Thus, our study demonstrates that a combination of computational approaches with integration of experimental data can offer a new systems biological perspective on the complex network of signaling and transcription. With that, the investigation of the interface between signaling and transcriptional regulation in C. albicans provides a deeper insight into how cellular mechanisms can shape the phenotype.
The signals that coordinate and control movement in vertebrates are transmitted from motoneurons (MNs) to their target muscle cells at neuromuscular junctions (NMJs). Human NMJs display unique structural and physiological features, which make them vulnerable to pathological processes. NMJs are an early target in the pathology of motoneuron diseases (MND). Synaptic dysfunction and synapse elimination precede MN loss suggesting that the NMJ is the starting point of the pathophysiological cascade leading to MN death. Therefore, the study of human MNs in health and disease requires cell culture systems that enable the connection to their target muscle cells for NMJ formation. Here, we present a human neuromuscular co-culture system consisting of induced pluripotent stem cell (iPSC)-derived MNs and 3D skeletal muscle tissue derived from myoblasts. We used self-microfabricated silicone dishes combined with Velcro hooks to support the formation of 3D muscle tissue in a defined extracellular matrix, which enhances NMJ function and maturity. Using a combination of immunohistochemistry, calcium imaging, and pharmacological stimulations, we characterized and confirmed the function of the 3D muscle tissue and the 3D neuromuscular co-cultures. Finally, we applied this system as an in vitro model to study the pathophysiology of Amyotrophic Lateral Sclerosis (ALS) and found a decrease in neuromuscular coupling and muscle contraction in co-cultures with MNs harboring ALS-linked SOD1 mutation. In summary, the human 3D neuromuscular cell culture system presented here recapitulates aspects of human physiology in a controlled in vitro setting and is suitable for modeling of MND.