Refine
Has Fulltext
- yes (547)
Is part of the Bibliography
- yes (547)
Year of publication
- 2018 (547) (remove)
Document Type
- Journal article (358)
- Doctoral Thesis (156)
- Preprint (22)
- Conference Proceeding (3)
- Other (2)
- Working Paper (2)
- Book (1)
- Book article / Book chapter (1)
- Habilitation (1)
- Master Thesis (1)
Language
- English (547) (remove)
Keywords
- Parton Distributions (23)
- Hadron-Hadron scattering (experiments) (16)
- Positronen-Emissions-Tomografie (16)
- Extension (14)
- PET (14)
- Decay (13)
- boron (12)
- Squark (11)
- ++ (10)
- positron emission tomography (9)
- Mass (7)
- Maus (7)
- Physics (7)
- Cross-Section (6)
- Gluino Production (6)
- LHC (6)
- Parton distributions (6)
- diborenes (6)
- Higgs bosons (5)
- MASS (5)
- Model (5)
- SPECT (5)
- carbenes (5)
- inflammation (5)
- neuroendocrine tumor (5)
- ADHD (4)
- Beyond Standard Model (4)
- Breaking (4)
- Distributions (4)
- Energy (4)
- Fluoreszenzmikroskopie (4)
- Hadron colliders (4)
- Hierarchy (4)
- Models (4)
- PRRT (4)
- Stress (4)
- Supersymmetry (4)
- Thrombozyt (4)
- Top quark (4)
- Topologischer Isolator (4)
- physical activity (4)
- 18F-DCFPyL (3)
- 18F-FDG (3)
- Aspergillus fumigatus (3)
- Biene (3)
- Biofilm (3)
- Boson (3)
- DaTscan (3)
- Events (3)
- Fluorescence (3)
- Fluoreszenz (3)
- G-Protein gekoppelte Rezeptoren (3)
- Hadron Colliders (3)
- Kernspintomografie (3)
- MRI (3)
- Makroökonomie (3)
- Measuring Masses (3)
- Microscopy (3)
- Monte-Carlo (3)
- PET/CT (3)
- Particle data analysis (3)
- Polymere (3)
- RADS (3)
- SSTR (3)
- Search (3)
- Stammzelle (3)
- Staphylococcus aureus (3)
- Supersymmetric models (3)
- T cells (3)
- Thrombose (3)
- Trypanosomen (3)
- Weak (3)
- ageing (3)
- apoptosis (3)
- breast cancer (3)
- cancer (3)
- children (3)
- diborynes (3)
- immune evasion (3)
- induced pluripotent stem cells (3)
- infection (3)
- machine learning (3)
- mitochondria (3)
- mouse model (3)
- obesity (3)
- pathogens (3)
- prostate cancer (3)
- psychology (3)
- spectroscopy (3)
- stroke (3)
- theranostics (3)
- 11C-HED (2)
- 123I-mIBG (2)
- 123I-metaiodobenzylguanidine (2)
- 18F-LMI1195 (2)
- ABCG2 (2)
- Activation (2)
- Alzheimer’s disease (2)
- Ants (2)
- Apis mellifera (2)
- Arteriosklerose (2)
- Arzneimittelforschung (2)
- B cells (2)
- Biomarkers (2)
- Boron (2)
- Bosons (2)
- Cadherine (2)
- Camponotus floridanus (2)
- Cancer immunotherapy (2)
- Catalysis (2)
- China (2)
- Code examples (2)
- Coffin-Lowry syndrome (2)
- DFT calculations (2)
- DNA (2)
- Diabetes mellitus (2)
- Drosophila (2)
- Drosophila melanogaster (2)
- Ecology (2)
- Emotion (2)
- Entwicklung (2)
- Epigenetik (2)
- Europäische Union (2)
- Extrazelluläre Matrix (2)
- Femtosekundenspektroskopie (2)
- Fernerkundung (2)
- GPCR (2)
- Genom (2)
- Gluino production (2)
- Hämostase (2)
- Innate immunity (2)
- Ioflupane (2)
- Jets (2)
- Leistungsbewertung (2)
- Mikroskopie (2)
- Muscarinrezeptor (2)
- Myc (2)
- Neisseria meningitidis (2)
- Netzwerk (2)
- Optische Spektroskopie (2)
- PSMA-PET (2)
- Pair production (2)
- Parkinson (2)
- Parkinson Disease (2)
- Parkinson-Krankheit (2)
- Patron Distributions (2)
- Performance Evaluation (2)
- Phänologie (2)
- Plasma (2)
- Plus plus (2)
- Positron Emission Tomography (2)
- Program (2)
- Prostate Cancer (2)
- Proton-Proton Collisions (2)
- QAHE (2)
- QCD (2)
- Quanten-Hall-Effekt (2)
- Quecksilbertellurid (2)
- RSK2 (2)
- Rhodium (2)
- Risk factors (2)
- SPECT/CT (2)
- SQH method (2)
- Signaltransduktion (2)
- Simulation (2)
- Sozialpsychologie (2)
- Squaraine (2)
- Supramolekulare Chemie (2)
- Survival (2)
- Symmetry (2)
- Symmetry-breaking (2)
- Tagesrhythmus (2)
- Taufliege (2)
- Textverstehen (2)
- Timing (2)
- Transcriptome (2)
- Trypanosoma brucei (2)
- Ultrakurzzeitspektroskopie (2)
- Umverteilung (2)
- Ungleichheit (2)
- Virchow Node (2)
- Virulenzfaktor (2)
- WZ (2)
- X-ray crystallography (2)
- [177Lu]-DOTATATE/-DOTATOC (2)
- [68Ga] (2)
- adolescents (2)
- anxiety (2)
- bees (2)
- bioinformatics (2)
- biological models (2)
- biomedical materials (2)
- bipolar disorder (2)
- borylene (2)
- calcium (2)
- carbon dioxide (2)
- cardiomyocytes (2)
- chemokines (2)
- chronic kidney disease (2)
- circadian clock (2)
- circadian rhythm (2)
- classification (2)
- data mining (2)
- depression (2)
- desirable difficulties (2)
- diet (2)
- diradicals (2)
- division of labor (2)
- emotion (2)
- epigenetics (2)
- evolution (2)
- fatty acid (2)
- ferroelectricity (2)
- fitness (2)
- fluorescence (2)
- foraging (2)
- forest health (2)
- gamma rays (2)
- genomics (2)
- glucose (2)
- glycine receptor (2)
- hemodialysis (2)
- hiPSC-CM (2)
- honeybee (2)
- immunology (2)
- insulin (2)
- interferon (2)
- knee arthroplasty (2)
- land use (2)
- load management (2)
- low-valent compounds (2)
- medullary thyroid carcinoma (2)
- melanoma (2)
- metabolomics (2)
- miRNS (2)
- molecular imaging (2)
- mothers (2)
- muscle degeneration (2)
- myocardial sympathetic innervation imaging (2)
- neuroblastoma (2)
- optical spectroscopy (2)
- optimization (2)
- optogenetics (2)
- pancreas (2)
- periprosthetic infection (2)
- personalized medicine (2)
- personalized treatment (2)
- platelets (2)
- polymer (2)
- pp Collisions (2)
- pp collisions (2)
- precision medicine (2)
- proteins (2)
- self (2)
- self-assembly (2)
- sensor fusion (2)
- somatostatin receptor (2)
- spontaneous symmetry breaking (2)
- startle disease (2)
- stem cell therapy (2)
- super-resolution microscopy (2)
- symbiosis (2)
- therapy (2)
- tissue engineering (2)
- tracer (2)
- tumor heterogeneity (2)
- two-stage exchange (2)
- tyrosine kinase inhibitor (2)
- vandetanib (2)
- virtual reality (2)
- *-algebra (1)
- 11C-Hydroxyephedrine (1)
- 11C-hydroxyephedrine (1)
- 123I-Ioflupane (1)
- 16S metabarcoding (1)
- 18F-FDS (1)
- 18F-flurpiridaz (1)
- 18FFBnTP (1)
- 2- deoxy-2-(18F)fluoro-D-glucose (1)
- 2-Aminoethylphosphonic acid (1)
- 2-deoxy-2-(18F)fluoro-D-glucose (1)
- 3D echocardiography (1)
- 3D modeling (1)
- 3D point cloud (1)
- 3D powder printing (1)
- 3D printing (1)
- 3D thermal mapping (1)
- 4TH-Corner Problem (1)
- 53BP1 (1)
- 68Ga-DOTATATE/-TOC (1)
- 8 TEV (1)
- 99mTc-DTPA (1)
- ACL (1)
- AChE inhibitor (1)
- ADHS (1)
- AI (1)
- AIME (1)
- AKI (1)
- AMP-activated protein kinase (AMPK) (1)
- APC (1)
- ARPES (1)
- ATLAS <Teilchendetektor> (1)
- ATLAS New Small Wheels (NSW) (1)
- ATLAS experiment (1)
- Accelerator modelling and simulations (multi-particle dynamics; single-particle dynamics) (1)
- Achillea Fragrantissima (1)
- Acid adaptation (1)
- Ackerschmalwand (1)
- Acoustic equations (1)
- Acoustics (1)
- Acute myeloid leukemia (1)
- Acyrthosiphon pisum (1)
- AdS-CFT Correspondence (1)
- Adhäsion (1)
- Adipositas (1)
- Adsorption (1)
- Affekt (1)
- African trypanosomes (1)
- Agonist (1)
- Ahmed (1)
- Alemtuzumab (1)
- Algorithm (1)
- Algorithmus (1)
- Aliphatics (1)
- Alkaloide (1)
- Alkamiden (1)
- Alkamides (1)
- Allogeneic stem cell transplantation (1)
- Allotransplantation (1)
- Ameise (1)
- Ameisen (1)
- American foulbrood (1)
- Analysis (1)
- Anderson-Lokalisation (1)
- Aneuploidy (1)
- Angeborene Immunität (1)
- Angst (1)
- Animal behavior IntelliCage system (1)
- Animal model (1)
- Ant (1)
- Antibiotic (1)
- Antibody clearance (1)
- Antidepressants (1)
- Antitrypanosomal (1)
- Antitrypanosomen (1)
- Anxiety (1)
- Aorta (1)
- Approximationsalgorithmus (1)
- Arbeitsgedächtnis (1)
- Arbeitsmarkt (1)
- ArsZ (1)
- Arterie (1)
- Artery (1)
- Articular-Cartilage (1)
- Arzneimittel (1)
- Arzneimitteldesign (1)
- Aspergillus (1)
- AstA (1)
- Asylpolitik (1)
- Asymptotic Preserving (1)
- Atherosclerosis (1)
- Atmosphäre (1)
- Atomic and molecular interactions with photons (1)
- Atomketten (1)
- Atta vollenweideri (1)
- Attitudes towards immigrants (1)
- Auditory pathway (1)
- Aurora-A (1)
- Auto-Scaling (1)
- Automation (1)
- Automatisiertes Fahren (1)
- Autonomes Fahrzeug (1)
- Axion (1)
- B-0 (1)
- B-Lymphozyt (1)
- BB bond activation (1)
- BB/BC Bond activation (1)
- BC bond activation (1)
- BCL6 (1)
- BRAF (1)
- BRCA1 (1)
- BRCA2 (1)
- BRIP1 gene (1)
- Bacillus subtilis (1)
- Bacteria (1)
- Bacterial infection (1)
- Baerveldt (1)
- Bakterien (1)
- Bakteriophagen (1)
- Banach-Raum (1)
- Bank Credit Market (1)
- Bankgeschäft (1)
- Bariumtitanat (1)
- Bayes analysis (1)
- Bayes-Verfahren (1)
- Bayesian methods (1)
- Bayesian model comparison (1)
- Beatty sequence (1)
- Beauveria bassiana (1)
- Beige adipocytes (1)
- Benchmarking (1)
- Benutzerinteraktion (1)
- Bewusstsein (1)
- Bi2Se3 (1)
- Bildgebendes Verfahren (1)
- Bildverarbeitung (1)
- Bioabbaubarkeit (1)
- Biochemical-Diagnosis (1)
- Biodegradability (1)
- Biodiversity (1)
- Biodiversity Exploratories (1)
- Biodiversitätsexploratorien (1)
- Biofilm formation (1)
- Biofilms (1)
- Bioinformatics (1)
- Bioinformatik (1)
- Biokinetics (1)
- Biologie (1)
- Biologischer Abbau (1)
- Biomarker (1)
- Biomechanical Properties (1)
- Biomedical engineering (1)
- Bioverfügbarkeit (1)
- Bipolar Disorder (1)
- Bismutselenide (1)
- Bodipy (1)
- Body size (1)
- Body weight (1)
- Bone (1)
- Bootstrap (1)
- Bor (1)
- Borylierung (1)
- Bottom-up (1)
- Breeding system (1)
- Bregman distance (1)
- Brushite (1)
- Bruton Tyrosine Kinase (1)
- Burgers-Gleichung (1)
- Burkina Faso (1)
- Butyrylcholinesterase (1)
- Bärtierchen (1)
- C-C coupling (1)
- C/EBP (1)
- C5aR1 (1)
- CAGSSS (1)
- CCHamide1 (1)
- CCL4 (1)
- CD28 costimulation (1)
- CD28 superagonists (1)
- CD3/19 depletion (1)
- CD34 selection (1)
- CD4\(^{+}\) T helper cells (1)
- CD52 (1)
- CD74 (1)
- CDH13 (1)
- CDR3 sequences (1)
- CIR aerial imagery (1)
- CLEC-2 (1)
- CML (1)
- CNG channel (1)
- CNS (1)
- CO2 fixation (1)
- COMT (1)
- COPD (1)
- CPAF activation (1)
- CRAC (1)
- CRHR1 (1)
- CRISPR/Cas9 (1)
- CXCL13 (1)
- Ca2+ (1)
- Cadherin 13 (1)
- Cadherin-13 (1)
- Caenorhabditis elegans (1)
- Calcium (1)
- Calcium Citrate (1)
- Calcium phosphate (1)
- Calciumphosphate (1)
- Calibration (1)
- Camponotus (1)
- Cancer (1)
- Cancer models (1)
- Cancer therapeutic resistance (1)
- Candida albicans (1)
- Cannabinoid Receptor (1)
- CarO (1)
- Carbenes (1)
- Cardiovascular biology (1)
- Cardiovascular diseases (1)
- Cartilage Regeneration (1)
- Catheter Lock Solution (1)
- Catheter-related Bloodstream Infections (CRBSI) (1)
- Cauchy-Born rule (1)
- Caudate nucleus (1)
- Cell differentiation (1)
- Cellular imaging (1)
- Central Spin (1)
- Ceramides (1)
- Cerebellar nuclei (1)
- Chain-length distribution (1)
- Chains (1)
- Charged-Particles (1)
- Charm quark (1)
- Charmonia (1)
- Chemische Reaktion (1)
- Chemische Synthese (1)
- Chemistry (1)
- Chemotherapeutic resistance (1)
- Cherenkov detectors (1)
- Chimeric antigen receptor (1)
- Chinolonderivate (1)
- Chlamydia (1)
- Chlamydienkrankheit (1)
- Cholinesterase (1)
- Chromatin (1)
- Chromatin and Epigenetics (1)
- Chromophor (1)
- Chronic heart-failure (1)
- Chronic myeloid leukaemia (1)
- Chronobiologie (1)
- Circadian Clock (1)
- Circadiane Uhr (1)
- Circadianer Rhythmus (1)
- Circular dichroism (1)
- Climate change (1)
- Clinical trial (1)
- Clonality (1)
- Cloud Computing (1)
- Coffin–Lowry syndrome (1)
- Coherent Multidimensional Spectroscopy (1)
- Coherent control (1)
- Cohesin complex (1)
- Collagen (1)
- Collicions (1)
- Colloidal Stability (1)
- Color (1)
- Combination (1)
- Community ecology (1)
- Comparative genomics (1)
- Complexity (1)
- Component selectivity (1)
- Compressive Properties (1)
- Computational drug design (1)
- Computersimulation (1)
- Concealed Information Test (1)
- Confidence interval (1)
- Conformal Field Theory (1)
- Conical Intersection (1)
- Consistent partial least squares (1)
- Copal\(^®\) spacem (1)
- Copeptin (1)
- Copper (1)
- Copper catalysis (1)
- Copy number changes (1)
- Corneal confocal microscopy (1)
- Corticoliberin (1)
- Corynebacterium urealyticum (1)
- Counterfeit Medicines (1)
- Coupled Electron-Nuclear Dynamics (1)
- Cross-section (1)
- Cuticle (1)
- Cuticular water permeabilities (1)
- Cuticular waxes (1)
- Cyclics (1)
- Cyclotrimerisation (1)
- Cyropaidia (1)
- D665 (1)
- DCGAN (1)
- DECAY (1)
- DFNB68 (1)
- DFT-LDA (1)
- DHAP (1)
- DLBCL (1)
- DM2 (1)
- DNA Breaks (1)
- DNA catalyst (1)
- DNA complex (1)
- DNA damage (1)
- DNA methylation (1)
- DNA transcription (1)
- DNMR-Spektroskopie (1)
- DRG (1)
- DT40 cells (1)
- Dark-Matter (1)
- Dark-matter production (1)
- Data Science (1)
- DecaWave (1)
- Decay sequence (1)
- Decays (1)
- Decoherence (1)
- Deep Georeferencing (1)
- Deformation (1)
- Deformationsquantisierung (1)
- Delta Repertoire (1)
- Democracy Matrix (1)
- Dendritic cells (1)
- Dendritische Zelle (1)
- Dependence (1)
- Depression (1)
- Design (1)
- Desynchronisation (1)
- Desynchronization (1)
- Diabetic nephropathies (1)
- Diagnose (1)
- Diagnosis (1)
- Dicarboximide (1)
- Dicarboximides (1)
- Dietary process-related contaminants (1)
- Differential Cross-Sections (1)
- Differentialgleichung (1)
- Dilatometrie (1)
- Diophantine approximation (1)
- Dipeptidyl-peptidase IV inhibitors (1)
- Discrete-to-continuum limits (1)
- Disney (1)
- Disorder (1)
- Dmrt1bY (1)
- Doppelquantenkohärenz (1)
- Drahtloses Sensornetz (1)
- Drosophila Myc transcription growth PAF1 (1)
- Drosophila melanogaster motoneuron (1)
- Drosophila model (1)
- Drug delivery (1)
- Dualstere Liganden (1)
- Dualsteric Ligands (1)
- Dyad (1)
- Dyade (1)
- Dynamic magnetic resonance imaging (1)
- Dynamical Supersymmetry Breaking (1)
- Dynamics (1)
- Dynamische MR Bildgebung (1)
- Dynamische Messung (1)
- E. coli Nissle 1917 (1)
- EAE (1)
- ECG (1)
- EDC-NHS chemistry (1)
- EEG (1)
- EHEC (1)
- EU Governance (1)
- EW (1)
- Eccentricities (1)
- Ecological Networks (1)
- Ecological networks (1)
- Economic Growth (1)
- Ecosystem ecology (1)
- Effizienter Algorithmus (1)
- Efflux pump (1)
- Egypt (1)
- Einkommensverteilung (1)
- Einstellung gegenüber Immigranten (1)
- Einwanderung (1)
- Elasticity (1)
- Elasticity tensor (1)
- Elastizitätstensor (1)
- Elderly (1)
- Electron Flux (1)
- Electroweak interaction (1)
- Elektroencephalogramm (1)
- Elektronenspektroskopie (1)
- Elektronentransfer (1)
- Elite Rowers (1)
- Elliptische Differentialgleichung (1)
- Empirical Economics (1)
- Empirische Wirtschaftsforschung (1)
- Employment (1)
- Endogenous clock (1)
- Endophytische Pilze (1)
- Energieaufnahme (1)
- Energies (1)
- Energy Transfer (1)
- Enoyl-acyl-carrier-protein-Reductase <Enoyl-[acyl-carrier-protein]-Reductase> (1)
- Enterohemorrhagic Escherichia coli (1)
- Entomology (1)
- Entropiebedingung (1)
- Entropielösung (1)
- Entropy admissibility condition (1)
- Entwicklung chimärer Antigenrezeptor T-Zellen (1)
- Entzündung (1)
- Entzündungsschmerz (1)
- Enzymes (1)
- Enzyminhibitor (1)
- Epichloe (1)
- Epichloë (1)
- Epistemic Competences (1)
- Epistemische Kompetenzen (1)
- Epitope (1)
- Erythrozyt (1)
- Erythrozytenadhärenz (1)
- Euclidean plane (1)
- Euklidische Ebene (1)
- Euler equations (1)
- European Asylum System (1)
- European Union (1)
- European foulbrood (1)
- Europäische Zentralbank (1)
- Event (1)
- Exacerbation (1)
- Exazerbation (1)
- Excited states (1)
- Exciton dynamics (1)
- Excitons (1)
- Executive Compensation (1)
- Existenz und Eindeutigkeit (1)
- Exotic mesons (1)
- Experiment / Sozialpsychologie (1)
- Expression (1)
- Extensions of Higgs sector (1)
- Extensions of gauge sector (1)
- External exposure assessment (1)
- Extracellular matrix proteins (1)
- Exziton (1)
- F-actin (1)
- FAIR (1)
- FGF (1)
- FGF-2 (1)
- FGF21 (1)
- FV45 (1)
- Fabry disease (1)
- Fabry-Krankheit (1)
- Factor messenger-RNA (1)
- Fagus sylvatica (1)
- Fahrerablenkung (1)
- Fahrerverhalten (1)
- Fanconi anaemia (1)
- Farbensehen (1)
- Feedforward loop (1)
- Feldeffekttransistor (1)
- Femtosekundenlaser (1)
- Ferroelektrikum (1)
- Fibroblast Growth Factor-21 (1)
- Fibroblastenwachstumsfaktor (1)
- Field effect transistor (1)
- Finanzkrise (1)
- Finite-Volumen-Methode (1)
- Fitness (1)
- Flavoniden (1)
- Flavonoinds (1)
- Fluconazole (1)
- Fluid-Partikel-Strömung (1)
- Fluorescence Microscopy (1)
- Fluorescence Resonance Energy Transfer (1)
- Fluorescence resonance energy transfer (1)
- Fluorescence spectroscopy (1)
- Flüchtlingskrise (1)
- Flüssigkristall (1)
- Foraging behaviour (1)
- Formulierungsentwicklung (1)
- Fortran code (1)
- Fourier-Spektroskopie (1)
- Fragmentation (1)
- Fremdscham (1)
- Fremdschämen (1)
- Frequency (1)
- Fruit (1)
- Fulleren-Netzwerk (1)
- Fullerene (1)
- Functional differential equations (1)
- Fungal cell-walls (1)
- Fusarium fujikuroi (1)
- Fälschung (1)
- Förderung (1)
- G Protein-Coupled Receptors (1)
- G protein-coupled receptors (1)
- G-Protein gekoppelte Rezeptor (1)
- GABAerge Nervenzelle (1)
- GAMMA (1)
- GAN (1)
- GI (1)
- GLP-1 (1)
- GPVI (1)
- GPX4 (1)
- Galactosidase <alpha-> (1)
- Galectin-1 (1)
- Gamma (1)
- Gamma-convergence (1)
- Gasgemisch (1)
- Gasionisationsdetektor (1)
- Gastrointestinal (1)
- Gauge-gravity correspondence (1)
- Gb3 accumulation (1)
- Gefühl (1)
- Gehirn (1)
- Gehirn-Computer-Schnittstelle (1)
- Geitonogamy (1)
- Geldpolitik (1)
- Gene Regulation (1)
- Gene-expression (1)
- Gene-prediction (1)
- Generalized Nash Equilibrium Problem (1)
- Genetics (1)
- Genexpression (1)
- Genome editing (1)
- Genomeditierung (1)
- Genregulation (1)
- Geo-spatial behavior (1)
- Geografie (1)
- Geometric Phase (1)
- Georeferenzierung (1)
- German healthcare system (1)
- Germanium telluride (1)
- Germination (1)
- Geruchssinn (1)
- Gland (1)
- Global Change (1)
- Globaler Wandel (1)
- Globalisierung (1)
- Glomerular filtration (1)
- Gluon (1)
- Gluon Fusion (1)
- Glutamin (1)
- Glycoprotein GPV (1)
- Glykoproteine (1)
- God in 3 Macc (1)
- Gold-Nanoparticles (1)
- Golgi-Apparat (1)
- Governance (1)
- Graph (1)
- Gräser (1)
- Guinier-Preston zones (1)
- HECT (1)
- HFmrEF (1)
- HIGGS (1)
- HIV (1)
- HLA class II (1)
- HLA peptidome (1)
- HP1432, Hpn2 (1)
- HPLC (1)
- HUWE1 (1)
- Hadron Collider (1)
- Halbleiter (1)
- Haploidentical (1)
- Hardware (1)
- Heavy-Particles (1)
- Hekate (1)
- Helicität <Chemie> (1)
- Helicobacter pylori (1)
- Helix- and Zick-Zack-Konformere (1)
- Helix- and Zig-Zag-Conformers (1)
- Hellenistic kingship (1)
- Hematopoietic Stem Cell (1)
- Hemostasis (1)
- Herzinfarkt (1)
- Herzkatheter (1)
- Herzkathetereingriff (1)
- Heubacillus (1)
- Hexaarylbenzene (1)
- HgTe (1)
- Hibernation (1)
- Hic-5 (1)
- Hierarchische Matrix (1)
- Hierarchy problem (1)
- Higgs (1)
- Higgs boson (1)
- Higgs boson decays (1)
- Higgs boson mass (1)
- Higgs physics (1)
- High-throughput screening (1)
- Higher Education (1)
- Hippocampus (1)
- Histatin 5 (1)
- Historical Maps (1)
- Historische Karte (1)
- Historische Landkarten (1)
- Hochauflösende Mikroskopie (1)
- Homöostase (1)
- Hospitalismus <Hygiene> (1)
- Host defense (1)
- Host-endosymbiont interactions (1)
- Host-pathogen interaction (1)
- Host-pathogen interactions (1)
- Housing Markets (1)
- Hsp90 (1)
- Human Knee (1)
- Human Medial Meniscus (1)
- Human Resource Management <Humanvermögen> <Personalentwicklung> (1)
- Human behavior (1)
- Human behaviour (1)
- Hurst Exponent (1)
- Hyaluronic acid (1)
- Hyaluronsäure (1)
- Hybrid (1)
- Hybrid GPCR Ligands (1)
- Hydrogel (1)
- Hymenoptera (1)
- Hyperbolic Partial Differential Equations (1)
- Hyperbolische Differentialgleichung (1)
- Hypothesis comparison (1)
- Hypothetical gauge bosons (1)
- Hypothetical particle physics models (1)
- IARS2 (1)
- ICD (1)
- IDO-1 (1)
- IFN-gamma (1)
- IGF-I (1)
- IL-23 (1)
- Ibrutinib (1)
- Identification (1)
- Image Processing (1)
- Imatinib (1)
- Immun-Transkriptom (1)
- Immune Thrombocytopenia (1)
- Immunosuppression (1)
- Immunreaktion (1)
- Immunsystem (1)
- Immuntherapie (1)
- Immunthrombozytopenie (1)
- Importwettbewerb (1)
- Impulsformung (1)
- Impurity Profiling (1)
- Inbreeding depression (1)
- Inequality (1)
- Influenza (1)
- Information Extraction (1)
- Informationsverarbeitung (1)
- Injuries (1)
- Innere Uhr (1)
- Innervation (1)
- Insect (1)
- Insekt (1)
- Instrumentelle Analytik (1)
- Insulin-like Growth Factor (1)
- Integrated circuit (1)
- Integriert-optisches Bauelement (1)
- Integrodifferentialgleichung (1)
- Interactome (1)
- Interaktion (1)
- Intergenerational income mobility (1)
- Intergenerative Einkommensmobilität (1)
- Interleukin 6 (1)
- Interleukine (1)
- Internet der Dinge (1)
- Intervention (1)
- Intestinal Intraepithelial Lymphocy (1)
- Intestinal stem cell (1)
- Intragenerational wage mobility (1)
- Intragenerative Lohnmobilität (1)
- Intrinsic charm (1)
- Invertebrate vision (1)
- IoT (1)
- Ion channel function (1)
- Ionenkanal (1)
- Iridium bis(phosphinite) pincer complexes (1)
- Iridiumkomplexe (1)
- Ischemic stroke (1)
- Isocrates (1)
- Itinerare (1)
- Itineraries (1)
- J- and H-Aggregate (1)
- J- and H-Aggregates (1)
- JNK (1)
- Jacobian matrix (1)
- Jmjd6 (1)
- Josephson junction (1)
- K* µ+μ− (1)
- KDIGO (1)
- Karte (1)
- Katalyse (1)
- Kation (1)
- Kirchhoff's law (1)
- Klima (1)
- Kloosterman sum (1)
- Klotho-related molecules (1)
- Knochenersatz (1)
- Knochenmark (1)
- Knochenzemente (1)
- Knockout (1)
- Knockout <Molekulargenetik> (1)
- Knorpel (1)
- Kohlendioxid (1)
- Kohlenstoff-Nanoröhre (1)
- Kohärente Kontrolle (1)
- Kohärente Multidimensionale Spektroskopie (1)
- Kommunikation (1)
- Kommunikationsprotokoll (1)
- Kompetenzen im Hochschulsektor (1)
- Komplexauge (1)
- Komplexität (1)
- Kontrollierte Wirkstofffreisetzung (1)
- Korrekt gestelltes Problem (1)
- Korrelative Mikroskopie (1)
- Krebs <Medizin> (1)
- Krebsimmuntherapie (1)
- Kritische Infrastruktur (1)
- Kultur (1)
- Kupfer katalyse (1)
- Kupplungsreaktion (1)
- LAD (1)
- LHS (1)
- Labor Mobility (1)
- Laguerre-Gauss (1)
- Lambdoide Prophagen (1)
- Landnutzung (1)
- Landsat (1)
- Landwirtschaft (1)
- Large detector systems for particle and astroparticle physics (1)
- Laser Pulse Shaping (1)
- Laser scanning (1)
- Laserimpulsformung (1)
- Lasermode (1)
- Latimeria menadoensis (1)
- Leaf (1)
- Leaf cutting ants (1)
- Leishmania (1)
- Lepton (1)
- Leptons (1)
- Lewis acids (1)
- Lgr5 (1)
- Lidar (1)
- Ligand (1)
- Ligand <Biochemie> (1)
- Light (1)
- Linagliptin (1)
- Linked Data (1)
- Lithography (1)
- Localization (1)
- Locked-in-Syndrom (1)
- Logik (1)
- Lolium perenne (1)
- Long-term follow-up (1)
- Lower Reference Value (1)
- Lu-177 (1)
- Lumineszenz (1)
- Lutetium (1)
- Lymphoma (1)
- Löslichkeit (1)
- MAC Protocol (1)
- MDD (1)
- MDR1 (1)
- ME/CFS (1)
- MIP-1β (1)
- MIPs (1)
- MPI (1)
- MRR1 (1)
- MRT (1)
- MS (1)
- MUD (1)
- MYC (1)
- Maccabees (1)
- Machine Learning (1)
- Machzahl (1)
- Macroscopic transport (1)
- Magnetfeldeffekt (1)
- Magnetic Resonance Spectroscopy Imaging (1)
- Magnetic Topological Insulator (1)
- Magnetic resonance (1)
- Magnetic resonance imaging (1)
- Magnetische Resonanz (1)
- Magnetresonanztomografie (1)
- Majorana bound state (1)
- Malaria (1)
- Malignancies (1)
- Malvaviscus arboreus (1)
- Manisch-depressive Krankheit (1)
- Marine sponge-derived actinomycetes (1)
- Marine sponges (1)
- Markarian 501 (1)
- Marrow (1)
- Maschinelles Lernen (1)
- Mass Spectrum (1)
- Masse (1)
- Materials chemistry (1)
- Mathematisches Modell (1)
- Measuring masses (1)
- Mechanisms (1)
- Mechanistic model (1)
- Medicago truncatula (1)
- Medullärer Schilddrüsenkrebs (1)
- Megakaryocyte (1)
- Megakaryocytes (1)
- Megakaryozyt (1)
- Mehrgitterverfahren (1)
- Meiose (1)
- Meiosis (1)
- Melanom (1)
- Melanoma (1)
- Melt electrospinning (1)
- Membranlipide (1)
- Men (1)
- Mensch (1)
- Mensch-Maschine-Interaktion (1)
- Mensch-Maschine-Kommunikation (1)
- Merkel cell carcinoma (1)
- Merkelzellkarzinom (1)
- Merogone experiments (1)
- Mesenchymal Stem Cell (1)
- Mesenchymal Stromal Cells (1)
- Mesogen (1)
- Metabolismus (1)
- Metabolomic Imaging (1)
- Metabolomics (1)
- Metallorganische Chemie (1)
- Metallosupramolekulare Chemie (1)
- Metanephrine (1)
- Metapleural gland (1)
- Metarhizium anisopliae (1)
- Methotrexate (1)
- Metrics (1)
- MicroRNAs (1)
- Minimally invasive vascular intervention (1)
- Mitgliedsstaaten (1)
- Mitochondria (1)
- Mitochondrium (1)
- MitraClip (1)
- Mobility (1)
- Mobilität (1)
- Mode propagation (1)
- Model comparison (1)
- Model simulation (1)
- Modellierung (1)
- Modenpropagation (1)
- Molecular biology (1)
- Molecular biophysics (1)
- Molecular neuroscience (1)
- Molecularly targeted therapy (1)
- Molekülzustand (1)
- Monetary Policy (1)
- Monocytes and macrophages (1)
- Motiliät (1)
- Motion detection (1)
- Motivation (1)
- Motivationspsychologie (1)
- Mrr1 (1)
- Multi-Hop Topologie (1)
- Multi-Hop Topology (1)
- Multicellular aggregates (1)
- Multifunctionalisability (1)
- Multiple Traits (1)
- Multipolar mitosis (1)
- Multizellulären Bakteriengemeinschaften (1)
- Muscidifurax (1)
- Muskelatrophie (1)
- Muskelzelle (1)
- Mutagenese (1)
- Mycobacterium tuberculosis (1)
- Mycobacterium tuberculosis InhA (1)
- Myokarditis (1)
- Myositis (1)
- N-MYC (1)
- N-heterocyclic carbenes (1)
- N6-methyladenosine (1)
- ND10 complex (1)
- NFATc1 (1)
- NIR-Spektroskopie (1)
- NK cells (1)
- NNLO (1)
- NOS-I (1)
- NOS1AP (1)
- NOX-Inhibitoren (1)
- NP-schweres Problem (1)
- NRF2 (1)
- NT-proBNP (1)
- NTHi (1)
- NaV1.9. oxidized phospholipids (1)
- Nahrungsaufnahme (1)
- Nanooptik (1)
- Nanopartikel (1)
- Nanoporöser Stoff (1)
- Nanosegregation (1)
- Nanostruktur (1)
- Nash-Gleichgewicht (1)
- Nasonia (1)
- Naturgefahr (1)
- Naturkatastrophe (1)
- Navigation analysis (1)
- Neostriatum (1)
- Nerve fibers (1)
- Nerve growth-factorcopy (1)
- Nestbau (1)
- Network Function Virtualization (1)
- Netzhaut (1)
- Netzwerktopologie (1)
- Neuroanatomie (1)
- Neurobiologie (1)
- Neurobiology (1)
- Neurodevelopment (1)
- Neuroendocrine (1)
- Neuroendocrine Tumor (1)
- Neurogenese (1)
- Neuronale Plastizität (1)
- Neutrino (1)
- Neutrino Telescope (1)
- Neutrino detectors (1)
- Neutrophils (1)
- Nichtlineares System (1)
- Nickelkomplexe (1)
- Niederdimensionales Elektronengas (1)
- Nierenfunktionsstörung (1)
- Non-coding RNA (1)
- Non-viral genome engineering (1)
- Nonlinear systems (1)
- Normetanephrine (1)
- Nosocomial Infections (1)
- Nosokomiale Infektionen (1)
- Notch1 (1)
- Notenbank (1)
- Nuclear (1)
- Nucleus accumbens (1)
- Numerical Methods (1)
- Numerical analysis (1)
- OCT1 (1)
- OPT (1)
- OSM (1)
- OSMR (1)
- Oberflächenplasmon (1)
- Oberflächenzustand (1)
- Obstruktive Ventilationsstörung (1)
- Olfaction (1)
- Oligomere (1)
- Oligomers and Polymers (1)
- Omega-3-Fettsäuren (1)
- Oncology (1)
- Oncostatin M (1)
- OncotypeDX\(^{®}\) (1)
- Onkogen (1)
- OpenFlow (1)
- OpsA (1)
- Optical spectroscopy (1)
- Optimale Steuerung (1)
- Optimierung (1)
- Optimierungsproblem (1)
- Optische Eigenschaft (1)
- Organische Synthese (1)
- Organometallic chemistry (1)
- Oryza sativa (1)
- Osmia (1)
- Osteoarthritis (1)
- P(P)over-bar collicions (1)
- P300 (1)
- PABPs (1)
- PAI-1 (1)
- PB-PB Collisions (1)
- PCI-32765 (1)
- PDE (1)
- PEST (1)
- PF-05231023 (1)
- PKCζ, (1)
- PML (1)
- PML nuclear-bodies (1)
- PMMA bone cement (1)
- PMNs (1)
- PP Collicions (1)
- PSMA (1)
- PSMA-RADS (1)
- PSMA-RADS-3A (1)
- PSMA-RADS-3B (1)
- PSMA-targeted PET (1)
- Paenibacterin (1)
- Pain (1)
- Pair Production (1)
- Pair Prodution (1)
- Pair-Production (1)
- Pan1 (1)
- Pancreas (1)
- Panel-Data Econometrics (1)
- Panelanalyse (1)
- Panic Disorder (1)
- Paniksyndrom (1)
- Paraganglioma (1)
- Parasite development (1)
- Parkinsonism (1)
- Parkinson’s disease (1)
- Partial Agonists (1)
- Partialagonismus (1)
- Particle dark matter (1)
- Particle production (1)
- Particle properties (1)
- Parton Ditributions (1)
- Pathogenität (1)
- Pathway (1)
- Peinlichkeit (1)
- Peptide (1)
- Period (1)
- Permeability (1)
- Permeabilität (1)
- Perturbative QCD (1)
- Pflanzen (1)
- Pflanzenbildgebung (1)
- Pharmaceutical Analysis (1)
- Phase Transition (1)
- Phospholipase D (1)
- Phospholipide (1)
- Phosphorescence (1)
- Photochemie (1)
- Photochemistry (1)
- Photoelektronenspektroskopie (1)
- Photon detectors for UV, visible and IR photons (vacuum) (1)
- Photons (1)
- Physiologically based kinetic models (1)
- Phänomenologische Soziologie (1)
- Plasmon (1)
- Plasmonic (1)
- Platelet (1)
- Plus (1)
- Plus Plus (1)
- Pollen (1)
- Pollinators (1)
- Poly(2-oxazolin)e (1)
- Poly(2-oxazoline)s (1)
- Poly(glycidol) (1)
- Polyatomare Verbindungen (1)
- Polycyclic aromatic hydrocarbons (1)
- Polycyclische Aromaten (1)
- Polyethylene glycol (1)
- Polyethylenglycol (1)
- Polypeptoide (1)
- Polypeptoids (1)
- Polysaccharide intercellular adhesin (PIA) (1)
- Polyspermy (1)
- Porphyrin (1)
- Positronenemissionstomografie (1)
- Post-transcriptional regulation (1)
- Postmarketing Experience (1)
- Practitioner's guide (1)
- Praktische Theologie (1)
- Preclinical (1)
- Prediction (1)
- Predictions (1)
- Preference for redistribution (1)
- Prevalence (1)
- Probiotikum (1)
- Production Cross-Section (1)
- Production cross-section (1)
- Prognostic impact (1)
- Programm (1)
- Progressive Relaxation (1)
- Proliferation (1)
- Propositional processing (1)
- Propositionale Verarbeitung (1)
- Prostatakrebs (1)
- Prostate cancer diagnostics (1)
- Protein (1)
- Protein folding (1)
- Protein kinase D1 (PKD1) (1)
- Proteinkinasen (1)
- Proteom (1)
- Proton-Proton- Collisions (1)
- Protonen-NMR-Spektroskopie (1)
- Protopterus annectens (1)
- Prototype (1)
- Pseudorapidity (1)
- Psychiatric disorders (1)
- Psychische Störung (1)
- Psychologie (1)
- Pteromalidae (1)
- Pump-Probe Technik (1)
- Pump-Probe-Technik (1)
- Punktwolke (1)
- Pyrenderivate (1)
- Pyrene (1)
- Pyrrolidinderivate (1)
- Pyrrolidine carboxamides (1)
- QCD Corrections (1)
- QoE Monitoring (1)
- Quality of Experience (1)
- Quanteninformatik (1)
- Quantentheorie (1)
- Quantum Spin Hall Effect (1)
- Quantum chromodynamics (1)
- Quark (1)
- Quark & gluon jets (1)
- Quark pair procuction (1)
- Quarkonium Production (1)
- Quarks (1)
- Quasi-1D Elektronensysteme (1)
- Quasi-Variational Inequality (1)
- Quasi-Variationsungleichung (1)
- RCT (1)
- REELS (1)
- REST-Complex (1)
- RGB-D (1)
- RNA Aptamer (1)
- RNA modification (1)
- RNA polymerase II (1)
- RNA sequencing (1)
- RNA-binding proteins (1)
- RNA-seq (1)
- RNS (1)
- RNase E (1)
- RSK (1)
- Ra-224 (1)
- Radiation calculations (1)
- Radionuclide Therapy (1)
- Radiotherapy (1)
- Raphe Kerne (1)
- Rapidity (1)
- Rashba effect (1)
- Rastertunnelmikroskopie (1)
- Raumdaten (1)
- Raumfüllung (1)
- Raumverhalten (1)
- Re-Annotation (1)
- Re-annotation (1)
- Reaction kinetics and dynamics (1)
- Receptors (1)
- Refugee Crisis (1)
- Registration (1)
- Regularisierung (1)
- Regulator of G protein signaling 2 (1)
- Regulatorischer Fokus (1)
- Regulatory T cells (1)
- Regulatory focus (1)
- Rekonstruktion (1)
- Relative Entropy (1)
- Release system (1)
- Remote Sensing (1)
- Renal abnormalities (1)
- Repair (1)
- Research design (1)
- Reservoir Strain (1)
- Resiliente Stadt (1)
- Resilienz (1)
- Resistance (1)
- Rezeptor (1)
- Rgs2 (1)
- Rho-Proteine (1)
- RhoGTPase (1)
- Rhodacyclopentadiene (1)
- Rhodobacter sphaeroides (1)
- Risikoanalyse (1)
- Risikomanagement (1)
- Risk assessment (1)
- Risk-factors (1)
- Ritual (1)
- River Basins (1)
- Robotics (1)
- Robotik (1)
- Root s=7 (1)
- Root-S=13 TEV (1)
- Rowing Ergometer (1)
- Ruthenium Komplexe (1)
- Räumliches Verhalten (1)
- Röntgen-Kleinwinkelstreuung (1)
- Röntgenstrukturanalyse (1)
- S1PR2 (1)
- SDN (1)
- SDN Controllers (1)
- SDN Switches (1)
- SIM (1)
- SLC2A3 (1)
- SNP (1)
- SNP-microarray (1)
- SOCE (1)
- SSTR-PET (1)
- STIM1 (1)
- STIM2 (1)
- SWOT (1)
- Scale (1)
- Schafgarbe <Gattung> (1)
- Schilddrüse (1)
- Schlaf (1)
- Schlaganfall (1)
- Schleuderguss (1)
- Schmerz (1)
- Schwann-cells (1)
- Science history (1)
- Sea urchin development (1)
- Selbst (1)
- Selbstorganisation (1)
- Semantic Search (1)
- Semantic Technologies (1)
- Semantic cognition (1)
- Semantische Analyse (1)
- Semantische Verarbeitung (1)
- Sensorimotor Rhythms (1)
- Sequenzanalyse <Chemie> (1)
- Serotonerge Nervenzelle (1)
- Serotonin (1)
- Sesquiterpene lactones (1)
- Sesquiterpenlactonen (1)
- Sglt1 (1)
- Shaggy kinase (1)
- Shigella flexneri (1)
- Shin-Metiu Model (1)
- Showers (1)
- Siberian spurge (1)
- Silibinin (1)
- Silibinin ester (1)
- Simulation methods and programs (1)
- Simulator (1)
- Single-Photon Detectors (1)
- Single-Photon-Emissions-Computertomographie (1)
- Single-molecule fluorescence microscopy (1)
- Sleeping Beauty transposon (1)
- Small RNA (1)
- Smart User Interaction (1)
- SnRK1 (1)
- Social Media (1)
- Social neuroscience (1)
- Society (1)
- Software (1)
- Software Defined Networking (1)
- Sonogashira (1)
- Sonogashira coupling (1)
- Sonogashira-Hagihara-Reaktion (1)
- Sox5 (1)
- Soziale Insekten (1)
- Soziale Mobilität (1)
- Sozialstaat (1)
- Soziologie (1)
- Sozioökonomisches System (1)
- Space filling (1)
- Sparse Sampling (1)
- Spatial behavior (1)
- Spatiotemporal analysis (1)
- Species Traits (1)
- Sphingomyelinase (1)
- Spinal nerves (1)
- Spinkette (1)
- Spintronik (1)
- Spleen tyrosine kinase (1)
- Spontaneous symmetry breaking (1)
- Sprue (1)
- Squarain Farbstoffe (1)
- Squaraine Dyes (1)
- Stability (1)
- Stabilität (1)
- Standardisierung (1)
- Staphylococci (1)
- Staphylococcus epidermidis (1)
- Star-shaped poly(ethylene glycol) (1)
- States (1)
- Statistical misconception (1)
- Statistische Hypothese (1)
- Stickstoffmonoxid-Synthase (1)
- Stiffness (1)
- Stimulating factor (1)
- Stofftransport <Biologie> (1)
- Strain Assessment (1)
- Streptomyces (1)
- Stress-Syndrom (1)
- Stressresistenz (1)
- Strong interaction (1)
- Structure-based (1)
- Strömung (1)
- Student (1)
- Super-resolution microscopy (1)
- Superpartners (1)
- Supraleitung (1)
- Supramolecular Chemistry (1)
- Surface plasmon (1)
- Surgery (1)
- Sustainability (1)
- Symmetries (1)
- Synaptische Proteine (1)
- Synaptonemal complex (1)
- Synovial Fluid Aspiration (1)
- Synthese (1)
- System (1)
- T cell acute lymphoblastic leukemia (1)
- T helper 1 cells (1)
- T-ALL (1)
- T-Lymphozyt (1)
- T-cell engineering (1)
- T-cell responses (1)
- T-cell therapy (1)
- T-lymphocytes (1)
- T. brucei (1)
- TAB08 (1)
- TFIIIC (1)
- TGF-β3 (1)
- TGN1412 (1)
- TK6 cells (1)
- TKI (1)
- TMJ (1)
- TRDV2 (1)
- TRGV9 (1)
- TRPA1 (1)
- TRPV1 (1)
- Tagesrhythmik (1)
- Talbot–Lau interferometer (1)
- Targeted Therapies (1)
- Targeted drug delivery (1)
- Targeted therapies (1)
- Tau leptons (1)
- Tauola (1)
- Taurolidine (1)
- Technical Documentation (1)
- Technische Unterlage (1)
- Testing parameter difference (1)
- Tetrazoliumsalze (1)
- Thalamic nuclei (1)
- Themenpark (1)
- Theologie (1)
- Theoretical Chemistry (1)
- Theoretische Chemie (1)
- Therapy (1)
- Thermografie (1)
- Thioether-Poly(glycidol) (1)
- Thrombopoese (1)
- Thrombopoiesis (1)
- Thrombosis (1)
- Thrombozytenaggregation (1)
- Tian Shan (1)
- Tiermodell (1)
- Time Series Analyses (1)
- Time-Resolved Spectroscopy (1)
- Timeless (1)
- Tiotropium (1)
- Tissue Engineering (1)
- Tissue engineering (1)
- Tn1549 transposon (1)
- Tn916-like transposon family (1)
- To-leading order (1)
- Tool (1)
- Top physics (1)
- Topological insulators (1)
- Training (1)
- Traits-Environment Relationships (1)
- Transkription (1)
- Transkription <Genetik> (1)
- Transkriptionsfaktor (1)
- Transkriptom (1)
- Translational research (1)
- Transparent motion (1)
- Transpiration barrier (1)
- Transporters (1)
- Transportkoeffizient (1)
- Transportprozess (1)
- Transposon (1)
- Transverse-momentum (1)
- Treatment (1)
- Treatment outcome (1)
- Trichomalopsis (1)
- TrkB (1)
- Tropomyosin receptor kinase B (1)
- Trypanosoma (1)
- Trypanosoma brucei brucei (1)
- Trypanosomes (1)
- Tuberkelbakterium (1)
- Tumor Microenvironment (1)
- Tumour angiogenesis (1)
- Tunnelspektroskopie (1)
- Two-dimensional Spectroscopy (1)
- UAV (1)
- UV-VIS-Spektroskopie (1)
- UV/Vis spectroscopy (1)
- UWB (1)
- Ultrafast information processing (1)
- Ultrakurzer Lichtpuls (1)
- Ultraschnelle Informationsverarbeitung (1)
- Ultraschnelle Photochemie (1)
- Umverteilungspräferenz (1)
- Universität Würzburg. Lehrstuhl für Pharmazeutische Technologie und Biopharmazie (1)
- Urbane Resilienz (1)
- Ureaplasma species (1)
- Usage (1)
- Utility (1)
- V800 (1)
- VEMP (1)
- VSG (1)
- VSMC (1)
- Valvular heart-desease (1)
- Variables Oberflächen Glycoprotein (1)
- Variant surface glycoprotein (1)
- Variationsungleichung (1)
- Varieties of Democracy (1)
- Venusfliegenfalle (1)
- Verallgemeinertes Nash-Gleichgewichtsproblem (1)
- Vergütung (1)
- Verhalten (1)
- Verkehrspsychologie (1)
- Verteilungspolitik (1)
- Viral infections (1)
- Virtualisierung (1)
- Viscosity (1)
- Voltage-Clamp-Methode (1)
- Vγ9Vδ2 (1)
- WTAP (1)
- Wasser Fett Trennung (1)
- Wasseroxidation (1)
- Weakly interacting massive particles (1)
- Web navigation (1)
- Well-Balanced (1)
- Well-posedness (1)
- Wellenleiter (1)
- Westafrika (1)
- Wild bees (1)
- Wire relaxation (1)
- Wirkstofffreisetzung (1)
- Wirtschaftsentwicklung (1)
- Wirtschaftsstruktur (1)
- Wirtschaftswachstum (1)
- Wissenschaftliche Literatur (1)
- Währungsunion (1)
- X-ray imaging (1)
- XPS (1)
- Xenophon (1)
- Xenopus laevis oocytes (1)
- Z Boson (1)
- ZDF rats (1)
- ZO-1 (1)
- Zahlentheorie (1)
- Zeitaufgelöste Spektroskopie (1)
- Zeitauflösung (1)
- Zellbiologie (1)
- Zelldifferenzierung (1)
- Zelloberfläche (1)
- Zellteilung (1)
- Zika virus (1)
- Zinsänderungsrisiko (1)
- Zwei-Prozess-Modell (1)
- Zweidimensionale Spektroskopie (1)
- [68Ga]DOTATOC (1)
- \(^{18}\)F-FDG (1)
- \(^{18}\)F-fluorodeoxyglucose (1)
- \(^{99m}\)Tc-MAG3 (1)
- ab initio calculations (1)
- absorbed dose (1)
- absorbed dose to the blood (1)
- acetone (1)
- acquisition of host regulators (1)
- acrophobia (1)
- action potentials (1)
- active galactic nuclei (1)
- activity rhythms (1)
- activity tracker (1)
- acute myeloid leukemia (1)
- adaptive role (1)
- additive manufacturing (1)
- adrenal insufficiency (1)
- adsorption (1)
- adsorption-induced deformation (1)
- adult (1)
- adult treatment (1)
- advanced drug delivery system (1)
- aerobic fitness (1)
- aerobic training (1)
- affect (1)
- age-related macular degeneration (1)
- agricultural intensity (1)
- agricultural productivity (1)
- agroecology (1)
- airborne laser scanning (ALS) (1)
- airflow (1)
- alcohol (1)
- alkaloids (1)
- allogeneic stem cell transplantation (1)
- allosterism (1)
- allotype (1)
- alpha particles (1)
- altruism (1)
- altruistic compensation (1)
- altruistic punishment (1)
- aluminum copper alloys (1)
- amino acid analysis (1)
- amount of invested mental effort (1)
- amygdala (1)
- anaphylatoxins (1)
- anemia (1)
- aneurysm (1)
- anger (1)
- angiotensin II type 1 receptor (1)
- animal behaviour (1)
- anti-hiv agents (1)
- anti-infective vaccination (1)
- anti-inflammatory (1)
- anti-microbial activit (1)
- anti-retroviral agents (1)
- antibacterial activity (1)
- antibiotic resistance (1)
- anticoagulants (1)
- anticoagulation (1)
- antidepressant (1)
- antigenic recall (1)
- antimicrobials (1)
- antioxidants (1)
- anuria (1)
- aphasia (1)
- approximation algorithm (1)
- aqua material (1)
- arachidonic acid metabolic network (1)
- arial fibrillation (1)
- arousal (1)
- arrhythmia (1)
- arterial hypotension (1)
- artificial diet (1)
- artificial intelligence (1)
- aspergillosis (1)
- assay (1)
- assessment of cognitive disorders/dementia (1)
- assortative mating (1)
- asymmetry (1)
- athletes (1)
- atmospheric chemistry (1)
- atomistic models (1)
- atrial fibrillation (1)
- attention bias (1)
- attention-deficit/hyperactivity disorder (1)
- atypical chemokine receptor 3 (1)
- autoantibodies (1)
- autoimmune antibodies (1)
- autoimmunity (1)
- autologous stem cell transplantation (1)
- automated driving (1)
- autosomal recessive non-synstromic hearing loss (1)
- auxin (1)
- axonal degeneration (1)
- bPAC (1)
- bSSFP (1)
- bZIPs (1)
- bacteria (1)
- bacterial genomics (1)
- bacterial transcription (1)
- bakanae (1)
- balanced steady state free precession (1)
- bank credit market (1)
- banking (1)
- bariatric surgery (1)
- barium titanate (1)
- basal ganglia (1)
- bee disease (1)
- beech forests (1)
- behavior (1)
- behavioral conditioning (1)
- behavioral rhythms (1)
- behavioral transition (1)
- behaviour (1)
- behaviour therapy (1)
- bi-compartmental (1)
- bi-compartmental knee arthoplasty (1)
- big data (1)
- bile (1)
- bioactive peptide (1)
- bioassays (1)
- bioconjugation (1)
- biodegradable implant (1)
- biodiversity (1)
- biodiversity estimation (1)
- biofabrication (1)
- biofeedback (1)
- biogeochemistry (1)
- biokinetics (1)
- biological dosimetry (1)
- biological pest control (1)
- biologics (1)
- biomarker (1)
- biomedical applications (1)
- biomedical engineering (1)
- biomedicine (1)
- bioprinting (1)
- bioreactor (1)
- bioresponsive (1)
- bird diversity (1)
- bitopic ligand (1)
- black woodpecker (1)
- blocking opsonization (1)
- blood (1)
- blood glucose regulation (1)
- blood-nerve barrier (1)
- body composition (1)
- bond activation (1)
- bond market (1)
- bone development (1)
- bone marrow niche (1)
- bone morphogenetic protein (1)
- boron chains (1)
- boronium cations (1)
- borylation (1)
- borylenes (1)
- brain metastasis (1)
- brain stimulation (1)
- brood rearing (1)
- building behavior (1)
- butyrophilin 3 (1)
- butyrophilins (1)
- cAMP (1)
- caffeine (1)
- calcium phosphate (1)
- calcium phosphate cement (1)
- cancer models (1)
- cancer risk (1)
- canonical microcircuits (1)
- capecitabine (1)
- capsaicin (1)
- carabid beetles (1)
- carbanion (1)
- carbene-stabilized nickel complexes (1)
- carbohydrates (1)
- carbon fiber reinforcement (1)
- cardiac device therapy (1)
- cardiac innervation imaging (1)
- cardiac nerve (1)
- cardiac surgery (1)
- cardiac sympathetic nerve system (1)
- cardiac sympathetic nervous system (1)
- cardiomyopathy (1)
- cardiovascular disease (1)
- cardiovascular morbidity (1)
- cardiovascular mortality (1)
- career self-management (1)
- careers (1)
- carmine (1)
- cartilage tissue engineering (1)
- catalysis (1)
- cataracts (1)
- ceftriaxone (1)
- cell growth (1)
- cell membranes (1)
- cell wall channel (1)
- cell wall synthesis (1)
- cellular stress responses (1)
- cellular waveform (1)
- center of pressure (1)
- centrifugally casting (1)
- ceramides (1)
- chain structures (1)
- chalcogens (1)
- channel (1)
- chelates (1)
- chemical bonding (1)
- chemical communication (1)
- chemical ecology (1)
- chemotherapy (1)
- child (1)
- children/adults (1)
- chlamydia (1)
- chlamydia serine proteases (1)
- chlamydial inclusion (1)
- chlamydomonas reinhardtii (1)
- chlamyopsin (1)
- cholinergic system (1)
- chromatin (1)
- chronic constriction injury (1)
- chronophin (1)
- cicatricial pemphigoid (1)
- circadian clocks (1)
- cirrhosis (1)
- claudin-1 (1)
- click chemistry (1)
- climate change (1)
- climate control (1)
- climate scenarios (1)
- climate-change (1)
- co-delivery (1)
- coaptation line (1)
- cochlear nucleus (1)
- coevolution (1)
- cofilin (1)
- cognition (1)
- cognitive balance (1)
- cognitive dissonance (1)
- cognitive neuropsychology in dementia (1)
- coherence (1)
- cohesin (1)
- collagen-glycosaminoglycane matrix (CGM) (1)
- colon cancer (1)
- color vision (1)
- coloration (1)
- comparison (1)
- complement (1)
- complement system (1)
- complex (1)
- complexity (1)
- complications (1)
- compound eyes (1)
- compressive strength (1)
- computational modelling (1)
- conditional sex allocation (1)
- conditioned response (1)
- condyle pathomorphology (1)
- conical intersections (1)
- conjugated polymers (1)
- conjugative transposition (1)
- conjunctival defect (1)
- conjunctival hole (1)
- conjunctival repair (1)
- consciousness (1)
- content cluster (1)
- content-analysis (1)
- control-focused democracy (1)
- convergent star product (1)
- copeptin (1)
- copy number variation (1)
- corneal endothelium (1)
- corneal epithelium (1)
- corneal storage (1)
- coronary artery disease (1)
- correlative methods (1)
- costs (1)
- crop (1)
- crop diversity (1)
- cross-talk (1)
- cryostructuring (1)
- cryptochrome (1)
- crystal structure (1)
- crystallography (1)
- culturable command area (1)
- cyclic (alkyl)(amino) carbenes (1)
- cycloaddition (1)
- cylic GMP (1)
- cystic fibrosis (1)
- cytarabine dose (1)
- cytokine (1)
- cytokine secretion (1)
- cytotoxic T cells (1)
- dMyc (1)
- dSTORM (1)
- damage tolerant cement (1)
- darkfield imaging (1)
- data science (1)
- dead spot (1)
- dead tree (1)
- deadwood (1)
- debris-covered glaciers (1)
- decay (1)
- decision making (1)
- defense (1)
- deformation (1)
- deformation quantization (1)
- delayed cerebral infarction (1)
- democracy (1)
- density functional theory (1)
- deoxyribozymes (1)
- depolarization (1)
- derivatives (1)
- dermatology (1)
- desymmetrization (1)
- diabetes (1)
- diabetes insipidus (1)
- diabetes mellitus (1)
- diabetic cardiomyopathy (1)
- diagnosis (1)
- diboranes (1)
- diboration (1)
- diboron (1)
- diboryne (1)
- dietary approaches to stop hypertension (1)
- differentiation (1)
- digitalization (1)
- dilatometer (1)
- direct anterior approach (1)
- disease genetics (1)
- disfluency (1)
- dispersal (1)
- distal radio-ulnar joint (1)
- distance measurement (1)
- distributary (1)
- distribution modulo one (1)
- dmP53 (1)
- dog microbiome (1)
- dogs (1)
- dorsal instrumentation (1)
- dosimetry (1)
- double-stranded (1)
- drainage tube (1)
- driver behavior (1)
- driver distraction (1)
- drug design (1)
- drug discovery (1)
- drug regulation (1)
- drug-induced immune hemolytic anemia (1)
- dry lung syndrome (1)
- dualsteric ligand (1)
- dyes (1)
- dynamic (1)
- eHealth (1)
- early neural precursors (1)
- early-life stress (1)
- eco-metabolomics (1)
- ecological intensification (1)
- ecology (1)
- economics (1)
- ecosystem services (1)
- educational psychology (1)
- educational tool (1)
- efficacy (1)
- egalitarian democracy (1)
- elderly (1)
- electrical and electronic engineering (1)
- electroencephalogram (1)
- electrometer (1)
- electronic properties and materials (1)
- electrophiles (1)
- elektronisch angeregte Zustände (1)
- elution (1)
- emergence (1)
- emotion processing (1)
- emotion regulation (1)
- endocytosis (1)
- endometriosis (1)
- endophytic fungi (1)
- endophytische Pilze (1)
- endoreplication (1)
- endothelial cells (1)
- endovascular repair (1)
- energy metabolism (1)
- energy transfer (1)
- enoyl ACP reductase (1)
- entrepreneurship (1)
- entropy inequality (1)
- environmental degradation (1)
- environmental sciences (1)
- enzyme activator (1)
- episcleral drainage device (1)
- erovalent diboron compounds (1)
- error estimate (1)
- erythrocyte adherence (1)
- evaluation (1)
- event (1)
- exaptation (1)
- exclusion criteria (1)
- exercise intervention (1)
- expansion (1)
- experience taking (1)
- expression (1)
- extended Kalman filter (1)
- extinction (1)
- extra cellular matrix (1)
- extremity trauma (1)
- eye tracking (1)
- eyetracking (1)
- fMRI (1)
- failure (1)
- fast decay (1)
- fatigue (1)
- fear behavior (1)
- fear conditioning (1)
- feral honey bees (1)
- fermentation (1)
- ferroptosis (1)
- fiber–matrix interaction (1)
- fibroblast growth factor (1)
- field testing (1)
- finite volume method (1)
- flagellate (1)
- flame test (1)
- fluorescent protein (1)
- fluorescent resonance energy transfer (1)
- flupyradifurone (1)
- flux distributions (1)
- flytrap (1)
- foliar fungal community (1)
- food security (1)
- foreign companies (1)
- fracture (1)
- fracture-associated vascular damage (1)
- free energy (1)
- frequency modulation (1)
- frontal cortex (1)
- frontotemporal dementia (1)
- frühe neurale Vorläufer (1)
- fullerene network (1)
- functional genetics (1)
- functional genomics (1)
- functional mitral regurgitation (1)
- functional near-infrared spectroscopy (1)
- functional regurgitation (1)
- functional training (1)
- fungal biology (1)
- fungal endophytes (1)
- fungal rhodopsins (1)
- fungicidal activity (1)
- fungus-farming insects (1)
- fungus-plant interaction (1)
- gametogenesis (1)
- gamma gamma channel (1)
- gels and hydrogels (1)
- gender gap (1)
- gene expression (1)
- gene transfer (1)
- gene-expression (1)
- genetic association study (1)
- genetic linkage study (1)
- genome annotation (1)
- genotype (1)
- genotype-phenotype patterns (1)
- genotyping arrays (1)
- germinal center (1)
- germline mutations (1)
- glaciers (1)
- glaucoma drainage device (1)
- glioblastoma multiforme (1)
- glioma (1)
- glucose transporter (1)
- glycoprotein GPV (1)
- gp130 (1)
- granulocytes (1)
- graphs (1)
- grating interferometer (1)
- green light perception (1)
- green systems biology (1)
- ground dwelling predators (1)
- groundwater (1)
- group change (1)
- growth hormone deficiency (1)
- growth pattern (1)
- guanylyl cyclase-A (1)
- guidelines (1)
- gut microbiome (1)
- habitat requirements (1)
- habitat suitability model (HSM) (1)
- haematopoietic stem cells (1)
- half-life (1)
- half-sandwich complexes (1)
- halothane (1)
- hardness (1)
- health care payers (1)
- health promotion (1)
- healthy volunteers (1)
- heart failure (1)
- heart failure with mid-range ejection fraction (1)
- helminths (1)
- hemolysis (1)
- hemorrhagic stroke (1)
- hepatitis C virus (1)
- hereditary breast and ovarian cancer (1)
- hereditary hearing loss (1)
- hibernation (1)
- hierarchical matrix (1)
- high performance liquid chromatography (1)
- high-intensity interval training (1)
- hip (1)
- hippocampus (1)
- histones (1)
- history (1)
- hollow tree (1)
- homogeneous catalysis (1)
- honey bees (1)
- host screening (1)
- hub genes (1)
- human (1)
- human behaviour (1)
- human body weight (1)
- human brain microvascular endothelial cells (1)
- human herpesvirus 6 (1)
- human learning (1)
- human microbiome (1)
- human primary cells (1)
- human-automation interaction (1)
- human-computer interaction (1)
- humans (1)
- hyaluronic acid (1)
- hybrid molecules (1)
- hybrid pacemaker (1)
- hydrodynamic limits (1)
- hydrogel (1)
- hydrogenation (1)
- hydrological modelling (1)
- hydroxyephedrine (1)
- hypertension (1)
- hyphae (1)
- hypothalamus (1)
- icaADBC (1)
- identification (1)
- identity integration (1)
- illumina (1)
- image processing (1)
- imaginary quadratic field (1)
- imaging (1)
- iminoboranes (1)
- immersion (1)
- immune cells (1)
- immune reconstitution (1)
- immunoglobulin superfamily (1)
- immunosuppression (1)
- impact force (1)
- impervious surface areas (1)
- implant fit (1)
- implant positioning (1)
- implants (1)
- implicit motives (1)
- impulse control disorders (1)
- in situ analysis (1)
- in situ forest monitoring (1)
- in vitro contracture test (1)
- in vitro selection (1)
- in-vitro (1)
- inactivity (1)
- index analysis (1)
- individualised modular treatment programme (1)
- individualized training (1)
- indole-3-acetic acid (IAA) (1)
- indoxyl sulfate (1)
- infinium HumanOmni1-Quad (1)
- inflammation mediators (1)
- inflammatory pain (1)
- information technology (1)
- injectable protein formulation (1)
- injury prevention (1)
- innate immune response (1)
- insect vision (1)
- insect-fungus mutualism (1)
- insecticides (1)
- insertion-site deep sequencing (1)
- insulin receptor (1)
- insulin-like growth factor 1 receptor (1)
- integrated optics (1)
- inter-rater reliability (1)
- interest rate risk (1)
- interface control (1)
- intergenerational contraction (1)
- intergroup bias (1)
- internet of things (1)
- interobserver (1)
- interreader (1)
- intervalence charge transfer (1)
- intervention (1)
- invasive disease (1)
- inventory (1)
- inverse parameterization (1)
- ionizing radiation (1)
- irrigation pricing (1)
- ischemia-reperfusion injury (1)
- ischemic (1)
- ischemic stroke (1)
- islets of Langerhans (1)
- isomers (1)
- jasmonate (1)
- joint aspiration (1)
- juvenile idiopathic arthritis (1)
- ketogenic diet (1)
- ketone bodies (1)
- killing (1)
- kinect (1)
- kinetic description of gases (1)
- knee (1)
- knee alignment (1)
- knee osteoarthritis (1)
- laboratory measurements (1)
- lambdoid prophage (1)
- laminin 332 (1)
- land surface temperature (1)
- landscape heterogeneity (1)
- laparoscopic right colectomy (1)
- large Stokes shift (1)
- laser scanner (1)
- laserscanner (1)
- latency (1)
- leaf-cutting ants (1)
- leaflet (1)
- learning (1)
- leukocytes (1)
- level of evidence: IV (1)
- levosimendan (1)
- libertarian democracy (1)
- lifetime spectroscopy (1)
- limbic system (1)
- linked open data (1)
- lipid bilayer membrane (1)
- lipid rafts (1)
- lipochitinoligosaccharides (1)
- literature review (1)
- liver diseases (1)
- liver oligometastases (1)
- loanable funds theory (1)
- localization microscopy (1)
- locus coeruleus (1)
- locus coerulus (1)
- low Mach number (1)
- low-cost spectrometer (1)
- low-valent main group chemistry (1)
- lymph nodes (1)
- lysosomal storage disorder (1)
- lytic replication (1)
- mHealth (1)
- mRNA (1)
- macrophages (1)
- macrophages immunobiology (1)
- magnesium (1)
- magnetic resonance imaging (1)
- main-group chemistry (1)
- major depression (1)
- major depressive disorder (1)
- malignant hyperthermia (1)
- mapping (1)
- marine biology (1)
- market entry decisions (1)
- mass (1)
- mass casualties (1)
- mass spectrometry (1)
- master sex-determining gene (1)
- mate recognition (1)
- matrix metalloproteases (1)
- measurement of democracy (1)
- medaka (1)
- medical (1)
- medical genetics (1)
- medical research (1)
- medicinal plants (1)
- medicine authentication tools (1)
- meiosis (1)
- melt electrospinning (1)
- melt electrowriting (1)
- membrane potential (1)
- membrane proteins (1)
- meningitis (1)
- mental disorders (1)
- mental representation (1)
- metabolic modeling (1)
- metabolic pathways (1)
- metabolic profile (1)
- metabolism (1)
- metacognitive control (1)
- metacognitive judgments (1)
- metacognitive monitoring (1)
- metacomprehension (1)
- metagenomics (1)
- metallosupramolecular chemistry (1)
- mevalonate pathway (1)
- miR-146a (1)
- miR-193a (1)
- miR-26 (1)
- miRNA Biogenesis (1)
- micro pattern gaseous detectors (1)
- micro-ionization chambers (1)
- microRNA (1)
- microbial ecology (1)
- microbiome (1)
- microbot (1)
- microdialysis (1)
- microenvironment (1)
- micromegas detectors (1)
- micronuclei (1)
- microrna (1)
- microscopy (1)
- microswimmer (1)
- mild (1)
- milk proteins (1)
- mineralization (1)
- minimal invasive surgery (1)
- minimally invasive (1)
- mitigation strategies (1)
- mitochondrial morphology (1)
- mitral valve (1)
- mixed hearing loss (1)
- mobile apps (1)
- model (1)
- model organism (1)
- modeling (1)
- moderate sedation (1)
- module (1)
- molecular docking (1)
- molecular dynamics (1)
- molecular radiotherapy (1)
- monetary economy (1)
- monitoring (1)
- monoamine oxidase A (1)
- monocyte-platelet aggregates (1)
- mood (1)
- mood induction (1)
- mortality (1)
- motility (1)
- mouse (1)
- mouse microbiome (1)
- mouse platelets (1)
- movement ecology (1)
- moycardial sympathetic innervation (1)
- mucous membrane pemphigoid (1)
- multi-fluid mixture (1)
- multi-source forest health monitoring network (1)
- multidrug-resistant bacteria (1)
- multigene-array (1)
- multigrid (1)
- multimodal fusion (1)
- multimodal interface (1)
- multiple bonds (1)
- multiplicity of infection (1)
- muon spectrometer (1)
- muscarinic receptors (1)
- muscle (1)
- mutualism (1)
- mycobacteria (1)
- mycolic acid (1)
- myocardial nerve (1)
- myocardial perfusion imaging (1)
- myocarditis (1)
- nanostructured (1)
- nanowires (1)
- narratives (1)
- natriuretic peptides (1)
- natural interfaces (1)
- natural variation (1)
- navigation (1)
- ncRNA (1)
- near-infrared spectroscopy (1)
- neoepitope-derived peptides (1)
- neonatal renal failure (1)
- nest climate (1)
- net testing effect (1)
- network (1)
- networking (1)
- neural circuits (1)
- neural stem cells (1)
- neuroepithelial progenitors (1)
- neuroepitheliale Vorläufer (1)
- neurogenesis (1)
- neuroinflammation (1)
- neuronal dysfunction (1)
- neuronal nitric oxide synthase (1)
- neuronale Stickstoffmonoxidsynthase (1)
- neuropathic pain (1)
- neuropeptide (1)
- neuroprotection (1)
- neuroprotective (1)
- neuropsychiatric disorders (1)
- neuropsychiatrische Störungen (1)
- neutral sphingomyelinase 2 (1)
- neutrophils (1)
- nicht-viraler Gentransfer (1)
- nicotinic receptors (1)
- nine-banded armadillo (1)
- non-coding RNA (1)
- non-nucleoside reverse transcriptase inhibitors (1)
- non-responder (1)
- nonadiabatic dynamics (1)
- norepinephrine (1)
- nucleosides (1)
- nuclesosome positioning (1)
- nucleus accumbens (1)
- null hypothesis testing (1)
- nutrients (1)
- object-based image analysis (1)
- objective assessment (1)
- oesophagogastroduodenoscopy (1)
- olfaction (1)
- oligo-recurrence (1)
- oligohydramnios sequence (1)
- oligometastases (1)
- ologen implant (1)
- omega-3 fatty acids (1)
- optical remote sensing (1)
- optimal control (1)
- optimal control problem (1)
- oral anticancer drugs (1)
- organic electronics (1)
- organometallic chemistry (1)
- osmotic stimulation (1)
- osteochondral implant (1)
- outcome (1)
- outpatients (1)
- ovarian cancer (1)
- ovary (1)
- oxidierte Phospholipide (1)
- p-cresyl sulfate (1)
- p-value (1)
- pacemaker neuron (1)
- pancreatic carcinoma (1)
- paraganglioma (1)
- parasite (1)
- parent training (1)
- partial differential equation (1)
- partial integro-differential equations (1)
- partially-supervised (1)
- patch-clamp (1)
- pathogen vector (1)
- patient-doctor-relationship (1)
- patient-specific (1)
- pea aphid (1)
- peak oxygen uptake (1)
- pediatric patients (1)
- peer review (1)
- pelvic trauma (1)
- pemphigoid (1)
- pemphigus (1)
- penetrance (1)
- peptidase inhibitor PI15 (1)
- peptide receptor (1)
- peptide receptor radionuclide therapy (1)
- peptide synthesis (1)
- perception (1)
- percutaneous mitral valve repair (1)
- periodization (1)
- peripheral nervous system (1)
- permeation and transport (1)
- pesticide (1)
- phaeochromocytoma (1)
- phagocytosis (1)
- pharmacology (1)
- phase IV (1)
- phase contrast imaging (1)
- phase stepping (1)
- phase transitions and critical phenomena (1)
- phenological response (1)
- phenological shift (1)
- phenols (1)
- phenotype (1)
- pheochromocytoma (1)
- phosphine ligands (1)
- phosphoantigens (1)
- phospholipase D (1)
- photodynamics (1)
- photoelectron spectroscopy (1)
- photoreceptor (1)
- phototransduction (1)
- phototrophic growth (1)
- phylogenomics (1)
- physical fitness (1)
- phytochemicals (1)
- pi-conjugation (1)
- picture comprehension (1)
- pig microbiome (1)
- pigment epithelium derived factor (1)
- pigment pattern (1)
- pigment-dispersing factor (1)
- pigs (1)
- pilot-point-approach (1)
- placental mammals (1)
- plant-insect-microbe interactions (1)
- plasma cells (1)
- plasma modelling (1)
- plasmablasts (1)
- plasmonics (1)
- platelet (1)
- platelet biogenesis (1)
- polarity (1)
- polarization (1)
- policy (1)
- politics (1)
- polity (1)
- pollen (1)
- pollination (1)
- pollinator interactions (1)
- polyatomic molecules (1)
- polymer processing (1)
- polymorphonuclear neutrophils (1)
- population density (1)
- porin (1)
- pose estimation (1)
- potassium (1)
- potter sequence (1)
- power training (1)
- precipitates (1)
- preclinical research (1)
- predictor analysis (1)
- prejudice (1)
- premutation (1)
- presence (1)
- pressure sensor (1)
- preterm (1)
- prevalence (1)
- prevention (1)
- prezygotic reproductive isolation (1)
- primary polydipsia (1)
- prime number (1)
- probability of scoring a goal (1)
- probiotica (1)
- procedural fusion methods (1)
- processing speed (1)
- profile of democracy (1)
- progenitors (1)
- prognosis (1)
- program (1)
- proliferation (1)
- propionic acid (1)
- prospective (1)
- prospective study (1)
- prostate-specific membrane antigen (1)
- prostate-specific membrane antigen (PSMA) (1)
- protease-sensitive release (1)
- protein and mRNA expression (1)
- protein hydrolysis (1)
- protein maturation (1)
- protein modification (1)
- protein therapeutics (1)
- proteolipid protein (1)
- proton-proton collision (1)
- proton-proton collisions (1)
- psychologists (1)
- psychometrics (1)
- public health medicine (1)
- pulse simulation (1)
- pyrrolidine carboxamides (1)
- quality assurance (1)
- quality evaluation (1)
- quality indicators (1)
- quality of democracy (1)
- quantification (1)
- quantitative analysis (1)
- quantitative imaging (1)
- question format (1)
- questionnaire (1)
- rac1 inhibitors (1)
- radiation effects (1)
- radiation response (1)
- radionuclide therapy (1)
- radium (1)
- random forest (1)
- randomised controlled trial (1)
- ras (1)
- rat hippocampal neurons (1)
- reaction time (1)
- rearrangement (1)
- recategorization (1)
- recombinant DNA (1)
- reconstruction (1)
- recurrence (1)
- redox reactions (1)
- regenerative medicine (1)
- regression analysis (1)
- regularization (1)
- regulatory T cells (1)
- relative dosimetry (1)
- remote sensing (1)
- renal failure (1)
- renal tubular dysgenesis (1)
- renin-angiotensin system (1)
- repeated exercise (1)
- repeated sprint running (1)
- reporting and data system (1)
- reporting and data systems (1)
- rescue mission (1)
- research software (1)
- resistive micromegas (1)
- resource mapping (1)
- resource suitability (1)
- respiratory distress (1)
- retinal development (1)
- retinal pigment epithelium (1)
- retrieval practice (1)
- reverse transcriptase inhibitors (1)
- revision (1)
- rice–plant infection (1)
- ring-barking (1)
- risk assessment (1)
- robotic (1)
- rodent model (1)
- rotator cuff (1)
- rule discovery (1)
- ruthenium complexes (1)
- salivary alpha-amylase (1)
- salivary gland (1)
- sampling method (1)
- sarcoidosis (1)
- scaffold (1)
- scapula (1)
- scatter radiation (1)
- scientists (1)
- seahorse (1)
- search (1)
- second-tier cities (1)
- secretion (1)
- sedentary lifestyle (1)
- segmentation (1)
- selective retina therapy (1)
- selectivity (1)
- self-concept (1)
- self-reactivity (1)
- semantic fusion (1)
- semantic web (1)
- semiconductor devices (1)
- senescence (1)
- sensitivity analysis (1)
- sensorineural hearing loss (1)
- sensory cues (1)
- sensory neuropathy (1)
- sepsis (1)
- sex chromosomes (1)
- sex differentiation (1)
- sexual conflict (1)
- sexually antagonistic genes (1)
- signal integration (1)
- signal processing (1)
- signal transduction (1)
- significance testing (1)
- signs and symptoms (1)
- silk fibroin scaffolds (1)
- simulation (1)
- single photon emission computed tomography: sympathetic nerve (1)
- single top quark (1)
- single-wall carbon nanotubes (1)
- six-minute walk test (1)
- skeletal dysplasia (1)
- skeletal muscle (1)
- skin conduction response (1)
- small-molecule activation (1)
- smart soccer boot (1)
- smartwatch (1)
- snags (1)
- social bees (1)
- social capital (1)
- social comparison (1)
- social identification (1)
- social interaction (1)
- soil and water conservation (1)
- soil erosion (1)
- somatostatin receptor (SSTR) (1)
- somatostatin receptors (1)
- spacer (1)
- speciation (1)
- species interactions (1)
- species richness (1)
- spectral sensitivity (1)
- specular reflective (1)
- spiders (1)
- spin-orbitronics (1)
- spinal cord injury (1)
- spine trauma (1)
- spintronic (1)
- splicing (1)
- standardization (1)
- standing deadwood (1)
- staphylinid beetles (1)
- state-based model (1)
- statins (1)
- statistical significance (1)
- steady-state dendritic cells (1)
- stem cells (1)
- stereotactic body radiotherapy (1)
- storage vesicle turnover (1)
- store-operated calcium entry (1)
- streptozotocin (1)
- structure elucidation (1)
- structure-activity relationship (1)
- students (1)
- study system (1)
- stx-Phagen (1)
- stx-phages (1)
- subarachnoid hemorrhage (1)
- subphenotypes (1)
- substandard and falsified medicines (1)
- substantia nigra (1)
- supervisors (1)
- support vector machines (1)
- supramolecular chemistry (1)
- surface reflectances (1)
- surgical trauma room (1)
- surveillance (1)
- survey (1)
- sustainability (1)
- sustainable irrigation system (1)
- swarming (1)
- sweat osmolality (1)
- sweat secretion rate (1)
- sweet spot (1)
- symmetries (1)
- sympathetic nervous system (1)
- synapse (1)
- synaptic proteins (1)
- synaptic vesicles (1)
- sync-oligometastases (1)
- synthetic methodology (1)
- systemic micro-inflammation oxidative stress (1)
- tDCS (1)
- tVNS (1)
- tanzania (1)
- task complexity (1)
- taste (1)
- teleost fish (1)
- telephone-assisted self-help (1)
- temperate zones (1)
- temporal organization (1)
- tenting (1)
- teriflunomide (1)
- terror attack (1)
- testing effect (1)
- testis (1)
- text comprehension (1)
- the microtubule-organizing center (1)
- theme park (1)
- theoretical calculations (1)
- theory and computation (1)
- therapeutic approach (1)
- therapeutic vaccines (1)
- thermal camera (1)
- thermal stresses (1)
- thermoregulation (1)
- three-dimensional echocardiography (1)
- three-toed woodpecker (Picoides tridactylus) (1)
- thyroid stimulating hormone receptor (1)
- tight junction protein (1)
- tight junctions (1)
- tikhonov regularization (1)
- timing (1)
- tissue culture (1)
- tolerogenic dendritic cells (1)
- topological insulator (1)
- topological insulators (1)
- topological superconductor (1)
- total hip arthroplasty (1)
- toxicology (1)
- track and trace (1)
- trade-off (1)
- trafficking pathways (1)
- trail making test (1)
- training curriculum (1)
- training intensity (1)
- trans-Golgi network (1)
- transcriptional profiling (1)
- transcriptional rewiring (1)
- transcriptional termination (1)
- transcriptome (1)
- transcriptomics (1)
- transgluteal approach (1)
- transient absorption spectroscopy (1)
- transition metal complex (1)
- translational research (1)
- transparent (1)
- transport coefficients (1)
- transportation (1)
- treated metastases control (1)
- tree cavity (1)
- triple-negative breast cancer (1)
- trypanobot (1)
- trypanosoma (1)
- tsetse (1)
- tumor (1)
- tumor infiltrating lymphocytes (1)
- two-color microscopy (1)
- two-component system (1)
- two-dimensional electron gas (1)
- type 2 (1)
- type II esophageal achalasia (1)
- tyrosine recombinase (1)
- uPA (1)
- ubiquitin (1)
- ulnar-shortening osteotomy (1)
- ultrafast photochemistry (1)
- ultrasound strain elastography (1)
- unilateral ureteral obstruction (1)
- university teaching (1)
- valence (1)
- valsartan (1)
- value of water (1)
- vancomycin (1)
- variational fracture (1)
- varroa (1)
- vascular endothelial growth factor (1)
- vaskuläre glatte Muskelzelle (1)
- vasopressin (1)
- vector-like quarks (1)
- vena contracta area (1)
- ventromedial prefrontal cortex (1)
- venus (1)
- vertigo (1)
- very high energy (1)
- virus-infection (1)
- viruses (1)
- visual complexity (1)
- visual pigments (1)
- visuomotor coordination (1)
- vitamin metabolism (1)
- volumetric MRI (1)
- volvox carteri (1)
- vorticity preserving (1)
- waggle dance (1)
- water fat separation (1)
- water microbiology (1)
- water oxidation (1)
- wearable (1)
- wearable technology (1)
- web-based apps (1)
- weighted gene co-expression network (1)
- well posedness (1)
- whole exome sequencing (1)
- whole-blood infection assay (1)
- whole-blood model (1)
- wild bees (1)
- wild honey bees (1)
- work behavior (1)
- work capacity evaluation (1)
- working memory (1)
- workplace (1)
- world health organization (1)
- xenobiotic metabolism (1)
- ylides (1)
- zebrafish (1)
- zeitgeber (1)
- zeitliche Organisation (1)
- Ökonometrisches Modell (1)
- Übergangsmetall (1)
- Übergangsmetallkomplexe (1)
- α-emitter (1)
- β-Hydroxybutyrate (1)
- β-cells (1)
- β3 adrenergic receptor (ADRB3) (1)
- β8-β9 loop (1)
- γ-H2AX (1)
Institute
- Physikalisches Institut (83)
- Theodor-Boveri-Institut für Biowissenschaften (79)
- Graduate School of Life Sciences (64)
- Klinik und Poliklinik für Nuklearmedizin (34)
- Institut für Anorganische Chemie (22)
- Institut für Psychologie (20)
- Klinik und Poliklinik für Psychiatrie, Psychosomatik und Psychotherapie (18)
- Medizinische Klinik und Poliklinik II (16)
- Institut für Informatik (15)
- Institut für Mathematik (14)
- Institut für Virologie und Immunbiologie (14)
- Medizinische Klinik und Poliklinik I (14)
- Institut für Pharmazie und Lebensmittelchemie (12)
- Rudolf-Virchow-Zentrum (12)
- Institut für Geographie und Geologie (11)
- Julius-von-Sachs-Institut für Biowissenschaften (11)
- Institut für Organische Chemie (10)
- Institut für Physikalische und Theoretische Chemie (10)
- Institut für Humangenetik (9)
- Institut für Sportwissenschaft (9)
- Klinik und Poliklinik für Anästhesiologie (ab 2004) (9)
- Institut für Anatomie und Zellbiologie (8)
- Institut für Molekulare Infektionsbiologie (8)
- Institut für Pharmakologie und Toxikologie (8)
- Abteilung für Funktionswerkstoffe der Medizin und der Zahnheilkunde (7)
- Institut für Funktionsmaterialien und Biofabrikation (7)
- Kinderklinik und Poliklinik (7)
- Klinik und Poliklinik für Allgemein-, Viszeral-, Gefäß- und Kinderchirurgie (Chirurgische Klinik I) (7)
- Klinik und Poliklinik für Unfall-, Hand-, Plastische und Wiederherstellungschirurgie (Chirurgische Klinik II) (7)
- Lehrstuhl für Tissue Engineering und Regenerative Medizin (7)
- Neurologische Klinik und Poliklinik (7)
- Pathologisches Institut (7)
- Volkswirtschaftliches Institut (7)
- Graduate School of Science and Technology (6)
- Institut für Theoretische Physik und Astrophysik (6)
- Lehrstuhl für Orthopädie (6)
- Fakultät für Biologie (5)
- Institut für Hygiene und Mikrobiologie (5)
- Institut für diagnostische und interventionelle Radiologie (Institut für Röntgendiagnostik) (5)
- Klinik und Poliklinik für Kinder- und Jugendpsychiatrie, Psychosomatik und Psychotherapie (5)
- Lehrstuhl für Molekulare Psychiatrie (5)
- Center for Computational and Theoretical Biology (4)
- Medizinische Fakultät (4)
- Augenklinik und Poliklinik (3)
- Institut Mensch - Computer - Medien (3)
- Institut für Klinische Epidemiologie und Biometrie (3)
- Institut für Politikwissenschaft und Soziologie (3)
- Klinik und Poliklinik für Dermatologie, Venerologie und Allergologie (3)
- Klinik und Poliklinik für Hals-, Nasen- und Ohrenkrankheiten, plastische und ästhetische Operationen (3)
- Physiologisches Institut (3)
- Abteilung für Molekulare Innere Medizin (in der Medizinischen Klinik und Poliklinik II) (2)
- Betriebswirtschaftliches Institut (2)
- Comprehensive Cancer Center Mainfranken (2)
- Deutsches Zentrum für Herzinsuffizienz (DZHI) (2)
- Frauenklinik und Poliklinik (2)
- Institut für Experimentelle Biomedizin (2)
- Institut für Klinische Neurobiologie (2)
- Institut für Klinische Transfusionsmedizin und Hämotherapie (2)
- Institut für Medizinische Strahlenkunde und Zellforschung (2)
- Klinik und Poliklinik für Strahlentherapie (2)
- Fakultät für Chemie und Pharmazie (1)
- Fakultät für Physik und Astronomie (1)
- Graduate School of the Humanities (1)
- Institut für Biblische Theologie (1)
- Institut für Evangelische Theologie und Religionspädagogik (1)
- Institut für Kulturwissenschaften Ost- und Südasiens (1)
- Institut für diagnostische und interventionelle Neuroradiologie (ehem. Abteilung für Neuroradiologie) (1)
- Klinik und Poliklinik für Thorax-, Herz- u. Thorakale Gefäßchirurgie (1)
- Philosophische Fakultät (Histor., philolog., Kultur- und geograph. Wissensch.) (1)
- Poliklinik für Kieferorthopädie (1)
Sonstige beteiligte Institutionen
- Johns Hopkins School of Medicine (15)
- Johns Hopkins University School of Medicine (5)
- Department of Biomedical Imaging, National Cerebral and Cardiovascular Research Center, Suita, Japan (2)
- Division of Medical Technology and Science, Department of Medical Physics and Engineering, Course of Health Science, Osaka University Graduate School of Medicine, Suita Japan (2)
- Institut for Molecular Biology and CMBI, Department of Genomics, Stem Cell Biology and Regenerative Medicine, Leopold-Franzens-University Innsbruck, Innsbruck, Austria (2)
- International Max Planck Research School Molecular Biology, University of Göttingen, Germany (2)
- Johns Hopkins School of Medicine, The Russell H Morgan Department of Radiology and Radiological Science, Baltimore, MD, USA (2)
- ACC GmbH Analytical Clinical Concepts (1)
- BMBF (1)
- Boehringer Ingelheim Pharma GmbH & Co. KG (1)
ResearcherID
- J-8841-2015 (1)
EU-Project number / Contract (GA) number
- 701983 (29)
- 669054 (13)
- 602805 (2)
- 646737 (2)
- 682586 (2)
- 728018 (2)
- 018741 (1)
- 031A408B (1)
- 031A409B (1)
- 037220 (1)
- 115525 (1)
- 242257 (1)
- 260464 (1)
- 294823 (1)
- 311781 (1)
- 336012 (1)
- 602300 (1)
- 613931 (1)
- 614623 (1)
- 643238 (1)
- 647426 (1)
- 658195 (1)
- 667787 (1)
- 678119 (1)
- 686070 (1)
- 703227 (1)
- 716344 (1)
- 721016 (1)
- 823881 (1)
- ESF_14-BM-A55-0005_16 (1)
One of the most significant technological advances in history was driven by the utilization of a new material class: semiconductors.
Its most important application being the transistor, which is indispensable in our everyday life. The technological advance in the semiconductor industry, however, is about to slow down. Making transistors ever smaller to increase the performance and trying to reduce and deal with the dissipative heat will soon reach the limits dictated by quantum mechanics with Moore himself, predicting the death of his famous law in the next decade.
A possible successor for semiconductor transistors is the recently discovered material class of topological insulators. A material which in its bulk is insulating but has topological protected metallic surface states or edge states at its boundary. Their electrical transport characteristics include forbidden backscattering and spin-momentum-locking with the spin of the electron being perpendicular to its momentum. Topological insulators therefore offer an opportunity for high performance devices with low dissipation, and applications in spintronic where data is stored and processed at the same point.
The topological insulator Bi\(_2\)Se\(_3\) and related compounds offer relatively high energy band gaps and a rather simple band structure with a single dirac cone at the gamma point of the Brillouin zone. These characteritics make them ideal candidates to study the topological surface state in electrical transport experiments and explore its physics.
The interaction of synaptic proteins orchestrate the function of one of the most complex organs, the brain. The multitude of molecular elements influencing neurological correlations makes imaging processes complicated since conventional fluorescence microscopy methods are unable to resolve structures beyond the diffraction-limit.
The implementation of super-resolution fluorescence microscopy into the field of neuroscience allows the visualisation of the fine details of neural connectivity. The key element of my thesis is the super-resolution technique dSTORM (direct Stochastic Optical Reconstruction Microscopy) and its optimisation as a multi-colour approach. Capturing more than one target, I aim to unravel the distribution of synaptic proteins with nanometer precision and set them into a structural and quantitative context with one another. Therefore dSTORM specific protocols are optimized to serve the peculiarities of particular neural samples.
In one project the brain derived neurotrophic factor (BDNF) is investigated in primary, hippocampal neurons. With a precision beyond 15 nm, preand post-synaptic sites can be identified by staining the active zone proteins bassoon and homer. As a result, hallmarks of mature synapses can be exhibited. The single molecule sensitivity of dSTORM enables the measurement of endogenous BDNF and locates BDNF granules aligned with glutamatergic pre-synapses. This data proofs that hippocampal neurons are capable of enriching BDNF within the mature glutamatergic pre-synapse, possibly influencing synaptic plasticity.
The distribution of the metabotropic glutamate receptor mGlu4 is investigated in physiological brain slices enabling the analysis of the receptor in its natural environment. With dual-colour dSTORM, the spatial arrangement of the mGlu4 receptor in the pre-synaptic sites of parallel fibres in the molecular layer of the mouse cerebellum is visualized, as well as a four to six-fold increase in the density of the receptor in the active zone compared to the nearby environment. Prior functional measurements show that metabotropic glutamate receptors influence voltage-gated calcium channels and proteins that are involved in synaptic vesicle priming. Corresponding dSTORM data indeed suggests that a subset of the mGlu4 receptor is correlated with the voltage-gated calcium channel Cav2.1 on distances around 60 nm.
These results are based on the improvement of the direct analysis of localisation data. Tools like coordinated based correlation analysis and nearest neighbour analysis of clusters centroids are used complementary to map protein connections of the synapse. Limits and possible improvements of these tools are discussed to foster the quantitative analysis of single molecule localisation microscopy data.
Performing super-resolution microscopy on complex samples like brain slices benefits from a maximised field of view in combination with the visualisation of more than two targets to set the protein of interest in a cellular context. This challenge served as a motivation to establish a workflow for correlated structured illumination microscopy (SIM) and dSTORM. The development of the visualisation software coSIdSTORM promotes the combination of these powerful super-resolution techniques even on separated setups. As an example, synapses in the cerebellum that are affiliated to the parallel fibres and the dendrites of the Purkinje cells are identified by SIM and the protein bassoon of those pre-synapses is visualised threedimensionally with nanoscopic precision by dSTORM.
In this work I placed emphasis on the improvement of multi-colour super-resolution imaging and its analysing tools to enable the investigation of synaptic proteins. The unravelling of the structural arrangement of investigated proteins supports the building of a synapse model and therefore helps to understand the relation between structure and function in neural transmission processes.
Chronic Obstructive Pulmonary Disease (COPD) exacerbations are a considerable reason for increased morbidity and mortality in patients. Infections with influenza virus (H1N1), respiratory syncytial virus (RSV) or nontypeable Haemophilus influenzae (NTHi) are important triggers of exacerbations. To date, no treatments are available which can stop the progression of COPD. Novel approaches are urgently needed. Pre-clinical models of the disease are crucial for the development of novel therapeutic options.
In order to establish pre-clinical models which mimic aspects of human COPD exacerbations, mice were exposed to cigarette smoke (CS) and additionally infected with H1N1, RSV and/or NTHi. Clinically relevant treatments such as the corticosteroids Fluticasone propionate and Dexamethasone, the phosphodiesterase-4 (PDE-4) inhibitor Roflumilast and the long-acting muscarinic receptor antagonist Tiotropium were tested in the established models. Furthermore, a novel treatment approach using antibodies (Abs) directed against IL-1α, IL-1β or IL-1R1 was examined in the established CS/H1N1 model. Levels of IFN-γ, IL-1β, IL-2, IL-6, KC, TNF-α, RANTES, IL-17, MCP-1, MIP 1α and MIP-1β were measured in lung homogenate. Numbers of total cells, neutrophils and macrophages were assessed in bronchoalveolar lavage (BAL) fluid. Hematoxylin- and eosin- (H&E-) stained lung slices were analyzed to detect pathological changes. Quantitative polymerase-chain-reaction (qPCR) was used to investigate gene expression of ICAM-1 and MUC5 A/C. The viral/bacterial load was investigated in lung homogenate or BAL fluid. In addition to the in vivo studies, the effects of the above mentioned treatments were investigated in vitro in H1N1, RSV or NTHi-infected (primary) human bronchial epithelial cells using submerged or air-liquid-interface (ALI) cell culture systems.
Four pre-clinical models (CS/H1N1, CS/RSV, CS/NTHi, CS/H1N1/NTHi) were established depicting clinically relevant aspects of COPD exacerbations such as increased inflammatory cells and cytokines in the airways and impaired lung function.
In the CS/H1N1 model, Tiotropium improved lung function and was superior in reducing inflammation in comparison to Fluticasone or Roflumilast. Moreover, Fluticasone increased the loss of body-weight, levels of IL-6, KC and TNF-α and worsened lung function. In CS/RSV-exposed mice Tiotropium but not Fluticasone or Roflumilast treatment reduced neutrophil numbers and IL-6 and TNF α levels in the lung. The viral load of H1N1 and RSV was significantly elevated in CS/virus-exposed mice and NCI-H292 cells after Fluticasone and Dexamethasone treatment. The results from these studies demonstrate that Tiotropium has anti-inflammatory effects on CS/virus-induced inflammation and might help to explain the observed reduction of exacerbation rates in Tiotropium-treated COPD patients. Furthermore, the findings from this work indicate that treatment with Fluticasone or Dexamethasone might not be beneficial to reduce inflammation in the airways of COPD patients and supports clinical studies that link treatment with corticosteroids to an increased risk for pneumonia.
Testing of anti-IL-1α, anti-IL-1β or anti-IL-1R1 Abs in the CS/H1N1 model suggests that, in line with clinical data, antagonization of IL-1β is not sufficient to reduce pulmonary inflammation and indicates a predominant role of IL-1α in CS/virus-induced airway inflammation. In line with the in vivo findings, anti-IL-1α but not anti-IL-1β Abs reduced levels of TNF-α and IL-6 in H1N1-infected primary human bronchial epithelial ALI cell culture. Blocking the IL-1R1 provided significant inhibitory effects on inflammatory cells in vivo but was inferior compared to inhibiting both its soluble ligands IL-1α and IL-1β. Concomitant usage of Abs against IL-1α/IL-1β revealed strong effects and reduced total cells, neutrophils and macrophages. Additionally, levels of KC, IL-6, TNF-α, MCP-1, MIP-1α and MIP-1β were significantly reduced and ICAM-1 mRNA expression was attenuated. These results suggest that combined inhibition of IL-1α/IL-1β might be beneficial to reduce inflammation and exacerbations in COPD patients. Moreover, combined targeting of both IL-1α/IL-1β might be more efficient compared to inhibition of the IL-1R1.
As in the CS/virus models, corticosteroid treatment failed to reduce inflammatory cells in the CS/NTHi and CS/H1N1/NTHi models, increased the loss of body-weight and the bacterial load. Furthermore, Roflumilast administration had no significant effects on cell counts or cytokines. However, it improved compliance in the CS/NTHi model. Treatment with Azithromycin reduced the bacterial load in the CS/NTHi model and reduced numbers of total cells, neutrophils, macrophages and levels of KC and TNF-α in the CS/H1N1/NTHi model.
In conclusion, the established CS/H1N1, CS/RSV, CS/NTHi, CS/H1N1/NTHi models depict clinically relevant aspects of human COPD exacerbations in mice and provide the opportunity to investigate underlying disease mechanisms and to test novel therapies.
Imagine a technology that automatically creates a full 3D thermal model of an environment and detects temperature peaks in it. For better orientation in the model it is enhanced with color information. The current state of the art for analyzing temperature related issues is thermal imaging. It is relevant for energy efficiency but also for securing important infrastructure such as power supplies and temperature regulation systems. Monitoring and analysis of the data for a large building is tedious as stable conditions need to be guaranteed for several hours and detailed notes about the pose and the environment conditions for each image must be taken. For some applications repeated measurements are necessary to monitor changes over time. The analysis of the scene is only possible through expertise and experience.
This thesis proposes a robotic system that creates a full 3D model of the environment with color and thermal information by combining thermal imaging with the technology of terrestrial laser scanning. The addition of a color camera facilitates the interpretation of the data and allows for other application areas. The data from all sensors collected at different positions is joined in one common reference frame using calibration and scan matching. The first part of the thesis deals with 3D point cloud processing with the emphasis on accessing point cloud data efficiently, detecting planar structures in the data and registering multiple point clouds into one common coordinate system. The second part covers the autonomous exploration and data acquisition with a mobile robot with the objective to minimize the unseen area in 3D space. Furthermore, the combination of different modalities, color images, thermal images and point cloud data through calibration is elaborated. The last part presents applications for the the collected data. Among these are methods to detect the structure of building interiors for reconstruction purposes and subsequent detection and classification of windows. A system to project the gathered thermal information back into the scene is presented as well as methods to improve the color information and to join separately acquired point clouds and photo series.
A full multi-modal 3D model contains all the relevant geometric information about the recorded scene and enables an expert to fully analyze it off-site. The technology clears the path for automatically detecting points of interest thereby helping the expert to analyze the heat flow as well as localize and identify heat leaks. The concept is modular and neither limited to achieving energy efficiency nor restricted to the use in combination with a mobile platform. It also finds its application in fields such as archaeology and geology and can be extended by further sensors.
Genetic foundation of unrivaled survival strategies - Of water bears and carnivorous plants -
(2018)
All living organisms leverage mechanisms and response systems to optimize reproduction, defense, survival, and competitiveness within their natural habitat. Evolutionary theories such as the universal adaptive strategy theory (UAST) developed by John Philip Grime (1979) attempt to describe how these systems are limited by the trade-off between growth, maintenance and regeneration; known as the universal three-way trade-off. Grime introduced three adaptive strategies that enable organisms to coop with either high or low intensities of stress (e.g., nutrient deficiency) and environmental disturbance (e.g., seasons). The competitor is able to outcompete other organisms by efficiently tapping available resources in environments of low intensity stress and disturbance (e.g., rapid growers). A ruderal specism is able to rapidly complete the life cycle especially during high intensity disturbance and low intensity stress (e.g., annual colonizers). The stress tolerator is able to respond to high intensity stress with physiological variability but is limited to low intensity disturbance environments. Carnivorous plants like D. muscipula and tardigrades like M. tardigradum are two extreme examples for such stress tolerators. D. muscipula traps insects in its native habitat (green swamps in North and South Carolina) with specialized leaves and thereby is able to tolerate nutrient deficient soils. M. tardigradum on the other side, is able to escape desiccation of its terrestrial habitat like mosses and lichens which are usually covered by a water film but regularly fall completely dry. The stress tolerance of the two species is the central study object of this thesis. In both cases, high througput sequencing data and methods were used to test for transcriptomic (D. muscipula) or genomic adaptations (M. tardigradum) which underly the stress tolerance. A new hardware resource including computing cluster and high availability storage system was implemented in the first months of the thesis work to effectively analyze the vast amounts of data generated for both projects. Side-by-side, the data management resource TBro [14] was established together with students to intuitively approach complex biological questions and enhance collaboration between researchers of several different disciplines. Thereafter, the unique trapping abilities of D. muscipula were studied using a whole transcriptome approach. Prey-dependent changes of the transcriptional landscape as well as individual tissue-specific aspects of the whole plant were studied. The analysis revealed that non-stimulated traps of D. muscipula exhibit the expected hallmarks of any typical leaf but operates evolutionary conserved stress-related pathways including defense-associated responses when digesting prey. An integrative approach, combining proteome and transcriptome data further enabled the detailed description of the digestive cocktail and the potential nutrient uptake machinery of the plant. The published work [25] as well as a accompanying video material (https://www.eurekalert.org/pub_releases/ 2016-05/cshl-fgr042816.php; Video credit: Sönke Scherzer) gained global press coverage and successfully underlined the advantages of D. muscipula as experimental system to understand the carnivorous syndrome. The analysis of the peculiar stress tolerance of M. tardigradum during cryptobiosis was carried out using a genomic approach. First, the genome size of M. tardigradum was estimated, the genome sequenced, assembled and annotated. The first draft of M. tardigradum and the workflow used to established its genome draft helped scrutinizing the first ever released tardigrade genome (Hypsibius dujardini) and demonstrated how (bacterial) contamination can influence whole genome analysis efforts [27]. Finally, the
M. tardigradum genome was compared to two other tardigrades and all species present in the current release of the Ensembl Metazoa database. The analysis revealed that tardigrade genomes are not that different from those of other Ecdysozoa. The availability of the three genomes allowed the delineation of their phylogenetic position within the Ecdysozoa and placed them as sister taxa to the nematodes. Thereby, the comparative analysis helped to identify evolutionary trends within this metazoan lineage. Surprisingly, the analysis did not reveal general mechanisms (shared by all available tardigrade genomes) behind the arguably most peculiar feature of tardigrades; their enormous stress tolerance. The lack of molecular evidence for individual tardigrade species (e.g., gene expression data for M. tardigradum) and the non-existence of a universal experimental framework which enables hypothesis testing withing the whole phylum Tardigrada, made it nearly impossible to link footprints of genomic adaptations to the unusual physiological capabilities. Nevertheless, the (comparative) genomic framework established during this project will help to understand how evolution tinkered, rewired and modified existing molecular systems to shape the remarkable phenotypic features of tardigrades.
The goal of this work is to improve the understanding of adsorption-induced deformation in nanoporous (and in particular microporous) materials in order to explore its potential for material characterization and provide guidelines for related technical applications such as adsorption-driven actuation. For this purpose this work combines in-situ dilatometry measurements with in-depth modeling of the obtained adsorption-induced strains. A major advantage with respect to previous studies is the combination of the dilatometric setup and a commercial sorption instrument resulting in high quality adsorption and strain isotherms. The considered model materials are (activated and thermally annealed) carbon xerogels, a sintered silica aerogel, a sintered hierarchical structured porous silica and binderless zeolites of type LTA and FAU; this selection covers micro-, meso- and macroporous as well as ordered and disordered model materials.
All sample materials were characterized by scanning electron microscopy, gas adsorption and sound velocity measurements. In-situ dilatometry measurements on mesoporous model materials were performed for the adsorption of N2 at 77 K, while microporous model materials were also investigated for CO2 adsorption at 273 K, Ar adsorption at 77 K and H2O adsorption at 298 K. Within this work the available in-situ dilatometry setup was revised to improve resolution and reproducibility of measurements of small strains at low relative pressures, which are of particular relevance for microporous materials.
The obtained experimental adsorption and strain isotherms of the hierarchical structured porous silica and a micro-macroporous carbon xerogel were quantitatively analyzed based on the adsorption stress model; this approach, originally proposed by Ravikovitch and Neimark, was extended for anisotropic pore geometries within this work. While the adsorption in silica mesopores could be well described by the classical and analytical theory of Derjaguin, Broekhoff and de Boer, the adsorption in carbon micropores required for comprehensive nonlocal density functional theory calculations. To connect adsorption-induced stresses and strains, furthermore mechanical models for the respective model materials were derived. The resulting theoretical framework of adsorption, adsorption stress and mechanical model was applied to the experimental data yielding structural and mechanical information about the model materials investigated, i.e., pore size or pore size distribution, respectively, and mechanical moduli of the porous matrix and the nonporous solid skeleton. The derived structural and mechanical properties of the model materials were found to be consistent with independent measurements and/or literature values. Noteworthy, the proposed extension of the adsorption stress model proved to be crucial for the correct description of the experimental data.
Furthermore, it could be shown that the adsorption-induced deformation of disordered mesoporous aero-/xerogel structures follows qualitatively the same mechanisms obtained for the ordered hierarchical structured porous silica. However, respective quantitative modeling proved to be challenging due to the ill-shaped pore geometry of aero-/xerogels; good agreement between model and experiment could only be achieved for the filled pore regime of the adsorption isotherm and the relative pressure range of monolayer formation. In the intermediate regime of multilayer formation a more complex model than the one proposed here is required to correctly describe stress related to the curved adsorbate-adsorptive interface. Notably, for micro-mesoporous carbon xerogels it could be shown that micro- and mesopore related strain mechanisms superimpose one another.
The strain isotherms of the zeolites were only qualitatively evaluated. The result for the FAU type zeolite is in good agreement with other experiments reported in literature and the theoretical understanding derived from the adsorption stress model. On the contrary, the strain isotherm of the LTA type zeolite is rather exceptional as it shows monotonic expansion over the whole relative pressure range. Qualitatively this type of strain isotherm can also be explained by the adsorption stress model, but a respective quantitative analysis is beyond the scope of this work.
In summary, the analysis of the model materials' adsorption-induced strains proved to be a suitable tool to obtain information on their structural and mechanical properties including the stiffness of the nonporous solid skeleton. Investigations on the carbon xerogels modified by activation and thermal annealing revealed that adsorption-induced deformation is particularly suited to analyze even small changes of carbon micropore structures.
In this dissertation the electronic and high-energy optical properties of thin nanoscale
films of the magnetic topological insulator (MTI) (V,Cr)y(BixSb1-x)2-yTe3 are studied
by means of X-ray photoelectron spectroscopy (XPS) and electron energy-loss
spectroscopy (EELS). Magnetic topological insulators are presently of broad interest
as the combination of ferromagnetism and spin-orbit coupling in these materials
leads to a new topological phase, the quantum anomalous Hall state (QAHS), with
dissipation less conduction channels. Determining and controlling the physical
properties of these complex materials is therefore desirable for a fundamental understanding
of the QAHS and for their possible application in spintronics. EELS can
directly probe the electron energy-loss function of a material from which one can
obtain the complex dynamic dielectric function by means of the Kramers-Kronig
transformation and the Drude-Lindhard model of plasmon oscillations.
The XPS core-level spectra in (V,Cr)y(BixSb1-x)2-yTe3 are analyzed in detail with
regards to inelastic background contributions. It is shown that the spectra can be
accurately described based on the electron energy-loss function obtained from an
independent EELS measurement. This allows for a comprehensive and quantitative
analysis of the XPS data, which will facilitate future core-level spectroscopy studies
in this class of topological materials. From the EELS data, furthermore, the bulk and
surface optical properties were estimated, and compared to ab initio calculations
based on density functional theory (DFT) performed in the GW approximation
for Sb2Te3. The experimental results show a good agreement with the calculated
complex dielectric function and the calculated energy-loss function. The positions of
the main plasmon modes reported here are expected to be generally similar in other
materials in this class of nanoscale TI films. Hence, the present work introduces
EELS as a powerful method to access the high-energy optical properties of TI
thin films. Based on the presented results it will be interesting to explore more
systematically the effects of stoichiometry, magnetic doping, film thickness and
surface morphology on the electron-loss function, potentially leading to a better
understanding of the complex interplay of structural, electronic, magnetic and
optical properties in MTI nanostructures.
The self-stabilizing, tetrameric cyanoborylene [(cAAC)B(CN)]4 (I, cAAC = 1-(2,6-diisopropylphenyl)-3,3,5,5-tetramethylpyrrolidin-2-ylidene) and its diborene relative, [(cAAC)(CN)B=B(CN)(cAAC)] (II), both react with disulfides and diselenides to yield the corresponding cAAC-supported cyanoboron bis(chalcogenides). Furthermore, reactions of I or II with elemental sulfur and selenium in various stoichiometries provided access to a variety of cAAC- stabilized cyanoboron-chalcogen heterocycles, including a unique dithiaborirane, a diboraselenirane, 1,3-dichalcogena-2,4-diboretanes, 1,3,4-trichalcogena- 2,5-diborolanes and a rare six-membered 1,2,4,5-tetrathia-3,6-diborinane. Stepwise addition reactions and solution stability studies provided insights into the mechanism of these reactions and the subtle differences in reactivity observed between I and II.
Coherent Multidimensional Spectroscopy in Molecular Beams and Liquids Using Incoherent Observables
(2018)
The aim of the present work was to implement an experimental approach that enables coherent two-dimensional (2D) electronic spectroscopy of samples in various states of matter. For samples in the liquid phase, a setup was realized that utilizes the sample fluorescence for the acquisition of 2D spectra. Whereas the liquid-phase approach has been established before, coherent 2D spectroscopy on gaseous samples in a molecular beam as developed in this work is in fact a new method. It employs for the first time cations in a time-of-flight mass spectrometer for signal detection and was used to obtain the first ion-selective 2D spectra of a molecular-beam sample. Additionally, a new acquisition concept was developed in this thesis that significantly decreases measurement times in 2D spectroscopy using optimized sparse sampling and a compressed-sensing reconstruction algorithm.
Characteristic for the variant of 2D spectroscopy presented in this work is the usage of a phase-coherent sequence of four laser pulses in a fully collinear geometry for sample excitation. The pulse sequence was generated by a custom-designed pulse shaper that is capable of rapid scanning by changing the pulse parameters such as time delays and phases with the repetition rate of the laser. The sample's response was detected by monitoring incoherent observables that arise from the final-state population, for instance fluorescence or cations. Phase cycling, i.e., signal acquisition with different combinations of the relative phases of the excitation pulses, was applied to extract nonlinear signal contributions from the full signal during data analysis.
Liquid-phase 2D fluorescence spectroscopy was established with the laser dye cresyl violet as a sample molecule, confirming coherent oscillations previously observed in literature that are originating from vibronic coherences in specific regions of the 2D spectrum.
The data set of this experiment was used subsequently to introduce optimized sparse sampling in 2D spectroscopy. An optimization algorithm was implemented in order to find the best sampling pattern while taking only one quarter of the regular time-domain sampling points, thereby reducing the acquisition time by a factor of four. Signal recovery was based on a new and compact representation of 2D spectra using the von Neumann basis, which required about six times less coefficients than the Fourier basis to retain the relevant information. Successful reconstruction was shown by recovering the coherent oscillations in cresyl violet from a reduced data set.
Finally, molecular-beam coherent 2D spectroscopy was introduced with an investigation of ionization pathways in highly-excited nitrogen dioxide, revealing transitions to discrete auto-ionizing states as the dominant contribution to the ion signal. Furthermore, the advantage of the time-of-flight approach to obtain reactant and product 2D spectra simultaneously enabled the observation of distinct differences in the multiphoton-ionization response functions of the nitrogen dioxide cation and the nitrogen oxide ionic fragment.
The developed experimental techniques of this work will facilitate fast acquisition of 2D spectra for samples in various states of matter and permit reliable direct comparison of results. Therefore, they pave the way to study the properties of quantum coherences during photophysical processes or photochemical reactions in different environments.
Staphylococcus aureus asymptomatically colonises one third of the healthy human population, finding its niche in the nose and on skin. Apart from being a commensal, it is also an important opportunistic human pathogen capable of destructing tissue, invading host cells and killing them from within. This eventually contributes to severe hospital- and community-acquired infections. Methicillin-resistant Staphylococcus aureus (MRSA), resistant to commonly used antibiotics are protected when residing within the host cell.
This doctoral thesis is focused on the investigation of staphylococcal factors governing intracellular virulence and subsequent host cell death. To initiate an unbiased approach to conduct this study, complex S. aureus mutant pools were generated using transposon insertional mutagenesis. Genome-wide infection screens were performed using these S. aureus transposon mutant pools in vitro and in vivo, followed by analysis using Transposon insertion site deep sequencing (Tn-seq) technology.
Amongst several other factors, this study identified a novel regulatory system in S. aureus that controls pathogen-induced host cytotoxicity and intra-host survival. The primary components of this system are an AraC-family transcription regulator called Repressor of surface proteins (Rsp) and a virulence associated non-coding RNA, SSR42. Mutants within rsp exhibit enhanced intra-host survival in human epithelial cells and delayed host cytotoxicity. Global gene-expression profiling by RNA-seq demonstrated that Rsp controls the expression of SSR42, several cytotoxins and other bacterial factors directed against the host immune system. Rsp enhances S. aureus toxin response when triggered by hydrogen peroxide, an antimicrobial substance employed by neutrophils to destroy pathogens. Absence of rsp reduces S. aureus-induced neutrophil damage and early lethality during mouse pneumonia, but still permits blood stream infection. Intriguingly, S. aureus lacking rsp exhibited enhanced survival in human macrophages, which hints towards a Trojan horse-like phenomenon and could facilitate dissemination within the host.
Hence, Rsp emerged as a global regulator of bacterial virulence, which has an impact on disease progression with prolonged intra-cellular survival, delayed-lethality but allows disseminated manifestation of disease. Moreover, this study exemplifies the use of genome-wide approaches as useful resources for identifying bacterial factors and deduction of its pathogenesis.