Refine
Has Fulltext
- yes (310)
Is part of the Bibliography
- yes (310)
Year of publication
Document Type
- Journal article (310) (remove)
Keywords
- Organische Chemie (122)
- Chemie (9)
- 1 (8)
- fluorescence (8)
- water oxidation (8)
- 3 (7)
- polycyclic aromatic hydrocarbons (7)
- self-assembly (7)
- RNA (6)
- organic chemistry (6)
- photocatalysis (6)
- Diels-Alder reactions (5)
- SARS-CoV-2 (5)
- dyes (5)
- luminescence (5)
- chemistry (4)
- circular dichroism (4)
- in vitro selection (4)
- perylene bisimide (4)
- sphingolipids (4)
- structure elucidation (4)
- supramolecular chemistry (4)
- 4-0xadiazin-6-ones (3)
- absolute configuration (3)
- aggregation (3)
- aromaticity (3)
- artificial photosynthesis (3)
- boranes (3)
- catalysis (3)
- cell imaging (3)
- ceramide (3)
- ceramides (3)
- chirality (3)
- dyes/pigments (3)
- exciton coupling (3)
- homogeneous catalysis (3)
- kinetics (3)
- liquid crystals (3)
- macrocycles (3)
- molecular docking (3)
- organic photodiodes (3)
- photoinduced electron transfer (3)
- 2 (2)
- 4-0xadiazine-2-carboxylate (2)
- 6 (2)
- Anorganische Chemie (2)
- Carbocations (2)
- Chili RNA Aptamer (2)
- Deoxyribozymes (2)
- Design (2)
- Dyes (2)
- Enol Iactones (2)
- Epitranscriptomics (2)
- Fluorescence (2)
- G-quadruplexes (2)
- Holothuria spinifera (2)
- J‐aggregates (2)
- Ketenes (2)
- LC-HRESIMS (2)
- RNA modification (2)
- RNA-dependent RNA polymerase (2)
- Ruthenium complexes (2)
- UV/Vis spectroscopy (2)
- absorption (2)
- acid sphingomyelinase (2)
- annulation (2)
- azulene (2)
- boronate esters (2)
- cage compounds (2)
- cerebrosides (2)
- chirality transfer (2)
- click chemistry (2)
- corannulene (2)
- crystal engineering (2)
- cyclophanes (2)
- cytotoxic activity (2)
- cytotoxicity (2)
- density functional calculations (2)
- dynamic covalent chemistry (2)
- electrocatalysis (2)
- energy transfer (2)
- fullerenes (2)
- helicenes (2)
- heterogeneous catalysis (2)
- hexahydro- (2)
- homogenous catalysis (2)
- hydrogen bonding (2)
- lysosome (2)
- marine natural product (2)
- merocyanines (2)
- methyl 6-oxo-5-phenyl- (2)
- nanographene (2)
- optical spectroscopy (2)
- organic semiconductors (2)
- organic solar cells (2)
- pentacene (2)
- perylene bisimides (2)
- phosphorescence (2)
- polymerization (2)
- polymers (2)
- preparation (2)
- renewable fuels (2)
- ruthenium (2)
- ruthenium bda complexes (2)
- ruthenium complexes (2)
- singlet oxygen (2)
- site-specific RNA cleavage (2)
- solid-state emitters (2)
- solvent effects (2)
- spectroscopy (2)
- squaraine dyes (2)
- stereochemistry (2)
- streptomyces (2)
- thermodynamics (2)
- two-photon absorption (2)
- two-photon excited fluorescence (2)
- water (2)
- water splitting (2)
- y-oxo- (2)
- 0]hexane (1)
- 1' -c]naphthalene (1)
- 1-aryl- (1)
- 1-dibromo-1a (1)
- 10 (1)
- 11-dihydro- / 1-Pyrazoline (1)
- 2-Bismethylenecyclobutanes (1)
- 2-Bismethylenecyclohexane (1)
- 2-Cyclopentanedione derivatives (1)
- 2-Norcaranols (1)
- 2-photon absorption (1)
- 2-α:2' (1)
- 3-Azabicyclo{3 (1)
- 3-Methenonaphthalenes (1)
- 3-aryl- (1)
- 3-cyclohexadiene (1)
- 3-n-butyl-N-phenyl- (1)
- 4 (1)
- 4-Pentadienylamine (1)
- 4-tetrahydro- (1)
- 4</sup>.0<sup>3 (1)
- 4]0xadiazino[4 (1)
- 4]non-7-en-6-ylpotassium (1)
- 4a (1)
- 5 (1)
- 5-b]isoquinolin-1-one derivatives (1)
- 5-dinitrobenzoates (1)
- 5</sup>]beptanes (1)
- 5H-Dibenzo[a (1)
- 5]cyclohepta[ 1 (1)
- 6-Norpinanols (1)
- 6-Norpinyl 3 (1)
- 6-Thiatricyclo[3.2.1.o 2.7 ]oct-3-ene 6 (1)
- 6-aryl- (1)
- 6-dibromo-3-phenyl- (1)
- 6-dioxide (1)
- 6-phenyl (1)
- 6H-1 (1)
- 6a-Tetrahydro-2H-cyclobuta[b]pyrans (1)
- 7 (1)
- 7-Norcaranylidene carbenoid (1)
- 7-dibromo (1)
- 7</sup>]heptane derivatives (1)
- 7b-tetrahydro- (1)
- 8 (1)
- 8-Tetrahydro-3H-2-benzopyrans (1)
- 8a-Tetrahydro-2H-1-benzopyran (1)
- ADME analysis (1)
- AIE (1)
- API (1)
- Adipic acid (1)
- Aldehyde Bioconjugation (1)
- Alkyltransferase Ribozyme SAMURI (1)
- Allenes (1)
- Alzheimer′s disease (1)
- Amplification (1)
- Anchimeric assistance in solvolysis (1)
- Ancistrocladus ealaensis (1)
- Ancistrocladus likoko (1)
- Antiviral nucleoside analogues (1)
- Apoptosis (1)
- Aromatic-hydrocarbon (1)
- Aspergillus niger (1)
- Atomic and molecular interactions with photons (1)
- Auflösungsraten (1)
- BMP-2 (1)
- BMP-2 delivery (1)
- Bacillus megaterium (1)
- Baltic Sea (1)
- Barbaralane derivatives (1)
- Benzocycloheptene derivatives (1)
- Bicyclo[1.1.0]butane derivatives (1)
- Bicyclo[1.1.0]butanes (1)
- Bicyclo[1.1.0]butylcarbinyl sulfonates (1)
- Bicyclo[2.1.l]hexan-5-one (1)
- Bicyclo[3.2.0.0<sup>2 (1)
- Bicyclo[3.2.0]hept-6-ene derivatives (1)
- Bicyclo[3.2.1]oct-3-en-2-yl anions (1)
- Biochemistry (1)
- Biocompatibility (1)
- Biodegradable polymer scaffolds (1)
- Bioorthogonal Tag (1)
- Bisbenzo[ 4 (1)
- Bone morphogenetic protein-2 (1)
- Bone tissue engineering (1)
- Butadien (1)
- C-13 NMR (1)
- C-C coupling (1)
- CCL2 (MCP-1) (1)
- CD4+ T cells (1)
- CD8+ T cells (1)
- CXCL8 (IL-8) (1)
- Caco-2 (1)
- Carbene insertion (1)
- Carbon (1)
- Ceramide (1)
- Chemical modification (1)
- Chiralität (1)
- Chromophore Assembly (1)
- Chromophores (1)
- Co-Crystal Structures of Chili RNA (1)
- Conjugated polymers (1)
- Corannulene (1)
- Cryoelectron Microscopy (1)
- Cryoelectron microscopy (1)
- Cycloadditions (1)
- Cycloallene dimerization (1)
- Cyclobuta[c}pyridines (1)
- Cyclobutylcarbinyl sulfonates (1)
- Cyclohept-3-en-1-ols (1)
- Cyclopropanetetracarbonitrile derivatives (1)
- DNA (1)
- DNA catalysis (1)
- DNA/RNA binding (1)
- DNA/RNA sensors (1)
- DNS-Schädigung (1)
- Deoxyribozyme (1)
- Dictyota (1)
- Dictyotaceae (1)
- Dimers (1)
- Donor−acceptor dyads (1)
- EPR (1)
- Effectors in plant pathology (1)
- Electron (1)
- Electron demand in ditosylates (1)
- Electron transfer (1)
- Emission (1)
- Energy transfer (1)
- Enzymes (1)
- Eriodictyon californicum (1)
- FT-IR spectroscopy (1)
- Festkörper-NMR (1)
- Fiels-effect transistors (1)
- Fluorescence and Crosslinking (1)
- Fluoreszenz (1)
- Fluoreszenzresonanz-Energietransfer (1)
- Fluorogenic RNA Aptamers (1)
- Functional nucleic acids (1)
- Functionalization (1)
- Fungal host response (1)
- Garcinia biflavonoids (1)
- Gibbs activation energy (1)
- Glycosyltransferase (1)
- Golgi (1)
- Graphene nanoribbons (1)
- Growth; BMP-2 (1)
- H2A histone family member X (H2AX) (1)
- HIV (1)
- HRMS (1)
- Halonium ions (1)
- Helicen (1)
- High efficiency (1)
- High performance (1)
- Homo Diels-Alder reactions (1)
- Homoaromaticity in carbanions (1)
- Homobenzvalene (1)
- Hyperfine coupling constants (1)
- In-vitro (1)
- Indirect and direct contributions to A<sub>iso</sub> (1)
- Influence of excitation classes (1)
- Intensity (1)
- Isomorphe Nukleobasen-Analoga (1)
- Isoquinolines (1)
- J-aggregate behavior (1)
- J-aggregates (1)
- Jurkat cells (1)
- K-region (1)
- K2–K model (1)
- Koordinationsisomerie (1)
- Lactone conformations (1)
- Lectins (1)
- Light-emitting diodes (1)
- Line-shape analysis (1)
- Lippert–Mataga plot (1)
- Liquid-crystalline (1)
- Long-range coupling constants (1)
- MAS (1)
- METTL8 (1)
- Mandibular continuity defects (1)
- Marcus inverted region (1)
- Marrow stromal cells (1)
- Merocyanine (1)
- Mesenchymal transition (1)
- Microenvironment (1)
- Migratory aptitudes in carbocations (1)
- Mitochondrial Matrix Protein (1)
- Mizellen (1)
- Modified Nucleotides in tRNAs (1)
- Molecular mechanism (1)
- Molecular-dynamics (1)
- Molecules (1)
- Molnupiravir (1)
- Molnupiravir-Induced RNA Mutagenesis Mechanism (1)
- Multibranched structures (1)
- N-oleoyl serinol (1)
- NDI-H (1)
- NIR OLED (1)
- NMR spectroscopy (1)
- Nahordnung (1)
- Naphthylisoindolinone alkaloids (1)
- Neighbouring group participation (1)
- Neisseria (1)
- Nonbonded Interactions (1)
- Norcaranes (1)
- Norpinanes (1)
- Nucleic Acids (1)
- Nucleobase Analogue (1)
- OEG chains (1)
- Octavalen (1)
- Oligofructoside (1)
- One-photon (1)
- Optical Spectroscopy (1)
- Optical properties (1)
- Optical spectroscopy (1)
- Oral squamous cell carcinoma (1)
- Organelles (1)
- Organobor (1)
- PBI cyclophane (1)
- PI stacking (1)
- Pathway (1)
- Perovskite (1)
- Phaeophyceae (1)
- Photochemistry (1)
- Photoelektron (1)
- Photoresponsives Verhalten (1)
- Polymer-drug interaction (1)
- Polymere (1)
- Polymers (1)
- Potential-energy curves (1)
- QM/MM (1)
- RNA Enzymes (1)
- RNA Labelling (1)
- RNA Methyltransferase (1)
- RNA Modification (1)
- RNA aptamers (1)
- RNA labeling (1)
- RNA ligation (1)
- RNA splicing (1)
- RNA-Aptamere (1)
- RNA-Dependent RNA Polymerase (1)
- RU-(II) complexes (1)
- Radical-ion pair (1)
- Rearrangement of carbocations (1)
- Remdesivir (1)
- Ribozyme (1)
- Ru(II)–Fe(II)–Ru(II) complex (1)
- SARS-CoV-2 polymerase (1)
- SARS-CoV2 Replication Impairment (1)
- SacB (1)
- Scleractinia (1)
- Screening (1)
- Selbstassemblierung (1)
- Simulations (1)
- Sinus floor augmentation (1)
- Site-Specific RNA Cleavage (1)
- Site-specific RNA labelling (1)
- Solution-state NMR (1)
- Spin density (1)
- Spirotetracyclo[4.1.0.0<sup>2 (1)
- Squamous-cell carcinoma (1)
- Sracking (1)
- Staphylococcus aureus (1)
- State (1)
- Stereochemistry (1)
- Stokes-Verschiebung (1)
- Stokes-shifted fluorescence emission (1)
- Streptomyces axinellae (1)
- Structural Biology (1)
- Structure elucidation (1)
- Struktursonden (1)
- Stylissa carteri (1)
- Suc1 (1)
- Supramolecular Element (1)
- Supramolekulare Polymere (1)
- Suzuki coupling (1)
- Synthetic Functional RNAs (1)
- Systems (1)
- TERRA RNA (1)
- Tetrakis(arylmethylene)ethane diradical (1)
- Thalassodendron ciliatum (1)
- Tricyclo[3.3.1.0 2 (1)
- Tricyclo[4.1.0.0<sup>2.7</sup>]heptanes (1)
- Tumorigenicity (1)
- Urazoles (1)
- Vibronic contributions (1)
- X-ray Crystallography (1)
- X-ray crystallography (1)
- X-ray diffraction (1)
- XNA (1)
- XRPD (1)
- Zirkulardichroismus (1)
- [1 (1)
- [2 + 2]- and [4 + 2]- (1)
- [n]helicenes (1)
- \(\alpha\)-phase (1)
- \(\beta\)-phase (1)
- \(^{1}\)H-\(^{13}\)C HETCOR (1)
- abietane (1)
- activating transcription factor 4 (ATF4) (1)
- adsorption (1)
- aelf-assembly (1)
- alkaloids (1)
- alpha (1)
- amphiphilic dyes (1)
- amplification (1)
- ancistrocladinium A (1)
- annihilation (1)
- anti-cancer-agent (1)
- anti-depressant drug (1)
- anti-trypanosomal (1)
- antibacterial activity (1)
- antidepressants (1)
- antimicrobials (1)
- aqua material (1)
- aqueous medium (1)
- arene-fluoroarene (1)
- arenes (1)
- artificial base pair (1)
- association (1)
- ataxia teleagiectasia mutated (ATM) (1)
- azaborole (1)
- azaphilone (1)
- azido-ceramides (1)
- bacterial infection (1)
- bartalinia robillardoides (1)
- bicyclic (1)
- biflavanoids (1)
- bile salt (1)
- bioactive compound (1)
- bioactivities (1)
- biocompatibility (1)
- biological techniques (1)
- biomass (1)
- bioorthogonal SAM analogue ProSeDMA (1)
- bioorthogonal metabolic glycoengineering; click chemistry; sialic acid (1)
- biophysical investigation (1)
- biosynthesis (1)
- bis-terpyridyl ligands (1)
- boric acid (1)
- boron (1)
- boronateesters (1)
- borylation (1)
- brown seaweeds (1)
- bulk-heterojunction solar cells (1)
- carbon (1)
- carrier transport (1)
- cascade reactions (1)
- catalyst (1)
- catalyst synthesis (1)
- catalysts (1)
- catalytic (1)
- catalytic activity (1)
- catalytic mechanisms (1)
- cell membrane model (1)
- cellular stress response (1)
- ceramidase (1)
- ceramide analogs (1)
- cerebroside (1)
- ceriops decandra (1)
- charge transport (1)
- charge transport; hydrogen bonding; oligothiophene; organogel; self-assembly (1)
- chiral resolution (1)
- circular polarized luminescence (1)
- circularly polarized luminescence (1)
- classical and nonclassical (1)
- co-aggregation (1)
- cocrystallization (1)
- colloid (1)
- columnar phases (1)
- complexity (1)
- configurational stability (1)
- conformation (1)
- conjugated molecule (1)
- cooperative self-assembly (1)
- coordination chemistry (1)
- coordination oligomer (1)
- coordination oligomers (1)
- covalent organic framework (1)
- covalent organic frameworks (1)
- cristal engeneering (1)
- crystalline (1)
- crystals (1)
- curcumin (1)
- curvature (1)
- curved π-systems (1)
- cyclic / 1-0xa-2 (1)
- cyclic perylene bisimide (1)
- cyclodehydrogenation (1)
- cylindrical micelles (1)
- cysteine protease (1)
- cytoplasm (1)
- d]cycloheptene (1)
- decandrinin (1)
- deoxyribozymes (1)
- deracemization (1)
- di-\(\pi\)-methane rearrangement (1)
- dibenzosemibullvalenes (1)
- differential scanning calorimetry (1)
- diffusion (1)
- diketopyrrolopyrroles (1)
- dimerization (1)
- dimers (1)
- dinuclear (1)
- dipole-dipole interaction (1)
- discotic liquid crystals (1)
- discovery (1)
- dissolution rates (1)
- disulfide bonds (1)
- docking (1)
- docking studies (1)
- donor-acceptor dyad (1)
- donor-acceptor interactions (1)
- donor–acceptor (1)
- donor–acceptor dyads (1)
- drug delivery (1)
- drugs (1)
- duplex structure (1)
- dye assembly (1)
- dye chemistry (1)
- electronic collective variables (1)
- electronic structure (1)
- electronic wavefunction (1)
- emission (1)
- enantiomerization (1)
- enantiomers (1)
- enzyme (1)
- enzyme purification (1)
- enzyme structure (1)
- enzymes (1)
- epitranscriptomics (1)
- ergosterol derivative (1)
- ethenoanthracenes (1)
- excimer (1)
- excimer formation (1)
- extractives (1)
- ferroelectrics (1)
- films (1)
- flavenoids (1)
- flavonoids (1)
- flourescence quantum yield (1)
- fluerescence (1)
- fluorenscence (1)
- fluorescence resonance energy transfer (1)
- fluorescence spectroscopy (1)
- fluorescent (1)
- fluorescent probes (1)
- fluorogen-activating RNA aptamer (FLAP) (1)
- fluoxetine (1)
- flux (1)
- folded macrocyles (1)
- folding (1)
- folding landscapes (1)
- functionalization (1)
- generation and rearrangement (1)
- glycocalyx (1)
- glycosphingolipids (1)
- growth (1)
- guttiferae (1)
- hMSC-TERT (1)
- halichondria panicea (1)
- heavy metals (1)
- helicene (1)
- heterocycles (1)
- hexakisadducts (1)
- high-temperature NMR (1)
- highly substituted (1)
- homochiral dimer (1)
- host-guest systems (1)
- hybrid materials (1)
- hydrazone (1)
- hydrocarbons (1)
- hydrolysis (1)
- hydroxylation (1)
- imaging (1)
- imidization (1)
- in vitro Selection (1)
- induced phase transition (1)
- inflammation (1)
- intersystem crossing (1)
- intrinsic free space (1)
- invasion (1)
- inflammatory response (1)
- ion pairing (1)
- iron oxide nanoparticles (1)
- isomorphic nucleobase analog (1)
- key structure - fluorescence activation relationships (SFARs) (1)
- kinetics of thermolysis (1)
- lH-Cyclopropa[a]naphthalenes (1)
- large stokes shift (1)
- laser (1)
- lectin (1)
- ligand binding (1)
- ligands (1)
- liposome (1)
- liquid crystal alignment (1)
- livingstonei (1)
- macrocycle (1)
- major depression (1)
- marine bacteria (1)
- marine fungi (1)
- marine macroalgae (1)
- marine natural products (1)
- marine sponge (1)
- materials (1)
- materials design (1)
- measles (1)
- mechanism (1)
- merocyanine (1)
- merocyanine dyes/pigments (1)
- mesogens (1)
- metabolic analysis (1)
- metabolic glycoengineering (1)
- metadynamics (1)
- metal complexenes (1)
- metal-to-ligand charge transfer (MLCT) (1)
- metallomacrocycles (1)
- methyl viologen (1)
- methyltransferase (1)
- micelles (1)
- microbiology (1)
- microbiology techniques (1)
- microscopy (1)
- migration (1)
- minimal inhibitory concentration (1)
- mobility (1)
- modified monosaccharides (1)
- molecular (1)
- molecular capsules (1)
- molecular dynamics (1)
- molecules (1)
- mtrogen extruston (1)
- multiflora (1)
- multimetallic complexes (1)
- multiple myeloma (1)
- nanoparticles (1)
- nanorods and nanosheets (1)
- nanoscale imaging (1)
- nanosegregation (1)
- nanotube (1)
- naphthalene diimide (1)
- naphthylisoquinoline alkaloid (1)
- naphthylisoquinoline alkaloids (1)
- narrow bandwidth (1)
- natural products (1)
- near infrared emitter (1)
- near-infrared sensitivity (1)
- non-fullerene acceptors (1)
- noncovalent interactions (1)
- nonfullerene acceptors (1)
- nucleation elongation (1)
- nucleation-elongation (1)
- nucleation-elongation model (1)
- nucleoside modification recognition (1)
- obstructive pulmonary disease (1)
- oligothiophene (1)
- oligothiophenes (1)
- optical materials (1)
- optics (1)
- organic semiconductors (1)
- organic compounds (1)
- organic light emitting diodes (1)
- organization (1)
- orylation (1)
- oxidation (1)
- pancreatic cancer (1)
- parallel polar dimers (1)
- pentaketide (1)
- peptide backbone (1)
- perylene bisimide dyes (1)
- perylene bisimide hydrogels (1)
- perylene bismide dye (1)
- perylene imide (1)
- perylenebisimide (1)
- perylenebisimide dyes (1)
- phenazine (1)
- phenyl-substituted (1)
- phenylboronate (1)
- phosphodiesterase-4 inhibitor (1)
- photochemical (1)
- photoconductive interlayer (1)
- photoluminescence (1)
- photosenitizers (1)
- photosensitization (1)
- phthalocyanines (1)
- platinum complexes (1)
- pol(2-oxazoline) (1)
- polarizing optical microscopy (1)
- poly(2-oxazine) (1)
- polycycles (1)
- polycyclic (1)
- polycyclic aromatic hydrocarbon (1)
- polymer drug interaction (1)
- polymorphism (1)
- polyoxazolines (1)
- polypyridyl complexes (1)
- porous materials (1)
- porousmaterials (1)
- porphyrins (1)
- probes (1)
- protease inhibition (1)
- proteasome inhibitor resistance (1)
- proteasome subunit beta type-5 (PSMB5) (1)
- push–pull thienylthiazole (1)
- pyrene (1)
- quantum chemical analysis (1)
- quantum optics (1)
- racemization (1)
- radical (1)
- radical anion (1)
- reabsorption (1)
- real-time NMR spectroscopy (1)
- rearrangement (1)
- recombinant proteins (1)
- redox (1)
- regulatory T cells (1)
- regulatory T cells (Treg) (1)
- renew-able fuels (1)
- rhizophoraceae (1)
- ribozymes (1)
- rigidification (1)
- rofumilast (1)
- room-temperature phosphorescence (RTP) (1)
- rotational diffusion (1)
- ruthenium catalysts (1)
- sSupramolecular interaction (1)
- seagrass (1)
- self-sorting (1)
- separation techniques (1)
- shape-amphiphiles (1)
- short-range order (1)
- sialic acids (1)
- simulated intestinal fluid (1)
- single crystal structure (1)
- site-specific RNA labeling (1)
- six-membered (1)
- social self‐sorting (1)
- solar cells (1)
- solar fuels (1)
- solid-state NMR (1)
- solid-state NMR spectroscopy (1)
- solid‐state emission (1)
- solubility (1)
- solvatochromism (1)
- solvolysis of (1)
- spectroscopic analysis (1)
- sphingolipid expansion microscopy (1)
- sphingomyelinase (1)
- sphingosine (1)
- sphingosine 1-phosphate (1)
- sphingosine kinases (1)
- stability (1)
- star-shaped compounds (1)
- starazine (1)
- starphene analogue (1)
- stereospecific sythesis (1)
- sterubin (1)
- stokes shift (1)
- structural biology (1)
- structural changes (1)
- structural dynamics (1)
- structure probes (1)
- structure probing (1)
- structure–function relation (1)
- structure–property relation (1)
- subphthalocyanine (1)
- substituted (1)
- substituted 2-oxo- dimethyl esters (1)
- superparamagnetism (1)
- superstructure (1)
- supramolecular assembly (1)
- supramolecular folding (1)
- supramolecular materials (1)
- supramolecular polymerization (1)
- supramolecular polymers (1)
- survival (1)
- sustainable energy source (1)
- swallow-tail (1)
- systems (1)
- template catalysis (1)
- tenofovir (1)
- tethya aurantium (1)
- tetracoordinated boron (1)
- tetromycin (1)
- theranostics (1)
- thin-film transistors (1)
- time-resolved impulsive stimulated raman spectroscopy (1)
- tissue engineering (1)
- transient absorption (1)
- triarylamine (1)
- triarylborane (1)
- trinuclear (1)
- triplet (1)
- triplet sensitization (1)
- two-dimensional nanostructures (1)
- umbrella-shaped mesogens (1)
- upconversion (1)
- upramolecular polymerization process (1)
- vacuum processable (1)
- vibrational coherence (1)
- viral epidemiology (1)
- viral infection (1)
- water oxidation catalysis (1)
- y-Oxoketenes (1)
- zooxanthellae (1)
- ß-Lactones (1)
- ß-unsaturated (1)
- β-Lactones (1)
- δ-Lactones (1)
- δ-chloro- (1)
- π-Konjugierte Systeme (1)
- π-conjugated systems (1)
- π-extension (1)
- π-π-interactions (1)
- π–π Stacking (1)
Institute
- Institut für Organische Chemie (310) (remove)
Sonstige beteiligte Institutionen
- Agricultural Center, BASF SE, 67117 Limburgerhof, Germany (1)
- Cluster of Excellence "Multiscale Bioimaging: from Molecular Machines to Networks of Excitable Cells, Göttingen (1)
- Department of Cellular Biochemistry, University Medical Center Göttingen (1)
- Department of Cellular Biochemistry, University Medical Centre Göttingen (1)
- Department of Molecular Biology, University Medical Centre Göttingen (1)
- Georg August University School of Science (1)
- Göttingen Center for Molecular Biosciences, University of Göttingen (1)
- Helmholtz Institute for RNA-based Infection Biology (HIRI), Josef-Schneider-Straße 2/D15, DE-97080 Wuerzburg, Germany (1)
- Institut für Molekulare Infektionsbiologie (MIB) der Universität Würzburg (1)
- Institute of Cancer Research (ICR) London (1)
EU-Project number / Contract (GA) number
- 682586 (15)
- 787937 (12)
- 693023 (2)
- 242175-VascuBone (1)
- 242175‐VascuBone (1)
- 643238 (1)
- 654000 (1)
- 715923 (1)
- LaserLab Europe (LLC001917) (1)
To circumvent time-consuming clinical trials, testing whether existing drugs are effective inhibitors of SARS-CoV-2, has led to the discovery of Remdesivir. We decided to follow this path and screened approved medications "off-label" against SARS-CoV-2. Fluoxetine inhibited SARS-CoV-2 at a concentration of 0.8 mu g/ml significantly in these screenings, and the EC50 was determined with 387 ng/ml. Furthermore, Fluoxetine reduced viral infectivity in precision-cut human lung slices showing its activity in relevant human tissue targeted in severe infections. Fluoxetine treatment resulted in a decrease in viral protein expression. Fluoxetine is a racemate consisting of both stereoisomers, while the S-form is the dominant serotonin reuptake inhibitor. We found that both isomers show similar activity on the virus, indicating that the R-form might specifically be used for SARS-CoV-2 treatment. Fluoxetine inhibited neither Rabies virus, human respiratory syncytial virus replication nor the Human Herpesvirus 8 or Herpes simplex virus type 1 gene expression, indicating that it acts virus-specific. Moreover, since it is known that Fluoxetine inhibits cytokine release, we see the role of Fluoxetine in the treatment of SARS-CoV-2 infected patients of risk groups.
In this communication, we demonstrate a novel approach to prepare a discrete dimer of chiral phthalocyanine (Pc) by exploiting the flexible molecular geometry of helicenes, which enables structural interlocking and strong aggregation tendency of Pcs. Synthesized [7]helicene-Pc hybrid molecular structure, zinc-[7]helicenocyanine (Zn-7HPc), exclusively forms a stable dimeric pair consisting of two homochiral molecules. The dimerization constants were estimated to be as high as 8.96×10\(^6\) M\(^{−1}\) and 3.42×107 M\(^{−1}\) in THF and DMSO, respectively, indicating remarkable stability of dimer. In addition, Zn\(^{-7}\)HPc exhibited chiral self-sorting behavior, which resulted in preferential formation of a homochiral dimer also in the racemic sample. Two phthalocyanine subunits in the dimeric form strongly communicate with each other as revealed by a large comproportionation constant and observation of an IV-CT band for the thermodynamically stable mixed-valence state.
Stereospecific Synthesis and Photophysical Properties of Propeller-Shaped C\(_{90}\)H\(_{48}\) PAH
(2019)
Herein, we have synthesized an enantiomerically pure propeller‐shaped PAH, C\(_{90}\)H\(_{48}\), possessing three [7]helicene and three [5]helicene subunits. This compound can be obtained in gram quantities in a straightforward manner. The photophysical and chiroptical properties were investigated using UV/Vis absorption and emission, optical rotation and circular dichroism spectroscopy, supported by DFT calculations. The nonlinear optical properties were investigated by two‐photon absorption measurements using linearly and circularly polarized light. The extremely twisted structure and packing of the homochiral compound were investigated by single‐crystal X‐ray diffraction analysis.
Marine organisms and their associated microbes are rich in diverse chemical leads. With the development of marine biotechnology, a considerable number of research activities are focused on marine bacteria and fungi-derived bioactive compounds. Marine bacteria and fungi are ranked on the top of the hierarchy of all organisms, as they are responsible for producing a wide range of bioactive secondary metabolites with possible pharmaceutical applications. Thus, they have the potential to provide future drugs against challenging diseases, such as cancer, a range of viral diseases, malaria, and inflammation. This review aims at describing the literature on secondary metabolites that have been obtained from Scleractinian-associated organisms including bacteria, fungi, and zooxanthellae, with full coverage of the period from 1982 to 2020, as well as illustrating their biological activities and structure activity relationship (SAR). Moreover, all these compounds were filtered based on ADME analysis to determine their physicochemical properties, and 15 compounds were selected. The selected compounds were virtually investigated for potential inhibition for SARS-CoV-2 targets using molecular docking studies. Promising potential results against SARS-CoV-2 RNA dependent RNA polymerase (RdRp) and methyltransferase (nsp16) are presented.
A Calix[4]arene‐Based Cyclic Dinuclear Ruthenium Complex for Light‐Driven Catalytic Water Oxidation
(2021)
A cyclic dinuclear ruthenium(bda) (bda: 2,2’‐bipyridine‐6,6’‐dicarboxylate) complex equipped with oligo(ethylene glycol)‐functionalized axial calix[4]arene ligands has been synthesized for homogenous catalytic water oxidation. This novel Ru(bda) macrocycle showed significantly increased catalytic activity in chemical and photocatalytic water oxidation compared to the archetype mononuclear reference [Ru(bda)(pic)\(_2\)]. Kinetic investigations, including kinetic isotope effect studies, disclosed a unimolecular water nucleophilic attack mechanism of this novel dinuclear water oxidation catalyst (WOC) under the involvement of the second coordination sphere. Photocatalytic water oxidation with this cyclic dinuclear Ru complex using [Ru(bpy)\(_3\)]Cl\(_2\) as a standard photosensitizer revealed a turnover frequency of 15.5 s\(^{−1}\) and a turnover number of 460. This so far highest photocatalytic performance reported for a Ru(bda) complex underlines the potential of this water‐soluble WOC for artificial photosynthesis.
Photocatalytic water oxidation is a promising process for the production of solar fuels and the elucidation of factors that influence this process is of high significance. Thus, we have studied in detail light‐driven water oxidation with a trinuclear Ru(bda) (bda: 2,2’‐bipyridine‐6,6’‐dicarboxylate) macrocycle MC3 and its highly water soluble derivative m‐CH\(_2\)NMe\(_2\)‐MC3 using a series of ruthenium tris(bipyridine) complexes as photosensitizers under varied reaction conditions. Our investigations showed that the catalytic activities of these Ru macrocycles are significantly affected by the choice of photosensitizer (PS) and reaction media, in addition to buffer concentration, light intensity and concentration of the sensitizer. Our steady‐state and transient spectroscopic studies revealed that the photocatalytic performance of trinuclear Ru(bda) macrocycles is not limited by their intrinsic catalytic activities but rather by the efficiency of photogeneration of oxidant PS\(^+\) and its ability to act as an oxidizing agent to the catalysts as both are strongly dependent on the choice of photosensitizer and the amount of employed organic co‐solvent.
Multimetallic complexes with extended and highly conjugated bis-2,2':6',2''-terpyridyl bridging ligands, which present building blocks for coordination polymers, are investigated with respect to their ability to act as light-harvesting antennae. The investigated species combine Ru(II)- with Os(II)- and Fe(II)-terpyridyl chromophores, the latter acting as energy sinks. Due to the extended conjugated system the ligands are able to prolong the lifetime of the \(^3\)MLCT states compared to unsubstituted terpyridyl species by delocalization and energetic stabilization of the \(^3\)MLCT states. This concept is applied for the first time to Fe(II) terpyridyl species and results in an exceptionally long lifetime of 23 ps for the Fe(II) \(^3\)MLCT state. While partial energy (>80%) transfer is observed between the Ru(II) and Fe(II) centers with a time-constant of 15 ps, excitation energy is transferred completely from the Ru(II) to the Os(II) center within the first 200 fs after excitation.
Boric acid (BA) has been used as a transparent glass matrix for optical materials for over 100 years. However, recently, apparent room-temperature phosphorescence (RTP) from BA (crystalline and powder states) was reported (Zheng et al., Angew. Chem. Int. Ed. 2021, 60, 9500) when irradiated at 280 nm under ambient conditions. We suspected that RTP from their BA sample was induced by an unidentified impurity. Our experimental results show that pure BA synthesized from B(OMe)\(_{3}\) does not luminesce in the solid state when irradiated at 250–400 nm, while commercial BA indeed (faintly) luminesces. Our theoretical calculations show that neither individual BA molecules nor aggregates would absorb light at >175 nm, and we observe no absorption of solid pure BA experimentally at >200 nm. Therefore, it is not possible for pure BA to be excited at >250 nm even in the solid state. Thus, pure BA does not display RTP, whereas trace impurities can induce RTP.
Designing highly efficient purely organic phosphors at room temperature remains a challenge because of fast non-radiative processes and slow intersystem crossing (ISC) rates. The majority of them emit only single component phosphorescence. Herein, we have prepared 3 isomers (o, m, p-bromophenyl)-bis(2,6-dimethylphenyl)boranes. Among the 3 isomers (o-, m- and p-BrTAB) synthesized, the ortho-one is the only one which shows dual phosphorescence, with a short lifetime of 0.8 ms and a long lifetime of 234 ms in the crystalline state at room temperature. Based on theoretical calculations and crystal structure analysis of o-BrTAB, the short lifetime component is ascribed to the T\(^M_1\) state of the monomer which emits the higher energy phosphorescence. The long-lived, lower energy phosphorescence emission is attributed to the T\(^A_1\) state of an aggregate, with multiple intermolecular interactions existing in crystalline o-BrTAB inhibiting nonradiative decay and stabilizing the triplet states efficiently.
The minimum energy path for the reaction O(\(^3\)P\(_g\)) + C\(_2\)H\(_4\)(\(^1\)A\(_g\)) has been calculated by optimizing all relevant geometrical parameters along the approach of oxygen to ethene. A barrier of 4.7 kcal/mol in the \(^3\)A"( ... 9a'\(^2\)- 10a'3a") potential energy surface and an energy difference of 14.4 kcal/mol between the product and the fragments is found at the multireference-configuration interaction level. The corresponding values at the lower-level treatment CASSCF are 9 kcal/mol for the barrier and 9 kcal/mol for the depth of the potential; this shows the importance of inclusion of electron correlation. The barrier for CH\(_2\) rotation for the lowestenergy structure (asymmetric OC\(_2\)H\(_4\)) is around 5 kcal/mol. The energy gap to the first excited state \(^3\)A'( ... 9a'l0a'3a'12) is found tobe 3.6 kcal/mol in MRD-CI calculations at the ground-state minimum. Comparison with \(^3\)CH\(_2\) + C\(_2\)H\(_4\) shows that in this system the lowest-energy surface is \(^3\)A', i.e., the state which is the excited state in 0 + C\(_2\)H\(_4\). This difference in energy ordering of \(^3\)A' and \(^3\)A" states results from the fact that the p\(_x\), p\(_y\), p\(_z\) degeneracy of oxygen orbitals is lifted in \(^3\)CH\(_2\)leading to b\(_1\), b\(_2\). and a\(_1\) MOs whereby the lowest b\(_2\) (a") remains doubly occupied; as a consequence, the reaction pattem between the oxygen and \(^3\)CH\(_2\) approach is different, which is also quite apparent in the calculated charge transfer.