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Durch Untersuchungen zur Reaktivität von Boryl- und Boridverbindungen konnten deren Bindungssituationen aufgeklärt und neuartige Koordinationsmotive von Übergangsmetall-Bor-Verbindungen erhalten werden. Die erhaltenen Verbindungen wurden mittels NMR-Spektroskopie, IR-Spektroskopie, Elementaranalyse und Röntgendiffraktometrie untersucht und zusätzlich wurden DFT-Rechnungen angefertigt.
An verschieden substituierten Eisenborylkomplexen wurden Reaktivitätsuntersuchungen gegenüber Halogenidabstraktionsmitteln und Reduktionsmitteln durchgeführt und im Falle der Boridkomplexe wurden Verbindungen mit bis dato unbekanntem Strukturmotiv erhalten.
The aim of this thesis is to examine the competition patterns that exist between originators and generics by focusing on the articulations between regulation and incentives to innovate.
Once the characteristics of regulation in pharmaceutical markets is reviewed in the first chapter and an analysis of some current challenges related to cost-containment measures and innovation issues is performed, then in the second chapter, an empirical study is performed to investigate substitution patterns. Based on the EC´s merger decisions in the pharmaceutical sector from 1989 to 2011, this study stresses the key criteria to define the scope of the relevant product market based on substitution patterns and shows the trend towards a narrower market in time.
Chapters three and four aim to analyse in depth two widespread measures, the internal reference pricing system in off-patent markets, and risk-sharing schemes in patent-protected markets. By taking into account informational advantages of originators over generics, the third chapter shows the extent to which the implementation of a reference price for off-patent markets can contribute in promoting innovation.
Finally, in the fourth chapter, the modeling of risk-sharing schemes explains how such schemes can help in solving moral hazard and adverse selection issues by continuously giving pharmaceutical companies incentives to innovate and supplying medicinal products of a higher quality.
Zentrale Befunde:
Erstmals wird in Deutschland eine Studie durchgeführt, die die Stressbelastung von GrundschülerInnen am Übergang von der Primar- in die Sekundarstufe erfasst. Die schriftliche Befragung von 1.620 Eltern aus den Bundesländern Bayern und Hessen zeigt dabei, dass
• die an Schulnoten gekoppelte und bindende Übertrittsregelung in Bayern zu einer höheren Stressbelastung bei Kindern führt als die hessische Form der beratenden Übertrittsempfehlung.
• vor allem Kinder aus bildungsfernen Familien einer hohen Stressbelastung ausgesetzt sind, weil sie weniger über stresshemmende Schutzfaktoren verfügen als Kinder aus bildungsnahen Elternhäusern.
• Eltern durch überzogene und unrealistische Bildungserwartungen die Stressbelastung für ihre Kinder nochmals erhöhen und hierdurch zur Gefährdung ihrer Kinder beitragen.
• die Grundschulkinder in Bayern, die an der Notenschwelle zwischen Mittel- und Realschulempfehlung liegen, eine erhebliche Risikogruppe darstellen. Die SchülerInnen weisen nicht nur die höchsten Stresswerte auf, sie sind auch die einzigen SchülerInnen, bei denen der Stress von der dritten zur vierten Klasse dramatisch ansteigt.
Folgerungen für die Praxis:
Die Ergebnisse der Querschnittstudie müssen noch durch längsschnittliche Verlaufsdaten repliziert werden, deuten aber bereits in der vorliegenden Form an, dass
• der Schulübergang im Alter von zehn Jahren in einer sensiblen Entwicklungsphase der Kinder Stress erzeugt und somit zeitlich zu früh ansetzt,
• bindende Schulübertrittszuweisungen wie im bayerischen Modell die Stressbelastung der Kinder deutlich erhöhen,
• für eine salutogene Entwicklung der Kinder Beratungsmodelle gegenüber Zuweisungsmodellen beim Schulübertritt mit Nachdruck zu bevorzugen sind,
• Eltern frühzeitig und aktiv über den weiteren Bildungsweg ihrer Kinder informiert werden müssen, um zusätzliche Stressbelastungen zu vermeiden,
• vor allem und sehr zeitnah die Stressbelastung der Risikogruppe gemindert werden muss, die zwischen Mittel- und Realschulzuweisungen steht.
Bereits seit Anfang der 1990er Jahre wird jungen Wissenschaftlern im Vorfeld der Tagung "Wirtschaftsinformatik" ein Doctoral Consortium als unterstützendes Forum angeboten. Diese Einrichtung wurde auch zur größten Internationalen Konferenz der Wirtschaftsinformatik, der WI 2015 in Osnabrück fortgeführt. Dieser Band fasst die zum Vortag ausgewählten Beiträge zusammen.
Division of labor represents a major advantage of social insect communities that accounts for their enormous ecological success. In colonies of the honeybee, Apis mellifera, division of labor comprises different tasks of fertile queens and drones (males) and, in general, sterile female workers. Division of labor also occurs among workers in form of an age-related polyethism. This helps them to deal with the great variety of tasks within the colony. After adult eclosion, workers spend around three weeks with various duties inside the hive such as tending the brood or cleaning and building cells. After this period workers switch to outdoor tasks and become foragers collecting nectar, pollen and water. With this behavioral transition, workers face tremendous changes in their sensory environment. In particular, visual sensory stimuli become important, but also the olfactory world changes. Foragers have to perform a completely new behavioral repertoire ranging from long distance navigation based on landmark orientation and polarized-skylight information to learning and memory tasks associated with finding profitable food sources. However, behavioral maturation is not a purely age-related internal program associated with a change, for example, in juvenile hormone titers. External factors such as primer pheromones like the brood pheromone or queen mandibular pheromone can modulate the timing of this transition. In this way colonies are able to flexibly adjust their work force distribution between indoor and outdoor tasks depending on the actual needs of the colony. Besides certain physiological changes, mainly affecting glandular tissue, the transition from indoor to outdoor tasks requires significant adaptations in sensory and higher-order integration centers of the brain.
The mushroom bodies integrate olfactory, visual, gustatory and mechanosensory information. Furthermore, they play important roles in learning and memory processes. It is therefore not surprising that the mushroom bodies, in particular their main input region, the calyx, undergo volumetric neuronal plasticity. Similar to behavioral maturation, plastic changes of the mushroom bodies are associated with age, but are also to be affected by modulating factors such as task and experience.
In my thesis, I analyzed in detail the neuronal processes underlying volumetric plasticity in the mushroom body. Immunohistochemical labeling of synaptic proteins combined with quantitative 3D confocal imaging revealed that the volume increase of the mushroom body calyx is largely caused by the growth of the Kenyon cell dendritic network. This outgrowth is accompanied by changes in the synaptic architecture of the mushroom body calyx, which is organized in a distinct pattern of synaptic complexes, so called microglomeruli. During the first week of natural adult maturation microglomeruli remain constant in total number. With subsequent behavioral transition from indoor duties to foraging, microglomeruli are pruned while the Kenyon cell dendritic network is still growing. As a result of these processes, the mushroom body calyx neuropil volume enlarges while the total number of microgloumeruli becomes reduced in foragers compared to indoor workers. In the visual subcompartments (calyx collar) this process is induced by visual sensory stimuli as the beginning of pruning correlates with the time window when workers start their first orientation flights. The high level of analysis of cellular and subcellular process underlying structural plasticity of the mushroom body calyx during natural maturation will serve as a framework for future investigations of behavioral plasticity in the honeybee.
The transition to foraging is not purely age-dependent, but gets modulated, for example, by the presence of foragers. Ethyl oleate, a primer pheromone that is present only in foragers, was shown to delay the onset of foraging in nurse bees. Using artificial application of additional ethyl oleate in triple cohort colonies, I tested whether it directly affects adult neuronal plasticity in the visual input region of the mushroom body calyx. As the pheromonal treatment failed to induce a clear behavioral phenotype (delayed onset of foraging) it was not possible to show a direct link between the exposure to additional ethyl oleate and neuronal plasticity in mushroom body calyx. However, the general results on synaptic maturation confirmed my data of natural maturation processes in the mushroom body calyx.
Given the result that dendritic plasticity is a major contributor to neuronal plasticity in the mushroom body calyx associated with division of labor, the question arose which proteins could be involved in mediating these effects. Calcium/calmodulin-dependent protein kinase II (CaMKII) especially in mammals, but also in insects (Drosophila, Cockroach), was shown to be involved in facilitating learning and memory processes like long-term synaptic potentiation. In addition to presynaptic effects, the protein was also revealed to directly interact with cytoskeleton elements in the postsynapse. It therefore is a likely candidate to mediate structural synaptic plasticity. As part of my thesis, the presence and distribution of CaMKII was analyzed, and the results showed that the protein is highly concentrated in a distinct subpopulation of the mushroom body intrinsic neurons, the noncompact Kenyon cells. The dendritic network of this population arborizes in two calyx subregions: one receiving mainly olfactory input – the lip – and the collar receiving visual input. This distribution pattern did not change with age or task. The high concentration of CaMKII in dendritic spines and its overlap with f-actin indicates that CaMKII could be a key player inducing structural neuronal plasticity associated with learning and memory formation and/or behavioral transitions related to division of labor. Interestingly CaMKII immunoreactivity was absent in the basal ring, another subregion of the mushroom body calyx formed almost exclusively by the inner compact Kenyon cells and known to receive combined visual and olfactory input. This indicates differences of this mushroom body subregion regarding the molecular mechanisms controlling plastic changes in corresponding Kenyon cells.
How is timing of behavioral and neuronal plasticity regulated? The primer pheromone ethyl oleate was found in high concentrations on foragers and was shown to influence behavioral maturation by delaying the onset of foraging when artificially applied in elevated concentrations. But how is ethyl oleate transferred and how does it shift the work force distribution between indoor and outdoor tasks? Previous work showed that ethyl oleate concentrations are highest in the honeycrop of foragers and suggested that it is transferred and communicated inside the colony via trophallaxis. The results of this thesis however clearly show, that ethyl oleate was not present inside the honey crop or the regurgitate, but rather in the surrounding tissue of the honey crop. As additionally the second highest concentration of ethyl oleate was measured on the surface of the cuticle of forgers, trophallaxis was ruled out as a mode of transmission. Neurophysiological measurements at the level of the antennae (electroantennogram recordings) and the first olfactory neuropil (calcium imaging of activity in the antennal lobe) revealed that the primer pheromone ethyl oleate is received and processed as an olfactory stimulus. Appetitive olfactory conditioning using the proboscis extension response as a behavioral paradigm showed that ethyl oleate can be associated with a sugar reward. This indicates that workers are able to perceive, learn and memorize the presence of this pheromone. As ethyl oleate had to be presented by a heated stimulation device at close range, it can be concluded that this primer pheromone acts via close range/contact chemoreception through the olfactory system. This is also supported by previous behavioral observations.
Taken together, the findings presented in this thesis revealed structural changes in the synaptic architecture of the mushroom body calyx associated with division of labor. For the primer pheromone ethyl oleate, which modulates the transition from nursing to foraging, the results clearly showed that it is received via the olfactory system and presumably acts via this pathway. However, manipulation experiments did not indicate a direct effect of ethyl oleate on synaptic plasticity. At the molecular level, CaMKII is a prime candidate to mediate structural synaptic plasticity in the mushroom body calyx. Future combined structural and functional experiments are needed to finally link the activity of primer pheromones like ethyl oleate to the molecular pathways mediating behavioral and synaptic plasticity associated with division of labor in Apis mellifera. The here identified underlying processes will serve as excellent models for a general understanding of fundamental mechanisms promoting behavioral plasticity.
Performance Assessment of Resource Management Strategies for Cellular and Wireless Mesh Networks
(2015)
The rapid growth in the field of communication networks has been truly amazing in the last decades. We are currently experiencing a continuation thereof with an increase in traffic and the emergence of new fields of application. In particular, the latter is interesting since due to advances in the networks and new devices, such as smartphones, tablet PCs, and all kinds of Internet-connected devices, new additional applications arise from different areas. What applies for all these services is that they come from very different directions and belong to different user groups. This results in a very heterogeneous application mix with different requirements and needs on the access networks.
The applications within these networks typically use the network technology as a matter of course, and expect that it works in all situations and for all sorts of purposes without any further intervention. Mobile TV, for example, assumes that the cellular networks support the streaming of video data. Likewise, mobile-connected electricity meters rely on the timely transmission of accounting data for electricity billing. From the perspective of the communication networks, this requires not only the technical realization for the individual case, but a broad consideration of all circumstances and all requirements of special devices and applications of the users.
Such a comprehensive consideration of all eventualities can only be achieved by a dynamic, customized, and intelligent management of the transmission resources. This management requires to exploit the theoretical capacity as much as possible while also taking system and network architecture as well as user and application demands into account. Hence, for a high level of customer satisfaction, all requirements of the customers and the applications need to be considered, which requires a multi-faceted resource management.
The prerequisite for supporting all devices and applications is consequently a holistic resource management at different levels. At the physical level, the technical possibilities provided by different access technologies, e.g., more transmission antennas, modulation and coding of data, possible cooperation between network elements, etc., need to be exploited on the one hand. On the other hand, interference and changing network conditions have to be counteracted at physical level. On the application and user level, the focus should be on the customer demands due to the currently increasing amount of different devices and diverse applications (medical, hobby, entertainment, business, civil protection, etc.).
The intention of this thesis is the development, investigation, and evaluation of a holistic resource management with respect to new application use cases and requirements for the networks. Therefore, different communication layers are investigated and corresponding approaches are developed using simulative methods as well as practical emulation in testbeds. The new approaches are designed with respect to different complexity and implementation levels in order to cover the design space of resource management in a systematic way. Since the approaches cannot be evaluated generally for all types of access networks, network-specific use cases and evaluations are finally carried out in addition to the conceptual design and the modeling of the scenario.
The first part is concerned with management of resources at physical layer. We study distributed resource allocation approaches under different settings. Due to the ambiguous performance objectives, a high spectrum reuse is conducted in current cellular networks. This results in possible interference between cells that transmit on the same frequencies. The focus is on the identification of approaches that are able to mitigate such interference.
Due to the heterogeneity of the applications in the networks, increasingly different application-specific requirements are experienced by the networks. Consequently, the focus is shifted in the second part from optimization of network parameters to consideration and integration of the application and user needs by adjusting network parameters. Therefore, application-aware resource management is introduced to enable efficient and customized access networks.
As indicated before, approaches cannot be evaluated generally for all types of access networks. Consequently, the third contribution is the definition and realization of the application-aware paradigm in different access networks. First, we address multi-hop wireless mesh networks. Finally, we focus with the fourth contribution on cellular networks. Application-aware resource management is applied here to the air interface between user device and the base station. Especially in cellular networks, the intensive cost-driven competition among the different operators facilitates the usage of such a resource management to provide cost-efficient and customized networks with respect to the running applications.