Refine
Has Fulltext
- yes (8)
Is part of the Bibliography
- yes (8)
Document Type
- Journal article (6)
- Doctoral Thesis (2)
Keywords
- water purification (2)
- Adsorption (1)
- CD117 (1)
- CK5 (1)
- Doppler-Verbreiterung (1)
- EGFR (1)
- Eisenoxide (1)
- FE (1)
- Ferrite (1)
- Magnetisches Trennverfahren (1)
Institute
EU-Project number / Contract (GA) number
- 645993 (1)
Micron‐sized supraparticles, consisting of a plurality of discrete nano‐ and microscale functional units, are assembled and fused by means of a droplet extrusion process. By combining nano magnetite, activated carbon, and conductive carbon with a polymeric binder matrix, particles are obtained which unite good magnetic properties, electrical conductivity, and adsorber activity through the high accessible surface area of the incorporated activated carbon of about 570 m\(^{2}\) g\(^{-1}\), thereby enabling a new approach toward sustainable water treatment processes. Due to the interplay of the components, it is possible to adsorb target substances, dissolved in the water which is demonstrated by the adsorption of the model dye methylene blue. A very fast adsorption kinetic and an adsorption capacity of about 400 mg g\(^{-1}\) is determined. By using the developed composite particles, it is also possible to electrochemically alter substances flowing through a magnetically‐stabilized fluidized‐bed reactor by electrochemically charging/discharging, significantly supported by the magnetic field enabling alternatingly optimum mobility/adsorption phases with contact/charging intervals. The electrochemical conversion can be increased up to 151% depending on the applied flow‐rate and electrical voltage. By applying an external magnetic field, a further increase of electrochemical conversion of up to 70% can be observed.
Here, we report a continuous flow synthesis of nano LDH, comprising a continuous precipitation process using static mixers and followed by an immediate cleaning process via a semi-continuous centrifuge to obtain the final product in one-go. Via this synthesis setup, it is possible to independently vary the concentrations of the reactants during precipitation and at the same time ensure constant reaction conditions and an immediate "quenching" of the precipitate due to "on the flow"-washing. We found that this paves the way to adjust the synthesis parameters in a way that the final morphology of the nano-LDH particles can be controlled to be either round or platelet-like.
Elektronische Spektroskopie und Photodissoziationsverhalten von heterocyclischen Biomolekülen
(2009)
Das Photodissoziationsverhalten der Pyrimidinbasen Thymin, Uracil und 5-Methylcytosin wurde mittels Photofragment-Dopplerspektroskopie und Photofragment-Imaging untersucht. Die Photodissoziation erfolgt in allen Fällen in einem statistischen Prozess nach Mehrphotonenabsorption. Von Purin wurde ebenfalls die Photodissoziation untersucht sowie das elektronische Spektrum des niedrigsten n-pi*-Zustands mittels Photofragment-Anregungsspektroskopie und [1+1']-REMPI-Spektroskopie gemessen. Purin zeigt bei den untersuchten Wellenlängen dasselbe Verhalten wie die Pyrimidinbasen. Das Elektronische Spektrum von Purin zeigt über einen Bereich von über 2000 cm^-1 vom Bandenursprung gut strukturierte Banden, von denen die meisten oberhalb 850 cm^-1 als Kombinationsbanden identifiziert wurden.
In der vorliegenden Arbeit wurden magnetische Kompositpartikel für den Einsatz in Flüssigkeiten entwickelt. Der Aufbau der Partikel erfolgte dabei modular, sodass eine Anpassung an verschiedene Einsatzmöglichkeiten realisierbar sein sollte. Die gezeigten Arbeiten bauen auf Partikeln bestehend aus magnetischen Nanopartikeln eingebettet in eine Silica-Matrix als Trägerpartikel auf, welche im Rahmen der vorliegenden Arbeit weiterentwickelt wurden. Der Schwerpunkt lag dabei auf der Entwicklung eines Adsorbermaterials für Phosphat als Funktionalisierung für die magnetischen Trägerpartikel, welches für den Einsatz der Entfernung von Phosphat aus kommunalem Abwasser geeignet sein sollte, sowie dessen Einsatz im Labor- und Technikumsmaßstab. Besonderes Augenmerk lag auf der umfassenden Charakterisierung des entwickelten Matrerials sowie der Aufklärung des Wirkmechanismus bei der Phosphatadsorption. Ein weiterer Teil der Arbeit beschäftigte sich mit der Steigerung der Magnetisierung des magnetischen Anteils der Partikel für eine verbesserte magnetische Abtrennung. Um die vielseitige Einsetzbarkeit der magnetischen Trägerpartikel zu demonstrieren, wurden abschließend weitere Funktionalisierungen für diese entwickelt und deren Anwendbarkeit grundlegend getestet. So wurde zum einen eine Modifizierung mit Komplexverbindungen und Metal-Organic Frameworks (MOF) realisiert mit dem möglichen Einsatzgebiet der Wasserdetektion in organischen Lösemitteln. Zum anderen wurde eine Beschichtung mit Kohlenstoff durchgeführt und die Entfernung von organischen Farbstoffmolekülen aus Wasser untersucht.
Molecular-based subclassifications of breast cancer are important for identifying treatment options and stratifying the prognosis in breast cancer. This study aimed to assess the prognosis relative to disease-free survival (DFS) and overall survival (OS) in patients with triple-negative breast cancer (TNBC) and other subtypes, using a biomarker panel including cytokeratin 5 (CK5), cluster of differentiation 117 (CD117), and epidermal growth factor receptor (EGFR). This cohort–case study included histologically confirmed breast carcinomas as cohort arm. From a total of 894 patients, 572 patients with early breast cancer, sufficient clinical data, and archived tumor tissue were included. Using the immunohistochemical markers CK5, CD117, and EGFR, two subgroups were formed: one with all three biomarkers negative (TBN) and one with at least one of those three biomarkers positive (non-TBN). There were significant differences between the two biomarker subgroups (TBN versus non-TBN) in TNBC for DFS (p = 0.04) and OS (p = 0.02), with higher survival rates (DFS and OS) in the non-TBN subgroup. In this study, we found the non-TBN subgroup of TNBC lesions with at least one positive biomarker of CK5, CD117, and/or EGFR, to be associated with longer DFS and OS.
Background
Aging is associated with progressive loss of musculoskeletal performance. Exercise interventions can improve physical function in the elderly but there is a paucity of comparative assessments in order to understand what specific goals can be achieved particularly with less demanding exercise interventions readily accessible for untrained men.
Methods
Prospective randomized, controlled, single center exploratory trial to compare four distinct exercise interventions, i.e. Resistance Training (RT), Whole Body Vibration Exercise (WBV), Qi Gong (QG) and wearing a Spinal orthosis (SO) for 6 months in men at risk for osteoporosis aged 65–90 years. Primary endpoint was change in isometric one repetition maximum force trunk strength for extension (TSE) and flexion (TSF) compared to baseline, secondary endpoints covered key parameters of geriatric functional assessment, including Handgrip Strength (HS), Chair-Rise-Test (CRT), Usual Gait Speed (UGS) and Timed-Up-and-Go (TUG).
Results
Altogether 47 men (mean age 77 ±6.1 years) were randomized to RT, (n = 11) WBV (n = 13), QG (n = 10) and SO(n = 13). RT, defined as reference exercise intervention, lead to significant improvements for TSE (p = 0.009) and TSF (p = 0.013) and was significantly superior in the between-group analysis for TSE (p = 0.038). Vibration exercise caused sign. Improvements in TSE (p = 0.014) and CRT (p = 0.005), the Spinal orthosis improved CRT (p = 0.003) and Gait Speed (p = 0.027), while the QG intervention did not attain any sig. Developments.
Subgroup analyses revealed most pronounced musculoskeletal progress in vulnerable patients (age ≥ 80 years, pre-sarcopenia, multimorbidity ≥3chronic diseases). Irrespective of the type of exercise, participants ≥80 years experienced significant gains in TSE (p = 0.029) and CRT (p = 0.017). Presarcopenic subjects (Skeletal muscle Index (SMI) ≤10.75 kg/m2) improved in TSE (p = 0.003), CRT (p = 0.001) and UGS (p = 0.016). Multimorbid participants achieved sig. Gains in TSE (p < 0.001), TSF (p = 0.002), UGS (p = 0.036) and HS (p = 0.046).
Conclusions
In this exploratory trial we found that simple exercise interventions are feasible in elderly men eliciting specific benefits, i.e. improvements are attained in those tasks addressed with the respective exercise modality. While targeted resistance training is superior in increasing TSE, alternative simple exercise interventions also appear to elicit beneficial effects, even in vulnerable patients, i.e. those with low muscle mass, above 80 years of age or multimorbidity.
The maximum magnetisation (saturation magnetisation) obtainable for iron oxide nanoparticles can be increased by doping the nanocrystals with non-magnetic elements such as zinc. Herein, we closely study how only slightly different synthesis approaches towards such doped nanoparticles strongly influence the resulting sub-nano/atomic structure. We compare two co-precipitation approaches, where we only vary the base (NaOH versus NH\(_3\)), and a thermal decomposition route. These methods are the most commonly applied ones for synthesising doped iron oxide nanoparticles. The measurable magnetisation change upon zinc doping is about the same for all systems. However, the sub-nano structure, which we studied with Mossbauer and X-ray absorption near edge spectroscopy, differs tremendously. We found evidence that a much more complex picture has to be drawn regarding what happens upon Zn doping compared to what textbooks tell us about the mechanism. Our work demonstrates that it is crucial to study the obtained structures very precisely when "playing'' with the atomic order in iron oxide nanocrystals.
Background
Accidental ingestion of fish bone is a common cause of otolaryngological emergency. Migration of the ingested bone into the thyroid gland, however, occurs very rarely. The associated clinical presentation, symptoms and duration of discomfort are also highly variable between patients and can be diagnostically challenging.
Case presentation
Here, we report the case of a 71-year-old female patient presenting with an ingested fish bone that migrated into the right thyroid lobe as a rare cause of suppurative thyroiditis with the clinical features of sepsis. We outline the diagnostic approach, peri- and intraoperative management as well as complications. It is proposed that besides endoscopy, imaging methods such as ultrasound or computed tomography may be necessary to verify the diagnosis and location of an ingested fish bone. Prompt surgical removal of the foreign body and resection of the infectious focus is recommended to minimize the risk of local inflammation, recurrent nerve lesions and septic complications arising from the spread of infection.
Conclusion
Fish bone migration into the thyroid gland is an extremely rare event, the successful detection and surgical management of which can be achieved through a careful interdisciplinary approach.