Filtern
Volltext vorhanden
- ja (1)
Gehört zur Bibliographie
- ja (1)
Erscheinungsjahr
- 2023 (1)
Dokumenttyp
Sprache
- Englisch (1) (entfernen)
Schlagworte
- amber light (1)
- decafluoroazobezene (1)
- peptide stapling (1)
- perfluoroarylation (1)
- photocontrol (1)
Institut
- Institut für Anorganische Chemie (1) (entfernen)
Amber Light Control of Peptide Secondary Structure by a Perfluoroaromatic Azobenzene Photoswitch
(2023)
The incorporation of photoswitches into the molecular structure of peptides and proteins enables their dynamic photocontrol in complex biological systems. Here, a perfluorinated azobenzene derivative triggered by amber light was site‐specifically conjugated to cysteines in a helical peptide by perfluoroarylation chemistry. In response to the photoisomerization (trans→cis) of the conjugated azobenzene with amber light, the secondary structure of the peptide was modulated from a disorganized into an amphiphilic helical structure.