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- perylene bisimide (13)
- preterm infants (13)
- reliability (13)
- replication (13)
- symbiosis (13)
- therapeutic drug monitoring (13)
- traumatic brain injury (13)
- working memory (13)
- Überleben (13)
- ALS (12)
- Adenosinrezeptor (12)
- Adhäsion (12)
- Altern (12)
- Aspergillose (12)
- Brain-derived neurotrophic factor (12)
- Comet Assay (12)
- Computer Center University of Wuerzburg (12)
- Dialyse (12)
- Diboren (12)
- Dopamin (12)
- ERP (12)
- FRET (12)
- Fibrose (12)
- Fluorescence (12)
- Gen (12)
- Genotoxizität (12)
- Grundschule (12)
- Hirntumor (12)
- Immunotherapy (12)
- Kinderheilkunde (12)
- Klima (12)
- Klimawandel (12)
- Kohlenstoff-Nanoröhre (12)
- Komplikationen (12)
- Kulturwissenschaften (12)
- Kutikula (12)
- Lymphom (12)
- Magnetische Kernresonanz (12)
- Medienkompetenz (12)
- Metastase (12)
- Modell (12)
- NFAT (12)
- Nanostrukturiertes Material (12)
- Netzhaut (12)
- Nigeria (12)
- Non-Hodgkin-Lymphom (12)
- Onkogen (12)
- PCR (12)
- PRRT (12)
- Pharmakologie (12)
- Pilzkörper (12)
- Polytrauma (12)
- Quality of Experience (12)
- Quantenchemie (12)
- Rekonstruktion (12)
- Religion (12)
- Replikation (12)
- Risikofaktor (12)
- Rotatorenmanschette (12)
- Ruthenium (12)
- SMN (12)
- SNP (12)
- Siliciumorganische Verbindungen (12)
- Spracherwerb (12)
- Toll-like-Rezeptoren (12)
- Ultrakurzer Lichtimpuls (12)
- Validierung (12)
- Zelladhäsion (12)
- age (12)
- animal model (12)
- antibody (12)
- autoantibodies (12)
- biofabrication (12)
- blood–brain barrier (12)
- carbenes (12)
- cartilage (12)
- catalysis (12)
- colorectal carcinoma (12)
- complications (12)
- database (12)
- dementia (12)
- drug delivery (12)
- dynamics (12)
- emotions (12)
- endothelium (12)
- enzyme replacement therapy (12)
- fear conditioning (12)
- genome (12)
- head and neck cancer (12)
- interaction (12)
- lymphocytes (12)
- malignant hyperthermia (12)
- measles (12)
- microarray (12)
- molecular beam epitaxy (12)
- monoclonal antibodies (12)
- neurology (12)
- neuropathy (12)
- optimization (12)
- pollen (12)
- polymers (12)
- proteomics (12)
- rats (12)
- recombination (12)
- screening (12)
- super-resolution microscopy (12)
- synaptic plasticity (12)
- systematic review (12)
- tinnitus (12)
- total knee arthroplasty (12)
- trabeculectomy (12)
- translation (12)
- ubiquitin (12)
- ultrasound (12)
- vitamin D (12)
- vorsprachliche Entwicklung (12)
- zebrafish (12)
- ++ (11)
- 3D (11)
- Alzheimer’s disease (11)
- Anorexia nervosa (11)
- Antigen CD8 (11)
- Arabidopsis (11)
- B-Zelle (11)
- Bioisosterie (11)
- Biosynthese (11)
- Bioverfügbarkeit (11)
- Bruchpilot (11)
- Candida (11)
- Chromatin (11)
- Click-Chemie (11)
- Computertomografie (11)
- Durchflusscytometrie (11)
- Dynamik (11)
- EGFR (11)
- Elektronentransfer (11)
- Enzym (11)
- Epidemiologie (11)
- Epidermaler Wachstumsfaktor-Rezeptor (11)
- Flavonoide (11)
- Fließverhalten (11)
- Fotovoltaik (11)
- Genom (11)
- Geschlecht (11)
- Hypoxie (11)
- Immuncytochemie (11)
- Japankärpfling (11)
- Knochen (11)
- Knochenersatz (11)
- Kolorektales Karzinom (11)
- LPS (11)
- Laser (11)
- Längsschnittuntersuchung (11)
- MS (11)
- Mais (11)
- Mathematik (11)
- Megakaryozyt (11)
- Mensch-Maschine-Kommunikation (11)
- Mesenchymale Stammzellen (11)
- Mesenchymzelle (11)
- Model (11)
- Monitoring (11)
- NIRS (11)
- Nanodiamant (11)
- Neuropathie (11)
- Niereninsuffizienz (11)
- Operation (11)
- Osteoinduktion (11)
- Parathormon (11)
- Perylenbisimid (11)
- Phylogenie (11)
- Proteaseinhibitor (11)
- Proteasen (11)
- Psychiatrie (11)
- Pulmonale Hypertonie (11)
- Quality of life (11)
- Quanten-Hall-Effekt (11)
- Reperfusion (11)
- Risikofaktoren (11)
- Salmonella (11)
- Schizophrenia (11)
- Schlafapnoe (11)
- Schließzelle (11)
- Schule (11)
- Schultergelenk (11)
- Schädel-Hirn-Trauma (11)
- Silicate (11)
- Skala (11)
- Small RNA (11)
- Sprache (11)
- Squark (11)
- Stammzellen (11)
- Sterblichkeit (11)
- Supraleitung (11)
- Symbiose (11)
- T cell (11)
- TWEAK (11)
- Training (11)
- Tuberkelbakterium (11)
- Tumor-Nekrose-Faktor <alpha> (11)
- USA (11)
- Ubiquitin (11)
- Vasodilatator-stimuliertes Phosphoprotein (11)
- Wahrnehmung (11)
- Westafrika (11)
- Zelltod (11)
- adhesion (11)
- allergy (11)
- amygdala (11)
- atrial fibrillation (11)
- biocompatibility (11)
- biofilm (11)
- cancer treatment (11)
- cell adhesion (11)
- cochlear implant (11)
- communication (11)
- coping (11)
- dosimetry (11)
- fluorescence microscopy (11)
- genomics (11)
- glioblastoma multiforme (11)
- heart rate (11)
- hypoxia (11)
- immunology (11)
- kinetics (11)
- lung (11)
- mechanism (11)
- meiosis (11)
- membrane proteins (11)
- microbiome (11)
- microglia (11)
- molecular dynamics (11)
- molecular imaging (11)
- nervous system (11)
- neural networks (11)
- neuroendocrine tumor (11)
- next generation sequencing (11)
- nuclear envelope (11)
- oncolytic virus (11)
- periodontitis (11)
- plasticity (11)
- pollination (11)
- randomized controlled trial (11)
- reactive oxygen species (11)
- relapse (11)
- review (11)
- safety (11)
- signaling (11)
- thrombosis (11)
- topological insulator (11)
- transport (11)
- tumor microenvironment (11)
- university (11)
- Alkohol (10)
- Alzheimer's disease (10)
- Antigen CD28 (10)
- Arzneimittelüberwachung (10)
- Atherosclerosis (10)
- BERA (10)
- BMP-2 (10)
- Bacteria (10)
- Bakterielle Infektion (10)
- Beschichtung (10)
- Bildverarbeitung (10)
- Bioinformatics (10)
- Biokompatibilität (10)
- Blazar (10)
- Borole (10)
- CRISPR/Cas-Methode (10)
- CRISPR/Cas9 (10)
- Cadherine (10)
- Calciumphosphate (10)
- Carbene (10)
- Children (10)
- Chronische Niereninsuffizienz (10)
- Churritisch (10)
- Cochlear-Implantat (10)
- Coronaviren (10)
- Covid-19 (10)
- Cyclo-GMP (10)
- Depressivität (10)
- Diamant (10)
- Digital Humanities (10)
- Dimerisierung (10)
- Dotierung (10)
- Echokardiographie (10)
- Eierstockkrebs (10)
- Elektrochemie (10)
- Elektronenkorrelation (10)
- Englisch (10)
- Enzyminhibitor (10)
- Erbkrankheit (10)
- Ereigniskorreliertes Potenzial (10)
- Erwachsener (10)
- Franken (10)
- Frau (10)
- Funktionalisierung <Chemie> (10)
- Funktionelle Kernspintomografie (10)
- Förderung (10)
- Geldpolitik (10)
- Glatter Krallenfrosch (10)
- Grenzfläche (10)
- HSM-Satztest (10)
- Herzmuskelzelle (10)
- Honigbiene (10)
- Hypophosphatasie (10)
- Immunology (10)
- Impfstoff (10)
- Induzierte pluripotente Stammzelle (10)
- Interleukin 4 (10)
- JNK (10)
- Klassifikation (10)
- Kniegelenk (10)
- Kohlenstoff (10)
- Komplikation (10)
- Kooperation (10)
- Kultur (10)
- LASP1 (10)
- LC-MS (10)
- Ladungstransfer (10)
- Ligand (10)
- Lokalisation (10)
- Magnesiumphosphate (10)
- Mathematikunterricht (10)
- Mathematisches Modell (10)
- Medulloblastom (10)
- Metakognition (10)
- Metallocene (10)
- Methylphenidat (10)
- Mikrokerne (10)
- Multiple Myeloma (10)
- Musik (10)
- Mutagenität (10)
- Nahrungserwerb (10)
- Nebennierenrindenkarzinom (10)
- Neolithikum (10)
- Neuropathischer Schmerz (10)
- Niger (10)
- Osteosynthese (10)
- Pain (10)
- Panikstörung (10)
- Parasit (10)
- Parodontitis (10)
- Pathogenität (10)
- Platelets (10)
- Plattenepithelkarzinom (10)
- Prevalence (10)
- Prostaglandine (10)
- Präfrontaler Cortex (10)
- Psychotherapie (10)
- Pädagogik (10)
- Qualitätskontrolle (10)
- RNA interference (10)
- RNA-seq (10)
- RNS-Spleißen (10)
- Radiotherapy (10)
- Remote Sensing (10)
- Rhodium (10)
- Rituximab (10)
- SAR (10)
- Schilddrüse (10)
- Silaanaloga (10)
- Silber (10)
- Silicon (10)
- South Africa (10)
- Sphingolipide (10)
- Sprachverstehen (10)
- Starke Kopplung (10)
- Stickstoffmonoxid-Synthase (10)
- Stressreaktion (10)
- Stroke (10)
- Struktur (10)
- T-Lymphozyten (10)
- T-Lymphozyten-Rezeptor (10)
- Tagesrhythmus (10)
- Theologie (10)
- Totalsynthese (10)
- Toxizität (10)
- Transplantat-Wirt-Reaktion (10)
- Transthorakale Echokardiographie (10)
- Treg (10)
- Trypanosomen (10)
- Verwaltungsrecht (10)
- Vitamin D (10)
- Vor- und Frühgeschichte (10)
- Vorschulkind (10)
- Wachstum (10)
- Zebrabärbling (10)
- amino acids (10)
- antimicrobial resistance (10)
- bariatric surgery (10)
- biosynthesis (10)
- boranes (10)
- chemokines (10)
- chronic heart failure (10)
- circadian rhythms (10)
- clinical trial (10)
- comparison (10)
- complex (10)
- coronary artery disease (10)
- decision-making (10)
- density functional calculations (10)
- eNOS (10)
- education (10)
- emotion regulation (10)
- fatigue (10)
- fear (10)
- genome-wide association (10)
- global change (10)
- hydrogels (10)
- immunomodulation (10)
- induced pluripotent stem cells (10)
- injury (10)
- insect (10)
- knockout (10)
- leaf-cutting ants (10)
- leukemia (10)
- lymph nodes (10)
- mapping (10)
- membrane potential (10)
- motivation (10)
- oncology (10)
- oncolytic virotherapy (10)
- oxidativer Stress (10)
- phenotype (10)
- quality assurance (10)
- regulatorische T-Zellen (10)
- remodeling (10)
- senescence (10)
- silicon (10)
- social interaction (10)
- stem cell transplantation (10)
- tDCS (10)
- tight junctions (10)
- tumors (10)
- vaccination (10)
- vertigo (10)
- water oxidation (10)
- Östrogene (10)
- 3 (9)
- Adenosin (9)
- Adenosine receptors (9)
- Affekt (9)
- Afrika (9)
- Alps (9)
- Analyse (9)
- Angeregter Zustand (9)
- Anxiety (9)
- Aorta (9)
- Aortenstenose (9)
- Bauchspeicheldrüsenkrebs (9)
- Beyond Standard Model (9)
- Biotransformation (9)
- Bordetella pertussis (9)
- Borylierung (9)
- Boğazkale (9)
- Butyrat (9)
- Carcinogenese (9)
- Catalysis (9)
- Chiralität <Chemie> (9)
- Cloud Computing (9)
- Computational chemistry (9)
- Deep learning (9)
- Dendritic cells (9)
- Diagnose (9)
- Diborane (9)
- Diskursanalyse (9)
- Dünndarm (9)
- Einzelphotonenemission (9)
- Elektroencephalographie (9)
- Elektronenmikroskopie (9)
- Elektronenstruktur (9)
- Elementarteilchenphysik (9)
- Epithel (9)
- Ernährung (9)
- Experimentelle Psychologie (9)
- Extremwertstatistik (9)
- Familie (9)
- Fanconi Anämie (9)
- Fettgewebe (9)
- Fibroblastenwachstumsfaktor (9)
- Fibromyalgie (9)
- Frühgeborene (9)
- GIS (9)
- Geistigbehindertenpädagogik (9)
- Gentherapie (9)
- Geoinformationssystem (9)
- Geruchswahrnehmung (9)
- Glioblastoma (9)
- Google Earth Engine (9)
- Grammatik (9)
- Handlungsorientierung (9)
- Haut (9)
- Herzmuskelkrankheit (9)
- Hethiter (9)
- Hyaluronsäure (9)
- IL-4 (9)
- Immunfluoreszenz (9)
- Immunisierung (9)
- Innovation (9)
- Instrumentelle Analytik (9)
- Integrine (9)
- Interview (9)
- Iran (9)
- Isolierung <Chemie> (9)
- Jugendliche (9)
- Kapillarelektrophorese (9)
- Knorpel (9)
- Kommunikation (9)
- Konflikt (9)
- Koordinationslehre (9)
- Korpus <Linguistik> (9)
- Landsat (9)
- Leber (9)
- Linguistik (9)
- Löslichkeit (9)
- MAPK (9)
- Macrophage (9)
- Magnetische Resonanz (9)
- Magnetismus (9)
- Mehrfachbindung (9)
- Mehrsprachigkeit (9)
- Messenger-RNS (9)
- Mice (9)
- Molekulare Erkennung (9)
- Monozyt (9)
- Morphologie (9)
- Mukoviszidose (9)
- Myokardprotektion (9)
- NAFLD (9)
- NO (9)
- Nebennierenrindenkrebs (9)
- Neuroinflammation (9)
- Nierentransplantation (9)
- Oberfläche (9)
- Oberflächenphysik (9)
- Optoelektronik (9)
- PD-1 (9)
- PD-L1 (9)
- Pathogenese (9)
- Persönlichkeit (9)
- Pharmakotherapie (9)
- Photolumineszenzspektroskopie (9)
- Physiologie (9)
- Plasmamembran (9)
- Protein (9)
- Pseudomonas syringae (9)
- Psychoonkologie (9)
- Quantenmechanik (9)
- Rechenzentrum (9)
- Rechtsvergleich (9)
- Regeneration (9)
- Regionalentwicklung (9)
- Revision (9)
- Sarkoidose (9)
- Satellit (9)
- Schmalwand <Arabidopsis> (9)
- Schwindel (9)
- Schüttgut (9)
- Sentinel-1 (9)
- Spin-Bahn-Wechselwirkung (9)
- Squaraine (9)
- Staphylococcus (9)
- Stathmin (9)
- Stereoselektive Synthese (9)
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- Syntax (9)
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- Textverstehen (9)
- Therapy (9)
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- Transplantat (9)
- Transport (9)
- Trypanosoma (9)
- Tumorantigen (9)
- Vakuole (9)
- Vergleich (9)
- Visuelle Aufmerksamkeit (9)
- Wurzel (9)
- X-ray crystallography (9)
- Zellkern (9)
- Zentralnervensystem (9)
- Zinkselenid (9)
- aggregation (9)
- agriculture (9)
- aldosterone (9)
- antennal lobe (9)
- anxiety disorders (9)
- aromaticity (9)
- bioinformatics (9)
- biomechanics (9)
- blood brain barrier (9)
- body size (9)
- bone cement (9)
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- cell culture (9)
- cell migration (9)
- cell wall (9)
- central nervous system (9)
- cerebrospinal fluid (9)
- chromatin (9)
- cognitive impairment (9)
- collagen (9)
- coronary heart disease (9)
- cuticular hydrocarbons (9)
- cystic fibrosis (9)
- decision making (9)
- dendritische Zellen (9)
- dialysis (9)
- dispersal (9)
- earth observation (9)
- electron microscopy (9)
- electronic properties and materials (9)
- electrophysiology (9)
- energy (9)
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- family (9)
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- gene therapy (9)
- glioma (9)
- glucose (9)
- high energy physics (9)
- hip (9)
- hyaluronic acid (9)
- hydrogel (9)
- impact (9)
- incidence (9)
- inhibitor (9)
- interferon (9)
- mechanotransduction (9)
- mesenchymale Stammzellen (9)
- metapopulation (9)
- methylation (9)
- mitosis (9)
- molecular biology (9)
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- monoklonale Antikörper (9)
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- pathway (9)
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- permeability (9)
- personality (9)
- platelet activation (9)
- platelet aggregation (9)
- prognostic factors (9)
- quantification (9)
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- reveals (9)
- serum (9)
- spinal muscular atrophy (9)
- synapse (9)
- systematic uncertainty (9)
- temperature (9)
- tolerance (9)
- transcription factor (9)
- transient absorption (9)
- transmission (9)
- type 2 diabetes (9)
- vaccine (9)
- walking (9)
- water (9)
- wound healing (9)
- Übersetzung (9)
- ATLAS (8)
- Adhärenz (8)
- Aggregat <Chemie> (8)
- Akt (8)
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- Aortenklappenersatz (8)
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- Arthroskopie (8)
- Arzneimittelforschung (8)
- Asymmetrie (8)
- Asymmetrische Synthese (8)
- Auge (8)
- Autoaggressionskrankheit (8)
- Autonomer Roboter (8)
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- Biradikal (8)
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- Blutdruck (8)
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- CD28 (8)
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- Caenorhabditis elegans (8)
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- DLBCL (8)
- Darm (8)
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- Datenbank (8)
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- Demenz (8)
- Deutschunterricht (8)
- Diborene (8)
- ERK (8)
- Elektronenspin (8)
- Elektronenspinresonanz (8)
- Emotionsregulation (8)
- Endothelzellen (8)
- Engagement (8)
- Erbrechen (8)
- Europa (8)
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- Femtosekundenbereich (8)
- Fibroblasten (8)
- Finite-Elemente-Methode (8)
- Fitness (8)
- Fluoreszenzspektroskopie (8)
- Forschung (8)
- Fußball (8)
- GABA (8)
- Gammastrahlung (8)
- Gedächtnisleistung (8)
- Geschlechtsunterschied (8)
- Gewebe (8)
- Gliom (8)
- Graphen (8)
- HPLC-MS (8)
- Habichtskraut (8)
- Haemophilus influenzae (8)
- Harnwegsinfektion (8)
- Hernie (8)
- Hochbegabung (8)
- Hubbard-Modell (8)
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- Hypertrophie (8)
- Hüftgelenk (8)
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- Immunantwort (8)
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- In vivo (8)
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- Kleinsatellit (8)
- Knockout (8)
- Komposit <Zahnmedizin> (8)
- Kondo-Effekt (8)
- Korrelation (8)
- Kreuzband (8)
- Kristallstruktur (8)
- LC-MS/MS (8)
- Landwirtschaft (8)
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- N-heterocyclic carbenes (8)
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- PONV (8)
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- Parton distributions (8)
- Pemphigus (8)
- Peptide (8)
- Periphere arterielle Verschlusskrankheit (8)
- Permeabilität (8)
- Pharmakodynamik (8)
- Photodissoziation (8)
- Photovoltaik (8)
- Platin (8)
- Pollen (8)
- Polycyclische Aromaten (8)
- Protein p53 (8)
- Protein-Tyrosin-Kinasen (8)
- Proteinbindung (8)
- Protonen-NMR-Spektroskopie (8)
- Präkonditionierung (8)
- Psychische Störung (8)
- Pump-Probe-Technik (8)
- Quantendynamik (8)
- Quelle (8)
- Quran (8)
- Radikal <Chemie> (8)
- Raf <Biochemie> (8)
- Raf-Kinasen (8)
- Raman spectroscopy (8)
- Rastertunnelmikroskop (8)
- Rechenzentrum Universität Würzburg (8)
- Regenerative Medizin (8)
- Rekombination (8)
- Retroviren (8)
- Ringöffnungspolymerisation (8)
- Roman (8)
- Röntgen-Photoelektronenspektroskopie (8)
- Salmonella typhimurium (8)
- Schmerzforschung (8)
- Schwämme (8)
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- Survival (8)
- Synthesis (8)
- T cell activation (8)
- T lymphocytes (8)
- T-Zelle (8)
- TDM (8)
- Tabak (8)
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- Thrombozyten (8)
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- Zahnmedizin (8)
- Zeitreihenanalyse (8)
- actin cytoskeleton (8)
- acute kidney injury (8)
- adherence (8)
- adolescence (8)
- allogeneic stem cell transplantation (8)
- amyotrophic lateral sclerosis (8)
- analysis of variance (8)
- animal models (8)
- antigen (8)
- astrocytes (8)
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- borylene (8)
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- cell biology (8)
- central complex (8)
- ceramide (8)
- charge transfer (8)
- chronic pain (8)
- classical conditioning (8)
- cleft lip and palate (8)
- coagulation (8)
- coherence (8)
- computed tomography (8)
- copper (8)
- cortisol (8)
- crystallization (8)
- cytotoxic T cells (8)
- decay (8)
- distribution (8)
- division of labor (8)
- domain (8)
- dystonia (8)
- electroencephalography (8)
- electronic structure (8)
- embodiment (8)
- endocytosis (8)
- extinction (8)
- flavonoids (8)
- foamy virus (8)
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- gephyrin (8)
- glycine receptor (8)
- health-related quality of life (8)
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- histology (8)
- immune evasion (8)
- implant (8)
- in vivo imaging (8)
- integrins (8)
- iron (8)
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- juvenile idiopathic arthritis (8)
- kinematic alignment (8)
- knee (8)
- latency (8)
- learning and memory (8)
- mHealth (8)
- macrophage (8)
- major depression (8)
- meta-analysis (8)
- methylphenidate (8)
- microenvironment (8)
- microstructure (8)
- monocyte (8)
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- kinase (7)
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- - (6)
- 18F-FDG (6)
- 2 (6)
- ABA (6)
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- AMPK (6)
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- ATLAS <Teilchendetektor> (6)
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- Theodor-Boveri-Institut für Biowissenschaften (2244)
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Schriftenreihe
- Cultural Animal Studies, Band 3 (24)
- Spezielle Didaktik der Sportarten (2)
- Aesthetische Eigenzeiten, 17 (1)
- Akten des ... Symposiums des Mediävistenverbandes; 13,2 (1)
- Alter Orient und Altes Testament : Sonderreihe Veröffentlichungen zur Kultur und Geschichte des Alten Orients ; 3 (1)
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- Deuterocanonical and Cognate Literature Yearbook (1)
- Epistemata. Reihe Literaturwissenschaft ; 483 (1)
Sonstige beteiligte Institutionen
- VolkswagenStiftung (24)
- Johns Hopkins School of Medicine (18)
- Fraunhofer-Institut für Silicatforschung ISC (8)
- IZKF Nachwuchsgruppe Geweberegeneration für muskuloskelettale Erkrankungen (7)
- Akademie der Wissenschaften und der Literatur, Mainz (6)
- DFG Forschungsgruppe 2757 / Lokale Selbstregelungen im Kontext schwacher Staatlichkeit in Antike und Moderne (LoSAM) (6)
- Clinical Trial Center (CTC) / Zentrale für Klinische Studien Würzburg (ZKSW) (5)
- Helmholtz Institute for RNA-based Infection Research (HIRI) (5)
- Johns Hopkins University School of Medicine (5)
- Universität Leipzig (5)
ResearcherID
- B-1911-2015 (1)
- B-4606-2017 (1)
- C-2593-2016 (1)
- D-1221-2009 (1)
- D-1250-2010 (1)
- D-3057-2014 (1)
- I-5818-2014 (1)
- J-8841-2015 (1)
- M-1240-2017 (1)
- N-2030-2015 (1)
No abstract available
Electron-opaque material is shown in the perinuclear cisternae of various cell types to connect the inner and outer nuclear membrane faces. Similar bridges were observed between the outer nuclear membrane and the outer mitochondrial membrane. The intracisternal bridges of the nuclear envelope appear to be important for the structural stability of the perinuclear cisterna. Stable structural linkage of mitochondria to the outer nuclear membrane might be relevant to the understanding of the characteristic juxtanuclear accumulation of mitochondria and also provide arguments for the discussions of certain biochemical activities found in nuclear and nuclear membrane fractions.
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Via reduction of benzvalene (1) with diirnine tricyclo[3.1.0.02•6]hexane is obtained in good yield. The procedure renders 3, which has already been synthesized by Lemal and Shim, accessible much easier and in larger quantities. IH and 13C n.m.r. spectroscopic data are discussed. Both the thermal and the AgBF4-catalyzed rearrangernent of 3 yield 1,3-cyclohexadiene (8). - The ozonolysis of 1 with subsequent LiAIH4-reduction results in cis-I,3- bis(hydroxyrnethyl)cyclobutane (13a).
Goldstandard in Nuzi
(1974)
Incubation of the colicinogenic Escherichia coli strain JC 411 (ColE1) at elevated temperatures (47-49°) leads to the accumulation of catenated molecules and replicative intermediates of this plasmid. Mature supercoiled OolE1 DNA molecules synthesized under these conditions have an increased number of tertiary turns as shown by electron microscopy. The monomeric tightly supercoiled molecules possess a slightly slower sedimentation rate and a higher binding capacity for ethidium bromide than supercoiJed monomers synthesized at lower temperatures. Recombination deficient mutants of E. coli recA, recB and recC, which carry the ColE1 plasmid, form about the same amount of catenated molecules at the elevated temperature as a rec+ strain. In addition, we have observed by electron microscopy a small percentage (.--.5% of the circular DNA molecules) of minicircular DNA molecules in all preparations of JC 411 (CoIE1). They are homogenous in size, with a molecular weight of 1.4 X 106 daltons. Addition of chloramphenicol to a culture of Proteus mirabilis (ColE1) leads to an increased amount of higher multiple circular oligomers and to a stimulated accumulation of catenated OolE1 DNA molecules of varying sizes. ColE1 DNA synthesis is more thermosensitive than chromosomal DNA replication in P. mirabili8. Plasmid replication stops completely at temperatures above 43°C.
Zum hurritischen Lexikon II
(1974)
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The structural organization of transcriptionally active DNA that contains cistrons for precursor molecules of ribosomal RNA is described in positively stained spread preparations from nuclei and nucleoli isolated from the green alga, Acetabularia mediterranea Lmx. These nuclei contain large aggregates of nucleolar subunits in which fibril-covered regions, the putative active cistrons for precursors of ribosomal RNA, alternate with fibril-free intercepts, the "spacers". The length distribution of the different intercepts of this DNA is given, and the pattern is compared with those shown in animal cell systems. The data are discussed in relation to problems of transcription and of amplification of ribosomal RNA genes.
The ultrastructure of th e growin g and ma turing primary nucleus of Acetabularia medite rranea and Acetabularia major has been studied with the use of various fi xation procedures. Particular interest has been focused on the deta ils of the nuclear periphery and the perinuclear region. It is demonstrated that early in nuclear grow th a characteristic perinucl ear structura l complex is formed which is, among the eukaryotic cells, unique to Acetabularia and re lated genera. This perinuclear system consists essentially of a) the nuclear envelope with a very hi gh pore frequency and various pore complex assoc iat ion s w ith granular and/or threadlike structures some of which are continuous with the nucleolus; b) an approx imate ly 100 nm thick intermediate zone densely filled with a filam entOus material and occasional sma ll membraneous structures from which the typical cytOplasmic and nuclear organe lles and particles are excl ud ed ; c) an adjacent Iacunar labyrinthum which is interrupted by many plasmatic junction channels between the intermed iate zone and the free cytOplasm; d) numerous dense perinuclear bodies in the juxtanuclear cytOplasm which a re especia lly frequent at the junction channels and reveal a composition of aggregated fibrillar and granul ar structures; e) very dense exclusively fibrill ar agg regates which occur either in assoc iation with t he perinuclear region of the lacunar labyrinthum or, somewhat further out, in the cytOplasmic strands between the bra nches of the lacun ar labyrinthum in the form of slender, characteristic rods or "sausages".
The present article had originally been conceived as a review on endomembranes, the plasma membrane, and the major product of membrane-bound activities, the cell wall material. However, limitations of space and the cascading number of pertinent literature articles made it necessary to confine this to one group of membranes and one type of cell wall components. Therefore, we shall begin our survey on the biochemical and cytological aspects of membranes by a review of the class of the pore complex bearing endomembranes, i.e. the nuclear envelope and the annulate lamellae (AL). Next year the membranes of the endoplasmic reticulum and the dictyosomes will be dealt with in conjunction with a discussion of the various intracellular vesicles, the tonoplast and the plasmalemma.
The preparation of Bi2Sea single crystals with low free carrier densities allowed an investigation of the lattice vibrations to be carried out from the reflectivity of cleavage planes at nearly normal incidence of the radiation (E ~ c). The experimental results ean be explained with two classical oscillators, whose eigenfrequencies oceur at 92 and 69.5 cm-I. The static dielectric constant was determined to be 100 ± 10 for E ~ c.
Primary (giant) nuclei of the green algae Acetabularia mediterranea and A. major were studied by light and electron microscopy using in situ fixed material as well as manually isolated nuclear components. In addition, cytochemical reactions of nuclear structures and biochemical determinations of nuclear and cytoplasmic RNA and of genome DNA content were performed. The data obtained and the structures observed are interpreted as demonstralions of transcriptional activities of different gene classes. The most prominent class is the nucleolar cistrons of precursors of ribosomal RNA which occur highly repeated in clusters in the form of regularly alternating intercepts on deoxyribonucleoprotein axes of transcribed rDNA, the fibril-covered matrix units, and the fibril-free "spacer" segments. A description and a classification of the various structural complexes which seem to represent transcriptional activities is given. Quantitative evaluations of these arrangements are presented. The morphology and the dimensions of such structures are compared with the RNA molecular weight determinations and with the corresponding data reported from various animal cell systems. It is suggested that the formation of the giant nucleus is correlated with, and probably due to, an enormous amplification of transcriptionally active rDNA and packing of the extrachromosomal copies into the large nucleolar aggregate bodies.
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Ausgehend von einigen Bedenken gegen die Verwendung von Wertungsfragen in der Soziometrie wird ein Verfahren vorgeschlagen, in dem konkretes Interaktionsverhalten (Sprechen und Ärgern) direkt skaliert wird. Der Zusammenhang zwischen direkter Skalierung, Bezugssystemtheorie und phänomenadäquater Verwendung von Skalen wird diskutiert. Jedes Gruppenmitglied (untersucht wurden Schulklassen) stuft seinen Kontakt zu jedem anderen ein. Daraus ergibt sich ein Sozioprofil, dessen Repräsentanz für das Sozialverhalten beispielhaft an Extremgruppen gezeigt wird. Es kann nachgewiesen werden, daß die bis jetzt unterstellte Trennung gemischtgeschlechtlicher Gruppen in zwei eingeschlechtliche Untergruppen ein methodenabhängiges Ergebnis der Wahlverfahren Morenoscher Prägung ist.
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Soluble mitochondrial ATPase (F1) isolated from Neurospora crassa is resolved by dodecylsulfate- gel electrophoresis into five polypeptide bands with apparent molecular weights of 59000, 55000, 36000, 15000 and 12000. At least nine further polypeptides remain associated with ATPase after disintegration of mitochondria with Triton X-100 as shown by the analysis of an immunoprecipitate obtained with antiserum to F 1 A TPase. Two of the associated polypeptides with apparent molecular weights of 19000 and 11000 are translated on mitochondrial ribosomes, as demonstrated by incorporation in vivo of radioactive leueine in the presence of specific inhibitors of mitochondrial (chloramphenicol) and extramitochondrial ( cycloheximide) protein synthesis. The appearance of mitochondrial translation products in the immunoprecipitated A TPase complex is inhibited by' cycloheximide. The same applies for some of the extramitochondrial translation products in the presence of chloramphenicol. This suggests that both types of polypeptides are necessary for the assembly of the A TPase complex.
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Sila-Analogues A 2, B 2 and C 2 of the drug mephenhydramine from the class of benzhydryl ethers were synthesized for the first time by the steps shown in scheme 1, and they and their precursors I-V characterized by their physical {table 1) and chemical properties, and their structures confirmed by NMR, n1ass and infrared spectroscopy (tables 3-5). Their physiological effects were investigated a.nd compared -with those of the parent carbon compounds (section 5).
Frühere Untersuchungen zum Entscheidungsverhalten von Kindern lassen zwei Interpretationen sogenannter lagebedingter Wahlen zu. Entscheidungen von 8- bis 14jährigen Schülern zeigten, daß sich lagebedingte Wahlen als orientiert am Erwartungsmaximum bezeichnen lassen. Die Beziehung zwischen Orientierung am Erwartungsmaximum und den Variablen Alter, Schulzugehörigkeit und Vorerfahrung erwies sich als positiv. Weiterhin konnte die Abhängigkeit der Wahlhäufigkeit des Erwartungsmaximums von der Hervorgehobenheit des Erwartungsmaximums nachgewiesen werden. Die Gültigkeit des objektiven Erwartungsmaximierungsmodells mußte aber wegen verschiedener Befunde eingeschränkt werden.
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Ziel der Untersuchung war, erste Informationen über die Verwendungsfähigkeit einer im amerikanischen Raum entwickelten Auswahlliste zur Messung des Spannungsbogens zu gewinnen. Dazu wurden mit 234 Jugendstrafgefangenen verschiedenen Alters die Verfahren Auswahlliste und Verhaltensprobe zur Erhebung des Spannungsbogens durchgeführt. Außerdem wurden Daten zum hypothetischen Sparverhalten der Vpn erhoben. Durch klassische und probabilistische Itemanalyse ergaben sich verschiedene Skalen aus der Auswahlliste, die alle in keiner Beziehung zum Alter und dem hypothetischen Sparverhalten standen. Verschiedene Nebenbefunde werden im Hinblick auf ihre Konsequenzen für die Verwendungsfähigkeit der Auswahlliste und auf Erklärungsmäglichkeiten diskutiert.
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Zur Abhängigkeit des Entscheidungsverhaltens lernbehinderter Sonderschüler von der Vorerfahrung
(1975)
Die Auswirkung einer Vorerfahrungsbedingung auf das Entscheidungsverhalten von Schülern wurde untersucht. 188 Volksund lernbehinderte Sonderschüler im Alter von 8 bis 14 Jahren wurden 15mal vor die Entscheidung gestellt, eine von drei Alternativen zu wählen. Die Wahlalternativen waren "Spiele gegen die Natur" mit den Konsequenzen" reale Gewinnauszahlung" und" Ausbleiben des Gewinns" .Als Lernbedingung dienten Spiele, bei denen das negative Ergebnis in dem realen Verlust eines Geldbetrages bestand. Es zeigten sich ein Anstieg von LageWahlen mit dem Alter und eine fördernde Wirkung der Lernbedingungbei Sonderschülern, die 12 Jahre alt oder älter waren. Außerdem ließen die Daten die Vermutung zu, daß das Ausmaß der Retardierung lernbehinderter Sonderschüler im Entscheidungsverhalten größer ist als in einem sprachfreien Intelligenztest.
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Rekonstitution des Chromophors und der Funktion von Bakteriorhodopsin aus Halobacterium halobium
(1976)
Ein Modell der lichtgetriebenen Protonenpumpe Bakteriorhodopsin postulierte die direkte Beteiligung der Wasserstoffe in der 4-Stellung des Cyclohexenringes des Retinalchromophors an dem Vorgang der Protonenverschiebung. Mittels Blockaden der Retroform-Bildung von Retinal durch chemische Modifizierungen des Cyclohexenringes (4-Hydroxy-Retinal, 5,6-Epoxy-Retinal) konnten nach Einbau der modifizierten Moleküle in die isolierte Purpurmembran und nach Zugabe zu Halobakterien mit unterdrückter Retinalsynthese die direkte Beteiligung des Cyclohexenringes an der Protonenpumpe mit großer Wahrscheinlichkeit ausgeschlossen werden.
No abstract available
Durch Umsetzungen von Alkalimetallcarbonaten mit Silber und Schwefel in der Schmelze wurden die ternären Sulfide K2Ag4S3 und Rb2Ag4S3 dargestellt. Röntgenographische Untersuchungen an Einkristallen führten zu einem neuen Schichtenstrukturtyp, in dem röhrenförmige Silber-Schwefel-Anordnungen mit nahezu trigonal planar von Schwefel koordinierten Silberatomen über gemeinsame S-Atome zu Schichten"verknüpft werden, zwischen denen die Alkalimetallatome eingelagert sind. Die monoklinen Elementarzellen enthalten vier Formeleinheiten. Die höchstsymmetrische Raumgruppe ist C2/m. Als Gitterkonstanten ergeben sich: K\(_2\)Ag\(_4\)S\(_3\): a = 17,36(1) A, b = 4,296(2) A, c = 11,603(5) A, B = 108,32(3t; Rb\(_2\)Ag\(_4\)S\(_3\): 80 = 17,88(1) A, b = 4,331(5) A, c = 11,849(5) A, B = 108,58(3)°.
No abstract available
Sila-ana.logues A 2 and B 2 of two drugs from the benzhydryl ether class, chlorphenoxamine and clofenetamine, were synthesized for the first time by the steps shown in scheme 1. They and their precursors I-VI v;rere characterized by their physical (Table 1) and chemical properties and their structures confirmed by n.m.r., mass and infrared spectroscopy (Tab]es 2-5). Their physiological effects were invest.igated and compared with those of the carbon analogues (Chapter 5).
Sila-analogues A 2, B 2 and C 2 of the drug mebrophenhydramine from the class of benzhydryl ethers -were synthesized for the first time by the steps shown in scheme 1, and they and their precurso:rs I-Ill were characterized by their physical (Table 1) and chemical properties, a.nd their structures confirmed by NMR, mass and infrared spectroscopy (Tables 3-5). The histaminolytic and anticholinergic effects of A 2 and C 2 were investigated and compared with some structure-activity relationships of analogue carbon compounds.
Sila-Analogues B 2 and A 2 of the spasmolytic ciclonium bromide (B 1) respectively the corresponding free base A 1 were synthesized for the first time according to the reaction steps sho·wn in scheme 1, and they and their precursors I and II were characterized by ph;ysical (Table 1} and chemical properties and their structures confirmed by NMR, and mass spectroscopy (Tables 2 and 3}. The pharmacological effects of A 2 and B 2 were investigated and compared with those of the parent carbon compound B 1 (chapter 5).
Derivatives A and B of the two sila-antihistam.ines silamephenhydramine and sila-chlorphenoxamine were synthesized for the first time by the steps shown in scheme 1. They and their precursors III and IV were characterized by their physical (Table 1) and chemical properties and their structures confirmed by NMR and mass spectroscopy (Tables 2 and 3). Their pharmacological effects were investigated and compared with those of the corresponding sila-antihistamines.
Isoelectronic derivatives (A and B) and a homolog (C) of the two sila-antihistamines sila-clofenetamine and silamebrophenhydramine were synthesized for the first time by the steps shown in scheme 1. They and their unknown precursors II-IV were characterized by their physical (Table 1) and chemical properties and their structures confinned by lH-NMR and rnass spectroscopy (Tables 2 and 3). The pharrnacological effects of A and B were investigated and compared with those of the corresponding 0-isosteric sila-antihistarnines (Chapter 5).
Jahresbericht 1975
(1976)
The arrangement of genes of precursor molecules for ribosomal RNA (pre-rRNA) in primary nuclei from two green algae species, Acetabularia mediterranea and A. major, has been analyzed in an electron microscope study. The pattern of transcriptional units in individual strands of nucleolar chromatin was investigated using spread and positively stained preparations. The rDNA pattern is not uniform but differs in different strands. The predominant type of nucleolar chromatin exhibits a high degree of homogeneity in the sequence of matrix units (intercepts covered with fibrilst hat contain the pre-rRNA) and fibril-free spacer intercepts. Substantial differences, however, are observed between the patterns in different strands. In addition, there is evidence in some strands for intraaxial heterogeneity of both spacer and matrix units. The following major types can be distinguished: type la, ca. 2 micrometer long matrix units, extremely short spacer intercepts in A. mediterranea (ca. 1 micrometer long ones in A. major), completely homogeneous distribution; type Ib, as type la but with intercalated, isolated, significantly shorter and/or longer matrix units; type lIa, matrix unit sizes as in type la, but much longer spacer intercepts, high degree of homogeneity; type Ill, largely heterogeneous arrangements of matrix and spacer units of varying sizes. The matrix unit data are compared with the sizes of pre-rRNA as determined by polyacrylamide gelelectrophoresis under denaturing and non-denaturing conditions. The findings are discussed in relation to recent observations in amphibia and insects and with respect to current concepts of the species-specificity of rDNA arrangements.
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The arrangement of transcriptional units in the loops of lampbrush chromosomes from oocyte nuclei of urodele amphibia and from primary nuclei of the green alga Acetabularia have been studied in the electron microscope using spread preparations. Loops with different patterns of arrangement of matrix units (i.e. to a first approximation, transcriptional units) can be distinguished: (i) loops consisting of one active transcriptional unit; (ii) loops containing one active transcriptional unit plus additional fibril-free, i.e. apparently untranscribed, intercepts that may include 'spacer' regions; (iii) loops containing two or more transcriptional units arranged in identical or changing polarities, with or without interspersed apparent spacer regions. Morphological details of the transcriptional complexes are described. The observations are not compatible with the concept that one loop reflects one and only one transcriptional unit but, rather, lead to a classification of loop types according to the arrangement of their transcriptional units. We propose that the lampbrush chromosome loop can represent a unit for the coordinate transcription of either one gene or a set of several (different) genes.
Natural changes in the transcription of rRNA genes were studied in nucleoli from three oogenic stages of the newt Triturus alpestris with electron microscope, autoradiographic, and biochemical techniques. From determinations of the uridine triphosphate pool sizes and [3H]uridine uptake, phosphorylation, and incorporation into 28S and 18S rRNAs in vivo it was estimated that the rate of rRNA synthesis was about 0.01% in previtellogenic oocytes and 13% in mature oocytes when compared to midvitellogenesis. Spread preparations of nucleoli showed significant morphological changes in the transcriptional complexes. The total number of lateral fibrils, i.e., ribonucleoproteins containing the nascent rRNA precursor, were drastically decreased in stages of reduced synthetic activity. This indicates that rRNA synthesis is regulated primarily at the level of transcription. The resulting patterns of fibril coverage of the nucleolar chromatin axes revealed a marked heterogeneity. On the same nucleolar axis occurred matrix units that were completely devoid of lateral fibrils, matrix units that were almost fully covered with lateral fibrils, and various forms of matrix units with a range of lateral fibril densities intermediate between the two extremes. Granular particles that were tentatively identified as RNA polymerase molecules were not restricted to the transcription l complexes. They were observed, although less regularly and separated by greater distances, in untranscribed spacer regions as well as in untranscribed gene intercepts. The results show that the pattern of transcriptional control of rRNA genes differs widely in different genes, even in the same genetic unit.
The disintegration of the nuclear envelope has been examined in nuclei and nuclear envelopes isolated from amphibian oocytes and rat liver tissue, using different electron microscope techniques (ultrathin sections and negatively or positively stained spread preparations). Various treatments were studied, including disruption by surface tension forces, very low salt concentrations, and non ionic detergents such as Triton X-lOO and Nonidet P-40. The high local stability of the cylinders of nonmembranous pore complex material is emphasized. As progressive disintegration occurred in the membrane regions, a network of fibrils became apparent which interconnects the pore complexes and is distinguished from the pore complexassociated intranuclear fibrils. This network might correspond to an indistinct lamella, about 15 - 20 nm thick, located at the level of the inner nuclear membrane, which is recognized in thin sections to bridge the interpore distances. With all disintegration treatments a somewhat higher susceptibility of the outer nuclear membrane is notable, but a selective removal does not take place. Final stages of disintegration are generally characterized by the absence of identifiable, membrane- like structures. Analysis of detergent-treated nuclei and nuclear membrane fractions shows almost complete absence of lipid components but retention of significant amount of glycoproteins with a typical endomembrane-type carbohydrate pattern. Various alternative interpretations of these observations are discussed. From the present observations and those of Aaronson and Blobel (1,2), we favor the notion that threadlike intrinsic membrane components are stabilized by their attachment to the pore complexes, and perhaps also to peripheral nuclear structures, and constitute a detergent-resistant, interpore skeleton meshwork.
Several types of "irregular" structures in the arrangement of lateral fibrils were noted in electron microscopic preparations of transcriptionally active nucleolar chromatin from various plant and animal cells. Such forms include: I. Disproportionately long lateral fibrils which occur either as individual fibrils or in groups; 2. "Prelude complexes" and other arrangements of lateral fibrils in apparent spacer intercepts; 3. Thickening of the rDNA chromatin axis at the starting end of pre-rRNA matrix units; 4. Extremely long matrix units , the length of which exceeds that of the rDNA (double-strand) sequence complementary to the specific pre-rRN A (for abbreviations see text). In addition, the stability of high molecular weight RNAs contained in the nucleolar ribonucleoproteins during the preparation for electron microscopy was demonstrated by gel electrophoresis. The observations indicate that the morphological starting point of a pre-rRNA matrix unit is not necessarily identical with the initiation site for synthesis of pre-rRNA, but they rather suggest that the start of the transcriptional unit is located at least O.2-D.8 JLm before the matrix unit and that parts of the "apparent spacer" are transcribed. It is proposed that the pre-rRN A molecules do not represent the primary product of rDNA transcription but rather relatively stable intermediate products that have already been processed during transcription.
On the existence of arrested transcriptional machinery in late stages of avian erythropoiesis
(1976)
No abstract available
The photoconductivity of both undeformed and deformed Te samples has been investigated at liquid He temperature by means of a Fourier spectrometer. Three peaks were usually found in the spectra of undeformed samples at 11, 24 and 46 cm\(^{-1}\). These are shown to be due to three different chemical impurities. The deformed samples are characterized by additional structure at higher frequencies.
The ultrastructure of twO kinds of transcription ally active chromatin, the lampbrush chromosome loops and the nucleoli from amphibian oocytes and primary nuclei of the green alga Acetabularia, has been examined after manual isolation and dispersion in low salt media of slightly alkaline pH using various electron microscopic staining techniques (positive staining, metal shadowing, negative staining, preparation on positively charged films, etc.) and compared with the appearance of chromatin from various somatic cells (hen erythrocytes, rat hepatocytes, ClIltured murine sarcoma cells) prepared in parallel. While typical nucleosomes were revealed with all the techniques for chromatin from the latter three cell system, no nucleosomes were identified in either the lampbrush chromosome structures or the nucleolar chromatin. Nucleosomal arrays were absent not only in maximally fibril-covered matrix units but also in fibril-free regions between transcriptional complexes, including the apparent spacer intercepts between different transcriptional units. Moreover, comparisons of the length of the repeating units of rDNA in the transcribed state with those determined in the isolated rDNA and with the lengths of the first stable product of rDNA transcription, the pre-rRNA, demonstrated that the transcribed rDNA was not significantly shortened and/or condensed but rather extended in the transcriptional units. Distinct granules of about nucleosomal size which were sometimes found in apparent spacer regions as well as within matrix units of reduced fibril density were shown not to represent nucleosomes since their number per spacer unit was not inversely correlated with the length of the specific unit and also on the basis of their resistance to treatment with the detergent Sarkosyl NL-30. It is possible to structurally distinguish between transcriptionally active chromatin in which the DNA is extended in a non-nucleosomal form of chromatin and condensed, inactive chromatin within the typical nucleosomal package. The characteristic extended structure of transcriptionally active chromatin is found not only in the transcribed genes but also in non-transcribed regions within or between ("spacer") transcriptional units as well as in transcriptional units that are untranscribed amidst transcribed ones and/or have been inactivated for relatively short time. It is hypothesized that activation of transcription involves a transition from a nucleosomal to an extended chromatin organisation and that this structural transition is not specific for single "activated" genes but may involve larger chromatin regions, including adjacent untranscribed intercepts.
No abstract available
Von Aussagen von Vpn ausgehend wird eine Erklärung für die Nichtanwendung der Erwartungsmaximierung in Entscheidungen zwischen Spielen gegen die Natur gegeben, die in einer Untersuchung empirisch bestätigt wurde. Danach hängt die Verwendung der Erwartungsmaximierung von situationalen Bedingungen ab, die den Vpn eine Anwendung des Wahrscheinlichkeitsbegriffs für eine Menge gleichartiger Zufalls experimente nahelegen. Der Befund der Untersuchung kann auch durch die PortfolioTheorie erklärt werden. Zur Beseitigung dieses Dilemmas wird auf die Introspektion zurückgegriffen.
No abstract available
Durch BeDbachtungen und Beurteilungen wurde die Durchführbarkeit und Wirksamkeit einer MethDde zur Beeinflussung der Behandlungsbereitschaft bei 30 jugendlichen Strafgefangenen unter zwei VDllzugsbedingungen geprüft. Die MethDde erwies sich bei dieser Stichprobe als durchführbar und erschien darüber hinaus allenfalls in der Anfangsphase geeignet, therapeutische KDntakte bei Therapieunwilligen anzubahnen. Milieutherapeutische Bedingungen im StrafvDllzug waren förderlich für die anfangs auftretenden pO'sitiven Effekte.
In Fragebögen tauchen häufig ternäre Antwortmöglichkeiten auf (z.B. ja - nein - weiß nicht). Für eine Analyse solcher Hems werden Kennwerte vorgeschlagen. Dabei wird ein der Schwierigkeit analoger Popularitätsindex eingeführt, der in p+ den Anteil der Ja-Antworten angibt. Aus p+ und p-, dem Anteil der Nein-Antworten, wird ein Aktualitätsindex definiert, der in den Grenzen zwischen 0 und 1 variiert und die Eliminierung wenig aktueller Fragen gestattet. Zur Bestimmung der Trennschärfe werden Punkt-Vierfelder- oder phi-Koeffizienten angegeben. die aus der Zerlegung des X2 einer 3x2-Tafel in eine 2x2-Tafel und in eine auf die Unbestimmtheitsantwort zurückgehende Restkomponente entstehen. Ebenso werden Koeffizienten für Iteminterkorrelationen aus 3x3-Tafeln und Indizes für die Reliabilität angegeben.
Es wird ein neues soziometrisches Verfahren vorgeschlagen, das in seiner Grundlegung von heute üblichen Wahlverfahren abweicht. Dabei wird versucht, in einem ersten Teil die Gedanken darzustellen, die zur Formulierung der soziometrischen Fragen geführt haben. Im zweiten Teil wird der Gang der Auswertung dargestellt, der ein differenziertes Bild der untersuchten Personen zeichnen soll. Im Teil "Ergebnisse" wird am Beispiel von Extremgruppen gezeigt, was die Methode leisten kann. Schließlich werden noch mögliche Modifikationen des Verfahrens aufgezeigt.
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KCu\(_3\)S\(_2\) kann auf dem gleichen Wege synthetisiert werden, auf dem auch verschiedene Alkalithioargentate zu erhalten sind 1,2: Das Münzmetall wird im Gemenge mit einem Überschuß von Alkalicarbonat und Schwefel etwa 1 h im Argonstrom auf 850°C erhitzt. Den erkalteten Schmelzkuchen zieht man mit Wasser aus. Die wasserunlöslichen Kristalle werden mit Wasser, Alkohol und Äther gewaschen und im Vakuum getrocknet. Bei Reaktionstemperaturen von 780-850 °C fällt KCu\(_3\)S\(_2\) in Form von schwarzen glänzenden Nadeln an. Bei niedrigeren Temperaturen entstehen die schon von W. RüDORFF3 beschriebenen Verbindungen K\(_3\)Cu\(_8\)S\(_6\) und KCu\(_4\)S\(_3\), die wir hier an Hand ihrer bekannten Pulverdiagramme identifizieren konnten.
No abstract available
Es wird ein konfigural-analytisches Verfahren zur Erfassung von fünf Variablen der Therapiemotivation (Leidensdruck, Unzufriedenheit, Änderungswunsch, Hilfewunsch und Erfolgserwartung) beschrieben. Die Methode besteht aus einer Kombination der Auswahl zutreffender Selbstbeschreibungen ("Probleme") und der Beantwortung motivationsbezogener Zusatzfragen. Jeder Pb wird so zu seinen spezifischen Problemen hinsichtlich der Ausprägung therapierelevanter motivationaler Variablen befragt. Aus der Beantwortung der Zusatzfragen können verschiedene Therapiemotivations- Syndrome (TMS) gebildet werden. Die statistische Absicherung des individuellen Vorkommens eines TMS in den Zusatzbefragungen erfolgt über die Multinominalverteilung. Dabei wird von der Häufigkeit ausgewählter Probleme eines Pb abstrahiert. Die Erprobung des Verfahrens wurde an 211 Inhaftierten einer Jugendstrafanstalt als potentieller Klienten-Population vorgenommen. Als Kontrollgruppe dienten 207 Berufsschüler vergleichbaren Alters. Während bei den Berufsschülern die Häufigkeit bei der Klassifikation in verschiedene TMS-Gruppen immer im zufälligen Bereich lagen, konnten bei den Delinquenten überzufällig häufig besetzte Gruppenstärken gefunden werden. In der Diskussion wurde auf den Unterschied des hier benutzten Klassifikationsverfahrens zur Konfigurations-Frequenzanalyse und zu Maßen Externaler-Internaler-Kontrolle eingegangen. Außerdem wurden Implikationen der Diagnose von Klienten-Therapiemotivation ftir die Entwicklung therapeutischer Verfahren aufgezeigt.