Filtern
Volltext vorhanden
- ja (650)
Erscheinungsjahr
- 2020 (650) (entfernen)
Dokumenttyp
- Artikel / Aufsatz in einer Zeitschrift (650) (entfernen)
Sprache
- Englisch (613)
- Deutsch (35)
- Französisch (1)
- Mehrsprachig (1)
Schlagworte
- boron (9)
- multiple myeloma (9)
- machine learning (8)
- COVID-19 (7)
- autophagy (6)
- biodiversity (6)
- cancer (6)
- depression (6)
- inflammation (6)
- toxicity (6)
- ADHD (5)
- adrenocortical carcinoma (5)
- biomarker (5)
- evolution (5)
- osteoporosis (5)
- pain (5)
- relapse (5)
- stem cells (5)
- therapy (5)
- 3D printing (4)
- CXCR4 (4)
- Fabry disease (4)
- Merkel cell carcinoma (4)
- SARS-CoV-2 (4)
- anxiety (4)
- artificial intelligence (4)
- binding (4)
- brain (4)
- cardiorespiratory fitness (4)
- diversity (4)
- fluorescence (4)
- heart failure (4)
- hypophosphatasia (4)
- immunotherapy (4)
- luminescence (4)
- mHealth (4)
- melanoma (4)
- mitochondria (4)
- molecular docking (4)
- mortality (4)
- mouse (4)
- multiple sclerosis (4)
- neural networks (4)
- osteoarthritis (4)
- remote sensing (4)
- self-assembly (4)
- structure elucidation (4)
- technology (4)
- transplantation (4)
- wearable (4)
- Apis mellifera (3)
- B cells (3)
- Bor (3)
- DNA damage (3)
- LASP1 (3)
- Parkinson’s disease (3)
- additive manufacturing (3)
- aggregation (3)
- aging (3)
- antibiotics (3)
- biofabrication (3)
- bone (3)
- boronate esters (3)
- borylation (3)
- breast cancer (3)
- chemistry (3)
- children (3)
- chondrocytes (3)
- climate change (3)
- database (3)
- deep learning (3)
- dental education (3)
- diagnosis (3)
- diborenes (3)
- endurance (3)
- energy (3)
- expression (3)
- foraging (3)
- forest (3)
- forest management (3)
- heterocycles (3)
- human (3)
- hypoxia (3)
- identification (3)
- immune response (3)
- in vitro selection (3)
- innovation (3)
- liquid crystals (3)
- magnetic resonance imaging (3)
- management (3)
- melt electrowriting (3)
- mesenchymal stem cells (3)
- microbiome (3)
- mutualism (3)
- myelin (3)
- nutrition (3)
- polygenic risk score (3)
- prediction (3)
- prevalence (3)
- random forest (3)
- recognition (3)
- recurrence (3)
- refractory (3)
- stroke (3)
- thermodynamics (3)
- time series (3)
- tinnitus (3)
- tumor microenvironment (3)
- 18F-FDG PET/CT (2)
- ACID (2)
- AI (2)
- Acromyrmex fracticornis (2)
- Bone marrow (2)
- CML (2)
- CNN (2)
- DNA double-strand breaks (2)
- ECM (2)
- Earth Observation (2)
- Earth observation (2)
- Epichloë (2)
- Expansion microscopy (2)
- Fake News (2)
- GLUT2 (2)
- GLUT3 (2)
- Germany (2)
- Grundschule (2)
- HGF (2)
- HNSCC (2)
- Heterocyclen (2)
- Hill numbers (2)
- LC-HRESIMS (2)
- Landsat (2)
- Lolium perenne (2)
- MPS1 (2)
- Medienkompetenz (2)
- Medienkritik (2)
- Met (2)
- Metastatic breast cancer (2)
- Microglia (2)
- NMR spectroscopy (2)
- PET (2)
- PSMA (2)
- Pakistan (2)
- Propaganda (2)
- RNA modification (2)
- RNA-seq (2)
- SAR (2)
- SGLT1 (2)
- Staphylococcus aureus (2)
- Surgery (2)
- UAV (2)
- Western diet (2)
- aggression (2)
- amyotrophic lateral sclerosis (2)
- angiogenesis (2)
- antibiotic (2)
- antimicrobial (2)
- association (2)
- astrocytoma (2)
- atopic dermatitis (2)
- attention (2)
- autoantibodies (2)
- autoimmunity (2)
- autonomic nervous system (2)
- bee decline (2)
- bees (2)
- biofilm (2)
- bioprinting (2)
- bipolar disorder (2)
- biradicals (2)
- bismuth (2)
- body size (2)
- bone remodeling (2)
- brain pathology (2)
- brain stem (2)
- carbenes (2)
- cardiomyopathy (2)
- cartilage (2)
- case report (2)
- catalysis (2)
- catecholamines (2)
- cations (2)
- cell death (2)
- circadian clock (2)
- circular dichroism (2)
- clinical practice (2)
- colorectal cancer (2)
- convolutional neural networks (2)
- corannulene (2)
- coronavirus (2)
- cortisol (2)
- criteria (2)
- crowdsensing (2)
- crowdsourcing (2)
- crystal structure (2)
- cytotoxic activity (2)
- data visualization (2)
- deadwood enrichment (2)
- detrended fluctuation analysis (2)
- development (2)
- diabetes (2)
- diffusion tensor imaging (2)
- dispersal (2)
- docking (2)
- dopamine (2)
- dosimetry (2)
- drug adverse reaction (2)
- drug allergy (2)
- drug hypersensitivity (2)
- eHealth (2)
- earth observation (2)
- echocardiography (2)
- economic growth (2)
- endophyte (2)
- endurance exercise (2)
- entropy production (2)
- enzyme replacement therapy (2)
- exercise (2)
- exome sequencing (2)
- exposure (2)
- extracellular matrix (2)
- extracellular vesicles (2)
- fibromyalgia syndrome (2)
- fixation (2)
- fluorescent probes (2)
- fluorine (2)
- gait initiation (2)
- galactomannan (2)
- gender stereotypes (2)
- gene expression (2)
- gestaltungsorientierte Bildungsforschung (2)
- glial fate modulation (2)
- glioblastoma multiforme (2)
- glucose transporter (2)
- handlungs- und entwicklungsorientierte Didaktik (2)
- head and neck cancer (2)
- hiPSC (2)
- hydrogels (2)
- hyperactivity (2)
- image segmentation (2)
- immunohistochemistry (2)
- impulsivity (2)
- in vitro (2)
- in vivo (2)
- invasion (2)
- invasive aspergillosis (2)
- iron deficiency (2)
- ischemic stroke (2)
- kinetics (2)
- land cover (2)
- land use (2)
- leaf-cutting ants (2)
- locomotion (2)
- low-grade glioma (2)
- lung injury (2)
- main group elements (2)
- marine natural products (2)
- mechanisms (2)
- mechanotransduction (2)
- miRNA (2)
- migrants (2)
- migration (2)
- molecular dynamics (2)
- monitoring (2)
- movement ecology (2)
- multiple linear regression (2)
- myofibrillar myopathy (2)
- nanoparticles (2)
- natural disturbance (2)
- neurology (2)
- neuroprotection (2)
- noncovalent interactions (2)
- norepinephrine (2)
- object detection (2)
- oncology (2)
- organoids (2)
- patient blood management (2)
- periodontitis (2)
- phenology (2)
- photocatalysis (2)
- physical activity (2)
- plant-insect interactions (2)
- platelet (2)
- preterm infant (2)
- printed tooth (2)
- prodrug (2)
- progression (2)
- prostate cancer (2)
- proteomics (2)
- quality (2)
- quality assurance (2)
- quality of life (2)
- quantification (2)
- radiation (2)
- radiotherapy (2)
- reactive oxygen species (2)
- redox (2)
- refugees (2)
- repair (2)
- replication (2)
- resistance (2)
- review (2)
- rhodesain (2)
- safety (2)
- saproxylic beetles (2)
- sarcopenia (2)
- seasonality (2)
- secretion (2)
- selection (2)
- self-adaptive systems (2)
- self-aware computing (2)
- self-organization (2)
- sequence (2)
- sex (2)
- smartwatch (2)
- solitary bee (2)
- stimulation (2)
- student training (2)
- supramolecular chemistry (2)
- surgery (2)
- survival (2)
- symbiosis (2)
- systematic review (2)
- titanium (2)
- tool use (2)
- transactivation (2)
- transcriptional regulation (2)
- transcriptome (2)
- urticaria (2)
- vancomycin (2)
- vitamin D (2)
- wood-inhabiting fungi (2)
- xenotransplantation (2)
- zebrafish (2)
- π-conjugated systems (2)
- (auto)biographical writing (1)
- (cardiac) surgery (1)
- 1,4-naphthoquinone (1)
- 11C-Methionine PET/CT (1)
- 21q22.2-q22.3 (1)
- 28 (1)
- 3D Printing (1)
- 3D culture (1)
- 3D electrophysiology (1)
- 3D neuronal networks (1)
- 3D reconstruction (1)
- 3D scaffolds (1)
- 3D tissue models (1)
- 4D-MRI (1)
- 53BP1 (1)
- 6-benzylaminopurine (1)
- 68Ga-PSMA ligand PET/CT (1)
- 68Ga-Pentixafor PET/CT (1)
- 8-oxoguanine (1)
- A20 (1)
- ACPC (1)
- ADAM9 (1)
- ADME analysis (1)
- AKT-signaling (1)
- AKT1 (1)
- ALPL (1)
- ALS mimic (1)
- ALiOS (1)
- AO (1)
- ARDS (acute respiratory distress syndrome) (1)
- ASE formula (1)
- ATG proteins (1)
- ATG12-ATG5 conjugate (1)
- ATP-adenosine triphosphate (1)
- Abdominaltrauma (1)
- Academic libraries (1)
- Acene (1)
- Acer platanoides (1)
- Acipenser baerii (1)
- AcrAB-TolC efflux pump (1)
- Actinoide (1)
- Acute lymphocytic leukaemia (1)
- Adaptive cell transfer (1)
- Adenovirus (1)
- African sleeping sickness (1)
- Agalsidase beta (1)
- Akt (1)
- Aldehyde Complexes (1)
- Alps (1)
- Alzheimer's disease (1)
- Alzheimers disease (1)
- Alzheimer’s disease (1)
- Alzheimer′s disease (1)
- Amplitude (1)
- Amrum (1)
- Anatomic reattachment (1)
- Animal Tracking (1)
- Animal behavior (1)
- Antarctic ice sheet (1)
- Antarctica (1)
- Anterior chamber perfusion model (1)
- Anthropocene (1)
- Anti-tank rocket (1)
- Anti-tank weapon (1)
- Antiviral nucleoside analogues (1)
- Any Evil (1)
- Arrhenius equation (1)
- Art (1)
- Arthrography (1)
- Aspergillus fumigatus (1)
- Aspergillus medium (1)
- Aspergillus sp. (1)
- Asteraceae (1)
- Attitude (1)
- Autologous hematopoietic stem cell transplantation (1)
- Automated analysis (1)
- Außerklinischer Herz-Kreislauf-Stillstand (1)
- Axl tyrosine kinase (1)
- Axon degeneration (1)
- Aššur (1)
- B cell (1)
- B,N-heterocycles (1)
- BARF-mutated melanoma (1)
- BCR‐ABL (1)
- BDG (1)
- BDNF (1)
- BK channel (1)
- BP180 (1)
- BPD (1)
- BRAF (1)
- BRAF mutation (1)
- BTN (1)
- BTN2 (1)
- BTN3 (1)
- Babylon (1)
- Bacillus (1)
- Ballistics (1)
- Barth syndrome (1)
- Bavaria (1)
- Beckenfraktur (1)
- Beckenring (1)
- Beer, Johann / Der symplicianische Welt-Kucker oder abentheuerliche Jan Rebhu (1)
- Belgium (1)
- Beliefs (1)
- Bembix (1)
- Bewältigungsfähigkeiten (1)
- Bibel <Psalmen> (1)
- Bienenverhalten (1)
- Bindungsaktivierung (1)
- Bindungsverhältnisse (1)
- Biostratigraphy (1)
- Biradikale (1)
- Blood–brain barrier (1)
- Bordetella pertussis (1)
- Boron (1)
- Boronatester (1)
- Borylene (1)
- Borylierung (1)
- Brevier (1)
- Brownian ratchet (1)
- Bull-Headed Demon (1)
- C-reactive protein (1)
- C-tactile fibers (1)
- C. elegans (1)
- CAD (1)
- CAM (1)
- CAR T cell (1)
- CAR T cells (1)
- CBT (1)
- CCL3 (1)
- CCL4 (1)
- CCL5 (1)
- CCS (1)
- CCl\(_4\) (1)
- CD10 (1)
- CD2AP (1)
- CD38 (1)
- CD8\(^+\) T cells (1)
- CDC14A (1)
- CIB1 (1)
- CIT (1)
- CLV3p (1)
- CMV reactivation (1)
- CNS disease (1)
- CORONATINE INSENSITIVE 1 (1)
- COVID 19 (1)
- COVID-19 Pandemie (1)
- COX2 expression (1)
- CRISPR-Cas system (1)
- CT (1)
- CVID (1)
- CX3CL1 (1)
- CXCL13 (1)
- CXCR7 (1)
- CYP2B6 (1)
- CYP2W1 (1)
- Ca cycling (1)
- Cambrian (1)
- Cancellous bone (1)
- Candida albicans (1)
- Candida auris (1)
- Candida lusitaniae (1)
- Candida sp. (1)
- Carbokationen (1)
- CardioMEMS™ HF system (1)
- Cardiomyopathy (1)
- Career choice (1)
- Carpinus betulus (1)
- Cartilage (1)
- Cartilage regeneration (1)
- Case report (1)
- Cataglyphis-Wüstenameisen (1)
- Cdu1 (1)
- Cecropia telenitida (1)
- Chagas diagnosis (1)
- Chagas disease (1)
- Chagas monitoring (1)
- Chagas real time PCR (1)
- Charcot–Marie–Tooth disease type 1A (1)
- Chemie (1)
- Chimeric Antigen Receptor T cells (1)
- ChlaDUB1 (1)
- Chlamydia trachomatis (1)
- Chondrogenesis (1)
- Christianity (1)
- Chrysididae (1)
- Colonial memory (1)
- Complex medium (1)
- Computer science (1)
- Concealed Information Test (1)
- Cone-beam computed tomography (1)
- Coronavirus (1)
- Coronavirus Disease 2019 (1)
- Costa Rica (1)
- Counter-Narrative (1)
- Covid-19 (1)
- CubeSat (1)
- CyaA (1)
- Cyclopenten-4-yl-Kation (1)
- DFNB32 (1)
- DFT-Rechnungen (1)
- DNA barcoding (1)
- DNA catalysis (1)
- DNA damage response (1)
- DNA metabarcoding (1)
- DNA structures (1)
- DR Congo (1)
- DUB (1)
- DYT1 (1)
- Damage control surgery (1)
- Davis gun (1)
- Deoxyribozyme (1)
- Deoxyribozymes (1)
- Design patterns (1)
- Diagnose (1)
- Dialogue Board (1)
- Diboran (1)
- Diboren (1)
- Diborierung (1)
- Digitalisierung (1)
- Diktat (1)
- Dilated Cardiomyopathy with Ataxia (1)
- Dioscorea (1)
- Disaster response (1)
- Distal biceps tendon repair (1)
- Distal outflow trac (1)
- Doctor (1)
- Dongting Lake (1)
- Donor lymphocytes (1)
- Donor−acceptor dyads (1)
- Drosophila melanogaster (1)
- E3 enzyme (1)
- EAHP/SH bone marrow workshop (1)
- EDA-NOCV (1)
- EGFR (1)
- EGR1 (1)
- EPR (1)
- EPR spectroscopy (1)
- ER signaling (1)
- EULAR guidelines (1)
- EVs (1)
- Einstellung zum Tod (1)
- El Escorial (1)
- Elbow (1)
- Elbow joint (1)
- Elderly patients (1)
- Emotionsregulierung (1)
- English version (1)
- Enzyme replacement therapy (1)
- Epichloë spp. (1)
- Epigenetik (1)
- Epitranscriptomics (1)
- Eriodictyon californicum (1)
- Ernaux, Annie (1)
- Escape Game (1)
- Escape Room (1)
- Escape game (1)
- Euler system (1)
- Euler–Bernoulli damped beam (1)
- Evaluation (1)
- Expected MOS (1)
- Expected QoE (1)
- Extrakorporale Membranoxygenierung (1)
- F-18-FDG PET (1)
- FRN (1)
- FSHD (1)
- Fabry genotype (1)
- Fabry phenotype (1)
- Fabry-associated pain (1)
- Fagus orientalis (1)
- Fagus sylvatica (1)
- Familiensprachen (1)
- Family languages (1)
- Fear (1)
- Federico García Lorca (1)
- Feedback (1)
- Fehleridentifikation (1)
- Female patients (1)
- Feminisation (1)
- Feministische Friedensforschung (1)
- Ferrante, Elena (1)
- Festkörperstrukturen (1)
- FinO family (1)
- Fixation (1)
- Flanders (1)
- Flavonoids (1)
- Fluoreszenzresonanz-Energietransfer (1)
- Fokker–Planck equation (1)
- Forensische Anthropologie (1)
- Forensische Osteologie (1)
- Fourthcorner analysis (1)
- Foxp3 (1)
- Fraser syndrome (1)
- Fraxinus excelsior (1)
- Freud (1)
- Functional nucleic acids (1)
- G protein coupled receptor (GPCR) (1)
- G-protein coupled receptor (1)
- G-quadruplexes (1)
- GHQ-28 (1)
- GLUT1 (1)
- GLUT4 (1)
- GLUT5 (1)
- GLUTs (1)
- GM (1)
- GNA11 (1)
- GNAQ (1)
- GNSS/INS integrated navigation (1)
- GSK-3β (1)
- Ga-68 (1)
- Gallium (1)
- Gaming (1)
- Gender (1)
- Gene expression vectors (1)
- Gene therapy (1)
- Genetik (1)
- Geschichte 1479-1575 (1)
- Geschlechterstereotype (1)
- Geschlechtsbestimmung (1)
- Gesundheits-App (1)
- Ghana (1)
- Giant cell arteritis (GCA (1)
- GlobALS (1)
- Globale Fürsorge (1)
- Glucose transport (1)
- Golgi (1)
- Good-or-Better (GoB) (1)
- Gram-positive bacteria (1)
- Green’s functions (1)
- Grimmelshausen, Hans Jakob Christoffel von / Continuatio des abentheurlichen Simplicissimi oder der Schluß desselben (1)
- Guillain-Barre-Syndrome (1)
- HB-EGF (1)
- HFQ (1)
- HIV-1 (1)
- HMDP hydroxymethylene diphosphonate (1)
- HPLC/UPLC methods (1)
- HPLC–MS (1)
- HPP (1)
- HRV (1)
- HSAB principle (1)
- Habichtskraut (1)
- Hadron-Hadron scattering (experiments) (1)
- Hahnenfuß (1)
- Halogene (1)
- Halogenierung (1)
- Health care service research (1)
- Heart rate (1)
- Heterocycles (1)
- Hieracium (1)
- High-throughput data (1)
- Himmelskompass (1)
- Hip joint (1)
- Hippo signaling (1)
- Holothuria spinifera (1)
- Hospital emergency plan (1)
- Hydroborierung (1)
- Hyperkonjugation (1)
- Hypertrophy (1)
- IA (1)
- ICP27 (1)
- IL-1ß (1)
- IL-22 binding protein isoform (1)
- IL-4 (1)
- IL22RA2 (1)
- IL‐1β (1)
- INS/LIDAR integrated navigation (1)
- IR spectroscopy (1)
- Identifizierung (1)
- IgE (1)
- IgG glycosylation (1)
- Image processing (1)
- ImageJ plugin (1)
- Imaging (1)
- Immunotherapy (1)
- In vitro models (1)
- In vivo studies (1)
- Infectious complications (1)
- Innovation (1)
- Inoculum production (1)
- Insect symbiois (1)
- Insektennavigation (1)
- Instructors (1)
- Internet of Things (1)
- Interview (1)
- Intrakranielle Blutung (1)
- IoT (1)
- Ionizing radiation (1)
- Islam (1)
- Isomorphe Nukleobasen-Analoga (1)
- JA/JA-Ile transport protein JAT1 (1)
- JCV (1)
- Jair Bolsonaro (1)
- Jean-Daniel Pollet (1)
- Jena Experiment (1)
- Joint capsule (1)
- Judaism (1)
- Julia line (1)
- J‐aggregates (1)
- K-region (1)
- KRAS (1)
- Kaff auch Mare Crisium (1)
- Kation (1)
- Kenyon cells (1)
- Keras (1)
- Kidney function (1)
- Kilombero (1)
- Korbblütler (1)
- Korrektur (1)
- Kreuzkupplungen (1)
- Kunduz River Basin (1)
- Künstliche Intelligenz (1)
- LC3 lipidation (1)
- LST (1)
- LSVT-big therapy (1)
- Landmarken (1)
- Langerhans cells (1)
- Langhaariges Habichtskraut (1)
- Laplace transform (1)
- Large vessel vasculitides (LVV) (1)
- Las Chicas del Cable (1)
- Lehrkräfte (1)
- Leopold II of Belgium (1)
- Lese-Rechtschreibstörung (1)
- Lewis acids (1)
- LiDAR (1)
- Ligamentum capitis femoris (1)
- Location-based algorithms (1)
- Los girasoles ciegos (1)
- Lower extremity reconstruction (1)
- MAPKAPK2 (1)
- MCC (1)
- MCPyV (1)
- MCV-negative (1)
- MEK/ERK-signaling (1)
- MEN1 (1)
- MIND estimator (1)
- MLLE domain (1)
- MODIS (1)
- MOR202 (1)
- MPI (1)
- MPS (1)
- MR neurography (1)
- MSC (1)
- MSCs (1)
- MYC (1)
- Macrophages (1)
- Magnetic resonance imaging(MRI) (1)
- Magnetkompass (1)
- Main-group chemistry (1)
- Markov chains (1)
- Mass critical care (1)
- Medical education (1)
- Medical student (1)
- Mehrsprachigkeit (1)
- Meisenheimer complex (1)
- Melanocortin 4 receptor (MC4R) (1)
- Melanocyte stimulating hormones MSH (1)
- Mental health therapies (1)
- Merkel cell density (1)
- Merkel cell polyomavirus (1)
- Merlin (1)
- Mesenchymal stem cell (1)
- Messerstichverletzung (1)
- Methanosarcina mazei (1)
- Microarray analysis (1)
- Military shooting (1)
- Mitochondria (1)
- Mixed-Methods (1)
- Mobile application engineering (1)
- Mobile augmented reality (1)
- Mobile augmented reality game (1)
- Moleküle (1)
- Morocco (1)
- Moscherosch, Johann Michael / Les Visiones de Don Francesco de Quevedo Villegas (1)
- Mott–Schottky analysis (1)
- Multidetector computed tomography (1)
- Multilingualism (1)
- Multivariate analysis (1)
- Myeloma (1)
- N-heterocyclic carbenes (1)
- NAFLD (1)
- NASH (1)
- NDVI thresholds (1)
- NETs (1)
- NFATc1 (1)
- NGS (1)
- NHC Complexes (1)
- NLRP3 (1)
- NOTCH (1)
- NRF2 (1)
- NS1608 (1)
- NT‐proBNP (1)
- NanoFEEP (1)
- Natural product hybrids (1)
- Neisseria meningitidis (1)
- Neprilysin inhibition (1)
- Nesplora Aquarium (1)
- Netarsudil (1)
- Neuauflage (1)
- Neurodegeneration (1)
- Neuronal ceroid lipofuscinosis (1)
- Nickel Complexes (1)
- Nile Delta (1)
- Non-rigid image registration (1)
- Non-simultaneous bilateral distal biceps tendon rupture (1)
- Nordtirol (1)
- N‐Heterocyclic Carbenes (1)
- OEG chains (1)
- OLEDs (1)
- Olefin Complexes (1)
- Open-source tool (1)
- Ordination methods (1)
- Osmia bicornis (1)
- Osteoarthritis (1)
- Ottoman Empire (1)
- P300 (1)
- PABC1 (1)
- PABP (1)
- PAM2 (1)
- PAM2w (1)
- PARK2 (1)
- PD-L1 (1)
- PD‐L1 (1)
- PEComa (1)
- PER (1)
- PET/CT (1)
- PI stacking (1)
- PLEKHG5 (1)
- PML (1)
- PMMA (1)
- POU6F2-AS2 (1)
- PTSD (1)
- Paenibacillus (1)
- Pain questionnaire (1)
- Pancreatic islet (1)
- Parent–Child Interaction Therapy (PCIT) (1)
- Parkinson's disease (1)
- Parkinsonism (1)
- Parkionson's disease (1)
- Partizipation von Frauen (1)
- Patient Blood Management (PBM) (1)
- Patient education (1)
- Patient-centered registry (1)
- Patientenschulung (1)
- Patient’s needs (1)
- Pedicled perforator flap (1)
- Phedimus middendorffianus, var. diffusus (1)
- Phedimus spurius subsp. oppositifolius (1)
- Phenolic acids (1)
- Philippe Sollers (1)
- Photoelektronenspektroskopie (1)
- Photoisomerisierung (1)
- Pilot studies (1)
- Pityriasis lichenoides (1)
- Plant growth promotion (1)
- Plant root endophyte (1)
- Plattform (1)
- Pointing error (1)
- Poly(A) binding protein (1)
- Polymerase chain reaction (1)
- Pompe disease (1)
- Pom‐PAD‐Dara (1)
- Pontryagin maximum principle (1)
- Porcine eye (1)
- Post-traumatic stress disorder (1)
- Postcolonial Studies (1)
- Primary School (1)
- Prodigy (1)
- Propeller flap (1)
- Prophylaxe (1)
- Proprioception (1)
- Psychometrics (1)
- Puzzle Room (1)
- Puzzle room (1)
- QM/MM (1)
- Qb-Test (1)
- QoE fundamentals (1)
- QoS-QoE mapping functions (1)
- Quercus petraea (1)
- R (1)
- RAB GTPases (1)
- RFID (1)
- RLQ analysis (1)
- RNA (1)
- RNA Enzymes (1)
- RNA aptamers (1)
- RNA labeling (1)
- RNA ligation (1)
- RNA sequencing (1)
- RNA structures (1)
- RNA-Aptamere (1)
- RNA-Seq analysis (1)
- RNA-dependent RNA polymerase (1)
- RTX-Toxins (1)
- Radiation biology (1)
- Radiochemotherapy (1)
- Radiofluorine (1)
- Radiotherapy treatment planning (1)
- Ramadan (1)
- Raman (1)
- Ramsar Convention on Wetlands (1)
- Ranunculus auricomus (1)
- Ranunculus sarntheinianus (1)
- Rechtschreibung (1)
- Rectal cancer (1)
- Red Sea (1)
- Respiratory induced tumor motion (1)
- Rettungskette (1)
- Reuter, Christian / Schelmuffsky (1)
- Rheumatoid arthritis (1)
- Rheumatoide Arthritis (1)
- Rhizopus arrhizus (1)
- Rho-kinase inhibitor (1)
- Riemann zeta-function (1)
- Robuvit\(^®\) (1)
- Rollenbilder von Frauen (1)
- Rubus (1)
- Rubus boreofrisicus (1)
- S2k guidelines (1)
- SAR safety (1)
- SARS-CoV-2 brain disorders (1)
- SERS (1)
- SGLTs (1)
- SLC2A3 (1)
- SNP (1)
- SOAT1 (1)
- SOX9 (1)
- SPECT (1)
- SR Ca leak (1)
- ST-elevation myocardial infarction (1)
- STARFM (1)
- STP (1)
- Salmonella (1)
- Sanger sequencing (1)
- Savanna–Forest mosaic (1)
- Schleswig-Holstein (1)
- Schmidt, Arno (1)
- Schussverletzung (1)
- Schwann cells (1)
- Schütteltrauma (1)
- Scleractinia (1)
- Seahorse XF (1)
- Sedum oppositifolium (1)
- Sengers syndrome (1)
- Sentine-1 (1)
- Sentinel–1 (1)
- Serendipita indica (1)
- Serious game (1)
- Sert-deficient mice (1)
- Service-level Quality Index (SQI) (1)
- Severe Acute Respiratory Syndrome Coronavirus 2 (1)
- Shotgun method (1)
- Simon Stone (1)
- Simon task (1)
- Skin (1)
- Snail1 stability (1)
- Snf1 (1)
- Sonogashira reaction (1)
- Sporosarcina (1)
- Stokes-Verschiebung (1)
- Struktursonden (1)
- Strukturwandel (1)
- Stundengebet (1)
- Stylissa carteri (1)
- Sunitinib (1)
- Supersymmetry (1)
- Suprascapular nerve (1)
- Suture anchor (1)
- Synthetic biology (1)
- Systematics (1)
- Systemic sclerosis (1)
- T cell (1)
- T cell receptor (1)
- T cells (1)
- T lymphocytes (1)
- T-follicular regulatory cell (1)
- TIMP-1 (1)
- TLR agonists (1)
- TMD (1)
- TNAP (1)
- TNFSF14 (1)
- TNFSF4 (1)
- TOR1A (1)
- TRIM32 (1)
- TRPA1 (1)
- TSLP (1)
- TTK (1)
- Tdp-43 (1)
- Teachers (1)
- Teichholz formula (1)
- Temperatur (1)
- Terroranschlagtrauma (1)
- Textqualität (1)
- Thalassodendron ciliatum (1)
- Tilia cordata (1)
- Time interval (1)
- Tissue engineering (1)
- Titanium (1)
- Toll-like receptor 4 (TLR4) (1)
- Tomography (1)
- Tradition (1)
- Training (1)
- Transcriptomics (1)
- Trauma (1)
- TreMs (1)
- Tregs (1)
- Triangular fibrocartilage (1)
- Triboran (1)
- Trilobita (1)
- TrkB (1)
- Trypanosoma cruzi (1)
- Tyrosine kinase inhibition (1)
- UBE3A (1)
- UPPS (1)
- UWE-4 (1)
- Universitätsbibliothek Würzburg (1)
- Unterricht (1)
- Uruk (1)
- VCE (1)
- VSOP (1)
- Varroa destructor (1)
- Vasculitis (1)
- Vegetable juice (1)
- Verhalten und Verhaltensmechanismen (1)
- Videoanalyse (1)
- Virtual sequencing (1)
- Visualisierung (1)
- Visualization (1)
- Vitamin-K-Mangel-Blutung (1)
- Wallonia (1)
- West Gondwana (1)
- Wiederbelebung (1)
- Winston‐Lutz test (1)
- Wissenschaftliche Bibliothek (1)
- Wnt/β-catenin signaling (1)
- Woolf, Viriginia (1)
- Wright functions (1)
- Wrist (1)
- Würzburg (1)
- Würzburg University Library (1)
- X-ray computed (1)
- X-ray diffraction (1)
- X‐ray crystallography (1)
- Y-box binding protein 1 (1)
- YTHDF1 (1)
- Zellen (1)
- \(\pi\) interactions (1)
- \(\pi\)-Komplexe (1)
- \(^{18}\)F (1)
- \(^{68}\)Ga (1)
- ab interno trabeculectomy (1)
- abdominal trauma (1)
- absorption (1)
- acceptance (1)
- acceptance-based strategy (1)
- access caity preparation (1)
- accuracy (1)
- acenes (1)
- acetabular bone defect (1)
- acetylcholine (1)
- acid-sensitive (1)
- acids (1)
- acipenserid minisatellite (1)
- actin cytoskeleton (1)
- action (1)
- action binding (1)
- action planning (1)
- action–effect compatibility (1)
- activity rhythm (1)
- activity-based probes (1)
- acupuncture (1)
- acute decompensated heart failure (1)
- acute ischemic stroke (1)
- acute kidney injury (1)
- acute lymphoblastic leukaemia (1)
- acute pain (1)
- acute respiratory distress syndrome (1)
- acylcarnitine (1)
- adalimumab (1)
- adaptation phase (1)
- adaptive conflict (1)
- adenosine diphosphate (1)
- adenosine receptors (1)
- adenylate cyclase toxin (1)
- adhesion (1)
- adipose tissue-derived MSCs (1)
- adipose-derived stromal/stem cells (ASCs) (1)
- adolescent (1)
- adolescents (1)
- adult bees (1)
- adult neurogenesis (1)
- adults (1)
- adverse events (1)
- aelf-assembly (1)
- aerospace engineering (1)
- affect-regulating massage therapy (1)
- affective disorders (1)
- affective touch (1)
- agarose (1)
- aged 80 and over (1)
- ageing (1)
- agency (1)
- aggressive B‐cell lymphoma (1)
- agranulocytosis (1)
- agreement (1)
- agricultural mapping (1)
- aldosterone (1)
- alginate (1)
- algorithm (1)
- alignmen (1)
- alkaline phosphatase (1)
- alkaloid detection methods (1)
- alkaloids (1)
- allene oxide synthase (1)
- allergic airway inflammation (1)
- allergies (1)
- allergy (1)
- allocation (1)
- alpaca (1)
- alpha oscillations (1)
- alpha1 (1)
- altitudinal gradient (1)
- altruistic compensation (1)
- aluminium (1)
- aluminum (1)
- ambrosia beetles (1)
- amino acids (1)
- amoxicillin (1)
- amphiphilic dyes (1)
- amphiphilic systems (1)
- ampicillin (1)
- amplicon sequencing (1)
- anaemia walk‐in clinic (1)
- analytics (1)
- anatomic center of rotation (1)
- androgen deprivation therapy (1)
- anesthetics (1)
- angioedema (1)
- angiotensin (1)
- animal models of human disease (1)
- animal tracking (1)
- animation (1)
- annotation (1)
- anomaly detection (1)
- anomaly prediction (1)
- anorectal angl (1)
- ant brain (1)
- antagomiRs (1)
- antagonists (1)
- antenna (1)
- antennal lobes (1)
- anterior approach (1)
- anthropogenic food subsidies (1)
- anthropometric measurements (1)
- anti-cancer drug-like molecules (1)
- anti-drug antibodies (1)
- anti-science (1)
- antibody/autoantibody (1)
- anticoagulation (1)
- antidepressant (1)
- antigen presentation (1)
- antithrombotic therapy (1)
- ants (1)
- apolipoprotein-E (1)
- aposematism (1)
- app (1)
- architectural design (1)
- architecture (1)
- areas (1)
- arithmetic calculations (1)
- arrhythmia (1)
- arrhythmogenic cardiomyopathy (1)
- artesunate (1)
- arthritis (1)
- articular chondrocytes (1)
- artificial neural network (1)
- asfotase alfa (1)
- aspirin‐exacerbated respiratory disease (1)
- assay (1)
- assembly mechanisms (1)
- assistive devices (1)
- asthma (1)
- asthma risk (1)
- asymmetric implant (1)
- atheriosclerosis (1)
- atherosclerosis (1)
- athletes (1)
- atmosphere (1)
- atmospheric correction (1)
- atomic-force microscopy (1)
- atrial fibrillation (1)
- attention deficit/hyperactivity disorder (1)
- attentional boost effect (1)
- attitude to death (1)
- atypical tetracyclines (1)
- at‐risk (1)
- auditory cortex (1)
- augmented Lagrange method (1)
- autobiography (1)
- autoimmune (1)
- autoimmune encephalitis (1)
- autoimmune thyroiditis (1)
- autologous stem cell transplantation (1)
- autonomous (1)
- autophagosome formation (1)
- autosomal recessive hearing loss (1)
- autotoxicity (1)
- axonal transcriptome (1)
- azadiboretidines (1)
- azlactone (1)
- azole resistance (1)
- back pain (1)
- bacterial infection (1)
- bacterial infections (1)
- bacterial resistance (1)
- bacterial spread (1)
- bacterial transmission (1)
- baited traps (1)
- bariatric surgery (1)
- bark beetle (1)
- bark beetles (1)
- bark-peeling (1)
- basal ganglia (1)
- base excision repair (incision activity) (1)
- base of support (1)
- base pairs (1)
- basic (1)
- beam computed tomography (1)
- bee conservation (1)
- beech forest (1)
- beetle (1)
- behavior and behaviormechanisms (1)
- behavioral disorders (1)
- behavioral plasticity (1)
- behavioural plasticity (1)
- benzylguanidine (1)
- bet-hedging (1)
- beta-D-glucan (1)
- beta-diversity (1)
- biased signaling (1)
- binding affinity (1)
- binding protein (1)
- binding sites (1)
- bioactive compounds (1)
- bioactivity (1)
- biodiversity threats (1)
- bioinformatics (1)
- bioink (1)
- bioinspired interface (1)
- biological barriers (1)
- biological macromolecules (1)
- biological models (1)
- biology (1)
- biomarker variability (1)
- biomass (1)
- biomaterials (1)
- biomechanic (1)
- biomechanical engineering (1)
- biomimetics (1)
- biophysical investigation (1)
- biophysics (1)
- biopsies (1)
- biosecurity (1)
- bird communities (1)
- birds (1)
- birth cohort study (1)
- bisphosphonates (1)
- blazars (1)
- bleding disorders other than hemophilia (1)
- blinatumomab (1)
- blinks (1)
- blisters (1)
- blood brain barrier (1)
- blood coagulation factor XIII (1)
- blood flow (1)
- blood loss (1)
- blood sedimentation (1)
- blood stream (1)
- blood transfusion (1)
- blood vessel (1)
- blood-brain barrier (1)
- blood‐brain barrier (BBB) (1)
- blood–brain barrier (1)
- body (1)
- body ownership (1)
- body psychotherapy (1)
- bolus-based perfusion measurement (1)
- bombus terrestris (1)
- bond Activation (1)
- bond formation (1)
- bonding (1)
- bonding analysis (1)
- bone QCT (1)
- bone and cartilage tissue engineering (1)
- bone autoinflammation (1)
- bone fractures (1)
- bone marrow angiogenesis (1)
- bone marrow biopsy (1)
- bone marrow–spleen–liver large B‐cell lymphoma (1)
- bone mineral density (1)
- bone regeneration (1)
- bone tumour (1)
- bone-marrow (1)
- borafluorenes (1)
- boranes (1)
- boron tetraiodide (1)
- bottom‐up and top‐down control (1)
- brain bank (1)
- brain development (1)
- brain metabolic alterations (1)
- brain-computer interface (BCI) (1)
- breakthrough (1)
- breastfeeding (1)
- breeding (1)
- breeding season (1)
- bridging (1)
- broad-spectrum antibiotics (1)
- broadleaf tree species (1)
- bronchopulmonary dysplasia (1)
- bronchopulmonary dysplasia (BPD) (1)
- brush cells (1)
- bryophytes (1)
- building behavior (1)
- buildup region (1)
- bulk-heterojunction solar cells (1)
- butyrophilin (1)
- butyrophilin 2A1 (1)
- butyrophilin 3 (1)
- bypass (1)
- cAMP (1)
- cGMP (1)
- calcaneus (1)
- calcium signaling pathway (1)
- calmodulin (1)
- camera perspective (1)
- canal calcification (1)
- cancer metabolism (1)
- cancer therapy (1)
- cancer vaccines (1)
- cancer-testis antigens (1)
- candidate genes (1)
- candidemia (1)
- canine adipose-derived mesenchymal stem cells (cAdMSCs) (1)
- canine cancer cell lines (1)
- canine cancer therapy (1)
- canine soft tissue sarcoma (CSTS) (1)
- capsaicin (1)
- capture (1)
- carbene ligands (1)
- carbocations (1)
- carbohydrates (1)
- cardiac magnetic resonance imaging (1)
- cardiac surgery (1)
- cardiogenetics (1)
- cardiolipin (1)
- cardiorespiratory centre (1)
- cardiovascular MR methods (1)
- care tempis (1)
- carfilzomib (1)
- carrion ecology (1)
- cascade (1)
- caspases (1)
- casposon (1)
- cathepsin (1)
- cationic species (1)
- cbt (1)
- ceiba pentandra (1)
- cell cycle (1)
- cell elongation (1)
- cell fate (1)
- cell guidance (1)
- cell printing (1)
- cell transplantation (1)
- cell‐based therapy (1)
- cement (1)
- central complex (1)
- ceramics (1)
- ceramide (1)
- cereals (1)
- cerebEND cells (1)
- cerebellar tDCS (1)
- cerebellar vermis hypoplasia (1)
- cerebellum (1)
- cerebroside (1)
- cerebrosides (1)
- cerebrospinal fluid (1)
- cfRNA (1)
- chain-of-survival (1)
- chalcogens (1)
- chalcone (1)
- channel transport (1)
- chaperone (1)
- characterization (1)
- checkered beetles (1)
- checkpoint inhibitors (1)
- chelocardins (1)
- chemerin (1)
- chemical mimicry (1)
- chemokine receptor (1)
- chemotherapy (1)
- chemotherapy (CH) (1)
- child (1)
- child health (1)
- childhood and adolescence (1)
- chimeric antigen receptor (1)
- chimpanzee (1)
- chiral resolution (1)
- chondrogenic differentiation (1)
- chondroprogenitors (1)
- chromatin regulator (1)
- chromosome 21 (1)
- chronic disorders (1)
- chronic heart failure (1)
- chronic kidney disease (1)
- chronic non-bacterial osteomyelitis (1)
- chronic pulmonary insufficiency of prematurity (1)
- chronic recurrent multifocal osteomyelitis (1)
- chronic urticaria (1)
- chronophin (1)
- circadian rhythms (1)
- circular dichrosism (1)
- circulating microRNA (1)
- classification (1)
- click chemistry (1)
- climate parameters (1)
- clinical diagnosis (1)
- clinical isolates (1)
- clinical studies (1)
- clinical study (1)
- clinical trial (1)
- closeness (1)
- cloud-native (1)
- co-culture (1)
- co-worker similarity (1)
- coagulation (1)
- coating (1)
- cochlea (1)
- cognitive and attentional control (1)
- cognitive dysfunction (1)
- cognitive impairment (1)
- cognitive strategies (1)
- cohort study (1)
- cold storage (1)
- collective building (1)
- collective pattern (1)
- colonoscopy (1)
- color centers (1)
- combination of physical vapor deposition and electrochemical etching (1)
- combined targeted therapy (1)
- combined therapy (1)
- common garden experiment (1)
- common variable immunodeficiency (1)
- community composition (1)
- community data (1)
- community‐weighted mean (1)
- comparability (1)
- comparative empirical research (1)
- compensatory strategies (1)
- complementary medicine (1)
- complex behavior (1)
- complexes (1)
- complexity (1)
- complications (1)
- comportement des travailleurs (1)
- composite supraparticles (1)
- compressible fluid (1)
- compression syndrome (1)
- computational fluid dynamics (1)
- concealed identity information (1)
- conditional mutants (1)
- conflict resolution (1)
- conformational auto-epitope (1)
- congenital myopathy (1)
- congestion (1)
- conjugation (1)
- connectance (1)
- connective tissue (1)
- connectome (1)
- consanguinity (1)
- consciousness (1)
- conservation (1)
- consolidation (1)
- consumptive water use (1)
- containment (1)
- continuous performance test (1)
- continuous positive airway pressure (CPAP) (1)
- continuous wavelet analysis (1)
- continuous-time SLAM (1)
- contrast agent (1)
- contrast media (1)
- cool-season grass species (1)
- cooperative breeding (1)
- coping skills (1)
- copy number variation (1)
- copy number variations (1)
- cornea (1)
- corneal confocal microscopy (1)
- corpus linguistics (1)
- cortical neurons (1)
- corticosteroids (1)
- cost-share theorem (1)
- costly punishment (1)
- coumarin (1)
- coupling reactions (1)
- coupling-constant dependence (1)
- course (1)
- covalent inhibitors (1)
- covalent reversible inhibition (1)
- craniosynostosis (1)
- creatine kinase (1)
- credibility (1)
- cristae (1)
- critical care (1)
- critical illness (1)
- critical line (1)
- crop growth models (1)
- cross-coupling (1)
- cross-link repair (1)
- crosslinked coating (1)
- cross‐coupling (1)
- crowded housing (1)
- crystals (1)
- cultural memory (1)
- culturally and linguistically diverse patients (1)
- curcumin (1)
- current source density (1)
- curved π-systems (1)
- cutaneous PEComa (1)
- cutaneous innervation (1)
- cuticular hydrocarbons (1)
- cyanoborates (1)
- cyber-physical systems (1)
- cybersickness (1)
- cycle (1)
- cyclic nucleotides (1)
- cyclic peptides/cyclopeptides (1)
- cyclopenten-4-yl cation (1)
- cyclopeptide therapy (1)
- cysteine protease (1)
- cytokines (1)
- cytokinins (1)
- cytome biomarkers (1)
- cytotoxic T cells (1)
- cytotoxicity (1)
- damage control surgery (1)
- dapsone (1)
- daratumumab (1)
- data collection (1)
- data fusion (1)
- data stream processing (1)
- ddPCR (1)
- deadwood (1)
- deadwood experiments (1)
- decision support techniques (1)
- decision-making (1)
- defects (1)
- defense signaling (1)
- defined humanized test system (1)
- definition (1)
- definitions of psychology (1)
- deformation-based method (1)
- dehydrocoupling (1)
- dementia (1)
- demographics (1)
- demography (1)
- dendritic cells (1)
- dendritic specializations (1)
- density functional calculations (1)
- density functional theory (1)
- density-functional calculations (1)
- dental roots (1)
- dentin dysplasia (1)
- dentin post (1)
- deployment (1)
- dermatology (1)
- design (1)
- desmosomes (1)
- detection rate (1)
- developmental biology (1)
- developmental dyslexia (1)
- dewatering (1)
- di-\(\pi\)-methane rearrangement (1)
- diabetic polyneuropathy (1)
- diachronicity (1)
- diagnostic medical radiation exposure (1)
- diapause (1)
- diazadiborinines (1)
- dibenzosemibullvalenes (1)
- diborane (1)
- diboranes (1)
- diboration (1)
- diborynes (1)
- dictation (1)
- dictator game (1)
- differential scanning calorimetry (1)
- differentiated thyroid carcinoma (1)
- differentiation (1)
- differentiation capacity (1)
- differentiation potential (1)
- diffuse large B‐cell lymphoma (1)
- diffusion-wave equation (1)
- digital health (1)
- digital technologies (1)
- digital transformation (1)
- dimerization (1)
- diode (1)
- direct drivers (1)
- discharge definition (1)
- discotic liquid crystals (1)
- discursive strategy (1)
- disease (1)
- disease modelling (1)
- disease models (1)
- dispersal ability (1)
- distal deletion (1)
- distance gradient (1)
- distraction (1)
- divergence times (1)
- docking studies (1)
- domain (1)
- domain swapping (1)
- donor-acceptor interactions (1)
- donor-cell leukemia (1)
- dorsal root ganglion (1)
- drosophila (1)
- drug depots (1)
- drug design (1)
- drug permeability screening (1)
- drug screening (1)
- drug transport (1)
- drug transporter (1)
- drug-loaded hydrogels (1)
- drugs (1)
- dual function (1)
- dual task procedures (PRP) Introduction In everyday (1)
- dual-energy CT (1)
- dual-room whole-body CT (1)
- dual-task performance (1)
- duplicate genes (1)
- dye adsorption (1)
- dyes (1)
- dynamic perceptual simulation; (1)
- dystonia (1)
- eCPR (1)
- eCognition (1)
- early detection (1)
- early intervention (1)
- early prognosis (1)
- early recognition (1)
- ecological connectivity (1)
- ecological intensification (1)
- ecological momentary assessment (1)
- ecological momentary assessments (1)
- ecological momentary assessments (EMA) (1)
- ecological network (1)
- ecological niche (1)
- ecosystem services (1)
- ectoine biosynthesis (1)
- ectopic lymphoid follicle (1)
- edge states (1)
- effect anticipations (1)
- effectiveness (1)
- effects (1)
- efflux pumps (1)
- electric propulsion (1)
- electrical impedance tomography (1)
- electrocatalysis (1)
- electrochemical conversion (1)
- electrochemical fluorination (1)
- electrodermal activity (1)
- electrohydrodynamics (1)
- electrolytes (1)
- electromyographic/electrocardiographic data (1)
- electron (1)
- electron microscopy (1)
- electron storage (1)
- electron tomography (1)
- electrophilic (het)arene (1)
- element (1)
- elementary school (1)
- elevational diversity (1)
- elevational gradients (1)
- embodied cognition (1)
- emissions (1)
- emissivity (1)
- emotion display (1)
- emotion regulation (1)
- emotional regulation (1)
- empirical investigation (1)
- end-user programming (1)
- endocytosis (1)
- endothelial cell (1)
- endothelial cells (1)
- endurance training (1)
- energy intake (1)
- energy metabolism (1)
- ensemble reachability (1)
- enterococci (1)
- entresto (1)
- entropy (1)
- environmental filtering (1)
- epidemiology (1)
- epidermis (1)
- epigenetic reader (1)
- epithelial cells (1)
- epitranscriptome (1)
- ergosterol derivative (1)
- error detection (1)
- essay film (1)
- essential genes (1)
- establishment (1)
- estrogens (1)
- ethenoanthracenes (1)
- etoposide (1)
- eugenol (1)
- event-related-potential (ERP) (1)
- evolutionary (1)
- exact matching (1)
- exanthem (1)
- excimer laser ablation (1)
- exercise intensity (1)
- exit (1)
- exotic plants (1)
- experimental design (1)
- experimental evaluation (1)
- extracellular vesicle (1)
- extracorporeal membrane oxygenation (1)
- extraction (1)
- extramedullary disease (1)
- factor VIII (1)
- factor XI (1)
- factor XII (1)
- factor-VIII (1)
- facultatively intracellular pathogens (1)
- failure prediction (1)
- family (1)
- fascia (1)
- fat mass (1)
- fatigue (1)
- fatty acids (1)
- fear (1)
- feedback (1)
- feeding (1)
- feeding experiment (1)
- feeding guilds (1)
- female authorship (1)
- female participation (1)
- female roles (1)
- feminist peace research (1)
- ferroptosis (1)
- filamin C (1)
- fine root biomass (1)
- fine root necromass (1)
- fire (1)
- first responders (1)
- fixed drug eruption (1)
- flagellar pocket (1)
- flavonoids (1)
- flight behaviour (1)
- flippase (1)
- floodpath lake (1)
- floral display (1)
- floral resources (1)
- flow patterns (1)
- flower-visiting insects (1)
- fluconazole resistance (1)
- fluid–structure interaction model (1)
- fluorescence microscopy (1)
- fluorescence resonance energy transfer (1)
- fluorescent ligands (1)
- fluorination (1)
- fluoroarenes (1)
- fluoroborates (1)
- flupyradifurone (1)
- focal adhesion (1)
- focalization (1)
- folliculin (1)
- food allergy (1)
- food production (1)
- force (1)
- forecast (1)
- forensic anthropology (1)
- forensic neuropathology (1)
- forensic neurotraumatology (1)
- forensic osteology (1)
- forest conservation (1)
- forest degradation (1)
- forest disturbances (1)
- forest monitoring (1)
- forest pests (1)
- forest physiognomy (1)
- forest succession (1)
- forms (1)
- fourth (1)
- fractional calculus (1)
- fracture (1)
- frailty (1)
- frameshift (1)
- free energy (1)
- free‐breathing (1)
- fructose intolerance (1)
- fullerenes (1)
- functional network analysis (1)
- functional thinking (1)
- functional traits (1)
- fungal aerosolization (1)
- fungal antigens (1)
- fungal infection (1)
- fungal infections (1)
- fungi (1)
- fungus community (1)
- fungus-farming (1)
- fused in sarcoma (1)
- galamsey (1)
- gamma H2AX-foci (1)
- gastrointestinal infection (1)
- gender (1)
- gender development (1)
- gene (1)
- gene duplications (1)
- gene therapy (1)
- general anaesthesia (1)
- general anesthesia (1)
- generalization (1)
- generalized cerebellar atrophy (1)
- generation (1)
- genetic diagnosis (1)
- genetic phenotypes (1)
- genetic polymorphisms (1)
- genetic susceptibility (1)
- genetics (1)
- genome-wide linkage analysis (1)
- genomes of photosynthetic bacteria (1)
- genomic selection (1)
- genomics (1)
- geoanalysis (1)
- geospatial data (1)
- giant cell arteritis (1)
- gingivitis (1)
- glacier–permafrost interaction (1)
- glaucoma surgery (1)
- global attractor (1)
- global care (1)
- global change (1)
- glucose starvation (1)
- glucose tolerance (1)
- glucose transport (1)
- glucose-galactose malabsorption (1)
- glucosetransporter (1)
- glycine betaine biosynthesis (1)
- glycine receptor (1)
- glycine receptor autoantibodies (1)
- glycogenin 1 (1)
- glycopeptide antibiotics (1)
- gold nanoparticles (1)
- gonococcal invasion (1)
- gradient impulse response function (1)
- gradient system respose (1)
- gradient system trasfer function (1)
- gradients (1)
- graft (1)
- grain boundaries (1)
- granular (1)
- graph adaptivity (1)
- graph ergonomics (1)
- grass endophytes (1)
- grasslands (1)
- grazing (1)
- ground‐dwelling predators (1)
- group treatment (1)
- growth (1)
- growth differentiation factor 15 (1)
- guard cells (1)
- guided endodontics (1)
- guidelines (1)
- hBMSC (1)
- hMSCs (1)
- habitat filter (1)
- habitat heterogeneity (1)
- habits (1)
- haemodynamic monitoring (1)
- haemoglobin concentration (1)
- haemostasis (1)
- halides (1)
- haloacid dehalogenase (1)
- halogenation (1)
- harvesting (1)
- healing and remodelling processes (1)
- health behavior (1)
- healthcare (1)
- health‐related quality of life (1)
- hearing (1)
- hearing loss (1)
- heart rate variability (1)
- heart structure (1)
- heat shock response (1)
- helicase (1)
- helminthes (1)
- hematologic malignancies (1)
- hematological malignancies (1)
- hematology (1)
- hemodialysis (1)
- hemoglobin (1)
- hemostasis and thrombosis (1)
- hepatic fibrosis (1)
- heterocyclic carbenes (1)
- heterogeneous catalysis (1)
- heterosis (1)
- high contrast (1)
- high-field MRI (1)
- high-risk Prostate Cancer (1)
- high-temperature chemistry (1)
- high‐grade B‐cell lymphoma (1)
- hip joint (1)
- hippocampus (1)
- histamine (1)
- histology (1)
- histone (1)
- histone methyltransferase PRDM8 (1)
- historical (1)
- homodimerization (1)
- homogenous parameter-depedent systems (1)
- honey bee (1)
- honey bees (1)
- honeybee (1)
- horses (1)
- hospital chaplaincy (1)
- hospital-based palliative care (1)
- hospitals (1)
- host (1)
- host-guest systems (1)
- human adipose-derived stromal cells (1)
- human breast (1)
- human exposure (1)
- human macrophages (1)
- human neurons (1)
- human rights (1)
- human‐induced pluripotent stem cells (hiPSC) (1)
- hydroboration (1)
- hydrogel (1)
- hydrogen (1)
- hydrology (1)
- hyperconjugation (1)
- hyperparathyroidism (1)
- hyphae (1)
- hypodontia (1)
- hypogammaglobulinemia (1)
- hypothyroidism (1)
- hypovitaminosis D (1)
- hypthesis (1)
- hysterectomy (1)
- iPSC (1)
- iStent (1)
- ice sheet dynamics (1)
- ideomotor theory (1)
- idiopathic fecal incontinence (1)
- image artifacts (1)
- image denoising (1)
- images (1)
- imaging (1)
- imaging agents (1)
- imide ligands (1)
- imidization (1)
- immune checkpoint blockade (1)
- immune therapy (1)
- immune-checkpoint inhibitor (1)
- immunity (1)
- immuno-oncology (1)
- immunofuorescence double staining (1)
- immunoglobulins (1)
- immunology (1)
- immunotherapeutics (1)
- impact (1)
- impact of humidity and temperature (1)
- implant (1)
- implant positioning (1)
- implementation (1)
- in silico simulation (1)
- in situ hybridization (1)
- in-orbit experiments (1)
- inattention/hyperactivity (1)
- incidence (1)
- incidental encoding (1)
- indicator importance assessment (1)
- individual based model (1)
- induced neural stem cells (1)
- inducible expression (1)
- infarction volume (1)
- infected-cell protein (1)
- infection (1)
- infection rates (1)
- infectious disease (1)
- inferior vena cava (1)
- inflammasome (1)
- inflammation-induced tissue demage (1)
- inflammatory cytokines (1)
- inflammatory demyelinating polyradiculoneuropathy (1)
- inflammatory response (1)
- influenza (1)
- inhibitory signaling (1)
- inpatient rehabilitation (1)
- insect (1)
- insect agriculture (1)
- insect fungal interactions (1)
- insect nutrition (1)
- insect vision (1)
- insecticide (1)
- insects (1)
- integrase (1)
- integrin (1)
- intelligence (1)
- intelligent transportation systems (1)
- intensity distribution (1)
- intensity zones (1)
- intensive care medicine (1)
- intentional encoding (1)
- interaction (1)
- interaction map (1)
- interactome (1)
- interacts (1)
- interleukin 1 (1)
- interleukin 18 (1)
- internal load (1)
- internet-based intervention (1)
- interoception (1)
- interparticle interaction (1)
- interpreter (1)
- interspecies comparison (1)
- intersystem crossing (1)
- intracranial bleeding (1)
- intraepidermal nerve fibre density (1)
- intravascular large B‐cell lymphoma (1)
- intrinsic free space (1)
- invasive species (1)
- iodine-131 (1)
- ion pairing (1)
- ionic liquids (1)
- iron oxide nanoparticles (1)
- ischemia (1)
- isocenter (1)
- isomorphic nucleobase analog (1)
- isosteviol sodium (1)
- isothiocyanates (1)
- jasmonoyl-isoleucine (1)
- jewel beetles (1)
- jitter (1)
- ketamine anaesthesia (1)
- kidney (1)
- kidney ischemia/reperfusion injury (1)
- kinease (1)
- kink instability (1)
- knee axis (1)
- knee osteoarthritis (1)
- knock down (1)
- laboratory animals (1)
- lactate dehydrogenase (1)
- laminar recording (1)
- land cover change (1)
- land surface (1)
- land surface dynamics (1)
- land-use change (1)
- land-use intensity (1)
- land-use/land-cover change (1)
- landcover changes (1)
- landmarks (1)
- landscape structure (1)
- language barriers (1)
- lantana canescens (1)
- laparoscopic surgery (1)
- large stokes shift (1)
- latency (1)
- lattices (1)
- lean mass (1)
- lectotype (1)
- left ventricular hypertrophy (1)
- left ventricular mass index (1)
- lenalidomide (1)
- lentic inland water bodies (1)
- lentiviral transduction (1)
- lesions (1)
- lessons learned (1)
- lexical co-occurrences (1)
- life (1)
- life-threatening side-effects (1)
- ligands (1)
- lipid asymmetry (1)
- lipid bilayer (1)
- lipid metabolism (1)
- liquid biopsy (1)
- liquid chromatography electrospray ionization tandem mass spectrometry (1)
- literature search (1)
- live imaging (1)
- liver (1)
- livestock (1)
- local existence (1)
- local input-to-state stability (1)
- locomotor adaptation (1)
- long-term complications (1)
- long-term exposure (1)
- long‐term monitoring (1)
- lonlinear reaction-diffusion equations (1)
- loss (1)
- low fidelity (1)
- low molecular heparin (1)
- low-cost applications (1)
- lowland rainforest (1)
- lung (1)
- lung fibrosis (1)
- lymphocytes (1)
- lymphoid aggregate (1)
- lymphoplasmacellular osteomyelitis (1)
- lysosome (1)
- lyso‐Gb3 (1)
- m-Health (1)
- mRNA (1)
- mRNA expression (1)
- m\(^6\)A (1)
- maceration (1)
- macrophage polarization (1)
- magnetic particles (1)
- magnetic properties (1)
- magnetic resonance neurography (1)
- magnetic resoncance (1)
- main-group metals (1)
- maintenance of genomic integrity (1)
- malignancy (1)
- mantle cell lymphoma (1)
- mapping (1)
- marine bacteria (1)
- marine fungi (1)
- marine metagenomics (1)
- marine organisms (1)
- massage therapy (1)
- material composition (1)
- maternal asthma (1)
- mathematics (1)
- matrix metalloproteinases (1)
- measurements (1)
- measures (1)
- mechanical engineering (1)
- mechanical ventilation (1)
- mechanics (1)
- mechanism (1)
- mechanism of resistance (1)
- mechanosensing (1)
- media (1)
- medical history taking (1)
- melanoma malignancy (1)
- melt electrospinning writing (1)
- melt electrowriting (MEW) (1)
- membrane (1)
- membrane interaction (1)
- membrane occupation (1)
- memory (1)
- memory B cells (1)
- meningeal inflammation (1)
- mental disorders (1)
- mental effort (1)
- mentalizing (1)
- mesogens (1)
- mesoscopic (1)
- messenger RNA (1)
- meta-transcriptome (1)
- metabarcoding (1)
- metabolic adaptation (1)
- metabolic analysis (1)
- metabolic reprogramming (1)
- metabolic tumor volume (MTV) (1)
- metabolic tumour volume (MTV) (1)
- metabolism (1)
- metabolomics (1)
- meta‐analysis (1)
- methanoarchaea (1)
- methionine (1)
- method comparison (1)
- methods in psychology (1)
- methylbismuth (1)
- methyltransferase (1)
- miR (1)
- miR-375 (1)
- miR-483-5p (1)
- mice (1)
- microRNA (1)
- microRNA-221 (1)
- microbe carrier (1)
- microcircuitry (1)
- microenvironment (1)
- microfibres (1)
- microglia (1)
- microglomeruli (1)
- microionization chambers (1)
- micronuclei (1)
- microparticles (1)
- microplastics (1)
- microscopy (1)
- microstructure (1)
- midfrontal theta activation (1)
- migration and invasiveness (1)
- mimicry rings (1)
- mindfulness (1)
- mineral bone density (1)
- mineralization (1)
- mineraliztion (1)
- minimally invasive surgery (1)
- mining (1)
- mismatches (1)
- mission strategies (1)
- mitochondrial activity (1)
- mitochondrial dynamics (1)
- mitochondrial pathology (1)
- mitochondrial translation (1)
- mitotane (1)
- mobile EEG (1)
- mobile apps (1)
- mobile crowdsensing (MCS) (1)
- mobile health (1)
- mobile healthcare application (1)
- mobile operating system differences (1)
- mobile phone (1)
- model (1)
- modeling (1)
- modularity (1)
- molecular cloning (1)
- molecular diagnosis (1)
- molecular doping (1)
- molecular modelling (1)
- molecular structure (1)
- molecular subtypes (1)
- monocytes (1)
- mononuclear (1)
- moral balancing (1)
- morbidity (1)
- mortality rate (1)
- motor control (1)
- motor entrainment (1)
- motor neuron disease (1)
- mountain permafrost (1)
- movement (1)
- movement data (1)
- movement disorders (1)
- movement tracking (1)
- mowing (1)
- mucociliary clearance (1)
- multidrug-resistant bacteria (1)
- multifocal growth (1)
- multiple bonds (1)
- multiplex PCR (1)
- multirotors (1)
- multiscale methods (1)
- multisensory processing (1)
- multispectral VNIR (1)
- multitemporal metrics (1)
- murine (1)
- muscarinic M1 receptor (1)
- muscle (1)
- muscle atrophy (1)
- muscle disease (1)
- muscular dystrophy (1)
- mushroom bodies (1)
- mushroom body (1)
- music (1)
- musk myasthenia gravis (1)
- mustard oil bomb (1)
- mutation (1)
- mutualistic interactions (1)
- mycotoxin (1)
- mycotoxins (1)
- myocardial blood flow (1)
- myocardial infarction (1)
- myocardial perfusion reserve (1)
- myokines (1)
- myotonia congenita (1)
- nOAC (1)
- nanoplastics (1)
- nanoscale imaging (1)
- nanosegregation (1)
- nanotopographical surfaces (1)
- natural disturbances (1)
- natural killer cell (1)
- natural transformation (1)
- naturally occurring polymorphisms (1)
- nature (1)
- nature conservation (1)
- near surface geophysics (1)
- necrobiome (1)
- necromass/biomass ratio (1)
- negative density dependence (1)
- neonate (1)
- neotropical region (1)
- neotype (1)
- nephrocyte (1)
- nerve (1)
- nerve-fibers (1)
- nervous system (1)
- network (1)
- network specialization index (H2′) (1)
- networking (1)
- neural (1)
- neural architecture (1)
- neural stem cell (1)
- neural stem cells (1)
- neuroborreliosis (1)
- neurocognitive outcome (1)
- neurodegeneration (1)
- neurodegenerative diseases (1)
- neurodevelopment (1)
- neuroendocrine tumor (1)
- neurofascin (1)
- neurogenesis (1)
- neuroinvasion (1)
- neurological symptoms/disorders (1)
- neuromuscular junction (1)
- neuronal differentiation (1)
- neuronal network (1)
- neuronal stem cells (1)
- neuropathic pain (1)
- neuropathy (1)
- neuropsychiatry (1)
- neuropsychology (1)
- neurotoxicity (1)
- neurotransmission (1)
- neutral processes (1)
- neutral sphingomyelinase-2 (1)
- neutrophils (1)
- new Rubus species (1)
- newly diagnosed (1)
- next generation sequencing (NGS) (1)
- nicotinamide (1)
- nicotinamide nucleotide transhydrogenase (1)
- nilotinib (1)
- nitrogen ligands (1)
- nodal knots (1)
- nomadic identities (1)
- non-communicable disease (1)
- non-equilibrium thermodynamics (1)
- non-invasive respiratory support (1)
- non-invasive ventilation (1)
- non-oncological (1)
- non-personalised tips (1)
- non-sense mediated mRNA decay (1)
- non-smooth large-scale optimisation (1)
- non-smooth optimal control problems (1)
- nonfullerene acceptors (1)
- nonspecific alkaline-phosphae (1)
- non‐native plants (1)
- noradrenaline (1)
- norepinephrine transporter (1)
- novel therapies (1)
- nuclear magnetic resonance spectroscopy (1)
- nuclear medicine (1)
- nuclear receptors (1)
- nucleation-elongation (1)
- nucleophilic addition (1)
- nucleophilic aromatic substitution (1)
- nucleoside modification recognition (1)
- nucleotide excision repair (1)
- number of interactions (1)
- nutrients (1)
- nutrition therapy (1)
- nutritional adaptations (1)
- nutritional composition (1)
- oak wood (1)
- oak wood extract (1)
- obesity (1)
- obinutuzumab (1)
- object-based classification (1)
- obliteration (1)
- observational cohort study (1)
- occurrence (1)
- oil palm (1)
- oil palm plantations (1)
- olfaction (1)
- olfactory bulb neurogenesis (1)
- oligodendroglia (1)
- ollimator (1)
- oncolytic virus (1)
- one‐lung ventilation (1)
- online systems (1)
- ontactin 1 (1)
- open spaces (1)
- operationalism (1)
- operative principle (1)
- opioid (1)
- opioid ligands (1)
- opioid receptors (1)
- opioids (1)
- oppositional defiant disorder (1)
- optical (1)
- optical tracts (1)
- optimal control (1)
- optimization (1)
- optogenetics (1)
- oral anticoagulants (1)
- oral hygiene (1)
- organ-on-a-chip (1)
- organic and inorganic synthesis (1)
- organic cation transporter (1)
- organic semiconductors (1)
- organic thin‐film transistors (1)
- organohalide respiration (1)
- organoid (1)
- orodental health (1)
- orosomucoid (1)
- oro‐facial pain (1)
- orthopaedic patients (1)
- orylation (1)
- osmotic adaptation (1)
- osteoblasts (1)
- osteocalcin (1)
- osteocyte network (1)
- osteogenic (1)
- osteogenic differentiation (1)
- osteokines adaptation (1)
- osteomalacia (1)
- osteopenia (1)
- other radiation exposure (atomic bombing/nuclear accidents) (1)
- out-of-hospital cardiac arrest (1)
- outcome (1)
- outcomes (1)
- outgrowth endothelial cells (1)
- output elasicities (1)
- output elasticities (1)
- ovariectomy (1)
- overweight (1)
- ow-cost photometer (1)
- oxidative addition (1)
- oxidative phosphorylation (1)
- oxidative stress (1)
- oxidised lipids (1)
- oxygen/glucose deprivation (1)
- p57kip2 (1)
- package (1)
- pain ratings (1)
- pain regulation (1)
- paleogeography (1)
- pamidronate (1)
- pancreatectomy (1)
- pandemia (1)
- pantanal wetland (1)
- paralogs (1)
- parasitoids (1)
- passes (1)
- pastoral care (1)
- pasture (1)
- pathogen (1)
- pathogenesis (1)
- pathophysiology (1)
- patient participation (1)
- patient-reported outcome (1)
- patient-specific knee arthroplasty (1)
- pattern (1)
- paxilline (1)
- pediatric low‐grade glioma (1)
- pediatrics (1)
- pelciv fracture (1)
- pelvic ring (1)
- pemphigus foliaceus (1)
- pemphigus vulgaris (1)
- penicillin allergy (1)
- penicillin hypersensitivity (1)
- peptide conjugates (1)
- peptide conjugation (1)
- percent depth dose curves (1)
- perceptual long-term memory (1)
- perennial ryegrass (1)
- perfluoroalkyl (1)
- performance assessment (1)
- performance prediction (1)
- perioperative care (1)
- periperal nerve (1)
- peripheral nervous system (1)
- peripheral-blood lymphocytes (1)
- periprosthetic infection (1)
- perivascular epitheloid cell tumour (1)
- permanent (1)
- peroxide containing copolymers (1)
- personalised medicine (1)
- personality (1)
- personalized training (1)
- perspective taking (1)
- perylene bisimides (1)
- perylene bismide dye (1)
- perylene imide (1)
- pest control (1)
- pest species (1)
- phagocytosis (1)
- phase-change (1)
- phase-contrast MRI (1)
- phenethylguanidine (1)
- phenotype (1)
- phenotype prediction (1)
- phosphatidylethanolamine (1)
- phosphatidylserine (1)
- phosphatidylserine transport (1)
- phosphoantigen (1)
- phosphodiesterases (PDEs) (1)
- photo app (1)
- photoisomerization (1)
- photosensitization (1)
- phylogenetic trees (1)
- phylogeny of osmolyte biosynthesis (1)
- physical activity trajectories (1)
- physical chemistry (1)
- physical performance (1)
- physician feedback (1)
- pilot project (1)
- plant bacteria (1)
- plant composition (1)
- plant fresh/dry weight (1)
- plant photoassimilate partitioning (1)
- plant–bee visitation networks (1)
- platelet disorders (1)
- platelet physiology (1)
- platinum (1)
- plausibility (1)
- pneumonia (1)
- point of care testing (1)
- polarized cell culture (1)
- polarized epithelium (1)
- polarized training (1)
- polarizing optical microscopy (1)
- political discourse (1)
- politics (1)
- pollen (1)
- pollen and nectar resources (1)
- pollen provisions (1)
- pollen quality (1)
- pollination (1)
- pollinator attraction (1)
- pollinator friendly plants (1)
- poly(2- oxazoline) (1)
- poly(2-ethyl-2-oxazoline) (1)
- poly(2-oxazine) (1)
- poly(ADP-ribosyl)ation (1)
- polycationic peptides (1)
- polycyclic aromatic hydrocarbon (1)
- polycyclic aromatic hydrocarbons (1)
- polymer thermoelectrics (1)
- polymer-analogue functionalization (1)
- polymerization (1)
- polyomavirus (1)
- polyoxazoline (1)
- polyphenols (1)
- polyploidy (1)
- polyvinylidene fluoride (PVDF) (1)
- population characteristics (1)
- population dynamics (1)
- porcine large animal model (1)
- pore formation (1)
- post-classification comparison (1)
- post-operative recovery (1)
- post-reconstruction filtering (1)
- post-surgery recovery (1)
- post-transcriptional regulation (1)
- postmodernism (1)
- postmortem studies (1)
- postoperative bleeding (1)
- postoperative complications (1)
- posttranslational modifications (1)
- postural control (1)
- power consumption (1)
- pre-clinical models (1)
- pre-crosslinking (1)
- precision training (1)
- preclinical drug discovery (1)
- precursor cells (1)
- prediction model (1)
- predictive factors (1)
- predictive marker (1)
- pregnancy (1)
- preoperative anaemia management (1)
- pressurized microwave‐assisted extraction (1)
- preterm children (1)
- preterm infants (1)
- prevention (1)
- primary antibody deficiency (1)
- primary bone marrow presentation (1)
- primary care (1)
- primary cell culture (1)
- primary immunodeficiencies (1)
- primeval forest (1)
- principle of inversion (1)
- printability (1)
- pro-angiogenic (1)
- probiotic prophylaxis (1)
- probiotics (1)
- process model (1)
- process model comprehension (1)
- processing pipeline (1)
- prodromal (1)
- productivity (1)
- productivity hypothesis (1)
- prognosis (1)
- prognostic factors (1)
- prognostic-biomarkers (1)
- progressive ataxia (1)
- progressive multiple sclerosis (1)
- projection neurons (1)
- proliferation (1)
- promotes (1)
- prophylaxis (1)
- proppins (1)
- proprioceptive drift (1)
- prosocial behavior (1)
- prospective studies (1)
- prostaglandin E2 (1)
- prostate-specific membrane antigen (1)
- prostate-specific membrane antigen (PSMA) (1)
- prostatic neoplasms (1)
- protease (1)
- protein (1)
- protein kinases (1)
- protein structures (1)
- protein synthesis (1)
- proteome (1)
- proteomic (1)
- proteomic signature (1)
- protocadherin gamma C3 (1)
- protozoa infections (1)
- pseudofractures (1)
- psychischer Stress (1)
- psychoactive massage (1)
- psychological distress (1)
- psychological modulation of pain (1)
- public health (1)
- pulmonary embolism (1)
- pulmonary function tests (1)
- pulmonary immune response (1)
- pulmonary surgical procedures (1)
- pulp canal calcification (1)
- pupil size (1)
- purinergic receptors (1)
- pyridoxal phosphatase (1)
- pyrolysis (1)
- quadcopters (1)
- quaility indicator (1)
- quality evaluation (1)
- quantitative stigmergy (1)
- quantum chemistry (1)
- quantum communication (1)
- quantum dots (1)
- quantum repeaters (1)
- question prompt list (1)
- radical anion (1)
- radical crosslinking (1)
- radical reactions (1)
- radicals (1)
- radiofrequency identification (1)
- radiogenomics (1)
- radioiodine therapy (1)
- radioligand therapy (1)
- randomised controlled trial (1)
- rapid prototyping (1)
- rare bone disease (1)
- rates (1)
- rational drug design (1)
- reabsorption (1)
- reactive electrophilic species (1)
- real time PCR (1)
- real-world evidence (1)
- realism (1)
- rearrangements (1)
- recent origin (1)
- recessive inheritance (1)
- recognition nexus domain (1)
- recommendation engine (1)
- rectal cancer (1)
- rectal resection (1)
- recurrent prostate cancer (1)
- redox homeostasis (1)
- reerse shoulder arthoplasty (1)
- reference architecture (1)
- refractive surgery (1)
- refugee (1)
- regenerative medicine (1)
- regenerative research (1)
- regional heterogeneity (1)
- regional species pool (1)
- regulation (1)
- regulator (1)
- regulatory T cells (1)
- rehabilitation (1)
- reinnervation (1)
- relationship satisfaction (1)
- relaxation (1)
- relaxometry (1)
- release (1)
- reliability (1)
- religion (1)
- renal cell carcinoma (1)
- renewable fuels (1)
- repeated (1)
- repetitive firing (1)
- replica (1)
- reproducible outcome measure (1)
- reproductive performance (1)
- research (1)
- research activity (1)
- resident CD34-positive cells (1)
- resistance exercise (1)
- resistance-breaking properties (1)
- resource use (1)
- resources (1)
- respiratory chain (1)
- respiratory distress syndrome (RDS) (1)
- respiratory infection (1)
- responses (1)
- responsibility (1)
- restoration strategy (1)
- resuscitation (1)
- resuscitation time (1)
- resveratrol (1)
- retaliation (1)
- reticulocyte haemoglobin (1)
- retinol‐binding protein 4 (1)
- reveals (1)
- revision arthroplasty (1)
- re‐transplantation (1)
- rheology (1)
- rheumatoid arhritis (1)
- rhinitis (1)
- ribozymes (1)
- rickets (1)
- ridge preservation (1)
- ring expansion (1)
- risk (1)
- risk factors (1)
- risk prediction (1)
- river discharge (1)
- robotic complications (1)
- robotic hysterectomy (1)
- robotic sacrocolpopexy (1)
- robotic surgery (1)
- robust change vector analysis (1)
- robustness (1)
- romantic relationship (1)
- root canal treatment (1)
- root morphology (1)
- roots (1)
- ruthenium bda complexes (1)
- sRNA atlas (1)
- saccades (1)
- sacral nerve stimulation (1)
- sacral neuromodulation (1)
- salivary gland (1)
- salt (1)
- salt stress (1)
- salvage logging (1)
- sanders (1)
- sandfish (1)
- saproxylic species (1)
- sapwood (1)
- sarcotubular myopathy (1)
- sasculature (1)
- satellite DNA (1)
- satellite data (1)
- scaffolds (1)
- scalability (1)
- scanner (1)
- schizophrenia (1)
- scoping review (1)
- screw (1)
- seagrass (1)
- seasonal phenology (1)
- second primary malignancy (1)
- secondary invader (1)
- secondary site infection (1)
- secretome (1)
- sectoral planning (1)
- self help (1)
- self-adaptive (1)
- self-aware computing systems (1)
- self-managing systems (1)
- self-monitoring (1)
- self-perception of psychology (1)
- self-regulation (1)
- self-renewal (1)
- self‐gated (1)
- semiconductors (1)
- semilinear elliptic operators (1)
- semi‐natural habitats (1)
- senescence (1)
- sensor (1)
- sensor networks (1)
- sensors (1)
- sentence comprehension (1)
- sentinel-2 (1)
- sepsis (1)
- series Discolores (1)
- serious mental illness (1)
- serjanic acid (1)
- serology (1)
- serotonin (1)
- serotonin receptors (1)
- serum biomarkers (1)
- sex differences (1)
- shaken baby syndrome (1)
- shape (1)
- shape fidelity (1)
- shape-amphiphiles (1)
- shape-truncation functions (1)
- shared‐reading (1)
- shear viscosity (1)
- shocks (1)
- shoot apical meristem (1)
- shooting injuries (1)
- short‐term scaling exponent (1)
- shoulder arthroplasty (1)
- shoulder infection (1)
- shoulder neurolysis (1)
- sialylation (1)
- signal peptide (1)
- signaling (1)
- signaling pathways (1)
- simulator sickness (1)
- single cell RNA sequencing (1)
- single crystal structure (1)
- single-molecule microscopy (1)
- single‐cell RNA‐seq (1)
- site-specific RNA cleavage (1)
- site-specific RNA labeling (1)
- skeletal (1)
- skeletal muscle (1)
- skin punch biopsy (1)
- sleep bruxism (1)
- slip (1)
- slit membrane (1)
- small RNA (1)
- small animal SPECT (1)
- small bowel bleeding (1)
- small fiber neuropathy (1)
- small intestine (1)
- small-animal imaging (1)
- small-molecule activation (1)
- smart mobile devices (1)
- smoldering myeloma (1)
- soccer (1)
- social (1)
- social behavior (1)
- social cognition (1)
- social dominance (1)
- social influence (1)
- social interaction (1)
- social media (1)
- social recognition (1)
- social status (1)
- sociality (1)
- social‐cognitive theory (1)
- socket preservation (1)
- software (1)
- software engineering (1)
- solar fuels (1)
- soldiers (1)
- solid-state NMR (1)
- solid-state emitters (1)
- solid-state sturcture (1)
- solubility (1)
- solution scattering (1)
- somatosensory feedback (1)
- sortase A (1)
- sourcing (1)
- spacer (1)
- spastic (1)
- spatial binding (1)
- spatial planning; sustainable development; cross-border coordination (1)
- spatial variation (1)
- spatio‐temporal data (1)
- specialization (1)
- species energy theory (1)
- species richness (1)
- species traits (1)
- species turnover (1)
- speckle tracking (1)
- spelling (1)
- sphingolipid expansion microscopy (1)
- sphingolipids (1)
- sphingosine (1)
- sphingosine kinases (1)
- spider phobia (1)
- spiders (1)
- spinal cord (1)
- spinal cord injury (1)
- splicing (1)
- split-belt treadmill (1)
- sporidia (1)
- squamous cell carcinoma (1)
- stab wounds (1)
- star-shaped compounds (1)
- startle reaction (1)
- state constraints (1)
- state space (1)
- statistical mechanics (1)
- statistical modeling (1)
- stem cell transplantation (1)
- stem-cell-triggered immunity (1)
- stenosis (1)
- stepped impedance resonators (1)
- stereolithography (1)
- stereotactic radiotherapy (1)
- sterubin (1)
- stochastic processes (1)
- stokes shift (1)
- stomata (1)
- storybooks (1)
- strategy (1)
- stratification (1)
- stream processing (1)
- strength and difficulties (1)
- stress level (1)
- stroma (1)
- structural basis (1)
- structural biology (1)
- structural modification (1)
- structural synaptic plasticity (1)
- structure probes (1)
- structure probing (1)
- structured illumination microscope (1)
- structure–property relation (1)
- study design (1)
- sturgeon (1)
- sturgeon karyotype (1)
- sub-Saharan Africa (1)
- subcellular trafficking (1)
- substance abuse disorder (1)
- substance-P (1)
- substantia nigra pars compacta (1)
- subthreshold bipolar (1)
- subunit (1)
- subventricular zone (1)
- successional trajectory (1)
- sucrose responsiveness (1)
- sudden death (1)
- sugar beet (1)
- sugar transport protein (1)
- sulforaphane (1)
- sulfur (1)
- sun exposure (1)
- superconductivity (1)
- supercritical CO<sub>2</sub> (1)
- superior (1)
- support vector machine (1)
- supraglacial lakes (1)
- supramolecular materials (1)
- suprascapular notch (1)
- surface melt (1)
- surface roughness (1)
- surgical care (1)
- surveillance (1)
- survey (1)
- sustainable (1)
- sustained inflammation (1)
- sustained lung inflation (SLI) (1)
- sustained release (1)
- swallow-tail (1)
- switch (1)
- switching navigation (1)
- synapse (1)
- synaptic plasticity (1)
- synaptic vesicles (1)
- synaptosomes (1)
- synthesis design (1)
- synthetic hydrogels (1)
- system inference (1)
- systematic review and meta-analysis (1)
- t-lymphocytes (1)
- tactile (1)
- tactually evoked potentials (1)
- tandem repeats (1)
- target (1)
- target therapies (1)
- targeted gene panel (1)
- targeted therapy (1)
- targeting (1)
- task dependency (1)
- task design (1)
- taste (1)
- taurodontism (1)
- taxonomy (1)
- teaching (1)
- teeth (1)
- telescope (1)
- temperature (1)
- temperature dependence of reaction rate (1)
- temperature dependency (1)
- temperature-speciation hypothesis (1)
- template (1)
- temporal variation (1)
- temporomandibular disorders (1)
- température (1)
- tenofovir (1)
- terror attack (1)
- terror attack trauma (1)
- tetrachloroethene (1)
- text comprehension (1)
- text-quality (1)
- the Mediterranean Sea (1)
- theology (1)
- theory of mind (1)
- theranostic markers (1)
- theranostics (1)
- therapeutic medical radiation exposure (EBRT/ RAI) (1)
- therapeutic potential (1)
- thermal crosslinking (1)
- thermal infrared (1)
- thermal variation (1)
- theta (1)
- thin sections (1)
- third (1)
- third party dictator game (1)
- thrombemboli (1)
- thromboembolism (1)
- thrombolysis (1)
- thrust direction (1)
- thrust moraine (1)
- thymine (1)
- thyroid (1)
- tight junctions (1)
- time (1)
- time calibration (1)
- time-series features (1)
- tinnitus research (1)
- tinnitus therapy (1)
- tissue engineering (1)
- tocilizumab (IL-6 inhibitor) (1)
- topolectrical circuits (1)
- torsinA (1)
- total knee replacement (1)
- total lesion PSMA (1)
- total lesion glycolysis (TLG) (1)
- total lesion methionine uptake (TLMU) (1)
- trabectome (1)
- trabecular bypass stent (1)
- training (1)
- trait mindfulness (1)
- tranexamic acid (1)
- transceiver array (1)
- transcription factor (1)
- transcription factors (1)
- transcription start sites (1)
- transcriptomics (1)
- translation (1)
- translation initiation (1)
- translational (1)
- translocation (1)
- transmission electron microscopy (1)
- transpiration (1)
- transport (1)
- trapped atoms/ions (1)
- trauma (1)
- trauma centre (1)
- trauma management (1)
- trend analysis (1)
- triarylamine (1)
- triarylborane (1)
- triboranes (1)
- trophic factors (1)
- trophic levels (1)
- trophic position (1)
- tropocoronands (1)
- trypanosoma brucei (1)
- tryptophan (1)
- tubulin (1)
- tubulin-binding cofactors (1)
- tumor heterogeneity (1)
- tumor necrosis factor-α (1)
- tumor-associated macrophage (1)
- tumor-infiltrating (1)
- tumor-specific CD8+ T cells (1)
- tumor‐specific antigen (1)
- tumour malignancy (1)
- two stage (1)
- two‐component system (1)
- type 1 (1)
- type 2 diabetes (1)
- ultrasound (1)
- ultrastructure (1)
- ultraviolet photoelectron spectroscopy (1)
- undergraduate training (1)
- unexpressed needs (1)
- unmanned aerial vehicles (1)
- unreflective actions (1)
- uper-resolution array tomography (1)
- urinary tract infection (UTI) (1)
- urolithins (1)
- uropathogens (1)
- usability study (1)
- use intensity (1)
- user model (1)
- user study (1)
- vaccinia virus (1)
- vacuolar myopathy (1)
- validation (1)
- value-distribution (1)
- van‘t Hoff rule (1)
- variability (1)
- variational estimation (1)
- vascular plants (1)
- vehicular navigation (1)
- venetoclax (1)
- ventricular zone (1)
- venturesomeness (1)
- vertebrate (1)
- vertebrate scavenger (1)
- vertebrobasilar insufficiency (1)
- vertebrobasilar stroke (1)
- vertigo (1)
- vestibular schwannoma (1)
- video QoE (1)
- video capsule endoscopy (1)
- video-based analyses (1)
- violence (1)
- viral load (1)
- virtual reality (1)
- virulence (1)
- vision (1)
- visual long-term memory (1)
- vitamin B6 (1)
- vitamin D deficiency (1)
- vitamin k deficiency bleeding (1)
- walking (1)
- walking phase (1)
- warfarin interruption (1)
- wasps (1)
- water availability (1)
- water beetles (1)
- water dynamics (1)
- water management (1)
- water oxidation (1)
- water purification (1)
- water splitting (1)
- wave‐CAIPI (1)
- weakly coordinating anions (1)
- weibliche Autoren (1)
- wetland (1)
- wheelchair control (1)
- whole exome sequencing (1)
- whole genome duplication (1)
- whole-genome duplication (1)
- wild bees (1)
- wildlife management (1)
- windthrow (1)
- winter wheat (1)
- woody plant richness (1)
- wood‐inhabiting fungi (1)
- worker behavior (1)
- workplace (1)
- xenophagy (1)
- xerostomia (1)
- xylylene (1)
- yam (1)
- yield (1)
- young females (1)
- youth (1)
- youth soccer (1)
- zinc oxide nanoparticles (1)
- zonal (1)
- zooxanthellae (1)
- Österreich (1)
- Überzeugungen (1)
- α-Cell (1)
- α-Ketoglutarate dehydrogenase (1)
- α‐GalA 3D‐structure (1)
- β-Cell (1)
- β-diversity (1)
- β1-adrenoceptor/β1-adrenergic receptor (1)
- γ-H2AX (1)
- γδ T cell (1)
- γδ TCR (1)
- π aromaticity (1)
- π-Aromatizität (1)
- π-complex (1)
- π-π-interactions (1)
- ∆Np63 (1)
Institut
- Theodor-Boveri-Institut für Biowissenschaften (99)
- Medizinische Klinik und Poliklinik II (45)
- Institut für Anorganische Chemie (38)
- Neurologische Klinik und Poliklinik (32)
- Institut für Organische Chemie (29)
- Klinik und Poliklinik für Anästhesiologie (ab 2004) (26)
- Institut für Psychologie (24)
- Institut für Geographie und Geologie (23)
- Institut für Klinische Epidemiologie und Biometrie (22)
- Institut für diagnostische und interventionelle Radiologie (Institut für Röntgendiagnostik) (22)
Sonstige beteiligte Institutionen
- Agricultural Center, BASF SE, 67117 Limburgerhof, Germany (1)
- Core Unit Systemmedizin (1)
- Institute of Organic Chemistry and Center for Molecular Biosciences Innsbruck, CMBI, Leopold-Franzens University Innsbruck, Austria (1)
- Interdisciplinary Center for Clinical Research (1)
- Mildred Scheel Early Career Center (1)
- Paul Scherrer Institut (1)
Hydrogels that can mimic mechanical properties and functions of biological tissue have attracted great interest in tissue engineering and biofabrication. In these fields, new materials and approaches to prepare hydrogels without using toxic starting materials or materials that decompose into toxic compounds remain to be sought after. Here, we report the crosslinking of commercial, unfunctionalized hydrophilic poly(2-ethyl-2-oxazoline) using peroxide copolymers in their melt. The influence of temperature, peroxide copolymer concentration, and duration of the crosslinking process has been investigated. The method allows to create hydrogels from unfunctionalized polymers in their melt and to control the mechanical properties of the resulting materials. The design of hydrogels with a suitable mechanical performance is of crucial importance in many existing and potential applications of soft materials, including medical applications.
Der vorliegende Beitrag beschreibt die praxis- und theorieorientierte Entwicklung und Evaluation eines fächerübergreifenden Unterrichtskonzepts für die zehnte Jahrgangstufe an Gymnasien zur Förderung propagandaspezifischer Medienkritik- und Analysefähigkeit. Infolge der Aufarbeitung empirischer und theoretischer Grundlagen zum Propagandabegriff und zur Medienkritikfähigkeit wurde basierend auf den Annahmen einer handlungs- und entwicklungsorientierten Didaktik ein medienpädagogisches Unterrichtskonzept ausgearbeitet. Unter Verwendung eines weit gefassten Propagandabegriffs wurden Propagandabeispiele in historisch vergleichender Perspektive analysiert und beurteilt, bevor die Gestaltung eigener Counter Narratives als mögliche Gegenmassnahme umgesetzt wurde. Neben seiner besonderen Bedeutung als theoretischer Bezugspunkt war der Ansatz der digital and media literacy von Hobbs (2011) aufgrund der propagandaspezifischen Bezüge handlungsleitend bei der Entwicklung des mixed-methods Untersuchungsdesigns. Die Ergebnisse der quasi-experimentellen Evaluation bestätigen die Wirksamkeit der Intervention sowohl hinsichtlich der Förderung einer allgemeinen Medienkritikfähigkeit als auch einer propagandaspezifischen Analysefähigkeit.
Verschwörungstheorien und Onlinepropaganda treten vielfältig und zahlreich in der Medienlandschaft auf. Die Gestaltung von Counter-Narrativen bietet ein hohes Potenzial, den kritischen Umgang von Jugendlichen mit medialen Beeinflussungs- und Steuerungsversuchen zu fördern. Basierend auf einer gestaltungsorientierten Bildungsforschung werden in diesem Beitrag theoretische Grundlagen zur Mediengestaltung unter medienkritischer Perspektive sowie zu Counter-Narrativen aufgearbeitet, bevor ein auf den Annahmen der handlungs- und entwicklungsorientierten Didaktik entwickeltes Unterrichtskonzept zur Gestaltung von Counter-Narrativen dargestellt wird. Im Rahmen eines qualitativen Untersuchungsdesigns wurden die gestalteten Beiträge hinsichtlich ihrer Medienmerkmale, medienkritischer Implikationen und Narrativitätsfaktoren inhaltsanalytisch ausgewertet. Die Analyse der Medienmerkmale verweist z.B. auf den re-kontextualisierenden Charakter schriftlicher Texte für bild- und symbolhafte Darstellungen. Überdies konnten medienkritische Praktiken unabhängig vom jeweiligen Grad der Narrativität identifiziert werden.
Five compounds containing boron–boron multiple bonds are shown to undergo hydrophosphination reactions with diphenylphosphine in the absence of a catalyst. With diborenes, the products obtained are highly dependent on the substitution pattern at the boron atoms, with both 1,1- and 1,2- hydrophosphinations observed. With a symmetrical diboryne, 1,2-hydrophosphination yields a hydro(phosphino)diborene. The different mechanistic pathways for the hydrophosphination of diborenes are rationalised with the aid of density functional theory calculations.
Bioprinting has emerged as a valuable threedimensional (3D) biomanufacturing method to fabricate complex hierarchical cell-containing constructs. Spanning from basic research to clinical translation, sterile starting materials are crucial. In this study, we present pharmacopeia compendial sterilization methods for the commonly used bioink component alginate. Autoclaving (sterilization in saturated steam) and sterile filtration followed by lyophilization as well as the pharmacopeia non-compendial method, ultraviolet (UV)-irradiation for disinfection, were assessed. The impact of the sterilization methods and their effects on physicochemical and rheological properties, bioprinting outcome, and sterilization efficiency of alginate were detailed. Only sterile filtration followed by lyophilization as the sterilization method retained alginate's physicochemical properties and bioprinting behavior while resulting in a sterile outcome. This set of methods provides a blueprint for the analysis of sterilization effects on the rheological and physicochemical pattern of bioink components and is easily adjustable for other polymers used in the field of biofabrication in the future.
An Overview of Design Patterns for Self-Adaptive Systems in the Context of the Internet of Things
(2020)
The Internet of Things (IoT) requires the integration of all available, highly specialized, and heterogeneous devices, ranging from embedded sensor nodes to servers in the cloud. The self-adaptive research domain provides adaptive capabilities that can support the integration in IoT systems. However, developing such systems is a challenging, error-prone, and time-consuming task. In this context, design patterns propose already used and optimized solutions to specific problems in various contexts. Applying design patterns might help to reuse existing knowledge about similar development issues. However, so far, there is a lack of taxonomies on design patterns for self-adaptive systems. To tackle this issue, in this paper, we provide a taxonomy on design patterns for self-adaptive systems that can be transferred to support adaptivity in IoT systems. Besides describing the taxonomy and the design patterns, we discuss their applicability in an Industrial IoT case study.
Purpose
Pronounced differences in individual physiological adaptation may occur following various training mesocycles in runners. Here we aimed to assess the individual changes in performance and physiological adaptation of recreational runners performing mesocycles with different intensity, duration and frequency.
Methods
Employing a randomized cross-over design, the intra-individual physiological responses [i.e., peak (\(\dot{VO}_{2peak}\)) and submaximal (\(\dot{VO}_{2submax}\)) oxygen uptake, velocity at lactate thresholds (V\(_2\), V\(_4\))] and performance (time-to-exhaustion (TTE)) of 13 recreational runners who performed three 3-week sessions of high-intensity interval training (HIIT), high-volume low-intensity training (HVLIT) or more but shorter sessions of HVLIT (high-frequency training; HFT) were assessed.
Results
\(\dot{VO}_{2submax}\), V\(_2\), V\(_4\) and TTE were not altered by HIIT, HVLIT or HFT (p > 0.05). \(\dot{VO}_{2peak}\) improved to the same extent following HVLIT (p = 0.045) and HFT (p = 0.02). The number of moderately negative responders was higher following HIIT (15.4%); and HFT (15.4%) than HVLIT (7.6%). The number of very positive responders was higher following HVLIT (38.5%) than HFT (23%) or HIIT (7.7%). 46% of the runners responded positively to two mesocycles, while 23% did not respond to any.
Conclusion
On a group level, none of the interventions altered \(\dot{VO}_{2submax}\), V\(_2\), V\(_4\) or TTE, while HVLIT and HFT improved \(\dot{VO}_{2peak}\). The mean adaptation index indicated similar numbers of positive, negative and non-responders to HIIT, HVLIT and HFT, but more very positive responders to HVLIT than HFT or HIIT. 46% responded positively to two mesocycles, while 23% did not respond to any. These findings indicate that the magnitude of responses to HIIT, HVLIT and HFT is highly individual and no pattern was apparent.
Editorial
(2020)
No abstract available.
Head and neck squamous cell carcinoma (HNSCC) is known to overexpress a variety of receptor tyrosine kinases, such as the HGF receptor Met. Like other malignancies, HNSCC involves a mutual interaction between the tumor cells and surrounding tissues and cells. We hypothesized that activation of HGF/Met signaling in HNSCC influences glucose metabolism and therefore substantially changes the tumor microenvironment. To determine the effect of HGF, we submitted three established HNSCC cell lines to mRNA sequencing. Dynamic changes in glucose metabolism were measured in real time by an extracellular flux analyzer. As expected, the cell lines exhibited different levels of Met and responded differently to HGF stimulation. As confirmed by mRNA sequencing, the level of Met expression was associated with the number of upregulated HGF-dependent genes. Overall, Met stimulation by HGF leads to increased glycolysis, presumably mediated by higher expression of three key enzymes of glycolysis. These effects appear to be stronger in Met\(^{high}\)-expressing HNSCC cells. Collectively, our data support the hypothesized role of HGF/Met signaling in metabolic reprogramming of HNSCC.
Aims Acute myocardial infarction (MI) is the major cause of chronic heart failure. The activity of blood coagulation factor XIII (FXIIIa) plays an important role in rodents as a healing factor after MI, whereas its role in healing and remodelling processes in humans remains unclear. We prospectively evaluated the relevance of FXIIIa after acute MI as a potential early prognostic marker for adequate healing.
Methods and results This monocentric prospective cohort study investigated cardiac remodelling in patients with ST-elevation MI and followed them up for 1 year. Serum FXIIIa was serially assessed during the first 9 days after MI and after 2, 6, and 12 months. Cardiac magnetic resonance imaging was performed within 4 days after MI (Scan 1), after 7 to 9 days (Scan 2), and after 12 months (Scan 3). The FXIII valine-to-leucine (V34L) single-nucleotide polymorphism rs5985 was genotyped. One hundred forty-six patients were investigated (mean age 58 ± 11 years, 13% women). Median FXIIIa was 118 % (quartiles, 102–132%) and dropped to a trough on the second day after MI: 109%(98–109%; P < 0.001). FXIIIa recovered slowly over time, reaching the baseline level after 2 to 6 months and surpassed baseline levels only after 12 months: 124 % (110–142%). The development of FXIIIa after MI was independent of the genotype. FXIIIa on Day 2 was strongly and inversely associated with the relative size of MI in Scan 1 (Spearman’s ρ = –0.31; P = 0.01) and Scan 3 (ρ = –0.39; P < 0.01) and positively associated with left ventricular ejection fraction: ρ = 0.32 (P < 0.01) and ρ = 0.24 (P = 0.04), respectively.
Conclusions FXIII activity after MI is highly dynamic, exhibiting a significant decline in the early healing period, with reconstitution 6 months later. Depressed FXIIIa early after MI predicted a greater size of MI and lower left ventricular ejection fraction after 1 year. The clinical relevance of these findings awaits to be tested in a randomized trial.
The second messengers, cyclic adenosine 3′-5′-monophosphate (cAMP) and cyclic guanosine 3′-5′-monophosphate (cGMP), play important roles in many animal cells by regulating intracellular signaling pathways and modulating cell physiology. Environmental cues like temperature, light, and chemical compounds can stimulate cell surface receptors and trigger the generation of second messengers and the following regulations. The spread of cAMP and cGMP is further shaped by cyclic nucleotide phosphodiesterases (PDEs) for orchestration of intracellular microdomain signaling. However, localized intracellular cAMP and cGMP signaling requires further investigation. Optogenetic manipulation of cAMP and cGMP offers new opportunities for spatio-temporally precise study of their signaling mechanism. Light-gated nucleotide cyclases are well developed and applied for cAMP/cGMP manipulation. Recently discovered rhodopsin phosphodiesterase genes from protists established a new and direct biological connection between light and PDEs. Light-regulated PDEs are under development, and of demand to complete the toolkit for cAMP/cGMP manipulation. In this review, we summarize the state of the art, pros and cons of artificial and natural light-regulated PDEs, and discuss potential new strategies of developing light-gated PDEs for optogenetic manipulation.
We here present the case of a 67-year-old woman with a history of a slowly progressive, polypous nodule on her left wrist. The lesion was excised, and the histological analysis revealed a clear cell tumour that was relatively sharply demarked from the surrounding tissue extending into the subcutaneous tissue. The tumour showed a characteristic trabecular pattern in which the tumour cells were arranged around numerous vessels. The neoplastic cells had a predominantly epithelioid shape, granular eosinophilic to clear cytoplasm and prominent centrally located nucleoli. The histological differential diagnosis included a metastatic clear-cell renal cell carcinoma and a primary cutaneous perivascular epithelioid cell tumour (PEComa). Immunohistochemically, the tumour cells revealed homogenous expression of HMB-45, MiTF and CD10, whereas MART-1 and S100 were negative. Antibodies against actin marked the trabecularly arranged vessels, and the neoplastic cells yielded a patchy positivity against actin and desmin. Additional immunohistochemical stains against pan-cytokeratin, CAIX, PAX-8 and EMA were negative. Based on the morphologic and immunophenotypic findings, the histological diagnosis of a CD10-positive cutaneous PEComa was made.
In enterocytes, protein RS1 (RSC1A1) mediates an increase of glucose absorption after ingestion of glucose-rich food via upregulation of Na+-D-glucose cotransporter SGLT1 in the brush-border membrane (BBM). Whereas RS1 decelerates the exocytotic pathway of vesicles containing SGLT1 at low glucose levels between meals, RS1-mediated deceleration is relieved after ingestion of glucose-rich food. Regulation of SGLT1 is mediated by RS1 domain RS1-Reg, in which Gln-Ser-Pro (QSP) is effective. In contrast to QSP and RS1-Reg, Gln-Glu-Pro (QEP) and RS1-Reg with a serine to glutamate exchange in the QSP motif downregulate the abundance of SGLT1 in the BBM at high intracellular glucose concentrations by about 50%. We investigated whether oral application of QEP improves diabetes in db/db mice and affects the induction of diabetes in New Zealand obese (NZO) mice under glucolipotoxic conditions. After 6-day administration of drinking water containing 5 mM QEP to db/db mice, fasting glucose was decreased, increase of blood glucose in the oral glucose tolerance test was blunted, and insulin sensitivity was increased. When QEP was added for several days to a high fat/high carbohydrate diet that induced diabetes in NZO mice, the increase of random plasma glucose was prevented, accompanied by lower plasma insulin levels. QEP is considered a lead compound for development of new antidiabetic drugs with more rapid cellular uptake. In contrast to SGLT1 inhibitors, QEP-based drugs may be applied in combination with insulin for the treatment of type 1 and type 2 diabetes, decreasing the required insulin amount, and thereby may reduce the risk of hypoglycemia.
Microbial, mammalian, and plant cells produce and contain secondary metabolites, which typically are soluble in water to prevent cell damage by crystallization. The formation of ion pairs, for example, with carboxylic acids or mineral acids, is a natural blueprint to maintain basic metabolites in solution. Here, we aim at showing whether the mostly large carboxylates form soluble protic ionic liquids (PILs) with the basic natural product papaverine resulting in enhanced aqueous solubility. The obtained PILs were characterized by H-1-N-15 HMBC nuclear magnetic resonance (NMR) and in the solid state using X-ray powder diffraction, differential scanning calorimetry, and dissolution measurements. Furthermore, their supramolecular pattern in aqueous solution was studied by means of potentiometric and photometrical solubility, NMR aggregation assay, dynamic light scattering, zeta potential, and viscosity measurements. Thereby, we identified the naturally occurring carboxylic acids, citric acid, malic acid, and tartaric acid, as being appropriate counterions for papaverine and which will facilitate the formation of PILs with their beneficial characteristics, like the improved dissolution rate and enhanced apparent solubility.
Protein inclusions containing the RNA-binding protein TDP-43 are a pathological hallmark of amyotrophic lateral sclerosis and other neurodegenerative disorders. The loss of TDP-43 function that is associated with these inclusions affects post-transcriptional processing of RNAs in multiple ways including pre-mRNA splicing, nucleocytoplasmic transport, modulation of mRNA stability and translation. In contrast, less is known about the role of TDP-43 in axonal RNA metabolism in motoneurons. Here we show that depletion of Tdp-43 in primary motoneurons affects axon growth. This defect is accompanied by subcellular transcriptome alterations in the axonal and somatodendritic compartment. The axonal localization of transcripts encoding components of the cytoskeleton, the translational machinery and transcripts involved in mitochondrial energy metabolism were particularly affected by loss of Tdp-43. Accordingly, we observed reduced protein synthesis and disturbed mitochondrial functions in axons of Tdp-43-depleted motoneurons. Treatment with nicotinamide rescued the axon growth defect associated with loss of Tdp-43. These results show that Tdp-43 depletion in motoneurons affects several pathways integral to axon health indicating that loss of TDP-43 function could thus make a major contribution to axonal pathomechanisms in ALS.
We report the generation, spectroscopic characterization, and computational analysis of the first free (non-stabilized) organometallic bismuthinidene, BiMe. The title compound was generated in situ from BiMe\(_3\) by controlled homolytic Bi–C bond cleavage in the gas phase. Its electronic structure was characterized by a combination of photoion mass-selected threshold photoelectron spectroscopy and DFT as well as multi-reference computations. A triplet ground state was identified and an ionization energy (IE) of 7.88 eV was experimentally determined. Methyl abstraction from BiMe\(_3\) to give [BiMe(_2\)]• is a key step in the generation of BiMe. We reaveal a bond dissociation energy of 210 ± 7 kJ mol\(^{−1}\), which is substantially higher than the previously accepted value. Nevertheless, the homolytic cleavage of Me–BiMe\(_2\) bonds could be achieved at moderate temperatures (60–120 °C) in the condensed phase, suggesting that [BiMe\(_2\)]• and BiMe are accessible as reactive intermediates under these conditions.
Forecasting spatio-temporal dynamics on the land surface using Earth Observation data — a review
(2020)
Reliable forecasts on the impacts of global change on the land surface are vital to inform the actions of policy and decision makers to mitigate consequences and secure livelihoods. Geospatial Earth Observation (EO) data from remote sensing satellites has been collected continuously for 40 years and has the potential to facilitate the spatio-temporal forecasting of land surface dynamics. In this review we compiled 143 papers on EO-based forecasting of all aspects of the land surface published in 16 high-ranking remote sensing journals within the past decade. We analyzed the literature regarding research focus, the spatial scope of the study, the forecasting method applied, as well as the temporal and technical properties of the input data. We categorized the identified forecasting methods according to their temporal forecasting mechanism and the type of input data. Time-lagged regressions which are predominantly used for crop yield forecasting and approaches based on Markov Chains for future land use and land cover simulation are the most established methods. The use of external climate projections allows the forecasting of numerical land surface parameters up to one hundred years into the future, while auto-regressive time series modeling can account for intra-annual variances. Machine learning methods have been increasingly used in all categories and multivariate modeling that integrates multiple data sources appears to be more popular than univariate auto-regressive modeling despite the availability of continuously expanding time series data. Regardless of the method, reliable EO-based forecasting requires high-level remote sensing data products and the resulting computational demand appears to be the main reason that most forecasts are conducted only on a local scale. In the upcoming years, however, we expect this to change with further advances in the field of machine learning, the publication of new global datasets, and the further establishment of cloud computing for data processing.
2,2′-Bipyridyl is shown to spontaneously abstract a borylene fragment (R–B:) from various hypovalent boron compounds. This process is a redox reaction in which the bipyridine is reduced and becomes a dianionic substituent bound to boron through its two nitrogen atoms. Various transition metal–borylene complexes and diboranes, as a well as a diborene, take part in this reaction. In the latter case, our results show an intriguing example of the homolytic cleavage of a B═B double bond.
Objective
Impairment of glycinergic neurotransmission leads to complex movement and behavioral disorders. Patients harboring glycine receptor autoantibodies suffer from stiff‐person syndrome or its severe variant progressive encephalomyelitis with rigidity and myoclonus. Enhanced receptor internalization was proposed as the common molecular mechanism upon autoantibody binding. Although functional impairment of glycine receptors following autoantibody binding has recently been investigated, it is still incompletely understood.
Methods
A cell‐based assay was used for positive sample evaluation. Glycine receptor function was assessed by electrophysiological recordings and radioligand binding assays. The in vivo passive transfer of patient autoantibodies was done using the zebrafish animal model.
Results
Glycine receptor function as assessed by glycine dose–response curves showed significantly decreased glycine potency in the presence of patient sera. Upon binding of autoantibodies from 2 patients, a decreased fraction of desensitized receptors was observed, whereas closing of the ion channel remained fast. The glycine receptor N‐terminal residues \(^{29}\)A to \(^{62}\)G were mapped as a common epitope of glycine receptor autoantibodies. An in vivo transfer into the zebrafish animal model generated a phenotype with disturbed escape behavior accompanied by a reduced number of glycine receptor clusters in the spinal cord of affected animals.
Interpretation
Autoantibodies against the extracellular domain mediate alterations of glycine receptor physiology. Moreover, our in vivo data demonstrate that the autoantibodies are a direct cause of the disease, because the transfer of human glycine receptor autoantibodies to zebrafish larvae generated impaired escape behavior in the animal model compatible with abnormal startle response in stiff‐person syndrome or progressive encephalitis with rigidity and myoclonus patients.
Background
Mesenchymal stem cell (MSC) based-treatments of cartilage injury are promising but impaired by high levels of hypertrophy after chondrogenic induction with several bone morphogenetic protein superfamily members (BMPs). As an alternative, this study investigates the chondrogenic induction of MSCs via adenoviral gene-delivery of the transcription factor SOX9 alone or in combination with other inducers, and comparatively explores the levels of hypertrophy and end stage differentiation in a pellet culture system in vitro.
Methods
First generation adenoviral vectors encoding SOX9, TGFB1 or IGF1 were used alone or in combination to transduce human bone marrow-derived MSCs at 5 x 10\(^2\) infectious particles/cell. Thereafter cells were placed in aggregates and maintained for three weeks in chondrogenic medium. Transgene expression was determined at the protein level (ELISA/Western blot), and aggregates were analysed histologically, immunohistochemically, biochemically and by RT-PCR for chondrogenesis and hypertrophy.
Results
SOX9 cDNA was superior to that encoding TGFB1, the typical gold standard, as an inducer of chondrogenesis in primary MSCs as evidenced by improved lacuna formation, proteoglycan and collagen type II staining, increased levels of GAG synthesis, and expression of mRNAs associated with chondrogenesis. Moreover, SOX9 modified aggregates showed a markedly lower tendency to progress towards hypertrophy, as judged by expression of the hypertrophy markers alkaline phosphatase, and collagen type X at the mRNA and protein levels.
Conclusion
Adenoviral SOX9 gene transfer induces chondrogenic differentiation of human primary MSCs in pellet culture more effectively than TGFB1 gene transfer with lower levels of chondrocyte hypertrophy after 3 weeks of in vitro culture. Such technology might enable the formation of more stable hyaline cartilage repair tissues in vivo.