Refine
Has Fulltext
- yes (393)
Year of publication
- 2017 (393) (remove)
Document Type
- Journal article (393) (remove)
Keywords
- Hadron-Hadron scattering (experiments) (28)
- High energy physics (26)
- medicine (14)
- Medicine (11)
- physics (11)
- biology (10)
- gene expression (8)
- high energy physics (8)
- inflammation (8)
- Higgs physics (5)
- multiple myeloma (5)
- Asthma (4)
- B cells (4)
- Beyond Standard Model (4)
- CXCR4 (4)
- Candida albicans (4)
- DNA methylation (4)
- NLO computations (4)
- PET (4)
- Top physics (4)
- Trypanosoma (4)
- ants (4)
- blood (4)
- chemistry (4)
- fungi (4)
- geography (4)
- monocytes (4)
- mouse model (4)
- regulatory T cells (4)
- social systems (4)
- Apis mellifera (3)
- Biology (3)
- Drosophila melanogaster (3)
- Large Hadron Collider (3)
- MRI (3)
- Magnetic resonance imaging (3)
- Parkinson’s disease (3)
- Physics (3)
- animal sociality (3)
- antifungals (3)
- apoptosis (3)
- breast cancer (3)
- cell differentiation (3)
- dendritic cells (3)
- genetics (3)
- hyperexpression techniques (3)
- ischemic stroke (3)
- learning (3)
- molecular medicine (3)
- mouse models (3)
- mutation (3)
- psychiatry (3)
- psychology (3)
- theranostics (3)
- AdS-CFT Correspondence (2)
- Aspergillus fumigatus (2)
- Bacterial pathogens (2)
- Burkina Faso (2)
- CNS (2)
- DNA damage (2)
- Drosophila (2)
- EAE (2)
- Electroweak interaction (2)
- FDG (2)
- Fabry disease (2)
- Higgs boson (2)
- IL-2 (2)
- NLO Computations (2)
- Neisseria meningitidis (2)
- Oxygen (2)
- P300 (2)
- PET/CT (2)
- Positronen-Emissions-Tomografie (2)
- Pulmonary imaging (2)
- Quality of life (2)
- RNA-sequencing (2)
- Rezension (2)
- Salmonellosis (2)
- Staphylococcus aureus (2)
- Supersymmetry (2)
- T cells (2)
- Tanzania (2)
- actinomycetes (2)
- alkaloids (2)
- amygdala (2)
- antibacterial activity (2)
- anxiety (2)
- athletes (2)
- attention (2)
- autophagy (2)
- biomarker (2)
- biophysics (2)
- brain (2)
- cancer risk factors (2)
- cancer treatment (2)
- carbon dioxide (2)
- case report (2)
- cell cycle and cell division (2)
- ceramide (2)
- chemotherapy (2)
- chronic kidney disease (2)
- colorectal cancer (2)
- comparative genomics (2)
- condensed matter physics (2)
- coronary heart disease (2)
- cortisol (2)
- cytotoxic T cells (2)
- depression (2)
- elderly (2)
- electronic properties and materials (2)
- epigenetics (2)
- evaluation (2)
- fibrosis (2)
- fluorescence imaging (2)
- foraging (2)
- fullerenes (2)
- fungal infection (2)
- gene regulation (2)
- genetic loci (2)
- genetic variation (2)
- genotoxicity (2)
- guideline adherence (2)
- hearing loss (2)
- heart (2)
- histology (2)
- holography and condensed matter physics (AdS/CMT) (2)
- humans (2)
- humidity (2)
- immune evasion (2)
- immunomodulation (2)
- in vitro (2)
- infection (2)
- lung cancer (2)
- macrophages (2)
- marine sponges (2)
- mechanotransduction (2)
- megakaryocytes (2)
- melanoma (2)
- memory (2)
- messenger RNA (2)
- metabolism (2)
- metagenomics (2)
- metastasis (2)
- methylation (2)
- mice (2)
- microRNAs (2)
- microbiology (2)
- mushroom bodies (2)
- nanophotonics and plasmonics (2)
- near-infrared spectroscopy (2)
- nesting habits (2)
- osteoarthritis (2)
- pediatric (2)
- protected areas (2)
- quantum wells (2)
- regulation (2)
- regulator genes (2)
- remote sensing (2)
- semiconductors (2)
- serotonin (2)
- signaling (2)
- small interfering RNAs (2)
- social features (2)
- structure elucidation (2)
- symbiosis (2)
- team sport (2)
- tight junctions (2)
- transcription factors (2)
- transcriptome (2)
- transition radiation (2)
- treatment (2)
- two-dimensional materials (2)
- validation (2)
- yellow fluorescent protein (2)
- (nonce) borrowing (1)
- 18F-DCFPL (1)
- 3-coordinate boron (1)
- 3D collation (1)
- 3D viewer (1)
- 4D flow cardiovascular magnetic resonance (1)
- 5-fluorouracil (1)
- A53T (1)
- ADAMTS (1)
- ALOS (1)
- ALOS-2 (1)
- ALS (1)
- ARIA (1)
- ATLAS detector (1)
- Accidental coincidence (1)
- Acute lymphoblastic leukemia (1)
- Acute myeloid leukemia (1)
- Acyrthosiphon pisum (1)
- AdS-CFT correspondence (1)
- Adrenocortical Carcinoma (1)
- Adults (1)
- Afghanistan (1)
- Africa (1)
- Agricultural soil science (1)
- Akutes Nierenversagen (1)
- Allergic rhinitis (1)
- Alpen (1)
- Alzheimer's disease (1)
- Alzheimer’s disease (1)
- Ancistrocladus ealaensis (1)
- Ancistrocladus likoko (1)
- Antibacterial therapy (1)
- Antibacterials (1)
- Antibiotic resistance (1)
- Antibiotics (1)
- Antisense (1)
- Aorta (1)
- Apicomplexan (1)
- ApoE\(^{(-/-)}\) (1)
- Arbeitsgemeinschaft Linguistische Pragmatik (1)
- Arctic (1)
- Atherosclerosis (1)
- Atlantischer Wildkohl (1)
- Attitude Heading Reference System (AHRS) (1)
- Autoimmunity (1)
- Aviophobia (1)
- B cell receptors (1)
- B physics (1)
- B7-H1 (1)
- BBC3 (1)
- BCI (1)
- BDNF (1)
- BIRC7 (1)
- BMP (1)
- BMP-2 (1)
- Bacteriaophage AR9 (1)
- Bataille (1)
- Batf3 (1)
- Beauzée (1)
- Becker naevus (1)
- Becker naevus syndrome (1)
- Berchtesgaden NP (1)
- Birds (1)
- Body composition (1)
- Bone health (1)
- Bone marrow transplantation (1)
- Brain μ-opioid receptors (1)
- Brassica oleracea (1)
- Breathing (1)
- Brombeerart (1)
- Brombeere (1)
- Burmese Days (1)
- CBF (1)
- CCN2 (1)
- CD28 (1)
- CD4\(^{+}\) T cells (1)
- CHRODIS (1)
- CLIP-seq (1)
- CLN3 (1)
- CMV (1)
- CNV (1)
- CTGF (1)
- Ca\(_{v}\)2.2 (1)
- Caenorhabditis elegans (1)
- Cancer risk factors (1)
- Candida (1)
- Cardiovascular disease (1)
- Catherine Pozzi (1)
- Cell binding (1)
- Cell surface proteomics (1)
- ChIP-seq (1)
- Chemistry (1)
- Childhood cancer survivors (1)
- Chlamydia trachomatis (1)
- Chronic lymphoblastic leukemia (1)
- Chronic myeloid leukemia (1)
- Chronic obstrusive pulmonary disease (1)
- Chronic rhino‑sinusitis (1)
- Circadian rhythms and sleep (1)
- Clay mineralogy (1)
- CoA (1)
- Code-switching (1)
- Computer software (1)
- Coordinated Regional Climate Downscaling Experiment (CORDEX)-South Asia (1)
- Cys-loop receptor (1)
- Cystic fibrosis (1)
- DExD/H-Box RNA helicase (1)
- DFT+U (1)
- DNA repair (1)
- DNA traps (1)
- DOTATOC (1)
- Dark matter (1)
- Database searching (1)
- De-novo (1)
- Dentistry (1)
- Depression (1)
- Depression treatment (1)
- Depressive symptomatology (1)
- Diagnostic medicine (1)
- Diaphragmatic breathing (1)
- Didactics of Religion (1)
- Disease network (1)
- Dreißigjähriger Krieg (1)
- Dunce isoforms (1)
- Durchflusscytometrie (1)
- E. coli (1)
- EEG (1)
- ESBL (1)
- ESTARFM framework (1)
- EUROASPIRE survey (1)
- EW (1)
- EZH2 (1)
- Early-onset (1)
- Echnaton (1)
- Edward Saïd (1)
- Encyclopédie (1)
- EndoVAC and small bowel (1)
- Englisch (1)
- Enrichment analysis (1)
- Enterobacteriaceae (1)
- Enzyme Regulation (1)
- Enzyme kinetics (1)
- Enzyme metabolism (1)
- Enzyme regulation (1)
- Enzymes (1)
- Epicardium-derived cells (1)
- Erlebnisgesellschaft (1)
- Erotik (1)
- Europe (1)
- European Property Law (1)
- Evolution (1)
- Exercise intervention (1)
- Exotics (1)
- Experimental study (1)
- Exposure therapy (1)
- F-actin (1)
- FTY720 (1)
- Fernerkundung (1)
- Ficaria ambigua (1)
- Ficaria calthifolia (1)
- Ficaria verna (1)
- First G-APD Cherenkov Telescope (1)
- Fks1 (1)
- Flavour changing neutral currents (1)
- Fokker–Planck equation (1)
- Forecasting (1)
- Freud (1)
- Fruits (1)
- Functional magnetic resonance imaging (1)
- G protein-coupled receptors (1)
- GABA\(_{A}\) (1)
- GABBR1 (1)
- GA\(^2\)LEN (1)
- GM-CSF (1)
- GPS (1)
- GPS tracking (1)
- Gamma-ray bursts (1)
- Ganglia (1)
- Gauge-gravity correspondence (1)
- Gemeinderat (1)
- Gene expression (1)
- Gene regulation (1)
- Genetic causes of cancer (1)
- Genetics (1)
- Genom (1)
- Georgre Orwell (1)
- German translation (1)
- Gewalt (1)
- Gletscher (1)
- GmbH (1)
- Good Practices (1)
- Grimmelshausen (1)
- H441 (1)
- HECT Ligase (1)
- HLA-E matching (1)
- HNSCC (1)
- HPA axis (1)
- HSTC outcome (1)
- HUWE1 (1)
- Hadron Hadron scattering (experiments) (1)
- HeLa cells (1)
- Healthcare research (1)
- Heart failure (1)
- Heat Wave Magnitude Index (HWMI) (1)
- Hematopoietic stem cell transplantation (1)
- Herpes (1)
- High-energy jets (1)
- Hittitology (1)
- Hoffa (1)
- Holography and condensed matter physics (AdS/CMT) (1)
- Holtei, Karl von / Ein Trauerspiel in Berlin (1)
- Host cells (1)
- Human atrial stromal cells (1)
- Hypertonic (1)
- Hyrtios (1)
- Hör-Seh-Verstehen (1)
- ICD-coding of CKD (1)
- ICP4 (1)
- IFN-γ (1)
- IL-10 (1)
- IL1RA (1)
- IMR-90 (1)
- Imaging Air Cherenkov Telescope (1)
- Imaging pitfalls (1)
- Immune receptor signaling (1)
- IncRNA (1)
- Inflammatory bowel disease (1)
- Interview (1)
- Irritable bowel syndrome (1)
- Ištar ritual (1)
- Jaucourt (1)
- Jet physics (1)
- Josephson junctions (1)
- José Cardoso Pires, Lisbon (1)
- KFZA (1)
- Karriere (1)
- Karyotyp (1)
- Kenya (1)
- Killer cell immunoglobulin-like receptors (1)
- Kinderbuchwelt (1)
- Klausur (1)
- Kohl (1)
- Kommunalrecht (1)
- Komplementsatz (1)
- Korpus (1)
- LC-ESI/MS/MS (1)
- LFA-1 (1)
- LOGIC study (1)
- Landsat (1)
- Langerhans cells (1)
- Larvae (1)
- Late-effects (1)
- Latrophilin (1)
- Learning about digital Media (1)
- Learning with digital Media (1)
- Lehrwerkanalyse (1)
- Lernen mit digitalen Medien (1)
- Lernen über digitale Medien (1)
- Lernvideo (1)
- Lewis acids (1)
- Lewy-like pathology (1)
- Lumières (1)
- Lysis (medicine) (1)
- MASK (1)
- MDSC (1)
- MEMS IMU (1)
- MITE (1)
- MODIS (1)
- MPFL (1)
- MPO (1)
- MR angiography (1)
- MS (1)
- MYC (1)
- Machine learning (1)
- Manganese (1)
- Marfan syndrome (1)
- Marrakech (1)
- Mattheson (1)
- Mcl-1 (1)
- Measurement (1)
- Media Education (1)
- Medical implants (1)
- Medical journals (1)
- Medienbildung (1)
- Megalobrama amblycephala (1)
- Megaponera analis (1)
- Mehrsprachigkeit (1)
- Meliponini (1)
- Menschenrechte (1)
- Metabolic pathways (1)
- Meta‑analysis (1)
- Molecular Biophysics (1)
- Molecular biology (1)
- Montpellier (1)
- Mouse models (1)
- Multimorbidity (1)
- Multiple Myeloma (1)
- Multivariate analysis (1)
- Musical instrument (1)
- N-terminal domain (1)
- NAD (1)
- NADPH oxidase 2 (NOX2) (1)
- NF-\(\kappa\)B pathway (1)
- NFATc1 (1)
- NFKB (1)
- NK-cells (1)
- NLO QCD (1)
- NP-hard (1)
- NPC1 gene (1)
- NPC2 gene (1)
- NSG (1)
- NSG-UC (1)
- Nash equilibrium (1)
- Ndrg1 (1)
- Neisseria (1)
- Neolithic agriculture (1)
- Nestroy, Johann / Die verhängnisvolle Faschingsnacht (1)
- Neuromuscular junctions (1)
- Neutrino data (1)
- Neutrino emission (1)
- Neutrino telescope (1)
- Niemann–Pick disease type C (1)
- Ninigizibara (1)
- Non-coding RNAs (1)
- Nucleus (1)
- OCD (1)
- OLED (1)
- Observational study (1)
- Oncolytic vaccinia virus (1)
- Osmunda regalis (1)
- Osseointegration (1)
- Osteology (1)
- P. aeruginosa (1)
- P14ARF (1)
- PAR-CLIP (1)
- PD-L1 (1)
- PDE4d (1)
- PDH (1)
- PER (1)
- PRRT (1)
- PSMA (1)
- Paleopedology (1)
- Paris (1)
- Parkinson disease (1)
- Peau d’Âme (1)
- Physical activity (1)
- Physical fitness (1)
- Pitfall (1)
- Pleckstrin homology containing family member 5 (Plekhg5) (1)
- PolSAR (1)
- Portugiesisch (1)
- Predictive toxicology (1)
- Prevalence (1)
- Primary care (1)
- Prostata (1)
- Prostate Cancer (1)
- Protons (1)
- Pulmonary function (1)
- Pycnogenol (1)
- Quantum chronodynamics (1)
- R-sneutrino (1)
- RADARSAT Constellation Mission (1)
- RADARSAT-2 (1)
- RECOLA (1)
- RIG-I (1)
- RMnO3 (1)
- RNA (1)
- RNA binding protein (1)
- RNA chaperone Hfq (1)
- RNA export (1)
- RNA in situ hybridization (1)
- RNA interference (1)
- RNA sequencing (1)
- RNA-binding proteins (1)
- ROS (1)
- Radarsat-2 (1)
- Radiotracer (1)
- Raman spectroscopy (1)
- Rameau (1)
- Random Forests (1)
- Randomized controlled trial (1)
- RapidEye (1)
- Raumwahrnehmung (1)
- Real-time Kinematics (RTK) (1)
- RecQ4 (1)
- Recognition of depression (1)
- RelB (1)
- Religionsdidaktik (1)
- Remote sensing (1)
- Rhinitis (1)
- Ribosome profiling (1)
- Rubus (1)
- Rubus viridilucidus (1)
- SAH (1)
- SAMR-Model (1)
- SAMR-Modell (1)
- SHERPA (1)
- SNI (1)
- SPA-LEED (1)
- SSTR (1)
- STAT1 (1)
- STM (1)
- Saccharomyces cerevisiae (1)
- Salmonella (1)
- Search window (1)
- Secularity (1)
- Septins (1)
- Shigella (1)
- Shigellosis (1)
- Shooting an Elephant (1)
- SmB\(_{6}\) (1)
- Sodium-myoinositol cotransporter-1 (SMIT1) (1)
- South-western Burkina Faso (1)
- Spanisch (1)
- Standardized Precipitation Evapotranspiration Index (SPEI) (1)
- Stem cell transplantation (1)
- Stiffness (1)
- Streptomyces (1)
- Structural Biology (1)
- Struktur (1)
- Sunfrail (1)
- Support vector machines (1)
- Synapses (1)
- Synaptic vesicles (1)
- Syntax (1)
- Systematic review (1)
- Systematic reviews (1)
- Systole (1)
- Säkularität (1)
- T cell migration (1)
- T-cadherin (1)
- T-cells (1)
- TCF1 (1)
- TCF12 (1)
- TGFβ1 (1)
- TIMESAT (1)
- TLO (1)
- TNFR2 (1)
- TP53 (1)
- TerraSAR-X (1)
- Time measurement (1)
- Toxicity (1)
- Toxoplasma gondii (1)
- Tracer (1)
- Transcription (1)
- Transcription profiling (1)
- Transcriptional control (1)
- Transcriptome analysis (1)
- Translation efficiency (1)
- Treatment guidelines (1)
- Trees (1)
- Trieb (1)
- Tropheryma whipplei (1)
- Trypanosoma brucei (1)
- Tuberculosis (1)
- Tyrian purple (1)
- UAV (1)
- Ubiquitin (1)
- Ulcerative colitis (1)
- Ultimatum Game (1)
- Unterfranken (1)
- Unternehmensgruppe (1)
- Ureaplasma (1)
- V. saphena magna (1)
- Vegetables (1)
- Vesicles (1)
- Virology (1)
- Virtual reality (1)
- Virus (1)
- Vorkommen (1)
- WASp (1)
- WebGL (1)
- Weltanschauung (1)
- West Africa (1)
- Whipple's disease (1)
- Wilms tumour (1)
- Wiskott-Aldrich syndrome (1)
- Wissenschaftlicher Nachwuchs (1)
- X-Ray Chrystallography (1)
- Yo‐Yo intermittent recovery (1)
- Zebrafish (1)
- ZnO (1)
- [\(^{68}\)Ga] pentixafor (1)
- [\(^{68}\)Ga]Pentixafor (1)
- \(^{11}\)C-methionine (1)
- absorption (1)
- academic achievement (1)
- accelerometer (1)
- accuracy (1)
- action observation (1)
- acute (1)
- acute graft-versus-host disease (1)
- acute leukemia (AL) (1)
- acute myeloid leukaemia (1)
- acute slices (1)
- adaptation (1)
- adenocarcinoma of the lung (1)
- adenylyl cyclase signaling cascade (1)
- adhesion (1)
- adhesion GPCR (1)
- adhesion molecules (1)
- adipocytes (1)
- adrenal crisis (1)
- adrenal insufficiency (1)
- adrenal tumor (1)
- adrenocortical cancer (1)
- adsoption (1)
- adult-onset (1)
- aerobic fitness (1)
- aerobic glycolysis (1)
- agility (1)
- aging (1)
- agomelatine (1)
- agriculture (1)
- agroecology (1)
- airway remodeling (1)
- alcohol tolerance (1)
- altruism (1)
- alu elements (1)
- amenity migration (1)
- amyotrophic lateral sclerosis (1)
- anaphylaxis (1)
- anaplasia (1)
- angle-resolved photoemission spectroscopy (1)
- anidulafungin (1)
- animal autobiography (1)
- animals (1)
- anorganic chemistry (1)
- anti-cancer-agent (1)
- antibiotics (1)
- anticipatory anxiety (1)
- antidepressant (1)
- antimicrobial resistance (1)
- antimicrobials (1)
- aorta (1)
- aortic valve replacement (1)
- aortic valve stenosis (AS) (1)
- apolipoprotein-E4 (1)
- arctic (1)
- arthritis (1)
- aryltricyanoborates (1)
- assistive technology (1)
- atherosclerosis (1)
- atomic and molecular spectroscopy, (1)
- atomic force microscopy (1)
- attitude determination (1)
- auditory (1)
- auditory system (1)
- augmented reality (1)
- autism-like behavior (1)
- autoinflammation (1)
- auxins (1)
- avoidance (1)
- awareness (1)
- bacterial secretion (1)
- balaĝ-deity (1)
- band structure methods (1)
- bariatric surgery (1)
- bee (1)
- bees (1)
- behavior (1)
- behavioural ecology (1)
- beta oscillation (1)
- bi-temporal (1)
- bioactive (1)
- bioactive compound (1)
- biofeedback (1)
- biofilms (1)
- biogenic amines (1)
- biohybrid systems (1)
- bioinformatics (1)
- bioink (1)
- biological development (1)
- biological rapid deployment aortic valve (1)
- biomaterial tests (1)
- biomaterials (1)
- biomedical materials (1)
- bioprinting (1)
- blood platelets (1)
- blood-brain barrier (1)
- blood-brain barrier (BBB) model (1)
- body composition (1)
- bone (1)
- bone ligament graft (1)
- bone marrow (1)
- bone marrow stromal cells (1)
- borderline personality disorder (1)
- boron (1)
- boron-bound hydrogen (1)
- boron-centred nucleophile (1)
- borylation (1)
- brain computer interface (1)
- brain development (1)
- brain edema (1)
- brain-computer interface (1)
- branch point (1)
- bronchopulmonary dysplasia (1)
- buildup phase (1)
- cadherin-13 (CDH13) (1)
- caffeine (1)
- calcification (1)
- calcium (1)
- calcium channel antagonists (1)
- calcium fluoride nanoparticles (1)
- caloric-restriction (1)
- cancer (1)
- cancer detection and diagnosis (1)
- carbene donor (1)
- carbon dot (1)
- cardiac amyloidosis (1)
- cardiac dysfunction (1)
- cardiac rehabilitation (1)
- cardiogenic (1)
- cardiogenic shock (1)
- cardiomyocytes (1)
- cardiomyopathies (1)
- cartilage (1)
- cartilage repair (1)
- cartographic requirements (1)
- cash crops (1)
- caspase-3 (1)
- caspofungin (1)
- catabolism (1)
- cavity device (1)
- cell binding (1)
- cell cultures (1)
- cell cycle (1)
- cell fusion (1)
- cell metabolism (1)
- cell phone conversation (1)
- cell proliferation (1)
- cell signalling (1)
- cell-autonomous defense (1)
- cells (1)
- cellular stress (1)
- central clocks (1)
- central complex (1)
- ceramide analogs (1)
- cerebral small vessel disease (1)
- change detection (1)
- change of direction (1)
- change‐of‐direction movement (1)
- characterization (1)
- charged hadron response (1)
- checkpoint inhibition (1)
- chemokine receptor (1)
- children (1)
- cholera (1)
- cholinergic activity (1)
- chondrogenesis (1)
- chorioamnionitis (1)
- chromophore (1)
- chronic heart failure (1)
- chronic nonbacterial osteomyelitis (1)
- chronic pain (1)
- chronic recurrent multifocal osteomyelitis (1)
- chronobiology (1)
- circadian clock (1)
- circadian mechanisms (1)
- circadian rhythm (1)
- climate change (1)
- clinical applications (1)
- clinical genetics (1)
- clinical study (1)
- cloning (1)
- co-stimulation, (1)
- coaching (1)
- cognition (1)
- cognitive conflict (1)
- cognitive control (1)
- cognitive decline (1)
- cognitive impairment (1)
- cognitive processes (1)
- collagens (1)
- colorectal cancer (CRC) (1)
- colorectal carcinoma (1)
- colour (1)
- comparison (1)
- complex disorders (1)
- compound conditioning (1)
- comprehensive management (1)
- conflict adaptation (1)
- conflict experience (1)
- conflict strength (1)
- confocal laser scanning microscopy (1)
- confocal-microscopy based automated quantification (1)
- conocer (1)
- consistency (1)
- consumption priming (1)
- contact lens (1)
- contextual anxiety (1)
- contextualist narratology (1)
- contrastive analysis of languages (1)
- cord blood (1)
- coronary artery disease (1)
- correlates (1)
- costimulation (1)
- cotton (1)
- coverage (1)
- critical size defect (1)
- cropping systems (1)
- cross-modal action (1)
- cross-priming (1)
- cross-sectional (1)
- crotonase (1)
- cryptic (1)
- cultural and literary animal studies (1)
- cuneiform (1)
- curative resection (1)
- cyclic dipeptide (1)
- cyclic nucleotides such as cyclic adenosine monophosphate (1)
- cysteine (1)
- cytokine secretion (1)
- cytokines (1)
- cytokinesis (1)
- cytosol (1)
- cytotoxic (1)
- cytotoxic effect (1)
- cytotoxicity (1)
- dCIRL (1)
- dRNA-seq (1)
- damped circadian clock (1)
- data fusion (1)
- decadal predictability (1)
- decay channels (1)
- decision-making (1)
- decomposition (1)
- deep brain stimulation (1)
- defensive system reactivity (1)
- deficiency (1)
- deformed wing virus (1)
- dehydrogenase (1)
- deletion mutagenesis (1)
- delocalization (1)
- dementia (1)
- demographic change (1)
- dendritic spines (1)
- density functional theory (1)
- derivatives (1)
- desert ants (1)
- desk-based (1)
- detector (1)
- deubiquitinase (1)
- diagnosis (1)
- dicalcium phosphate cement (1)
- dictatorship (1)
- diet (1)
- differential games (1)
- differential olfactory conditioning (1)
- differentiation (1)
- diffusion-weighted MRI (1)
- digitales Unterrichtsmaterial (1)
- digitalized teaching material (1)
- dimers (1)
- dislocation (1)
- distinction (1)
- diurnal profile (1)
- division of labor (1)
- dobutamine stress echocardiography (1)
- domain knowledge (1)
- dorsal raphe (1)
- dual polarimetry (1)
- dual tasks (1)
- dual-response costs (1)
- dunce (1)
- duodenal perforation (1)
- duodenal trauma (1)
- dynamical downscaling (1)
- dynamical mean field (1)
- eEF1A1 (1)
- echinocandin (1)
- echinocandins (1)
- eclosion (1)
- ecosystem services (1)
- effective field theories (1)
- effort (1)
- ejection fraction (1)
- electromagnon (1)
- electronic coupling (1)
- electronic structure (1)
- electrostatics (1)
- elliptic problems (1)
- embryology (1)
- encephalitis (1)
- end-user evaluation (1)
- endocrinology (1)
- endophthalmitis (1)
- endothelial cells (1)
- endurance (1)
- enzymes (1)
- epidermal growth factor (1)
- epigenetics in the nervous system (1)
- epigenomics (1)
- epithelial cells (1)
- equine autozoography (1)
- eukaryota (1)
- euroaspire (1)
- europium (1)
- event-related potential (ERP) (1)
- evolutionary response (1)
- ex vivo model (1)
- exciton dynamics (1)
- excitons (1)
- experimental archaeology (1)
- experimental autoimmune encephalomyelitis (1)
- experimental models of disease (1)
- experimental physics (1)
- extinction (1)
- extra corporeal membrane oxygenator (1)
- extracellular vesicles (EVs) (1)
- extracorporeal membrane oxygenation (1)
- eye movements (1)
- eye tracking (1)
- fMRI (1)
- face (1)
- facet joint degeneration (1)
- facet joint injection (1)
- factor H (1)
- factor XII (1)
- fat appetite (1)
- fatty degeneration (1)
- fear conditioning (1)
- fear of progression (1)
- feasibility (1)
- female (1)
- femur (1)
- ferromagnetism (1)
- fetal cord blood (1)
- fetal programming (1)
- fibrinogen (1)
- fibroblast chemotaxis (1)
- fibroblasts (1)
- fictional autobiography (1)
- fingolimod (1)
- finite differences (1)
- floral resource distribution (1)
- flotillin (1)
- flow cytometry (1)
- fluorescence resonance energy transfer (1)
- foamy virus (1)
- foamy viruses (1)
- focal brain lesion (1)
- follow-up (1)
- forager (1)
- foraging behaviour (1)
- foreign body reaction (1)
- fracture (1)
- fredholm operator (1)
- frequency combs (1)
- functional clustering (1)
- functional complementarity (1)
- functional magnetic resonance imaging (1)
- functional redundancy (1)
- functional training (1)
- fungal genetics (1)
- fungal physiology (1)
- fungal structure (1)
- gambiense (1)
- gapless Andreev bound states (1)
- gastrointestinal tract (1)
- gauge-gravity correspondence (1)
- gaze (1)
- gaze patterns (1)
- gender differences (1)
- general transcription factor IIH (TFIIH) (1)
- generation effect (1)
- generative systems (1)
- genetic heterogeneity (1)
- genetic testing (1)
- genetically modified animals (1)
- genetically modified plants (1)
- genome collection (1)
- genome integrity (1)
- genome sequencing (1)
- genome-wide association study (GWAS) (1)
- genomic damage (1)
- genomic imprinting (1)
- genomic libraries (1)
- genomic sequence (1)
- genomics research (1)
- genotyping (1)
- gestational diabetes mellitus (1)
- glaucoma (1)
- glioblastoma multiforme (1)
- glucan synthase (1)
- glucocorticoids (1)
- glucose metabolism (1)
- glutaminase inhibition (1)
- glycine receptor beta subunit (1)
- glycoprotein Ib (1)
- glycoprotein receptor Ib (1)
- growing season length (GSL) (1)
- growth cone (1)
- guideline implementation (1)
- gut microflora (1)
- habitat information (1)
- hadronic calorimeter (1)
- hadronic physics (1)
- half-metals (1)
- hangover (1)
- head and neck cancer (1)
- head and neck carcinoma (1)
- health monitoring (1)
- heart failure (1)
- heart valve prosthesis (1)
- heat currents (1)
- heavy fermion insulators (1)
- height-adjustable desk (1)
- helimagnets (1)
- hematopoietic stem cell transplantation (HSCT) (1)
- hematopoietic stem cells (1)
- hemodynamics (1)
- hepatic resection (1)
- herbivorous diet (1)
- herpes virus (1)
- heterotopia (1)
- hexakisadducts (1)
- high energy neutrinos (1)
- high-throughput screening (1)
- high-volume training (1)
- hippocampal formation (1)
- hippocampal volume (1)
- hippocampus (1)
- histones (1)
- honey bees (1)
- honeybees (1)
- hormone receptors (1)
- horse-science (1)
- hos tcells (1)
- hospital (1)
- human (1)
- human genetics (1)
- human induced pluripotent stem cells (hiPSCs)human induced pluripotent stem cells (hiPSCs) (1)
- human leukocyte antigen-E (HLA-E) (1)
- human rights (1)
- humanized tumor (1)
- hydration dynamics (1)
- hydrocortisone (1)
- hydrogen bonding (1)
- hymenoptera (1)
- hypercholesterolemia (1)
- hyperglycemia (1)
- hypoplasia of fatty tissue (1)
- identification (1)
- identified particle response (1)
- image analysis (1)
- imaging (1)
- imaging the immune system (1)
- immune cells (1)
- immune regulation (1)
- immune response (1)
- immune system (1)
- immunity (1)
- immunoblotting (1)
- immunoglobin-A (1)
- immunohistochemistry (1)
- immunology and microbiology section (1)
- impella 5.0 (1)
- implant (1)
- implantable neurostimulators (1)
- implants (1)
- indigo (1)
- inducible deletion (1)
- inelastic neutron scattering (1)
- infectious diseases (1)
- infectious-disease diagnostics (1)
- infrared radiation (1)
- infrared spectroscopy (1)
- infrared-spectra (1)
- ingestible sensor (1)
- inguinal lymph node dissection (1)
- innate immune response (1)
- innate immunity (1)
- insect (1)
- insula (1)
- insulin (1)
- insulin treatment (1)
- integer linear programming (1)
- intelligence (1)
- intercellular adhesion (1)
- interleukin 1 receptor antagonist (1)
- intermediate phenotype approach (1)
- intermuscular bone (1)
- interval training (1)
- intrauterine growth (1)
- intravenous ceftriaxone (1)
- intravitreal vancomycin and amikacin (1)
- invasion (1)
- inverse seesaw (1)
- ion channels in the nervous system (1)
- iron (1)
- irrigation (1)
- isoproterenol (1)
- just noticeable difference (JND) (1)
- juvenile idiopathic arthritis (1)
- kinases (1)
- kinesin (1)
- la campagne d’Égypte (1)
- laboratory techniques and procedures (1)
- lactase persistence (1)
- lactoferricin B (1)
- lactose (1)
- land surface phenology (1)
- landscape ecology (1)
- laser physics (1)
- laser spectroscopy (1)
- latent change (1)
- lead structure (1)
- learning outcome (1)
- learning with expository texts (1)
- leaves (1)
- les Turqueries (1)
- leukemia (1)
- levodopa-induced dyskinesia (1)
- life writing (1)
- light pulses (1)
- linalool (1)
- linalyl acetate (1)
- lipids (1)
- listeriolysin O (1)
- liver metastasis (1)
- liver resection (1)
- livin (1)
- long-term monitoring (1)
- long-term patency (1)
- look-back behavior (1)
- lovastatin (1)
- low-gradient AS (1)
- lower body (1)
- lumbar degenerative disease (1)
- lumbar spinal stenosis (1)
- lung resection (1)
- lymph nodes (1)
- lymphocyte activation (1)
- lyre (1)
- mTOR-inhibitor RAD-001 (1)
- magnetic properties and materials (1)
- magnetic resonance imaging (1)
- magnetic resonance imaging (MRI) (1)
- magnetometer (1)
- malignant melanoma (1)
- map labeling (1)
- marine natural products (1)
- maritime pine bark extract (1)
- markers (1)
- mass spectrometry (1)
- materials for optics (1)
- mating success (1)
- mature cell-cell contacts (1)
- mayo stem (1)
- measles (1)
- measurement invariance (1)
- mechanobiology (1)
- medical dialysis (1)
- melatonin (1)
- membrane receptor signaling (1)
- memory bias (1)
- meningitis (1)
- mental health (1)
- meristems (1)
- mesenchymal stem cell (1)
- meta-autobiography (1)
- metabotropic signalling (1)
- metaproteomics (1)
- metatranscriptomics (1)
- miR-21 (1)
- miRNA (1)
- miRNAs (1)
- micafungin (1)
- microRNA–target interaction (1)
- microalga-bacteria interaction (1)
- microbiome (1)
- microenvironment (1)
- microglia (1)
- microresonators (1)
- microsoft band 2 (1)
- microswimmer (1)
- microwave (1)
- migration (1)
- mineralocorticoid antagonist (1)
- minimal invasive surgery (1)
- minimal supersymmetric standard model (MSSM) (1)
- minimally invasive surgery (1)
- mitochondria (1)
- modelling (1)
- modulation spectroscopy (1)
- molecular imaging (1)
- molecular modelling (1)
- molecular neuroscience (1)
- molting (1)
- monitoring (1)
- monsoon rainfall (1)
- mood states (1)
- morphometry (1)
- motoneuron disease (1)
- motor axon (1)
- motor cortex (1)
- motor simulation (1)
- mouse brain microvascular endothelial cell cultur (1)
- multi-leaf collimator (1)
- multi-sensor (1)
- multiferroics (1)
- multifunctional nanoparticles (1)
- multigrid schemes (1)
- multimedia learning (1)
- multimodal imaging (1)
- multiple sclerosis (1)
- multiple-level replantation (1)
- multipotent fetal neural stem cells (fNSCs) (1)
- murine model (1)
- muscle oxygen saturation (1)
- mushroom body (1)
- musical syntax (1)
- myeloid (1)
- nanocavities (1)
- nanoparticles (1)
- nanoscience and technology (1)
- naphthylisoquinoline alkaloid (1)
- narration (1)
- national parks (1)
- natural approach (1)
- natural history (1)
- natural killer cells (1)
- near-gap spectra (1)
- necrotic cell death (1)
- neisseria meningitidis (1)
- neonatal morbidity (1)
- nephroblastoma (1)
- nesting habit (1)
- networks (1)
- neural fear network activation (1)
- neuroanatomy (1)
- neurodegeneration (1)
- neurodevelopment (1)
- neuroendocrine tumor (1)
- neurological disorders (1)
- neuronal development (1)
- neuropathic pain (1)
- neuropeptide pathway (1)
- neurophysiology (1)
- neuropsychiatric disorders (1)
- neurotrophic factors (1)
- neurovascular unit in vitro (1)
- neutral sphingomyelinase (1)
- neutrino (1)
- neutrino emission (1)
- neutrino flux (1)
- neutrino telescope (1)
- next-to-leading-order electroweak corrections (1)
- nickel (1)
- none (1)
- novelty processing (1)
- nucleophilic addition (1)
- nucleophilic substitution (1)
- numerical analysis (1)
- nurse bee (1)
- nutrition (1)
- nutritional ecology (1)
- observation inflation (1)
- occlusion (1)
- occupational sitting and physical activity questionnaire (1)
- octopamine (1)
- ocular infection (1)
- oculomotor control (1)
- office-workers (1)
- older poor readers (1)
- oligopeptides (1)
- oncostatin M (1)
- online-Kommunikation (1)
- opioid peptides (1)
- opioid receptors (1)
- optical spectroscopy (1)
- optics and photonics (1)
- optimal control (1)
- optogenetics (1)
- oral anticancer drugs (1)
- oral cefpodoxime (1)
- oral doxycycline (1)
- orientalisme (1)
- orientation (1)
- oscillator strengths (1)
- osteochondral biopsy (1)
- osteocytes (1)
- osteopontin (1)
- outdoor recreation (1)
- ovarian cancer (1)
- oxaliplatin (1)
- oxidation (1)
- oxidative stress (1)
- oxygen tension (1)
- oxygenation (1)
- oxytocin (1)
- p34 (1)
- p44 (1)
- pH-regulated antigen 1 (Pra1) (1)
- paediatric research (1)
- pain (1)
- pain behavior (1)
- pancreatic cancer (1)
- paradoxical effect (1)
- paradoxical growth (1)
- parasitic cell cycles (1)
- parasitic diseases (1)
- parasomn (1)
- particle physics (1)
- patch-clamp (1)
- patella (1)
- pathogenic bacteria (1)
- pathogens (1)
- patient education (1)
- patients’ awareness (1)
- pattern recognition receptors (1)
- patterning (1)
- pedestrian motion (1)
- pellet culture (1)
- peptide receptor radionuclide therapy (1)
- peptide sensors (1)
- perception (1)
- performance monitoring (1)
- peri-implant disease (1)
- periodization (1)
- perioperative changes (1)
- peripheral clocks (1)
- permease (1)
- pharmacotherapy (1)
- phase contrast (1)
- phasic threat responding (1)
- phenomenological models (1)
- philosophie du langage (1)
- phosphorylation (1)
- photoluminescence (1)
- photoluminescence excitation (1)
- photonic devices (1)
- phycosphere biofilm (1)
- physicians’ awareness (1)
- physiological (1)
- phytic acid (1)
- pine bark extract (1)
- planning study (1)
- plant extract (1)
- plant growth and development (1)
- plant-insect interactions (1)
- plantation (1)
- plant–insect interactions (1)
- plasma oxysterols (1)
- plasmons (1)
- plasticity (1)
- platelets (1)
- pleural mesothelioma (1)
- poetics of knowledge (1)
- point mutation (1)
- point-feature label placement (1)
- point-of-care echocardiography (1)
- polaritons (1)
- polarization (1)
- pollen (1)
- pollination (1)
- pollinator decline (1)
- polycyclic aromatic hydrocarbons (1)
- polyglandular autoimmune syndrome (1)
- polymerase chain reaction (1)
- polymers (1)
- polyol (1)
- polyphenols (1)
- population (1)
- population structure (1)
- population-based study (1)
- porous materials (1)
- positron emission tomography imaging (1)
- postcolonial novel (1)
- postoperativ (1)
- posttranscriptional gene regulation (1)
- power training (1)
- practical electrodes (1)
- prediction (1)
- prefrontal cortex (1)
- pregnancy anxiety (1)
- prenatal stress (1)
- preserved ejection fraction (1)
- prevalence (1)
- primary care (1)
- primary prevention (1)
- primary school (1)
- proGenomes (1)
- proboscis extension reflex (1)
- prognosis (1)
- prokaryotic clade (1)
- prokaryotic subspecies (1)
- proliferation (1)
- prosocial behavior (1)
- prosocial tendency measure (1)
- protein design (1)
- protein hydration (1)
- protein structure (1)
- protein–protein interaction (1)
- proteomes (1)
- pseudo-severe AS (1)
- psychiatric disorders (1)
- psychophysics (1)
- psychosocial workplace risk assessment (1)
- pulley rupture (1)
- pulse wave velocity (1)
- purine-rich element (1)
- pyrene dimer (1)
- qPCR (1)
- quad polarimetry (1)
- quality indicators (1)
- quality of health care (1)
- quality of life (1)
- quanititative characterization (1)
- quantitativ (1)
- quantum dot (1)
- quantum dots (1)
- quantum information (1)
- quantum mechanical coupling (1)
- quantum well (1)
- quartic gauge couplings (QGCs) (1)
- radial glia (1)
- radii (1)
- radionuclide therapy (1)
- radiotherapy (1)
- random forest (1)
- randomized controlled study (1)
- re-irradiation (1)
- re-planning (1)
- reach-to-grasp movement (1)
- reactivating p53 and inducing tumor apoptosis (RITA) (1)
- reading comprehension (1)
- receptor (1)
- receptor pharmacology (1)
- reconstruction (1)
- recovery (1)
- recruitment (1)
- reflexive component (1)
- regeneration (1)
- regional development (1)
- regional recurrence (1)
- regulatory T cell (1)
- regulatory circuit downstream (1)
- relA (1)
- remyelination (1)
- renal dysfunction (1)
- repeated sprint ability (1)
- replacement (1)
- replication (1)
- reproductive asynchrony (1)
- rescue behavior (1)
- resin (1)
- resistance mechanism (1)
- resolvin (1)
- resveratrol (1)
- retinal development (1)
- retrospective study (1)
- rheology (1)
- rhythm perception (1)
- ribosome profiling (1)
- risk factor (1)
- risk factor control (1)
- robotic table motion (1)
- root growth (1)
- rotator cuff (1)
- sacbrood virus (1)
- samarium hexaboride (1)
- scaffold protein (1)
- scanning electron microscopy (1)
- screening for distress (1)
- season (1)
- secondary brain damage (1)
- sedentary behavior (1)
- self-management (1)
- semiconductor quantum dot (1)
- sensor assessment (1)
- sensory chewing gums (1)
- sensory physiology (1)
- sept3 (1)
- sept5a (1)
- sept5b (1)
- septic (1)
- septin (1)
- sequence alignment (1)
- sequence assembly tools (1)
- serum (1)
- sesame (1)
- sex-specific mortality (1)
- sexual dimorphism in timing (1)
- shape (1)
- shock (1)
- shorelines (1)
- short hip stem (1)
- short-term memory (1)
- shoulder surgery (1)
- signal transduction (1)
- silicon photo multiplier (1)
- single nucleotide polymorphisms (1)
- single-electron transistor (1)
- single-electron tunneling (1)
- sitting time (1)
- skin conductance response (SCR) (1)
- sky-compass pathway (1)
- slash-and-burn (1)
- sleep-related eating (1)
- sleeping sickness (1)
- social immunity (1)
- sodium/glucose cotransporters (SGLT) (1)
- solitons (1)
- spatial behaviour (1)
- special language of music (1)
- specimen storage (1)
- spectroscopic analysis (1)
- speed (1)
- sperm (1)
- spider (1)
- spidroin (1)
- spin waves (1)
- spin-phonon coupling (1)
- spintronics (1)
- splice regulation (1)
- sponges (1)
- sports (1)
- standard seesaw (1)
- staphilococci (1)
- stem cells (1)
- stereochemistry (1)
- stereotactic irradiation (1)
- stereotypes (1)
- streptomyces (1)
- stress (1)
- stringent response (1)
- stroke register (1)
- stroke unit (1)
- stroke unit care (1)
- strong coupling (1)
- structural biology (1)
- structure-activity (1)
- subcutaneous human tumors (1)
- substrate channeling (1)
- subthalamic nucleus (1)
- sucrose (1)
- sulfates (1)
- sulfides (1)
- sulfites (1)
- sulfur (1)
- super-resolution microscopy (1)
- supersymmetric model (1)
- supersymmetry (SUSY) (1)
- surface collisions (1)
- surface conditioning (1)
- surface stress (1)
- surfactants (1)
- surgery (1)
- surgical oncology (1)
- surgical resection (1)
- surgical site infection (1)
- surveillance (1)
- survival (1)
- survival analysis (1)
- sustained attention (1)
- sustained threat responding (1)
- swimming (1)
- syllable-based intervention (1)
- synaptic transmission (1)
- synaptic vesicles (1)
- synovial fluid (1)
- synovitis (1)
- synthesis (1)
- synthetic peptides (1)
- systems biology (1)
- systolic dysfunction (1)
- task rules (1)
- taxonomic description (1)
- technique of fragmentary (1)
- technology (1)
- temperate Europe (1)
- tetracyclines (1)
- tetraparesis (1)
- therapeutic strategy (1)
- thermal devices (1)
- thermodynamics (1)
- thiosulfates (1)
- throat (1)
- thrombo-inflammation (1)
- thrombopoiesis (1)
- time perception (1)
- time-resolved photoluminescence (1)
- tinnitus (1)
- tissue regeneration (1)
- tissue remodeling (1)
- tongue (1)
- topic ofloxacin (1)
- topological insulators (1)
- topological magnetoelectric effect (1)
- topological materials (1)
- topological matter (1)
- total hip arthroplasty (1)
- toxicity (1)
- toxicology (1)
- toxins (1)
- training intensity distribution (1)
- training optimization (1)
- trans-Golgi network (1)
- trans-formanilide (1)
- transcriptional control (1)
- transient middle cerebral artery (1)
- transient middle cerebral artery occlusion (1)
- transient receptor potential channels (1)
- translational regulation (1)
- transstomal endoluminal vacuum therapy (1)
- treg cells (1)
- trend analysis (1)
- triboson production (1)
- triple gauge couplings (TGCs) (1)
- trkB (1)
- tsetse fly (1)
- tumor immunology (1)
- tumor vaccination (1)
- tumour heterogeneity (1)
- tundra (1)
- twin study (1)
- type VII secretion system (1)
- ultrasound (1)
- urban discourse (1)
- urban semiotics (1)
- user interfaces (1)
- vaccination (1)
- vagus nerve stimulation (1)
- valence (1)
- valleytronics (1)
- variability (1)
- varicella (1)
- variocosities (1)
- vascular surgery (1)
- vector navigation (1)
- vector-boson scattering (1)
- verbal fluency task (1)
- very high energy gamma rays (1)
- vespula (1)
- vicinal surfaces (1)
- video recording (1)
- vigilance (1)
- violence (1)
- virtual isocentre (1)
- virtual reality (1)
- virulenceregulatory evolution (1)
- virus vectors (1)
- visual (1)
- visual attention (1)
- visual orientation (1)
- visual saliency (1)
- vitamin D (1)
- vitrectomy (1)
- vocabulary of singing (1)
- wall shear stress (1)
- water microbiology (1)
- water migration (1)
- wearable (1)
- wearable sensors (1)
- weight loss (1)
- whole genome (1)
- word reading fluency (1)
- work-related stress (1)
- working memory (1)
- worldview (1)
- x-ray crystallography (1)
- zinc oxide (1)
- zinc oxide nanoparticles (1)
- zinc-finger (1)
- zoology (1)
- İnandık (1)
- α-synuclein (1)
Institute
- Theodor-Boveri-Institut für Biowissenschaften (61)
- Physikalisches Institut (31)
- Institut für Theoretische Physik und Astrophysik (21)
- Fakultät für Physik und Astronomie (20)
- Institut für Psychologie (20)
- Medizinische Klinik und Poliklinik I (17)
- Neurologische Klinik und Poliklinik (17)
- Medizinische Klinik und Poliklinik II (16)
- Institut für Molekulare Infektionsbiologie (14)
- Rudolf-Virchow-Zentrum (14)
Sonstige beteiligte Institutionen
Background:
Sleep-related eating may occur in the context of mental illness, sleep disorders, or psychopharmacological treatment. Frequently, sleep-related eating leads to severe weight gain and, so far, there are no treatment options for the condition.
Case presentation:
We report the case of a 54-year-old white woman with depression, panic disorder, and sleep apnea under treatment with various antidepressants who developed severe sleep-related eating. Her sleep-related eating completely vanished after addition of agomelatine, it reoccurred after cessation of agomelatine, and vanished again after her re-exposure to another melatonergic drug, extended melatonin.
Conclusions:
This case suggests that melatonergic drugs lead to relief from sleep-related eating, even when the condition occurs in the context of physical and mental disorders as well as psychopharmacological treatment.
Background: Faster rates of cognitive decline are likely to result in earlier onset of cognitive impairment and dementia. d-galactose, a derivative of lactose, is used in animal studies to induce neurodegeneration. Milk is the primary source of lactose in the human diet, and its effects on cognitive decline have not been fully evaluated. Objective: Assess the association of milk intake with change in cognitive function over 20 years. Methods: A total of 13,751 participants of the Atherosclerosis Risk in Communities (ARIC) cohort completed a food frequency questionnaire and three neurocognitive evaluations from 1990 through 2013. Two single nucleotide polymorphisms (SNPs) were used to determine lactase persistence (LCT-13910 C/T for Whites and LCT-14010 G/C for Blacks). Mixed-effects models were used to study the association of milk intake with cognitive change. Multiple imputations by chained equations were used to account for attrition. Results: Milk intake greater than 1 glass/day was associated with greater decline in the global z-score over a 20-year period. The difference in decline was 0.10 (95% CI: 0.16, 0.03) z-scores, or an additional 10% decline, relative to the group reporting “almost never” consuming milk. Conclusions: Replication of these results is warranted in diverse populations with greater milk intake and higher variability of lactase persistence genotype.
Despite growing effort to advance materials towards a low fibrotic progression, all implants elicit adverse tissue responses. Pre-clinical biomaterial assessment relies on animals testing, which can be complemented by in vitro tests to address the Russell and Burch’s 3R aspect of reducing animal burden. However, a poor correlation between in vitro and in vivo biomaterial assessments confirms a need for suitable in vitro biomaterial tests. The aim of the study was to identify a test setting, which is predictive and might be time- and cost-efficient. We demonstrated how sensitive in vitro biomaterial assessment based on human primary macrophages depends on test conditions. Moreover, possible clinical scenarios such as lipopolysaccharide contamination, contact to autologous blood plasma, and presence of IL-4 in an immune niche influence the outcome of a biomaterial ranking. Nevertheless, by using glass, titanium, polytetrafluorethylene, silicone, and polyethylene representing a specific material-induced fibrotic response and by comparison to literature data, we were able to identify a test condition that provides a high correlation to state-of-the-art in vivo studies. Most important, biomaterial ranking obtained under native plasma test conditions showed a high predictive accuracy compared to in vivo assessments, strengthening a biomimetic three-dimensional in vitro test platform.
Background
Arrhythmogenic cardiomyopathy is an inherited heart muscle disorder leading to ventricular arrhythmias and heart failure, mainly as a result of mutations in cardiac desmosomal genes. Desmosomes are cell-cell junctions mediating adhesion of cardiomyocytes; however, the molecular and cellular mechanisms underlying the disease remain widely unknown. Desmocollin-2 is a desmosomal cadherin serving as an anchor molecule required to reconstitute homeostatic intercellular adhesion with desmoglein-2. Cardiac specific lack of desmoglein-2 leads to severe cardiomyopathy, whereas overexpression does not. In contrast, the corresponding data for desmocollin-2 are incomplete, in particular from the view of protein overexpression. Therefore, we developed a mouse model overexpressing desmocollin-2 to determine its potential contribution to cardiomyopathy and intercellular adhesion pathology.
Methods and results
We generated transgenic mice overexpressing DSC2 in cardiac myocytes. Transgenic mice developed a severe cardiac dysfunction over 5 to 13 weeks as indicated by 2D-echocardiography measurements. Corresponding histology and immunohistochemistry demonstrated fibrosis, necrosis and calcification which were mainly localized in patches near the epi- and endocardium of both ventricles. Expressions of endogenous desmosomal proteins were markedly reduced in fibrotic areas but appear to be unchanged in non-fibrotic areas. Furthermore, gene expression data indicate an early up-regulation of inflammatory and fibrotic remodeling pathways between 2 to 3.5 weeks of age.
Conclusion
Cardiac specific overexpression of desmocollin-2 induces necrosis, acute inflammation and patchy cardiac fibrotic remodeling leading to fulminant biventricular cardiomyopathy.
Upon systemic infection with human pathogenic yeast Candida albicans (C. albicans), human monocytes and polymorph nuclear neutrophilic granulocytes are the first immune cells to respond and come into contact with C. albicans. Monocytes exert immediate candidacidal activity and inhibit germination, mediate phagocytosis, and kill fungal cells. Here, we show that human monocytes spontaneously respond to C. albicans cells via phagocytosis, decondensation of nuclear DNA, and release of this decondensed DNA in the form of extracellular traps (called monocytic extracellular traps: MoETs). Both subtypes of monocytes (CD14\(^{++}\)CD16\(^−\)/CD14\(^+\)CD16\(^+\)) formed MoETs within the first hours upon contact with C. albicans. MoETs were characterized by the presence of citrullinated histone, myeloperoxidase, lactoferrin, and elastase. MoETs were also formed in response to Staphylococcus aureus and Escherichia coli, indicating a general reaction of monocytes to infectious microbes. MoET induction differs from extracellular trap formation in macrophages as MoETs are not triggered by simvastatin, an inhibitor of cholesterol synthesis and inducer of extracellular traps in macrophages. Extracellular traps from both monocytes and neutrophils activate complement and C3b is deposited. However, factor H (FH) binds via C3b to the extracellular DNA, mediates cofactor activity, and inhibits the induction of the inflammatory cytokine interleukin-1 beta in monocytes. Altogether, the results show that human monocytes release extracellular DNA traps in response to C. albicans and that these traps finally bind FH via C3b to presumably support clearance without further inflammation.
Brain μ-opioid receptors (MORs) stimulate high-fat (HF) feeding and have been implicated in the distinct long term outcomes on body weight of bariatric surgery and dieting. Whether alterations in fat appetite specifically following these disparate weight loss interventions relate to changes in brain MOR signaling is unknown. To address this issue, diet-induced obese male rats underwent either Roux-en-Y gastric bypass (RYGB) or sham surgeries. Postoperatively, animals were placed on a two-choice diet consisting of low-fat (LF) and HF food and sham-operated rats were further split into ad libitum fed (Sham-LF/HF) and body weight-matched (Sham-BWM) to RYGB groups. An additional set of sham-operated rats always only on a LF diet (Sham-LF) served as lean controls, making four experimental groups in total. Corresponding to a stage of weight loss maintenance for RYGB rats, two-bottle fat preference tests in conjunction with small-animal positron emission tomography (PET) imaging studies with the selective MOR radioligand [\(^{11}\)C]carfentanil were performed. Brains were subsequently collected and MOR protein levels in the hypothalamus, striatum, prefrontal cortex and orbitofrontal cortex were analyzed by Western Blot. We found that only the RYGB group presented with intervention-specific changes: having markedly suppressed intake and preference for high concentration fat emulsions, a widespread reduction in [\(^{11}\)C]carfentanil binding potential (reflecting MOR availability) in various brain regions, and a downregulation of striatal and prefrontal MOR protein levels compared to the remaining groups. These findings suggest that the suppressed fat appetite caused by RYGB surgery is due to reduced brain MOR signaling, which may contribute to sustained weight loss unlike the case for dieting.
Nearly a quarter of the Alpine area is covered by a dense network of large protected areas (LPAs) of the four categories national park(NP), biosphere reserve (BR), nature park and world natural heritage site (WNHS). From the time of early industrialization, the Alpine area has undergone a mixed and increasingly polarized demographic development between the poles of immigration and emigration. This article investigates the possible mutual impact of population development and the existence of LPAs. The research design includes a quantitative survey of all Alpine LPAs in terms of their population development and the structure of immigration in the first decade of the 21st century. This will be linked with qualitative expert interviews in four selected NPs. The overall results allow an interpretation of the statistical
correlations between type of LPA and migration.
In the present report, well-defined WO3 nanorods (NRs) and a rGO–WO\(_3\) composite were successfully synthesized using a one-pot hydrothermal method. The crystal phase, structural morphology, shape, and size of the as-synthesized samples were studied using X-ray diffraction (XRD) and transmission electron microscopy (TEM) measurements. The optical properties of the synthesized samples were investigated by Raman, ultraviolet-visible (UV-Vis) and photoluminescence (PL) spectroscopy. Raman spectroscopy and TEM results validate the formation of WO\(_3\) (NRs) on the rGO sheet. The value of the dielectric constant (ε′) of WO3 NRs and rGO–WO\(_3\) composite is decreased with an increase in frequency. At low frequency (2.5 to 3.5 Hz), the value of ε′ for the rGO–WO3 composite is greater than that of pure WO\(_3\) NRs. This could be due to the fact that the induced charges follow the ac signal. However, at higher frequency (3.4 to 6.0), the value of ε′ for the rGO–WO\(_3\) composite is less compared to that of the pure WO3 NRs. The overall decrease in the value of ε′ could be due to the occurrence of a polarization process at the interface of the rGO sheet and WO3 NRs. Enhanced interfacial polarization in the rGO–WO\(_3\) composite is observed, which may be attributed to the presence of polar functional groups on the rGO sheet. These functional groups trap charge carriers at the interface, resulting in an enhancement of the interfacial polarization. The value of the dielectric modulus is also calculated to further confirm this enhancement. The values of the ac conductivity of the WO\(_3\) NRs and rGO–WO\(_3\) composite were calculated as a function of the frequency. The greater value of the ac conductivity in the rGO–WO\(_3\) composite compared to that of the WO\(_3\) NRs confirms the restoration of the sp:\(^{++}\) network during the in situ synthesis of the rGO–WO\(_3\) composite, which is well supported by the results obtained by Raman spectroscopy.
We have investigated optical properties of hybrid two-dimensional-zero-dimensional (2D-0D) tunnel structures containing strongly elongated InAs/InP(001) quantum dots (called quantum dashes), emitting at 1.55 μm. These quantum dashes (QDashes) are separated by a 2.3 nm-width barrier from an InGaAs quantum well (QW), lattice matched to InP. We have tailored quantum-mechanical coupling between the states confined in QDashes and a QW by changing the QW thickness. By combining modulation spectroscopy and photoluminescence excitation, we have determined the energies of all relevant optical transitions in the system and proven the carrier transfer from the QW to the QDashes, which is the fundamental requirement for the tunnel injection scheme. A transformation between 0D and mixed-type 2D-0D character of an electron and a hole confinement in the ground state of the hybrid system have been probed by time-resolved photoluminescence that revealed considerable changes in PL decay time with the QW width changes. The experimental discoveries have been explained by band structure calculations in the framework of the eight-band k·p model showing that they are driven by delocalization of the lowest energy hole state. The hole delocalization process from the 0D QDash confinement is unfavorable for optical devices based on such tunnel injection structures.
Bacteriophage AR9 is a recently sequenced jumbo phage that encodes two multisubunit RNA polymerases. Here we investigated the AR9 transcription strategy and the effect of AR9 infection on the transcription of its host, Bacillus subtilis. Analysis of whole-genome transcription revealed early, late, and continuously expressed AR9 genes. Alignment of sequences upstream of the 5′ ends of AR9 transcripts revealed consensus sequences that define early and late phage promoters. Continuously expressed AR9 genes have both early and late promoters in front of them. Early AR9 transcription is independent of protein synthesis and must be determined by virion RNA polymerase injected together with viral DNA. During infection, the overall amount of host mRNAs is significantly decreased. Analysis of relative amounts of host transcripts revealed notable differences in the levels of some mRNAs. The physiological significance of up- or downregulation of host genes for AR9 phage infection remains to be established. AR9 infection is significantly affected by rifampin, an inhibitor of host RNA polymerase transcription. The effect is likely caused by the antibiotic-induced killing of host cells, while phage genome transcription is solely performed by viral RNA polymerases.
The work proposes possible designs of active regions for a mode-locked interband cascade laser emitting in the mid infrared. For that purpose we investigated the electronic structure properties of respectively modified GaSb-based type II W-shaped quantum wells, including the effect of external bias in order to simultaneously fulfil the requirements for both the absorber as well as the gain sections of a device. The results show that introducing multiple InAs layers in type II InAs/GaInSb quantum wells or introducing a tensely-strained GaAsSb layer into “W-shaped” type II QWs offers significant difference in optical transitions’ oscillator strengths (characteristic lifetimes) of the two oppositely polarized parts of such a laser, being promising for utilization in mode-locked devices.
Eu\(^{3+}\)-modified carbon dots (C-dots), 3–5 nm in diameter, were prepared, functionalized, and stabilized via a one-pot polyol synthesis. The role of Eu\(^{2+}\)/Eu\(^{3+}\), the influence of O\(_2\) (oxidation) and H\(_2\)O (hydrolysis), as well as the impact of the heating procedure (conventional resistance heating and microwave (MW) heating) were explored. With the reducing conditions of the polyol at the elevated temperature of synthesis (200–230 °C), first of all, Eu\(^{2+}\) was obtained resulting in the blue emission of the C-dots. Subsequent to O\(_2\)-driven oxidation, Eu\(^{3+}\)-modified, red-emitting C-dots were realized. However, the Eu\(^{3+}\) emission is rapidly quenched by water for C-dots prepared via conventional resistance heating. In contrast to the hydroxyl functionalization of conventionally-heated C-dots, MW-heating results in a carboxylate functionalization of the C-dots. Carboxylate-coordinated Eu\(^{3+}\), however, turned out as highly stable even in water. Based on this fundamental understanding of synthesis and material, in sum, a one-pot polyol approach is established that results in H\(_2\)O-dispersable C-dots with intense red Eu\(^{3+}\)-line-type emission.
There is a great need for valuable ex vivo models that allow for assessment of cartilage repair strategies to reduce the high number of animal experiments. In this paper we present three studies with our novel ex vivo osteochondral culture platform. It consists of two separated media compartments for cartilage and bone, which better represents the in vivo situation and enables supply of factors pecific to the different needs of bone and cartilage. We investigated whether separation of the cartilage and bone compartments and/or culture media results in the maintenance of viability, structural and functional properties of cartilage tissue. Next, we valuated for how long we can preserve cartilage matrix stability of osteochondral explants during long-term culture over 84 days. Finally, we determined the optimal defect size that does not show spontaneous self-healing in this culture system. It was demonstrated that separated compartments for cartilage and bone in combination with tissue-specific medium allow for long-term culture of osteochondral explants while maintaining cartilage viability, atrix tissue content, structure and mechanical properties for at least 56 days. Furthermore, we could create critical size cartilage defects of different sizes in the model. The osteochondral model represents a valuable preclinical ex vivo tool for studying clinically relevant cartilage therapies, such as cartilage biomaterials, for their regenerative potential, for evaluation of drug and cell therapies, or to study mechanisms of cartilage regeneration. It will undoubtedly reduce the number of animals needed for in vivotesting.