Refine
Has Fulltext
- yes (576)
Year of publication
- 2016 (576) (remove)
Document Type
- Journal article (576) (remove)
Keywords
- inflammation (7)
- vision (7)
- Drosophila melanogaster (6)
- Fabry disease (6)
- breast cancer (6)
- phosphorylation (6)
- genetics (5)
- mice (5)
- DNA methylation (4)
- Drosophila (4)
- Pain (4)
- chronic kidney disease (4)
- deep brain stimulation (4)
- event-related potentials (4)
- gene expression (4)
- heterochromatin (4)
- immunofluorescence (4)
- lymphocytes (4)
- oxidative stress (4)
- 5-Methylcytosine (3)
- Boron (3)
- Cancer genetics (3)
- DNA (3)
- DNA damage (3)
- Enzyme replacement therapy (3)
- LHC (3)
- MRI (3)
- Myelin oligodendrocyte glycoprotein antibodies (MOG-IgG) (3)
- NLO Computations (3)
- Neuromyelitis optica spectrum disorders (NMOSD) (3)
- Optic neuritis (3)
- Staphylococcus aureus (3)
- Treatment (3)
- Trypanosoma brucei (3)
- attention (3)
- biodiversity (3)
- biomarker (3)
- c-Fos (3)
- case report (3)
- circadian rhythms (3)
- collagens (3)
- colorectal cancer (3)
- cytokines (3)
- dopamine (3)
- electronic properties and materials (3)
- flow cytometry (3)
- humans (3)
- hyperexpression techniques (3)
- ischemic stroke (3)
- metabolism (3)
- monocytes (3)
- multiple sclerosis (3)
- ovarian cancer (3)
- platelets (3)
- polymers (3)
- prostate cancer (3)
- sRNA (3)
- AAA (2)
- ADHD (2)
- Adult (2)
- Antisense RNA (2)
- Anura (2)
- Apoptosis (2)
- Aspergillus fumigatus (2)
- Autism spectrum disorders (2)
- Autoantibodies (2)
- B cells (2)
- BDNF (2)
- Bone-marrow-transplantation (2)
- CMV (2)
- Candida albicans (2)
- Carcinogenicity (2)
- Cell therapy (2)
- Cells (2)
- Central nervous system (2)
- Cerebrospinal fluid (2)
- Chemotherapy (2)
- Diagnosis (2)
- Digital Humanities (2)
- Dionaea muscipula (2)
- Diseases (2)
- Down syndrome (2)
- Dyes (2)
- EEG (2)
- Enzyme induction (2)
- Expression (2)
- Fluorescence (2)
- Gene (2)
- Genetics research (2)
- Genome (2)
- Germany (2)
- Guidelines (2)
- HIV (2)
- HKT transporter (2)
- Humans (2)
- IAPS (2)
- In-vitro (2)
- Infections (2)
- Inflammation (2)
- Literatur (2)
- Longitudinally extensive transverse myelitis (LETM) (2)
- MDD (2)
- MEG (2)
- MODIS (2)
- MRSA (2)
- MS (2)
- Mechanisms (2)
- Merkel cell carcinoma (2)
- Metabolism (2)
- Mice (2)
- Model (2)
- Multiple bonds (2)
- Multiple sclerosis (2)
- Neurotrophic factors (2)
- Outcome survey (2)
- P300 (2)
- PET (2)
- PRRT (2)
- Parkinson's disease (2)
- Parkinson’s disease (2)
- Phase-II (2)
- RNA interference (2)
- Randomized controlled-trial (2)
- Rehabilitation (2)
- Relapse (2)
- Reproductive toxicity (2)
- Silicones (2)
- Spermatogenesis (2)
- Systems (2)
- Textanalyse (2)
- Therapy (2)
- Thyroid cancer (2)
- Transcriptome (2)
- Validation (2)
- absorption spectra (2)
- activation (2)
- adaption (2)
- adenosine (2)
- adulthood (2)
- adversity (2)
- animal behavior (2)
- animal model (2)
- antagonist (2)
- apoptosis (2)
- arabidopsis thaliana (2)
- bacteria (2)
- behavioral conditioning (2)
- bevacizumab (2)
- biological locomotion (2)
- biology (2)
- biomarkers (2)
- c-Myc (2)
- cancer treatment (2)
- cardiac hypertrophy (2)
- cardiomyopathy (2)
- change detection (2)
- chemotherapy (2)
- children (2)
- circadian clock (2)
- condensed matter physics (2)
- crystal structure (2)
- cytotoxicity (2)
- database (2)
- detoxification (2)
- diffusion (2)
- discussion report (2)
- disease (2)
- electroencephalography (2)
- environmental exposure (2)
- enzyme replacement therapy (2)
- epithelial cells (2)
- excited states (2)
- exercise (2)
- extracellular matrix (2)
- eye movements (2)
- fear (2)
- fear conditioning (2)
- fluorescence (2)
- fluorescence microscopy (2)
- gastric cancer (2)
- gene-expression (2)
- genome (2)
- genotype (2)
- heat stress (2)
- honey bees (2)
- host-pathogen interactions (2)
- imaging (2)
- in-vivo (2)
- innate immune system (2)
- insect brain (2)
- insulin (2)
- interaction (2)
- learning (2)
- leukemia (2)
- lipidomics (2)
- lung cancer (2)
- lyso-Gb3 (2)
- macrophage (2)
- macrophages (2)
- magnetic resonance imaging (2)
- mammalian genomics (2)
- maternal exposure (2)
- memory (2)
- men who have sex with men (2)
- metallic trace elements (2)
- microRNA (2)
- mouse (2)
- mouse models (2)
- movement disorders (2)
- multiple myeloma (2)
- mushroom body (2)
- mutation (2)
- natural language processing (2)
- neuroinflammation (2)
- neuromelanin (2)
- neuronal plasticity (2)
- neurons (2)
- neutrino astronomy (2)
- next generation sequencing (2)
- nonsmooth optimization (2)
- obesity (2)
- pain (2)
- pancreatic cancer (2)
- panic disorder (2)
- parietal hypoactivation (2)
- perception (2)
- photoperiodism (2)
- phylogenetic trees (2)
- plants (2)
- platelet activation (2)
- platelet aggregation (2)
- potassium (2)
- prenatal exposure (2)
- protein expression (2)
- protein-protein interaction (2)
- quantum dots (2)
- quantum mechanics (2)
- quantum physics (2)
- receptor tyrosine kinases (2)
- rehabilitation (2)
- repositories (2)
- retinoblastoma protein (2)
- risk factors (2)
- salinity stress (2)
- schizophrenia (2)
- semiconductors (2)
- sequestration (2)
- serotonin (2)
- serotonin transporter (2)
- sexual selection (2)
- signaling (2)
- simulation (2)
- sodium (2)
- solar cells (2)
- spintronics (2)
- stem cells (2)
- surfactants (2)
- synapses (2)
- temperature (2)
- temporoparietal junction (2)
- tissue engineering (2)
- tool (2)
- topological insulators (2)
- transcription factors (2)
- visualization (2)
- walking (2)
- xylem loading (2)
- (yo) pienso (que) (1)
- 12-oxo-phytodienoic acid (1)
- 177Lu (1)
- 18F-FDG PET/CT (1)
- 1H-Magnetic resonance spectroscopy (1H-MRS) (1)
- 1st-line treatment (1)
- 2-Generation reproduction (1)
- 2-loop level (1)
- 2-photon absorption (1)
- 2-step IMRT (1)
- 2015 (1)
- 3D fluoroscopy (1)
- 3D mapping (1)
- 3D object recognition (1)
- 5-Fluorouracil (1)
- 5-HTT knockout mice (1)
- 5-HTTLPR (1)
- 6-percent hydroxyethyl starch (1)
- AC Stark effect (1)
- AIDS (1)
- AIRWAYS ICPs (1)
- ANTARES telescope (1)
- AP-1 (1)
- ARIA (1)
- AT/RT (1)
- Abuse (1)
- Action potentials (1)
- Activation (1)
- Acute lymphocytic leukaemia (1)
- Acyrthosiphon pisum (1)
- Adamantiades-Behçet disease (1)
- Addison's disease (1)
- Adipokine (1)
- Adolescence (1)
- Adolescents (1)
- Adrenocortial carcinomas (1)
- Adult patients (1)
- Affective processing (1)
- Ag-DNA (1)
- Agalsidase beta (1)
- Aggression (1)
- Aggressive behaviour (1)
- Aging (1)
- Agnant, Marie-Célie : Le livre d'Emma (1)
- Agoraphobia (1)
- Agricultural intensification (1)
- Albrecht von Johansdorf (1)
- Alpha therapy (1)
- Alpha-Galactosidase (1)
- Alpha-synuclein oligomers (1)
- Alternative test methods (1)
- Alvis (1)
- Alzheimer disease (1)
- Alzheimer's disease (1)
- Alzheimers disease (1)
- Alzheimers-disease (1)
- Alzheimer’s disease (1)
- Amphibians (1)
- Amplification (1)
- Amygdala (1)
- Amyloid-beta oligomers; (1)
- Amyotrophic-lateral-sclerosis (1)
- Anas crecca (1)
- Anderson-Fabry Disease (1)
- Angiopoietin-2 (1)
- Angiopoietin-like 4 (1)
- Animal models (1)
- Annotation (1)
- Anorexia nervosa (1)
- Antibody index (1)
- Antisocial behavior (1)
- Anxiety (1)
- Anxiety sensitivity (1)
- Aphthae (1)
- Aquaporin-4 antibodies (AQP4-Ig, NMO-IgG)G (1)
- Aquaporin-4 antibodies (AQP4-IgG) (1)
- Aquaporin-4 antibodies (AQP4-IgG, NMO-IgG) (1)
- Arabidopsis (1)
- Arabidopsis thaliana (1)
- Arabidopsis-thaliana (1)
- Archaea (1)
- Aromatic-hydrocarbon (1)
- Aromaticity (1)
- Arthropods (1)
- Assay (1)
- Association (1)
- Ataxia (1)
- Atomic force microscopy (1)
- Atrial natriuretic peptide (1)
- Attentat (1)
- Attention Deficit Hyperactivity Disorder (ADHD) (1)
- Auskunftsdienst (1)
- Autism (1)
- Autoimmune diseases (1)
- Autoimmunity (1)
- Autoinflammation (1)
- Aversive events (1)
- Aversive tension (1)
- Avoidance behavior (1)
- Axon degeneration (1)
- Axon growth (1)
- Axon guidance (1)
- Axonal transport (1)
- Azathioprine (1)
- B cell (1)
- B-B bond (1)
- B-cells (1)
- BCL6 (1)
- BDLP (1)
- BDNF Val66Met (1)
- BMP-2 (1)
- BMP-2 delivery (1)
- BRAF (1)
- BRCA1 (1)
- BRCA1/2 (1)
- BRCA2 (1)
- BRENDA (1)
- BSTA (1)
- Babylotse-Plus (1)
- Bacteria (1)
- Bacterial meningitis (1)
- Bacterial symbionts (1)
- Banda desenhada de língua portuguesa (1)
- Barkhof criteria (1)
- Barratt Impulsiveness Scale (1)
- Bataclan (Paris) (1)
- Bee abundance (1)
- Behçet’s disease (1)
- Berlioz, Hector (1)
- Berlusconi, Silvio (1)
- Berry phase (1)
- Beta-catenin (1)
- Big picture (1)
- Biocompatibility (1)
- Biodegradable polymer scaffolds (1)
- Biogenic (1)
- Biographisches Interview (1)
- Biradicals (1)
- Blood pressure (1)
- Bone disease (1)
- Bone marrow transplantantation (1)
- Bone morphogenetic protein-2 (1)
- Bone tissue engineering (1)
- Bor (1)
- Bose gas (1)
- Bose-Fermi (1)
- Bound-states (1)
- Bradyrhizobium (1)
- Bragg-reflection waveguide (1)
- Brain (1)
- Brain Computer Interface (1)
- Brainstem encephalitis (1)
- Breaking (1)
- Breast cancer (1)
- Breath tests (1)
- Broca (1)
- B‐cell lymphoma (1)
- C2-toxin (1)
- CA19-9 (1)
- CD11b+ myeloid cells (1)
- CD39 (1)
- CD73 (1)
- CD8 (1)
- CDH13 Expression (1)
- CDH13 mRNA (1)
- CHIP (1)
- CKD (1)
- CML (1)
- COD movements (1)
- COPD (1)
- CO\(_{2}\) exposure (1)
- CO\(_{2}\) signaling (1)
- CSF (1)
- CSI (1)
- Cadherin (CDH13) (1)
- Calcineurin-NFATsignaling (1)
- Campylobacter jejuni (1)
- Canada (1)
- Cancer (1)
- Carbon (1)
- Carcinoma cells (1)
- Cardiology (1)
- Cardiovascular disease (1)
- Cardiovascular magnetic-resonance (1)
- Case-Control Studies (1)
- Cell lung canger (1)
- Cell replacement therapy (1)
- Cell reprogramming (1)
- Cell signalling (1)
- Cell-based assays (1)
- Cellular prion protein (1)
- Central hyperactivity (1)
- Central nervous system infection (1)
- Central venous-pressure (1)
- Ceramide (1)
- Cerebellitis (1)
- Cerebral-ischemia (1)
- Cervical cancer (1)
- ChIP-sequencing (1)
- Charcot-Marie-Tooth (1)
- Chemerin (1)
- Chemerin processing (1)
- Chemicals (1)
- Child Maltreatment (1)
- Child welfare (1)
- Childhood (1)
- Childhood medulloblastoma (1)
- Childrens-cancer (1)
- China (1)
- Chlorophyll fluorescence (1)
- Chromophores (1)
- Chromosomes (1)
- Chronic kidney disease (1)
- Chronic neuropathic pain (1)
- Chronic respiratory diseases (1)
- Chronic stress (1)
- Cimex lectularius (1)
- Clinical Genetics (1)
- Clinical practice guidelines (1)
- Clinical remission (1)
- Clinical trial (1)
- Cocalodinae (1)
- Cognitive Therapy (1)
- Cohort study (1)
- Coleoptera: Chrysomelidae (1)
- Collaboration (1)
- Colony growth (1)
- Combinatorial Background (1)
- Conditioning evidence (1)
- Conduct disorder (1)
- Conjugate arc therapy (1)
- Conjugated polymers (1)
- Connectivity (1)
- Context (1)
- Contextual fear (1)
- Contrast-enhanced CT (1)
- Cooperation (1)
- Copaxone® (1)
- Coronary artery disease (1)
- Cortical plasticity (1)
- Cotransporter 2 inhibition (1)
- Couch tracking (1)
- Critically-ill patients (1)
- Cruzi (1)
- Cvi-0 (1)
- Cyclic GMP (1)
- Cyclic electron transport (1)
- Cycloaddition (1)
- Cystic-fibriosis (1)
- Cytokine GM-CSF (1)
- Cytokine receptors (1)
- Cytokines (1)
- Cytoskeleton (1)
- Cytotoxic (1)
- Cytotoxic T lymphocytes (1)
- D313Y genotype (1)
- DAMGO (1)
- DARPA (1)
- DNA Methylation (1)
- DNA binding (1)
- DNA metabolism (1)
- DNA methylation dynamics (1)
- DNA sequencing (1)
- DNA-based species delimitation (1)
- DNA-encapsulated silver nanoclusters (1)
- DOTATOC (1)
- DPF3a (1)
- DYT1 (1)
- Danio-rerio (1)
- Dante, Alighieri (1)
- Dark Matter (1)
- De Miseria Condicionis Humanae (1)
- Deficit/hyperactivity disorder (1)
- Dendritic cells (1)
- Densities (1)
- Dentate granule cells (1)
- Deschamps, Eustache (1)
- Design (1)
- Deutschunterricht (1)
- Devic syndrome (1)
- Devic’s syndrome (1)
- Diabetes mellitus (1)
- Diagnostic accuracy (1)
- Diagnostic approach (1)
- Diagnostische Genauigkeit (1)
- Diborane (1)
- Dictyostelium discoideum (1)
- Differential RNA-sequencing (1)
- Digitalisierung (1)
- Digitization (1)
- Diisononyl phthalate (1)
- Dimers (1)
- Dionaea-muscipula ellis (1)
- Diplopia Internuclear ophthalmoplegia (INO) (1)
- Disease gene prioritization (1)
- Disease genetics (1)
- Disease prevalence (1)
- Diskursanalyse (1)
- Diskursmarker (1)
- Distress (1)
- Diversity (1)
- Dorsolateral prefrontal cortex (1)
- Dose reduction (1)
- Double lay de fragilité humaine (1)
- Double-blind (1)
- Draize eye test (1)
- Drosha (1)
- Drosophilia (1)
- Drug development (1)
- Drug metabolism (1)
- Drug-free remission (1)
- Duchenne muscular dystrophy (1)
- Dystonia (1)
- E3 ligase (1)
- EANM (1)
- EBV (1)
- EDS (1)
- EIP on AHA (1)
- ELISPOT (1)
- ESTARFM (1)
- EU‐RHAB Registry (1)
- Early posterior negativity (1)
- Early prevention (1)
- Early prevention program (1)
- Eating disorder (1)
- Echeverría, Esteban (1)
- Eco, Umberto : Il nome della rosa (1)
- Ecological momentary assessment (1)
- Ecologically important traits (1)
- Edema (1)
- Effectors in plant pathology (1)
- Ehlers-Danlos syndrome (1)
- Ekel (1)
- Elective cesarean-section (1)
- Electroencephalography (1)
- Electrophysiology (1)
- Embryonic stem cell (1)
- Emission (1)
- Emotion (1)
- Emotion regulation (1)
- Emotional expression (1)
- Endothelial growth-factor (1)
- Endothelium (1)
- Energy depletion (1)
- Energy transfer (1)
- Entanglement (1)
- Entente Cordiale (1)
- Enteric nervous system (1)
- Enteric neuropathies (1)
- Enterovirus (1)
- Entstehungsgeschichte (1)
- Environment (1)
- Environmental enrichment (1)
- Epidemiological study (1)
- Epidemiology (1)
- Epidermal growth-factor (1)
- Epidermis (1)
- Epigenesis (1)
- Epigenetics (1)
- Episkin (1)
- Epitaxy (1)
- Epitope (1)
- Escherichia coli K1 (1)
- Ethanol (1)
- European Innovation Partnership on Active and Healthy Ageing (1)
- Event (1)
- Event-related potential (1)
- Evoked potentials (1)
- Exciton-polariton condensate (1)
- Excitons (1)
- Exercise (1)
- Exosome (1)
- Extracorporeal Membrane Oxygenation (1)
- Eye gaze (1)
- F-18-FDG PET/CT (1)
- FANCM (1)
- FE (1)
- FISH-CLEM (1)
- FOLFIRI (1)
- FOLFOX (1)
- FP-CIT SPECT (1)
- FRET (1)
- FRET sensors (1)
- FT-IR spectroscopy (1)
- FWGE (1)
- FXIIa inhibitor rHA-Infestin (1)
- Fabry cardiomyopathy (1)
- Fabry nephropathy (1)
- Fabry-associated pain (1)
- Faces and scenes (1)
- Facial nerve palsy (1)
- Factor receptor (1)
- Familial Alzheimers-disease (1)
- Families (1)
- FeS proteins (1)
- Female (1)
- Fermi liquid (1)
- Ferrite (1)
- Fetal brain development (1)
- Fibroblasts (1)
- Ficaria calthifolia (1)
- Ficaria verna (1)
- Fiels-effect transistors (1)
- Fischer 344 rats (1)
- Flash relaxation kinetics (1)
- Flow cytometry (1)
- Fluorescein angiography (1)
- Fluorouracil (1)
- Foragers (1)
- Forschungsinfrastruktur (1)
- Fourier-transform spectroscopy (1)
- FoxQ2 (1)
- Frequency-response areas (1)
- Fresh Freeze Plasma (1)
- Friedrich von Hausen (1)
- Frontal cortex (1)
- Frühe Hilfen (1)
- Functionalization (1)
- Fungal (1)
- Fungal host response (1)
- Funktion (1)
- Förster resonance energy transfer (1)
- G Protein (1)
- G protein coupled receptors (1)
- G-protein coupled receptors (1)
- GABP (1)
- GLA mutation (1)
- GPCR (1)
- GWAS (1)
- GaAsSb (1)
- Gadda, Carlo Emilio : Quer pasticciaccio brutto de Via Merulana (1)
- Galactic Ridge (1)
- Galactosidase-A gene (1)
- Gamma (1)
- Gaze perception (1)
- Gedicht (1)
- Gene expression profiling (1)
- Gene-expression (1)
- Genetic (1)
- Genitoanal region (1)
- Genome assembly (1)
- Genome comparison (1)
- Genome re-annotation (1)
- Genome-wide association studies (1)
- Genomics data sets (1)
- Genotype–phenotype correlations (1)
- German crusade poetry (1)
- Gifsy-1 (1)
- Gimbaled tracking (1)
- Glatiramer acetate (1)
- Glucose metabolism (1)
- Glucose uptake (1)
- Glucosyltransferase (1)
- Glutamatergic synapses (1)
- Glutathione (1)
- GlyR receptors (1)
- Glycaemic control (1)
- Goethe, Johann Wolfgang von (1)
- Golgi (1)
- Gott <Motiv> (1)
- Graft versus Tumor (1)
- Graft-versus-leukemia (1)
- Graphene nanoribbons (1)
- Group B Streptococcus (1)
- Growth; BMP-2 (1)
- Guanylyl cyclase-A (1)
- Guideline (1)
- Guillain-Barré-Syndrom (1)
- Guinea pig model (1)
- Gα\(_{i1}\), Gα\(_{i2}\) and Gα\(_{i3}\) activation (1)
- H-1-NMR spectroscopy (1)
- HEY repressors (1)
- HFpEF (1)
- HFrEF (1)
- HIV infection (1)
- HIV infections (1)
- HIV neurocognitive impairment (1)
- HIV-1 subtype AG (1)
- HKT1 (1)
- HPV (1)
- Habitats (1)
- Haloferax volcanii (1)
- Hamburg (1)
- Hartmann von Aue (1)
- Head-injury (1)
- Health-care (1)
- Hearing loss (1)
- Hearing-loss (1)
- Heart (1)
- Helicobacter pylori (1)
- Hellenistisch-jüdische Literatur (1)
- Hemodynamic depression (1)
- Hemoglobin A1C (1)
- Hepatitis B virus (1)
- Hepatitis C (1)
- Hermopolis (1)
- Herpes simplex encephalitis (1)
- Herpes simplex virus (1)
- Heterocycles (1)
- Heterocyclische Verbindungen (1)
- Higgs Boson (1)
- Higgs Mass (1)
- Higgs-boson (1)
- High efficiency (1)
- High performance (1)
- High-dose chemotherapy (1)
- High-spontaneous rate (1)
- Highlights Lecture (1)
- Hippocampus (1)
- Hirschsprung disease (1)
- Hirschsprung disease liability (1)
- Hispanoamerika (1)
- Histologic grade (1)
- Hoechst 33342 (1)
- Hollande, François (1)
- Homeostatic plasticity (1)
- Horizontal transfer (1)
- Hormesis (1)
- Hospitalization (1)
- Host adaptation (1)
- Hsp90 (1)
- Hueter interval (1)
- Human CDH13 (1)
- Human Physiome (1)
- Human Resource Management (1)
- Human and murine cancer cells (1)
- Human immunodefiency virus (1)
- Human prefrontal cortex (1)
- Hydrogen-peroxide (1)
- Hydroxymethyluracil (1)
- Hymenoptera (1)
- Hypertonic saline 7.5-percent (1)
- Hypertrophic cardiomyopathy (1)
- Hypertrophic pyloric-stenosis (1)
- IBA-1 (1)
- IGRT (1)
- IL-1 beta (1)
- IL-1 blockade (1)
- IL-10 (1)
- IL-12 family (1)
- IMAT (1)
- IMRT (1)
- IPND criteria (1)
- IVIg (1)
- Identification (1)
- IgE (1)
- IgE sensitazion (1)
- Illumina Human Exome Bead Chip (1)
- Image interpretation (1)
- Imatinib (1)
- Immune tolerance (1)
- Immunocompromised patient (1)
- Immunotherapy (1)
- In vitro skin irritation testing (1)
- In-vivo (1)
- InSAR (1)
- Incomplete contracts (1)
- Incunabula (1)
- Indian muntjac (1)
- Inferior Vena Cava (1)
- Inferior colliculus (1)
- Infliximab (1)
- Influenzae type B (1)
- Information (1)
- Information Integration Theory (1)
- Inhibitory glycine receptor (1)
- Inkunabel (1)
- Inner hair cell (1)
- Innocent III (1)
- Insect hosts (1)
- Insects (1)
- Insulating thin films (1)
- Insulator surfaces (1)
- Insulin therapy (1)
- Intelligent mobile system (1)
- Intensity (1)
- Interactive Tree Of Life (iTOL) (1)
- Interband cascade lasers (1)
- Interferon beta (1)
- Interleukin IL-6 (1)
- Intermedialität (1)
- Intermediate filaments (1)
- Internal transcription start site (1)
- International consensus diagnostic criteria for neuromyelitis optica spectrum disorders (1)
- Intervention (1)
- Interview (1)
- Intestinal pseudoobstruction (1)
- Intracellular domain (1)
- Intractable nausea and vomiting (1)
- Intravascular coagulation (1)
- Invasion (1)
- Invasive Aspergillosis (1)
- Invasive fungal-infections (1)
- Iran (1)
- IsrK (1)
- JR11 (1)
- Jak kinases (1)
- Janus kinase (1)
- Japan (1)
- Japoneries d’automne (1)
- Jasmonate perception (1)
- Jasmonic acid (1)
- Joint ownership (1)
- Josephson effect (1)
- Joubert syndrome (1)
- Jurkat T cells (1)
- Jurkat cells (1)
- K2–K model (1)
- KAT/HAT (1)
- Karyotyp (1)
- Kenyon cells (1)
- Kidney function (1)
- Kiesler, Reinhard (1)
- Kinderschutz (1)
- Kohlberg (1)
- Kooperation (1)
- Kriegspolitik (1)
- Kriegsvorbereitung (1)
- Körper (1)
- Künstler (1)
- Künstlerkooperation (1)
- L. reuteri (1)
- LASP1 (1)
- LED (1)
- LIN-5 (1)
- LITAF (1)
- LPS (1)
- Lacking neurofilaments (1)
- Lactated ringers solution (1)
- Lag time (1)
- Landsat (1)
- Large T antigen (1)
- Large multicenter ADHD (1)
- Latin America (1)
- Leaderless transcript (1)
- Lectins (1)
- Leiche (1)
- Lepidoptera (1)
- Light Supersymmetric Particle (1)
- Light-emitting diodes (1)
- Lipid (1)
- Lipid metabolism (1)
- Liposomal amphotericin-B (1)
- Liquid-crystalline (1)
- Literarisierung (1)
- Liver cirrhosis (1)
- Localized states (1)
- Locomotor activity (1)
- Locus (1)
- Long-range order (1)
- Longitudinally extensive transverse myelitis (1)
- Loti, Pierre (1)
- Low-dose acyclovir (1)
- LpxC inhibitors (1)
- Luxembourg (1)
- Lynx lynx (1)
- MACVIA (1)
- MAG3 (1)
- MAPK pathway (1)
- MDSCs (1)
- MHC class I chain-related protein (1)
- MIZ1 (1)
- MLC tracking (1)
- MMQ cells (1)
- MOG-IgG (1)
- MPACT (1)
- MPK12 (1)
- MR (1)
- MRI criteria (1)
- MSSM (1)
- MU-M (1)
- MYC (1)
- MYCN (1)
- Macrophage (1)
- Madame Chrysanthème (1)
- Magnetic resonance imaging (1)
- Major abdominal surgery (1)
- Male breast cancer (1)
- Male intromittent organ (1)
- Malignant melanoma (1)
- Management (1)
- Mandibular condyle (1)
- Mandibular continuity defects (1)
- Manifestation (1)
- Marcus inverted region (1)
- Marrow stromal cells (1)
- Mass (1)
- Mast cells (1)
- Matrix (1)
- McDonald criteria (1)
- Medical overuse (1)
- Medical students (1)
- Medicalization (1)
- Medulloblastoma (1)
- Meiji-Periode (1)
- Meinungsbildung (1)
- Meiosis (1)
- Melanoma B16 (1)
- Mellitus (1)
- Meningococcal serogroup C (1)
- Meningococci (1)
- Mesenchymal stem cells (1)
- Mesenchymal stem/stromal cells (1)
- Mesenchymal transition (1)
- Mesocestoides corti (1)
- Messenger RNA (1)
- Methicillin resistant Staphylococcus aureus (1)
- Methodological quality (1)
- Methotrexate (1)
- Methylation (1)
- Methylome (1)
- MgAl LDH (1)
- Microcavity (1)
- Microenvironment (1)
- Microorganisms (1)
- Microtubules (1)
- Mid-infrared photoluminescence (1)
- Midline (1)
- Mindfulness (1)
- Minimal supersymmetric model (1)
- Missense mutation (1)
- Mitomycin C (1)
- Mitsunobu (1)
- Mittelalter (1)
- Molecular Imaging (1)
- Molecular beam epitaxy (1)
- Molecular-dynamics (1)
- Molecular-weight heparin (1)
- Molecules (1)
- Monoamine Oxidase/genetics (1)
- Morbus Fabry (1)
- Morphotype (1)
- Mortality (1)
- Motivation (1)
- Motoneuron disease (1)
- Mouse model (1)
- Mt. Kinabalu (1)
- Mud (1)
- Multibranched structures (1)
- Multicenter randomized-trial (1)
- Multiple drug resistance (1)
- Multiple myeloma (1)
- Musik (1)
- Mutations (1)
- Myelin oligodendrocyte glycoprotein (MOG) antibodies (1)
- Myelitis (1)
- Myeloma (1)
- Myocardial fibrosis (1)
- Myocardial perfusion (1)
- Müller cells (1)
- Mündliche Überlieferung (1)
- N-Myc (1)
- N-heterocyclic carbenes (1)
- N-oleoyl serinol (1)
- N100 (1)
- N170 (1)
- NDI-H (1)
- NEUROWIND (1)
- NFkB-relatedgenes (1)
- NGS (1)
- NK cells (1)
- NLO computations (1)
- NMD (1)
- NMO-IgG (1)
- NMOSD (1)
- NMR (1)
- NMR-spectroscopy (1)
- NO (1)
- NPU (1)
- NSCLC (1)
- NSG mice (1)
- Nachruf (1)
- Nanda-Hamner (1)
- Nanoparticles (1)
- Nasonia courtship (1)
- Natalizumab (1)
- Natural Language Processing (1)
- Natural-history data (1)
- Neisseria gonorrhoeae (1)
- Neisseria meningitidis (1)
- Nesting resources (1)
- Netrin (1)
- Network (1)
- Networking (1)
- Neural crest cells (1)
- Neurofilament (1)
- Neuroinfectiology (1)
- Neuromyelitis optica (NMO) (1)
- Neuromyelitis optica antibodies (NMO-IgG) (1)
- Neurosciences (1)
- Neurotropathic Factor (1)
- Neutrino Telescope (1)
- Neutrophil (1)
- Nils Mohl (1)
- Nitric-oxide (1)
- Nodule (1)
- Non-coding RNAs (1)
- Normal breast (1)
- Nrf2 (1)
- NuMA (1)
- Nurses (1)
- OCB (1)
- OCR (1)
- OCSVM (1)
- OCT angiography (1)
- OECD guideline (1)
- OPS201 (1)
- Oesling (1)
- Ofatumumab (1)
- Oilseed rape (1)
- Olfr1393 (1)
- Oligoclonal bands (1)
- Oncology (1)
- Oncolytic action (1)
- One-photon (1)
- Oogenesis (1)
- Open source reconstructed epidermis (1)
- Openfield test (1)
- Opsins (1)
- Optical properties (1)
- Oral antidiabetic drugs (1)
- Oral squamous cell carcinoma (1)
- Organ motion (1)
- Osteoarthritis (1)
- Osteoarthrosis (1)
- Osteogenic precursor cells (1)
- Outcome (1)
- Overdiagnosis (1)
- Oxidative stress (1)
- Oxide synthase gene (1)
- Oxygen (1)
- Oxyrhynchos (1)
- P300 speller (1)
- P75 Neurotrophin receptor (1)
- PARROT (1)
- PBI cyclophane (1)
- PDE (1)
- PDGF (1)
- PET/CT (1)
- PI3K isoforms (1)
- PI3K/Akt/mTOR (1)
- PICD (1)
- PKB/Akt phosphorylation (1)
- PSMA (1)
- PUMP (1)
- Paediatric (1)
- Palladium-catalyzed silaboration (1)
- Panic Disorder/genetics (1)
- Panic Disorder/therapy (1)
- Parametric down-conversion (1)
- Parasite (1)
- Parkinson disease (1)
- Pathogenicity (1)
- Pathogens (1)
- Pathology (1)
- Pathway (1)
- Patient-centered care (1)
- Patterns (1)
- Peptidase inhibitor 16 (PI16) (1)
- Peptidoglycan recognition (1)
- Peripheral nervous system (1)
- Perovskite (1)
- Personality (1)
- Perspektive (1)
- Phosphorylation (1)
- Photochemistry (1)
- Photosystem I (1)
- Physics and instrumentation (1)
- Pierre Loti (1)
- Pinus sylvestris L. (1)
- Pitrakinra (1)
- Placebo (1)
- Placebo-controlled trial (1)
- Plant utricularia-gibba (1)
- Plants (1)
- Plasma extravasation (1)
- Plasma-membrane (1)
- Pleistocene (1)
- Pluripotency (1)
- Pneumococci (1)
- Pneumocystis-carinii-pneumonia (1)
- Podocarpus National Park (1)
- Poecilia reticulata (1)
- Polarimetric Synthetic Aperture Radar (PolSAR) (1)
- Polistine wasps (1)
- Politische Rede (1)
- Polycistronic mRNA (1)
- Polymerase chain raction (1)
- Polyphasic fluorescence rise (1)
- Polyphenols (1)
- Poor-prognosis (1)
- Porphyrin arrays (1)
- Positron-emission-tomography (1)
- Potential-energy curves (1)
- Pou2af1 (1)
- Preclinical evaluation (1)
- Predict fluid responsiveness (1)
- Pregnancy (1)
- Primary cell lines (1)
- Primary endosymbiont (1)
- Primitive neuroectodermal (1)
- Programmed cell-death (1)
- Progressive motor neuronopathy (1)
- Progressive multifocal leukoencephalopathy (1)
- Progressive supranuclear palsy (1)
- Prokura (1)
- Prolactin (1)
- Promoter (1)
- Promoter prediction (1)
- Property rights approach (1)
- Prostate-cancer (1)
- Protease inhibition (1)
- Protection (1)
- Protein (1)
- Protein function prediction (1)
- Protein kinase B (1)
- Protein transduction (1)
- Proteogenomics (1)
- Pulmonary Embolism (1)
- Pulmonary hypertension (1)
- Puls-pressure variation (1)
- Purification (1)
- QTL analysis (1)
- Qualitative representation and reasoning (1)
- Quantum wells (1)
- RARRES2 (1)
- RHE (1)
- RNA (1)
- RNA isolation (1)
- RNA polymerase (1)
- RNA sequencing (RNA-Seq) (1)
- RNA-SEQ data (1)
- RNA-binding proteins (1)
- RNA-seq (1)
- RNAseq (1)
- ROS (1)
- RU(CO)(3)CL(GLYCINATE) (1)
- RU-(II) complexes (1)
- Racial differences (1)
- Radarsat-2 (1)
- Radionuclide Therapy (1)
- Radionuclide therapy (1)
- Radiopharmacy (1)
- Radiotherapy (1)
- Rapid evolution (1)
- Rat (1)
- Rat mynteric plexus (1)
- Rating scale (1)
- Rats (1)
- RbdB (1)
- Reaction kinetics and dynamics (1)
- Real-time PCR (1)
- Recurrent medulloblastoma (1)
- Redox environment (1)
- Regenerative medicine (1)
- Regulatory T cells (1)
- Regulatory T-cells (1)
- Regulatory-cells (1)
- Reirradiation (1)
- Relapsing-remitting MS (1)
- Remotely Operate Vehicle (1)
- Renzi, Matteo (1)
- Reproduction (1)
- Research Infrastructure (1)
- Respiratory insufficiency (1)
- Respiratory syncytial virus (1)
- Responses (1)
- Retinal arterial macroaneurysms (1)
- Reveals (1)
- Rhabdoid 2007 (1)
- Rheumatoid arthritis (1)
- Rhodopsins (1)
- Rhombencephalitis (1)
- Richness (1)
- Rictor-mTOR complex (1)
- Risk (1)
- Rituximab (1)
- Robertsonian translocation chromosomes (1)
- Robotic tracking (1)
- Romanistik (1)
- Romansitik (1)
- Ru(II)–Fe(II)–Ru(II) complex (1)
- S-HT (1)
- SABR (1)
- SAP47 gene (1)
- SAR (1)
- SBRT (1)
- SCD (1)
- SCORE (1)
- SEM (1)
- SERT (1)
- SFRP (1)
- SGLT2 inhibitor (1)
- SPECT (1)
- SSRI (1)
- SSTR (1)
- STAT3 activation (1)
- SUMO2 (1)
- SVM (1)
- Saccharomyces cerevisiae (1)
- Salmonella Typhimurium (1)
- Salmonella enterica (1)
- Salmonella-enteritidis (1)
- Salvatore (1)
- Sap47 (1)
- Sarah (1)
- Scaling up (1)
- Schizophrenia (1)
- Schnitzler syndrome (1)
- Schwann cell dedifferentiation (1)
- Screening (1)
- Screening questionnaire (1)
- SdsR (1)
- Secondary tumours (1)
- Seeds (1)
- Selective attention (1)
- Selen (1)
- Selenium (1)
- Senescence (1)
- Sentinel-1 (1)
- Septal bulge (1)
- Sequence Analysis (1)
- Sequence identity (1)
- Si-rhodamine (1)
- Signal transduction (1)
- Simulations (1)
- Single nucleotide change (1)
- Sinorhizobium fredii (1)
- Sinus floor augmentation (1)
- Six3/6 Wnt (1)
- Skin (1)
- Skin cancer screening (1)
- Slow-transit constipation (1)
- Small fiber dysfunction (1)
- Smartphones (1)
- SnRK1 (1)
- Social anxiety (1)
- Social entrainment (1)
- Social support (1)
- Social work (1)
- Sound detection threshold (1)
- South Africa (1)
- Spectrum (1)
- Speedcourt (1)
- Spheno (1)
- Spin echo (1)
- Spinal Muscular-arthropy (1)
- Spontaneous facial EMG (1)
- Sprache (1)
- Sputter deposition (1)
- Squamous-cell carcinoma (1)
- Sracking (1)
- Stadtrandritter (1)
- Stage distribution (1)
- Stat3 (1)
- State (1)
- Stathmin (1)
- Stem cells (1)
- Stem cells plasticity (1)
- Strafrecht (1)
- Strafvollzug (1)
- Strains (1)
- Stratified scree (1)
- Streptococcus suis (1)
- Stress (1)
- Stress prevention (1)
- Stress responses (1)
- Stroke (1)
- Sturge-Weber syndrom (1)
- Supersymmetry Breaking (1)
- Suppression (1)
- Surface states (1)
- Survival (1)
- Survival analysis (1)
- Susceptibility loci (1)
- Sustainable HRM (1)
- Sustained attention (1)
- Syap1 localization (1)
- Synaptic plasticity (1)
- Synovitis (1)
- Synthetic Aperture Radar (SAR) (1)
- System involvement (1)
- T cell differentiation (1)
- T cells (1)
- T lymphocytes (1)
- T-cells (1)
- TBI (1)
- TCR diversity (1)
- TGF-β1 (1)
- TIG2 (1)
- TLR2 (1)
- TLR4 (1)
- TLR9 (1)
- TNF (1)
- TNFR2 (1)
- TNM staging (1)
- TRECs (1)
- TSPO (1)
- T\(_H\)17 cells (1)
- Tamm plasmons (1)
- Tanzania (1)
- Targeted therapy (1)
- Task force (1)
- Tellur (1)
- Tellurium (1)
- Temperature rhythms (1)
- Temporal-lobe epilepsy (1)
- Temporomandibular disorders (1)
- Temporomandibular joint disc (1)
- Term follow-up (1)
- Terminology (1)
- TerraSAR-X (1)
- Tesseract (1)
- Test accuracy (1)
- Text Encoding Initiative (1)
- Text analysis (1)
- Textedition (1)
- Th17 (1)
- Thigmotaxis (1)
- Thin film growth (1)
- Thioredoxin (1)
- Thrombus formation (1)
- TiO\(_2\) (1)
- Time Calibration (1)
- Time-course (1)
- Tissue (1)
- Tissue engineering (1)
- Toll-like receptors (1)
- Tourette syndrome (1)
- TraDIS (1)
- Trans-reservatrol (1)
- Transaction costs (1)
- Transcription (1)
- Transcription initiation (1)
- Transcription start site (1)
- Transferases (1)
- Transgenic mice (1)
- Transovarial transmission (1)
- Transport (1)
- Transposon insertion sequencing (1)
- Transverse Myelitis (1)
- Transverse myelitis (1)
- Tregs (1)
- Trial (1)
- Trinidadian guppy (1)
- Trypanosoma-brucei (1)
- Trypanosomes (1)
- Tumor-necrosis-factor (1)
- Tumorigenicity (1)
- Tumors (1)
- Type II quantum wells (1)
- Type-II quantum well (1)
- Typhimurium (1)
- Tyrosine phosphorylation (1)
- USP9X (1)
- UV/Vis spectroscopy (1)
- Ube2S (1)
- Ubiquitin-conjugating (E2) enzymes (1)
- Ulcerative colitis (1)
- Unionsbürgerschaft (1)
- Universitätsbibliothek Würzburg (1)
- Uterine tumors (1)
- Uveitis (1)
- VACV (1)
- VBM (1)
- VE-cadherin (1)
- VEGF (1)
- VMAT (1)
- Vaccination (1)
- Vaccine (1)
- Vaccinia virus (1)
- Vacuum chambers (1)
- Variants (1)
- Varicella-Zoster-Virus (1)
- Varicella-zoster-virus (1)
- Vascular plasticity (1)
- Venous Thrombosis (1)
- Ventricular-arrhythmias (1)
- Venusfliegenfalle (1)
- Vertical integration (1)
- Viability (1)
- Vibronic contributions (1)
- Vigilance (1)
- Viral (1)
- Virotherapy (1)
- Virtual-reality (1)
- Vivo (1)
- Vortices (1)
- W-boson (1)
- WDR5 (1)
- WIMP (1)
- Wallemia ichthyophaga (1)
- Weight (1)
- West Africa (1)
- Williamsia sp. ARP1 (1)
- Wilms tumor (1)
- Wingerchuk criteria 2006 and 2015 (1)
- Wnt signalling (1)
- Wolf-Ferrari, Ermanno (1)
- Wonderful plants (1)
- World War I (1)
- X-ray analysis (1)
- X. couchianus (1)
- X. hellerii (1)
- XIAP (1)
- XPS (1)
- Xiphophorus (1)
- Xiphophorus fish (1)
- Yersinia (1)
- Yield (1)
- Zebrafish (1)
- Zenith Angle (1)
- \(^{68}\)Ga-Pentixafor (1)
- accumulation (1)
- acetyltransferases (1)
- achaete-scute homolog 1 (1)
- acquired thermotolerance (1)
- acquisition (1)
- action potential (1)
- active transport (1)
- active zone (1)
- acute Graft versus Host Disease (1)
- acute lymphocytic leukaemia (1)
- adaptation models (1)
- adaptive immune system (1)
- adenocarcinoma of the ampulla of Vater (1)
- adenocarcinoma of the lung (1)
- adenomas (1)
- adenoviruses (1)
- adhesion (1)
- adipose (1)
- adipose tissue (1)
- adipose tissue dysfunction (1)
- adipose-derived stem cells (1)
- adjuvant (1)
- administration (1)
- adolescence (1)
- adult attention deficit/hyperactivity disorder (1)
- adults (1)
- aerodynamics (1)
- age factors (1)
- age-related macular degeneration (1)
- aged (1)
- aged 80 and over (1)
- aggressiveness (1)
- agri-environment schemes (1)
- agriculture (1)
- aktuelle Situation (1)
- albumin excretion rate (1)
- alfabetización mediática (1)
- algorithm (1)
- aliphatic compounds (1)
- alkenes (1)
- allergy (1)
- allogeneic hematopoietic stem cell transplantation (1)
- allogeneic stem cell transplantation (1)
- allostatic load (1)
- alpha-galactosidase A (1)
- alternative to animal testing (1)
- alternatives (1)
- amber codon suppression (1)
- amino-acids (1)
- aminoquinolinium salts (1)
- amphotericin B (1)
- amplicon sequencing (1)
- analysis of variance (1)
- anaplastic medulloblastoma (1)
- anastomotic leakage (1)
- anatomical landmark (1)
- anchoring (1)
- anemia (1)
- aneurysm surgery (1)
- angiogenesis (1)
- angiogenic cytokines (1)
- angiography (1)
- animal models (1)
- animal movement (1)
- animals (1)
- anionic dimetalloborylene complexes (1)
- anisotropy energy (1)
- annotation (1)
- ant-mimicking spiders (1)
- antennas (1)
- anterior optic tubercle (1)
- antero-posterior axis (1)
- anthropogenic activities (1)
- anti-tumor effects (1)
- antibacterial activity (1)
- anticipation (1)
- anticipatory planning (1)
- anticoagulants (1)
- antidepressants (1)
- antidiabetic agents (1)
- antiferromagnet (1)
- antimicrobial resistance (1)
- antimycotics (1)
- antioxidants (1)
- antiretroviral therapy (1)
- antitumor immune response (1)
- antiviral immunity (1)
- antiviral treatment (1)
- ants (1)
- anxiety disorders (1)
- anxiety-like behavior (1)
- análisis transnacional (1)
- aphasia (1)
- applied physics (1)
- approach (1)
- aquaporin 4 (1)
- aquaporin-4 antibodies (AQP4-IgG) (1)
- aqueous-solution (1)
- arabidopsis (1)
- arabidopsis-thaliana (1)
- arctic (1)
- army ants (1)
- arousal (1)
- artificial diet (1)
- ascites (1)
- aspergillus fumigatus (1)
- assembly (1)
- assembly chaperone (1)
- assistive technology (1)
- association (1)
- associative memory (1)
- asthma (1)
- astrocytes (1)
- atmospheric chemistry (1)
- atopic-dermatitis (1)
- atrial fibrillation (1)
- attentional bias (1)
- attraction (1)
- audio stimulus (1)
- auditory (1)
- auditory stimulation (1)
- autism (1)
- autism spectrum disorder (1)
- autoantibody (1)
- autoimmunity (1)
- autophagy (1)
- autoradiography (1)
- azidothymidine (1)
- azobenzenes (1)
- bacterial genetics (1)
- bacterial infection (1)
- bed bug (1)
- bee community (1)
- bees (1)
- behavior (1)
- benzoquinone (1)
- beta oscillations (1)
- beta-D-glucan (1)
- beta-blockers (1)
- beta2-adrenoceptor knockout (1)
- beta3 CL 316,243 (1)
- biliary-tract cancer (1)
- binding components (1)
- bio-orthogonal chemistry (1)
- biochemistry (1)
- biocompatibility (1)
- biodiversity assessment (1)
- bioenergetics (1)
- biofuels (1)
- biogenic volatile organic compounds (1)
- bioinformatics (1)
- bioinspired materials (1)
- biolog (1)
- biological mechanism (1)
- bioluminescence (1)
- bioluminescence imaging (1)
- biomarkers Myelomas (1)
- biomechanical test (1)
- biophotonic imaging (1)
- biopsy (1)
- biosensors (1)
- birth cohort (1)
- bis-terpyridyl ligands (1)
- black lipid bilayer (1)
- blastemal (1)
- blood (1)
- blood coagulation (1)
- blood flow (1)
- blood plasma (1)
- blood pressure (1)
- blood pressure monitoring (1)
- body mass index (1)
- body weight (1)
- body weight regulation (1)
- bone imaging (1)
- bone metastases (1)
- boron (1)
- botulinum toxin (1)
- brain computer interface (1)
- brain derived neurotrophic factor (1)
- brain response (1)
- brain swelling (1)
- brain tumor (1)
- brain-computer interface (1)
- brain-computer interface (BCI) (1)
- brain-injury (1)
- break-in parties (1)
- breast cancer subtypes (1)
- breast-cancer (1)
- brefeldin-a (1)
- broodtranslocation (1)
- bug riptortus-pedestris (1)
- bull’s eye plot (1)
- cAMP (1)
- caenorhabditis elegans (1)
- cag pathogenicity island (1)
- calcification (1)
- calcineurin signaling cascade (1)
- calcitonin gene-related peptide (1)
- calcium sensitivity (1)
- calcium signaling (1)
- calorie content (1)
- calyx (1)
- camelina-sativa (1)
- camponotus ants (1)
- campylobacter jejuni infection (1)
- campylobacter-jejuni (1)
- cancer biology (1)
- cancer cells (1)
- cancer chemotherapy (1)
- cancer detection and diagnosis (1)
- cancer risk (1)
- cancer stem cells (1)
- canopy spiders (1)
- capacitance (1)
- carbenes (1)
- cardiac (1)
- cardiac arrest documentation (1)
- cardiac pacing (1)
- cardiopulmonary resuscitation (1)
- cardiorespiratory disease (1)
- cardiovascular (1)
- cardiovascular disease (1)
- cardiovascular outcomes (1)
- care (1)
- carotid arteries (1)
- cascade reactions (1)
- cell biology (1)
- cell compartmentation (1)
- cell cycle and cell division (1)
- cell cycle arrest (1)
- cell death (1)
- cell differentiation (1)
- cell labeling (1)
- cell membranes (1)
- cell motility (1)
- cell proliferation (1)
- cell signalling (1)
- cell staining (1)
- cell vaccines (1)
- cellular imaging (1)
- central complex (1)
- central lung (1)
- central nervous system (1)
- cephalosporin-resistant gram-negative bacteria (1)
- cerebral blood flow (1)
- cervical dystonia (1)
- cesioflammea (1)
- cestodes (1)
- chemokine receptor-4 (1)
- chemotaxis (1)
- child development (1)
- child memory (1)
- childhood asthma (1)
- childhood maltreatment (1)
- chip analyses (1)
- chloroquine (1)
- chorioretinal lesions (1)
- chromatin (1)
- chromism (1)
- chronic myelogenous leukemia (1)
- chronic myeloid leukemia (1)
- chronic obstructive (1)
- chronic periodontitis (1)
- chronic respiratory-diseases (1)
- chronobiology (1)
- circularly-polarized light (1)
- classification (1)
- classification and labeling (1)
- claudin 5 (1)
- climate factors (1)
- climate impact (1)
- clinical (1)
- clinical trial (1)
- clinical-practice (1)
- clip control (1)
- cloning (1)
- closed-loop (1)
- cloud gap filling (1)
- cluster-RCT (1)
- co-adaptive (1)
- coagulation factor XIIa (1)
- coatings (1)
- cochlear nucleus neurons (1)
- coconut cocos-nucifera (1)
- coexistence (1)
- cognition (1)
- cognition development (1)
- cognitive functions (1)
- coherence (1)
- coherence analysis (1)
- coherent light (1)
- colony survival (1)
- color vision (1)
- common factors (1)
- common teal (1)
- community ecology (1)
- community-dwelling (1)
- comparative HRM (1)
- competency based teaching (1)
- complexes (1)
- complication (1)
- composites (1)
- compounds (1)
- computer-assisted (1)
- conditioned response (1)
- conductance (1)
- conductive hearing loss (1)
- cone beam CT (1)
- cones (1)
- confocal laser microscopy (1)
- congenital ocular motor apraxia (1)
- consistent partial least squares (1)
- conspicuous consumption (1)
- contact activation system (1)
- contrast (1)
- conversion (1)
- converting enzyme-inhibition (1)
- coping with challenge (1)
- copper (1)
- corneal equivalent (1)
- corporate restructuring (1)
- correlation function (1)
- correlation properties (1)
- correlative light and electron microscopy (1)
- corticosteroids and cyclophosphamide (1)
- costly (1)
- couplers (1)
- critical discourse analysis (1)
- critical limits (1)
- crop pollination (1)
- cropland vegetation phenology (1)
- cross-species comparison (1)
- crossnational analysis (1)
- cryptogenic stroke (1)
- crystal-structure (1)
- curricula (1)
- currículo de la educación en medios (1)
- currículum (1)
- cuticular transpiration (1)
- cuticular wax (1)
- cutin (1)
- cyclic perylene bisimide (1)
- cyclic test (1)
- cycloid psychoses (1)
- cytokinins (1)
- cytoplasm (1)
- cytoplasmic staining (1)
- cytoskeleton dynamics (1)
- cytosol (1)
- cytostatic (1)
- dRNA-Seq (1)
- damped-oscillator-model of photoperiodic clock (1)
- daratumumab monotherapy (1)
- dark matter (1)
- dark matter detectors (1)
- dark matter experiments (1)
- data mining/methods (1)
- debate (1)
- decision making (1)
- decision support (1)
- deep sea neutrino telescope (1)
- deficient mutant (1)
- dehydration (1)
- delineation (1)
- democracy (1)
- dendric cells (1)
- depreissia decipiens (1)
- depression (1)
- dermal melanocytosis (1)
- desert (1)
- design (1)
- detrusor muscle (1)
- deuterostomes (1)
- deutsche Kreuzzugslyrik (1)
- development (1)
- developmental biology (1)
- developmental delay (1)
- developmental disorders (1)
- devices for energy harvesting (1)
- diabetes (1)
- diabolical points (1)
- diagnosis (1)
- diapause (1)
- diarrhea (1)
- diborenes (1)
- dichroism (1)
- dichthadiigynes (1)
- dicyclohexyl phthalate (1)
- dietary sodium restriction (1)
- diffuse (1)
- dilaboration (1)
- dimerization (1)
- direct anterior approach (1)
- direct stochasticoptical reconstruction microscopy (1)
- discordance (1)
- disease risk-factors (1)
- disease-activity score (1)
- distance running (1)
- distributed control (1)
- disulfide bonds (1)
- dogs (1)
- dopamine transporters (1)
- dopaminergics (1)
- dorsolateral prefrontal cortex (1)
- dosimetry (1)
- dot probe (1)
- draft genome (1)
- dressed states (1)
- drug (1)
- drug adherence (1)
- drug treatment (1)
- drug-eluting beads (1)
- drug-minded protein (1)
- dsRNA binding protein (1)
- dual function (1)
- dual polarimetry (1)
- dunce (1)
- dyes/pigments (1)
- dyspnea (1)
- early diagnosis (1)
- early literacy (1)
- early secretory pathway (1)
- echocardiography (1)
- economic growth (1)
- ecosystem services (1)
- ectotherms (1)
- edema (1)
- educación en medios (1)
- educational tool (1)
- effectiveness (1)
- electric field distribution (1)
- electrocardiography (1)
- electronic and spintronic devices (1)
- ellipsoid (1)
- elliptic PDE (1)
- embryonic stem cells (1)
- emissions (1)
- emotion (1)
- emotional regulation (1)
- emotions (1)
- empagliflozin (1)
- end-state comfort effect (1)
- endemism (1)
- endocrine therapy (1)
- endoplasmic-reticulum (1)
- endosomes (1)
- endosponge (1)
- endothelial cells (1)
- endovascular treatment (1)
- endurance (1)
- energy density (1)
- energy deprivation (1)
- enhanced green fluorescent protein (1)
- enoyl-ACP reductase inhibitors (1)
- enseñanzapor por competencias (1)
- enteric pathogens (1)
- entropy production (1)
- enzyme (1)
- enzyme purification (1)
- enzyme regulation (1)
- enzyme structure (1)
- enzymes (1)
- epidermis (1)
- epigenetic silencing (1)
- epigenetics (1)
- epilepsy (1)
- episches Gedicht (1)
- epithelial-mesenchymal transition (1)
- erythrocytes (1)
- essential tremor (1)
- ethanol (1)
- euchromatin (1)
- european leukemia net (1)
- eutrino physics (1)
- evaluation (1)
- evolutionary consumer psychology (1)
- evolutionary fixation (1)
- exciton coupling (1)
- exciton transfer (1)
- exciton-polariton (1)
- exciton-polariton condensates (1)
- excitons (1)
- excretory-secretory (1)
- executive function training (1)
- exocrine glands (1)
- expectation (1)
- experience (1)
- experimental cerebral malaria (1)
- experimental design (1)
- expert systems (1)
- export (1)
- eye irritation testing (1)
- eyes (1)
- fMRI (1)
- fabry disease (1)
- factor XII (1)
- familial amyloidotic polyneuropathy (1)
- fatal cardiovascular disease (1)
- fatigue (1)
- fatty liver (1)
- fear generalization (1)
- fear response (1)
- female (1)
- female choice (1)
- females (1)
- fentanyl (1)
- ferromagnet (1)
- ferromagnetism (1)
- fetal brain development (1)
- fetal testis (1)
- fibroblast (1)
- fibromyalgia syndrome (1)
- field (1)
- field boundaries (1)
- fine-needle-aspiration (1)
- fine-scale mapping (1)
- finger protein 11 (1)
- fingers (1)
- fish (1)
- fish model (1)
- flagella (1)
- flavonoid (1)
- fluorescence recovery after photobleaching (1)
- fluorescence spectra (1)
- fluorescent dyes (1)
- fluorescent-probes (1)
- fluorophore (1)
- fluorophores (1)
- focal (1)
- follicular T helper cells (1)
- food consumption (1)
- food-cues (1)
- foraging (1)
- force relationship (1)
- forest edges (1)
- forest fragmentation (1)
- forest hedges (1)
- forest specialists (1)
- formación de profesorado (1)
- formation flight (1)
- frontal cortex (1)
- fruit-flies (1)
- fully automatic (1)
- functional magnetic resonance imaging (1)
- functiones (1)
- fungal disease (1)
- fungal host response (1)
- fungal infection (1)
- fungicide (1)
- gait analysis (1)
- galactomannan (1)
- gamma radiation (1)
- gap junction (1)
- gastrointestinal dysfunction (1)
- gastrointestinal tract (1)
- gaze independence (1)
- gefitinib (1)
- gels (1)
- gemcitabine (1)
- gender (1)
- gene expression data (1)
- gene regulation in immune cells (1)
- genes (1)
- genetic dissection (1)
- genetic polymorphisms (1)
- genetics memory (1)
- genome integrity (1)
- genome sequencing (1)
- genome-wide association study (1)
- geographic biases (1)
- geographical variation (1)
- geomorphology (1)
- german multicenter (1)
- germinal center (1)
- germline (1)
- giant intracranial aneurysm (1)
- glands (1)
- glioblastoma (1)
- global dataset (1)
- global reporting initiative (1)
- glucocorticoid receptor (1)
- glucocorticoid replacement therapy (1)
- glucose handling (1)
- glucose lowering agent (1)
- glucose metabolism (1)
- glutamate (1)
- glycation end products (1)
- glycemic control (1)
- glycine (1)
- goutallier (1)
- granules (1)
- ground states (1)
- group 3 (1)
- group refractive index (1)
- growth-factor-receptor (1)
- guality-of-life (1)
- guidelines (1)
- gut microbiota (1)
- gynecologic surgical procedures/methods (1)
- hOCT1 (1)
- habitat use (1)
- hadronic colliders (1)
- halophilic fungus (1)
- hands (1)
- happiness (1)
- hazard perception (1)
- health monitoring (1)
- health risk assessment (1)
- health status (1)
- health status instruments (1)
- health-assessment questionnaire (1)
- heart (1)
- heart disease (1)
- heart failure (1)
- hematological disorders (1)
- hematopoietic SCT (1)
- hematopoietic stem cells (1)
- hemoglobin (1)
- hepatic stellate cells (1)
- hepatocellular carcinoma (1)
- heteromorphic sex chromosomes (1)
- heuristics and biases (1)
- high resolution visualisation (1)
- high-altitude training (1)
- high-intensity interval training (1)
- high-intensity training (1)
- high-osmolarity glycerol (HOG) (1)
- high-risk hematology (1)
- high-risk prostate cancer (1)
- high-throughput (1)
- high-throughput screening (1)
- highly-active antiretroviral therapy (1)
- hip (1)
- hip replacement (1)
- hippocampal neurogenesis (1)
- hippocampus (1)
- histologic diversity (1)
- histology (1)
- histone H3 (1)
- histone acetylation (1)
- histone γH2AX (1)
- histopathology (1)
- historische Situation (1)
- homeostasisIon channels (1)
- homochirality (1)
- honeybee (1)
- hormona therapy (1)
- hormones (1)
- host cells (1)
- hour-glass (1)
- hourglass clock (1)
- human (1)
- human biomarker (1)
- human cell nucleus (1)
- human cholangiocellular carcinoma (1)
- human ectoparasite (1)
- human hematopoiesis (1)
- human intrahepatic cholangiocarcinoma (1)
- human retinal pigment epithelium (1)
- humoral immunity (1)
- hybrid state (1)
- hydnocarpin (1)
- hydrogen bonding (1)
- hydrogenation (1)
- hydrolysis (1)
- hyperekplexia (1)
- hypermethylated DNA (1)
- hypermethylation (1)
- hypersensitivity (1)
- hyperspectral autofluorescence imaging (1)
- hypertension (1)
- hyperthermia (1)
- hypertonic solution (1)
- hypertrophic cardiomyopathy (1)
- hyponatremia (1)
- hypothalamus (1)
- hypoxia-inducible factor 3A (1)
- iNOS (1)
- iberis amara extract (1)
- image data (1)
- image processing (1)
- image quality (1)
- immersion (1)
- immersive classroom (1)
- immersive classroom management (1)
- immune activation (1)
- immune cell recruitment (1)
- immune cells (1)
- immune escape (1)
- immune response (1)
- immune-responses (1)
- immunoglobulin-e (1)
- immunohistochemistry (1)
- immunological reactivity (1)
- immunoreactive neurons (1)
- impulsivity (1)
- in-vitro (1)
- indirect detection (1)
- induce cyclooxygenase-2 expression (1)
- infant faces (1)
- infection control (1)
- infections (1)
- inflammatory bowel disease (1)
- inflammatory diseases (1)
- influence (1)
- influenza virus (1)
- informality (1)
- inherited metabolic disorders (1)
- innexins (1)
- insect flight (1)
- insects (1)
- insertable cardiac monitor (1)
- instructional support (1)
- insulin resistance (1)
- insulin signaling (1)
- insulin tolerance test (1)
- integraed care (1)
- integrins (1)
- intelligent vehicles (1)
- intensification (1)
- intensive glucose control (1)
- interaction partners (1)
- interband cascade laser (1)
- interferon alpha (IFNα) (1)
- interferon alpha signalling (1)
- interferon signaling (1)
- interferon-alpha (1)
- interleukin-1β (1)
- interleukins (1)
- internalization (1)
- interstitial duplications (1)
- intestinal-type adenocarcinoma (1)
- intracellular domain (1)
- intracellular hydrogen-peroxide (1)
- intracellular membranes (1)
- intracellular receptors (1)
- intracellular transport (1)
- intrachromosomal telomeric sequences (1)
- intraoperative (1)
- intraoperative radiotherapy (1)
- intraosseous (1)
- intrasexual competition (1)
- intrathecal application (1)
- invasive aspergillosis (1)
- invasive fungal infections (1)
- invasive meningococcal disease (1)
- invasive vascular interventions (1)
- investigación (1)
- investigación de currículo universitario (1)
- inflammatory response (1)
- iota-toxin (1)
- iron (1)
- irrigated cropland extent (1)
- jasmonates (1)
- jasmonic acid biosynthesis (1)
- judgment (1)
- jump-diffusion processes (1)
- jumping spiders (1)
- junction proteins (1)
- karyotypes (1)
- ketogenic dients (1)
- kidney (1)
- kidney disease (1)
- kinematics (1)
- kinetics (1)
- knee rotator cuff (1)
- knees (1)
- knowledge-based systems (1)
- lamivudine (1)
- land and water management (1)
- land-cover change (1)
- land-use change (1)
- landsat central asia (1)
- landscape compositionv (1)
- laparoscopy/methods (1)
- large-scale assessment (1)
- larval drosophila (1)
- lasers (1)
- late gadolinium enhancement (1)
- late-onset (1)
- leaf beetle (1)
- left ventricular hypertrophy (1)
- leg cramps (1)
- legionary ants (1)
- leukemia inhibitory factor (1)
- life history (1)
- light pulses (1)
- light sources (1)
- light-induced gene expression (1)
- light-matter coupling (1)
- light-trapping (1)
- light–matter interaction (1)
- linguistic character (1)
- linkage (1)
- lipid desaturation (1)
- lithium (1)
- liturgy (1)
- liver metastasis (1)
- lncRNAs (1)
- localization micoscopy (1)
- locked-in syndrome (1)
- locomotion (1)
- locomotor activity (1)
- long ncRNA (1)
- long-term survivors (1)
- low-threshold fibers (1)
- lower body (1)
- luciferase (1)
- lung and intrathoracic tumors (1)
- lungfish (1)
- lutetium-177 (1)
- lux (1)
- luxury brands (1)
- lymph node dissection (1)
- lymph nodes (1)
- lymphocyte differentiation (1)
- lymphoma (1)
- lysosomal storage disease (1)
- mRNA (1)
- machine leaning (1)
- macroecology (1)
- magnetic dopants (1)
- magnetic fields (1)
- magnetic properties and materials (1)
- magnetic resonance spectroscopy (1)
- magnetic susceptibility (1)
- magnetism (1)
- magnetized sphere/cylinder (1)
- main-group chemistry (1)
- male rats (1)
- mammography (1)
- managing big data (1)
- mandible (1)
- marcador (1)
- marrow stromal cells (1)
- mass index (1)
- maternal behavior (1)
- mathematical model (1)
- mathematical modeling (1)
- matrix metalloproteinases (1)
- maturation (1)
- mechanical energy (1)
- mechanical thrombectomy (1)
- mechanism (1)
- mechanisms (1)
- media education (1)
- media literacy (1)
- medical collateral ligament (1)
- medical rehabilitation (1)
- meiotic ‘superring’ (1)
- melanoma (1)
- melanoma therapy (1)
- meliponines (1)
- membrane biophysics (1)
- membrane proteins (1)
- memory formation (1)
- men (1)
- meningococcal disease (1)
- merocyanines (1)
- mesenchymal stem-cells (1)
- messenger RNA (1)
- metabolic risk (1)
- metabolic syndrome (1)
- metacognitive prompting (1)
- metal borylene complexes (1)
- metal caponyls (1)
- metal cluster (1)
- metal-cluster hybrid systems (1)
- metal-to-ligand charge transfer (MLCT) (1)
- metallaboranes (1)
- metamorphosis (1)
- methylation (1)
- methylphenidate (1)
- miRNA (1)
- miRNA expression (1)
- miRNAs (1)
- micro-level analysis (1)
- microRNAs (1)
- microbiota (1)
- microcavity exciton polaritons (1)
- microcrystalline zinc hydroxyapatiteimpact (1)
- microglomeruli (1)
- microlaser (1)
- micronuclei (1)
- microprocessor (1)
- microscopy (1)
- microvascular endothelial cells (1)
- microwave radiation (1)
- middle Aged (1)
- middle ear (1)
- middle ear implant (1)
- migration (1)
- minimally conscious state (1)
- minimally important difference (1)
- minimally-invasive (1)
- minimum (1)
- mismatch (1)
- mitogen activated protein kinase (MAPK) (1)
- mitosis (1)
- mixed hearing loss (1)
- mobiler Auskunftsdienst (1)
- model (1)
- model following (1)
- modeling (1)
- modis (1)
- modulated arc therapy (1)
- modulation spectroscopy (1)
- molar tooth sign (1)
- molecular biology (1)
- molecular dynamics (1)
- molecular mechanics (1)
- molecular response in cml (1)
- molecular-structure (1)
- monoclonial gammopathy (1)
- monocyte subset (1)
- moral judgment (1)
- morphotypes (1)
- moths (1)
- motion (1)
- motor axonal neuropathy (1)
- motor control (1)
- motor development (1)
- mouse model (1)
- mouse models DNA damage (1)
- mouse-brain (1)
- mucosa (1)
- mucosal inflammation (1)
- multi-drug resistance (1)
- multifaceted approaches (1)
- multifocal choroiditis (1)
- multihit targeting (1)
- multimetallic complexes (1)
- multimodal (1)
- multimorbidity (1)
- multiple myeloma Lesions (1)
- multiple sequence alignments (1)
- multiple sklerosis (1)
- music background (1)
- musical training (1)
- mutation detection (1)
- myeloma cells (1)
- myocardial infarction (1)
- myocardial lipid content (1)
- myocardial fibrosis (1)
- myocarditis (1)
- myocardium (1)
- myocyte (1)
- n-hexyl phthalate (1)
- nab-paclitaxel (1)
- naive T cells (1)
- nano LDH (1)
- nanoagent (1)
- nanographene (1)
- nanoparticle albumin-bound paclitaxel (1)
- nanophysics (1)
- nanotube (1)
- natural genetic variation (1)
- natural products (1)
- neck circumference (1)
- needle surface waxes (1)
- neoadjuvant (1)
- neovascularization, physiologic (1)
- nerve fibers (1)
- nerve ultrasonography (1)
- nervous-system (1)
- nervous-sytem (1)
- neural circuits (1)
- neural stem-cells (1)
- neuroendocrine tumor (1)
- neuroendocrine tumor (NET) (1)
- neurogenic locus notch homolog (1)
- neuroimaging (1)
- neuroimmunology (1)
- neuromyelitis optica (1)
- neuromyelitis optica spectrum disorders (NMOSD) (1)
- neuropathy (1)
- neuropeptides (1)
- neuroplasticity (1)
- neutralino (1)
- neutralizing antibody (1)
- neutrino detectors (1)
- neutrino emission (1)
- neutrino mass hierarchy (1)
- neutrino telescope (1)
- neutrophil (1)
- neutrophils (1)
- niche dynamics (1)
- nicotinic acetylcholine receptors (1)
- nitric oxide (1)
- nitrites (1)
- no-flow fraction (1)
- nocebo hyperalgesia (1)
- nodes of Ranvier (1)
- noise and multimode dynamics (1)
- non-crop habitats (1)
- non-invasive biomarkers (1)
- non-motor features (1)
- nonadiabatic dynamics (1)
- nonlinear dynamics (1)
- nuclear power (1)
- nuclear staining (1)
- nucleation elongation (1)
- nucleation-elongation model (1)
- nucleoside transporter (1)
- nurses (1)
- obsessive-compulsive disorder (1)
- octopamine (1)
- off-targets (1)
- oil storage (1)
- older people (1)
- olfaction (1)
- olfactory receptor (1)
- oncology (1)
- oncolytic virus therapy (1)
- one-electron oxidation (1)
- online adaption (1)
- online monitoring system (1)
- online tool (1)
- onset craniopharyngioma (1)
- ontologies (1)
- open surgical repair (1)
- opponent processes (1)
- optic neuritis (1)
- optical coherence tomography (1)
- optical response (1)
- optics and photonics (1)
- optimal control (1)
- optimal control theory (1)
- optoelectronics (1)
- ordinal categorical indicators (1)
- organic (1)
- orthotopic xenograft (1)
- osteoporosis (1)
- otitis media (1)
- outer membrane protein (1)
- outer retinal tubulation (1)
- output elasticities (1)
- over-the-counter drugs (1)
- overload (1)
- oxygen-metabolism (1)
- oxytocin (1)
- p27(KIP1) (1)
- pCa (1)
- pICln (1)
- palladium (1)
- pancreatobiliary type (1)
- panobinostat (1)
- parainfluenza virus (1)
- parasite biology (1)
- parasitic cell cycles (1)
- parasitic diseases (1)
- parasitic life cycles (1)
- parasitology (1)
- parental origin (1)
- partial integro-differential Fokker-Planck Equation (1)
- pathogens (1)
- pathway analysis (1)
- patient education (1)
- pedagogy (1)
- pedagogía (1)
- pediatric brain tumor (1)
- peer-to-peer Auskunftsdienst (1)
- pelvic organ prolapse/surgery (1)
- perforator (1)
- performance (1)
- performance monitoring (1)
- performance parameters (1)
- periodontal health (1)
- peripheral artery occlusive disease (1)
- peripheral injury (1)
- peripheral nerve (1)
- peripheral neuropathy (1)
- peripheral vision (1)
- peripheral-blood (1)
- perpetual, never-ending narrative (1)
- perylene bisimide hydrogels (1)
- phage display (1)
- phakomatosis pigmentovascularis (1)
- pharmacogenetics (1)
- phase transitions and critical phenomena (1)
- phasematching (1)
- phenology (1)
- phenomenology (1)
- phenotype (1)
- phenotypic microarray (1)
- phonological awareness (1)
- phonological training (1)
- phosphocholine (1)
- phosphoproteomics (1)
- photoactivation (1)
- photoinduced electron transfer (1)
- photon bunching (1)
- photon lasing (1)
- photon statistics (1)
- photonics (1)
- photoperiodic time mesurement (1)
- photoreceptors (1)
- phototransduction (1)
- phyllosphere (1)
- phylotypic (1)
- physical therapy modalities (1)
- physicians (1)
- physiological traits (1)
- phytoprostanes (1)
- piRNA (1)
- pig model (1)
- pigment (1)
- pinned orbital moments (1)
- pitcher-plant mosquito (1)
- pituitary adenomas (1)
- pituitary gland (1)
- placebo hypoalgesia (1)
- planarian (1)
- planning variability (1)
- plans (1)
- plant cuticle (1)
- plant symbioses (1)
- plaque (1)
- plaque formation (1)
- plasma extravasation (1)
- plasmid copy number (1)
- plasminogen (1)
- plasticity (1)
- platelet dysfunction (1)
- platyhelminthes (1)
- polarimetric decomposition (1)
- polarition condensate (1)
- polariton laser (1)
- polarity effects (1)
- polarization vision (1)
- pollution functions (1)
- polychoric correlation (1)
- polycyclic aromatic hydrocarbons (1)
- polymer characterization (1)
- polymer synthesis (1)
- polyomavirus (1)
- polypyridyl complexes (1)
- polysensitization (1)
- popliteal aneurysm (1)
- positive lymph node (1)
- positron emission tomography/computed tomography (1)
- post-processing (1)
- post-traumatic stress disorder (1)
- postoperative complications/epidemiology (1)
- postpartum (1)
- posttranslational modifications (1)
- precedes multiple-myeloma (1)
- pregnancy (1)
- pregnancy gingivitis (1)
- preprocessing (1)
- preschool children (1)
- presence (1)
- preservice teacher education (1)
- prevention (1)
- prey selection (1)
- primary sclerosing cholangitis (1)
- probiotic lozenges (1)
- process mining (1)
- progenitors (1)
- prognosis (1)
- proliferating cell nuclear antigen (PCNA) (1)
- promoter affinity (1)
- propensity score matching (1)
- prophage (1)
- prospective study (1)
- prostate-cancer (1)
- protein engineering (1)
- protein phosphorylation (1)
- protein synthesis (1)
- protein translocation (1)
- protein ubiquitination (1)
- proteomes (1)
- proteomic analysis (1)
- proteomics (1)
- protocadherin gamma cluster (1)
- protophormia terraenovae (1)
- proximal method (1)
- proximal methods (1)
- pseudocarcinomatous hyperplasia (1)
- psoriasis (1)
- psychological placebo intervention (1)
- pulmonary aspergillosis (1)
- pulmonary disease (1)
- pulmonary imaging (1)
- pulmonary toxicity (1)
- punishment (1)
- pustular exanthema (1)
- pyramidal neurons (1)
- quadcopter (1)
- quality-control (1)
- quantitative assessments (1)
- quantum billiard (1)
- quantum chemical analysis (1)
- quantum dot laser (1)
- queens (1)
- quinine (1)
- quorum sensing (QS) (1)
- radar (1)
- radiation sensitivity (1)
- radiation-therapy (1)
- radioactive waste (1)
- radiotherapy (1)
- rainforest (1)
- random forest models (1)
- randomized controlled clinical trial (1)
- randomized trial (1)
- ranscription factors (1)
- rare SNP (1)
- rare diseases (1)
- rats (1)
- reaction mechanism (1)
- reaction mechanisms (1)
- reactive electrophilic species (1)
- reactive oxygen species (1)
- real-time PCR (1)
- receptor (1)
- receptor tyrosine kinase (1)
- recombinant proteins (1)
- recombinat-human-erythropoietin (1)
- reconsolidation (1)
- reconstruction (1)
- reconstructive surgical procedures/methods (1)
- recurrence (1)
- reflection (1)
- regressive (1)
- regulatory T cells (1)
- relapsed (1)
- relapsed and refractory (1)
- relaxation (1)
- relief (1)
- renal scintigraphy (1)
- renal system (1)
- renoprotection (1)
- repair and replication (1)
- repeated shuttle sprints (1)
- replication (1)
- reported outcomes (1)
- reporter genes (1)
- reproducible science (1)
- reproductive and developmental toxicity (1)
- reproductive character displacement (1)
- reproductive diapause (1)
- research (1)
- resolution limit (1)
- resource availability (1)
- respiratory syncytial virus (1)
- response inhibition (1)
- retinal dystrophies (1)
- retinal neuro-axonal damage (1)
- retro-cue (1)
- retrospective Studies (1)
- return to work (1)
- reverse transcriptase (1)
- reward (1)
- rheumatology (1)
- rhinitis (1)
- rhythmic components (1)
- ribavirin serum levels (1)
- ribonuclease H (1)
- ribosome (1)
- rice (1)
- right inferior frontalgyrus (1)
- risk factor (1)
- risk-assesment (1)
- roaming reference (1)
- robustness (1)
- romantisches Gedicht (1)
- root growth (1)
- rostral-migratory-stream (1)
- rotator cuff (1)
- rotors (1)
- roving reference (1)
- safety (1)
- salvage radiotherapy (1)
- sampling bias (1)
- sampling method (1)
- sarcoidosis (1)
- sarcopenia (1)
- sarcopterygian fish (1)
- scalable quadcopter (1)
- sclerostin (1)
- second hit (1)
- secondary CNV (1)
- secondary lung tumors (1)
- seedlings (1)
- seeds (1)
- segmentation (1)
- selective accessibility (1)
- self-assembly (1)
- self-management (1)
- self-regulated learning (1)
- self-renewal (1)
- semantic technologies (1)
- semi-natural habitats (1)
- semismooth Newton method (1)
- sensory cues (1)
- sensory perception (1)
- sequencing protocol (1)
- serial RNA interactome capture (1)
- service infrastructure (1)
- settlement expansion (1)
- setup verification (1)
- sex pheromone (1)
- sexual development (1)
- shock response (1)
- short Synacthen test (1)
- short-term memory (1)
- short-term methylphenidate brain (1)
- shoulder surgery (1)
- sialic acids (1)
- side effects (1)
- side-peak emission (1)
- signal peptides (1)
- signal transduction (1)
- signaling pathway (1)
- signalling pathways (1)
- silaboration (1)
- silybin (1)
- simulation system (1)
- single-molecule biophysics (1)
- skeleton (1)
- skin anatomy (1)
- skin blood flow (1)
- skin cancer (1)
- skin conductance (1)
- skin diseases (1)
- skin equivalents (1)
- skin physiology (1)
- skinned fibers (1)
- sky-compass orientation (1)
- sleep (1)
- slope deposits (1)
- small RNA-sequencing (1)
- small cell lung cancer (1)
- small interfering RNAs (1)
- snRNPs (1)
- social experience (1)
- sodium channel (1)
- sodium uptake (1)
- software (1)
- solubility (1)
- soluble guanylate cyclase (1)
- solvents (1)
- somatostatin receptor (1)
- sorafenib (1)
- speciation (1)
- species distribution model (1)
- species diversification (1)
- specific phobia (1)
- speckle tracking imaging (1)
- spectral characterization (1)
- spectral karyotyping (1)
- spectral-domain optical coherence tomography (1)
- spectroscopy (1)
- speeches (1)
- speed (1)
- spillover (1)
- spin distribution (1)
- spin response (1)
- spine radiosurgery (1)
- spiroborates (1)
- sports technology (1)
- stage renal-disease (1)
- stalking predators (1)
- standard semiconductor laser (1)
- standards (1)
- static mixer (1)
- static test (1)
- statistical data (1)
- stem cell transplantation (1)
- stent implantation (1)
- sterol pathway (1)
- stress markers (1)
- stress signaling cascade (1)
- stressful life events (1)
- stroke (1)
- stroke prevention (1)
- stroke rehabilitation (1)
- structural equation models (1)
- structure (1)
- structured illumination microscopy (1)
- student simulation (1)
- subcutaneous adipose-tissue (1)
- subgingival (1)
- substantia nigra (1)
- subthalamic nucleus (1)
- sun (1)
- super-resolution imaging (1)
- super-resolution microscopy (1)
- superconductors (1)
- supercurrent (1)
- superficial peroneal nerve (1)
- superradiant pulse emission (1)
- supersymmetry (1)
- support vector machines (1)
- suppression (1)
- supramolecular polymerization (1)
- sural nerve (1)
- surgery (1)
- surgical Mesh (1)
- surgical aneurysm treatment (1)
- survival (1)
- susceptibility (1)
- sustainability reporting (1)
- sustained fear (1)
- swim test (1)
- swimming (1)
- synaptic connections (1)
- synaptic inhibition (1)
- synaptic plasticity (1)
- synaptic vesicles (1)
- synapticplasticity (1)
- syndrome (1)
- synthesis process (1)
- systemic immunosuppression (1)
- systemic inflammatory response syndrome (1)
- systemic sclerosis (1)
- targeted re-sequencing (1)
- targets (1)
- taxonomic biases (1)
- taxonomy (1)
- team sport (1)
- teeth (1)
- telomere length (1)
- telomeres (1)
- terminal alkynes (1)
- terrorist attack, Paris, 13th November 2015 (1)
- testosterone (1)
- testosterone production (1)
- tetrametallaborides (1)
- tetraorganoborate salt (1)
- therapy (1)
- thermal adaptation (1)
- thermoregulation (1)
- thermotolerance (1)
- think-aloud data (1)
- thrombopoiesis (1)
- thrombus formation (1)
- thymectomy (1)
- tibial fracture fixation (1)
- tibial head fracture (1)
- time resolved spectroscopy (1)
- time series (1)
- time series analysis (1)
- time-resolved photoelectron spectroscopy (1)
- to-height ratio (1)
- tolerability (1)
- tooth eruption (1)
- torque (1)
- total electric field (1)
- trachea (1)
- tracking (1)
- traffic (1)
- trafficking (1)
- training (1)
- training adaptation (1)
- training load (1)
- trans-splicing (1)
- transarterial chemoembolization (1)
- transcranial direct current stimulation (1)
- transcriptional profiling (1)
- transcriptome (1)
- transcriptome analysis (1)
- transfection (1)
- transferability (1)
- transient absorption (1)
- transition charge (1)
- transition density (1)
- transition dipole moment (1)
- transition temperature (1)
- translation (1)
- translational panic model (1)
- transperineal ultrasound (1)
- transporter protein associated with antigen processing-1 (TAP1) (1)
- transporters (1)
- transposable elements (1)
- treatment (1)
- treatment guidelines (1)
- tremor (1)
- tribes (1)
- triceps brachii (1)
- triglycerides (1)
- trimetallaborides (1)
- trisomy 21 (1)
- triterpenoids (1)
- tropical ecology (1)
- troponin T (1)
- trypanosoma brucei gambiense (1)
- tryptophan (1)
- tumor associated macrophages (1)
- tumor cell (1)
- tumor growth (1)
- tumor size (1)
- tundra (1)
- two-dimensional materials (1)
- two-dimensional nanostructures (1)
- tympanic membrane (1)
- type 2 diabetes (1)
- types of government (1)
- tyrosine kinase inhibitors (1)
- ubiquitin (1)
- ultimatum game (1)
- ultrasound (1)
- ultrastructure (1)
- ultraviolet light (1)
- undetermined significance (1)
- unfolded protein response (1)
- unmanned aerial vehicle (1)
- unnatural amino acid (1)
- unresponsive wakefulness syndrome (1)
- unstructured data (1)
- unstrukturierte Daten (1)
- upper body (1)
- upramolecular polymerization process (1)
- upstream regulator (1)
- urban growth modelling (1)
- urbanization (1)
- urinary incontinence/surgery (1)
- user-centered design (1)
- uterine prolapse/surgery (1)
- uveal melanoma (1)
- vagina/surgery (1)
- valence (1)
- validation (1)
- variant of unknown significance (1)
- vascular permeability (1)
- vascular type (1)
- vascularization (1)
- vasculitis (1)
- vasoconstriction (1)
- vegetation dynamics (1)
- vegetative state (1)
- vehicle dynamics (1)
- velocity (1)
- vertebral metastases (1)
- vertebrates (1)
- vesicles (1)
- vessel patency (1)
- vibration (1)
- vibroplasty (1)
- viral carcinogenesis (1)
- viral load (1)
- viral replication (1)
- viral shedding (1)
- virtual agent interaction (1)
- virtual reality (1)
- virtual reality training (1)
- visceral adiposity (1)
- viscosity (1)
- visual acuity (1)
- visual evoked potentials (1)
- visual orientation (1)
- visual working memory (1)
- vitamin D (1)
- volatile (1)
- wasp-mimicking (1)
- water (1)
- wave functions (1)
- wearable technologies (1)
- weight drop (1)
- weight gain (1)
- weight of evidence (1)
- whole genome duplications (1)
- whole genome sequencing (1)
- whole-body electromyostimulation (1)
- whole-genome shotgun sequencing (1)
- wild plant pollination (1)
- withdrawal (1)
- words (1)
- work ability (1)
- work-related medical rehabilitation (1)
- working memory (1)
- wyeomyia smithii (1)
- xenopus oocytes (1)
- µ-Opioid receptor (1)
- π–π Stacking (1)
Institute
- Theodor-Boveri-Institut für Biowissenschaften (88)
- Medizinische Klinik und Poliklinik II (35)
- Neurologische Klinik und Poliklinik (31)
- Institut für Psychologie (27)
- Physikalisches Institut (27)
- Medizinische Klinik und Poliklinik I (25)
- Julius-von-Sachs-Institut für Biowissenschaften (22)
- Rudolf-Virchow-Zentrum (22)
- Medizinische Fakultät (19)
- Klinik und Poliklinik für Psychiatrie, Psychosomatik und Psychotherapie (18)
Sonstige beteiligte Institutionen
Reconstructing and understanding the Human Physiome virtually is a complex mathematical problem, and a highly demanding computational challenge. Mathematical models spanning from the molecular level through to whole populations of individuals must be integrated, then personalized. This requires interoperability with multiple disparate and geographically separated data sources, and myriad computational software tools. Extracting and producing knowledge from such sources, even when the databases and software are readily available, is a challenging task. Despite the difficulties, researchers must frequently perform these tasks so that available knowledge can be continually integrated into the common framework required to realize the Human Physiome. Software and infrastructures that support the communities that generate these, together with their underlying standards to format, describe and interlink the corresponding data and computer models, are pivotal to the Human Physiome being realized. They provide the foundations for integrating, exchanging and re-using data and models efficiently, and correctly, while also supporting the dissemination of growing knowledge in these forms. In this paper, we explore the standards, software tooling, repositories and infrastructures that support this work, and detail what makes them vital to realizing the Human Physiome.
Entropy production in industrial economies involves heat currents, driven by gradients of temperature, and particle currents, driven by specific external forces and gradients of temperature and chemical potentials. Pollution functions are constructed for the associated emissions. They reduce the output elasticities of the production factors capital, labor, and energy in the growth equation of the capital-labor-energy-creativity model, when the emissions approach their critical limits. These are drawn by, e.g., health hazards or threats to ecological and climate stability. By definition, the limits oblige the economic actors to dedicate shares of the available production factors to emission mitigation, or to adjustments to the emission-induced changes in the biosphere. Since these shares are missing for the production of the quantity of goods and services that would be available to consumers and investors without emission mitigation, the “conventional” output of the economy shrinks. The resulting losses of conventional output are estimated for two classes of scenarios: (1) energy conservation; and (2) nuclear exit and subsidies to photovoltaics. The data of the scenarios refer to Germany in the 1980s and after 11 March 2011. For the energy-conservation scenarios, a method of computing the reduction of output elasticities by emission abatement is proposed.
Otitis media (OM) is a common pediatric disease for which systemic antibiotics are often prescribed. While local treatment would avoid the systemic treatment side-effects, the tympanic membrane (TM) represents an impenetrable barrier unless surgically breached. We hypothesized that the TM might harbor innate biological mechanisms that could mediate trans-TM transport. We used two M13-bacteriophage display biopanning strategies to search for mediators of trans-TM transport. First, aliquots of linear phage library displaying 10\(^{10th}\) 12mer peptides were applied on the TM of rats with active bacterial OM. The middle ear (ME) contents were then harvested, amplified and the preparation re-applied for additional rounds. Second, the same naïve library was sequentially screened for phage exhibiting TM binding, internalization and then transit. Results revealed a novel set of peptides that transit across the TM to the ME in a time and temperature dependent manner. The peptides with highest transport capacities shared sequence similarities. Historically, the TM was viewed as an impermeable barrier. However, our studies reveal that it is possible to translocate peptide-linked small particles across the TM. This is the first comprehensive biopanning for the isolation of TM transiting peptidic ligands. The identified mechanism offers a new drug delivery platform into the ME.
Background
Ribavirin blood levels vary considerably between patients with standard weight-based dosing. Their impact on sustained virological response (SVR) with pegylated interferon and ribavirin is controversial, but has mostly been studied before the IL28b gene polymorphism as a possible confounder was discovered.
Methods
The impact of serum ribavirin trough levels at week 4, at the end of treatment and of mean levels across the entire antiviral treatment with pegylated interferon and ribavirin on relapse, SVR rates and anemia was retrospectively studied by univariate and multivariable logistic regression analyses in 214 patients with HCV genotype 1–4 infection, including 88 patients with available IL28b genotyping.
Results
Mean ribavirin levels varied between 0.68–5.65 mg/l and significantly differed between patients with or without SVR. By multivariable regression including age, sex, HCV viral load, HCV genotype, liver fibrosis stage, prior treatments, immunosuppression and IL28b genotype, ribavirin levels consistently displayed significant influence on SVR and relapse without indication for a specific importance of higher concentrations early or late in the treatment course. Although hemoglobin decline was on average more pronounced in patients with higher ribavirin levels, hemoglobin remained relatively stable in a significant proportion of these, indicating that ribavirin levels alone are insufficient to predict anemia.
Conclusion
While data are scarce to draw conclusions applicable for modern DAA therapies, these results support ribavirin treatment based on serum levels instead of purely weight-based dosing in combination with pegylated interferon.
One of the most intricate issues of nuclear power is the long-term safety of repositories for radioactive waste. These repositories can have an impact on future generations for a period of time orders of magnitude longer than any known civilization. Several countries have considered copper as an outer corrosion barrier for canisters containing spent nuclear fuel. Among the many processes that must be considered in the safety assessments, radiation induced processes constitute a key-component. Here we show that copper metal immersed in water uptakes considerable amounts of hydrogen when exposed to γ-radiation. Additionally we show that the amount of hydrogen absorbed by copper depends on the total dose of radiation. At a dose of 69 kGy the uptake of hydrogen by metallic copper is 7 orders of magnitude higher than when the absorption is driven by H\(_{2}\)(g) at a pressure of 1 atm in a non-irradiated dry system. Moreover, irradiation of copper in water causes corrosion of the metal and the formation of a variety of surface cavities, nanoparticle deposits, and islands of needle-shaped crystals. Hence, radiation enhanced uptake of hydrogen by spent nuclear fuel encapsulating materials should be taken into account in the safety assessments of nuclear waste repositories.
Background
The current notion that cortico-striato-thalamo-cortical circuits are involved in the pathophysiology of obsessive-compulsive disorder (OCD) has instigated the search for the most suitable target for deep brain stimulation (DBS). However, despite extensive research, uncertainty about the ideal target remains with many structures being underexplored. The aim of this report is to address a new target for DBS, the medial dorsal (MD) and the ventral anterior (VA) nucleus of the thalamus, which has thus far received little attention in the treatment of OCD.
Methods
In this retrospective trial, four patients (three female, one male) aged 31–48 years, suffering from therapy-refractory OCD underwent high-frequency DBS of the MD and VA. In two patients (de novo group) the thalamus was chosen as a primary target for DBS, whereas in two patients (rescue DBS group) lead implantation was performed in a rescue DBS attempt following unsuccessful primary stimulation.
Results
Continuous thalamic stimulation yielded no significant improvement in OCD symptom severity. Over the course of thalamic DBS symptoms improved in only one patient who showed “partial response” on the Yale-Brown Obsessive Compulsive (Y-BOCS) Scale. Beck Depression Inventory scores dropped by around 46% in the de novo group; anxiety symptoms improved by up to 34%. In the de novo DBS group no effect of DBS on anxiety and mood was observable.
Conclusion
MD/VA-DBS yielded no adequate alleviation of therapy-refractory OCD, the overall strategy in targeting MD/VA as described in this paper can thus not be recommended in DBS for OCD. The magnocellular portion of MD (MDMC), however, might prove a promising target in the treatment of mood related and anxiety disorders.
Background
We undertook investigations in response to an invasive meningococcal disease (IMD) outbreak in men who have sex with men (MSM) in Berlin 2012–2013 to better understand meningococcal transmission and IMD risk in MSM.
Methods
We retrospectively searched for further IMD cases in MSM in Germany through local health departments and undertook exploratory interviews. We performed antigen sequence typing, characterized fHbp and aniA genes of strains with the outbreak finetype and reviewed epidemiologically or spatiotemporally linked cases from 2002–2014.
Results
Among the 148 IMD-cases notified from 01.01.2012–30.09.2013 in 18–59 year-old men we identified 13 MSM in 6 federal states: 11 serogroup C (MenC, all finetype C:P1.5–1,10–8:F3-6), 2 MenB. Interviews with 7 MSM revealed frequent meeting of multiple partners online or via mobile apps and illicit drug use as potential risk factors. MenC incidence was 13-fold higher in MSM than non-MSM. MenC isolates from 9/11 MSM had a novel fHbp allele 766. All C:P1.5–1,10–8:F3-6 strains from MSM versus 16/23 from non-MSM had intact aniA genes (p = 0.04). Although definitive evidence for transmission among MSM in epidemiological or spatiotemporal clusters in 2002–2014 was lacking, clusters were more frequent in men aged 20–49 years. Molecular analysis of C:P1.5–1,10–8:F3-6 strains revealed cases with intact aniA since 2007, mainly associated with fHbp361, fHbp766 and fHbp813, all involving one or more MSM.
Conclusions
MenC incidence was elevated in MSM during the study period. Multiple casual sexual contacts and illicit drug use were common in affected MSM. In all strains from MSM we detected an intact aniA gene coding for a nitrite reductase, which permits survival in microanaerobic environments and could play a role in meningococcal transmission in MSM through urogenital colonization. Furthermore, meningococcal transmission among MSM may be sustained over large areas and thus require modified spatiotemporal scanning algorithms for timely detection and control.
We identified the dsRNA binding protein RbdB as an essential component in miRNA processing in Dictyostelium discoideum. RbdB is a nuclear protein that accumulates, together with Dicer B, in nucleolar foci reminiscent of plant dicing bodies. Disruption of rbdB results in loss of miRNAs and accumulation of primary miRNAs. The phenotype can be rescued by ectopic expression of RbdB thus allowing for a detailed analysis of domain function. The lack of cytoplasmic dsRBD proteins involved in miRNA processing, suggests that both processing steps take place in the nucleus thus resembling the plant pathway. However, we also find features e.g. in the domain structure of Dicer which suggest similarities to animals. Reduction of miRNAs in the rbdB- strain and their increase in the Argonaute A knock out allowed the definition of new miRNAs one of which appears to belong to a new non-canonical class.
We compared outcomes from a single-arm study of blinatumomab in adult patients with B-precursor Ph-negative relapsed/refractory acute lymphoblastic leukemia (R/R ALL) with a historical data set from Europe and the United States. Estimates of complete remission (CR) and overall survival (OS) were weighted by the frequency distribution of prognostic factors in the blinatumomab trial. Outcomes were also compared between the trial and historical data using propensity score methods. The historical cohort included 694 patients with CR data and 1112 patients with OS data compared with 189 patients with CR and survival data in the blinatumomab trial. The weighted analysis revealed a CR rate of 24% (95% CI: 20–27%) and a median OS of 3.3 months (95% CI: 2.8–3.6) in the historical cohort compared with a CR/CRh rate of 43% (95% CI: 36–50%) and a median OS of 6.1 months (95% CI: 4.2–7.5) in the blinatumomab trial. Propensity score analysis estimated increased odds of CR/CRh (OR=2.68, 95% CI: 1.67–4.31) and improved OS (HR=0.536, 95% CI: 0.394–0.730) with blinatumomab. The analysis demonstrates the application of different study designs and statistical methods to compare novel therapies for R/R ALL with historical data.
Synapsin is an evolutionarily conserved presynaptic phosphoprotein. It is encoded by only one gene in the Drosophila genome and is expressed throughout the nervous system. It regulates the balance between reserve and releasable vesicles, is required to maintain transmission upon heavy demand, and is essential for proper memory function at the behavioral level. Task-relevant sensorimotor functions, however, remain intact in the absence of Synapsin. Using an odor-sugar reward associative learning paradigm in larval Drosophila, we show that memory scores in mutants lacking Synapsin (syn\(^{97}\)) are lower than in wild-type animals only when more salient, higher concentrations of odor or of the sugar reward are used. Furthermore, we show that Synapsin is selectively required for larval short-term memory. Thus, without Synapsin Drosophila larvae can learn and remember, but Synapsin is required to form memories that match in strength to event salience-in particular to a high saliency of odors, of rewards, or the salient recency of an event. We further show that the residual memory scores upon a lack of Synapsin are not further decreased by an additional lack of the Sap47 protein. In combination with mass spectrometry data showing an up-regulated phosphorylation of Synapsin in the larval nervous system upon a lack of Sap47, this is suggestive of a functional interdependence of Synapsin and Sap47.
Attention-deficit/hyperactivity disorder (ADHD) is a highly heritable childhood-onset neuropsychiatric condition, often persisting into adulthood. The genetic architecture of ADHD, particularly in adults, is largely unknown. We performed an exome-wide scan of adult ADHD using the Illumina Human Exome Bead Chip, which interrogates over 250 000 common and rare variants. Participants were recruited by the International Multicenter persistent ADHD CollaboraTion (IMpACT). Statistical analyses were divided into 3 steps: (1) gene-level analysis of rare variants (minor allele frequency (MAF)<1%); (2) single marker association tests of common variants (MAF⩾1%), with replication of the top signals; and (3) pathway analyses. In total, 9365 individuals (1846 cases and 7519 controls) were examined. Replication of the most associated common variants was attempted in 9847 individuals (2077 cases and 7770 controls) using fixed-effects inverse variance meta-analysis. With a Bonferroni-corrected significance level of 1.82E−06, our analyses of rare coding variants revealed four study-wide significant loci: 6q22.1 locus (P=4.46E−08), where NT5DC1 and COL10A1 reside; the SEC23IP locus (P=6.47E−07); the PSD locus (P=7.58E−08) and ZCCHC4 locus (P=1.79E−06). No genome-wide significant association was observed among the common variants. The strongest signal was noted at rs9325032 in PPP2R2B (odds ratio=0.81, P=1.61E−05). Taken together, our data add to the growing evidence of general signal transduction molecules (NT5DC1, PSD, SEC23IP and ZCCHC4) having an important role in the etiology of ADHD. Although the biological implications of these findings need to be further explored, they highlight the possible role of cellular communication as a potential core component in the development of both adult and childhood forms of ADHD.
Assigning functions to uncultivated environmental microorganisms continues to be a challenging endeavour. Here, we present a new microscopy protocol for fluorescence in situ hybridisation-correlative light and electron microscopy (FISH-CLEM) that enabled, to our knowledge for the first time, the identification of single cells within their complex microenvironment at electron microscopy resolution. Members of the candidate phylum Poribacteria, common and uncultivated symbionts of marine sponges, were used towards this goal. Cellular 3D reconstructions revealed bipolar, spherical granules of low electron density, which likely represent carbon reserves. Poribacterial activity profiles were retrieved from prokaryotic enriched sponge metatranscriptomes using simulation-based optimised mapping. We observed high transcriptional activity for proteins related to bacterial microcompartments (BMC) and we resolved their subcellular localisation by combining FISH-CLEM with immunohistochemistry (IHC) on ultra-thin sponge tissue sections. In terms of functional relevance, we propose that the BMC-A region may be involved in 1,2-propanediol degradation. The FISH-IHC-CLEM approach was proven an effective toolkit to combine -omics approaches with functional studies and it should be widely applicable in environmental microbiology.
Neuromelanin is a complex polymer pigment found primarily in the dopaminergic neurons of human substantia nigra. Neuromelanin pigment is stored in granules including a protein matrix and lipid droplets. Neuromelanin granules are yet only partially characterised regarding their structure and function. To clarify the exact function of neuromelanin granules in humans, their enrichment and in-depth characterization from human substantia nigra is necessary. Previously published global proteome studies of neuromelanin granules in human substantia nigra required high tissue amounts. Due to the limited availability of human brain tissue we established a new method based on laser microdissection combined with mass spectrometry for the isolation and analysis of neuromelanin granules. With this method it is possible for the first time to isolate a sufficient amount of neuromelanin granules for global proteomics analysis from ten 10 μm tissue sections. In total 1,000 proteins were identified associated with neuromelanin granules. More than 68% of those proteins were also identified in previously performed studies. Our results confirm and further extend previously described findings, supporting the connection of neuromelanin granules to iron homeostasis and lysosomes or endosomes. Hence, this method is suitable for the donor specific enrichment and proteomic analysis of neuromelanin granules.
DPF3 (BAF45c) is a member of the BAF chromatin remodeling complex. Two isoforms have been described, namely DPF3a and DPF3b. The latter binds to acetylated and methylated lysine residues of histones. Here, we elaborate on the role of DPF3a and describe a novel pathway of cardiac gene transcription leading to pathological cardiac hypertrophy. Upon hypertrophic stimuli, casein kinase 2 phosphorylates DPF3a at serine 348. This initiates the interaction of DPF3a with the transcriptional repressors HEY, followed by the release of HEY from the DNA. Moreover, BRG1 is bound by DPF3a, and is thus recruited to HEY genomic targets upon interaction of the two components. Consequently, the transcription of downstream targets such as NPPA and GATA4 is initiated and pathological cardiac hypertrophy is established. In human, DPF3a is significantly up-regulated in hypertrophic hearts of patients with hypertrophic cardiomyopathy or aortic stenosis. Taken together, we show that activation of DPF3a upon hypertrophic stimuli switches cardiac fetal gene expression from being silenced by HEY to being activated by BRG1. Thus, we present a novel pathway for pathological cardiac hypertrophy, whose inhibition is a long-term therapeutic goal for the treatment of the course of heart failure.
Neurofilament depletion improves microtubule dynamics via modulation of Stat3/stathmin signaling
(2016)
In neurons, microtubules form a dense array within axons, and the stability and function of this microtubule network is modulated by neurofilaments. Accumulation of neurofilaments has been observed in several forms of neurodegenerative diseases, but the mechanisms how elevated neurofilament levels destabilize axons are unknown so far. Here, we show that increased neurofilament expression in motor nerves of pmn mutant mice, a model of motoneuron disease, causes disturbed microtubule dynamics. The disease is caused by a point mutation in the tubulin-specific chaperone E (Tbce) gene, leading to an exchange of the most C-terminal amino acid tryptophan to glycine. As a consequence, the TBCE protein becomes instable which then results in destabilization of axonal microtubules and defects in axonal transport, in particular in motoneurons. Depletion of neurofilament increases the number and regrowth of microtubules in pmn mutant motoneurons and restores axon elongation. This effect is mediated by interaction of neurofilament with the stathmin complex. Accumulating neurofilaments associate with stathmin in axons of pmn mutant motoneurons. Depletion of neurofilament by Nefl knockout increases Stat3-stathmin interaction and stabilizes the microtubules in pmn mutant motoneurons. Consequently, counteracting enhanced neurofilament expression improves axonal maintenance and prolongs survival of pmn mutant mice. We propose that this mechanism could also be relevant for other neurodegenerative diseases in which neurofilament accumulation and loss of microtubules are prominent features.
Background
Agalsidase beta is a form of enzyme replacement therapy for Fabry disease, a genetic disorder characterised by low alpha-galactosidase A activity, accumulation of glycosphingolipids and life-threatening cardiovascular, renal and cerebrovascular events. In clinical trials, agalsidase beta cleared glycolipid deposits from endothelial cells within 6 months; clearance from other cell types required sustained treatment. We hypothesised that there might be a 'lag time' to clinical benefit after initiating agalsidase beta treatment, and analysed the incidence of severe clinical events over time in patients receiving agalsidase beta.
Methods
The incidence of severe clinical events (renal failure, cardiac events, stroke, death) was studied in 1044 adult patients (641 men, 403 women) enrolled in the Fabry Registry who received agalsidase beta (average dose 1 mg/kg every 2 weeks) for up to 5 years.
Results
The incidence of all severe clinical events was 111 per 1000 person-years (95% CI 84 to 145) during the first 6 months. After 6 months, the incidence decreased and remained stable within the range of 40-58 events per 1000 patient-years. The largest decrease in incidence rates was among male patients and those aged >= 40 years when agalsidase beta was initiated.
Conclusions
Contrary to the expected increased incidence of severe clinical events with time, adult patients with Fabry disease had decreased incidence of severe clinical events after 6 months treatment with agalsidase beta 1 mg/kg every 2 weeks.