Refine
Year of publication
Document Type
- Conference Proceeding (202) (remove)
Language
- English (108)
- German (86)
- French (5)
- Multiple languages (3)
Keywords
- Psychologie (17)
- Kongress (9)
- Schwertkärpfling (7)
- Immunbiologie (5)
- PET (5)
- Archäologie (4)
- Tagung (4)
- Toxikologie (4)
- Virtuelle Realität (4)
- Vor- und Frühgeschichte (4)
- positron emission tomography (4)
- Archaeology (3)
- Bavaria (3)
- Bayern (3)
- Begabung (3)
- Conference (3)
- Geschichte (3)
- HIV (3)
- Interkulturelles Lernen (3)
- Judit <Buch> (3)
- Judith <Book> (3)
- Kontinentales Tiefbohrprogramm (3)
- Krebs <Medizin> (3)
- Lehrerbildung (3)
- Medienkompetenz (3)
- Neolithic (3)
- Neolithikum (3)
- Prehistory (3)
- artificial intelligence (3)
- 18F-FDG (2)
- Alkohol (2)
- Augmented Reality (2)
- Creation (2)
- DaTscan (2)
- Digital Humanities (2)
- Extended Reality (2)
- Gen (2)
- Geochemie (2)
- Gewalt (2)
- Interaktion (2)
- International Comparative Research (2)
- Ioflupane (2)
- Kognitive Entwicklung (2)
- Krieg (2)
- Längsschnittuntersuchung (2)
- Museum (2)
- Parkinson (2)
- Parkinson Disease (2)
- Parkinson-Krankheit (2)
- Positronen-Emissions-Tomografie (2)
- SPECT (2)
- Schöpfung (2)
- Social VR (2)
- TETCs (2)
- Umweltfaktor (2)
- Umweltschutz (2)
- Virtual Reality (2)
- Wirtschaft (2)
- Würzburg (2)
- ageing (2)
- automation (2)
- economics (2)
- history (2)
- humanities (2)
- molecular imaging (2)
- 11C-HED (1)
- 177Lu-DOTATATE (1)
- 177Lu-DOTATOC (1)
- 18F-LMI1195 (1)
- 1994> (1)
- Accessibility (1)
- Animal Studies (1)
- Anton Ulrich, Braunschweig-Lüneburg, Herzog (1)
- Anton Ulrich, Braunschweig-Lüneburg, Herzog / Octavia (1)
- Anwendungsfall (1)
- Aryl Hydrocarbon Hydroxylase (1)
- Aufsatzsammlung (1)
- Auskunftsdienst (1)
- Automatisierung (1)
- Barrierefreiheit (1)
- Benzene (1)
- Benzo(a)pyrene (1)
- Beruf (1)
- Berufliche Qualifikation (1)
- Berufsausbildung (1)
- Berufsplanung (1)
- Berufspraxis (1)
- Berufswahl (1)
- Bewegung (1)
- Biologie (1)
- Blutalkohol (1)
- CHI Conference (1)
- CSDP (1)
- Carcinogen (1)
- Carcinogenese (1)
- Carcinogens (1)
- China (1)
- Codex (1)
- Computerspiel (1)
- Covalent binding index (1)
- Cultural Animal Studies (1)
- Cultural Studies (1)
- DNA (1)
- DNA Binding (1)
- DNA-Binding (1)
- Data Modeling (1)
- Datenkommunikationsnetz (1)
- Datenmodell (1)
- Design and Development (1)
- Deutsche Gesellschaft für Psychologie / Fachgruppe Medienpsychologie (1)
- Diabetes (1)
- Dieldrin (1)
- DigCompEdu (1)
- Digital Capabilities (1)
- Digitalisierung (1)
- Diskursanalyse (1)
- Domänenadaption (1)
- Drahtloses Sensorsystem (1)
- E-Government (1)
- ECG (1)
- ECG-gated (1)
- EKG (1)
- Ecocriticism (1)
- Embryonalentwicklung (1)
- Entrepreneurship (1)
- Entwicklung (1)
- Entwicklungspsychologie (1)
- Entwicklungspsychologie / Kongress / Trier <1985> (1)
- Environmental Humanities (1)
- Enzyme (1)
- Erinnerung (1)
- Essen <1985> (1)
- Etrusker (1)
- Europäische Sicherheits- und Verteidigungspolitik (1)
- Extremal–I–Verteilung (1)
- Fachgespräch (1)
- Fachliteratur (1)
- Fachsprache (1)
- Fertilität (1)
- Festschrift (1)
- Figurenerkennung (1)
- Fische (1)
- Flugkörper (1)
- Formation Flight (1)
- Frau (1)
- Friedenssicherung (1)
- Frömmigkeit (1)
- GSVP (1)
- Gebet (1)
- Gedächtnisbildung (1)
- Geisteswissenschaftliches Studium (1)
- Geistiges Eigentum (1)
- Genyue ji (1)
- Geographie (1)
- Geschichte 1100-1600 (1)
- Geschichtsstudium (1)
- Geschlechterrolle (1)
- Gesellschaften ohne Zentralgewalt (1)
- Gestik (1)
- Gewalttätigkeit (1)
- Gumbel-Verteilung (1)
- Herpesviren (1)
- Herrschaft (1)
- Herz (1)
- Heterotransplantation (1)
- Historiker (1)
- Huayanggong jishi (1)
- Human-Animal Studies (1)
- Human-centered computing / Access (1)
- Human-centered computing / Human computer interaction (HCI) / Interaction paradigms / Mixed / augmented reality (1)
- Human-centered computing / Human computer interaction (HCI) / Interaction paradigms / Virtual reality (1)
- Human-centered computing / Human computer interaction (HCI) / Interactiondevices (1)
- Human-centered computing / Human computerinteraction (HCI) / Interaction techniques (1)
- II.> (1)
- ISPMF (1)
- Identität (1)
- In vivo (1)
- Induction (1)
- Informationssystem (1)
- Inklusion (1)
- Innovationsforschung (1)
- Innovationsmanagement (1)
- Innovationspotenzial (1)
- Instrument Control Toolbox (1)
- Intelligenzleistung (1)
- Interkulturelle Kompetenz (1)
- Internationales Recht (1)
- Internet (1)
- Italien (1)
- Jazz (1)
- Jugendkultur (1)
- Justiz (1)
- Kaifeng (1)
- Kaiser Huizong (1)
- Kind (1)
- Kinderlosigkeit (1)
- Kirche (1)
- Klinische Psychologie (1)
- Kognitive Kompetenz (1)
- Konflikt (1)
- Konfliktvermeidung (1)
- Kongreß (1)
- Kreativ- und Kulturwirtschaft (1)
- Krisenmanagement (1)
- Kultur (1)
- Kulturwirtschaft (1)
- Kunst (1)
- Kunst- und Kulturtransfer (1)
- Künstliche Intelligenz (1)
- Landschaftsgarten (1)
- Lehrdichtung (1)
- Leibniz, Gottfried Wilhelm (1)
- Lekythenbemalung (1)
- Lernen (1)
- Lesen (1)
- Literary Studies (1)
- Literatur (1)
- MASI (1)
- MIBG (1)
- Macaranga (1)
- Maccabean books (1)
- Macht (1)
- Magdeburg <1994> (1)
- Mainfranken Theater (1)
- Makkabäer <Buch (1)
- Media Didactica (1)
- Media Psychology (1)
- Media Psychology Division (1)
- Medien (1)
- Medienanalyse (1)
- Medienkommunikation (1)
- Medienpsychologie (1)
- Medizinische Psychologie (1)
- Mensch-Maschine-Kommunikation (1)
- Metabolic activation (1)
- Metaiodobenzylguanidine (1)
- Metaverse (1)
- Millimeterwelle (1)
- Mimik (1)
- Mittelalter (1)
- Multilateralismus (1)
- Museumspädagogik (1)
- Muster (1)
- Myokarditis (1)
- Named-Entity-Recognition (1)
- Netzvirtualisierung (1)
- Neuroendocrine Tumor (1)
- Niger (1)
- Nonverbal (1)
- Norm (1)
- Onkogen (1)
- Open Science (1)
- PRRT (1)
- Partner für Innovation (1)
- Partzipation (1)
- Pflanzen (1)
- Phenobarbitone (1)
- Physiologische Chemie (1)
- Physiologische Psychologie (1)
- Pigmentmuster (1)
- Pragmatik (1)
- Prayer (1)
- Produktinnovation (1)
- Programmheft (1)
- Psychologie / Kongress / Zeitschrift (1)
- Psychomotorik (1)
- Psychopharmakologie (1)
- Psychotherapie (1)
- Quadrocopter (1)
- RNS (1)
- Rats (1)
- Rauschgift (1)
- Reactive intermediates (1)
- Rechnernetz (1)
- Rede (1)
- Regulierung (1)
- Renaissance (1)
- Reziprozität (1)
- Rom (1)
- Sachkultur (1)
- San Diego <Calif. (1)
- Schreiben (1)
- Schöpfungslehre (1)
- Selbsteinschätzung (1)
- Selbstverwirklichung (1)
- Skorpion (1)
- Social Virtual Reality (1)
- Song Huizong <China, Kaiser> (1)
- Soziale Situation (1)
- Sozialinnovation (1)
- Soziologie des Dritten (1)
- Speech <Address> (1)
- Spumaviren (1)
- Standard (1)
- Standardisierung (1)
- Structureactivity relationship (1)
- Südliche Songdynstie (1)
- T-Pattern (1)
- TETC (1)
- TKI (1)
- Technische Innovation (1)
- Theme (1)
- Transplantation (1)
- Tumor (1)
- Tyrannenmord <Motiv> (1)
- Tyrannicide (1)
- UN-Friedenssicherung (1)
- UN-peacekeeping (1)
- Ultrastruktur (1)
- Universität (1)
- Universitätsbibliothek (1)
- Unmanned Aerial Vehicle (1)
- Unternehmenskultur (1)
- Unterostfränkisch (1)
- Untersuchungsinstrument (1)
- Use case (1)
- Variety (1)
- Varietät (1)
- Vasenmaler (1)
- Veranstaltung (1)
- Verhaltensanalyse (1)
- Verhaltensbiologie (1)
- Verhaltensmuster (1)
- Verhaltenssteuerung (1)
- Verwaltung (1)
- Violence (1)
- Virtual Research Environment (1)
- Virtualisierung (1)
- Vorschulkind (1)
- War (1)
- Wiesbaden <1985> (1)
- Wissen (1)
- Wissenschaftssprache (1)
- Wissensliteratur (1)
- Wissensorganisation (1)
- Zentralgewalt (1)
- agent-based models (1)
- anti-RNA polymerase I antibodies (1)
- antidepressants (1)
- autonomic nervous system (1)
- business culture (1)
- cardiac (1)
- cognitive impairment (1)
- collaboratories (1)
- crisis management (1)
- dementia (1)
- detection (1)
- diabetische Kardiomyopathie (1)
- discourse analysis (1)
- educational games (1)
- entrepreneurship (1)
- extended reality (1)
- extreme value distribution (1)
- fibrillar centers (1)
- follow-up (1)
- food (1)
- future Internet architecture (1)
- game mechanics (1)
- games (1)
- generalized Pareto distribution (1)
- hackathons (1)
- heart (1)
- human behaviour (1)
- hydroxyephedrine (1)
- immersive learning technologies (1)
- immersive technologies (1)
- innovation (1)
- intellectual property (1)
- inter-organisational relations (1)
- inter-organisationale Beziehungen (1)
- interactive authoring system (1)
- künstliche Intelligenz (1)
- locomotion (1)
- mIBG (1)
- materielle Kultur (1)
- media communication (1)
- medicine (1)
- moycardial sympathetic innervation (1)
- multilateralism (1)
- multimodal learning (1)
- myocarditis (1)
- natural language processing · · · (1)
- natural user interfaces (1)
- negative Reziprozität (1)
- network virtualization (1)
- nucleolus (1)
- nucleolus organizer (1)
- nutrition (1)
- phytochemistry (1)
- phytomedicine (1)
- phytoneering (1)
- political discourse (1)
- politischer Diskurs (1)
- pragmatics (1)
- procedural content generation (1)
- psychomotor training (1)
- rRNA genes (1)
- regulation (1)
- ribosomal RNA genes; electron microscopy; spread preparations (1)
- self-assembly (1)
- semantic understanding (1)
- sensor devices (1)
- sensor network (1)
- social interaction (1)
- standardization (1)
- sympathetic nerve (1)
- theranostics (1)
- user-generated content (1)
- vandetanib (1)
- virtual reality (1)
- wireless network (1)
- workflow platform (1)
Institute
- Institut für Psychologie (bis Sept. 2007) (47)
- Theodor-Boveri-Institut für Biowissenschaften (26)
- Institut für Mineralogie und Kristallstrukturlehre (12)
- Institut für Psychologie (12)
- Klinik und Poliklinik für Allgemein-, Viszeral-, Gefäß- und Kinderchirurgie (Chirurgische Klinik I) (12)
- Neuphilologisches Institut - Moderne Fremdsprachen (bis 2007) (12)
- Institut für Informatik (11)
- Institut für deutsche Philologie (11)
- Klinik und Poliklinik für Nuklearmedizin (9)
- Institut für Pharmakologie und Toxikologie (6)
Schriftenreihe
Sonstige beteiligte Institutionen
- Johns Hopkins School of Medicine (4)
- Johns Hopkins School of Medicine, Baltimore, MD, U.S. (4)
- Cologne Game Lab (3)
- Open University of the Netherlands (2)
- Badisches Landesmuseum Karlsruhe (1)
- Bayerische Museumsakademie (1)
- Bezirk Unterfranken (1)
- Birmingham City University (1)
- Brown University (1)
- DATE Lab, KITE Research Insititute, University Health Network, Toronto, Canada (1)
EU-Project number / Contract (GA) number
- 701983 (9)
Both research and policy indicate the importance of considering ICT-related and intercultural competence development in education together. Teacher educators play a significant role in the development of these related competencies. The aim of this study is to analyze ICT- related competence frameworks addressing teacher educators, focusing on how they incorporate intercultural considerations. We analyze four internationally recognized models—Teacher Educator Technology Competencies (TETCs), DigCompEdu, Jisc Digital Capabilities, and Media Didactica—showing that with the TETCs important steps have been taken to integrate both discourses, while the other frameworks treat aspects related to culture as isolated phenomena. In TETC 8, the global dimension is represented by a specific competency, which is also differentiated into specific areas of competence. This offers a strong starting point for further international discourse, in terms of both the diversification of underlying theoretical concepts and approaches to culturally responsive education. Further research is needed to investigate how professional development can meet the needs of teacher educators in a global context.
The combination of globalization and digitalization emphasizes the importance of media-related and intercultural competencies of teacher educators and preservice teachers. This article reports on the initial prototypical implementation of a pedagogical concept to foster such competencies of preservice teachers. The proposed pedagogical concept utilizes a social virtual reality (VR) framework since related work on the characteristics of VR has indicated that this medium is particularly well suited for intercultural professional development processes. The development is integrated into a larger design-based research approach that develops a theory-guided and empirically grounded professional development concept for teacher educators with a special focus on teacher educator technology competencies (TETC8). TETCs provide a suitable competence framework capable of aligning requirements for both media-related and intercultural competencies. In an exploratory study with student teachers, we designed, implemented, and evaluated a pedagogical concept. Reflection reports were qualitatively analyzed to gain insights into factors that facilitate or hinder the implementation of the immersive learning scenario as well as into the participants’ evaluation of their learning experience. The results show that our proposed pedagogical concept is particularly suitable for promoting the experience of social presence, agency, and empathy in the group.
In this paper, we bridge the gap between procedural content generation (PCG) and user-generated content (UGC) by proposing and demonstrating an interactive agent-based model of self-assembling ensembles that can be directed though user input. We motivate these efforts by considering the opportunities technology provides to pursue game designs based on according game design frameworks. We present three different use cases of the proposed model that emphasize its potential to (1) self-assemble into predefined 3D graphical assets, (2) define new structures in the context of virtual environments by self-assembling layers on the surfaces of arbitrary 3D objects, and (3) allow novel structures to self-assemble only considering the model’s configuration and no external dependencies. To address the performance restrictions in computer games, we realized the prototypical model implementation by means of an efficient entity component system (ECS). We conclude the paper with an outlook on future steps to further explore novel interactive, dynamic PCG mechanics and to ensure their efficiency.
Fertilität und Macht: Die Reproduktionspflicht mittelalterlicher Herrscherinnen und Herrscher
(2021)
Fertility was a key theme of medieval rulership. To conceive and give birth to sons – and thus to ensure the succession to the throne – was one of the foremost duties of medieval kings and queens. But what happened when a male child died in infancy, no male child was born, or no pregnancy ever came about? Barrenness could have dramatic consequences in the Middle Ages, for example expulsion, divorce or conflicts over royal succession. Against this historical background, it seems logical that the fate of the childless ruler would be recounted in the form of a ‘Passion narrative’. In the German literature of the Middle Ages, however, there are also interpretative models of a contrary vein to be found. In the year 1220, for instance, Ebernand of Erfurt construed the wedded life of the imperial couple Henry and Kunigunde as a tale of resistance against the royal obligation to reproduce. In his versified legend, composed in the vernacular, the couple secretly agrees not to fulfil society’s expectations, but to lead a chaste marriage. Yet above and beyond legend, childless rulers were also subject to the impact of multifarious legal, religious, medical, narrative and discursive factors. Taking Michel Foucault as a point of departure, this contribution shows how fertility became a field of power on which hierarchies between rulers and subjects, men and women were negotiated, while also shedding light on how religious and secular ideals clashed in the assessment of infertility.
Der Band enthält acht Aufsätze zur Geschichte der Fach- und Wissenschaftssprachen. Disziplinär geht es in erster Linie um juristische, balneologische, sprachwissenschaftliche pharmazeutische, medizinische Fach- und Wissenschaftssprachen. Darüber hinaus thematisiert ein Beitrag die Problematik der Fachsprachen im Rahmen der Stadtsprachenforschung, ein weiterer die Sprach- und Textpraxis von Vorlesungen.
As part of the Clash of Realities International Conference on the Technology and Theory of Digital Games, the Game Technology Summit is a premium venue to bring together experts from academia and industry to disseminate state-of-the-art research on trending technology topics in digital games. In this first iteration of the Game Technology Summit, we specifically paid attention on how the successes in AI in Natural User Interfaces have been impacting the games industry (industry track) and which scientific, state-of-the-art ideas and approaches are currently pursued (scientific track).
Immersive, sensor-enabled technologies such as augmented and virtual reality expand the way human beings interact with computers significantly. While these technologies are widely explored in entertainment games, they also offer possibilities for educational use. However,their uptake in education is so far very limited. Within the ImTech4Ed project, we aim at systematically exploring the power of interdisciplinary, international hackathons as a novel method to create immersive educational game prototypes and as a means to transfer these innovative technical prototypes into educational use. To achieve this, we bring together game design and development, where immersive and interactive solutions are designed and developed; computer science, where the technological foundations for immersive technologies and for scalable architectures for these are created; and teacher education, where future teachers are educated. This article reports on the concept and design of these hackathons.
Immersive virtual environments provide users with the opportunity to escape from the real world, but scripted dialogues can disrupt the presence within the world the user is trying to escape within. Both Non-Playable Character (NPC) to Player and NPC to NPC dialogue can be non-natural and the reliance on responding with pre-defined dialogue does not always meet the players emotional expectations or provide responses appropriate to the given context or world states. This paper investigates the application of Artificial Intelligence (AI) and Natural Language Processing to generate dynamic human-like responses within a themed virtual world. Each thematic has been analysed against humangenerated responses for the same seed and demonstrates invariance of rating across a range of model sizes, but shows an effect of theme and the size of the corpus used for fine-tuning the context for the game world.
Modern immersive multimodal technologies enable the learners to completely get immersed in various learning situations in a way that feels like experiencing an authentic learning environment. These environments also allow the collection of multimodal data, which can be used with artificial intelligence to further improve the immersion and learning outcomes. The use of artificial intelligence has been widely explored for the interpretation of multimodal data collected from multiple sensors, thus giving insights to support learners’ performance by providing personalised feedback. In this paper, we present a conceptual approach for creating immersive learning environments, integrated with multi-sensor setup to help learners improve their psychomotor skills in a remote setting.
Vom 16. bis 18. November 2018 fand im Kloster Windberg bei Straubing zum dritten Mal nach 2014 eine Tagung unter dem Titel "Neue Materialien des Bayerischen Neolithikums" statt. Dabei wurden neue, bislang unpublizierte Fundkomplexe vorgestellt und diskutiert, die alle Phasen der Jungsteinzeit vom Altneolithikum bis zum Endneolithikum abdeckten und die aus verschiedenen Landesteilen des Freistaats Bayern stammen. Mit einer diachronen und Regionen übergreifenden Betrachtung charakteristischer Inventare aus den verschiedenen Landschaftsräumen und Zeitabschnitten wurde das Ziel verfolgt, neues Material zu erschließen und damit die archäologische Quellenbasis zu erweitern und der Neolithforschung in Bayern neue Impulse zu geben. Im vorliegenden Band werden sieben der Vorträge dieser Tagung sowie drei Beiträge der vorangegangenen Arbeitstreffen zusammengestellt.
Texts, Animals, Environments. Zoopoetics and Ecopoetics probes the multiple links between ecocriticism and animal studies, assessing the relations between animals, environments and poetics. While ecocriticism usually relies on a relational approach to explore phenomena related to the environment or ecology more broadly, animal studies tends to examine individual or species-specific aspects. As a consequence, ecocriticism concentrates on ecopoetical, animal studies on zoopoetical elements and modes of representation in literature (and the arts more generally). Bringing key concepts of ecocriticism and animal studies into dialogue, the volume explores new ways of thinking about and reading texts, animals, and environments – not as separate entities but as part of the same collective.
Vom 18. bis 20. November 2016 fand im Kloster Windberg bei Straubing zum zweiten Mal nach 2014 eine Tagung unter dem Titel "Neue Materialien des Bayerischen Neolithikums" statt. Dabei wurden neue, bislang unpublizierte Fundkomplexe vorgestellt und diskutiert, die alle Phasen der Jungsteinzeit vom Altneolithikum bis zum Endneolithikum abdeckten und die aus verschiedenen Landesteilen des Freistaats Bayern sowie aus dem benachbarten Oberschwaben stammten. Mit einer diachronen und Regionen übergreifenden Betrachtung charakteristischer Inventare aus den verschiedenen Landschaftsräumen und Zeitabschnitten wurde das Ziel verfolgt, neues Material zu erschließen und damit die archäologische Quellenbasis zu erweitern und der Neolithforschung in Bayern neue Impulse zu geben. Im vorliegenden Band sind acht der Vorträge dieser Tagung zusammen gestellt.
Einleitung: Die linksventrikuläre diastolische Dysfunktion (LVDD) ist bei Diabetikern noch vor Entwicklung einer klinisch apparenten Herzinsuffizienz eines der ersten Anzeichen einer kardialen Beteiligung. Daher soll in dieser Studie untersucht werden, ob die LVDD mit ECG-gated F-18-FDG PET in einem Diabetes-Rattenmodell dargestellt werden kann.
Methodik: Es wurden F-18-FDG PET Scans in einem Typ-2-Diabetes Rattenmodell (ZDF fa/fa, n=6) und in ZL Kontrollen (n=6) vorgenommen (Alter, jeweils 13 Wochen). Unter Hyperinsulinemic-Euglycemic Clamp-Technik wurden 37 MBq 18F-FDG über die Schwanzvene appliziert. 15-35 Minuten nach Tracergabe wurden mittels eines Kleintier-PET-Scanners sowie unter EKG-Ableitung PET Scans angefertigt (16 frames/cardiac cycle). Die linksventrikuläre Ejektionsfraktion (EF) und die Peak Füllrate (PFR) wurden mittels einer geeigneten Software (Heart Function View) gemessen, wobei die Software an die Größe des Rattenherzes angepasst wurde.
Ergebnisse: Im Alter von 13 Wochen entwickeln ZDF Diabetes-Ratten eine im Vergleich zu Kontrolltieren eine signifikante myokardiale Hypertrophie, bestätigt durch post-mortem Analyse des Herzgewichtes (994±78mg vs. 871±44mg in ZDF Diabetes-Ratten vs. ZL Kontrollen, p<0.01). ECG-gated PET zeigte eine signifikante Abnahme der LV diastolischen PFR (10.4±0.5 vs. 11.8±0.4 EDV/sec in ZDF Diabetes-Ratten vs. ZL Kontrollen, p<0.001), jedoch zeigte sich kein signifikanter Unterschied zwischen LVEF und der Herzfrequenz in den untersuchten ZDF Diabetes-Ratten und Kontrollen (LVEF: 60.0±4.5 vs. 63.7±4.1%, n.s. und HR: 305±25 vs. 323±24 bpm, n.s.).
Schlussfolgerung: Im Diabetes-Ratten-Modell kann unter Verwendung eines ECG-gated FDG-PET Protokolls die diastolische Dysfunktion als Parameter der frühen diabetischen Kardiomyopathie nachgewiesen werden.
Introduction: The prognosis of medullary thyroid carcinoma (MTC) is poor using common chemotherapeutic approaches. However, during the last years encouraging results of recently introduced tyrosine kinase inhibitors (TKI) such as vandetanib have been published. In this study we aimed to correlate the results of \(^{18}\)F-fluorodeoxyglucose ([\(^{18}\)F]FDG) positron emission tomography (PET) imaging with treatment outcome.
Methods: Eighteen patients after thyroidectomy with recurrent/advanced MTC lesions receiving vandetanib (300 mg orally/day) could be analysed. A baseline \(^{18}\)F-FDG PET prior to and a follow-up \(^{18}\)F-FDG PET 3 months after TKI initiation were performed. During follow-up, tumor progression was assessed every 3 months including computed tomography according to RECIST. Progression-free survival (PFS) was correlated with the maximum standardized uptake value of \(^{18}\)F-FDG in lymph nodes (SUV(LN)max) or visceral metastases (SUV(MTS)max) as well as with clinical parameters using ROC analysis.
Results: Within median 3.6 years of follow-up, 9 patients showed disease progression at median 8.5 months after TKI initiation. An elevated glucose consumption assessed by baseline \(^{18}\)F-FDG PET (SUV(LN)max > 7.25) could predict a shorter PFS (2 y) with an accuracy of 76.5% (SUV(LN)max <7.25, 4.3 y; p=0.03). Accordingly, preserved tumor metabolism in the follow-up PET (SUV(MTS)max >2.7) also demonstrated an unfavorable prognosis (accuracy, 85.7%). On the other hand, none of the clinical parameters reached significance in response prediction.
Conclusions: In patients with advanced and progressive MTC, tumors with higher metabolic activity at baseline are more aggressive and more prone to progression as reflected by a shorter PFS; they should be monitored more closely. Preserved glucose consumption 3 months after treatment initiation was also related to poorer prognosis.