Refine
Is part of the Bibliography
- yes (635)
Year of publication
Document Type
- Journal article (320)
- Doctoral Thesis (312)
- Conference Proceeding (3)
Keywords
- Herzinsuffizienz (31)
- heart failure (21)
- myocardial infarction (21)
- Diabetes mellitus (19)
- Herzinfarkt (19)
- chronic kidney disease (19)
- adrenocortical carcinoma (17)
- Fabry disease (16)
- mortality (15)
- hemodialysis (14)
- inflammation (14)
- echocardiography (12)
- Chronische Herzinsuffizienz (10)
- Morbus Fabry (10)
- Myokardinfarkt (10)
- Nebenniere (10)
- prognosis (10)
- Arteriosklerose (9)
- Fabry-Krankheit (9)
- Hämodialyse (9)
- MRI (9)
- Transthorakale Echokardiographie (9)
- atherosclerosis (9)
- depression (9)
- Atherosklerose (8)
- CXCR4 (8)
- Nebennierenrindenkarzinom (8)
- Nebennierenrindenkrebs (8)
- PET (8)
- biomarker (8)
- diabetes (8)
- enzyme replacement therapy (8)
- heart (8)
- therapy (8)
- Depression (7)
- Heart failure (7)
- Sterblichkeit (7)
- Stickstoffmonoxid (7)
- cardiomyopathy (7)
- diabetes mellitus (7)
- oxidative stress (7)
- Aortenklappenstenose (6)
- Aortenstenose (6)
- Chronische Niereninsuffizienz (6)
- Dialyse (6)
- TAVI (6)
- coronary artery disease (6)
- cortisol (6)
- dialysis (6)
- eNOS (6)
- fibrosis (6)
- hypertension (6)
- obesity (6)
- Biomarker (5)
- Echokardiographie (5)
- Endothel (5)
- Hypertonie (5)
- Kardiologie (5)
- Kernspintomografie (5)
- Koronare Herzkrankheit (5)
- Lebensqualität (5)
- Mausmodell (5)
- NMR-Tomographie (5)
- Nebennierenkarzinom (5)
- Nebennierentumor (5)
- Niereninsuffizienz (5)
- Nierentransplantation (5)
- Remodeling (5)
- Reperfusion (5)
- Simulation (5)
- Strahlentherapie (5)
- Ultraschallkardiographie (5)
- anxiety (5)
- biomarkers (5)
- blood pressure (5)
- cardiovascular disease (5)
- cardiovascular diseases (5)
- chronic heart failure (5)
- coronary heart disease (5)
- kidney (5)
- mice (5)
- mouse (5)
- prevalence (5)
- risk factors (5)
- type 2 diabetes (5)
- 18F-FDG (4)
- ACC (4)
- Aldosteron (4)
- Aortenklappenersatz (4)
- Apoptosis (4)
- Chemotherapie (4)
- Cushing’s syndrome (4)
- DHEA (4)
- Dehydroepiandrosteron (4)
- EKG (4)
- Elektrokardiogramm (4)
- FGFR (4)
- Fettsucht (4)
- Herzhypertrophie (4)
- Herzkatheter (4)
- Herzmuskel (4)
- Hyperaldosteronismus (4)
- Inflammation (4)
- Lungenfibrose (4)
- Maus (4)
- Myokarditis (4)
- Nebenniereninsuffizienz (4)
- Nebennierenrindeninsuffizienz (4)
- Nierenfunktion (4)
- Positronen-Emissions-Tomografie (4)
- Prognose (4)
- Ratte (4)
- Sepsis (4)
- Training (4)
- Urämietoxine (4)
- Zellkultur (4)
- acute heart failure (4)
- akute Herzinsuffizienz (4)
- cardiac hypertrophy (4)
- cardiovascular events (4)
- cognitive decline (4)
- cytokines (4)
- diagnosis (4)
- end-stage renal disease (4)
- epidemiology (4)
- genetics (4)
- hypercortisolism (4)
- immune response (4)
- ischemia (4)
- ischemic stroke (4)
- metabolomics (4)
- miRNA (4)
- paraganglioma (4)
- pheochromocytoma (4)
- positron emission tomography (4)
- quality of life (4)
- radial (4)
- reperfusion (4)
- survival (4)
- treatment (4)
- ACTH (3)
- Adipositas (3)
- Akutes Nierenversagen (3)
- Anämie (3)
- CMR (3)
- COVID-19 (3)
- CYP11B2 (3)
- Chemokine (3)
- Diabetes (3)
- Doppler-Echokardiographie (3)
- ECG (3)
- Endotheldysfunktion (3)
- Entzündung (3)
- Enzymersatztherapie (3)
- Erythropoietin (3)
- Fabry (3)
- Fibrose (3)
- Gewebedoppler (3)
- Guanylatcyclase (3)
- HFmrEF (3)
- Herzfrequenz (3)
- Immunreaktion (3)
- Ischämie (3)
- Kardiomyopathie (3)
- Knockout <Molekulargenetik> (3)
- Low-density-Lipoproteine (3)
- Lysosomale Speicherkrankheit (3)
- Magnetresonanztomographie (3)
- Mitotane (3)
- Myocardial infarction (3)
- Nebennierenkrise (3)
- Nebennierenrinde (3)
- Oxidativer Stress (3)
- Phäochromozytom (3)
- Prevalence (3)
- Prädiktoren (3)
- SOAT1 (3)
- Sarkoidose (3)
- Thrombozyt (3)
- USP8 (3)
- Urämie (3)
- adrenal (3)
- adrenocortical cancer (3)
- biocompatibility (3)
- blood (3)
- body mass index (3)
- bone (3)
- cardiac magnetic resonance imaging (3)
- cardiology (3)
- cardiovascular risk factors (3)
- cognitive impairment (3)
- desmin (3)
- diet (3)
- follow-up (3)
- guideline adherence (3)
- guidelines (3)
- haemodialysis (3)
- heart rate (3)
- hypertrophic cardiomyopathy (3)
- immunohistochemistry (3)
- impact (3)
- infarction (3)
- left ventricular ejection fraction (3)
- left ventricular hypertrophy (3)
- liraglutide (3)
- lymphocytes (3)
- machine learning (3)
- magnetic resonance imaging (3)
- management (3)
- medicine (3)
- melanoma (3)
- mitotane (3)
- multicenter (3)
- nitric oxide (3)
- outcomes (3)
- platelets (3)
- prognostic factors (3)
- receptor (3)
- recurrence (3)
- renal function (3)
- safety (3)
- sepsis (3)
- sleeve gastrectomy (3)
- sudden cardiac death (3)
- theranostics (3)
- uremic toxin (3)
- uremic toxins (3)
- vandetanib (3)
- vitamin D (3)
- wall shear stress (3)
- 4D flow (2)
- ADMA (2)
- Adiponektin (2)
- Adrenocortical Carcinoma (2)
- Aging (2)
- Aldosteronsynthaseinhibitor (2)
- Alter (2)
- Anaplastisches Schilddrüsenkarzinom (2)
- Aorta (2)
- Aortic valve stenosis (2)
- Apoptose (2)
- Arterielle Gefäßsteifigkeit (2)
- Atherosclerosis (2)
- Atorvastatin (2)
- Autoantikörper (2)
- B-scan-Ultraschallkardiographie (2)
- Beschleunigungssensor (2)
- Beta-1-Rezeptor (2)
- Biokompatibilität (2)
- Bluthochdruck (2)
- C-X-C motif chemokine receptor 4 (2)
- CCR7 (2)
- CKD (2)
- CVD (2)
- CXCR7 (2)
- CYP11B1 (2)
- CYP2W1 (2)
- Calcium (2)
- Catecholamine (2)
- Chemokinrezeptor (2)
- Chronic kidney disease (2)
- Chronotrope Inkompetenz (2)
- Cushing-Syndrom (2)
- Cushing’s disease (2)
- DHEAS (2)
- DNS-Topoisomerasen (2)
- Diagnostik (2)
- Dilatation (2)
- ETiCS (2)
- Eisenmangel (2)
- Elektrophysiologische Untersuchung (2)
- Endokrinologie (2)
- Endothelial dysfunction (2)
- Endotheliale Dysfunktion (2)
- Endothelzellen (2)
- Enzyme replacement therapy (2)
- Eplerenone (2)
- Ezetimib (2)
- FGF-pathway (2)
- Fabry genotype (2)
- Fabry nephropathy (2)
- Fabry phenotype (2)
- Fibroblast (2)
- GFAP (2)
- Germany (2)
- HFrEF (2)
- HGF (2)
- Hepatozyten-Wachstumsfaktor (2)
- Herzdekompensation (2)
- Herzfrequenzvariabilität (2)
- Herzmuskelkrankheit (2)
- Herzschrittmacher (2)
- Hypertension (2)
- Hyponatriämie (2)
- Hämodiafiltration (2)
- Immunantwort (2)
- Immunosuppression (2)
- Immunsuppression (2)
- Immuntherapie (2)
- Implantierbarer Kardioverter-Defibrillator (2)
- Incidentaloma (2)
- Infarktheilung (2)
- Insulinresistenz (2)
- Inzidentalom (2)
- Ionenstärke (2)
- KDIGO (2)
- KHK (2)
- Kardiovaskuläre Risikofaktoren (2)
- Kidney function (2)
- Kidney transplantation (2)
- Kognition (2)
- Kollagen (2)
- Komplement <Immunologie> (2)
- Kontrastmittel (2)
- Koronarangiographie (2)
- Koronarintervention (2)
- Krankheitsverlauf (2)
- Lyso-Gb3 (2)
- MRT (2)
- MTUS1 (2)
- Magenbypass (2)
- Magnetische Kernresonanz (2)
- Makrophagen (2)
- Medicine (2)
- Medizin (2)
- Medullärer Schilddrüsenkrebs (2)
- Mitralinsuffizienz (2)
- Molekulargenetik (2)
- Mortality (2)
- Myokardischämie (2)
- Mäuse (2)
- NAFLD (2)
- NMR (2)
- NMR-Bildgebung (2)
- NO (2)
- NT-proBNP (2)
- Natriumkanal (2)
- Nebennierenrindencarcinom (2)
- Nebivolol (2)
- Nephrologie (2)
- Neurons (2)
- Nicotinamid-N-Methyltransferase (2)
- Nierenversagen (2)
- PD-L1 (2)
- PET-Tracer (2)
- PHQ-9 (2)
- Pathogenese (2)
- Pharmakotherapie (2)
- Prognostische Bedeutung (2)
- Prävention (2)
- Pulswellengeschwindigkeit (2)
- Punktion (2)
- QT-Zeit (2)
- Quality of life (2)
- ROS (2)
- RYGB (2)
- Rezeptor (2)
- RhoA (2)
- Rimonabant (2)
- Risikofaktor (2)
- Roux-en-Y gastric bypass (2)
- Roux-en-Y gastric bypass surgery (2)
- SDMA (2)
- SF-36 (2)
- Schilddrüsenkrebs (2)
- Sensitivity (2)
- Sensitivität (2)
- Septal bulge (2)
- Signaltransduktion (2)
- Simulationstraining (2)
- Spironolacton (2)
- Steroide (2)
- Stickstoffmonoxid-Synthase (2)
- Strainrate (2)
- Streptozocin (2)
- Streptozotocin (2)
- T cells (2)
- T-Lymphozyt (2)
- T-Lymphozyten (2)
- T1rho (2)
- T1ρ (2)
- TKI (2)
- TNF-alpha (2)
- TRIB3 (2)
- Tandem-Massenspektrometrie (2)
- Targeted Metabolomics (2)
- Testosteron (2)
- Therapie (2)
- Thrombozytenaktivierung (2)
- Tiermodell (2)
- Transforming Growth Factor beta (2)
- Transkatheter-Aortenklappenimplantation (2)
- Troponin (2)
- Tumor (2)
- Tumor-Nekrose-Faktor (2)
- Tyrosinkinaseinhibitor (2)
- United States (2)
- Vegetatives Nervensystem (2)
- Verlauf (2)
- Vitamin D (2)
- Vorhofflimmern (2)
- WSS (2)
- Zelllinie (2)
- [68Ga]PentixaFor (2)
- ablation (2)
- accelerometer-sensor (2)
- acute kidney injury (2)
- adenomas (2)
- adrenal crisis (2)
- adrenal insufficiency (2)
- adrenal tumours (2)
- adrenocortical adenoma (2)
- adrenocortical tumors (2)
- age (2)
- aging (2)
- aldosterone (2)
- amyloidosis (2)
- anemia (2)
- aneurysm (2)
- antibodies (2)
- antimicrobial resistance (2)
- aortic arch (2)
- arrhythmia (2)
- arteriosclerosis (2)
- association (2)
- blood flow (2)
- body weight (2)
- calcification (2)
- calcium (2)
- cancer (2)
- cancer treatment (2)
- carbohydrates (2)
- carcinomas (2)
- cardiac (2)
- cardiac MRI (2)
- cardiac device (2)
- cardiac surgery (2)
- cardiovascular genetics (2)
- cardiovascular implantable electronic device (2)
- cardiovascular magnetic resonance (2)
- cardiovascular morbidity (2)
- chemokine receptor (2)
- chemotherapy (2)
- chronic cerebrovascular disease (2)
- chronic kidney-disease (2)
- chronotropic incompetence (2)
- comorbidity (2)
- complement system (2)
- complication (2)
- congestive heart failure (2)
- contractility (2)
- convection volume (2)
- copeptin (2)
- coronary angiography (2)
- costs (2)
- deep learning (2)
- deformation (2)
- dementia (2)
- desmosomes (2)
- dexamethasone suppression test (2)
- dialysis adequacy (2)
- efficacy (2)
- ejection fraction (2)
- endoradiotherapy (2)
- endothelial dysfunction (2)
- endothelial nitric oxide synthase (2)
- endothelial progenitor cells (2)
- endotheliale Vorläuferzellen (2)
- erythropoietin (2)
- fabry disease (2)
- failure (2)
- gastric bypass (2)
- genome-wide association (2)
- glomerular filtration rate (2)
- glycemic control (2)
- hemodiafiltration (2)
- hospitalization (2)
- hypercholesterolemia (2)
- hyperexpression techniques (2)
- identification (2)
- immune cells (2)
- immunotherapy (2)
- insulin resistance (2)
- internal medicine (2)
- kidneys (2)
- left ventricular mass (2)
- lysosomal storage disease (2)
- malnutrition (2)
- mapping (2)
- marrow (2)
- medullary thyroid carcinoma (2)
- metaanalysis (2)
- metabolism (2)
- mineral metabolism (2)
- morbidity (2)
- mouse models (2)
- multiple myeloma (2)
- myocardial work (2)
- nNOS (2)
- natriuretic peptide (2)
- neuroendocrine tumor (2)
- neurofilament light chain (2)
- nitric oxide synthase (2)
- oncology (2)
- osteoporosis (2)
- oxLDL (2)
- parathyroid hormone (2)
- pediatric adrenocortical cancer (2)
- pediatric adrenocortical tumor (2)
- peptide tyrosine tyrosine (PYY) (2)
- physical activity (2)
- placebo-controlled trial (2)
- population (2)
- postmenopausal women (2)
- precision medicine (2)
- primary aldosteronism (2)
- primary prevention (2)
- primärer Hyperaldosteronismus (2)
- prognostic biomarker (2)
- protein binding (2)
- proteinuria (2)
- pulse wave velocity (2)
- quantification (2)
- radiotherapy (RT) (2)
- randomized controlled trial (2)
- rats (2)
- regulatory T cells (2)
- remodeling (2)
- remodelling (2)
- replacement (2)
- restrictive cardiomyopathy (2)
- retrospective (2)
- rimonabant (2)
- sizing (2)
- small interfering RNAs (2)
- spironolactone (2)
- stage renal-disease (2)
- statins (2)
- stem cell transplantation (2)
- stroke (2)
- surgery (2)
- telemetry (2)
- therapeutic drug monitoring (2)
- troponin (2)
- tyrosine kinase inhibitor (2)
- urine (2)
- validation (2)
- zebrafish (2)
- Überlebenszeit (2)
- 1-Methylnicotinamid (1)
- 11-beta-Hydroxylase (1)
- 2- deoxy-2-(18F)fluoro-D-glucose (1)
- 2-deoxy-2-(18F)fluoro-D-glucose (1)
- 2-dimensional speckle tracking (1)
- 2-dimensional strain (1)
- 3 T (1)
- 4D flow MRI (1)
- 4D-Studie (1)
- 7 T (1)
- 7T (1)
- 8p22 (1)
- <sup>18</sup>F-FDG (1)
- <sup>68</sup>Ga-Pentixafor (1)
- A-delta fibers (1)
- A20 (1)
- ACC/AHA classification (1)
- ACE-Hemmer (1)
- ACM (1)
- ACO-Schema (1)
- ACO-scheme (1)
- ADMA/ADMA (1)
- AHF-Register Würzburg (1)
- AKI (1)
- ALT (1)
- AMitis (1)
- APACHE <Klassifikation> (1)
- APCE (1)
- ARDS (acute respiratory distress syndrome) (1)
- ARVC (1)
- ASE formula (1)
- ATP generation (1)
- ATR 101 (1)
- ATRX (1)
- AZD 3988 (1)
- AZD6140 (1)
- Acarbose (1)
- Actin (1)
- Acute kidney injury (1)
- Addison's disease (1)
- Addisons disease (1)
- Adhärenz (1)
- Adipokine (1)
- Adipositaschirurgie (1)
- Adrenocortial carcinomas (1)
- Adrenocortical Cancer (1)
- Adrenocortical carcinoma (1)
- Adulte Stammzelle (1)
- Advanced Adrenocortical Carcinoma (1)
- African-americans (1)
- Agalsidase (1)
- Agalsidase beta (1)
- Aktionspotenzial (1)
- Akutes ischämisches Nierenversagen (1)
- Akzeptanz (1)
- Albumin (1)
- Aldosteron Antagonisten (1)
- Aldosteronantagonist (1)
- Aldosterone (1)
- Aldosterone Antagonists (1)
- Aldosteronism (1)
- Aldosteronismus (1)
- Aldosteronsynthase-Inhibitor (1)
- Allelische Verlustanalyse (1)
- Alpha-Galactosidase (1)
- Alpha-galactosidase (1)
- Altern (1)
- Alternans (1)
- Alveolarmakrophagen (1)
- Alzheimer’s dementia (1)
- Amino acids (1)
- Amyloidose (1)
- Anaplastic Thyroid Carcinoma (1)
- Anderson-Fabry Disease (1)
- Angiogenese (1)
- Angiotensin (1)
- Angst (1)
- Angststörung (1)
- Antibiotikum (1)
- Antigen (1)
- Antigen 4 (1)
- Antigen CD23 (1)
- Antikörper (1)
- Aortenklappe (1)
- Aortic arch (1)
- Aortic valve replacement (1)
- Aortokoronarer Bypass (1)
- Apherese (1)
- Aplastic anemia (1)
- ApoE-Knock-Out-Maus (1)
- ApoE-knock-out mice (1)
- ApoE/eNOS dko-Mäuse (1)
- Arginin (1)
- Arrhythmie (1)
- Arterial Stiffness (1)
- Arteriosclerosis (1)
- Artificial Nuclear Pores (1)
- AsP (1)
- Ataciguat (1)
- Atemvariabilität (1)
- Atorvastatins (1)
- Atrioventrikuläre Verzögerung (1)
- Aufmerksamkeit (1)
- Augenoberfläche (1)
- Ausdehnung (1)
- Autoimmun polyglanduläres Syndrom Typ 2 (1)
- Autoimmune-Diseases (1)
- Autophagie (1)
- Azetidinylamid (1)
- B (1)
- B cells (1)
- B-Zelle (1)
- BALF (1)
- BET Inhibitor (1)
- BIRC7 (1)
- BNP (1)
- BRAF mutation (1)
- BRAF(V600E) mutation (1)
- BRD4 (1)
- Basischarakteristika (1)
- Bayern (1)
- Befund (1)
- Behandlungswechsel von Agalsidase beta zu Agalsidase alfa (1)
- Belastungselektrokardiogramm (1)
- Berliner Blau (1)
- Beru (1)
- Bestimmung der hochgradigen Mitralklappeninsuffizienz (1)
- Bestrahlung (1)
- Betablocker (1)
- Betriebsmedizin (1)
- Bildgebung (1)
- Biochemical-Diagnosis (1)
- Bioimpedanz (1)
- Bioluminescence (1)
- Bisphosphonate (1)
- Blind Pericardiocentesis (1)
- Blinde Perikardiozentese (1)
- Blocking Peptide (1)
- Blockpeptid (1)
- Blut (1)
- Blutdruckmessung (1)
- Blutflussrate (1)
- Blutstammzelle (1)
- Blutzelle (1)
- Blutzuckerverlauf (1)
- Body-Mass-Index (1)
- Bodyplethysmographie (1)
- Bowditcheffekt (1)
- Brain atrophy (1)
- Brain natriuretic Peptide (1)
- Braune Fettzelle (1)
- Brownian ratchet (1)
- Brustaorta (1)
- C-C Chemokinrezeptor 7 (1)
- C-reaktives Protein (1)
- C3 (1)
- C57/Bl6 (1)
- CAR-T cell (1)
- CAR-T-Zell-Therapie (1)
- CASP (1)
- CCR2 (1)
- CD16 (1)
- CD23 (1)
- CD32 (1)
- CD4+ T-cells (1)
- CD68 (1)
- CD9 (1)
- CD95 (1)
- CHOP (1)
- CIED malfunction; pacemaker (PM) (1)
- CK-knockout Maus (1)
- CML (1)
- COH29 (1)
- COMT (1)
- COPD (1)
- COPD diagnosis (1)
- COVID‐19 vaccination (1)
- CRH stimulation test (1)
- CRISPR/Cas-Methode (1)
- CRP (1)
- CRP/crp (1)
- CRT (1)
- CT-scan (1)
- CTNNB1 (1)
- CX3CR1 (1)
- CYP11A1 (1)
- CYP2B6 (1)
- Ca cycling (1)
- Ca2+i handling (1)
- Calcineurin (1)
- Calcineurin-NFATsignaling (1)
- Calcium Citrate (1)
- Calcium-Aufnahme (1)
- Calibration (1)
- Cancer (1)
- Cancer genetics (1)
- Cannabionoid-1-Rezeptorantagonist (1)
- Carbonsäureamid (1)
- Carcinom (1)
- Cardiac Antigens (1)
- Cardiac magnetic resonance imaging (1)
- Cardiac resynchronization therapy defibrillator (1)
- CardioMEMS™ HF-System (1)
- Cardiomyopathy (1)
- Cardiovascular Riskfactors (1)
- Cardiovascular diseases (1)
- Cardiovascular hospitalizations (1)
- Cardiovascular risk factors (1)
- Cardiovascular risk prediction (1)
- Carotid intima-media thickness (CIMT) (1)
- Carotid segment (1)
- Carotid ultrasound (1)
- Caspase-3 (1)
- Caspase-8 (1)
- Catheter Lock Solution (1)
- Catheter-related Bloodstream Infections (CRBSI) (1)
- Cell (1)
- Cell lung canger (1)
- Chagas-Kardiomyopathie (1)
- Chagas-Krankheit (1)
- Chemokinrezeptoren (1)
- Chemokinrezpetor (1)
- Chirodiagnostik (1)
- Cholesterin (1)
- Cholesterin-Umtake (1)
- Cholesterinstoffwechsel (1)
- Cholesterol metabolism (1)
- Chromosom 8 (1)
- Chromosomenanalyse (1)
- Chronic Kidney-disease (1)
- Chronic heart failure (1)
- Chronic heart-failure (1)
- Chronic kidney-disease (1)
- Chronische Nierenerkrankung (1)
- Ciclosporin (1)
- Cine (1)
- Clinical prediction rule (1)
- Clinical proteomics (1)
- Clinical trial (1)
- Clinical-trials (1)
- Clodronsäure (1)
- Clopidogrel (1)
- Cognitive decline (1)
- Cohort study (1)
- Colonkrebs (1)
- Comorbidities (1)
- Complement (1)
- Computer-aided therapy (1)
- Computergestützte Medizin (1)
- Computertomografie (1)
- Congestiv Heart Failure (1)
- Contact-to-balloon (1)
- Contemplative Meditation and Breathing Techniques (CMBT) (1)
- Contrast agent (1)
- Contrast-enhanced CT (1)
- Copeptin (1)
- Coronavirus Disease 2019 (1)
- Cortisol (1)
- Cranial sutures (1)
- Cumulative incidence function (1)
- Cushing (1)
- Cushing syndrome (1)
- Cushing's (1)
- Cushing's disease (1)
- Cushings syndrome (1)
- Cyclo-GMP (1)
- Cystatin C (1)
- Cytokine (1)
- Cytoskeleton (1)
- D313Y genotype (1)
- DCAF17 (1)
- DCM (1)
- DF-Testung (1)
- DFT (1)
- DHEA-Sulfotransferase (1)
- DIA-MS (1)
- DISC (1)
- DNA damage (1)
- DNS-Gyrase (1)
- DOTATOC (1)
- DSC2 (1)
- DSG2 (1)
- Deceased Donor Score (1)
- Demenz (1)
- Dendritic Cells (1)
- Dephasing (1)
- Depression treatment (1)
- Depressive symptomatology (1)
- Derivate (1)
- Desmoplakin (1)
- Deutsches Zentrum für Herzinsuffizienz Würzburg (1)
- Deutschland (1)
- Deutschland / Bundeswehr (1)
- Diabetes mellitus Typ 1 (1)
- Diabetes mellitus Typ 2 (1)
- Diabetes mellitusTyp 1 (1)
- Diabetes melltius (1)
- Diabetic nephropathies (1)
- Diabetic-nephropathy (1)
- Diabetische Nephropathie (1)
- Diagnosis (1)
- Diagnostik / Bildgebendes Verfahren (1)
- Dialysatorleistung (1)
- Dialysemembran (1)
- Diastocic Dysfunction (1)
- Dickdarmkrebs (1)
- Dickenmessung (1)
- Differenzierung (1)
- Dihydroethidium (1)
- Dilated Cardiomyopathy (1)
- Dimension 3 (1)
- Dimethylarginin <N (1)
- Dipeptidyl-peptidase IV inhibitors (1)
- Diphosphonate (1)
- Discovery (1)
- Disease prevalence (1)
- Diversity (1)
- Dobutamin-Stress-Echokardiographie (1)
- Dokumentationsqualität (1)
- Donor-Score (1)
- Doppelfiltrationsplasmapherese (1)
- Dosierungen von Herzinsuffizienzmedikamenten (1)
- Draisine <Zweirad> (1)
- Dravet Syndrom (1)
- Drogen (1)
- Drotrecogin alpha (1)
- Drug-eluting Stent (1)
- Drugs (1)
- Dumping Syndrom (1)
- Dumping-Syndrome (1)
- E/e’ (1)
- E193 (1)
- ECG-gated (1)
- EMT (1)
- EP Procedures (1)
- EPC (1)
- EPU (1)
- EQUAL-Pilotstudie (1)
- ERCC1 (1)
- ERCC1 Chemotherapie Nebennierenrindenkarzinom (1)
- ERI (1)
- ESC (1)
- ESC Score (1)
- ETB-Rezeptor (1)
- ETB-receptor (1)
- EUROASPIRE (1)
- EUROASPIRE survey (1)
- Echtes WRF (1)
- Einflussfaktoren (1)
- Elastin (1)
- Elastizität (1)
- Elektrokardiografie (1)
- Elektrophysiologie (1)
- Elektrostimulation (1)
- Embolie (1)
- Embryos (1)
- Empathie (1)
- End-of-Life Care (1)
- End-of-Life Decision (1)
- Enddiastolisches Volumen (1)
- Endocannabinoide (1)
- Endocrinology (1)
- Endogenes Erythropoietin und Mortalität (1)
- Endogenous erythropoietin and all-cause mortality (1)
- Endokrine Onkologie (1)
- Endokrinopathie (1)
- Endothelaktivierung (1)
- Endotheldysfunction (1)
- Endothelin (1)
- Endothelzelle (1)
- Enhancer elements (1)
- Entscheidungsunterstützungssystem (1)
- Enzym-Ersatz-Therapie (1)
- Enzyme-linked immunosorbent assay (1)
- Enzymersatztherapie bei Morbus Fabry (1)
- Enzyminhibitor (1)
- Enzyminhibitoren (1)
- Epidemiology (1)
- Eplerenon (1)
- Epoetin beta (1)
- Erblichkeit (1)
- Ereignisdatenanalyse (1)
- Ergospirometrie (1)
- Erlotinib (1)
- Ernährungs- und Bewegungstherapie (1)
- Ersatzstoff (1)
- Erwartungshaltung (1)
- Etiology (1)
- Etomidat (1)
- European Society (1)
- Euroscore (1)
- Evaluation (1)
- Exchange Stabilization Fund (1)
- Expression (1)
- Extracellular volume (1)
- Extracorporeal membrane oxygenation (1)
- Extrakorporale Dialyse (1)
- Eya4 (1)
- Ezetimibe (1)
- F-18-FDG PET/CT (1)
- FACS (1)
- FACS-Flow-Analysen (1)
- FAMI (1)
- FAP alpha (1)
- FGF21 (1)
- FGFR-inhibitors (1)
- Fabry Disease (FD) (1)
- Fabry Kardiomyopathie (1)
- Fabry Stabilization Index (1)
- Fabry cardiomyopathy (1)
- Fabry patient (1)
- Fabry's disease (1)
- Fabry-Kardiomyopathie (1)
- Fabry-Nephropathie (1)
- Fabry-associated pain (1)
- False positive reactions (1)
- Family Investigation of Nephropathy and Diabetes (1)
- Fas-Ligand (1)
- Fehlerverhütung (1)
- Felddetektion (1)
- Female patients (1)
- Femoralarterienplaque (1)
- Femoralplaque (1)
- Fettgewebe (1)
- Fettmassenanteil (1)
- Fettzelle (1)
- Fetuin-A (1)
- FiTT-STEMI (1)
- Fibroblast Growth Factor-21 (1)
- Fibroblast-Growth-Factor-23 (1)
- Fibroblastenwachstumsfaktor (1)
- Fibronectin (1)
- Fibrozyt (1)
- Fliegendes Personal (1)
- Fliegerarzt (1)
- Fluorescence in situ hybridization (1)
- Fluoreszenz-in-situ-Hybridisierung (1)
- Fontan’s Operation (1)
- Force-frequency relation (1)
- FoxP3 Expression (1)
- Foxp3 (1)
- Foxp3+CD4+ regulatorische T-Zelle (1)
- Fractalkine (1)
- Fraktionierungsmembran (1)
- Framingham (1)
- Freie Fettsäuren (1)
- Frequenzüberstimulation (1)
- Friedreich-Ataxie (1)
- G protein coupled receptors (1)
- GFR (1)
- GH response (1)
- GLA protein UCMGP (1)
- GLP-1 (1)
- GMPcGMP-dependent protein kinase I (1)
- GOLD (1)
- GP IIb/IIIa Rezeptor-Antagonist (1)
- GP IIb/IIIa inhibitor (1)
- GRAPPA (1)
- Galactosidase-A gene (1)
- Game (1)
- Gastric-banding (1)
- Gb3 and lyso-Gb3 biomarkers (1)
- Gefäßsteifigkeit (1)
- Gemcitabin (1)
- General-population (1)
- Genexpression (1)
- Genome-wide association studies (1)
- Genregulation (1)
- Geriatrie (1)
- Gering differenziertes Schilddrüsenkarzinom (1)
- Geschlechtsunterschied (1)
- Glial fibrillary acidic protein (1)
- Globotriaosylceramide (1)
- Glomerular-filtration-rate (1)
- Glucocorticosteroide (1)
- Gluconeogenese (1)
- Gluconeogenesis (1)
- Glucosephosphatdehydrogenase (1)
- Glucosestoffwechsel (1)
- Glukoseaufnahme (1)
- Glukoseeffektivität (1)
- Glukosestoffwechsel (1)
- Glut4 (1)
- Glutathion (1)
- Glycaemic control (1)
- Graves disease (1)
- Großtiermodell (1)
- Grundlagenforschung (1)
- Guanylyl cyclase (1)
- HAT (1)
- HCM (1)
- HD (1)
- HDF (1)
- HEK cells (1)
- HFpEF (1)
- HIV (1)
- HIV diagnosis and management (1)
- HLA (1)
- HMR1766 (1)
- HMW-Adiponektin (1)
- HPLC (1)
- HPLC-MS (1)
- HSD3B2 (1)
- HUVEC (1)
- HUVEC Zellen (1)
- Haemodialysis (1)
- Hausarzt (1)
- Haut (1)
- Hazards (1)
- Healthcare research (1)
- Heart (1)
- Heart attack (1)
- Heart failure with preserved ejection fraction (1)
- Heart failure with reduced ejection fraction (1)
- Heeresfliegertruppe (1)
- Hematopoietic cell transplant (1)
- Hemodialysis-patients (1)
- Hemoglobin A1C (1)
- Hepcidin (1)
- Herz (1)
- Herzbeutel (1)
- Herzerkrankung (1)
- Herzerweiterung (1)
- Herzfunktion (1)
- Herzklappenfehler (1)
- Herzmuskelzelle (1)
- Herzrhythmusstörung (1)
- Herzrhythmusstörungen (1)
- HiGHmed (1)
- High risk prostate cancer (1)
- Hindbrain (1)
- Hippocampus (1)
- Hochrisiko Prostatakarzinom (1)
- Home monitoring (1)
- Homoarginin/homoarginine (1)
- Homoarginine (1)
- Hormon (1)
- Hubschrauber (1)
- Hubschrauberpilot (1)
- Humangenetik (1)
- Hydroxysteroid-Sulfotransferase (1)
- Hyperandrogenämie (1)
- Hypercholesterinämie (1)
- Hypercortisolism (1)
- Hyperglykämie (1)
- Hyperkalemia (1)
- Hyperosmotic Stress (1)
- Hyperoxidion (1)
- Hyperoxidion Dihydroethidine (1)
- Hypertrophische Herzmuskelkrankheit (1)
- Hypoadrenalismus (1)
- Hypoglycemia (1)
- Hypoglykämie (1)
- Hypoparathyreoidismus (1)
- Hämodynamik (1)
- ICD-coding of CKD (1)
- IDH1/2 (1)
- IGF-1 (1)
- IGF-I (1)
- IMAZA (1)
- IP3 (1)
- IP3-Signaling (1)
- IP3-sponge (1)
- Idiopathische pulmonale Fibrose (1)
- Immun-Checkpoint (1)
- Immunassay (1)
- Immuncheckpointinhibitor (1)
- Immuncytochemie (1)
- Immune-System (1)
- Immuninfiltration (1)
- Immunoassay (1)
- Immunohistochemistry (1)
- Immunological Self-Tolerance (1)
- Immunseneszenz (1)
- Immunsystem (1)
- Impella (1)
- Implantierbare Kardioverter Defibrillatoren (1)
- Index-Hospitalisierung (1)
- Indoxylsulfat (1)
- Infarkt (1)
- Infarktausdehnung (1)
- Infarktdicke (1)
- Infarktvolumen (1)
- Infection control (1)
- Inflammationsmarker (1)
- Inhibition (1)
- Inositoltrisphosphat (1)
- Instant (1)
- Insulin therapy (1)
- Insulin-like Growth Factor I (1)
- Intensive Care (1)
- Intensivmedizin (1)
- Intensivtransport (1)
- Interhospitaltransfer (1)
- Interkonversion (1)
- Interleukin-6 (1)
- Interviews (1)
- Iodmetomidat (1)
- Ionenkanal (1)
- Ionenkanalopathie (1)
- Ionic strength (1)
- Ionisierende Strahlung (1)
- Ischämie-Reperfusion (1)
- JQ1 (1)
- Jugendliche (1)
- Juvenile biventricular cardiomyopathy (1)
- KWIC (1)
- Kalzifikation (1)
- Kammerflimmern (1)
- Kaposi sarcoma (1)
- Kardiale Dekompensation (1)
- Kardiale Phasenkontrast-MRT (1)
- Kardiale Resynchronisationstherapie (1)
- Kardinale Antigene (1)
- Kardio-CT (1)
- Kardio-MRT (1)
- Kardiomyozyt (1)
- Kardiomyozyten (1)
- Kardiovaskuläre Krankheit (1)
- Kardiovaskuläres System / Krankheit (1)
- Karotisarterienplaque (1)
- Karotisplaque (1)
- Kathetersepsis (1)
- Katheterthrombose (1)
- Kernspinrelaxation (1)
- Kernspinresonanz (1)
- Kinder (1)
- Kinetik der Sauerstoffaufnahme (1)
- Kleinzelliges Bronchialkarzinom (1)
- Klinische Symptomatik (1)
- Klinisches Experiment (1)
- Klotho-related molecules (1)
- Knochenmarkzelle (1)
- Knochenmetastasen (1)
- Knock-Out <Druckschrift> (1)
- Knockdown (1)
- Kohortenstudie (1)
- Kollagendefekt (1)
- Kolon (1)
- Kolonkarzinogenese (1)
- Kombination EKG-Kriterien (1)
- Komorbiditäten (1)
- Komorbiditäten bei Nebenniereninsuffizienz (1)
- Komplement (1)
- Komplikationen (1)
- Kondensation (1)
- Kontraktilität (1)
- Kontrollierte klinische Studie (1)
- Koronararterie (1)
- Koronarographie (1)
- Kosten (1)
- Kraniopharyngiom (1)
- Krankheit (1)
- Kreatinin (1)
- Kreatinkinase (1)
- Krebs (1)
- Kreuzschmerz (1)
- Körperliche Leistungsfähigkeit (1)
- L-Arginin Paradox (1)
- L-arginine (1)
- LC/MS (1)
- LCA (1)
- LCNEC (1)
- LDL (1)
- LDL cholesterol (1)
- LMNA (1)
- LND (1)
- LNE (1)
- LOH (1)
- LV dilatation (1)
- LV mass (1)
- LVNC (1)
- Lag time (1)
- Langfristige Prognose (1)
- Langzeit-Elektrokardiogramm (1)
- Langzeit-Follow-up (1)
- Langzeitbeatmung (1)
- Langzeitprognose (1)
- Langzeitüberleben (1)
- Late Enhancement (1)
- Lebensqualitaet (1)
- Lebensqualitätsfragebögen (1)
- Lebensstilintervention (1)
- Leber (1)
- Left ventricular function (1)
- Left ventricular hypertrophy (1)
- Lehre (1)
- Leitliniengerechte Therapie (1)
- Leptine (1)
- Leukozyt (1)
- Leukozyten-Endothelzell-Interaktionen (1)
- Linagliptin (1)
- Line of Perpendicularity (1)
- Linke Herzkammer (1)
- Linksherzstimulation (1)
- Linksschenkelblock (1)
- Linksventrikuläre Funktion (1)
- Linksventrikuläre Hypertrophie (1)
- Linksventrikuläre Masse (1)
- Linksventrikuläre systolische Funktion (1)
- Lipolyse (1)
- Lipoprotein (1)
- Lipoprotein Lp (a) (1)
- Lipoproteinapherese (1)
- Lipoxygenase <5-> (1)
- Long COVID (1)
- Loop recorder (1)
- Loss of heterozygosity (1)
- Low-Gradient Aortenklappenstenose (1)
- Lungenfibroblasten (1)
- Lungenfunktionsdiagnostik (1)
- Lungenfunktionsprüfung (1)
- Lycopin (1)
- Lymphoceles (1)
- Lymphozelen (1)
- Lyso Gb3 (1)
- Lyso-GB3 (1)
- MAPSE (1)
- MASS (1)
- MCP-1 (1)
- MEN1 (1)
- MMP (1)
- MMP-9 (1)
- MOLLI (1)
- MR (1)
- MR guidance (1)
- MRP-1 (1)
- MTC (1)
- MTL30 (1)
- MTUS1-Gen (1)
- MUST-Score (1)
- MUTYH1 (1)
- Macrophages (1)
- Magnetic Resonance Imaging (1)
- Magnetic resonance imaging (1)
- Magnetische Resonanz (1)
- Makroalbuminuriker (1)
- Makrophage (1)
- Mangelernährung (1)
- Markumar (1)
- Mass-spectrometry (1)
- Matrix-Gla-Protein (1)
- Maus <Gattung> (1)
- Maus-Lungen-Fibroblasten (1)
- Measurement (1)
- Medulläres Schilddrüsenkarzinom (1)
- Membranöse Glomerulonephritis (1)
- Memory dysfunction (1)
- Men (1)
- Mensch (1)
- Metabolisches Syndrom (1)
- Metabolismus (1)
- Metabolom (1)
- Metabolome (1)
- Metabolomics (1)
- Metabolomik (1)
- Metanephrin (1)
- Metanephrine (1)
- Methicillin-resistant staphylococcus aureus (1)
- Methodological quality (1)
- Metomidat (1)
- Metoprolol (1)
- Metoprolol Tartrat (1)
- Mfn2 KO mice (1)
- Mice (1)
- Mikroarray (1)
- Mikrozirkulation (1)
- Mineralkortikoidrezeptor-Blockade (1)
- Mitochondrien (1)
- Mitochondrium (1)
- Mitofusin2 (1)
- Mitose (1)
- Mitotane Nebennierenkarzinom (1)
- Mitraclip (1)
- Mitral regurgitation (1)
- Mitralklappe (1)
- Mitralklappenfehler (1)
- Mitralklappeninsuffizienz (1)
- Mitralklappenringbewegung (1)
- Mitralklappenvitium (1)
- Mittelgradige Aortenklappenstenose (1)
- Mobilitet (1)
- Mobility (1)
- Model (1)
- Molecular Channel Transport (1)
- Molekül (1)
- Monocytes (1)
- Monozyt (1)
- Monozyten (1)
- Monozyten-Makrophagen-System (1)
- Morbidity (1)
- Morbidität (1)
- Morbus Cushing (1)
- Mortalität (1)
- Motorisches Gleichgewicht (1)
- Mouse (1)
- Mouse models (1)
- Multidrug Resistance Protein-1 (1)
- Multiparameter predictor (1)
- Multiple-Sclerosis (1)
- Multiples Myelom (1)
- Muscle (1)
- Muskel (1)
- Muskelfasertypen (1)
- Mutation (1)
- Mycardiale Heilung (1)
- Mycophenolate mofetil (1)
- Mycophenolatmofetil (1)
- Myeloma (1)
- Myocardial Healing (1)
- Myocardial Hypertrophy (1)
- Myocardial Infarction (1)
- Myocardial ischemia (1)
- Myocardial-Infarction (1)
- Myocardium (1)
- Myokard (1)
- Myokardiale T1ρ-Quantifizierung (1)
- Myokardiales Remodeling (1)
- Myokardifarktmodell (1)
- Myosin (1)
- Myosin-Schwerkette (1)
- N-> (1)
- NASH (1)
- NCI-H295 Zellen (1)
- NCI-H295R (1)
- NEC (1)
- NET (1)
- NMR-Tomography (1)
- NMR-tomography (1)
- NO-Bioverfügbarkeit (1)
- NO-Synthase (1)
- NO/cGMP pathway (1)
- NO/cGMP-Signalkaskade (1)
- NOP10 (1)
- NOX (1)
- NR3C1 (1)
- NSG animals (1)
- Nahrung (1)
- Natrium-23 (1)
- Natriumkonsum (1)
- Natriuretisches Hormon (1)
- Natural-history data (1)
- Nav1.1 Kanal (1)
- Navigation (1)
- Nebenenniereninsuffizienz (1)
- Nebennierenerkrankung (1)
- Nebennierengewebe (1)
- Nebenniereninzidentalom (1)
- Nebennierenkrankheit (1)
- Nebennierenkrisen Addison Krise (1)
- Nebennierenvenenkatheter (1)
- Nebenwirkungen (1)
- Neoplasma (1)
- Nephropathie (1)
- Nephrotisches Syndrom (1)
- Neprilysin inhibition (1)
- Network (1)
- Netzwerk (1)
- Neurohormone (1)
- Neurokognitive Funktion (1)
- New mexico (1)
- NfL (1)
- Nicht-kleinzelliges Bronchialkarzinom (1)
- Niedergelassene Kardiologen (1)
- Nitric oxide (1)
- Nitric oxide synthase (1)
- Non-Compaction Kardiomyopathie (1)
- Non‐ischaemic cardiogenic shock (1)
- Normetanephrin (1)
- Normetanephrine (1)
- Normierung (1)
- Notfall (1)
- Nrf2 (1)
- OAT1 (1)
- OAT3 (1)
- OK cells (1)
- ORO (1)
- OSI (1)
- OXPHOS (1)
- Obesity (1)
- Observational study (1)
- Obstruktive Ventilationsstörung (1)
- Oil-Red-O (1)
- Onkologie (1)
- Onset hypertrophic cardiomyopathy (1)
- Oral antidiabetic drugs (1)
- Organversagen (1)
- Oscillation of QT interval (1)
- Osteogenesis imperfecta (1)
- Oszillationen der QT-Zeit (1)
- Outcome survey (1)
- Outcomes (1)
- OxLDL (1)
- P-cresyl sulfate (1)
- P2Y12-Rezeptor (1)
- P2Y12-receptor (1)
- P450scc (1)
- PAPSS2 (1)
- PBMC (1)
- PCI (1)
- PCR (1)
- PF-05231023 (1)
- PHQ-2 (1)
- PLC (1)
- PPGL (1)
- PRO (1)
- PTA (1)
- PWV (1)
- PYY3-36 (1)
- Pain (1)
- Pain-related evoked potentials (1)
- Palmitinsäure (1)
- Palmoplantar keratoderma (1)
- Pankreatisches Polypeptid (1)
- Paragangliom (1)
- Paraganglioma (1)
- Parathormon (1)
- Paricalcitol (1)
- Pathogener Mikroorganismus (1)
- Patientencharakteristika (1)
- Patientenperspektiven (1)
- Patientenschulung (1)
- Patientenschulungen (1)
- Patientenzufriedenheit (1)
- Pax-5 (1)
- Pedometer (1)
- Pentaerythrityltetranitrat (1)
- Performance (1)
- Pericardium (1)
- Perikard (1)
- Perikarderguss (1)
- Perikardiozentese (1)
- Perikardpunktion (1)
- Perikardtamponade (1)
- Perkutane transluminale koronare Angioplastie (1)
- Perspektivenübernahme (1)
- Perspektivwechsel (1)
- Phosphoadenosinphosphosulfat (1)
- Phosphoantigene (1)
- Phosphodiesterasehemmer (1)
- Physical impairment (1)
- Physiologie (1)
- Plaque (1)
- Plasma (1)
- Plasmametanephrine (1)
- Plasmapherese (1)
- Platin (1)
- Plötzlicher Herztod (1)
- Polymerase-Kettenreaktion (1)
- Popdc (1)
- Positron-emission-tomography (1)
- Postischämiesyndrom (1)
- Postmarketing Experience (1)
- Postoperative Hypoglykämie (1)
- Predictive value of tests (1)
- Predictors (1)
- Preserved Ejection Fraction (1)
- Primary care (1)
- Primärer Hyperaldosteronismus (1)
- Probabilities (1)
- Prognose Nebennierenrindenkarzinom (1)
- Prognosefaktoren (1)
- Prognostic Factors ACC (1)
- Prognostic impact (1)
- Progression (1)
- Progressionsverzögerung (1)
- Prokollagen (1)
- Proliferation (1)
- Promotor <Genetik> (1)
- Promotor Regulation (1)
- Pronosefaktoren Nebennierentumor (1)
- Prostaglandin E2 (1)
- Prostaglandin E2-Ausscheidung (1)
- Protein (1)
- Protein C (1)
- Protein p8 (1)
- Protein-Tyrosin-Kinasen (1)
- Proteinbindung (1)
- Proteinmangel (1)
- Proteinurie (1)
- Prussian Blue (1)
- Prädilutions-Hämodiafiltration (1)
- Prävalenz (1)
- Pseudo-WRF (1)
- Psychopharmakologie (1)
- Psychotherapie (1)
- Pulmonologie (1)
- Pulswelle (1)
- QT intervall dispersion (1)
- QT-Dispersion (1)
- QT-Zeit Verlängerung (1)
- Qualitative Content Analysis (1)
- Qualitative Inhaltsanalyse (1)
- RAKI (1)
- RANTES (1)
- RCA (1)
- RNA Expression (1)
- RNAScope (1)
- RNR (1)
- ROCK-1 (1)
- ROR2 (1)
- RRM1 (1)
- RRM2 (1)
- Racial differences (1)
- Radiation (1)
- Radiochemotherapie (1)
- Radiochirurgie (1)
- Radioiodtherapie (1)
- Raman micro-spectroscopy (1)
- Ramipril (1)
- Rat (1)
- Reactive Oxygen Species (1)
- Reaktive Sauerstoffspezies (1)
- Rebreathing (1)
- Rechtsventrikuläre Thrombusbildung (1)
- Recognition of depression (1)
- Recovery (1)
- Redox-Stoffwechsel (1)
- Reduktion der Mortalität (1)
- Referenzperzentile (1)
- Register (1)
- Registry (1)
- Regression (1)
- Regulatorische T-Lymphozyt (1)
- Regulatorischer T-Lymphozyt (1)
- Rekrutierung (1)
- Rekrutierungsstrategien (1)
- Remote device monitoring (1)
- Renin-Angiotensin-Aldosteron System (1)
- Renin-Angiotensin-System (1)
- Renin-angiotensin System (1)
- Reoperation (1)
- Research design (1)
- Resistance (1)
- Rezeptorblocker (1)
- Rezidiv (1)
- Rheumatischer Formenkreis (1)
- Rheumatismus (1)
- Rho-kinase (1)
- Right ventricular dysfunction (1)
- Ringmotion (1)
- Risikoprädiktion (1)
- Risikostratifizierung (1)
- Risk (1)
- Risk-factors (1)
- Rosiglitazon (1)
- Rosuvastatin (1)
- Rotary EXcitation (REX) (1)
- Rotary Excitation (1)
- Roux-en-Y Gastric Bypass (1)
- Rückatmungsmethode (1)
- Rückenschmerz (1)
- SARS‐CoV‐2 infection (1)
- SASHA (1)
- SB 239063 (1)
- SBRT (1)
- SCD-Risko nach PTSMA (1)
- SCORE (1)
- SDMA/SDMA (1)
- SF-36 Health survey (1)
- SF-36 questionnaire (1)
- SG (1)
- SGLT2 inhibitor (1)
- SMEI (1)
- SNP (1)
- SOAT (1)
- SOAT Inhibitoren (1)
- SR Ca leak (1)
- SR/Mitochondriales Feedback (1)
- SR/mitochondria metabolic feedback (1)
- SREBP-2 (1)
- SSTR (1)
- ST-elevation myocardial infarction (1)
- STEMI (1)
- STIM2 (1)
- SUDEP (1)
- SULT2A1 (1)
- SUMO2 (1)
- Salz (1)
- Sample-sizes (1)
- Sarcoidosis (1)
- Sarkomer (1)
- Sars-CoV-2 (1)
- Sauerstoffaufnahme (1)
- Schaf (1)
- Schenkelblock (1)
- Schilddrüse (1)
- Schlaganfall (1)
- Schlauchmagen (1)
- Schockeffektivität (1)
- Schocktestung (1)
- Schold-Score (1)
- Schrittzähler (1)
- Schulungsprogramm (1)
- Schwanmessmethode (1)
- Sechs-Minuten-Gehstrecke (1)
- Sekundenherztod (1)
- Sekundäre Hypertonie (1)
- Sekundärkrankheit (1)
- Sekundärneoplasie (1)
- Sekundärtumor (1)
- Selbsterfahrung (1)
- Selektivität (1)
- Self-navigation (1)
- Seltene Krankheit (1)
- Septischer Schock (1)
- Septumwulst (1)
- Serinproteinasen (1)
- Severe Acute Respiratory Syndrome Coronavirus 2 (1)
- Sex-Hormones (1)
- ShMOLLI (1)
- Sham (1)
- Short-term-Variabilität (1)
- Sildenafil (1)
- Simulator (1)
- Simvastatin (1)
- Skeletal-related events (1)
- Skin (1)
- Skull (1)
- Slow Component der Sauerstoffaufnahme (1)
- Small fiber neuropathy (1)
- Society (1)
- Sodiumchannel (1)
- Somatische Mutation (1)
- Somites (1)
- Speckle Tracking (1)
- Speckle tracking (1)
- Spin echo (1)
- Spin-Lock (1)
- Spirituell-ganzheitliche Behandlung (1)
- Spiroergometrie (1)
- Sport (1)
- Sportart (1)
- Sportliche Bewegung (1)
- Stage renal-disease (1)
- Statine (1)
- Stein-Leventhal-Syndrom (1)
- Stemi (1)
- Stent (1)
- Stereotaktische Strahlentherapie (1)
- Steroidhormon (1)
- Steroidogenese (1)
- Steroidstoffwechsel (1)
- Sterol O-Acyltransferasen (1)
- Sterol-O-Acyl transferases (1)
- Sterol-O-Acyl-Transferase (1)
- Stickstoffmonoxid Synthase (1)
- Stickstoffoxidsynthase (1)
- Stiffness (1)
- Strahlenbelastung (1)
- Strahlenfibrose (1)
- Strain (1)
- Strain Rate Imaging (1)
- Strain-Rate (1)
- Subdistribution (1)
- Subjektive Krankheitswahrnehmung (1)
- Sudden cardiac death (1)
- Sudden death (1)
- Sudden death Risk after PTSMA (1)
- Sunitinib (1)
- Superoxidanion (1)
- Superoxidanionen (1)
- Superparamagnetische Eisenoxid Kontrastmittel (1)
- Suppressive Function (1)
- Surrogat (1)
- Survival (1)
- Survival Study (1)
- Survival analysis (1)
- Symptom (1)
- Symptome (1)
- Systemic-Lupus-Erythematosus (1)
- Systole (1)
- T lymphocytes (1)
- T-Cell Specificity (1)
- T-Lymphocytes (1)
- T-Zell Spezifität (1)
- T-Zellen (1)
- T-cells (1)
- T1 mapping (1)
- TERT (1)
- TGF beta (1)
- TGF-beta antibody (1)
- THP-1- cells (1)
- THP-1-Zellen (1)
- TIMP (1)
- TIMP-1 (1)
- TIP39 (1)
- TRAIL (1)
- TRB3 (1)
- TTE (1)
- TT\(_{1rho}\) mapping (1)
- TVI (1)
- T\(_{1P}\) dispersion (1)
- T\(_{1P}\) mapping (1)
- Tanzania (1)
- Taurolidine (1)
- Teichholz formula (1)
- Teicholz-Formel (1)
- Telemetrie (1)
- Test accuracy (1)
- Testosteronreductase <Testosteron-5-alpha-Reductase> (1)
- Testosteronstoffwechsel (1)
- Tests (1)
- Thalidomid (1)
- The L-arginine Paradox (1)
- Therapieadhärenz (1)
- Therapiebegrenzung (1)
- Therapiezieländerung (1)
- Thermodynamics (1)
- Thermodynamik (1)
- Thrombi (1)
- Thrombozyten (1)
- Thrombozyten-Aktivierung (1)
- Thrombus (1)
- Thymus (1)
- Time measurement (1)
- Time-motion-Ultraschallkardiographie (1)
- Tirofiban (1)
- Titre-Course (1)
- Topoisomerase I (1)
- Topoisomerase II (1)
- Topoisomerase II alpha (1)
- Topoisomerases I (1)
- Toxin (1)
- Transforming Growth Factor beta 1 (1)
- Transkription <Genetik> (1)
- Transplantatfunktion (1)
- Transport (1)
- Transporthubschrauberregiment 30 (1)
- Treatment outcome (1)
- Treatment switch in fabry disease (1)
- Treg (1)
- Tregs (regulatory T cells) (1)
- Treppenphänomen (1)
- Tumorsuppressor-Gen (1)
- Tumorsuppressorgen (1)
- Tumosuppresorgen (1)
- Typ 2-Diabetes (1)
- Typ-1-Diabetes (1)
- Typ-2-Diabetes-mellitus (1)
- Tyrosinkinase (1)
- USP28 (1)
- USP48 (1)
- Ultrahochfeldmagnetresonanztomographie (1)
- Ultraschall (1)
- Ultraschallgeführte Biopsie (1)
- Ultraschallgesteuert (1)
- Ultraschallkar (1)
- Ultraschallkardiografie (1)
- Utility (1)
- VAS (1)
- VCAM (1)
- VEMP (1)
- VYOO VYOO-PCR (1)
- Valvular heart-desease (1)
- Vapreda (1)
- Variants (1)
- Vaskuläre Funktion (1)
- Vasokonstriktion (1)
- Vasoreaktivitäsmessung (1)
- Ventricular Remodeling (1)
- Ventricular septal rupture (1)
- Ventrikelruptur (1)
- Ventrikuläres Remodeling (1)
- Verdachtsüberprüfung (1)
- Verhalten (1)
- Verlaufsbeobachtung (1)
- Verringerung (1)
- Verträglichkeit der Enzymersatztherapie (1)
- Virtual-Reality (1)
- Virtual-reality (1)
- Virtuelle Realitaet (1)
- Virtuelle Realität (1)
- Vitamin-D-Mangel (1)
- Volumenmessung (1)
- Vorderwandinfarkt (1)
- Vordilatation (1)
- Vorhofkatheter (1)
- Wachstumshormonbehandlung (1)
- Wandschubspannung (1)
- Weaning (1)
- Weiße Fettzelle (1)
- Western Blot (1)
- Wistar-Ratte (1)
- Wistar-Ratten (1)
- Woodhouse-Sakati Syndrom (1)
- Woodhouse-Sakati sydrome (1)
- Workshop Neue Aspekte zur Linksventrikulären Dysfunktion (1992 : Erbach, Rheingau) (1)
- Wound Healing (1)
- Wundheilung (1)
- Wärmebildkamera (1)
- X-chromosomal inactivation (1)
- XA (1)
- Young-patients (1)
- ZDF rats (1)
- Zebrabärbling (1)
- Zebrafisch (1)
- Zebrafish (1)
- Zentrale Toleranz (1)
- Zetrales Cushing Syndrom (1)
- Zucker fatty fa/fa rats (1)
- Zwei-Hefen-Hybrid-System (1)
- Zweitlinientherapie (1)
- [11C]-Choline PET/CT (1)
- [11C]-Methionine (1)
- [177Lu]/[90Y]PentixaTher (1)
- [177Lu]PentixaTher (1)
- [18F]FDG-PET-CT (1)
- [90Y]PentixaTher (1)
- [99mTc]-Sestamibi scan (1)
- [\(^{68}\)Ga] pentixafor (1)
- \(^{18}\)F-FDG (1)
- \(^{18}\)F-fluorodeoxyglucose (1)
- abdominal lymph node metastases (1)
- absorption (1)
- accelerated atherosclerosis (1)
- activated protein C (1)
- activated-receptor gamma (1)
- activation (1)
- acute (1)
- acute respiratory distress syndrome (1)
- adaptive immune response (1)
- add-on (1)
- adenovirus (1)
- adenoviruses (1)
- adenylyl cyclase signaling cascade (1)
- adherence (1)
- adiponectin (1)
- adjuvant platinum-based chemotherapy (1)
- adjuvant therapy (1)
- adjuvant treatment (1)
- adrenal cancer (1)
- adrenal cortex hormones (1)
- adrenal cortex neoplasms (1)
- adrenal cortical carcinoma (1)
- adrenal gland (1)
- adrenal glands (1)
- adrenal imaging (1)
- adrenal incidentaloma (1)
- adrenal surgery (1)
- adrenal tumor (1)
- adrenal tumors (1)
- adrenale Steroidogenese (1)
- adrenalectomia (1)
- adrenocortical (1)
- adrenocortical adenocarcinoma (1)
- adrenocortical carcinoma (ACC) (1)
- adrenocortical cell line (1)
- adrenocortical development (1)
- adrenocortical tissues (1)
- adrenocortical tumor (1)
- adrenokortikale Zellen (1)
- adrenokortikales Karzinom (1)
- adult patients (1)
- adverse effects (1)
- afatinib (1)
- agalsidase-beta (1)
- agnoists (1)
- aircrew (1)
- akute Niereninsuffizienz (1)
- akutes Koronarsyndrom (1)
- akutes Nierenversagen (1)
- albumin (1)
- albumin excretion rate (1)
- albuminuria (1)
- alcohol (1)
- aldostoreone synthase inhibitor (1)
- alkaline phosphatase (1)
- allocation (1)
- allogeneic hematopoietic stem cell transplantation (1)
- alpha -Galaktosidase (1)
- alpha galactosidase (1)
- alpha- Galactosidase (1)
- alpha-galactosidase-A (1)
- alpha/delta agonist GFT505 (1)
- amphiphilic block copolymer (1)
- anaemia (1)
- anatomy (1)
- animal model (1)
- animal models of human disease (1)
- antagonist (1)
- anti-drug antibodies (1)
- anti-myocardial (1)
- antibiotic prescription (1)
- anticoagulation (1)
- antidiabetic agents (1)
- antimicrobial stewardship (1)
- antiphospholipid syndrome (1)
- antiretroviral therapy (1)
- antiretrovirals (1)
- anti‐SARS‐CoV‐2‐spike IgG (1)
- aorta (1)
- aortic stenosis (1)
- aortic valve (1)
- aortic valve disease (1)
- aortic valve disease percutaneous intervention (AVDP) (1)
- aortic valve stenosis (1)
- aortic valve stenosis (AS) (1)
- apoE-Knockout Maus (1)
- apoE-knockout mouse (1)
- apolipoprotein E (1)
- apolipoprotein-E (1)
- apoptosis (1)
- arial fibrillation (1)
- arrhythmogenic cardiomyopathy (1)
- arterial elasticity (1)
- arterial stiffening (1)
- arterielle Hypertonie (1)
- astrocytoma (1)
- asymmetric dimethylarginine (1)
- asymmetrisches Dimethylarginin (1)
- at-home sampling (1)
- atheriosclerosis (1)
- atherogenic dyslipidaemia (1)
- atherosclerosis risk (1)
- atrial fibrillation (1)
- atrioventricular delay (1)
- atypical (1)
- autoantibodies (1)
- autoantibody (1)
- autoimmune polyglandular syndrome type 2 (1)
- autonome Imbalance (1)
- autonomous cortisol secretion (1)
- autosomal recessive (1)
- avascular necrosis (1)
- awareness (1)
- back pain (1)
- balance (1)
- bardoxolone methyl (1)
- bariatrische Eingriffe (1)
- battery depletion (1)
- behavior (1)
- behavioral changes (1)
- benefit (1)
- beta blockers (1)
- beta-Carotin (1)
- beta-carotene (1)
- beta1-adrenerge Autoantikörper (1)
- beta1-adrenerger Rezeptor (1)
- beta1-adrenergic receptor (1)
- betriebliche Gesundheitsförderung (1)
- bioinformatic clustering (1)
- biomarker prediction (1)
- biopsy (1)
- biopsy findings (1)
- bisphosphonates (1)
- blood coagulation factor XIII (1)
- blood plasma (1)
- blood pressure monitoring (1)
- blood-glucose control (1)
- bloodflow (1)
- blood–brain barrier (1)
- bone formation (1)
- bone metabolism (1)
- bone mineral density (1)
- brain natriuretic peptide (1)
- brain pathology (1)
- branched-chain amino acids (1)
- bull’s eye plot (1)
- buparlisib (1)
- c-MYC (1)
- cAMP (1)
- calcineurin signaling cascade (1)
- calcium imaging (1)
- canagliflozin (1)
- cancer detection (1)
- cancer diagnosis (1)
- cancer risk (1)
- cancer risk factors (1)
- cancer therapy (1)
- cancer-testis antigens (1)
- candidate genes (1)
- cannabinoid receptor-1 antagonist (1)
- capecitabine (1)
- carcinogenesis (1)
- carcinoma (1)
- carcinoma metastases to pancreas (1)
- cardiac amyloidosis (1)
- cardiac arrest (1)
- cardiac dysfunction (1)
- cardiac energy metabolism (1)
- cardiac function (1)
- cardiac implantable electronic devices (CIED) (1)
- cardiac implants (1)
- cardiac magnetic resonance (1)
- cardiac metabolism (1)
- cardiac myocytes (1)
- cardiac pacing (1)
- cardiac remodeling (1)
- cardiac resynchronization therapy (CRT) (1)
- cardiac tamponade (1)
- cardiac thrombi (1)
- cardiac training group (1)
- cardiac transplantation (1)
- cardiac troponin T (1)
- cardiac ventricles (1)
- cardiogenetics (1)
- cardiomyopathies (1)
- cardioprotection (1)
- cardiopulmonary bypass (1)
- cardiopulmonary exercise capacity (1)
- cardiovascular MRI (1)
- cardiovascular care (1)
- cardiovascular death (1)
- cardiovascular drugs (1)
- cardiovascular magnetic-resonance (1)
- cardiovascular mortality (1)
- cardiovascular munster procam (1)
- cardiovascular outcomes (1)
- cardiovascularm disease (1)
- carotid artery disease (1)
- case report (1)
- caspase-3 (1)
- catecholamines (1)
- catenin (1)
- catheter tip (1)
- cathetersepsis (1)
- catheterthrombosis (1)
- cell biology (1)
- cell cultures (1)
- cell fusion (1)
- cell lines (1)
- cell staining (1)
- cell therapy (1)
- cells (1)
- cellular physiology (1)
- central nervous system (1)
- centrosomal protein (1)
- cerebrovascular diseases (1)
- channel transport (1)
- channelopathie (1)
- chemokines (1)
- child (1)
- chirotherapy (1)
- cholesterol (1)
- cholesterol metabolism (1)
- cholesterol- uptake (1)
- chromosomale Verlustanalyse (1)
- chromosomes (1)
- chronic distress (1)
- chronic heart failure (CHF) (1)
- chronic kidney disease (CKD) (1)
- chronic myeloid leukemia (1)
- chronic thromboembolic pulmonary hypertension (1)
- chronische Hyponatriämie (1)
- chronotype (1)
- cigarette smoking (1)
- circadian rhythms (1)
- circadian therapy (1)
- circulating microRNA (1)
- classical activation pathway (1)
- clearance (1)
- clinical (1)
- clinical data warehouse (1)
- clinical manifestations (1)
- clinical routine data (1)
- clinical study (1)
- clinical systems (1)
- clinical trial (1)
- clodronat-liposome (1)
- clonal hematopoiesis of indeterminate potential (1)
- cloning of putative human promoter sequence (1)
- closure AV fistula/AVM (CLAV) (1)
- co-morbid depression (1)
- coa reductase inhibitors (1)
- coagulation (1)
- coaptation line (1)
- cognition (1)
- coherent anti-Stokes Raman scattering (CARS) microscopy (1)
- cohort study (1)
- colestilan (1)
- colloids (1)
- colon carcinogenesis (1)
- color-coded (1)
- colorectal carcinoma (1)
- combination (1)
- company health care programme (1)
- comparability (1)
- comparative genomic hybridization (1)
- complex (1)
- complex‐valued machine learning (1)
- compliance (1)
- comprehensive psychosomatic assessment (1)
- computed tomography (1)
- condensation (1)
- confounders (1)
- consensus conference (1)
- contact force (1)
- converting enzyme-inhibition (1)
- cornea verticillata (1)
- coronary calcification (1)
- coronary stent (1)
- coronary-artery calcification (1)
- coronary-heart-disease (1)
- correction (1)
- cortical OAT1 (1)
- corticosteroid withdrawal (1)
- corticosteroid-free immunosuppression after renal transplantation (1)
- cortisol-producing adenoma (1)
- creatine kinase (1)
- creatine synthesis (1)
- creatinine (1)
- cryptogenic stroke (1)
- cushing's syndrome (1)
- cyclic (1)
- cyclic nucleotides such as cyclic adenosine monophosphate (1)
- cyclosporine (1)
- cystatin c (1)
- cytochrome P450 3A4 (CYP3A4) (1)
- cytoplasmic staining (1)
- cytosol (1)
- dabrafenib (1)
- data augmentation (1)
- data warehouse (1)
- death rates (1)
- deep-vein thrombosis (1)
- deficient mice (1)
- demography (1)
- desmin-related myopathy (1)
- desminopathy (1)
- desmocollin-2 (1)
- desmoglein-2 (1)
- deubiquitinases (1)
- diabetes complications (1)
- diabetes insipidus (1)
- diabetes melitus (1)
- diabetes mellitus type 2 (1)
- diabetes typ 1 (1)
- diabetic cardiomyopathy (1)
- diabetic kidney disease (1)
- diabetic mouse (1)
- diabetic nephropathy (1)
- diabetische Kardiomyopathie (1)
- diagnosis in Fabry disease (1)
- diagnostic (1)
- diagnostic medicine (1)
- dialysate (1)
- dialysis membrane (1)
- dialyzer membrane (1)
- diastolic dysfunction (1)
- diastolic function (1)
- dietary approaches to stop hypertension (1)
- dietary sodium (1)
- dietary sodium restriction (1)
- digital Health (1)
- digital phenotyping (1)
- digital subtraction angiography (1)
- dilated cardiomyopathy (1)
- dilated cardiomyopathy with ataxia (1)
- dimensions (1)
- disease (1)
- disease score (1)
- disease severity (1)
- dissection (1)
- distant metastases (1)
- dobutamine stress echocardiography (1)
- documentation quality (1)
- dogs (1)
- double knockout mice (1)
- double-blind (1)
- doule blind (1)
- down regulation (1)
- drug interaction (1)
- drug intoxication (1)
- drug monitoring (1)
- drug therapy (1)
- drug toxicity (1)
- drug transporter (1)
- drug treatment (1)
- drug–drug interactions (DDIs) (1)
- duration of survival (1)
- dynamic (1)
- dysfunction (1)
- eGFR (1)
- eNOS-knockout (1)
- early prognosis (1)
- early-stage osteonecrosis (1)
- ecg (1)
- ecological momentary assessment (1)
- ectopic (1)
- eculizumab (1)
- elective PCI (1)
- electrocardiogram (1)
- electrocardiography (1)
- electromagnetic tracking system (1)
- electronic data capture (1)
- electronic health records (1)
- electrophysiology (1)
- electrophysiology study (1)
- electroporation (1)
- elektive perkutane Koronarintervention (1)
- elektromagnetisches Trackingsystem (1)
- empagliflozin (1)
- end stage renal disease (1)
- end-stage kidney disease (1)
- endocrine cancer (1)
- endocrinology (1)
- endogenous hypercortisolism (1)
- endothelial (1)
- endothelial activation (1)
- endothelial adhesion molecules (1)
- endothelial cell interactions (1)
- endothelial cells (1)
- endotheliale Adhäsionsmoleküle (1)
- endotheliale Stickstoffmonoxid-Synthase (1)
- endothelin-1 (1)
- endovascular (1)
- energy homeostasis (1)
- enoxaparin (1)
- entresto (1)
- entropy production (1)
- environmental health (1)
- environmental impact (1)
- eosinophils (1)
- epithelial markers (1)
- epithelial to mesenchymal transition (1)
- erythropoietin resistance (1)
- estrogen (1)
- estrogen receptor (1)
- euroaspire (1)
- evidence-based practice (1)
- exercise (1)
- expectations (1)
- expression (1)
- extended matching questions (1)
- extracellular matrix (1)
- extracellular matrix remodeling (1)
- ezetimibe (1)
- factor XI (1)
- factor XII (1)
- failing heart (1)
- fall (1)
- fatal cardiovascular disease (1)
- fatty acids (1)
- fatty liver (1)
- feature selection (1)
- feedback (1)
- female Fabry patients (1)
- ferritin (1)
- fetuin A (1)
- fibroblast (1)
- fibroblast growth factor-23 (1)
- fibroblast growth factors (1)
- fibrocyt (1)
- fibronectin (1)
- filamin-C (1)
- flow (1)
- flow dynamics (1)
- flow patterns (1)
- fluorescence resonance energy transfer (1)
- focal semental glomerulosclerosis (1)
- focused surgical approach (1)
- food consumption (1)
- fortgeschrittenes Nebennierenkarzinom (1)
- fourth (1)
- fractionation membranev (1)
- fracture (1)
- fragmin (1)
- free energy (1)
- free fatty acids (1)
- free light chains (1)
- functional magnetic resonance imaging (1)
- functional regurgitation (1)
- funktionelle MRT (1)
- gamma delta (1)
- gastric cancer (1)
- gefitinib (1)
- gender (1)
- gene (1)
- gene expression (1)
- gene variant (1)
- gene-environment interaction (1)
- gene-therapy (1)
- genetic analysis (1)
- genetic loci (1)
- genetic renal disease (1)
- genetically modified animals (1)
- genome-wide association study (1)
- genotype/phenotype correlation (1)
- genotyping (1)
- geriatrische Nephrologie (1)
- giant cell arteritis (1)
- glial damage (1)
- glial fibrillary acidic protein (1)
- glioblastoma (1)
- global longitudinal strain (1)
- global outcomes (1)
- glomerular-filtration-rate (1)
- glomerulonephritis (1)
- glucocorticoid excess (1)
- glucocorticoid replacement regimens (1)
- glucocorticoid replacement therapy (1)
- glucose effectiveness (1)
- glucose homeostasis (1)
- glucose tolerance test (1)
- gp91phox (1)
- graft (1)
- graft versus host disease (1)
- green fluorescent protein (1)
- growth differentiation factor 15 (1)
- growth hormone deficiency (1)
- guanylyl cyclase (1)
- guideline implementation (1)
- guideline-directed medical therapy (1)
- gut microbiome (1)
- hENT1 (1)
- haemodiafiltration (1)
- haplotype (1)
- hashimotos-thyroiditis (1)
- healing and remodelling processes (1)
- health care (1)
- health care research (1)
- health economics (1)
- health policy (1)
- health questionnaire (1)
- health related quality of life (1)
- health risk assessment (1)
- healthcare workers (1)
- hearing loss (1)
- hearrate (1)
- heart disease (1)
- heart failure training group (1)
- heart failure with mid-range ejection fraction (1)
- heart failure with reduced ejection fraction (1)
- helicopter (1)
- heme oxygenase-1 (1)
- hemodynamic (1)
- hemoglobin (1)
- heodialysis patients (1)
- high denisty lipoprotein (1)
- high dose dexamethasone suppression test (1)
- high molecular weight adiponectin (1)
- high-dose atorvastatin (1)
- high-resolution analysis (1)
- hip fracture (1)
- histopathology (1)
- home telemonitoring (1)
- homeostasis (1)
- homeostasisIon channels (1)
- hormones (1)
- hs-CRP (1)
- human behaviour (1)
- human serum albumin (1)
- hydrocortisone (1)
- hydroxy-dabrafenib (1)
- hyperandrogenemia (1)
- hypercholesterinämie (1)
- hyperosmolality (1)
- hyperphosphataemia (1)
- hypersensitivity (1)
- hypertensive crises (1)
- hypertensiver Krise (1)
- hyponatremia (1)
- hypopituitary patients (1)
- hypothalamic gene expression (1)
- hypothalamische Adipositas (1)
- iNOS (1)
- iPSC-CMs (1)
- identical twins (1)
- idiopathic osteonecrosis (1)
- idiopathic pulmonary fibrosis (1)
- imaging (1)
- imaging TTE/TEE (ITTE) (1)
- immune check inhibitor (1)
- immune checkpoint inhibitor (ICI) (1)
- immunity (1)
- immuno-modulation (1)
- immunoassays (1)
- immunofluorescence (1)
- immunohistochemistry techniques (1)
- immunosenescence (1)
- immunspressive Therapie (1)
- implantable cardioverter defibrillator (ICD) (1)
- implantation (1)
- in silico analysis (1)
- in vivo (1)
- inappropriate prescription (1)
- incidence (1)
- incremental cost-effectiveness ratio (ICER) (1)
- indoxyl sulfate (1)
- induced insulin-release (1)
- inebilizumab (1)
- infarct thickness (1)
- infarct volume (1)
- infarction size (1)
- infection (1)
- infections (1)
- inflammaging (1)
- information extraction (1)
- inherited metabolic disorders (1)
- inhibitor of tyrosinkinase (1)
- inos (1)
- insufficiency (1)
- insulin tolerance test (1)
- intake (1)
- intensive care medicine (1)
- intensive care transport (1)
- intensive glucose control (1)
- interconversion (1)
- interhospital transfer (1)
- interleukin-6 (1)
- interleukin-8 (1)
- intermediate filaments (1)
- interparticle interaction (1)
- intra-individueller Vergleich (1)
- intragastric balloon (1)
- intrazellulärer Stress (1)
- ionic strength (1)
- iron (1)
- iron oxide contrast agent (1)
- irradiated fibroblasts (1)
- ischemia-reperfusion (1)
- ischemia-reperfusion injury (1)
- ischemic (1)
- ischemic acute kidney injury model (1)
- ischemic heart failure (1)
- ischämische Herzinsuffizienz (1)
- isoproterenol (1)
- isturisa (1)
- italian population (1)
- kardiale Amyloidose (1)
- kardiales Remodeling (1)
- kardioprotektiv (1)
- kardiopulmonale Leistungsfähigkeit (1)
- kardiovaskuläre Ereignisse (1)
- kardiovaskuläre Risikoevaluation (1)
- kardiovaskuläre Risikofaktoren (1)
- kardiovaskulärer Surrogat (1)
- kidney disease (1)
- kidney disease; (1)
- kidney function (1)
- kidney ischemia/reperfusion injury (1)
- kidney-disease CKD (1)
- kinase (1)
- kinase inhibitors (1)
- kinases (1)
- kinetics of oxygen uptake (1)
- klassischer Aktivierungsweg (1)
- knockout mice (1)
- knockout-Mäuse (1)
- kognitive Beeinträchtigung (1)
- kollagen deficiency (1)
- komorbide Depression (1)
- kontemplative Meditation und Atemtechniken (CMBT) (1)
- koronare Herzkrankheit (1)
- lactase persistence (1)
- lactic acidosis (1)
- lactose (1)
- large animal models (1)
- late gadolinium enhancement (1)
- laxative (1)
- leaflet (1)
- left lateral wall (1)
- left ventricular geometric abnormality (1)
- left ventricular geometry (1)
- left ventricular mass index (1)
- left ventricular non-compaction (1)
- left ventricular performance (1)
- left ventricular remodeling (1)
- left ventricular thrombus (1)
- left ventricular thrombusv (1)
- left-ventricular hypertrophy (1)
- leicht reduzierte Herzinsuffizienz (1)
- leitliniengerechte Pharmakotherapie (1)
- leitliniengerechte Therapie (1)
- leptin system (1)
- lesion formation (1)
- lesion size (1)
- lesions (1)
- leukocyte adhesion (1)
- leukocyte-endothelial-interactions (1)
- leukocytes (1)
- lifestyle (1)
- lifestyle modification (1)
- linkage (1)
- linksventrikulärer Thrombus (1)
- lipid droplets (1)
- lipid rafts (1)
- lipid-lowering therapy (1)
- lipoprotein apheresis (1)
- lipoprotein(a) (1)
- lipoxygenase (1)
- lipoxygenase knockout (1)
- liquid chromatography tandem mass spectrometry (LC-MS/MS (1)
- livin (1)
- lncRNA (1)
- long-term follow-up (1)
- long-term ventilation (1)
- longitudinal function (1)
- longitudinal studies (1)
- longitudinale Funktion (1)
- loss (1)
- low molecular weight (1)
- low-gradient AS (1)
- lower limit of normal (1)
- lung cancer (1)
- lung fibroblasts (1)
- lycopene (1)
- lymph node dissection (1)
- lymph nodes (1)
- lymphadenectomy (1)
- lysophosphatidylcholine (1)
- lysosomal storage disorder (1)
- lyso‐Gb3 (1)
- m exercise training (1)
- mCRP (1)
- mHealth (1)
- macrophages (1)
- macrovascular (1)
- magnetic resonance (1)
- magnetic resonance spectroscopy (1)
- magnetic resonsance imaging (1)
- malignant tumors (1)
- manuelle Diagnostik (1)
- mass spectrometry (1)
- mass spectronomy (1)
- meat (1)
- medical data integration center (1)
- medical dialysis (1)
- medical informatics initiative (1)
- medical students (1)
- medical therapy (1)
- medication extraction (1)
- medium cut-off dialyzer (1)
- medullary thyroid cancer (1)
- membranous nephropathy (1)
- men born (1)
- menopause (1)
- mental impairment (1)
- mesenchymal markers (1)
- meta-analysis (1)
- metabolic syndrome (1)
- metabolically unhealthy obesity (1)
- metachronous (1)
- metastasis (1)
- metformin (1)
- metyrapone (1)
- miR-182-5p (1)
- miR-183 cluster (1)
- miR-483-5p (1)
- miRNA infarcted heart (1)
- miRNS (1)
- mices (1)
- microcirculation (1)
- microscopy (1)
- microvascular (1)
- mild (1)
- mild to moderate CKD (1)
- military (1)
- mineral bone density (1)
- mineralocorticoid antagonist (1)
- minerals (1)
- minimal regional loss (1)
- minimale Verlustregion (1)
- mitochondria (1)
- mitochondria function and morphology (1)
- mitochondrial mRyR1 (1)
- mitofusin 2 (1)
- mitogenic signal transduction (1)
- mitosis (1)
- mitral ring displacement (1)
- mitral ring motion (1)
- mitral valve (1)
- mittlerer transvalvulärer Druckgradient (1)
- mobile crowdsensing (1)
- mobile health (1)
- model (1)
- modified-release hydrocortisone (1)
- molecular biology (1)
- molecular diagnostics (1)
- molecular medicine (1)
- monocytes (1)
- mortality reduction (1)
- mouse model (1)
- multi-tyrosine kinase inhibitor (1)
- multicenter study (1)
- multidetector computed-tomography (1)
- multiple choice questions (1)
- multiple sclerosis (1)
- multivariate data analysis (1)
- multizentrische Studie (1)
- muscle fiber types (1)
- mutation (1)
- mutation databases (1)
- mutation triggers (1)
- mutations (1)
- myocardial (1)
- myocardial aging (1)
- myocardial ischemia (1)
- myocardial lipid content (1)
- myocardial work efficiency (1)
- myocardial fibrosis (1)
- myocardial-infarction (1)
- myocarditis (1)
- myocardium (1)
- myokardial infarction (1)
- myokardiale Hypertrophie (1)
- myosin heavy chain (1)
- nCRP (1)
- natural history (1)
- natural-history data (1)
- neck circumference (1)
- neonatal (1)
- neoplasm (1)
- nephrotic syndrome (1)
- nerve fibers (1)
- neural networks (1)
- neuroblastoma – diagnosis (1)
- neurofibromatosis type 1 (1)
- neuroinflammation (1)
- neurological (1)
- neurological complications (1)
- neurology (1)
- neuromyelitis optica spectrum disorders (1)
- neuronal nitric oxide synthase (1)
- neurons (1)
- neuropathy (1)
- neuroscience (1)
- neutral loss (1)
- neutrophils (1)
- nictric-oxide (1)
- nitric oxide bioavailability (1)
- non small cell lung cancer (1)
- non-Disjunktion (1)
- non-disjunction (1)
- non-equilibrium thermodynamics (1)
- non-triggered (1)
- nontraumatic osteonecrosis of the femoral head (1)
- normal adrenal glands (1)
- normal values (1)
- normotensiv (1)
- normotensive (1)
- notch signaling (1)
- nuclear staining (1)
- nutritional components (1)
- nutritional counseling (1)
- nutritional medical needs (1)
- nutritional risk screening (1)
- obesity surgery (1)
- observational study (1)
- occupational-status (1)
- oligonucleotides (1)
- on-site examination (1)
- oncology outpatients (1)
- openEHR (1)
- opossum kidney cells (1)
- optimale Herzkatheterprojektionen (1)
- optional angiographic views (1)
- oral chemotherapy (1)
- oral glucose (1)
- orale Chemotherapie (1)
- organoid (1)
- oscillating biomagnetic fields (1)
- osilodrostat (1)
- osimertinib (1)
- osmotic stimulation (1)
- osteogenesis imperfecta (1)
- ostial segments (1)
- outcome (1)
- overload (1)
- overweight simulation (1)
- oxidativer Stress (1)
- oxidized LDL (1)
- oxidized low-density-lipoprotein (1)
- p-cresyl sulfate (1)
- p38 MAPK (1)
- pancreatic beta cell (1)
- pandemia (1)
- panel (1)
- pankreatische beta-Zelle (1)
- papillary (1)
- papillary thyroid carcinoma (PTC) (1)
- para-Cresyl-Sulfat (1)
- parallel imaging (1)
- parathyroid adenoma (1)
- parathyroid carcinoma (1)
- paravalvular regurgitation (1)
- pathogenesis (1)
- pathophysiology (1)
- patient survival (1)
- patientenorientierte Versorgung (1)
- patients’ awareness (1)
- pediatric (1)
- pediatric adrenocortical adenoma (1)
- pediatric adrenocortical carcinoma (1)
- pembrolizumab (1)
- peptide tyrosine tyrosine 3-36 (PYY3-36) (1)
- peptide tyrosine tyrosine 3-36 (PYY\(_{3-36}\)) (1)
- percutaneous valve therapy (PVT) (1)
- performance (1)
- pericardiocentesis (1)
- perioperative chemotherapy (1)
- peritoneal carcinomatosis (1)
- perkutane transluminale koronare Angioplastie (1)
- personalised medicine (1)
- personalized antimicrobial therapy (1)
- personalized medicine (1)
- personalized treatment (1)
- pharmacoepidemiology (1)
- pharmacokinetics (1)
- pharmacotherapy (1)
- phase IV (1)
- phase-contrast CMR (1)
- phase-contrast MRI (1)
- pheochromocytoma/paraganglioma (1)
- pheochromozytom (1)
- phosphate homeostasis (1)
- phosphatidylcholines (1)
- phosphoantigens (1)
- phosphodiesterase inhibitor (1)
- phospholipid fatty acids (1)
- phosphorylated tau protein (1)
- phosphorylation (1)
- physicians’ awareness (1)
- physiologically based pharmacokinetic (PBPK) modeling (1)
- physische Aktivität (1)
- pig (1)
- pioglitazone (1)
- piperacillin/tazobactam (1)
- pituitary (1)
- pituitary adenomas (1)
- pituitary gland (1)
- placebo (1)
- plant-derived metabolites (1)
- plaque (1)
- plaque characteristics (1)
- plasma NMR (1)
- plasma proteins (1)
- plasmid construction (1)
- platelet (1)
- platelet activation (1)
- platelet adhesion (1)
- platinum (1)
- pleural mesothelioma (1)
- podocyte (1)
- polarization (1)
- poly(2-oxazoline) (1)
- polycystic ovary syndrome (1)
- polyglandular autoimmune syndrome (1)
- polymorphism (1)
- polymyalgia rheumatica (1)
- population pharmacokinetics (1)
- population-based (1)
- population-based study (1)
- posaconazole (1)
- post-traumatic stress disorder (1)
- postoperativ (1)
- postprandial hyperglycemia (1)
- postprandiale Hyperglykämie (1)
- posttraumatische Belastungsstörung (1)
- poultry (1)
- preanalytical conditions (1)
- preclinical research (1)
- prediction model (1)
- predictive biomarker (1)
- predictive marker (1)
- predictors (1)
- premature mortality (1)
- preserved ejection fraction (1)
- preventive medicine (1)
- primary care (1)
- primary healthcare (1)
- primary hyperparathyroidism (1)
- primary polydipsia (1)
- procollagen (1)
- prognostic (1)
- prognostic marker (1)
- prognostic markers (1)
- prognostischer Marker (1)
- progression (1)
- proliferationsassoziierte Signaltransduktion (1)
- promoter regulation (1)
- propionic acid (1)
- prospective (1)
- prospektive Studie (1)
- prostaglandin e2 (1)
- prostate cancer (1)
- protein expression (1)
- protein kinase a (1)
- protein p8 (1)
- protein-bound solutes (1)
- protein-bound uremic toxins (1)
- proteomic (1)
- prädiktiver Marker (1)
- pseudo-severe AS (1)
- pseudo-severe aortic stenosis (1)
- psychopharmacology (1)
- psychotherapy (1)
- public health (1)
- pulmonary artery pressure (1)
- pulmonary cancer (1)
- pulmonary fibrosis (1)
- pulse-wave velocity (1)
- qualitative Forschung (1)
- quantitative MRI (1)
- radiation fibrosis (1)
- radiation pneumonitis (1)
- radiation therapy (1)
- radical resection (1)
- radii (1)
- radiochemotherapy (1)
- radiofrequency ablation (1)
- radiogene Lungenfibrose (1)
- radiogenic lung fibrosis (1)
- radioiodine (1)
- radioiodine therapy (1)
- radiotherapy (1)
- randomized controlled-trial (1)
- randomized trial (1)
- rare diseases (1)
- rat kidney (1)
- ravulizumab (1)
- reaktive Sauerstoffspezies (1)
- real-world (1)
- rearranged during transfection (1)
- recombination hotspot (1)
- recommendations (1)
- recovery (1)
- recurrence free survival (1)
- recurrence survival (1)
- recurrence-free survival (1)
- recurrent Tako-Tsubo cardiomyopathy (1)
- reduzierte Herzinsuffizienz (1)
- reference data (1)
- refugee healthcare (1)
- regression analysis (1)
- regulation of expression (1)
- regurgitation (1)
- remote monitoring (1)
- removal (1)
- renal (1)
- renal artery (1)
- renal disease (1)
- renal dysfunction (1)
- renal fibrosis (1)
- renal osteodystrophy (1)
- renal replacement therapy (1)
- renal system (1)
- renoprotection (1)
- reoperation (1)
- repeated (1)
- repeated surgery (1)
- replacement therapy (1)
- reporter gen assay (1)
- reproductive disorders (1)
- research infrastructure (1)
- residual cardiovascular risk (1)
- respiratory signs and symptoms (1)
- retrospektiv (1)
- review (1)
- re‐transplantation (1)
- rheumatic disease (1)
- rheumatoid arthritis (1)
- rhoA (1)
- right ventricular dysfunction (1)
- risk (1)
- risk factor control (1)
- risk prediction scores (1)
- risk stratification (1)
- rodent model (1)
- root (1)
- running wheel (1)
- ruxolitinib (1)
- rygb (1)
- sGC (1)
- sacubitril-valsartan (1)
- salt-dependend (1)
- salzinduziert (1)
- sarcoidosis (1)
- satralizumab (1)
- scale (1)
- sclerostin (1)
- secondary data usage (1)
- secondary prevention (1)
- segmentation (1)
- self-gating (1)
- self-navigation (1)
- selpercatinib (1)
- semantic interoperability (1)
- septal hypertrophy (1)
- septic shock (1)
- sequence databases (1)
- serielle Messungen (1)
- seroprevalence (1)
- serotonin (1)
- serotonin transporter deficient mice (1)
- serum (1)
- serum creatinine (1)
- sevelamer (1)
- severe renal insufficiency (1)
- severe sepsis (1)
- sex addiction (1)
- sex differences (1)
- shear stress (1)
- shimming (1)
- short Synacthen test (1)
- short term (1)
- short-chain fatty acids (1)
- signal voids (1)
- signalling (1)
- signs and symptoms (1)
- simulation (1)
- single nucleotide polymorphisms (1)
- skin diseases (1)
- slow component of oxygen uptake (1)
- small animal (1)
- small cell lung cancer (SCLC) (1)
- smoking (1)
- sodium (1)
- sodium channel (1)
- sodium-23 (1)
- sodium-glucose co-transporter-2 inhibitors (1)
- solubility enhancement (1)
- somatic mutations (1)
- somatostatin receptor (1)
- spannungsabhängig (1)
- speckle tracking (1)
- speckle tracking imaging (1)
- speech recognition (1)
- sphingolipids (1)
- spin lock (1)
- spin-lock (1)
- spiritual-wholistic treatment (1)
- sports and exercise medicine (1)
- standard heparin (1)
- standardization (1)
- state space (1)
- statement (1)
- statistical mechanics (1)
- stenosis (1)
- stepcount (1)
- steroids (1)
- strain (1)
- strain rate (1)
- stress induced Hypertension (1)
- stressinduzierte Hypertonie (1)
- subjective health-status (1)
- sudden death (1)
- sudden unexpected death in epilepsy (1)
- sulfonylurea (1)
- super-obesity (1)
- superparamagnetische Eisenoxid Kontrastmittel (1)
- surgical and invasive medical procedures (1)
- surgical oncology (1)
- surgical repair (1)
- surgical treatment (1)
- surveillance (1)
- susceptibility (1)
- symptoms (1)
- systemic micro-inflammation oxidative stress (1)
- systems biology (1)
- t-lymphocytes (1)
- tail cuff method (1)
- target therapies (1)
- targeted gene panel (1)
- targeted metabolomics (1)
- targeted therapy (1)
- targeted treatment (1)
- task force (1)
- telemedicine (1)
- telomeres (1)
- temperature (1)
- tenting (1)
- term fenofibrate therapy (1)
- terminale Niereninsuffizienz (1)
- testosterone (1)
- therapeutic approach (1)
- therapeutic management (1)
- therapeutic options (1)
- thermodynamics (1)
- third (1)
- thoracic aorta (1)
- three-dimensional echocardiography (1)
- thrombocyte activation (1)
- thromboembolism (1)
- thromboinflammation (1)
- thrombopoiesis (1)
- thyroid carcinoma (TC) (1)
- tight junctions (1)
- timing (1)
- tissue (1)
- tissue doppler (1)
- tissue velocity imaging (1)
- tocilizumab (1)
- tomography (1)
- topoisomerase II alpha (1)
- training (1)
- trametinib (1)
- transcatheter valveimplantation (TVI) (1)
- transfection (1)
- transfer learning (1)
- transforming growth factor beta 1 (1)
- transgen (1)
- transgenic (1)
- transgenic mouse (1)
- transgenic rats (1)
- translation (1)
- translational research (1)
- transport experiments (1)
- transthoracic echocardiography (1)
- treatment outcome (1)
- trial design (1)
- tricuspid pressure gradient (1)
- triglyceride-rich lipoproteins (1)
- troponin T (1)
- true-severe aortic stenosis (1)
- tumor (1)
- tumor microenvironment (1)
- tumor suppressor gene (1)
- tumor-infiltrating (1)
- tumors (1)
- tumour (1)
- two-hybrid system (1)
- type 2 (1)
- type 2 diabetes mellitus (1)
- type-1 diabetes mellitus (1)
- type-2 diabetes mellitus (1)
- tyrosine kinase inhibitor (TKI) (1)
- tyrosine kinase inhibitors (1)
- ublituximab (1)
- ultra highfield magnetic resonance imaging (1)
- ultrahigh field (1)
- ultrahigh-field (1)
- ultrahigh-field MRI (1)
- ultrasound guided (1)
- uneventful initial battery lifespan (1)
- unfractionated heparin (1)
- ungeschützter linker Hauptstamm (1)
- univentricular heart (1)
- unprotected left main (1)
- unsupervised clustering (1)
- urinary protein excretion (1)
- usability (1)
- use (1)
- user-centered design (1)
- validity (1)
- variant (1)
- vascular calcification (1)
- vascular cell adhesion molecules (1)
- vascular surgery (1)
- vaskuläre Adhäsionsmoleküle (1)
- vasoconstriction (1)
- vemurafenib (1)
- ventricular fibrillation (1)
- ventricular ruptur (1)
- ventricular tachycardia (1)
- ventrikuläre Tachykardie (1)
- verification of suspected diagnoses (1)
- vertigo (1)
- vibration (1)
- viral infection (1)
- virtual-reality (1)
- vitamins (1)
- voltage (1)
- volume (1)
- volumetric absorptive micro-sampling (VAMS) (1)
- waist circumference (1)
- warfarin (1)
- weaning (1)
- whole exome sequencing (1)
- wires (1)
- yellow fluorescent protein (1)
- zentrosomales Protein (1)
- Übergewicht (1)
- Übergewichts-Simulation (1)
- Überleben (1)
- ältere Menschen (1)
- α- und β-Agalsidase (1)
- α-Agalsidase (1)
- α-galactosidase A (1)
- α‐GalA 3D‐structure (1)
- β-Agalsidase (1)
Institute
- Medizinische Klinik und Poliklinik I (635) (remove)
Sonstige beteiligte Institutionen
- Zentraleinheit Klinische Massenspektrometrie (3)
- Johns Hopkins School of Medicine (2)
- Johns Hopkins School of Medicine, Baltimore, MD, U.S. (2)
- Apotheke, Universitätsklinikum Würzburg (1)
- Center for Interdisciplinary Clinical Research, Würzburg University, Würzburg, Germany (1)
- Datenintegrationszentrum Würzburg (DIZ) (1)
- Hospital Augsburg, Augsburg, Germany (1)
- Interdisziplinäre Biomaterial- und Datenbank Würzburg (ibdw) (1)
- Johns Hopkins University School of Medicine (1)
- Joslin Diabetes Center (Harvard Medical School) (1)
Objectives
The spectrum of giant cell arteritis (GCA) and polymyalgia rheumatica (PMR) represents highly inflammatory rheumatic diseases. Patients mostly report severe physical impairment. Possible consequences for mental health have been scarcely studied. The aim of this study was to investigate psychological well-being in the context of GCA and PMR.
Methods
Cross-sectional study with N = 100 patients with GCA and/or PMR (GCA-PMR). Patient-reported outcomes (PROs) were measured using the Short Form 36 Version 2 (SF-36v2) and visual analog scale (VAS) assessment. Moreover, the Patient Health Questionnaire 9 (PHQ-9) was used in 35 of 100 patients to detect depression. To compare PROs with physician assessment, VAS was also rated from physician perspective. To assess a possible association with inflammation itself, serological parameters of inflammation (C-reactive protein [CRP], erythrocyte sedimentation rate [ESR]) were included.
Results
In all scales of the SF-36v2 except General Health (GH) and in the physical and mental sum score (PCS, MCS), a significant impairment compared to the German reference collective was evident (MCS: d = 0.533, p < 0.001). In the PHQ-9 categorization, 14 of the 35 (40%) showed evidence of major depression disorder. VAS Patient correlated significantly with PHQ-9 and SF-36 in all categories, while VAS Physician showed only correlations to physical categories and not in the mental dimensions. Regarding inflammatory parameters, linear regression showed CRP to be a complementary significant positive predictor of mental health subscale score, independent of pain.
Conclusion
PRO show a relevant impairment of mental health up to symptoms of major depression disorder. The degree of depressive symptoms is also distinctly associated with the serological inflammatory marker CRP.
Purpose
Over the course of COVID-19 pandemic, evidence has accumulated that SARS-CoV-2 infections may affect multiple organs and have serious clinical sequelae, but on-site clinical examinations with non-hospitalized samples are rare. We, therefore, aimed to systematically assess the long-term health status of samples of hospitalized and non-hospitalized SARS-CoV-2 infected individuals from three regions in Germany.
Methods
The present paper describes the COVIDOM-study within the population-based cohort platform (POP) which has been established under the auspices of the NAPKON infrastructure (German National Pandemic Cohort Network) of the national Network University Medicine (NUM). Comprehensive health assessments among SARS-CoV-2 infected individuals are conducted at least 6 months after the acute infection at the study sites Kiel, Würzburg and Berlin. Potential participants were identified and contacted via the local public health authorities, irrespective of the severity of the initial infection. A harmonized examination protocol has been implemented, consisting of detailed assessments of medical history, physical examinations, and the collection of multiple biosamples (e.g., serum, plasma, saliva, urine) for future analyses. In addition, patient-reported perception of the impact of local pandemic-related measures and infection on quality-of-life are obtained.
Results
As of July 2021, in total 6813 individuals infected in 2020 have been invited into the COVIDOM-study. Of these, about 36% wished to participate and 1295 have already been examined at least once.
Conclusion
NAPKON-POP COVIDOM-study complements other Long COVID studies assessing the long-term consequences of an infection with SARS-CoV-2 by providing detailed health data of population-based samples, including individuals with various degrees of disease severity.
Trial registration
Registered at the German registry for clinical studies (DRKS00023742).
Ziel dieser Studie war es, zu eruieren, ob die DSE zur Unterscheidung einer TS- von einer PSAS beitragen kann. Ebenfalls untersuchten wir, ob es bestimmte echokardiographische Prädiktoren für eine TS- und eine PSAS gibt und ob die LVEF bei Patienten mit einer LGAS eine entscheidende Rolle spielt. Methoden: Es wurde bei 130 Patienten mit einer asymptomatischen AS im Uniklinikum Würzburg zwischen Januar 2011 und Dezember 2016 sowohl eine TTE als auch eine DSE durchgeführt. Mittels TTE wurden verschiedene echokardiographische Daten erhoben und falls die Patienten eine AVAi 0,6 cm2/m2 und eine PGmean < 40 mmHg aufwiesen, wurden sie in die Studie eingeschlossen. Sie wurden in zwei Gruppen aufgeteilt, je nachdem ob sie eine LGAS mit einer LVEF 50% oder < 50% aufwiesen. Bei allen Patienten wurde in der DSE die AVAproj berechnet und sie wurden daraufhin in zwei Untergruppen aufgeteilt, Patienten mit einer AVAproj 1 cm2 wurden der Gruppe mit einer hochgradigen LGAS (TS-LGAS) und Patienten mit einer AVAproj > 1cm2 der Gruppe mit einer pseudo-hochgradigen LGAS (PS-LGAS) zugeteilt. Alle Patientendaten wurden manuell ausgewertet. Das klinische Follow Up fand frühestens ein Jahr nach der DSE statt und bestand aus einem Telefoninterview oder einer klinischen Untersuchung. Ergebnisse: Die DSE ist zur Diagnose einer TS-LGAS bei Patienten mit einer erhaltenen LVEF von großem Nutzen. Die in der TTE gemessene AVA ist ein unabhängiger Prädiktor für eine TS-LGAS bei Patienten mit erhaltener und reduzierter LVEF. Eine verringerte MAPSE und eine reduzierte TDI-s´ sprechen bei Patienten mit erhaltener LVEF für eine TS-LGAS. Bei Patienten mit reduzierter LVEF weisen ein erhöhter sPAP und eine verringerte AV Geschwindigkeits Ratio auf eine TS-LGAS hin. Bei Zweifeln können weitere bildgebende Verfahren zur Diagnosefindung hinzugezogen werden.
Diese retrospektive Studie an der Universitätsklinik Würzburg diente der Beurteilung der longitudinalen Funktion in Bezug auf die Gesamtmortalität bei Patienten mit HFmrEF und HFrEF. Die Gruppierung erfolgte anhand der jeweiligen Baseline LVEF. Eine weitere Unterteilung erfolgte in eine ischämische oder nicht-ischämische Genese der HF. Die Subgruppen wurden anhand der Baseline klinischen Charakteristika sowie der echokardiographischen Parameter verglichen. Hier ließ sich ein relativ ähnliches Patientenklientel mit vergleichbarem Alter, Geschlecht, BMI sowie kardialen Risikofaktoren zeigen. Signifikante Unterschiede ergab der Vergleich des NYHA-Stadiums, der Nierenfunktion sowie des Auftretens von Myokardinfarkten.
Die Veränderung der LVEF über die Zeit hat einen zentralen Stellenwert zur Evaluation des Outcomes von Patienten mit HFmrEF und HFrEF. Eine Verbesserung der LVEF fand sich signifikant häufiger bei HFrEF Patienten als bei HFmrEF Patienten, welche über die Zeit signifikant häufiger eine stabile LVEF aufwiesen.
Außerdem war nach Auswertung der Überlebenskurven nach Kaplan-Meier in HFmrEF Patienten eine verbesserte oder unveränderte LVEF über die Zeit mit einem besseren Überleben verbunden, vor allem bei Patienten mit ischämischer Ätiologie. In der HFrEF Gruppe konnte gezeigt werden, dass sowohl Patienten mit ischämischer als auch mit nicht-ischämischer Ätiologie bei Vorliegen einer verbesserten oder unveränderten LVEF über die Zeit ein besseres Outcome aufwiesen.
Eine erniedrigte MAPSE bedeutete vor allem bei HFmrEF Patienten mit nicht-ischämischer Ätiologie ein schlechteres Outcome.
Die Ergebnisse dienten unter anderem der weiteren Charakterisierung der HFmrEF und HFrEF Gruppe sowie der Identifikation von Faktoren zur Beurteilung der Veränderung der LVEF über die Zeit und der Prognose des Langzeitüberlebens beider Gruppen. Ziel für die Zukunft sollte sein, auch für HFmrEF Patienten evidenzbasierte Herzinsuffizienz Therapien zu etablieren.
Hintergrund: Die therapeutischen Optionen für das gering differenzierte (PDTC) und anaplastische (ATC) Schilddrüsenkarzinom sind limitiert, weshalb diese Erkrankungen überwiegend mit einer schlechten Prognose einhergehen. Lenvatinib (LEN) ist ein Multityrosinkinase-Inhibitor, der unter anderem die Fibroblasten-Wachstumsfaktor-Rezeptoren (FGFR) 1-4 inhibiert und zur Therapie des fortgeschrittenen radiojodrefraktären Schilddrüsenkarzinoms zugelassen ist. Es zeigt sich nur ein geringes Ansprechen auf die Monotherapie bei ATCs, wobei neuere Studien eine therapeutische Überlegenheit der Kombination aus LEN und dem PD-1-Inhibitor Pembrolizumab (PEM) beschreiben.
Material und Methoden: Die Expression von PD-L1 wurde in ATC (n=93)- und PDTC (n=47)-Primärtumorgewebe von 1997-2019 aus fünf deutschen (Universitäts-)Kliniken mittels Immunhistochemie analysiert und mit dem Tumor Proportion Score (TPS) quantifiziert. Der Nachweis von FGFR1-4-mRNA wurde bei 31 ATC- und 14 PDTC-Gewebeproben mittels RNAscope In-situ-Hybridisierung quantifiziert. Als Kontrollgruppe wurde normales Schilddrüsengewebe (NT) und Gewebe von papillären Schilddrüsenkarzinomen (PTC) verwendet. Der primäre Endpunkt war das krankheitsspezifische Überleben (DSS).
Ergebnisse: Eine PD-L1-Expression mit einem TPS ≥50% konnte in 42% der ATC- und in 26% der PDTC-Proben nachgewiesen werden. Die mediane PD-L1-Expression war in ATC-(TPS 30%) signifikant höher im Vergleich zu PDTC-Proben (5%; p<0,01) und NT (0%; p<0,001). 53% der PDTC-Proben zeigten eine PD-L1-Expression ≤5%. Die Expression von FGFR-mRNA war in allen Proben sehr gering, wobei die kombinierte FGFR1-4-Expression in PDTC- und ATC-Gewebe im Vergleich zu normalem Schilddrüsengewebe signifikant höher war (jeweils p<0,001). Es ergab sich keine Assoziation zwischen der PD-L1- und FGFR1-4-Expression mit dem krankheitsspezifischen Überleben.
Schlussfolgerung: Eine hohe PD-L1-Expression in einem großen Anteil der ATCs und einem Viertel der PDTCs, könnte auf eine Rationale zur Therapieentscheidung für Immuncheckpoint-Inhibioren hinweisen. Die FGFR-Expression war in allen Schilddrüsenkarzinomen sehr gering. Der klinisch beobachtete Synergismus von PEM und LEN könnte durch immunmodulatorische Effekte hervorgerufen werden.
Background
Adrenal incidentalomas with cortisol autonomy are associated with increased cardiovascular morbidity and mortality. Specific data on the clinical and biochemical course of affected patients are lacking.
Methods
Retrospective study from a tertiary referral centre in Germany. After exclusion of overt hormone excess, malignancy and glucocorticoid medication, patients with adrenal incidentalomas were stratified according to serum cortisol after 1 mg dexamethasone: autonomous cortisol secretion (ACS), >5.0; possible ACS (PACS), 1.9-5.0; non-functioning adenomas (NFA), ≤1.8 µg/dl.
Results
A total of 260 patients were enrolled (147 women (56.5%), median follow-up 8.8 (2.0-20.8) years). At initial diagnosis, median age was 59.5 (20-82) years, and median tumour size was 27 (10-116) mm. Bilateral tumours were more prevalent in ACS (30.0%) and PACS (21.9%) than in NFA (8.1%). Over time, 40/124 (32.3%) patients had a shift of their hormonal secretion pattern (NFA to PACS/ACS, n=15/53; PACS to ACS, n=6/47; ACS to PACS, n=11/24; PACS to NFA, n=8/47). However, none of the patients developed overt Cushing’s syndrome. Sixty-one patients underwent adrenalectomy (NFA, 17.9%; PACS, 24.0%; ACS, 39.0%). When non-operated patients with NFA were compared to PACS and ACS at last follow-up, arterial hypertension (65.3% vs. 81.9% and 92.0%; p<0.05), diabetes (23.8% vs. 35.6% and 40.0%; p<0.01), and thromboembolic events (PACS: HR 3.43, 95%-CI 0.89-13.29; ACS: HR 5.96, 95%-CI 1.33-26.63; p<0.05) were significantly less frequent, along with a trend towards a higher rate of cardiovascular events in case of cortisol autonomy (PACS: HR 2.23, 95%-CI 0.94-5.32; ACS: HR 2.60, 95%-CI 0.87-7.79; p=0.1). Twenty-five (12.6%) of the non-operated patients died, with higher overall mortality in PACS (HR 2.6, 95%-CI 1.0-4.7; p=0.083) and ACS (HR 4.7, 95%-CI 1.6-13.3; p<0.005) compared to NFA. In operated patients, prevalence of arterial hypertension decreased significantly (77.0% at diagnosis to 61.7% at last follow-up; p<0.05). The prevalence of cardiovascular events and mortality did not differ significantly between operated and non-operated patients, whereas thromboembolic events were significantly less frequent in the surgical treatment group.
Conclusion
Our study confirms relevant cardiovascular morbidity in patients with adrenal incidentalomas (especially those with cortisol autonomy). These patients should therefore be monitored carefully, including adequate treatment of typical cardiovascular risk factors. Adrenalectomy was associated with a significantly decreased prevalence of hypertension. However, more than 30% of patients required reclassification according to repeated dexamethasone suppression tests. Thus, cortisol autonomy should ideally be confirmed before making any relevant treatment decision (e.g. adrenalectomy).
Ultra-high field cardiac MRI in large animals and humans for translational cardiovascular research
(2023)
A key step in translational cardiovascular research is the use of large animal models to better understand normal and abnormal physiology, to test drugs or interventions, or to perform studies which would be considered unethical in human subjects. Ultrahigh field magnetic resonance imaging (UHF-MRI) at 7 T field strength is becoming increasingly available for imaging of the heart and, when compared to clinically established field strengths, promises better image quality and image information content, more precise functional analysis, potentially new image contrasts, and as all in-vivo imaging techniques, a reduction of the number of animals per study because of the possibility to scan every animal repeatedly. We present here a solution to the dual use problem of whole-body UHF-MRI systems, which are typically installed in clinical environments, to both UHF-MRI in large animals and humans. Moreover, we provide evidence that in such a research infrastructure UHF-MRI, and ideally combined with a standard small-bore UHF-MRI system, can contribute to a variety of spatial scales in translational cardiovascular research: from cardiac organoids, Zebra fish and rodent hearts to large animal models such as pigs and humans. We present pilot data from serial CINE, late gadolinium enhancement, and susceptibility weighted UHF-MRI in a myocardial infarction model over eight weeks. In 14 pigs which were delivered from a breeding facility in a national SARS-CoV-2 hotspot, we found no infection in the incoming pigs. Human scanning using CINE and phase contrast flow measurements provided good image quality of the left and right ventricle. Agreement of functional analysis between CINE and phase contrast MRI was excellent. MRI in arrested hearts or excised vascular tissue for MRI-based histologic imaging, structural imaging of myofiber and vascular smooth muscle cell architecture using high-resolution diffusion tensor imaging, and UHF-MRI for monitoring free radicals as a surrogate for MRI of reactive oxygen species in studies of oxidative stress are demonstrated. We conclude that UHF-MRI has the potential to become an important precision imaging modality in translational cardiovascular research.
Purpose: This study analyses a large number of cancer patients with CIEDs for device malfunction and premature battery depletion by device interrogation after each radiotherapy fraction and compares different guidelines in regard to patient safety. Methods: From 2007 to 2022, a cohort of 255 patients was analyzed for CIED malfunctions via immediate device interrogation after every RT fraction. Results: Out of 324 series of radiotherapy treatments, with a total number of 5742 CIED interrogations, nine device malfunctions (2.8%) occurred. Switching into back-up/safety mode and software errors occurred four times each. Once, automatic read-out could not be performed. The median prescribed cumulative dose at planning target volume (PTV) associated with CIED malfunction was 45.0 Gy (IQR 36.0–64.0 Gy), with a median dose per fraction of 2.31 Gy (IQR 2.0–3.0 Gy). The median maximum dose at the CIED at time of malfunction was 0.3 Gy (IQR 0.0–1.3 Gy). No correlation between CIED malfunction and maximum photon energy (p = 0.07), maximum dose at the CIED (p = 0.59) nor treatment localization (p = 0.41) could be detected. After excluding the nine malfunctions, premature battery depletion was only observed three times (1.2%). Depending on the national guidelines, 1–9 CIED malfunctions in this study would have been detected on the day of occurrence and in none of the cases would patient safety have been compromised. Conclusion: Radiation-induced malfunctions of CIEDs and premature battery depletion are rare. If recommendations of national safety guidelines are followed, only a portion of the malfunctions would be detected directly after occurrence. Nevertheless, patient safety would not be compromised.
Air pollution is associated with morbidity and mortality worldwide. We investigated the impact of improved air quality during the economic lockdown during the SARS-Cov2 pandemic on emergency room (ER) admissions in Germany. Weekly aggregated clinical data from 33 hospitals were collected in 2019 and 2020. Hourly concentrations of nitrogen and sulfur dioxide (NO2, SO2), carbon and nitrogen monoxide (CO, NO), ozone (O3) and particulate matter (PM10, PM2.5) measured by ground stations and meteorological data (ERA5) were selected from a 30 km radius around the corresponding ED. Mobility was assessed using aggregated cell phone data. A linear stepwise multiple regression model was used to predict ER admissions. The average weekly emergency numbers vary from 200 to over 1600 cases (total n = 2,216,217). The mean maximum decrease in caseload was 5 standard deviations. With the enforcement of the shutdown in March, the mobility index dropped by almost 40%. Of all air pollutants, NO2 has the strongest correlation with ER visits when averaged across all departments. Using a linear stepwise multiple regression model, 63% of the variation in ER visits is explained by the mobility index, but still 6% of the variation is explained by air quality and climate change.
Psychosocial factors affect mental health and health-related quality of life (HRQL) in a complex manner, yet gender differences in these interactions remain poorly understood. We investigated whether psychosocial factors such as social support and personal and work-related concerns impact mental health and HRQL differentially in women and men during the first year of the COVID-19 pandemic. Between June and October 2020, the first part of a COVID-19-specific program was conducted within the “Characteristics and Course of Heart Failure Stages A-B and Determinants of Progression (STAAB)” cohort study, a representative age- and gender-stratified sample of the general population of Würzburg, Germany. Using psychometric networks, we first established the complex relations between personal social support, personal and work-related concerns, and their interactions with anxiety, depression, and HRQL. Second, we tested for gender differences by comparing expected influence, edge weight differences, and stability of the networks. The network comparison revealed a significant difference in the overall network structure. The male (N = 1370) but not the female network (N = 1520) showed a positive link between work-related concern and anxiety. In both networks, anxiety was the most central variable. These findings provide further evidence that the complex interplay of psychosocial factors with mental health and HRQL decisively depends on gender. Our results are relevant for the development of gender-specific interventions to increase resilience in times of pandemic crisis.
Long-term sequelae in hospitalized Coronavirus Disease 2019 (COVID-19) patients may result in limited quality of life. The current study aimed to determine health-related quality of life (HRQoL) after COVID-19 hospitalization in non-intensive care unit (ICU) and ICU patients. This is a single-center study at the University Hospital of Wuerzburg, Germany. Patients eligible were hospitalized with COVID-19 between March 2020 and December 2020. Patients were interviewed 3 and 12 months after hospital discharge. Questionnaires included the European Quality of Life 5 Dimensions 5 Level (EQ-5D-5L), patient health questionnaire-9 (PHQ-9), the generalized anxiety disorder 7 scale (GAD-7), FACIT fatigue scale, perceived stress scale (PSS-10) and posttraumatic symptom scale 10 (PTSS-10). 85 patients were included in the study. The EQ5D-5L-Index significantly differed between non-ICU (0.78 ± 0.33 and 0.84 ± 0.23) and ICU (0.71 ± 0.27; 0.74 ± 0.2) patients after 3- and 12-months. Of non-ICU 87% and 80% of ICU survivors lived at home without support after 12 months. One-third of ICU and half of the non-ICU patients returned to work. A higher percentage of ICU patients was limited in their activities of daily living compared to non-ICU patients. Depression and fatigue were present in one fifth of the ICU patients. Stress levels remained high with only 24% of non-ICU and 3% of ICU patients (p = 0.0186) having low perceived stress. Posttraumatic symptoms were present in 5% of non-ICU and 10% of ICU patients. HRQoL is limited in COVID-19 ICU patients 3- and 12-months post COVID-19 hospitalization, with significantly less improvement at 12-months compared to non-ICU patients. Mental disorders were common highlighting the complexity of post-COVID-19 symptoms as well as the necessity to educate patients and primary care providers about monitoring mental well-being post COVID-19.
Highlights
• Loss of DNAJC19's DnaJ domain disrupts cardiac mitochondrial structure, leading to abnormal cristae formation in iPSC-CMs.
• Impaired mitochondrial structures lead to an increased mitochondrial respiration, ROS and an elevated membrane potential.
• Mutant iPSC-CMs show sarcomere dysfunction and a trend to more arrhythmias, resembling DCMA-associated cardiomyopathy.
Background
Dilated cardiomyopathy with ataxia (DCMA) is an autosomal recessive disorder arising from truncating mutations in DNAJC19, which encodes an inner mitochondrial membrane protein. Clinical features include an early onset, often life-threatening, cardiomyopathy associated with other metabolic features. Here, we aim to understand the metabolic and pathophysiological mechanisms of mutant DNAJC19 for the development of cardiomyopathy.
Methods
We generated induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) of two affected siblings with DCMA and a gene-edited truncation variant (tv) of DNAJC19 which all lack the conserved DnaJ interaction domain. The mutant iPSC-CMs and their respective control cells were subjected to various analyses, including assessments of morphology, metabolic function, and physiological consequences such as Ca\(^{2+}\) kinetics, contractility, and arrhythmic potential. Validation of respiration analysis was done in a gene-edited HeLa cell line (DNAJC19tv\(_{HeLa}\)).
Results
Structural analyses revealed mitochondrial fragmentation and abnormal cristae formation associated with an overall reduced mitochondrial protein expression in mutant iPSC-CMs. Morphological alterations were associated with higher oxygen consumption rates (OCRs) in all three mutant iPSC-CMs, indicating higher electron transport chain activity to meet cellular ATP demands. Additionally, increased extracellular acidification rates suggested an increase in overall metabolic flux, while radioactive tracer uptake studies revealed decreased fatty acid uptake and utilization of glucose. Mutant iPSC-CMs also showed increased reactive oxygen species (ROS) and an elevated mitochondrial membrane potential. Increased mitochondrial respiration with pyruvate and malate as substrates was observed in mutant DNAJC19tv HeLa cells in addition to an upregulation of respiratory chain complexes, while cellular ATP-levels remain the same. Moreover, mitochondrial alterations were associated with increased beating frequencies, elevated diastolic Ca\(^{2+}\) concentrations, reduced sarcomere shortening and an increased beat-to-beat rate variability in mutant cell lines in response to β-adrenergic stimulation.
Conclusions
Loss of the DnaJ domain disturbs cardiac mitochondrial structure with abnormal cristae formation and leads to mitochondrial dysfunction, suggesting that DNAJC19 plays an essential role in mitochondrial morphogenesis and biogenesis. Moreover, increased mitochondrial respiration, altered substrate utilization, increased ROS production and abnormal Ca\(^{2+}\) kinetics provide insights into the pathogenesis of DCMA-related cardiomyopathy.
Background
Guideline-directed medical therapy (GDMT) is the cornerstone in the treatment of patients with heart failure and reduced ejection fraction (HFrEF) and novel substances such as sacubitril/valsartan (S/V) and sodium-glucose co-transporter-2 inhibitors (SGLT2i) have demonstrated marked clinical benefits. We investigated their implementation into real-world HF care in Germany before, during, and after the COVID-19 pandemic period.
Methods
The IQVIA LRx data set is based on ∼80% of 73 million people covered by the German statutory health insurance. Prescriptions of S/V were used as a proxy for HFrEF. Time trends were analysed between Q1/2016 and Q2/2023 for prescriptions for S/V alone and in combination therapy with SGLT2i.
Findings
The number of patients treated with S/V increased from 5260 in Q1/2016 to 351,262 in Q2/2023. The share of patients with combination therapy grew from 0.6% (29 of 5260) to 14.2% (31,128 of 219,762) in Q2/2021, and then showed a steep surge up to 54.8% (192,429 of 351,262) in Q2/2023, coinciding with the release of the European Society of Cardiology (ESC) guidelines for HF in Q3/2021. Women and patients aged >80 years were treated less often with combined therapy than men and younger patients. With the start of the COVID-19 pandemic, the number of patients with new S/V prescriptions dropped by 17.5% within one quarter, i.e., from 26,855 in Q1/2020 to 22,145 in Q2/2020, and returned to pre-pandemic levels only in Q1/2021.
Interpretation
The COVID-19 pandemic was associated with a 12-month deceleration of S/V uptake in Germany. Following the release of the ESC HF guidelines, the combined prescription of S/V and SGLT2i was readily adopted. Further efforts are needed to fully implement GDMT and strengthen the resilience of healthcare systems during public health crises.
Die Aortenklappenstenose stellt eine der häufigsten Herzklappenerkrankungen der westlichen Welt mit steigender Inzidenz dar. Mithilfe der kathetergestützten Aortenklappenimplantation (TAVI) ist es heutzutage möglich, auch chirurgisch inoperable PatientInnen mit einer Klappenprothese zielgerichtet zu behandeln. Ziel dieser Arbeit war es, klinische und echokardiografische Prädiktoren der Gesamtmortalität sowie des Kurz- (30 Tage) und Langzeitüberlebens (12 Monate) nach TAVI zu ermitteln.
Es wurden zahlreiche klinische und echokardiografische Parameter bei 618 PatientInnen, die zwischen Juli 2009 und Oktober 2018 eine TAVI erhielten, untersucht. Anschließend erfolgte ein Follow-up mittels Telefoninterview oder hausärztlicher Auskunft. Es folgten statistische Analysen zur Ermittlung signifikanter Unterschiede zwischen verstorbenen und lebenden PatientInnen. Abschließend wurden mögliche Prädiktoren der Mortalität mithilfe multivariabler Cox Regressionmodelle identifiziert.
In den Analysen ergaben sich zahlreiche signifikante Unterschiede zwischen Lebenden und Verstorbenen. Klinische Prädiktoren, die ein höheres Risiko der Gesamt- sowie Langzeitmortalität anzeigen, sind der Zugangsweg (transapikal), pAVK, Vorhofflimmern, erhöhte CRP-Level sowie eine Amiodaroneinnahme. Letztere erwies sich als der einzige Prädiktor der Kurzzeitmortalität. Als echokardiografische Prädiktoren (nach Adjustierung bezüglich klinischer Parameter) der Gesamtmortalität präsentieren sich eine erniedrigte TAPSE (≤14mm), erniedrigte septale MAPSE (≤6mm) sowie erhöhtes septales E/e‘ (≥28). Dieses ist auch ein Prädiktor des Lang- und Kurzzeitüberlebens. Zusätzlich zeigt ein sPAP-Anstieg pro 5mmHg eine erhöhte Kurzzeitsterblichkeit an.
Für die Mortalität nach einem TAVI-Eingriff sind neben kardiovaskulären Komorbiditäten auch echokardiografisch messbare kardiale Faktoren entscheidend, insbesondere eine systolische Dysfunktion (erniedrigte TAPSE und MAPSE), diastolische Dysfunktion (erhöhter Füllungsdruckindex E/e‘) sowie erhöhte pulmonalarterielle Drücke (sPAP). Wenn PatientInnen schon vor dem Eingriff diese pathologischen Werte zeigen, sind sie als einem „Hochrisikokollektiv“ zugehörig aufzufassen, was in der Aufklärung wie auch Vor- und in der Nachsorge solcher PatientInnen zukünftig Berücksichtigung finden sollte.
Der kathetergestützte Aortenklappenersatz nimmt auch bei Patienten mit niedrigem OP-Risiko einen zunehmend größeren Stellenwert zur Behandlung der hochgradigen Aortenklappenstenose ein.45 Umso wichtiger ist es, die einzelnen Schritte der Intervention zu optimieren. In einigen Arbeiten wurde bereits die Vordilatation als obsolet bezeichnet, da sie lediglich die OP-Zeit verlängere und Komplikationen wie Schlaganfälle und AV-Blockierungen begünstige.22,52,53,57,59 Ziel dieser Studie war es, die Vor- und Nachteile der Vordilatation zu untersuchen. Hierzu wurden 625 Patienten, die im Zeitraum von 2016-2020 eine TAVI am UKW erhielten, retrospektiv analysiert (323 mit, 302 ohne Vordilatation). Es wurden demographische sowie prä-, peri- und post-interventionelle Daten analysiert. Statistisch signifikante Unterschiede wurden bei den Schlaganfällen beobachtet (p=0,01), die mit 2,2% lediglich bei Patienten mit Vordilatation auftraten, sodass bei einem hohen Schlaganfallrisiko hierauf verzichtet werden sollte. Zusätzlich war in der Gruppe mit Vordilatation die passagere Schrittmacherabhängigkeit signifikant häufiger (p=0,01). Alle anderen Komplikationen waren nicht signifikant. In beiden Gruppen zeigte sich zu >95% ein Device-Success, sodass der Verzicht auf eine Prädilatation nicht mit einem schlechteren Outcome assoziiert und somit sicher ist.53,57,58,59,61
Die Auswertung der TTE-Daten zeigte, dass eine Prädilatation durchgeführt wurde, wenn die Klappe signifikant höhergradig stenosiert war (Pmean 50,17 vs. 46,79mmHG). Ferner wurde bei leichtgradigen Aortenklappeninsuffizienzen signifikant häufiger auf eine Vordilatation verzichtet (p=0,04). Eine Vordilatation kann also bei komplexeren anatomischen Verhältnissen sinnvoll sein, um einen optimalen Klappensitz zu gewährleisten.52,53 Nach TAVI zeigte sich die LV-EF in der Gruppe mit Prädilatation signifikant höher (p=0,002). Höhergradige Aortenklappeninsuffizienzen scheinen nicht durch eine Vordilatation begünstigt zu sein, die AI°II wurde nur bei 4 Patienten ohne Vordilatation beobachtet. In den postinterventionellen EKG-Daten zeigten sich in der Gruppe ohne Vordilatation signifikant häufiger Linksschenkelblöcke sowie ein AVB °II, Typ II, was vermutlich durch die fehlende Vorbereitung der Klappe und den damit assoziierten ungünstigeren Prothesensitz zu erklären ist.53 Die Nachdilatation wurde nicht durch eine vorausgegangene Vordilatation beeinflusst. Bezüglich der implantierten Klappenarten wurde die S3 Ultra signifikant häufiger bei Patienten ohne Vordilatation eingesetzt. Die in vielen Arbeiten beschriebene kürzere OP-Dauer ließ sich in dieser Studie nicht bestätigen.52,53,56 Stattdessen war bei TAVIs ohne Vordilatation die Eingriffsdauer im Schnitt 4min länger (p=0,11). Es bestätigte sich, dass bei einer Prädilatation signifikant mehr Kontrastmittel verwendet wurde (p=0,001) und die Strahlenbelastung höher war. Dies ist insbesondere für Patienten mit einer Niereninsuffizienz von Bedeutung.42 Ob eine Vordilatation durchgeführt wird, sollte also individuell aufgrund der Begleiterkrankungen und Risikofaktoren entschieden werden.
A growing body of literature reports on the upregulation of C-X-C motif chemokine receptor 4 (CXCR4) in a variety of cancer entities, rendering this receptor as suitable target for molecular imaging and endoradiotherapy in a theranostic setting. For instance, the CXCR4-targeting positron emission tomography (PET) agent [\(^{68}\)Ga]PentixaFor has been proven useful for a comprehensive assessment of the current status quo of solid tumors, including adrenocortical carcinoma or small-cell lung cancer. In addition, [\(^{68}\)Ga]PentixaFor has also provided an excellent readout for hematological malignancies, such as multiple myeloma, marginal zone lymphoma, or mantle cell lymphoma. PET-based quantification of the CXCR4 capacities in vivo allows for selecting candidates that would be suitable for treatment using the theranostic equivalent [\(^{177}\)Lu]/[\(^{90}\)Y]PentixaTher. This CXCR4-directed theranostic concept has been used as a conditioning regimen prior to hematopoietic stem cell transplantation and to achieve sufficient anti-lymphoma/-tumor activity in particular for malignant tissues that are highly sensitive to radiation, such as the hematological system. Increasing the safety margin, pretherapeutic dosimetry is routinely performed to determine the optimal activity to enhance therapeutic efficacy and to reduce off-target adverse events. The present review will provide an overview of current applications for CXCR4-directed molecular imaging and will introduce the CXCR4-targeted theranostic concept for advanced hematological malignancies.
Background: Large Cell Neuroendocrine Carcinoma (LCNEC) is a rare subtype of lung cancer with poor clinical outcomes. Data on recurrence-free survival (RFS) in early and locally advanced pure LCNEC after complete resection (R0) are lacking. This study aims to evaluate clinical outcomes in this subgroup of patients and to identify potential prognostic markers. Methods: Retrospective multicenter study including patients with pure LCNEC stage I-III and R0 resection. Clinicopathological characteristics, RFS, and disease-specific survival (DSS) were evaluated. Univariate and multivariate analyses were performed. Results: 39 patients (M:F = 26:13), with a median age of 64 years (44–83), were included. Lobectomy (69.2%), bilobectomy (5.1%), pneumonectomy (18%), and wedge resection (7.7%) were performed mostly associated with lymphadenectomy. Adjuvant therapy included platinum-based chemotherapy and/or radiotherapy in 58.9% of cases. After a median follow-up of 44 (4–169) months, the median RFS was 39 months with 1-, 2- and 5-year RFS rates of 60.0%, 54.6%, and 44.9%, respectively. Median DSS was 72 months with a 1-, 2- and 5-year rate of 86.8, 75.9, and 57.4%, respectively. At multivariate analysis, age (cut-off 65 years old) and pN status were independent prognostic factors for both RFS (HR = 4.19, 95%CI = 1.46–12.07, p = 0.008 and HR = 13.56, 95%CI 2.45–74.89, p = 0.003, respectively) and DSS (HR = 9.30, 95%CI 2.23–38.83, p = 0.002 and HR = 11.88, 95%CI 2.28–61.84, p = 0.003, respectively). Conclusion: After R0 resection of LCNEC, half of the patients recurred mostly within the first two years of follow-up. Age and lymph node metastasis could help to stratify patients for adjuvant therapy.
Das adrenokortikale Karzinom (ACC) ist eine seltene Tumorerkrankung der Nebennierenrinde. Die Prognose ist im Allgemeinen ungünstig und vom Tumorstadium sowie von weiteren tumor- und patientenspezifischen Faktoren abhängig. Die chirurgische Komplettresektion stellt das bisher einzige kurative Behandlungsverfahren dar.
Dabei gibt es bisher für sonstige Lokaltherapien beim fortgeschrittenen bzw. rezidivierten ACC kaum umfangreiche Daten, welche die entsprechende lokale Wirksamkeit belegen. Neben der Operation stellt die Strahlentherapie eine bisher effektive Therapieoption bei verschiedenen anderen Tumorerkrankungen hinsichtlich Tumorkontrolle, Verträglichkeit und Zugänglichkeit dar. Allerdings ist diese Option in der Behandlung des fortgeschrittenen ACC als Lokaltherapie bislang nicht mit zufriedenstellenden Datensätzen umfänglich untersucht.
Ziel dieser Studie war es, anhand einer retrospektiven Datenanalyse aus dem European Network for the Study of Adrenal Tumours (ENSAT) den Stellenwert der Strahlentherapie als Lokaltherapie beim fortgeschrittenen bzw. rezidivierten ACC zu untersuchen. Es wurden insgesamt 132 Fälle hinsichtlich strahlentherapeutischer Dosis, Lokalkontrolle, progressionsfreiem Überleben, Gesamtüberleben, objektivem Ansprechen, Verträglichkeit und Risikofaktoren untersucht.
Hierbei konnte gezeigt werden, dass die Anwendung einer hohen biologischen Effektivdosis mit einer verbesserten lokalen Tumorkontrolle einhergeht. Insgesamt zeigte sich eine gute Verträglichkeit der strahlentherapeutischen Behandlung. Die Ergebnisse dieser Arbeit legen nahe, dass wahrscheinlich weitere Risikofaktoren mit Rezidiven dieser Tumorart einhergehen, allerdings weitere Untersuchungen (z.B. randomisierte prospektive Studien) erfordern. Letztendlich stellt diese Arbeit auch die angewandten Dosis- und Fraktionierungskonzepte der vergangenen Jahrzente bei der Behandlung des ACC dar.