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- 1991 (1)
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- Englisch (1) (entfernen)
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- glycosyl phosphatidyl-inostitols. (1) (entfernen)
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- Institut für Molekulare Infektionsbiologie (1) (entfernen)
The major macromolecule on the surface o/Leishmania majorpromastigotes is a lipophosphoglycan (LPG). This glycoconjugate plays a key role in determining infectivity and survival of para-sites in the mammalian host cell. In addition, L. major LPG is able to induce a host-protective immune response. In this article, we summarise the evidence for recognition of highly purified LPG by T cells and we discuss the potential mechanisms of T-cell Stimulation by this non-protein antigen.