Refine
Has Fulltext
- yes (445) (remove)
Is part of the Bibliography
- yes (445)
Year of publication
- 2014 (445) (remove)
Document Type
- Journal article (445) (remove)
Keywords
- gene expression (12)
- expression (10)
- apoptosis (6)
- cancer (6)
- escherichia coli (6)
- flow cytometry (6)
- disease (5)
- gene (5)
- immune response (5)
- in-vitro (5)
- lymphoma (5)
- metabolism (5)
- mice (5)
- phosphorylation (5)
- protein (5)
- Germany (4)
- activation (4)
- antibodies (4)
- blood pressure (4)
- body mass index (4)
- brain (4)
- breast cancer (4)
- cancer treatment (4)
- cell staining (4)
- cells (4)
- children (4)
- cytokines (4)
- cytoskeleton (4)
- immunoprecipitation (4)
- in-vivo (4)
- infection (4)
- inflammation (4)
- ischemic stroke (4)
- messenger RNA (4)
- molecular docking (4)
- oxidative stress (4)
- platelets (4)
- proliferation (4)
- stroke (4)
- survival (4)
- traumatic brain injury (4)
- B cells (3)
- EEG (3)
- ERP (3)
- Echinococcus (3)
- MRI (3)
- NF-KAPPA-B (3)
- T cells (3)
- amyotrophic-lateral-sclerosis (3)
- analysis of variance (3)
- asthma (3)
- bacteria (3)
- biodiversity (3)
- blood (3)
- blood flow (3)
- burden (3)
- crystal structure (3)
- dendritic cells (3)
- diet (3)
- drosophila melanogaster (3)
- efficacy (3)
- epithelial cells (3)
- evidence-based medicine (3)
- evolution (3)
- fMRI (3)
- food-cues (3)
- genome (3)
- growth (3)
- guidelines (3)
- indication for surgery (3)
- kidneys (3)
- laparoscopic ventral hernia repair (3)
- metastasis (3)
- microarray (3)
- neurons (3)
- neuropathic pain (3)
- obesity (3)
- perioperative management (3)
- platelet activation (3)
- platelet aggregation (3)
- positron emission tomography (3)
- protein domains (3)
- rat (3)
- reveals (3)
- stress (3)
- therapy (3)
- virulence (3)
- ADHD (2)
- Akt (2)
- Autonomous UAV (2)
- B-cells (2)
- DAPI staining (2)
- Depression (2)
- ELISPOT (2)
- Gibbs free energy of binding (2)
- HIV (2)
- HNSCC (2)
- Hfq (2)
- LASP1 (2)
- MS (2)
- Medizin (2)
- Merkel cell carcinoma (2)
- Multiple myeloma (2)
- NET (2)
- Neisseria meningitidis (2)
- Neurodegeneration (2)
- PRRT (2)
- Parkinson's disease (2)
- Parkinsons disease (2)
- RNA extraction (2)
- RNA-SEQ (2)
- RapidEye (2)
- Rhabdomyosarcoma (2)
- Rituximab (2)
- TerraSAR-X (2)
- Trypanosoma brucei (2)
- absolute configuration (2)
- accelerometer (2)
- actins (2)
- adults (2)
- aging (2)
- angiogenesis (2)
- antigenic variation (2)
- ants (2)
- anxiety (2)
- aorta (2)
- apis mellifera (2)
- archaea (2)
- aspergillus fumigatus (2)
- autophagy (2)
- bees (2)
- binding (2)
- bioactivity (2)
- biological locomotion (2)
- biological sciences (2)
- biomarker (2)
- biomarkers (2)
- biosynthesis (2)
- blood-brain barrier (2)
- body weight (2)
- carbohydrates (2)
- carcinomas (2)
- cell cultures (2)
- central nervous system (2)
- chemokines (2)
- chemotherapy (2)
- chronic kidney disease (2)
- clothing (2)
- communication (2)
- comparative genomics (2)
- complex (2)
- consciousness (2)
- crosstalk (2)
- culture (2)
- cytotoxic T cells (2)
- death rates (2)
- density functional theory (2)
- depression (2)
- dereplication (2)
- diagnostic medicine (2)
- dieting success (2)
- dopamine (2)
- down regulation (2)
- drug delivery (2)
- echocardiography (2)
- ecology (2)
- electronic structure (2)
- energy metabolism (2)
- enzyme-linked immunoassays (2)
- epidemiology (2)
- epigenetics (2)
- event-related potentials (2)
- factor XII (2)
- factor-I (2)
- follicular lymphoma (2)
- follow-up (2)
- foraging (2)
- fungal structure (2)
- fungi (2)
- gait (2)
- games (2)
- gastric cancer (2)
- gene regulation (2)
- genes (2)
- glioma (2)
- glycolysis (2)
- green fluorescent protein (2)
- gyroscope (2)
- heart (2)
- hospitalizations (2)
- humans (2)
- hypertension (2)
- identification (2)
- immunohistochemistry techniques (2)
- inhibition (2)
- inhibitors (2)
- integrins (2)
- lipid bilayer (2)
- lung and intrathoracic tumors (2)
- lymphocytes (2)
- macrophages (2)
- man-computer interface (2)
- management (2)
- meiosis (2)
- melanoma (2)
- membrane (2)
- membrane proteins (2)
- messenger-RNA (2)
- miRNA (2)
- midazolam (2)
- model (2)
- multiple sclerosis (2)
- mutations (2)
- necrosis-factor-alpha (2)
- nervous system (2)
- oncolytic viruses (2)
- opioids (2)
- organization (2)
- oscillation (2)
- outbreak (2)
- ovarian cancer (2)
- oxygen uptake (2)
- oxygenation (2)
- panic disorder (2)
- perception (2)
- phylogenetic analysis (2)
- phylogenetic trees (2)
- plasmodium falciparum (2)
- pollination (2)
- polyneuropathy (2)
- poor prognosis (2)
- population (2)
- prediction (2)
- predictive value (2)
- prognosis (2)
- progression (2)
- prostate cancer (2)
- protein aggregation (2)
- protein-protein interactions (2)
- proteins (2)
- pulmonary hypertension (2)
- quality (2)
- recruitment (2)
- regulatory T cells (2)
- relapse (2)
- renal cancer (2)
- replication (2)
- resistance (2)
- responses (2)
- risk (2)
- risk factors (2)
- saccharomyces cerevisiae (2)
- scanning electron microscopy (2)
- secondary lung tumors (2)
- secretion (2)
- sepsis (2)
- sequence (2)
- sequence alignment (2)
- sex chromosomes (2)
- small interfering RNAs (2)
- solar cells (2)
- spin–orbit coupling (2)
- sponges (2)
- staphylococcus aureus (2)
- stem-cell transplantation (2)
- strains (2)
- stress resistance (2)
- stromal cells (2)
- superconductivity (2)
- surgical oncology (2)
- susceptibility (2)
- synaptic plasticity (2)
- target (2)
- telomeres (2)
- textile (2)
- time series (2)
- tissue saturation index (2)
- topological insulators (2)
- transcription (2)
- transcription factors (2)
- transcriptome (2)
- transcriptomics (2)
- transplantation (2)
- tumor (2)
- type 2 diabetes (2)
- tyrosine (2)
- ubiquitination (2)
- validation (2)
- venous system (2)
- video analysis (2)
- weight loss (2)
- young children (2)
- "-omics" (1)
- 18-F-fluorothymidine uptake (1)
- 18FDG-PET/CT (1)
- 2 PM (1)
- 2-APB (1)
- 3D models (1)
- 3′ UTR (1)
- 5-Fluorouracil (1)
- 5-HT1A receptor (1)
- 5-bromodeoxyuridine (1)
- 5IA-SPECT (1)
- 60-nucleotide duplication (1)
- A-D (1)
- AAPA (1)
- ABL gene (1)
- ACH-2 (1)
- AG(110) (1)
- ALCL (1)
- ALS (1)
- ARF tumor-suppressor induced lymphomagenes (1)
- ARPES (1)
- ART outcome (1)
- ATG (1)
- ATG8 (1)
- ATM gene (1)
- ATP-binding cassette transporter (1)
- AVHRR (1)
- AVHRR data (1)
- Accelerometry (1)
- Actinokineospora (1)
- Action feedback (1)
- Adult (1)
- African Trypanosomes (1)
- Aktien (1)
- Alkaline phosphatase (1)
- Allophrynidae (1)
- Amu Darya (1)
- Analgesia (1)
- Anaphylaxis (1)
- Angst (1)
- Anticoagulants (1)
- Anura (1)
- Apoptosis (1)
- Arginine (1)
- Argonaute (1)
- Arterial Diameters (1)
- Aseptic loosening (1)
- Association (1)
- Astrocytic tumor (1)
- Auslandsgesellschaft (1)
- B cell receptors (1)
- BCL-X-L P53 (1)
- BCR-ABL (1)
- BDNF (1)
- BETA(2)-adrenergic receptor (1)
- BH3-only proteins (1)
- BTN3 (1)
- Baltic Sea (1)
- Barbed suture (1)
- Barbed suture material (1)
- Benzimidazoles (1)
- Berger-Parker (1)
- Bevacizumab (1)
- Bewertung (1)
- Bias (1)
- Bibel. Judit (1)
- Bibliometrie (1)
- Biomarker (1)
- Bipolar disorder (1)
- Bisphosphonates (1)
- Bombus (1)
- Bombus Spp. Hymenoptera (1)
- Bone regeneration (1)
- Bone tumor (1)
- Brain (1)
- Brain-computer interface (1)
- Brassica napus (1)
- Breast cancer cells (1)
- Bumblebee (1)
- Burma (1)
- C(-1019)G polymorphism (1)
- C-13-metabolic flux analysis (1)
- C-MYC (1)
- C-MYC PUMA (1)
- C-Terminus (1)
- C1-inhibitor (1)
- C57BL/6 mice (1)
- C6 (1)
- CASP (1)
- CASPASE-3 (1)
- CCD (1)
- CCDC79 (1)
- CCN1 (1)
- CD coreceptors (1)
- CD/metabolism (1)
- CD20 (1)
- CD27 (1)
- CD39 (1)
- CD4(+) (1)
- CD4(+) T-cells (1)
- CD40 (1)
- CD40 ligand (1)
- CD40L (1)
- CD46 (1)
- CD70 (1)
- CD73 (1)
- CD8(+) (1)
- CLAVATA3 (1)
- CLEC-2 ITAM (1)
- CML (1)
- CNS Myelination (1)
- CNVs (1)
- COMPLEX 1 (1)
- CRKL (1)
- CSVD (1)
- CYP2W1 (1)
- Ca2+ release activated Ca2+ channel (1)
- Cancer treatment (1)
- Candidate Phylum Poribacteria (1)
- Caspase 3/7 activity (1)
- Catechine (1)
- Cav2.2 (1)
- Cell viability, (1)
- Central Asia (1)
- Central venous access (1)
- Centrolenidae (1)
- Cestoda (1)
- Cestode (1)
- Charcot-Marie-Tooth disease (1)
- Chemotherapy (1)
- China (1)
- Chirurgie (1)
- Chondrosarcoma (1)
- Chronic disease (1)
- Chronic kidney disease (1)
- Climate Change (1)
- Coagulation factor IX (1)
- Coexpression (1)
- Combination therapy (1)
- Computertomographie (1)
- Cooperative UAV (1)
- Copy number variation (1)
- Correlates (1)
- Costa Rica (1)
- Coumarin (1)
- Crohns-disease (1)
- Cross-species analyses (1)
- CsrA (1)
- Cushing’s syndrome (1)
- Cyclophosphamide (1)
- Cytokines (1)
- D insufficiency (1)
- D serum-levels (1)
- DEL(5Q) (1)
- DETC (1)
- DHAP (1)
- DLBCL (1)
- DLX5/6 (1)
- DM-domain gene (1)
- DNA (1)
- DNA damage (1)
- DNA glycosation (1)
- DNA methylation (1)
- DNA methyltransferase gene (1)
- DNA repair (1)
- DNA repair protraction (1)
- DNA-binding domain (1)
- DNA-binding proteins (1)
- DNA-damage checkpoint (1)
- DNMT3A (1)
- DNMT3B (1)
- DOPA-responsive-dystonia (1)
- DSM-5 (1)
- DSM-IV (1)
- DWI (1)
- DYNC1I1 (1)
- Data Fusion (1)
- Der Granatapfelbaum (1)
- Diels–Alder reaction (1)
- Differential GPS (DGPS) (1)
- Directed Flight (1)
- Distributed Control (1)
- Domain-specific approach (1)
- Drought (1)
- Drug allergy (1)
- Drug reaction (1)
- Dynamic stopping (1)
- Dyson orbitals (1)
- EBM (1)
- EGFR (1)
- ERCC1-XPF (1)
- ERCC4 (1)
- ERK signaling cascade (1)
- ERM proteins (1)
- ERPs (1)
- ESM (1)
- Echinococcosis (1)
- Ectopic bone formation (1)
- Einfluss (1)
- Endogenous opioids (1)
- Entwicklung (1)
- EpCAM (1)
- Ernährung (1)
- Erwinia amylovora (1)
- Escherichia coli infections (1)
- Escherichia coli-Hfq (1)
- Escherichia coli-derived recombinant human bone morphogenetic protein-2 (1)
- Europe (1)
- Europäische Grundfreiheiten (1)
- Evaluation (1)
- Event-related potentials (1)
- Exercise testing (1)
- Explorative analyses (1)
- Expression (1)
- Extraocular eye muscles (1)
- FADD (1)
- FANCP (1)
- FDG-PET (1)
- FDG-PET/CT (1)
- FISH (1)
- FLS2 receptor (1)
- FLT-PET (1)
- FMRI (1)
- FNIRS (1)
- FOSMN (1)
- Fabry disease (1)
- Fbw7 (1)
- Fibromyalgia syndrome (1)
- Flexor tendon repair (1)
- Food Carvings Questionnaire (1)
- Food Cravings Questionnaires (1)
- Food craving (1)
- Franz von Kutschera (1)
- French-Canadian patients (1)
- G protein-coupled receptor (1)
- GAAS (1)
- GCH1 (1)
- GFP (1)
- GH response (1)
- GLV-1 h153 (1)
- GPS Reciever (1)
- GTL2 (1)
- GUT (1)
- GVHD (1)
- GWAS (1)
- Gecko (1)
- Gene sets (1)
- Generic questionnaire (1)
- Genotype-phenotype association (1)
- Germinative cell (1)
- Glatiramer acetate (1)
- Glioblastoma (1)
- Glioblastoma cell line (1)
- Glioblastoma multiforme (1)
- Global Navigation Satellite System (GNSS) (1)
- Global Positioning System (GPS) (1)
- Grasses (1)
- Graves disease (1)
- Guillain-Barre-Syndrome (1)
- HCV genotype-2 (1)
- HER2 (1)
- HERV-K (1)
- HIP osteoarthritis (1)
- HIV-1 protease (1)
- HUWE1 (1)
- Halothane (1)
- HeLa cells (1)
- Head (1)
- Health promotion (1)
- Health-determinants (1)
- Herbivory (1)
- Herzthoraxchirurgie (1)
- Hesse (1)
- Hickman catheter (1)
- High-fat diet (1)
- Hill's powers (1)
- Hirschsprung disease (1)
- Hochmittelalter (1)
- Honeybee (1)
- Host-parasite interaction (1)
- Host-pathogen interactions (1)
- Hubbard model (1)
- Hubbard-model (1)
- Human endogenous retrovirus (1)
- Hypercortisolism (1)
- Hyperkalaemia (1)
- Hypopharyngeal glands (1)
- I-lactate (1)
- I-tasser (1)
- ICF2 (1)
- ICL (1)
- ICSI (1)
- IGF-I (1)
- IGF1 (1)
- II citrullinemia (1)
- IL28B polymorphisms (1)
- IMSI (1)
- ITS2 (1)
- IctP (1)
- Ighmbp2 (1)
- Immunohistochemistry (1)
- Immunosuppression (1)
- Impact-Faktor (1)
- Improved survival (1)
- Inflammation (1)
- Inflammatory pain (1)
- Insects (1)
- Insulin (1)
- Interference microscopy (1)
- Interleukin-2 (1)
- Interleukin-5 (1)
- Intravital imaging (1)
- Iowa Gambling Task (1)
- Irradiation (1)
- Kaiser test (1)
- Kaposi sarcoma (1)
- Kenyon cells (1)
- Kidney cancer (1)
- Kinase inhibitor (1)
- Knotless tendon repair (1)
- Konzerninsolvenzrecht (1)
- Kunstgeschichte (1)
- L-3,4-Dihydroxyphenylalanine-induced dyskinesia (1)
- LAALO3/SRTIO3 interfaces (1)
- LCST (1)
- LNCaP (1)
- LPS (1)
- Labial glands (1)
- Langlebigkeit (1)
- Larvae (1)
- Laser Doppler vibrometer (1)
- Leaves (1)
- Lebenszyklus (1)
- Legumes (1)
- Leishmania (1)
- Leptin (1)
- Longitudinal analysis (1)
- Low-fat diet (1)
- Lung cancer (1)
- Lysine (1)
- Lysosomal storage disease (1)
- MAG3 (1)
- MAPK signaling cascades (1)
- MCL-1 (1)
- MDS (1)
- MFM (1)
- MHC molecules (1)
- MIR-155 (1)
- MIZ1 (1)
- MMN (1)
- MODIS (1)
- MOPC315.BM (1)
- MRI criteria (1)
- MVT (1)
- MYC (1)
- Maintenance treatment (1)
- Malignant hyperthermia (1)
- Mania (1)
- Mastocytosis (1)
- Matlab (1)
- MeDALL (1)
- Measurement invariance (1)
- Medienpädagogik (1)
- Meeresschwämme (1)
- Mesenchymal stem cells (1)
- Metastases (1)
- Mexican coffee plantations (1)
- Microcavity devices (1)
- Mini Unmanned Aerial Vehicle (1)
- Mobile Sensor Network (1)
- Molecular imaging (1)
- Monopolar depression (1)
- Mucin (1)
- Mushroom bodies (1)
- Myanmar (1)
- N400 (1)
- NEIL2 (1)
- NFκB (1)
- NK cells (1)
- NMR (1)
- NMR fingerprint (1)
- NRPS (1)
- NSAIDs (1)
- NTCDA (1)
- NVP-BEZ235 (1)
- NVP-BGT226 (1)
- Nanog protein (1)
- Nanos (1)
- Neanderthal (1)
- Neisseria gonorrhoeae (1)
- Nekrose (1)
- Neoblast (1)
- Neuronal ceroid lipofuscinosis (1)
- Neutrino mass mixing (1)
- New Zealand (1)
- Nfatc1 (1)
- Nogo-A (1)
- Non-steroidal anti-inflammatory drug (1)
- North American (1)
- Northeastern Costa Rica (1)
- Northern Xinjiang (1)
- Novel PI3K (1)
- Novobiocin (1)
- OCD (1)
- OGG1 (1)
- Oct4 (1)
- Oocytes (1)
- Opioid receptor (1)
- Optical coherence tomography (1)
- OxyR (1)
- Oxygen uptake (1)
- P-cresyl sulfate (1)
- P-gp inhibitors (1)
- P300 (1)
- PARK2 (1)
- PCR analysis (1)
- PD-L1 (1)
- PET/CT (1)
- PI3K (1)
- PKS I (1)
- PKS II (1)
- POLSCORE (1)
- PSA (1)
- PSI-blast (1)
- PTCDA (1)
- PTCL (1)
- Pamir (1)
- Parent-of-origin (1)
- Parkinson disease (1)
- Pediatric malignancy (1)
- Perinatal Asphyxia (1)
- Peyer's patches (1)
- Physical activity (1)
- Plant-herbivore interactions (1)
- PolSAR (1)
- Polarity index (1)
- Polylactide-co-glycolide (1)
- Port (1)
- Positioning (1)
- Positron emission tomography (1)
- Predominant polarity (1)
- Probenecid (1)
- Profilierung (1)
- Profiling (1)
- Prognose (1)
- Prognosis (1)
- Pseudo-allergy (1)
- Psychopharmakologie (1)
- Psychotherapie (1)
- Pulse shaping (1)
- QKD (1)
- Quadrocopter (1)
- Quadrotor (1)
- Quality of life (1)
- Qualität (1)
- Quantum-well, -wire and -dot devices (1)
- Questionnaire (1)
- Quetiapine (1)
- RAF1 (1)
- RAS (1)
- RCC (1)
- RDoC (1)
- RFP (1)
- RHO (1)
- RHO-associated kinease (1)
- RINEX Format (1)
- RNA (1)
- RNA CHAPERONE HFQ (1)
- RNA sequence (1)
- RNA splicing (1)
- RNA-SEQ data (1)
- RNA-polymerase-I (1)
- RNA-polymerase-II (1)
- RNA-seq (1)
- RNAseq (1)
- RNS (1)
- ROK-alpha (1)
- RTMS (1)
- Radarsat-2 (1)
- Radium (1)
- Rashba effect (1)
- Receptor kinase (1)
- Rechtsprechung (1)
- Rectal cancer (1)
- Red sea (1)
- Renal cell carcinoma (1)
- Rescorla-Wagner model (1)
- Resonators (1)
- Retest-reliability (1)
- Retinal degeneration (1)
- Rezension (1)
- Rhodobacter sphaeroides (1)
- Ribosom (1)
- Richardson-Olszewski-Syndrome (1)
- Rituximab plus (1)
- Riutximab (1)
- RyR1 mutations (1)
- SAR (1)
- SF-36 (1)
- SGLT-1 (1)
- SGLT2 inhibitor (1)
- SGN-35 (1)
- SGNH hydrolase (1)
- SH-6 (1)
- SHFM (1)
- SHRSP (1)
- SLAM CDW150 (1)
- SLX4 (1)
- SM-like protein (1)
- SMAD signaling (1)
- SMARD1 (1)
- SNP array (1)
- SOCE (1)
- SREBP (1)
- SREC-I (1)
- SRTIO3 (1)
- STAT3 (1)
- SUN1 (1)
- SWI2/SNF2-like protein (1)
- Salmonella-containing vacuole (SCV) (1)
- ScFv (1)
- Scanning microscopy (1)
- Scattering (1)
- Schönheit (1)
- Sedentary behaviour (1)
- Septuaginta (1)
- Sequence motif analysis (1)
- Sex (1)
- Shiga toxin-producing Escherichia coli (1)
- Sitting/standing (1)
- Sjorgens-syndrome (1)
- Skin biopsy (1)
- Skint1 (1)
- SnRK1 (1)
- Somatostatin receptor expression (1)
- South Africa (1)
- SphK1 (1)
- Spheciospongia vagabunda (1)
- Spinal dissemination (1)
- Spindle cell (1)
- Splicing (1)
- Spumaviren (1)
- Src family (1)
- Stem cell (1)
- Stereology (1)
- Strahlenpilze (1)
- Stratafix (1)
- Stroke (1)
- Subwavelength structures (1)
- Succinylcholine (1)
- Supersymmetry (1)
- Surgery (1)
- Swine (1)
- Syr Darya (1)
- Systematic review (1)
- T Cells (1)
- T cell receptors (1)
- T cell silencing (1)
- T-DM1 (1)
- T-antigens (1)
- T-cells (1)
- T6P (1)
- TEM (1)
- TERB1 (1)
- TME (1)
- TNF (1)
- TNF-alpha (1)
- TOR (1)
- TP53 mutations (1)
- TRAIL (1)
- TWEAK (1)
- TYPE-2 (1)
- Tactile (1)
- Tapeworm (1)
- Teamwork (1)
- Temozolomide (1)
- Terminal 4q deletion syndrome (1)
- Thrombosis (1)
- Tian Shan (1)
- Toll like receptors (1)
- Total knee arthroplasty (1)
- Tribolium castaneum (1)
- Tumour markers (1)
- UBZ (1)
- Ultrafast measurements (1)
- United States (1)
- University students (1)
- Unmanned Aerial Vehicle (UAV) (1)
- V-Loc (1)
- VKORC1 (1)
- VOC emissions (1)
- Vaccinia virus (1)
- Vacuum stability (1)
- Valeriana wallichii (1)
- Verbraucherschutzrecht (1)
- Vesicles (1)
- Vision Based (1)
- Vitamin K epoxide reductase (1)
- Voronoi tree map (1)
- Vulgata (1)
- Vγ9Vδ2 T cell (1)
- WNT pathway (1)
- Warfarin (1)
- Warsaw breakage syndrome (1)
- West Africa (1)
- Wheelchair (1)
- Wissenschaftliches Arbeiten (1)
- Xenopus oocytes (1)
- Y chromosome (1)
- Yaşar Kemal (1)
- YoelII-Nigeriensis (1)
- ZBTB24 (1)
- ZBTB24 mutations (1)
- ZW sex chromosomes (1)
- Zeitschrift (1)
- [18F]Fluorodeoxythymidine (1)
- abdominal aortic-aneurysm (1)
- abietane (1)
- abnormalities (1)
- abscisic acid (1)
- abundance (1)
- accumulation (1)
- acetyltransferase RTT109 (1)
- acid dissociation (1)
- acoustic signals (1)
- acrican trypanosomes (1)
- actin (1)
- actin filament (1)
- actinomycetes (1)
- actinosporins (1)
- action (1)
- action ability (1)
- action access (1)
- action and perception (1)
- action effects (1)
- action videogaming (1)
- activated receptor-1 (1)
- activating receptors (1)
- active middle-ear implant (1)
- activity rhythm (1)
- acupuncture (1)
- acute kidney injury (1)
- acute lymphoblastic leukemia (1)
- acute mania (1)
- acute myelogenous leukemia (1)
- acute myeloid-leukemia (1)
- acute watery diarrhea (1)
- adaptation (1)
- adaptive plasticity (1)
- adaptor protein Swiprosin-1/EFhd2 (1)
- add-on (1)
- adenocarcinoma of the lung (1)
- adenosine (1)
- adenylyl cyclase (1)
- adenylyl-cyclase isoforms (1)
- adhesion dynamics (1)
- adhesion molecules (1)
- adoptive transfer (1)
- adrenal glands (1)
- adrenal medulla (1)
- adult cardiac myocytes (1)
- advanced therapy medicinal products (1)
- affective state (1)
- afferents (1)
- affinity (1)
- african trypanosomes (1)
- age (1)
- age groups (1)
- age polyethism (1)
- agriculture (1)
- agroecosystems (1)
- albinaria (1)
- albuminuria (1)
- aldosterone (1)
- algorithm (1)
- alignment (1)
- alignment clustering (1)
- all-cause mortality (1)
- allergic rhinitis (1)
- allergy (1)
- allogeneic hematopoietic stem cell transplantation (1)
- alpaca (1)
- alpha-emitters (1)
- alpha-helical structure (1)
- alpha/delta agonist GFT505 (1)
- ambystoma opacum (1)
- amino acids (1)
- amino groups (1)
- amino-acid-metabolism (1)
- aminocoumarins (1)
- ampa receptors (1)
- amphibian metamorphosis (1)
- amphiphilic poly(2-oxazoline)s (1)
- amplifications (1)
- amygdala (1)
- amyloidosis (1)
- amyotrophic lateral sclerosis (1)
- anaesthetics (1)
- analgesia (1)
- anaplastic large cell lymphoma (ALCL) (1)
- angle resolved photo emission spectroscopy (1)
- angle-resolved photoemission spectroscopy (1)
- anguage and word processing (1)
- anhedonia (1)
- animal behavior (1)
- animal model (1)
- animal models (1)
- ankles (1)
- annecin-V (1)
- annotation (1)
- anorexia nervosa (1)
- ant (1)
- anthocyanin derivatives (1)
- anti-CD30 drug conjugate (1)
- anti-trypanosoma (1)
- anticipation (1)
- antifungal agents (1)
- antifungals (1)
- antigenetic variation (1)
- antigens (1)
- antiretroviral therapy (1)
- antisense RNA (1)
- antisense RNAs (1)
- antitumor immunity (1)
- anxiety disorders (1)
- apical GLUT2 (1)
- applied physics (1)
- approximation (1)
- april (1)
- arbuscular mycorrhizal fungi (1)
- arctic (1)
- argeted therapy (1)
- arginine (1)
- arlR (1)
- arteriovenous loop (1)
- arthropods (1)
- artifact (1)
- aspergillosis (1)
- association (1)
- astrocytes (1)
- asymmetric dark matter (1)
- atherogenic dyslipidaemia (1)
- atherosclerosis (1)
- atherosclerotic vascular disease (1)
- atrophy Kennedys-disease (1)
- attachment glycoprotein (1)
- attention (1)
- attention capture (1)
- attentional bias (1)
- attentional impulsivity (1)
- audiovisual integration (1)
- audiovisual interactions (1)
- auditory cortex (1)
- auditory stimuli (1)
- aurora kinase A polymorphism (1)
- aurorakinase B (1)
- autism (1)
- autoantigen (1)
- autologous transplantation (1)
- autologous tumor (1)
- autophagy-related (1)
- autosomal-dominant osteopetrosis (1)
- auxin (1)
- axon regeneration (1)
- axonal integrity (1)
- axonal transport (1)
- axons (1)
- azacitidine (1)
- bZIP (1)
- bZIP transcription fators (1)
- bacillus subtilis (1)
- background odor (1)
- bacterial genomes (1)
- bacterial infection (1)
- bacterial pathogens (1)
- banding analyses (1)
- baryon asymmetry (1)
- bcl-2 associated athanogene protein 3 (1)
- bee pollinators (1)
- behavior (1)
- behavioral activation system (1)
- behavioral conditioning (1)
- benzalkonium chloride (1)
- benzimidazole (1)
- beta (1)
- beta-cyclodextrin (1)
- beta-oxidation (1)
- beta-tubulin (1)
- bevacizumab (1)
- bibliometrics (1)
- bibliométrie (1)
- binding protein (1)
- binding proteins (1)
- binge eating (1)
- biochemical characterization (1)
- biodiversity conservation (1)
- biodiversity index (1)
- biodiversity measure (1)
- bioelectrochemistry (1)
- biogenesis (1)
- bioinformatics (1)
- biology (1)
- biomarkers UPA (1)
- biominarlization proteins (1)
- biophosphonate (1)
- biosynthetic gene-cluster (1)
- bipolar disorder (1)
- bipolar disorders (1)
- bird species richness (1)
- birth rates (1)
- blend (1)
- blood plasma (1)
- blood-stream forms (1)
- blood–brain barrier choline transporter (1)
- body fat (1)
- bone (1)
- bone loss (1)
- bone metastasis (1)
- bone-marrow (1)
- bone-mineral density (1)
- bone-targeting radiopharmaceuticals (1)
- bortezomib plus dxamethasone (1)
- borylene (1)
- bradykinin (1)
- brain computer interface (1)
- brain images (1)
- brain potentials (1)
- brain-computer interfaces (1)
- breakpoint (1)
- breast-cancer cells (1)
- bronchial tissue (1)
- brush border membrane (1)
- bryozoan bugula-neritina (1)
- bumblebee nest density (1)
- butterfly euphydryas-aurinia (1)
- c-myc (1)
- caffeic acid bornyl ester (1)
- caffein (1)
- calcium absorption (1)
- calcium imaging (1)
- calcium phosphate (1)
- calcium-phosphate (1)
- cameras (1)
- camponotus aethiops (1)
- campylobacteriosis (1)
- canagliflozin (1)
- cancer cell (1)
- cancer stem cell immunology (1)
- cancer stem cells (1)
- canine and feline cancer therapy (1)
- capacitance (1)
- capsaicin (1)
- carbon metabolism (1)
- carbon nanomaterials (1)
- carcinogen activation (1)
- carcinoma (1)
- cardiac perception (1)
- cardiology (1)
- cardiomyocyte proliferation (1)
- cardiopulmonary exercise testing (1)
- cardiovascular disease (1)
- cardiovascular munster procam (1)
- cardiovascular pharmacology (1)
- cardiovascular risk (1)
- carnivorus plants (1)
- carousel maze (1)
- carriage (1)
- carrier density (1)
- cat (1)
- catechins (1)
- cathepsin (1)
- cathepsin-L (1)
- cations (1)
- cell binding (1)
- cell biology (1)
- cell membrane (1)
- cell membranes (1)
- cell penetrating peptides (1)
- cell-adhesion (1)
- cell-cycle arrest cancer therapy (1)
- cellular internalization (1)
- cellular receptor (1)
- cellular therapy (1)
- cement (1)
- central carbon metabolism (1)
- central core disease (1)
- central metabolism (1)
- centromeric instability (1)
- cerebEND (1)
- cereblon expression (1)
- cerebral arteries (1)
- cerebral artery occlusion (1)
- cerebrovascular diseases (1)
- ceriops decandra (1)
- cetuximab (1)
- chaperone Hfq (1)
- charge-coupled device (1)
- chemical diversity (1)
- chemotherapy resistance (1)
- chi square tests (1)
- chlamydia trachomatis (1)
- chlamydomonas flagella (1)
- cholesterol (1)
- cholesterol depletion (1)
- cholinergic interneurons (1)
- chromatin (1)
- chromatin assembly factors (1)
- chromosomal aberration (1)
- chromosome evolution (1)
- chronic Hepatitis C (1)
- chronic cerebrovascular disease (1)
- chronic heart failure (1)
- chronic kidney-disease (1)
- chronic myelogenous leukemia (1)
- chronic myeloid leukemia (1)
- chronic phase (1)
- chronic thromboembolic pulmonary hypertension (1)
- ciliary neurotrophic factor (1)
- circadian oscillators (1)
- circadian rhythmicity (1)
- circadian rhythms (1)
- circular dichroism (1)
- circular dichroism spectra (1)
- circular-dichroism (1)
- circulation patterns (1)
- class-I (1)
- classical conditioning (1)
- classification (1)
- clausiliidae (1)
- clearance (1)
- cleavage (1)
- climate change (1)
- clinical (1)
- clinical practice guidelines (1)
- clinically isolated syndromes (1)
- cloud (1)
- clumping factor-B (1)
- co-cultivation (1)
- co-evolution (1)
- co-gels (1)
- coagulation (1)
- coatings (1)
- cochlea (1)
- cognitive decline (1)
- cognitive-behavioral therapy (1)
- cognitive-behavioural psychotherapy (1)
- cohesin SMC1-Beta (1)
- cohort studies (1)
- cold stress (1)
- colestilan (1)
- collagens (1)
- colon (1)
- colonies (1)
- colonization (1)
- colony (1)
- colorectal cancer (1)
- columnar architecture (1)
- coma (1)
- comb (1)
- combined immunodeficiency (1)
- combined therapy (1)
- commercial grades (1)
- common genetic determinants (1)
- common variants (1)
- community structures (1)
- comparative molecular field analysis (1)
- comparative molecular similarity index analysis (1)
- complex-III (1)
- complexation (1)
- component (1)
- components (1)
- compound eye (1)
- computer software (1)
- condensed matter physics (1)
- condensed-matter physics (1)
- conditioned response (1)
- conifers (1)
- conjugated mycotoxins (1)
- connective tissue (1)
- conservation (1)
- conservation laws (1)
- consortium (1)
- constraints (1)
- contact-kinin system (1)
- contextual fear (1)
- continous fields (1)
- contrast-enhanced ultrasound (1)
- convergent extension movements (1)
- coping (1)
- copy-number alteration (1)
- coronary artery disease (1)
- coronary heart disease (1)
- corpus cavernosum (1)
- correlated electrons (1)
- correlated systems (1)
- correlates (1)
- cortisol (1)
- cotransporter (1)
- cotton rats (1)
- craving (1)
- crop identification (1)
- crop mapping (1)
- crop monitoring (1)
- crop yield (1)
- crops (1)
- crossover trial (1)
- crystal-structures (1)
- cues (1)
- cultivation (1)
- cultured fibroplasts (1)
- cutaneous patch (1)
- cycle regulation (1)
- cyclic AMP (1)
- cyclic-AMP (1)
- cyclin-dependent kinases (1)
- cycloaddition (1)
- cyclodextrin (1)
- cyclophsophamide (1)
- cysteine protease (1)
- cystic fibrosis (1)
- cytochrome P450 3A4 (1)
- cytogenetic response (1)
- cytokine responses (1)
- cytokinesis (1)
- cytokinin (1)
- cytokinins (1)
- cytolethal distending toxin (1)
- cytosol (1)
- cytotoxicity receptors (1)
- damage (1)
- dark matterWIMP (1)
- dark-matter (1)
- data sharing (1)
- data-bank (1)
- database (1)
- de-novo methylation (1)
- deafness (1)
- decandrinin (1)
- decision making (1)
- declines (1)
- deep bisulfite sequencing (1)
- deep brain-stimulation (1)
- deer cervus-eldi (1)
- defensive reactivity (1)
- deficient mice (1)
- definition (1)
- deformation (1)
- degradation (1)
- delay conditioning (1)
- deletions (1)
- demography (1)
- demyelinating disease (1)
- demyelinating polyradiculoneuropathy (1)
- dendritic cell (1)
- denritic cells (1)
- density (1)
- density-functional theory (1)
- dentichasmias busseolae (1)
- dependent gene-expression (1)
- deprivation (1)
- detection (1)
- determinant (1)
- developing oilseeds (1)
- developmental biology (1)
- developmental plasticity (1)
- developmental reprogramming (1)
- dexamethasone (1)
- diabetes (1)
- diabetes mellitus (1)
- diagnosis (1)
- dialysate (1)
- dialysis (1)
- dialyzer membrane (1)
- diazepam (1)
- dielectric oxides (1)
- different imatinib dose regimens (1)
- differentation (1)
- differential (1)
- differential age distribution (1)
- differentiation (1)
- diffusion (1)
- diffusive component (1)
- digestive system (1)
- dilation (1)
- dionaea muscipula (1)
- dirac fermions (1)
- direct PCR (1)
- directional RNA-Seq (1)
- discrimination (1)
- disease-associated (1)
- disorder (1)
- distal fixation (1)
- distinct (1)
- diversity (1)
- divided attention (1)
- domain (1)
- domains (1)
- dominant optic atrophy (1)
- dopa-induced dyskinesia (1)
- dopamine acetylcholine (1)
- doule blind (1)
- doxorubicin (1)
- drug (1)
- drug delivery vector (1)
- drug discovery (1)
- drug therapy (1)
- drug-addiction (1)
- drug-drug interactions (1)
- dual-task control (1)
- dung beetle coleoptera (1)
- dye stains-all (1)
- dynamic programming (1)
- dynamical mean field theory (1)
- dynamics (1)
- dyspnea (1)
- dystrophic RCS rats (1)
- eExons (1)
- early applied higher imatinib dosages (1)
- early intervention (1)
- early recognition (1)
- early respiratory-failure (1)
- early response (1)
- early-life (1)
- eating behavior (1)
- economic growth (1)
- economy services (1)
- ecosystem services (1)
- ecosystemservices (1)
- edema (1)
- education (1)
- educational attainment (1)
- eigenvector centrality (1)
- ejection fraction (1)
- elderly patients (1)
- elderly persons (1)
- electrically driven (1)
- electrocorticography (1)
- electroencephalogram (1)
- electroencephalography (1)
- electron density (1)
- electronic-structure calculations (1)
- electroporation (1)
- electroweak phase transition (1)
- element (1)
- embryo (1)
- embryonic stem cell (1)
- embryos (1)
- emotion (1)
- emotional information (1)
- emotional pictures (1)
- emotional scene stimuli (1)
- emotional sounds (1)
- empagliflozin (1)
- endocannabinoid release (1)
- endochondral ossification (1)
- endonuclease (1)
- endoplasmatic reticulum (1)
- endothelial cell (1)
- endothelial cells (1)
- endothelial growth factor (1)
- endothelial injury (1)
- endothelial progenitor cells (1)
- endotoxemia (1)
- energies (1)
- energy (1)
- energy bands (1)
- energy signaling (1)
- engaging aantibody (1)
- enhance (1)
- enteric nervous system (1)
- enterobacteria (1)
- enteropathy (1)
- envelope (1)
- environment (1)
- enzyme-linkes immunoassays (1)
- enzymes (1)
- epidemology (1)
- epidural anesthesia (1)
- epidural recording (1)
- epigenetic heterogeneity (1)
- epistemic modality (1)
- erythropoietin (1)
- european birth cohorts (1)
- evaluation (1)
- event related potentials (1)
- event-related FMRI (1)
- evidentiality (1)
- evolutionary mutant model (1)
- exome sequencing (1)
- expenditure (1)
- experience sampling (1)
- experimental autoimmune neuritis (1)
- expertise (1)
- expression site attenuation (1)
- extinction (1)
- extinction risk (1)
- eyes (1)
- face (1)
- facial anomalies (1)
- facial expression (1)
- facial expressions (1)
- facial pain (1)
- factor XI (1)
- factor acetylhydrolase activity (1)
- factor-V-Leiden (1)
- fanconi anemia (1)
- fanconi-anemia (1)
- fatty acids (1)
- fatty liver disease (1)
- fear conditioning (1)
- feasibility (1)
- fenoterol (1)
- fermions (1)
- fetal preconditioning (1)
- fibers (1)
- fibrin D-dimer (1)
- finder using symmetrical best hits (1)
- fish (1)
- fish model (1)
- fission yeast (1)
- flagellar basal body (1)
- flagellum (1)
- flavour symmetry (1)
- floating mass transducer (1)
- flowers (1)
- fluorescence (1)
- fluorescence in-situ hybridization (1)
- fluorescence microscopy (1)
- fluorescence resonance energy transfer (1)
- fluorescent protein (1)
- fluticasone propionate (1)
- flux balance analysis (1)
- focal adhesions (1)
- folinic acid (1)
- follow up (1)
- food addiction (1)
- food carving (1)
- food consumption (1)
- food pictures (1)
- food-gene interactions (1)
- foraging behavior (1)
- force (1)
- forecasting (1)
- forests (1)
- formica cunicularia (1)
- fragmented landscapes (1)
- free energy of solvation (1)
- free space (1)
- free survival (1)
- frequencies (1)
- fruit set (1)
- fruit-quality (1)
- full thickness skin (1)
- fumarate (1)
- functional architecture (1)
- fungal diseases (1)
- fungal pathogens (1)
- fusiform gyrus (1)
- gambling (1)
- gamete (1)
- gamma-cyclodextrin (1)
- gastrointestinal mucositis (1)
- geckos (1)
- gels (1)
- gemcitabine (1)
- gene polymorphism (1)
- gene therapy (1)
- gene-expression (1)
- gene-expression data (1)
- generalization (1)
- generation (1)
- genes and chromosomes (1)
- genetic deletion (1)
- genetic interference (1)
- genetic modifiers (1)
- genetic variability (1)
- genetics (1)
- genome analysis (1)
- genome-wide association (1)
- genomes (1)
- genomic aberrations (1)
- genomic databases (1)
- genomic response (1)
- genomic stability (1)
- geometric mean (1)
- germinative cells (1)
- gesolin function (1)
- gestational age (1)
- glaucoma (1)
- glaucoma surgery (1)
- global change (1)
- global health (1)
- glucocorticoid receptor (1)
- glucose (1)
- glucose tolerance test (1)
- glutamate dehydrogenase (1)
- glutathione (1)
- glycemic control (1)
- glycogen phosphorylase (1)
- glycogen synthase (1)
- glycoproteins (1)
- glycosome (1)
- go/no-go task (1)
- grade 3B (1)
- granulomas (1)
- grasslands (1)
- group B genotype (1)
- group-A (1)
- growth hormone deficiency (1)
- gut bacteria (1)
- gyrase (1)
- habitat destruction (1)
- habitat patch (1)
- habitat preferences (1)
- habitat quality (1)
- habitats (1)
- haemophilus influenzae (1)
- haemoproteus-columbae (1)
- halichondria panicea (1)
- hand/foot malformation (1)
- hands (1)
- haploidentical γδ T lymphocytes (1)
- haplotype (1)
- harmonization (1)
- hashimotos-thyroiditis (1)
- head (1)
- head injury (1)
- health (1)
- healthy children (1)
- hearing impairment (1)
- heart-failure (1)
- heat shock response (1)
- hela cells (1)
- helitron (1)
- helminth infection (1)
- helper T-cells (1)
- hematologic malignancies (1)
- hematopoietic cell transplantation (1)
- hemodialysis (1)
- hemolytic-uremic syndrome (1)
- heptacellular carcinoma (1)
- herbivores (1)
- hernia repair (1)
- heroine (1)
- herpesvirus (1)
- heterodinuclear compound (1)
- heteropathogenicity (1)
- heterotrophic arabidopsis cells (1)
- hexose transporter (1)
- hidden markov-models (1)
- hidden mycotoxins (1)
- hidden-beauty states (1)
- high calorie (1)
- high denisty lipoprotein (1)
- high numbers (1)
- high-bone-mass (1)
- high-dose chemotherapy (1)
- hippocampal neurons (1)
- histology (1)
- hive (1)
- homeodomain transcription factors (1)
- homologous chromosomes (1)
- homologs (1)
- homology search (1)
- honey (1)
- honey bees (1)
- honeybee (1)
- honeycomb lattice (1)
- hormones (1)
- hospitalisation (1)
- host cells (1)
- host-cells (1)
- host-pathogen interactions (1)
- human (1)
- human amygdala (1)
- human brain (1)
- human brian endothelium (1)
- human bruchs membrane (1)
- human cells (1)
- human disease (1)
- human evolution (1)
- human immunodeficiency virus (1)
- human learning (1)
- human liver cells (1)
- human mineralocorticoid receptor (1)
- human movement (1)
- human multiple-myeloma (1)
- human peripheral blood (1)
- human prostate-cancer (1)
- human receptor kinetics (1)
- human serum albumin (1)
- human sodium iodide symporter (hNIS) (1)
- humanized xenograft model (1)
- humidity (1)
- hunger (1)
- hybrid messenger RNA (1)
- hydrogen regulation (1)
- hydrogen-peroxide (1)
- hyperbolic systems (1)
- hyperkalemia (1)
- hyperphosphataemia (1)
- hyperthermophile (1)
- hypogammaglobulinemia (1)
- hypotonic (1)
- hypoxia (1)
- identical twins (1)
- idiopathic inflammatory myopathies (1)
- illness (1)
- illumination (1)
- image correlation spectroscopy (1)
- image properties (1)
- imaging proliferation (1)
- immediate early genes (1)
- immune cell infiltration (1)
- immune escape (1)
- immune modulation (1)
- immune receptors (1)
- immune suppression (1)
- immunoassays (1)
- immunoblotting (1)
- immunocytochemical analysis (1)
- immunodeficiency (1)
- immunosuppression (1)
- immunotherapy (1)
- impact (1)
- implementation (1)
- impulsivity (1)
- in vitro (1)
- in vitro kinase assay (1)
- in vivo (1)
- in vivo cell expansion (1)
- in-vitro models (1)
- in-vivo expression (1)
- incentives (1)
- inconsistencies (1)
- increases atherosclersosis (1)
- incretin secretion (1)
- incus (1)
- independent predictor (1)
- indoleamine 2,3-dioxygenase (1)
- induced impairment (1)
- induced metabolites (1)
- induced obesity (1)
- inducible factor-I (1)
- induction (1)
- infant growth (1)
- infections (1)
- infinite dimensions (1)
- inflammatory response (1)
- influenza (1)
- infusion (1)
- inhalation anesthetics (1)
- inhibitor (1)
- inhibitor PAI-1 (1)
- inhibitory control (1)
- inhibitory receptors (1)
- injecting drug users (1)
- innate immunity (1)
- innate lymphoid cells (1)
- inner ear (1)
- inplane spectral weight (1)
- insects (1)
- insights (1)
- instensively managed farmland (1)
- instruction (1)
- integration (1)
- intellectual disability (1)
- intentional binding (1)
- interaction networks (1)
- interaction surfaces (1)
- interference (1)
- interferon (1)
- interferon alpha (1)
- interleukin-6 (1)
- international cooperation (1)
- interoception (1)
- intervention study (1)
- intestinal microvascular perfusion (1)
- intestinal mucositis (1)
- intranasal corticosteroids (1)
- intraoperative electrocoicography (1)
- invasive candidiasis (1)
- invasive fungal infections (1)
- invertebrate herbivory (1)
- investigators (1)
- iodides (1)
- ionic strength (1)
- ipratropium bromide (1)
- irinotecan (1)
- iron limitation (1)
- iron release (1)
- ischemia (1)
- ischemic brain injury (1)
- ischemic-stroke (1)
- island (1)
- isocaloric intake (1)
- isolation (1)
- isotonic (1)
- journal (1)
- judgement bias (1)
- junction (1)
- kallikrein–kinin system (1)
- karyotype (1)
- karyotype evolution (1)
- katydids orthoptera (1)
- ketogenic diet (1)
- kidney disease; (1)
- kidney function (1)
- kinase Syk (1)
- kinematic analysis (1)
- kinematics (1)
- kinin receptor (1)
- knockout mice (1)
- knowledge of results (1)
- laboratory environment (1)
- lactate dehydrogenase (1)
- lactate threshold (1)
- lactic acid bacteria (1)
- lactobacillus (1)
- laminin receptor (1)
- land cover (1)
- land use (1)
- land-cover (1)
- land-use (1)
- land-use change (1)
- language (1)
- larvae (1)
- larval density (1)
- laser microdissection (1)
- latency (1)
- learning (1)
- learning curve (1)
- left-ventricular function (1)
- leishmaniasis (1)
- length of stay (1)
- lepidoptera (1)
- leptogenesis (1)
- lesions (1)
- lidocaine (1)
- life cycle (1)
- life history (1)
- life stage (1)
- ligand incompatibility (1)
- ligand trail (1)
- limb development (1)
- lineage (1)
- linear regression analysis (1)
- linguistic morphology (1)
- lipid biosynthesis (1)
- lipid rafts (1)
- lipogenesis (1)
- live-attenuated influenza vaccine (1)
- living cells (1)
- living vells (1)
- local enhancement (1)
- localization (1)
- locally advanced disease (1)
- location behavior (1)
- locked-in state (1)
- long terminal repeat (1)
- long-term (1)
- long-term depression (1)
- long-term pain (1)
- longevity (1)
- low birth weight (1)
- lower critical solution temperature (1)
- luciferase (1)
- lung cancer (1)
- lung injury (1)
- lung transplantation (1)
- lung-cancer (1)
- lymph nodes (1)
- lymphoid-tissue (1)
- lymphoid-tissue lymphomas (1)
- mC (1)
- mCherry (1)
- mRNA localization (1)
- mTOR Inhibitor (1)
- machine learning (1)
- macrovascular (1)
- magnetic resonance imaging (1)
- maize kernels (1)
- major depression (1)
- major histocompatibility complex (1)
- malaria (1)
- malaria parasite (1)
- malaria parasites (1)
- malignant hyperthermia (1)
- malignant transformation (1)
- malt lymphoma (1)
- mammalian development (1)
- mammalian septins (1)
- mammalian target of rapamycin (1)
- mantel cell lymphoma (1)
- maps (1)
- marcophages (1)
- marine (1)
- marine bacteria (1)
- marine microalgae (1)
- marine natural product (1)
- marine navigation (1)
- marrow plasma cells (1)
- marrow transplantation (1)
- masked mycotoxins (1)
- masked priming (1)
- mass (1)
- mass spectrometry (1)
- massively multiplayer online role playing games (1)
- maturation (1)
- mean-field theory (1)
- measles virus (1)
- meat (1)
- mechanics (1)
- mechanisms (1)
- medaka (1)
- media geométrica (1)
- medial prefrontal cortex (1)
- medial prefrontal cortex (mPFC) (1)
- medical and biological imaging (1)
- medical research (1)
- medicine (1)
- medida de la biodiversidad (1)
- medium spiny neurons (1)
- meiotic chromosome dynamics (1)
- meiotic chromosomes (1)
- melanoma cell (1)
- melanomas (1)
- melt electrospinning (1)
- membrane characteristics (1)
- membrane organization (1)
- membrane potential (1)
- membrane structures (1)
- membrane-protein topology (1)
- membrans proteins (1)
- memory (1)
- memory consolidation and extinction (1)
- memory errors (1)
- meningococcal disease (1)
- meningococcal lineages (1)
- mesenchymal stem and stromal cells (1)
- messenger-RNA decay (1)
- messenger-RNA translation (1)
- meta-analysis based orthology (1)
- metabolic flux analysis (1)
- metabolic profiling (1)
- metabolic syndrome (1)
- metabolomic changes (1)
- metabolomics (1)
- metanalysis (1)
- metapopulation (1)
- metformin (1)
- miR-126 (1)
- miR-21 (1)
- microcephaly (1)
- microna profiles (1)
- microtubule motor (1)
- microvascular (1)
- microvilli (1)
- middle-ear surgery (1)
- migration (1)
- mir-203 (1)
- mismatch negativity (1)
- missing self (1)
- mitochondria (1)
- mitofilin (1)
- mitotic chromosomes (1)
- mobility (1)
- models (1)
- modified mycotoxins (1)
- modis NDVI (1)
- modulating (1)
- modulators (1)
- mole crickets (1)
- molecular biology (1)
- molecular characterization (1)
- molecular diversity (1)
- molecular imaging (1)
- molecular mass (1)
- molecular structure (1)
- molecular-dynamics simulations (1)
- monetary incentive delay task (1)
- monoallelic expression (1)
- monoclonal gammopathy (1)
- monoclonal-antibodies (1)
- monocytes (1)
- monolayers (1)
- morbid obesity (1)
- morbilliviruses (1)
- morphine (1)
- morphogenesis (1)
- morphogenetic protein (1)
- morphological adaptions (1)
- morphology (1)
- morris water maze (1)
- mortality (1)
- mosquito (1)
- motility disorders (1)
- motoneurons (1)
- mouse model (1)
- mouse models (1)
- multicellular tumor spheroids (1)
- multidrug resistance (1)
- multimodal emotion processing (1)
- multiparameter flow-cytometry (1)
- multiparameter flow-cytpmetry (1)
- multiple myeloma (1)
- multiple system atrophy (1)
- multisensory integration (1)
- multivariate analysis (1)
- multivesicular tubule (1)
- muscular-dystrophy (1)
- mutation (1)
- mycoses (1)
- mycotoxin derivates (1)
- mycotoxin metabolites (1)
- mycotoxins (1)
- myeloperoxidase (1)
- myenteric plexus (1)
- myocardial infarction (1)
- myopathy (1)
- nab-paclitaxel (1)
- nacreous layer formation (1)
- naloxone (1)
- nanodiamond (1)
- nanostructures (1)
- native pollinators (1)
- natively unstructured protein (1)
- natural antisense transcripts (1)
- natural enemies (1)
- natural products (1)
- natural variation (1)
- ncRNA (1)
- neoadjuvant chemotherapy (1)
- neonatal brain (1)
- neophobia (1)
- nerve fibres (1)
- nesbitti (1)
- networks (1)
- neural activity (1)
- neural stem-cell (1)
- neuralgia (1)
- neurite outgrowth inhibitor (1)
- neurobiology (1)
- neuroimaging (1)
- neuron migration (1)
- neuronal differentiation (1)
- neuronal primary culture (1)
- neuronopathy (1)
- neuropathology (1)
- neuroprosthetic devices (1)
- neuroprotection (1)
- neuropsychology (1)
- neuroscience (1)
- neutrino masses (1)
- neutrino mixing (1)
- neutrophil (1)
- next generation sequencing (1)
- nicotinic receptors (1)
- nilotinib (1)
- nitrite respiration (1)
- nitrogen status (1)
- no correlation (1)
- non-Hodgkin's lymphoma (1)
- non-hodgkins-lymphoma (1)
- non-penetrating glaucoma surgery (1)
- non-small cell lung cancer (1)
- non-verbal communication (1)
- noncoding RNAs (1)
- nonhost plant (1)
- novobiocin (1)
- nuclear import (1)
- nuclear-pore complexes (1)
- nucleotide excision-repair (1)
- nutrition (1)
- nutrition education (1)
- nutritional deficiencies (1)
- nympahlidae (1)
- oaks (1)
- obstructive pulmonary disease (1)
- occupancy (1)
- oculomotor dominance (1)
- odor marks (1)
- of-the-literature (1)
- oilseed rape (1)
- oilseeds (1)
- older patients (1)
- olfaction (1)
- olfactory bioassay (1)
- oligonucleotides (1)
- olyelectrolyte domains (1)
- oncogenic transformation (1)
- oncolysis (1)
- oncolytic viral therapy (1)
- oncolytic virus (1)
- optical physics (1)
- optical spectroscopy (1)
- optimization (1)
- oral glucose (1)
- oral mucositis (1)
- orbifrontal cortex (1)
- orbital imaging (1)
- organ dysfunktion (1)
- organ-on-a-chip (1)
- organic molecule (1)
- organic–metal interface (1)
- organotypic (1)
- orthogonal self-assembly (1)
- orthographic representations (1)
- ortholog (1)
- orthology (1)
- orthology network (1)
- oryzias-latipes (1)
- osteoblasts (1)
- osteoclasts (1)
- osteoprogenitor cells (1)
- osteotropism (1)
- output elasticities (1)
- oviedomycin (1)
- oxaliplatin (1)
- oxidative addition (1)
- oxides (1)
- oxygen/glucose deprivation (1)
- p53 expression (1)
- pFADD (1)
- paclitaxel (1)
- pain (1)
- pain sensation (1)
- pancreatic cancer (1)
- parallel evolution (1)
- paralyzed patients (1)
- parasite (1)
- parasitic diseases (1)
- parliamentary interaction (1)
- passive avoidance (1)
- pathogen-associated molecular patterns (1)
- pathogenesis (1)
- pathometabolism (1)
- pathway (1)
- pathways (1)
- patient (1)
- pattern formation (1)
- patterns (1)
- peak oxygen uptake (1)
- peak power (1)
- peginterferon alpha-2B (1)
- penetratin (1)
- penile thrombosis (1)
- people (1)
- peptide (1)
- perceived physical environment (1)
- perception-action (1)
- perception-action coupling (1)
- periodontal diseases (1)
- periodontitis (1)
- peripheral T-cell (1)
- peripheral blood (1)
- peripheral nervous-system (1)
- permeability (1)
- pharmaceutical applications (1)
- pharmacology (1)
- phased metamorphosis (1)
- phenazine (1)
- phenotypic plasticity (1)
- phonology and reading (1)
- phosphatidylinositol-3-kinase (1)
- phosphoantigen (1)
- phosphodiesterase-4 inhibitor (1)
- phospholipase A(2) (1)
- phospholipid fatty acids (1)
- phosphorylase isozymes (1)
- phosphorylation sites (1)
- photodynamic therapy (1)
- photoemission spectroscopy (1)
- photon statistics (1)
- phylogenetics (1)
- phylogeny (1)
- physical activity (1)
- physical properties (1)
- physical sciences (1)
- physics (1)
- phytohormones (1)
- picture processing (1)
- pines (1)
- pixel purity (1)
- pixel size (1)
- place avoidance task (1)
- placebo (1)
- placebo-controlled trial (1)
- plakortide E. (1)
- plakortis halichondroides (1)
- planar cell polarity (1)
- plant community composition (1)
- plant defenses (1)
- plant diversity (1)
- plant hormones (1)
- plant-animal interaction (1)
- plantago lanceolata (1)
- plants response (1)
- plasma D-dimer (1)
- plasma cells (1)
- plasma membrane (1)
- plasma proteins (1)
- plasmid construction (1)
- plasmodium (1)
- platelet activation factor (1)
- platelet receptor (1)
- platinum (1)
- platyfish (1)
- pluripotent stem cells (1)
- pneumona virus (1)
- podoplanin (1)
- polarimetry (1)
- polyadenylation sites (1)
- polycistronic transcription (1)
- polyelectrolyte domains (1)
- polyketide synthase gene (1)
- polymavirus (1)
- polymer (1)
- polymerase chain reaction (1)
- polymerase-chain-reaktion (1)
- polymorphism (1)
- polystyrene (1)
- polyvinyl chloride (1)
- population-based cohort (1)
- populations (1)
- positron-emission-tomography (1)
- post-harvest quality (1)
- post-traumatic stress disorder (1)
- posteroinferior occipitotemporal gyrus (1)
- postherpetic neuralgia (1)
- postoperative care (1)
- posttraumatische Belastungsstörung (1)
- potential marker (1)
- poultry (1)
- predation (1)
- predation risk (1)
- predictive factors (1)
- predictive marker (1)
- predictors (1)
- predicts recovery (1)
- prefrontal cortex (1)
- preschool children (1)
- presynapse (1)
- prevalence (1)
- prevention (1)
- prevention program (1)
- prey growth rate (1)
- priapism (1)
- primary biliary-cirrhosis (1)
- primary breast cancer (1)
- primary cells (1)
- primary human hepatocytes (1)
- primary schoolchildren (1)
- prime visibility (1)
- priming (1)
- proboscis extension response (PER) (1)
- procambarus-clarkii (1)
- products (1)
- profile distances (1)
- progenitors (1)
- prognostic factor (1)
- progressive supranuclear palsy (1)
- prolactin (1)
- promoter region (1)
- promoters (1)
- propionate (1)
- prosthesis (1)
- protease (1)
- protease inhibitor (1)
- protein HFQ (1)
- protein binding (1)
- protein families database (1)
- protein interactions (1)
- protein secondary structure (1)
- protein structure (1)
- protein synthesis (1)
- protein-RNA recognition (1)
- protein-bound solutes (1)
- protein-coupled-receptors (1)
- prototypes (1)
- protozoan parasite (1)
- pseudomonas syringae (1)
- psychiatric-hospitalization (1)
- psychiatry (1)
- psycholinguistics (1)
- psychometric properties (1)
- psychopharmacology (1)
- psychotherapy (1)
- psychotic experiences (1)
- pulmonary absorption (1)
- pulmonary artery (1)
- pulmonary artery pressure (1)
- pulmonary circulation (1)
- pulmonary embolism (1)
- pulmonary function (1)
- pulmonata (1)
- pupae (1)
- pyrazine (1)
- périodiques (1)
- qualité (1)
- quantum communications (1)
- quantum dots (1)
- quantum key distribution (1)
- quantum mechanics (1)
- quantum physics (1)
- quantum-well -wire and -dot devices (1)
- questionnaire assessment (1)
- qutenza (1)
- radar (1)
- radiation (1)
- radiation-induced migration (1)
- radical prostatectomy (1)
- radioiodine therapy (1)
- radiosensibility (1)
- rana temporaria populations (1)
- random forest (1)
- randomized clinical trial (1)
- randomized controlled-trial (1)
- randomized phase-3 trial (1)
- randomized-controlled trial (1)
- ranibizumab (1)
- rat hepatocytes (1)
- rat model (1)
- rat small-intestine (1)
- rating scale (1)
- ray solution scattering (1)
- re-aim framework (1)
- reactivation (1)
- reading disability (1)
- receptive fields (1)
- receptor (1)
- receptor expression (1)
- receptor gene polymorphism (1)
- receptor related protein (1)
- receptor splice variant (1)
- receptor tyrosine kinase (1)
- reciprocal best hit (1)
- recj exonuclease (1)
- recognition (1)
- recombinant proteins (1)
- recommendations (1)
- reconstructed human epidermis (1)
- reconstruction (1)
- recreation-related physical activity (1)
- red blood cells (1)
- red fluorescent protein (1)
- reflection (1)
- reflex (1)
- refractory/relapsed lymphoma (1)
- register (1)
- registration (1)
- regression analysis (1)
- regulation (1)
- regulatory T-cells (1)
- regulatory cells (1)
- regulatory mutations (1)
- regulatory small RNAs (1)
- rehabilitation (1)
- relevance detection (1)
- reliability (1)
- reminiscence (1)
- remodelling (1)
- remote sensing (1)
- remote sequence conservation (1)
- removal (1)
- renal cell carcinoma (1)
- renal disease (1)
- renal system (1)
- reperfusion injury (1)
- replacement (1)
- replication fork (1)
- reporter genes (1)
- reprogramming (1)
- requency (1)
- research funds (1)
- research priorities (1)
- residual cardiovascular risk (1)
- resonators (1)
- resource scheduling (1)
- resource use (1)
- response inhibition (1)
- response regulator (1)
- resting NK cells (1)
- resting-state fMRI (1)
- restrained eaters (1)
- retinal pigment epithelium (1)
- retinotopic organization (1)
- rett (1)
- reward (1)
- reward deficiency syndrome (1)
- rheumatoid arthritis (1)
- rhizophoraceae (1)
- rhodesain (1)
- rhythms (1)
- ribosomal RNA (1)
- riboswitch (1)
- riesgo de extinción (1)
- robust (1)
- rod-to-sphere transition (1)
- roentgenographic assessment (1)
- rofumilast (1)
- roles (1)
- rolling-circle transposons (1)
- roquin (1)
- rumination (1)
- rupture (1)
- ryanodine receptor gene (1)
- s-phase (1)
- sRNA (1)
- saccades (1)
- saccharmyces cerevisiae (1)
- saccharomyes cerevisiae (1)
- safety (1)
- salicylic acid (1)
- salt stress (1)
- sample (1)
- sarcoplasmic reticulum (1)
- satellite (1)
- scFv (1)
- scale (1)
- scanning tunneling microscopy (1)
- scavender receptor (1)
- scoring system (1)
- seasonal influenza (1)
- secondary (1)
- secondary metabolomics (1)
- secondary structure (1)
- sections (1)
- see (1)
- seed (1)
- segmentation (1)
- selection (1)
- selective attention (1)
- semiconductor surfaces (1)
- semiotics (1)
- sense of agency (1)
- sensitivity (1)
- sensorimotor rhythms (1)
- sequence databases (1)
- sequence motif analysis (1)
- sequences (1)
- sequential introduction (1)
- serotonin transporter gene (1)
- serotonin(1A) receptor (1)
- serum (1)
- sevelamer (1)
- severe fibrosis (1)
- severe sepsis (1)
- sevoflurane (1)
- sex (1)
- sex addiction (1)
- sex determination (1)
- sex-determining region (1)
- shannon index (1)
- shelf life (1)
- shiga toxin (1)
- shingles (1)
- shuttle run test (1)
- signal filtering (1)
- signal transduction (1)
- signal-transduction systems (1)
- signaling microdomain (1)
- signaling pathway (1)
- signature (1)
- significance (1)
- significance MGUS (1)
- silicones (1)
- simian foamy viruses (1)
- simpson's index (1)
- single nucleotide polymorphism (1)
- single-nucleotide polymorphisms (1)
- single-stranded-DNA (1)
- single-trial learning (1)
- skeletal metastases (1)
- skeletal muscle (1)
- skeletal myopathy (1)
- skin tumors (1)
- sleep (1)
- slowly-binding reversible inhibitor (1)
- small RNA (1)
- small non-coding RNAs (1)
- small nucleolar RNAs (1)
- small-angle scattering (1)
- smoldering multiple-myeloma (1)
- snow (1)
- snow cover (1)
- snow cover duration (1)
- social actions (1)
- social anxiety (1)
- social communication (1)
- social science research (1)
- socio-demographic (1)
- sodium channels (1)
- sofosbuvir (1)
- soleus muscles (1)
- solubility (1)
- soluble-RNAs (1)
- somatic marker hypothesis (1)
- sound production (1)
- spacer (1)
- spatial attention (1)
- species diversity (1)
- species gastropoda (1)
- species richness (1)
- spectroscopy (1)
- spectrum disorder (1)
- speech (1)
- sperm DNA methylation (1)
- spermatocytes (1)
- sphingomyelinase (1)
- spiders (1)
- spinal cord (1)
- spinal-cord-injury (1)
- spleen (1)
- spliceosomes (1)
- splicing factors (1)
- sponge holicolona-simulans (1)
- sponge-associated actinomyetes (1)
- sports and exercise medicine (1)
- spray (1)
- spread (1)
- squalius alburnoides (1)
- stability (1)
- stable-isotope (1)
- standardized food images (1)
- starch (1)
- statement (1)
- stem cell niche (1)
- stem cells (1)
- stem-cell niche (1)
- stiffness (1)
- stimulated (1)
- stimulation (1)
- stomach (1)
- strawberry (1)
- streptomyces (1)
- striate cortex (1)
- structure prediction (1)
- structure-activity relationship (1)
- study-group ADSR (1)
- subcellular localization (1)
- subfoveal choroidal neovascularization (1)
- subgroup-B (1)
- subretinal space (1)
- substance dependence (1)
- substance use disorder (1)
- substrate specificity (1)
- subunit (1)
- succinylcholine (1)
- sucrose responsiveness (1)
- sucrose sensitivity (1)
- sugar absorption (1)
- sulfonylurea (1)
- supercoiling (1)
- supermolecular carrier systems (1)
- superresolution (1)
- supramolecular chemistry (1)
- surface morphology (1)
- surface proteins (1)
- surface water (1)
- surgery (1)
- surgical and invasive medical procedures (1)
- susceptibility loci (1)
- sustained virological response (1)
- suxamethonium (1)
- symbiotic bacteria (1)
- symptoms (1)
- synapse structure (1)
- synapsis (1)
- synaptic localization (1)
- syndrome (1)
- synthase (1)
- synthetase (1)
- synthetic D-glucose analogy (1)
- systematics (1)
- systemic sclerosis (1)
- systems (1)
- systems biology (1)
- t-CWT (1)
- tandem mass-spectra (1)
- target recognition (1)
- targeted metabolite profiling (1)
- targeting (1)
- taxonomy (1)
- technological constraints (1)
- teeth (1)
- teichoic acids (1)
- telomere attachment (1)
- temporal-lobe epilepsy (1)
- tension (1)
- term fenofibrate therapy (1)
- term-follow-up (1)
- tertiary lymphoid structures (1)
- testis (1)
- tettigoniidae (1)
- thalidomide maintenance (1)
- therapeutic options (1)
- thermoregulation (1)
- thoracic diaphragm (1)
- three-dimensional microscopy (1)
- three-dimensional quantitative structure–activity relationship (1)
- thrombin (1)
- thrombosis (1)
- time series analysis (1)
- time to exhaustion (1)
- time-resolved spectroscopy (1)
- tissue (1)
- tissue engineering (1)
- tissue morphogenesis (1)
- tissue-specific enhancers (1)
- tolerance (1)
- tool (1)
- topography (1)
- torsional energy (1)
- total HIP-arthroplasty (1)
- tousled-like kinases (1)
- toxin (1)
- toxins (1)
- trabecular bone (1)
- trace conditioning (1)
- traction (1)
- trail-mediated apoptosis (1)
- transcranial magnetic stimulation (1)
- transcranial magnetic stimulation (TMS) (1)
- transcription factor FOXP1 (1)
- transcription factor MIZ-1 (1)
- transcriptional start site (1)
- transcriptional uni (1)
- transcripts (1)
- transfection (1)
- transfer RNA-synthetases (1)
- transformation (1)
- transgenic mice (1)
- transient global ischemia (1)
- transient receptor potential vanilloid 1 (TRPV1) (1)
- transition metal oxides (1)
- transition metals (1)
- transition state (1)
- translation (1)
- translesion synthesis (1)
- translocation (1)
- transmission electron microscopy (1)
- transmission model (1)
- transport (1)
- transport inhibition assay (1)
- transport systems (1)
- transport-related physical activity (1)
- transposition (1)
- treatment options (1)
- tree plantations (1)
- trees (1)
- trigeminal nerve (1)
- trigeminal neuropathy (1)
- triglyceride accumulation (1)
- triglyceride-rich lipoproteins (1)
- trimethyl-β-cyclodextrin (1)
- tropical dry forest conservation (1)
- tropical forest (1)
- trypanosoma brucei (1)
- tumor dormancy (1)
- tumor immune escape (1)
- tumor immunology (1)
- tumor immunosurveillance (1)
- tumor stem cells (1)
- tumor suppressor genes (1)
- tumor tissue (1)
- tumor-propagating cells (1)
- tumors (1)
- tundra (1)
- type-1 diabetes mellitus (1)
- type-2 diabetes mellitus (1)
- tyrosine-protein kinase (1)
- ubiquitin (1)
- ultra-high risk (1)
- ultrafast measurements (1)
- ultrafast spectroscopy (1)
- unconscious processing (1)
- under five children (1)
- undetermined significance MGUS (1)
- ungegenständliche Erfahrungen (1)
- universality (1)
- unstructured proteins (1)
- urban-rural gradient (1)
- uremic toxin (1)
- urinary-tract-infection (1)
- uropathogenic Escherichia coli (1)
- utilization (1)
- vaccination (1)
- vaccine (1)
- vaccine development (1)
- vaccinia virus (1)
- validity (1)
- variant detection (1)
- variant surface glycoprotein (1)
- variant surface glycoprotein (VSG) (1)
- variants (1)
- vascular access (1)
- vector cloning (1)
- vegetation phenology (1)
- vegetative state (1)
- velocity (1)
- venous thromboembolic disease (1)
- venous thrombosis (1)
- ventral stream (1)
- vesicles (1)
- vibration (1)
- vibrio parahaemolyticus (1)
- video gaming masked stimuli (1)
- video-game (1)
- vigilance decrement (1)
- viral clearance (1)
- viral entry (1)
- viral microRNAs (1)
- viral replication (1)
- viral transmission and infection (1)
- virtual reality (1)
- virtual screening (1)
- virulence genes (1)
- virus infection (1)
- virus-infected cells (1)
- visceral fat (1)
- visual cues (1)
- visual learning (1)
- visual perception (1)
- visual resolution deficit (1)
- visual stimuli (1)
- visual-attention (1)
- visuo-motor coordination abilities (1)
- vitro contracture test (1)
- vocabulary (1)
- volatile anesthetics (1)
- volatiles (1)
- waggle dance (1)
- walking (1)
- wavelet (1)
- weight-gain (1)
- well-being (1)
- wheeze (1)
- wheezing (1)
- wild (1)
- wild bees (1)
- wild-type (1)
- word form area (1)
- work economy (1)
- world of warcraft (1)
- xanthurenic acid (1)
- xeroderma-pigmentosum (1)
- xiphophorus maculatus (1)
- zebrafish (1)
- évaluation (1)
- índice de biodiversidad (1)
- γ-glutamyl cycle (1)
- γδ T cells (1)
Institute
- Theodor-Boveri-Institut für Biowissenschaften (75)
- Institut für Psychologie (26)
- Medizinische Klinik und Poliklinik II (25)
- Institut für Molekulare Infektionsbiologie (23)
- Neurologische Klinik und Poliklinik (23)
- Pathologisches Institut (21)
- Medizinische Klinik und Poliklinik I (20)
- Physikalisches Institut (18)
- Klinik und Poliklinik für Psychiatrie, Psychosomatik und Psychotherapie (17)
- Julius-von-Sachs-Institut für Biowissenschaften (16)
Sonstige beteiligte Institutionen
- Clinical Trial Center (CTC) / Zentrale für Klinische Studien Würzburg (ZKSW) (3)
- Röntgen Center for Complex Material Systems (RCCM), Am Hubland, 97074 W¨urzburg, Germany (2)
- Wilhelm-Conrad-Röntgen-Forschungszentrum für komplexe Materialsysteme (2)
- Comprehensive Hearing Center, Department of ORL, Plastic, Aesthetic and Reconstructive Head and Neck Surgery, Würzburg, Germany (1)
- DNA Analytics Core Facility, Biocenter, University of Würzburg, Würzburg, Germany (1)
- Department of Animal Ecology and Tropical Biology, University of Würzburg, Würzburg, Germany (1)
- Department of Paediatric Radiology, Institute of Diagnostic and Interventional Radiology, Josef-Schneider-Straße 2, Wuerzburg 97080, Germany (1)
- Forschungsstation Fabrikschleichach (1)
- Interdisziplinäres Zentrum für Klinische Forschung (ZIKF), Würzburg (1)
- Molecular Nutrition Research, Interdisciplinary Research Center, Justus-Liebig-University of Giessen (1)
The composition of stable-isotope labelled isotopologues/isotopomers in metabolic products can be measured by mass spectrometry and supports the analysis of pathways and fluxes. As a prerequisite, the original mass spectra have to be processed, managed and stored to rapidly calculate, analyse and compare isotopomer enrichments to study, for instance, bacterial metabolism in infection. For such applications, we provide here the database application ‘Isotopo’. This software package includes (i) a database to store and process isotopomer data, (ii) a parser to upload and translate different data formats for such data and (iii) an improved application to process and convert signal intensities from mass spectra of \(^{13}C\)-labelled metabolites such as tertbutyldimethylsilyl-derivatives of amino acids. Relative mass intensities and isotopomer distributions are calculated applying a partial least square method with iterative refinement for high precision data. The data output includes formats such as graphs for overall enrichments in amino acids. The package is user-friendly for easy and robust data management of multiple experiments.
A novel magnetic ground state is reported for the Hubbard Hamiltonian in strained graphene. When the chemical potential lies close to the Dirac point, the ground state exhibits locally both the Neel and ferromagnetic orders, even for weak Hubbard interaction. Whereas the Neel order parameter remains of the same sign in the entire system, the magnetization at the boundary takes the opposite sign from the bulk. The total magnetization vanishes this way, and the magnetic ground state is globally only an antiferromagnet. This peculiar ordering stems from the nature of the strain-induced single-particle zero-energy states, which have support on one sublattice of the honeycomb lattice in the bulk, and on the other sublattice near the boundary of a finite system. We support our claim with the self-consistent numerical calculation of the order parameters, as well as by the Monte Carlo simulations of the Hubbard model in both uniformly and nonuniformly strained honeycomb lattice. The present result is contrasted with the magnetic ground state of the same Hubbard model in the presence of a true magnetic field (and for vanishing Zeeman coupling), which is exclusively Neel ordered, with zero local magnetization everywhere in the system.
Mutations in the oncogenic PIK3CA gene are found in 10-20% of colorectal cancers (CRCs) and are associated with poor prognosis. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and agonistic TRAIL death receptor antibodies emerged as promising anti-neoplastic therapeutics, but to date failed to prove their capability in the clinical setting as especially primary tumors exhibit high rates of TRAIL resistance. In our study, we investigated the molecular mechanisms underlying TRAIL resistance in CRC cells with a mutant PIK3CA (PIK3CA-mut) gene. We show that inhibition of the constitutively active phosphatidylinositol-3 kinase (PI3K)/Akt signaling pathway only partially overcame TRAIL resistance in PIK3CA-mut-protected HCT116 cells, although synergistic effects of TRAIL plus PI3K, Akt or cyclin-dependent kinase (CDK) inhibitors could be noted. In sharp contrast, TRAIL triggered full-blown cell death induction in HCT116 PIK3CA-mut cells treated with proteasome inhibitors such as bortezomib and MG132. At the molecular level, resistance of HCT116 PIK3CA-mut cells against TRAIL was reflected by impaired caspase-3 activation and we provide evidence for a crucial involvement of the E3-ligase X-linked inhibitor of apoptosis protein (XIAP) therein. Drugs interfering with the activity and/or the expression of XIAP, such as the second mitochondria-derived activator of caspase mimetic BV6 and mithramycin-A, completely restored TRAIL sensitivity in PIK3CA-mut-protected HCT116 cells independent of a functional mitochondrial cell death pathway. Importantly, proteasome inhibitors and XIAP-targeting agents also sensitized other CRC cell lines with mutated PIK3CA for TRAIL-induced cell death. Together, our data suggest that proteasome-or XIAP-targeting drugs offer a novel therapeutic approach to overcome TRAIL resistance in PIK3CA-mutated CRC.
Words are built from smaller meaning bearing parts, called morphemes. As one word can contain multiple morphemes, one morpheme can be present in different words. The number of distinct words a morpheme can be found in is its family size. Here we used Birth-Death-Innovation Models (BDIMs) to analyze the distribution of morpheme family sizes in English and German vocabulary over the last 200 years. Rather than just fitting to a probability distribution, these mechanistic models allow for the direct interpretation of identified parameters. Despite the complexity of language change, we indeed found that a specific variant of this pure stochastic model, the second order linear balanced BDIM, significantly fitted the observed distributions. In this model, birth and death rates are increased for smaller morpheme families. This finding indicates an influence of morpheme family sizes on vocabulary changes. This could be an effect of word formation, perception or both. On a more general level, we give an example on how mechanistic models can enable the identification of statistical trends in language change usually hidden by cultural influences.
Objective: The aim of this longitudinal study was to identify predictors of instantaneous well-being in patients with amyotrophic lateral sclerosis (ALS). Based on flow theory well-being was expected to be highest when perceived demands and perceived control were in balance, and that thinking about the past would be a risk factor for rumination which would in turn reduce well-being.
Methods: Using the experience sampling method, data on current activities, associated aspects of perceived demands, control, and well-being were collected from 10 patients with ALS three times a day for two weeks.
Results: Results show that perceived control was uniformly and positively associated with well-being, but that demands were only positively associated with well-being when they were perceived as controllable. Mediation analysis confirmed thinking about the past, but not thinking about the future, to be a risk factor for rumination and reduced well-being.
Discussion: Findings extend our knowledge of factors contributing to well-being in ALS as not only perceived control but also perceived demands can contribute to well-being. They further show that a focus on present experiences might contribute to increased well-being.
Despite improved survival in the Rituximab (R) era, a considerable number of patients with diffuse large B-cell lymphoma (DLBCL) ultimately die from the disease. Functional imaging using [18F]fluorodeoxyglucose-PET is suggested for assessment of residual viable tumor very early during treatment but is compromised by non-specific tracer retention in inflammatory lesions. The PET tracer [18F]fluorodeoxythymidine (FLT) as surrogate marker of tumor proliferation may overcome this limitation. We present results of a prospective clinical study testing FLT-PET as superior and early predictor of response to chemotherapy and outcome in DLBCL. 54 patients underwent FLT-PET prior to and one week after the start of R-CHOP chemotherapy. Repetitive FLT-PET imaging was readily implemented into the diagnostic work-up. Our data demonstrate that the reduction of FLT standard uptake valuemean (SUVmean) and SUVmax one week after chemotherapy was significantly higher in patients achieving complete response (CR, n=48; non-CR, n=6; p<0.006). Martingale-residual and Cox proportional hazard analyses showed a significant monotonous decrease of mortality risk with increasing change in SUV. Consistent with these results, early FLT-PET response showed relevant discriminative ability in predicting CR. In conclusion, very early FLT-PET in the course of R-CHOP chemotherapy is feasible and enables identification of patients at risk for treatment failure.
Background and Purpose
In animal models, von Willebrand factor (VWF) is involved in thrombus formation and propagation of ischemic stroke. However, the pathophysiological relevance of this molecule in humans, and its potential use as a biomarker for the risk and severity of ischemic stroke remains unclear. This study had two aims: to identify predictors of altered VWF levels and to examine whether VWF levels differ between acute cerebrovascular events and chronic cerebrovascular disease (CCD).
Methods
A case–control study was undertaken between 2010 and 2013 at our University clinic. In total, 116 patients with acute ischemic stroke (AIS) or transitory ischemic attack (TIA), 117 patients with CCD, and 104 healthy volunteers (HV) were included. Blood was taken at days 0, 1, and 3 in patients with AIS or TIA, and once in CCD patients and HV. VWF serum levels were measured and correlated with demographic and clinical parameters by multivariate linear regression and ANOVA.
Results
Patients with CCD (158±46%) had significantly higher VWF levels than HV (113±36%, P<0.001), but lower levels than AIS/TIA patients (200±95%, P<0.001). Age, sex, and stroke severity influenced VWF levels (P<0.05).
Conclusions
VWF levels differed across disease subtypes and patient characteristics. Our study confirms increased VWF levels as a risk factor for cerebrovascular disease and, moreover, suggests that it may represent a potential biomarker for stroke severity, warranting further investigation.
Background: Different parameters have been determined for prediction of treatment outcome in hepatitis c virus genotype 1 infected patients undergoing pegylated interferon, ribavirin combination therapy. Results on the importance of vitamin D levels are conflicting. In the present study, a comprehensive analysis of vitamin D levels before and during therapy together with single nucleotide polymorphisms involved in vitamin D metabolism in the context of other known treatment predictors has been performed.
Methods: In a well characterized prospective cohort of 398 genotype 1 infected patients treated with pegylated interferon-alpha and ribavirin for 24-72 weeks (INDIV-2 study) 25-OH-vitamin D levels and different single nucleotide polymorphisms were analyzed together with known biochemical parameters for a correlation with virologic treatment outcome.
Results: Fluctuations of more than 5 (10) ng/ml in 25-OH-vitamin D-levels have been observed in 66 (39) % of patients during the course of antiviral therapy and neither pretreatment nor under treatment 25-OH-vitamin D-levels were associated with treatment outcome. The DHCR7-TT-polymorphism within the 7-dehydrocholesterol-reductase showed a significant association (P = 0.031) to sustained viral response in univariate analysis. Among numerous further parameters analyzed we found that age (OR = 1.028, CI = 1.002-1.056, P = 0.035), cholesterol (OR = 0.983, CI = 0.975-0.991, P<0.001), ferritin (OR = 1.002, CI = 1.000-1.004, P = 0.033), gGT (OR = 1.467, CI = 1.073-2.006, P = 0.016) and IL28B-genotype (OR = 2.442, CI = 1.271-4.695, P = 0.007) constituted the strongest predictors of treatment response.
Conclusions: While 25-OH-vitamin D-levels levels show considerable variations during the long-lasting course of antiviral therapy they do not show any significant association to treatment outcome in genotype 1 infected patients.
Modulation of sensorimotor rhythms (SMR) was suggested as a control signal for brain-computer interfaces (BCI). Yet, there is a population of users estimated between 10 to 50% not able to achieve reliable control and only about 20% of users achieve high (80–100%) performance. Predicting performance prior to BCI use would facilitate selection of the most feasible system for an individual, thus constitute a practical benefit for the user, and increase our knowledge about the correlates of BCI control. In a recent study, we predicted SMR-BCI performance from psychological variables that were assessed prior to the BCI sessions and BCI control was supported with machine-learning techniques. We described two significant psychological predictors, namely the visuo-motor coordination ability and the ability to concentrate on the task. The purpose of the current study was to replicate these results thereby validating these predictors within a neurofeedback based SMR-BCI that involved no machine learning.Thirty-three healthy BCI novices participated in a calibration session and three further neurofeedback training sessions. Two variables were related with mean SMR-BCI performance: (1) a measure for the accuracy of fine motor skills, i.e., a trade for a person’s visuo-motor control ability; and (2) subject’s “attentional impulsivity”. In a linear regression they accounted for almost 20% in variance of SMR-BCI performance, but predictor (1) failed significance. Nevertheless, on the basis of our prior regression model for sensorimotor control ability we could predict current SMR-BCI performance with an average prediction error of M = 12.07%. In more than 50% of the participants, the prediction error was smaller than 10%. Hence, psychological variables played a moderate role in predicting SMR-BCI performance in a neurofeedback approach that involved no machine learning. Future studies are needed to further consolidate (or reject) the present predictors.
Background: Myofibrillar myopathies (MFM) are a group of phenotypically and genetically heterogeneous neuromuscular disorders, which are characterized by protein aggregations in muscle fibres and can be associated with multisystemic involvement.
Methods: We screened a large cohort of 38 index patients with MFM for mutations in the nine thus far known causative genes using Sanger and next generation sequencing (NGS). We studied the clinical and histopathological characteristics in 38 index patients and five additional relatives (n = 43) and particularly focused on the associated multisystemic symptoms.
Results: We identified 14 heterozygous mutations (diagnostic yield of 37%), among them the novel p. Pro209Gln mutation in the BAG3 gene, which was associated with onset in adulthood, a mild phenotype and an axonal sensorimotor polyneuropathy, in the absence of giant axons at the nerve biopsy. We revealed several novel clinical phenotypes and unusual multisystemic presentations with previously described mutations: hearing impairment with a FLNC mutation, dysphonia with a mutation in DES and the first patient with a FLNC mutation presenting respiratory insufficiency as the initial symptom. Moreover, we described for the first time respiratory insufficiency occurring in a patient with the p. Gly154Ser mutation in CRYAB. Interestingly, we detected a polyneuropathy in 28% of the MFM patients, including a BAG3 and a MYOT case, and hearing impairment in 13%, including one patient with a FLNC mutation and two with mutations in the DES gene. In four index patients with a mutation in one of the MFM genes, typical histological findings were only identified at the ultrastructural level (29%).
Conclusions: We conclude that extraskeletal symptoms frequently occur in MFM, particularly cardiac and respiratory involvement, polyneuropathy and/or deafness. BAG3 mutations should be considered even in cases with a mild phenotype or an adult onset. We identified a genetic defect in one of the known genes in less than half of the MFM patients, indicating that more causative genes are still to be found. Next generation sequencing techniques should be helpful in achieving this aim.
The rapid appearance of resistant malarial parasites after introduction of atovaquone (ATQ) drug has prompted the search for new drugs as even single point mutations in the active site of Cytochrome b protein can rapidly render ATQ ineffective. The presence of Y268 mutations in the Cytochrome b (Cyt b) protein is previously suggested to be responsible for the ATQ resistance in Plasmodium falciparum (P. falciparum). In this study, we examined the resistance mechanism against ATQ in P. falciparum through computational methods. Here, we reported a reliable protein model of Cyt bc1 complex containing Cyt b and the Iron-Sulphur Protein (ISP) of P. falciparum using composite modeling method by combining threading, ab initio modeling and atomic-level structure refinement approaches. The molecular dynamics simulations suggest that Y268S mutation causes ATQ resistance by reducing hydrophobic interactions between Cyt bc1 protein complex and ATQ. Moreover, the important histidine contact of ATQ with the ISP chain is also lost due to Y268S mutation. We noticed the induced mutation alters the arrangement of active site residues in a fashion that enforces ATQ to find its new stable binding site far away from the wild-type binding pocket. The MM-PBSA calculations also shows that the binding affinity of ATQ with Cyt bc1 complex is enough to hold it at this new site that ultimately leads to the ATQ resistance.
The paracaspase Malt1 is a central regulator of antigen receptor signaling that is frequently mutated in human lymphoma. As a scaffold, it assembles protein complexes for NF-kappa B activation, and its proteolytic domain cleaves negative NF-kappa B regulators for signal enforcement. Still, the physiological functions of Malt1-protease are unknown. We demonstrate that targeted Malt1-paracaspase inactivation induces a lethal inflammatory syndrome with lymphocyte-dependent neurodegeneration in vivo. Paracaspase activity is essential for regulatory T cell (Treg) and innate-like B cell development, but it is largely dispensable for overcoming Malt1-dependent thresholds for lymphocyte activation. In addition to NF-kappa B inhibitors, Malt1 cleaves an entire set of mRNA stability regulators, including Roquin-1, Roquin-2, and Regnase-1, and paracaspase inactivation results in excessive interferon gamma (IFN gamma) production by effector lymphocytes that drive pathology. Together, our results reveal distinct threshold and modulatory functions of Malt1 that differentially control lymphocyte differentiation and activation pathways and demonstrate that selective paracaspase blockage skews systemic immunity toward destructive autoinflammation.
Background and purpose - Due to the relative lack of reports on the medium- to long-term clinical and radiographic results of modular femoral cementless revision, we conducted this study to evaluate the medium- to long-term results of uncemented femoral stem revisions using the modular MRP-TITAN stem with distal diaphyseal fixation in a consecutive patient series.
Patients and methods - We retrospectively analyzed 163 femoral stem revisions performed between 1993 and 2001 with a mean follow-up of 10 (5-16) years. Clinical assessment included the Harris hip score (HHS) with reference to comorbidities and femoral defect sizes classified by Charnley and Paprosky. Intraoperative and postoperative complications were analyzed and the failure rate of the MRP stem for any reason was examined.
Results - Mean HHS improved up to the last follow-up (37 (SD 24) vs. 79 (SD 19); p < 0.001). 99 cases (61%) had extensive bone defects (Paprosky IIB-III). Radiographic evaluation showed stable stem anchorage in 151 cases (93%) at the last follow-up. 10 implants (6%) failed for various reasons. Neither a breakage of a stem nor loosening of the morse taper junction was recorded. Kaplan-Meier survival analysis revealed a 10-year survival probability of 97% (95% CI: 95-100).
Interpretation - This is one of the largest medium- to longterm analyses of cementless modular revision stems with distal diaphyseal anchorage. The modular MRP-TITAN was reliable, with a Kaplan-Meier survival probability of 97% at 10 years.
Two-dimensional electron gases (2DEGs) at transition-metal oxide (TMO) interfaces, and boundary states in topological insulators, are being intensively investigated. The former system harbors superconductivity, large magneto-resistance, and ferromagnetism. In the latter, honeycomb-lattice geometry plus bulk spin-orbit interactions lead to topologically protected spin-polarized bands. 2DEGs in TMOs with a honeycomb-like structure could yield new states of matter, but they had not been experimentally realized, yet. We successfully created a 2DEG at the (111) surface of KTaO3, a strong insulator with large spin-orbit coupling. Its confined states form a network of weakly-dispersing electronic gutters with 6-fold symmetry, a topology novel to all known oxide-based 2DEGs. If those pertain to just one Ta-(111) bilayer, model calculations predict that it can be a topological metal. Our findings demonstrate that completely new electronic states, with symmetries not realized in the bulk, can be tailored in oxide surfaces, promising for TMO-based devices.
Obligate intracellular bacteria depend entirely on nutrients from the host cell for their reproduction. Here, we show that obligate intracellular Chlamydia downregulate the central tumor suppressor p53 in human cells. This reduction of p53 levels is mediated by the PI3K-Akt signaling pathway, activation of HDM2, and subsequent proteasomal degradation of p53. The stabilization of p53 in human cells severely impaired chlamydial development and caused the loss of infectious particle formation. DNA-damage-induced p53 interfered with chlamydial development through downregulation of the pentose phosphate pathway (PPP). Increased expression of the PPP key enzyme glucose-6-phosphate dehydrogenase rescued the inhibition of chlamydial growth induced by DNA damage or stabilized p53. Thus, downregulation of p53 is a key event in the chlamydial life cycle that reprograms the host cell to create a metabolic environment supportive of chlamydial growth.
Background: Patients presenting with bilateral trigeminal hypoesthesia may go on to have trigeminal isolated sensory neuropathy, a benign, purely trigeminal neuropathy, or facial-onset sensory motor neuronopathy (FOSMN), a malignant life-threatening condition. No diagnostic criteria can yet differentiate the two conditions at their onset. Nor is it clear whether the two diseases are distinct entities or share common pathophysiological mechanisms.
Methods: Seeking pathophysiological and diagnostic information to distinguish these two conditions at their onset, in this neurophysiological and morphometric study we neurophysiologically assessed function in myelinated and unmyelinated fibres and histologically examined supraorbital nerve biopsy specimens with optic and electron microscopy in 13 consecutive patients with recent onset trigeminal hypoesthesia and pain.
Results: The disease course distinctly differed in the 13 patients. During a mean 10 year follow-up whereas in eight patients the disease remained relatively stable, in the other five it progressed to possibly life-threatening motor disturbances and extra-trigeminal spread. From two to six years elapsed between the first sensory symptoms and the onset of motor disorders. In patients with trigeminal isolated sensory neuropathy (TISN) and in those with FOSMN neurophysiological and histological examination documented a neuronopathy manifesting with trigeminal nerve damage selectively affecting myelinated fibres, but sparing the Ia-fibre-mediated proprioceptive reflex.
Conclusions: Although no clinical diagnostic criteria can distinguish the two conditions at onset, neurophysiological and nerve-biopsy findings specify that in both disorders trigeminal nerve damage manifests as a dissociated neuronopathy affecting myelinated and sparing unmyelinated fibres, thus suggesting similar pathophysiological mechanisms.
Evidence based clinical guidelines are implemented to treat patients efficiently that include efficacy, tolerability but also health economic considerations. This is of particular relevance to the new direct acting antiviral agents that have revolutionized treatment of chronic hepatitis C. For hepatitis C genotypes 2/3 interferon free treatment is already available with sofosbuvir plus ribavirin. However, treatment with sofosbuvir-based regimens is 10-20 times more expensive compared to pegylated interferon alfa and ribavirin (PegIFN/RBV). It has to be discussed if PegIFN/RBV is still an option for easy to treat patients. We assessed the treatment of patients with chronic hepatitis C genotypes 2/3 with PegIFN/RBV in a real world setting according to the latest German guidelines. Overall, 1006 patients were recruited into a prospective patient registry with 959 having started treatment. The intention-to-treat analysis showed poor SVR (GT2 61%, GT3 47%) while patients with adherence had excellent SVR in the per protocol analysis (GT2 96%, GT3 90%). According to guidelines, 283 patients were candidates for shorter treatment duration, namely a treatment of 16 weeks (baseline HCV-RNA <800.000 IU/mL, no cirrhosis and RVR). However, 65% of these easy to treat patients have been treated longer than recommended that resulted in higher costs but not higher SVR rates. In conclusion, treatment with PegIFN/RBV in a real world setting can be highly effective yet similar effective than PegIFN +/- sofosbuvir/RBV in well-selected naive G2/3 patients. Full adherence to guidelines could be further improved, because it would be important in the new era with DAA, especially to safe resources.
Invasive fungal infections are a main cause of morbidity and mortality in cancer patients undergoing intensive chemotherapy regimens. Early antifungal treatment is mandatory to improve survival. Today, a number of effective and better-tolerated but more expensive antifungal agents compared to the former gold standard amphotericin B deoxycholate are available. Clinical decision-making must consider results from numerous studies and published guidelines, as well as licensing status and cost pressure. New developments in antifungal prophylaxis improving survival rates result in a continuous need for actualization. The treatment options for invasive Candida infections include fluconazole, voriconazole, and amphotericin B and its lipid formulations, as well as echinocandins. Voriconazole, amphotericin B, amphotericin B lipid formulations, caspofungin, itraconazole, and posaconazole are available for the treatment of invasive aspergillosis. Additional procedures, such as surgical interventions, immunoregulatory therapy, and granulocyte transfusions, have to be considered. The Infectious Diseases Working Party of the German Society of Hematology and Oncology here presents its 2008 recommendations discussing the dos and do-nots, as well as the problems and possible solutions, of evidence criteria selection.
The aim of this work was to conduct a comprehensive study about the transport properties of NSAIDs across the blood-brain barrier (BBB) in vitro. Transport studies with celecoxib, diclofenac, ibuprofen, meloxicam, piroxicam and tenoxicam were accomplished across Transwell models based on cell line PBMEC/C1-2, ECV304 or primary rat brain endothelial cells. Single as well as group substance studies were carried out. In group studies substance group compositions, transport medium and serum content were varied, transport inhibitors verapamil and probenecid were added. Resulted permeability coefficients were compared and normalized to internal standards diazepam and carboxyfluorescein. Transport rankings of NSAIDs across each model were obtained. Single substance studies showed similar rankings as corresponding group studies across PBMEC/C1-2 or ECV304 cell layers. Serum content, glioma conditioned medium and inhibitors probenecid and verapamil influenced resulted permeability significantly. Basic differences of transport properties of the investigated NSAIDs were similar comparing all three in vitro BBB models. Different substance combinations in the group studies and addition of probenecid and verapamil suggested that transporter proteins are involved in the transport of every tested NSAID. Results especially underlined the importance of same experimental conditions (transport medium, serum content, species origin, cell line) for proper data comparison.
Despite the obvious clinical significance of post-stroke angiogenesis in aged subjects, a detailed transcriptomic analysis of post-stroke angiogenesis has not yet been undertaken in an aged experimental model. In this study, by combining stroke transcriptomics with immunohistochemistry in aged rats and post-stroke patients, we sought to identify an age-specific gene expression pattern that may characterize the angiogenic process after stroke. We found that both young and old infarcted rats initiated vigorous angiogenesis. However, the young rats had a higher vascular density by day 14 post-stroke. “New-for-stroke” genes that were linked to the increased vasculature density in young animals included Angpt2, Angptl2, Angptl4, Cib1, Ccr2, Col4a2, Cxcl1, Lef1, Hhex, Lamc1, Nid2, Pcam1, Plod2, Runx3, Scpep1, S100a4, Tgfbi, and Wnt4, which are required for sprouting angiogenesis, reconstruction of the basal lamina (BL), and the resolution phase. The vast majority of genes involved in sprouting angiogenesis (Angpt2, Angptl4, Cib1, Col8a1, Nrp1, Pcam1, Pttg1ip, Rac2, Runx1, Tnp4, Wnt4); reconstruction of a new BL (Col4a2, Lamc1, Plod2); or tube formation and maturation (Angpt1, Gpc3, Igfbp7, Sparc, Tie2, Tnfsf10), had however, a delayed upregulation in the aged rats. The angiogenic response in aged rats was further diminished by the persistent upregulation of “inflammatory” genes (Cxcl12, Mmp8, Mmp12, Mmp14, Mpeg1, Tnfrsf1a, Tnfrsf1b) and vigorous expression of genes required for the buildup of the fibrotic scar (Cthrc1, Il6ra, Il13ar1, Il18, Mmp2, Rassf4, Tgfb1, Tgfbr2, Timp1). Beyond this barrier, angiogenesis in the aged brains was similar to that in young brains. We also found that the aged human brain is capable of mounting a vigorous angiogenic response after stroke, which most likely reflects the remaining brain plasticity of the aged brain.