Refine
Year of publication
- 2014 (903) (remove)
Document Type
- Journal article (446)
- Doctoral Thesis (365)
- Complete part of issue (49)
- Review (9)
- Working Paper (8)
- Study Thesis (term paper) (7)
- Book article / Book chapter (5)
- Conference Proceeding (3)
- Preprint (3)
- Book (2)
Keywords
- Würzburg (48)
- University (47)
- Universität (47)
- Wuerzburg (47)
- Wurzburg (47)
- gene expression (12)
- Maus (11)
- T-Lymphozyt (10)
- expression (10)
- Rezension (8)
- apoptosis (7)
- cancer (7)
- metabolism (7)
- phosphorylation (7)
- Apoptosis (6)
- Genexpression (6)
- Thrombozyt (6)
- Transkriptionsfaktor (6)
- escherichia coli (6)
- flow cytometry (6)
- lymphoma (6)
- Archäologie (5)
- antibodies (5)
- cytokines (5)
- cytoskeleton (5)
- dendritic cells (5)
- disease (5)
- gene (5)
- immune response (5)
- in-vitro (5)
- infection (5)
- mice (5)
- proliferation (5)
- protein (5)
- stroke (5)
- virulence (5)
- Ackerschmalwand (4)
- Angiogenese (4)
- B cells (4)
- Dendritische Zelle (4)
- Deutschland (4)
- EEG (4)
- Epigenetik (4)
- Germany (4)
- HIV (4)
- Kernspintomographie (4)
- MRI (4)
- Regulation (4)
- Spintronik (4)
- T cells (4)
- Taufliege (4)
- Tissue Engineering (4)
- Topologischer Isolator (4)
- activation (4)
- blood pressure (4)
- body mass index (4)
- brain (4)
- breast cancer (4)
- cancer treatment (4)
- cell staining (4)
- cells (4)
- children (4)
- fMRI (4)
- immunoprecipitation (4)
- in-vivo (4)
- inflammation (4)
- ischemic stroke (4)
- messenger RNA (4)
- miRNS (4)
- microarray (4)
- molecular docking (4)
- oxidative stress (4)
- platelets (4)
- survival (4)
- therapy (4)
- traumatic brain injury (4)
- ADHD (3)
- Antikörper (3)
- Arteriosklerose (3)
- Aufmerksamkeits-Defizit-Syndrom (3)
- Biodiversität (3)
- Bioinformatik (3)
- Calcium (3)
- Climate Change (3)
- Computational chemistry (3)
- Data Mining (3)
- Diagnostik (3)
- ERP (3)
- Echinococcus (3)
- Entzündung (3)
- Escherichia coli (3)
- Essgewohnheit (3)
- Essverhalten (3)
- Galliumarsenid (3)
- Herzfrequenzvariabilität (3)
- Historische Aufnahme (3)
- Inflammation (3)
- Inhibitor (3)
- Jugend (3)
- Kernspintomografie (3)
- Klimaänderung (3)
- Leistungsbewertung (3)
- Molekularbiologie (3)
- Monoklonaler Antikörper (3)
- Myc (3)
- NF-KAPPA-B (3)
- Netzwerk (3)
- Organische Solarzelle (3)
- Organischer Halbleiter (3)
- Polymere (3)
- Positronen-Emissions-Tomographie (3)
- Quantenpunkt (3)
- RapidEye (3)
- Ratte (3)
- Rechnungslegung (3)
- Rezeptor (3)
- Schmerz (3)
- Signaltransduktion (3)
- Stoffwechsel (3)
- Structural Biology (3)
- TRAIL (3)
- Thrombose (3)
- Trypanosoma brucei (3)
- Universität Würzburg (3)
- Zellzyklus (3)
- amyotrophic-lateral-sclerosis (3)
- analysis of variance (3)
- angiogenesis (3)
- ants (3)
- asthma (3)
- bacteria (3)
- biodiversity (3)
- blood (3)
- blood flow (3)
- burden (3)
- crystal structure (3)
- dSTORM (3)
- diet (3)
- diversity (3)
- dopamine (3)
- drosophila melanogaster (3)
- ecology (3)
- efficacy (3)
- electronic structure (3)
- epithelial cells (3)
- evidence-based medicine (3)
- evolution (3)
- fluorescence (3)
- food-cues (3)
- genome (3)
- growth (3)
- guidelines (3)
- hypertension (3)
- indication for surgery (3)
- kidneys (3)
- laparoscopic ventral hernia repair (3)
- metastasis (3)
- miRNA (3)
- neurons (3)
- neuropathic pain (3)
- obesity (3)
- perioperative management (3)
- platelet activation (3)
- platelet aggregation (3)
- positron emission tomography (3)
- protein domains (3)
- rat (3)
- reveals (3)
- stress (3)
- transcription factors (3)
- (Ga,Mn)As (2)
- 3D (2)
- ADHS (2)
- ARPES (2)
- Achtsamkeit (2)
- Achtsamkeitsbasiertes Training (2)
- Adenosin (2)
- Adenosinrezeptor (2)
- Agrobacterium tumefaciens (2)
- Akt (2)
- Angiotensin II (2)
- Angst (2)
- Antigen CD40 (2)
- Antigen CD8 (2)
- Apoptose (2)
- Aufmerksamkeit (2)
- Autonomous UAV (2)
- B-cells (2)
- Bayern (2)
- Bestäuber (2)
- Bevacizumab (2)
- Bilanzpolitik (2)
- Biomarker (2)
- Biomaterial (2)
- Blutstillung (2)
- Borylene (2)
- CD27 (2)
- CD40 (2)
- CD70 (2)
- Calciumphosphate (2)
- Cancer (2)
- Catecholmethyltransferase <Catechol-0-Methyltransferase> (2)
- China (2)
- Cholesterinstoffwechsel (2)
- Chromatin (2)
- Chronophin (2)
- Click-Chemie (2)
- Compressed Sensing (2)
- DAPI staining (2)
- DNS-Schädigung (2)
- Depression (2)
- Differenzierung (2)
- Diversity (2)
- Docking (2)
- Dopamin (2)
- Drosophila melanogaster (2)
- Duchenne-Syndrom (2)
- Dünne Schicht (2)
- ELISPOT (2)
- ERN (2)
- Einzelhandel (2)
- Elektronentransfer (2)
- Empirische Forschung (2)
- Engagement (2)
- Entwicklung (2)
- Europäische Union (2)
- Evolution (2)
- Excitons (2)
- Farbstoff (2)
- Femtosekundenspektroskopie (2)
- Fernerkundung (2)
- Fettgewebe (2)
- Fettsucht (2)
- Fluoreszenzmikroskopie (2)
- Fotovoltaik (2)
- Gammastrahlung (2)
- Gastric-banding (2)
- Gibbs free energy of binding (2)
- Glioblastoma (2)
- Gliom (2)
- Grammatik (2)
- HNSCC (2)
- Hearing loss (2)
- Herzinfarkt (2)
- Herzinsuffizienz (2)
- Herzmuskelzelle (2)
- Heterostruktur (2)
- Hfq (2)
- Hochauflösendes Verfahren (2)
- Hochauflösung (2)
- Hypertonie (2)
- Hämatopoese (2)
- Hämostase (2)
- Höranstrengung (2)
- Hörverlust (2)
- Immunologie (2)
- Insulin (2)
- Insulinresistenz (2)
- Interference microscopy (2)
- Japankärpfling (2)
- Kilimandscharo (2)
- Kilimanjaro (2)
- Klassifikation (2)
- Knochen-Morphogenese-Proteine (2)
- Kohlenhydrate (2)
- Kollagen (2)
- Krebs <Medizin> (2)
- LASP1 (2)
- LC-MS (2)
- Lagerungsplagiozephalus (2)
- Laparoskopie (2)
- MAP-Kinase (2)
- MRT (2)
- MS (2)
- Makrophage (2)
- Makrophagen (2)
- Manganarsenide (2)
- Maschinelles Lernen (2)
- Massenspektrometrie (2)
- Medizin (2)
- Meeresschwämme (2)
- Melanom (2)
- Merkel cell carcinoma (2)
- Mesenchymzelle (2)
- Mikroporosität (2)
- Mikroskopie (2)
- Multiple myeloma (2)
- Multiples Myelom (2)
- Museum (2)
- Myokardinfarkt (2)
- NET (2)
- Nachhaltigkeit (2)
- Nahfeldoptik (2)
- Nanodiamant (2)
- Nanoröhre (2)
- Nanostruktur (2)
- Neisseria gonorrhoeae (2)
- Neisseria meningitidis (2)
- Nernst-Effekt (2)
- Neurodegeneration (2)
- Onkologie (2)
- Onkolyse (2)
- Optische Spektroskopie (2)
- PALM (2)
- PET (2)
- PRRT (2)
- Parkinson's disease (2)
- Parkinsons disease (2)
- Pemphigus (2)
- Pharmakokinetik (2)
- Phosphatidylinositolkinase <Phosphatidylinositol-3-Kinase> (2)
- Photolumineszenz (2)
- Photostrom (2)
- Photovoltaik (2)
- Plasmozytom (2)
- Platelet (2)
- Platinkomplexe (2)
- Polymerkomplexe (2)
- Polymorphismus (2)
- Positron emission tomography (2)
- Prognose (2)
- Psychische Störung (2)
- Pyracen (2)
- RNA extraction (2)
- RNA-SEQ (2)
- RNS-Spleißen (2)
- Raman-Spektroskopie (2)
- Rashba effect (2)
- Regionalentwicklung (2)
- Renin-Angiotensin-Aldosteron-System (2)
- Rhabdomyosarcoma (2)
- Rituximab (2)
- Scanning microscopy (2)
- Seebeck-Effekt (2)
- Sensor (2)
- Serotonin (2)
- Silicium (2)
- Software Defined Networking (2)
- Sol-Gel-Verfahren (2)
- Splicing (2)
- Sprachentwicklung (2)
- Stammzelle (2)
- Staphylococcus aureus (2)
- State-of-the-Art (2)
- Sternpolymere (2)
- Structure-based drug design (2)
- Strukturbasiertes Wirkstoffdesign (2)
- Synapse (2)
- Systematischer Überblick (2)
- TRIB3 (2)
- TWEAK (2)
- TerraSAR-X (2)
- Therapie (2)
- Tiermodell (2)
- Transcription factor (2)
- Transforming Growth Factor (2)
- Ultrakurzzeitspektroskopie (2)
- West Africa (2)
- Westafrika (2)
- Wirtschaftsprüfung (2)
- Zivilgesellschaft (2)
- absolute configuration (2)
- accelerometer (2)
- actins (2)
- adults (2)
- aging (2)
- akutes Koronarsyndrom (2)
- antigenic variation (2)
- anxiety (2)
- aorta (2)
- apis mellifera (2)
- archaea (2)
- aspergillus fumigatus (2)
- atherosclerosis (2)
- autophagy (2)
- bees (2)
- binding (2)
- bioactivity (2)
- biological locomotion (2)
- biological sciences (2)
- biomarker (2)
- biomarkers (2)
- biosynthesis (2)
- bipolar disorder (2)
- blood-brain barrier (2)
- body weight (2)
- calcium imaging (2)
- carbohydrates (2)
- carcinomas (2)
- cell cultures (2)
- central nervous system (2)
- chemokines (2)
- chemotherapy (2)
- chronic kidney disease (2)
- clothing (2)
- communication (2)
- comparative genomics (2)
- complex (2)
- consciousness (2)
- crosstalk (2)
- culture (2)
- cytotoxic T cells (2)
- death rates (2)
- density functional theory (2)
- depression (2)
- dereplication (2)
- diagnosis (2)
- diagnostic medicine (2)
- dieting success (2)
- differentiation (2)
- down regulation (2)
- drug delivery (2)
- eating behavior (2)
- echocardiography (2)
- electrochemistry (2)
- energy metabolism (2)
- enzyme-linked immunoassays (2)
- epidemiology (2)
- epigenetics (2)
- event-related potentials (2)
- factor XII (2)
- factor-I (2)
- fish model (2)
- follicular lymphoma (2)
- follow-up (2)
- foraging (2)
- fungal structure (2)
- fungi (2)
- gait (2)
- games (2)
- gastric cancer (2)
- gene regulation (2)
- genes (2)
- glioma (2)
- glutathione (2)
- glycolysis (2)
- green fluorescent protein (2)
- gyroscope (2)
- heart (2)
- hospitalizations (2)
- human (2)
- humans (2)
- identification (2)
- immunohistochemistry techniques (2)
- inhibition (2)
- inhibitors (2)
- integrins (2)
- interference (2)
- leishmaniasis (2)
- lipid bilayer (2)
- lung and intrathoracic tumors (2)
- lymphocytes (2)
- macrophage (2)
- macrophages (2)
- man-computer interface (2)
- management (2)
- mass spectrometry (2)
- meiosis (2)
- melanoma (2)
- membrane (2)
- membrane proteins (2)
- messenger-RNA (2)
- midazolam (2)
- model (2)
- molecular beam epitaxy (2)
- multiple sclerosis (2)
- mutations (2)
- myocardial infarction (2)
- necrosis-factor-alpha (2)
- nervous system (2)
- neuroscience (2)
- nutrition (2)
- oncolytic viruses (2)
- opioids (2)
- organization (2)
- oscillation (2)
- outbreak (2)
- ovarian cancer (2)
- oxygen uptake (2)
- oxygenation (2)
- panic disorder (2)
- perception (2)
- photoelectron spectroscopy (2)
- photoluminescence (2)
- phylogenetic analysis (2)
- phylogenetic trees (2)
- plasmodium falciparum (2)
- pollination (2)
- polymerase chain reaction (2)
- polyneuropathy (2)
- poor prognosis (2)
- population (2)
- positron-emission-tomography (2)
- prediction (2)
- predictive value (2)
- prefrontal cortex (2)
- prognosis (2)
- progression (2)
- prostate cancer (2)
- protein aggregation (2)
- protein-protein interactions (2)
- proteins (2)
- pulmonary hypertension (2)
- pyracene (2)
- quality (2)
- recruitment (2)
- regulatory T cells (2)
- relapse (2)
- remote sensing (2)
- renal cancer (2)
- replication (2)
- resistance (2)
- responses (2)
- risk (2)
- risk factors (2)
- saccharomyces cerevisiae (2)
- scFv (2)
- scanning electron microscopy (2)
- scanning tunneling microscopy (2)
- secondary lung tumors (2)
- secretion (2)
- sepsis (2)
- sequence (2)
- sequence alignment (2)
- sex chromosomes (2)
- sleep (2)
- small interfering RNAs (2)
- solar cells (2)
- spin–orbit coupling (2)
- sponges (2)
- staphylococcus aureus (2)
- stem-cell transplantation (2)
- strains (2)
- stress resistance (2)
- stromal cells (2)
- super-resolution (2)
- superconductivity (2)
- surgical oncology (2)
- susceptibility (2)
- synaptic plasticity (2)
- target (2)
- telomeres (2)
- textile (2)
- time series (2)
- tissue saturation index (2)
- topological insulators (2)
- topologische Isolatoren (2)
- transcription (2)
- transcriptome (2)
- transcriptomics (2)
- transplantation (2)
- tumor (2)
- type 2 diabetes (2)
- tyrosine (2)
- ubiquitination (2)
- validation (2)
- venous system (2)
- video analysis (2)
- virtual reality (2)
- weight loss (2)
- young children (2)
- γδ T cells (2)
- "-omics" (1)
- (6,5)-SWNT (1)
- 11-beta-Hydroxylase (1)
- 17beta-Estradiol (1)
- 17beta-estradiol (1)
- 18-F-fluorothymidine uptake (1)
- 18FDG-PET/CT (1)
- 2 PM (1)
- 2-APB (1)
- 2-Methylallyl (1)
- 2-methylallyl (1)
- 3 Tesla (1)
- 3D Sensor (1)
- 3D Vision (1)
- 3D microscopy (1)
- 3D models (1)
- 3D-Pulverdruck (1)
- 3′ UTR (1)
- 5-Fluorouracil (1)
- 5-HT1A receptor (1)
- 5-bromodeoxyuridine (1)
- 5IA-SPECT (1)
- 60-nucleotide duplication (1)
- 6DOF Pose Estimation (1)
- 8-Oxo-2’-desoxyguanosin (1)
- 8-oxo-2'-deoxyguanosine (1)
- 9-Oxabispidin (1)
- 9-oxabispidine (1)
- A-D (1)
- AAER (1)
- AAPA (1)
- AAT (1)
- ABL gene (1)
- ABR Monitoring (1)
- ACH-2 (1)
- ACS (1)
- AG(110) (1)
- AL amyloidosis (1)
- AL-Amyloidose (1)
- ALCL (1)
- ALS (1)
- AMISOM (1)
- ANOVA (1)
- ANP (1)
- APCE (1)
- AQP (1)
- AQP4 (1)
- ARDS (1)
- ARF tumor-suppressor induced lymphomagenes (1)
- ARFIMA-Modell (1)
- ARFIMA-Modelle (1)
- ARMA-Modell (1)
- ART outcome (1)
- ASSET4 (1)
- ATG (1)
- ATG8 (1)
- ATLAS <Teilchendetektor> (1)
- ATM gene (1)
- ATP-binding cassette transporter (1)
- AVHRR (1)
- AVHRR data (1)
- Aberration (1)
- Abformmaterial (1)
- Abformung (1)
- Abschlussprüferhonorar (1)
- Absolute Configuration (1)
- Absolute Konfiguration (1)
- Absolutquantifizierung (1)
- Accelerometry (1)
- Ackerrandstreifen (1)
- Acromiopectorallappen (1)
- Actinoide (1)
- Actinokineospora (1)
- Action Research (1)
- Action feedback (1)
- Activin (1)
- Adaptation (1)
- Adapterprotein (1)
- Addiction (1)
- Adduct Complex (1)
- Addukt (1)
- Adduktbildung (1)
- Adenosine (1)
- Adenosine receptor (1)
- Adenylatcyclaseassay (1)
- Adipose Tissue (1)
- Adipositas (1)
- Adolescence (1)
- Adolf Hurwitz (1)
- Adsorptionsschicht (1)
- Adult (1)
- Adulte Stammzelle (1)
- African Trypanosomes (1)
- African Union (1)
- Afrika (1)
- Afrikanische Union (1)
- Aggregation (1)
- Agricultural land use (1)
- Aktien (1)
- Aktionsforschung (1)
- Aktive Zonen (1)
- Aktiver galaktischer Kern (1)
- Akustikusneurinom (1)
- Akute myeloische Leukämie (1)
- Akzeptorgruppe (1)
- Akzessibilität (1)
- Alanyl-Aminopeptidase (1)
- Aldosteron (1)
- Alexander von Wagner (1)
- Algebraic Curves (1)
- Algebraische Kurve (1)
- Alginat (1)
- Alginate (1)
- Alignment (1)
- Alignment <Biochemie> (1)
- Aliphaten (1)
- Alkalidotierte Calciumphosphatcemente (1)
- Alkaline phosphatase (1)
- Alkoholkonsum (1)
- Alkoholmissbrauch (1)
- Allergie (1)
- Alloantigenerkennung (1)
- Allophrynidae (1)
- Alpaca (1)
- Alternative Medizin (1)
- Alternative methods (1)
- Alternativmedizin (1)
- Alternativmethoden (1)
- Alterstraumatologie (1)
- Alterung (1)
- Alzheimer’s disease (1)
- Ameisen (1)
- Aminobisphosphonate (1)
- Aminoborylenkomplexe (1)
- Aminobuttersäure <gamma-> (1)
- Aminopenicilline (1)
- Amphiphile Verbindungen (1)
- Amu Darya (1)
- Amyloidose (1)
- Analgesia (1)
- Analgesie (1)
- Analysis of Variance (1)
- Anaphylaxis (1)
- Aneuploidy (1)
- Angiogenesis (1)
- Angle-Klasse III (1)
- Animal model (1)
- Anlegerschutz- und Funktionsverbesserungsgesetz (1)
- Anorganische Chemie (1)
- Anpassung (1)
- Anschleichen (1)
- Antenne (1)
- Anterior cruciate ligament (1)
- Anthracenderivate (1)
- Anthrachinonderivate (1)
- Antiangiogenese (1)
- Antibiotikum (1)
- Antibodies (1)
- Anticoagulants (1)
- Antiferromagnetismus (1)
- Antigen (1)
- Antigen CD4 (1)
- Antiinfektiva (1)
- Antimikrobieller Wirkstoff (1)
- Antimonverbindungen (1)
- Antipodes (1)
- Anura (1)
- Aortenklappenstenose (1)
- Approach-Avoidance-Task (1)
- Approximationsalgorithmus (1)
- Aquaporin 4 (1)
- Arabidopsis thaliana (1)
- Arbeitsablaufplanung (1)
- Arginine (1)
- Argonaute (1)
- Arten-Energy-Theory (1)
- Arterial Diameters (1)
- Arteriogenese (1)
- Arzneimitteldesign (1)
- Arzneimittelforschung (1)
- Aseptic loosening (1)
- Aspergillus fumigatus (1)
- Association (1)
- Assoziation (1)
- Astrocytic tumor (1)
- Astrozytom (1)
- Asymmetrie (1)
- Asymmetrische Synthese (1)
- Atemluftanalyse (1)
- Atemwege (1)
- Atherosclerosis (1)
- Atherosklerose (1)
- Atomic-force-microscopy (1)
- AtrbohD (1)
- Atriales natriuretisches Hormon (1)
- Atriales natriuretisches Peptid (1)
- Attention deficit / hyperactivity disorder (1)
- Attraktivität (1)
- Audiologie (1)
- Aufgabenwechsel (1)
- Aufmerksamkeitsdefizit-Syndrom (1)
- Aufmerksamkeitslenkung (1)
- Aufsatzsammlung (1)
- Aufsichtsrat (1)
- Auftauschicht (1)
- Aurora B (1)
- Auslandsgesellschaft (1)
- Autoaggressionskrankheit (1)
- Autoantikörper (1)
- Autoimmundermatose (1)
- Autoimmunerkrankung (1)
- Autoimmunität (1)
- Automatische Annäherungstendenzen (1)
- Autonomer Roboter (1)
- Autoreduzierbarkeit (1)
- Autotransporterprotein (1)
- Außenwirtschaftspolitik (1)
- Azine / Diazine (1)
- B cell receptors (1)
- B-Lymphozyt (1)
- B-Zell-Lymphom (1)
- BBL (1)
- BCL-X-L P53 (1)
- BCR-ABL (1)
- BDNF (1)
- BEGIN stimuli (1)
- BETA(2)-adrenergic receptor (1)
- BH3-only proteins (1)
- BK-Kanal (1)
- BMD (1)
- BMP (1)
- BTN3 (1)
- BTN3A1 and Phospho-antigen presentation (1)
- BYL-719 (1)
- Bach (1)
- Bacteria (1)
- Bakterien (1)
- Baltic Sea (1)
- Bambi (1)
- Bandscheibenerkrankung (1)
- Bandscheibenkrankheit (1)
- Bank (1)
- Barbed suture (1)
- Barbed suture material (1)
- Bariatric surgery (1)
- Bariatrische Chirurgie (1)
- Beckenbodensenkung (1)
- Becker-Kiener-Syndrom (1)
- Bedarfserhebung (1)
- Befragung von Menschen mit geistiger Behinderung (1)
- Bekleidungsvorschriften (1)
- Benzimidazoles (1)
- Berger-Parker (1)
- Bericht (1)
- Beschaffung (1)
- Beschallung (1)
- Bestimmung des Relaxations-Parameters in der Magnetresonanztomografie (1)
- Bestäubungsökologie (1)
- Beta-1-Rezeptor (1)
- Beteiligungspublizität (1)
- Beteiligungstransparenz (1)
- Bevölkerung / Sozialstruktur (1)
- Bewertung (1)
- Bharatiya Janata Party (1)
- Bias (1)
- Bibel. Judit (1)
- Bibliometrie (1)
- Bienen <Überfamilie> (1)
- Bildauflösung (1)
- Bilderkennnung (1)
- Bilderkennung (1)
- Bilderzeugung (1)
- Bildgebendes Verfahren (1)
- Bildgebung (1)
- Bildverarbeitung (1)
- Bilharziose (1)
- Bindungsaktivierung (1)
- Bindungsaktivierung <Chemische Bindung> <Aktivierung, Chemie> (1)
- Bindungsassay (1)
- Bingel-Hirsch-Reaktion (1)
- Bioanorganische Chemie (1)
- Bioengineering (1)
- Bioinformatics (1)
- Bioisosterie (1)
- Biologische Uhr (1)
- Biomedicine (1)
- Biomembran (1)
- Bioreactor System (1)
- Bioreaktor (1)
- Biosphärenreservat Sian Ka'an (1)
- Bipolar disorder (1)
- Bipolare Störung (1)
- Bismut (1)
- Bisphosphonates (1)
- Bispidin (1)
- Bispidinderivate (1)
- Blattflächenindex (1)
- Blattschneiderameisen (1)
- Blazar (1)
- Blei (1)
- Blut-Luft-Schranke (1)
- Board of directors (1)
- Bodennutzung (1)
- Bombus (1)
- Bombus Spp. Hymenoptera (1)
- Bone Morphogenetic Proteins (1)
- Bone regeneration (1)
- Bone tumor (1)
- Bor (1)
- Bordetella pertussis (1)
- Borheterocyclen (1)
- Borneo (1)
- Borole (1)
- Bortezomib (1)
- Boryl Anion (1)
- Borylentransfer (1)
- Bos taurus (1)
- Botanischer Garten (1)
- Brain (1)
- Brain-computer interface (1)
- Brassica napus (1)
- BrdU (1)
- Breast cancer cells (1)
- Bridging (1)
- Brustdrüse (1)
- Brustdrüsenentzündung (1)
- Brustkrebs (1)
- Brüder Hurwitz (1)
- Budgetrecht (1)
- Bumblebee (1)
- Burkholderia (1)
- Burkholderia pseudomallei (1)
- Burkitt Lymphom (1)
- Burkitt Lymphoma (1)
- Burma (1)
- Butterfly (1)
- Bürgerbeteiligung (1)
- C(-1019)G polymorphism (1)
- C-13-metabolic flux analysis (1)
- C-MYC (1)
- C-MYC PUMA (1)
- C-Terminus (1)
- C/EBPβ (1)
- C/Si-Austausch (1)
- C1-inhibitor (1)
- C57BL/6 mice (1)
- C6 (1)
- CASP (1)
- CASPASE-3 (1)
- CCD (1)
- CCDC79 (1)
- CCL2 (1)
- CCN1 (1)
- CD coreceptors (1)
- CD-Spektroskopie (1)
- CD/metabolism (1)
- CD150 (1)
- CD20 (1)
- CD39 (1)
- CD4(+) (1)
- CD4(+) T-cells (1)
- CD40 gerichteter bifunktioneller scFv-TRAIL Fusionsproteine (1)
- CD40 ligand (1)
- CD40-targeted bifunctional scFv-TRAIL fusion proteins (1)
- CD40L (1)
- CD46 (1)
- CD68 (1)
- CD73 (1)
- CD8(+) (1)
- CD8+ T cells (1)
- CD8+ T-Zellen (1)
- CK2 (1)
- CLAVATA3 (1)
- CLEC-2 ITAM (1)
- CML (1)
- CNS Myelination (1)
- CNVs (1)
- COMPLEX 1 (1)
- COMT (1)
- COMT polymorphism (1)
- COMT-Polymorphismus (1)
- CORMs (1)
- CPP-GMR (1)
- CRKL (1)
- CSVD (1)
- CT-gesteuerte Punktion (1)
- CTGF (1)
- CVD Synthese (1)
- CYP11A1 (1)
- CYP11B1 (1)
- CYP11B2 (1)
- CYP2W1 (1)
- CYR61 (1)
- Ca2+ release activated Ca2+ channel (1)
- Calciumhomöostase (1)
- Calciumkanal (1)
- Calciumtransport (1)
- Caloritronic (1)
- Cancer treatment (1)
- Candida albicans (1)
- Candidate Phylum Poribacteria (1)
- Cardiac hypertrophy (1)
- Cardiomyocytes (1)
- Carfilzomib (1)
- Caroticoclinoid-Foramen (1)
- Carotisdoppler (1)
- Carotisstenose (1)
- Carrier envelope phase effects (1)
- Cartesio (1)
- Cascades (1)
- Caspase 3/7 activity (1)
- Catechine (1)
- Catenine (1)
- Cav2.2 (1)
- Cell Cycle (1)
- Cell viability, (1)
- Cellular invasion (1)
- Central Asia (1)
- Central venous access (1)
- Centrolenidae (1)
- Cerebrospinal fluid (CSF) (1)
- Cestoda (1)
- Cestode (1)
- ChIP-Seq (1)
- Charcot-Marie-Tooth disease (1)
- Charge Carrier Generation (1)
- Charges recombination (1)
- Chemische Synthese (1)
- Chemokin CXCL10 (1)
- Chemotherapy (1)
- Chiralität <Chemie> (1)
- Chirurgie (1)
- Chlamydia (1)
- Chlamydia trachomatis (1)
- Chlamydia-trachomatis-Infektion (1)
- Chlorinderivate (1)
- Cholezystektomie (1)
- Chondrosarcoma (1)
- Chromosom 6 (1)
- Chromosomal Passenger Complex (1)
- Chromosome 6 (1)
- Chronic Mild Stres (1)
- Chronic disease (1)
- Chronic kidney disease (1)
- Chronische Herzinsuffizienz (1)
- Chronobiologie (1)
- Circadian Rhythms (1)
- Civil Society (1)
- Claudin-1 (1)
- Climate (1)
- Clinical psychotherapy (1)
- Cloud Gaming (1)
- Cluster <Wirtschaft> (1)
- Cluster-Offensive-Bayern (1)
- Clusterorganisation (1)
- Clusterplattform (1)
- Clusterpolitik (1)
- Co-Determination (1)
- Coagulation factor IX (1)
- Cochleaimplantat (1)
- Coexpression (1)
- Cognitive control (1)
- Collybistin (1)
- Colonkrebs (1)
- Columnare Phase (1)
- Combination therapy (1)
- Complex Continued Fractions (1)
- Computational physics (1)
- Computer Vision (1)
- Computerphysik (1)
- Computertomograph (1)
- Computertomographie (1)
- Conditioned inhibition (1)
- Conditioning (1)
- Conjugate function (1)
- Connective Tissue Growth Factor (1)
- Continental (1)
- Convoy Protection (1)
- Cooperative UAV (1)
- Copy number variation (1)
- Cord blood-derived hematopoietic stem and progenitor cells (1)
- Corporate Financial Performance (1)
- Corporate Governance (1)
- Corporate Sustainability (1)
- Correlates (1)
- Costa Rica (1)
- Coulomb-Blockade (1)
- Coumarin (1)
- Coupled-Cluster Theory (1)
- Coupled-Cluster-Theorie (1)
- Craving (1)
- Creatin Kinase (1)
- Crohns-disease (1)
- Cross-species analyses (1)
- Crosstalk (1)
- Crusaders (1)
- CsrA (1)
- CuAAC 'click' reaction (1)
- Cue (1)
- Cushing’s syndrome (1)
- Cutinase (1)
- Cyclo-AMP (1)
- Cyclophosphamide (1)
- Cytokine (1)
- Cytokines (1)
- Cytoskeleton Chromosomal Passenger Complex Interaction GAR Domain (1)
- D insufficiency (1)
- D serum-levels (1)
- DC optimization (1)
- DEL(5Q) (1)
- DETC (1)
- DHAP (1)
- DLBCL (1)
- DLX5/6 (1)
- DM-domain gene (1)
- DMD (1)
- DMS (1)
- DNA (1)
- DNA Repair (1)
- DNA base excision repair (1)
- DNA damage (1)
- DNA glycosation (1)
- DNA lesion (1)
- DNA methylation (1)
- DNA methyltransferase gene (1)
- DNA repair (1)
- DNA repair protraction (1)
- DNA-Basen (1)
- DNA-Methylierung (1)
- DNA-Reparatur (1)
- DNA-binding domain (1)
- DNA-binding proteins (1)
- DNA-damage checkpoint (1)
- DNMT3A (1)
- DNMT3B (1)
- DNS (1)
- DNS-Bindung (1)
- DNS-Reparatur (1)
- DNS-Schaden (1)
- DOPA-responsive-dystonia (1)
- DOT1 methyltransferase (1)
- DPR Deutsche Prüfstelle für Rechnungslegung (1)
- DRG (1)
- DRG-System (1)
- DSM-5 (1)
- DSM-IV (1)
- DVT (1)
- DWI (1)
- DYNC1I1 (1)
- Daniel <Buch 1 - 6> (1)
- Das Nibelungenbuch (1)
- Data Fusion (1)
- Data Quality (1)
- Datenqualität (1)
- Dauerfrostboden (1)
- Deceased Donor Score (1)
- Decentralized formation control (1)
- Deep sequencing (1)
- Demethylierung (1)
- Dendrimere (1)
- Dendrimers (1)
- Dendritische Zellen (1)
- Dengue (1)
- Dentalimplantat (1)
- Dentalwerkstoff (1)
- Dependenz (1)
- Der Granatapfelbaum (1)
- Deregulierung (1)
- Descensus (1)
- Descensus uteri (1)
- Descensus vaginalis (1)
- Descensuschirurgie (1)
- Desmoglein 2 (1)
- Desmoglein 3 (1)
- Desmogleine (1)
- Deutsch (1)
- Deviseninterventionen (1)
- Dexamethason (1)
- Dezentralisierung (1)
- Diabetes mellitus / Typ 2 (1)
- Diabetes mellitus / Typ II (1)
- Diboren (1)
- Dichtegradient (1)
- Dichtegradientenzentrifugation (1)
- Die Nibelungen (Film) (1)
- Died Blood Spot (1)
- Died Plasma Spots (1)
- Diels–Alder reaction (1)
- Differential GPS (DGPS) (1)
- Differentielle Genexpression (1)
- Differentielle Wirkungspfade (1)
- Digitale Volumentomographie (1)
- Digitalisierung (1)
- Dilatative Kardiomyopathie (1)
- Dimension 3 (1)
- Dimerisierung (1)
- Directed Flight (1)
- Disordered semiconductor (1)
- Dispergierung (1)
- Dissemination (1)
- Distributed Control (1)
- Domain-specific approach (1)
- Domäne <Biochemie> (1)
- Donor-Score (1)
- Donorgruppe (1)
- Dopamin-Transporter (1)
- Dopamine transporter (1)
- Dreidimensionales Bild (1)
- Dreiecksgitter (1)
- Driver Assistance Systems (1)
- Drosophila (1)
- Drought (1)
- Drug allergy (1)
- Drug reaction (1)
- Dual RNA-seq (1)
- Dual gap function (1)
- Dualitätstheorie (1)
- Durchflusscytometrie (1)
- Durchsetzung der Rechnungslegung (1)
- Dutch Disease (1)
- Dynamic stopping (1)
- Dynein Light Chain (1)
- Dyson orbitals (1)
- Dysplasie (1)
- E-Bonds (1)
- E-Learning (1)
- E. coli Nissle (1)
- E2F3 (1)
- EAAT2 (1)
- EAE (1)
- EBM (1)
- EGFR (1)
- EHEC (1)
- EKG (1)
- EL-4 Zellen (1)
- END stimuli (1)
- EPC (1)
- EPG (1)
- ERCC1-XPF (1)
- ERCC4 (1)
- ERK (1)
- ERK signaling cascade (1)
- ERM proteins (1)
- ERPs (1)
- ESG (environmental, social, governance) (1)
- ESM (1)
- Eap (1)
- Early Posterior Negativity (1)
- Early collision warning (1)
- Echinococcosis (1)
- Echinococcus multilocularis (1)
- Ectopic bone formation (1)
- Effekte der absoluten Phase (1)
- Effizienz (1)
- Ehrenamtliche Tätigkeit (1)
- Eigeninjektion / self injection (1)
- Einfluss (1)
- Einkauf (1)
- Einkaufszentrum (1)
- Einmodenlaser (1)
- Einzel-Molekül (1)
- Einzelhandelsstrukturen (1)
- Einzelmolekülmikroskopie (1)
- Einzelmolekülspektroskopie (1)
- Einzelphotonenemisson (1)
- Elastin (1)
- Elections in India (1)
- Electron Transfer (1)
- Electronic Circular Dichroism (1)
- Elektroakupunktur (1)
- Elektrochemie (1)
- Elektrodenanordnung (1)
- Elektroencephalographie (1)
- Elektron-Transfer (1)
- Elektronen Tunneln (1)
- Elektronenspin (1)
- Elektronensprayionisations-Massenspektrometrie (1)
- Elektronenstruktur (1)
- Elektronentransport (1)
- Elektronische Eigenschaft (1)
- Elektronische Nase (1)
- Elektronischer Circulardichroismus (1)
- Elektrophysiologie (1)
- Elektrospinning (1)
- Elternarbeit (1)
- Elternbildung (1)
- Elterntraining (1)
- Embodied Cleansing (1)
- Embodied Cognition (1)
- Embodiment (1)
- Embryonale Stammzelle (1)
- Embryonale Stammzellen (1)
- Emotionales Essverhalten (1)
- Emotionales Eßverhalten (1)
- Emotionsregulation (1)
- Emotionsverarbeitung (1)
- Empirical Analysis (1)
- Enantioselektivität (1)
- Encephalomyelitis (1)
- Endocytose (1)
- Endogenous opioids (1)
- Endothelzelle (1)
- Endpoint Mobility (1)
- Energie-Transfer (1)
- Energy Harvesting (1)
- Energy Transfer (1)
- Engadin (1)
- Enhancement (1)
- Enterale Ernährung (1)
- Entnahmemorbidität (1)
- Entwicklung im 2. und 3. Lebensjahr, Entwicklungsdokumentation, Pikler, Pikler-Konzept, Beobachtungsbogen (1)
- Environmental Performance (1)
- Enzyme-linked immunosorbent assay (1)
- EpCAM (1)
- Epigenetic (1)
- Erdrutsch (1)
- Ereigniskorrelierte Potentiale (1)
- Ereigniskorreliertes Potenzial (1)
- Erk (1)
- Ernährung (1)
- Erwachsener (1)
- Erwinia amylovora (1)
- Erziehung (1)
- Erziehungsstil (1)
- Escherichia coli infections (1)
- Escherichia coli-Hfq (1)
- Escherichia coli-derived recombinant human bone morphogenetic protein-2 (1)
- Estradiol (1)
- Ethnografie des Sprechens (1)
- Ethnografische Beschreibung der Mennoniten-Kolonie Fernheim in Paraguay (1)
- Ethnographie of the Mennonite colony Fernheim in Paraguay (1)
- Ethnography of communication (1)
- Etomidat (1)
- Euro-GmbH (1)
- Euroanleihe (1)
- Eurobonds (1)
- Europa-GmbH (1)
- Europarecht (1)
- Europe (1)
- European Private Company (1)
- Europäische Grundfreiheiten (1)
- Europäische Privatgesellschaft (1)
- Europäische Union / Außenpolitik (1)
- Evaluation (1)
- Event-related potentials (1)
- Excited states spectroscopy (1)
- Exekutive Funktionen (1)
- Exercise testing (1)
- Exon Array (1)
- Exotics (1)
- Experimental Autoimmune Encephalomyelitis (EAE) (1)
- Experimental Physics (1)
- Experimental physics (1)
- Experimentelle Autoimmune Enzephalomyelitis (EAE) (1)
- Explorative analyses (1)
- Expression (1)
- Extrakorporale Befruchtung (1)
- Extraocular eye muscles (1)
- Extraversion (1)
- Extrazelluläre Matrix (1)
- Extremwert (1)
- Eysenck (1)
- FACS (1)
- FADD (1)
- FANCP (1)
- FAP alpha (1)
- FBXO6 (1)
- FDG-PET (1)
- FDG-PET/CT (1)
- FISH (1)
- FLS2 receptor (1)
- FLT-PET (1)
- FMRI (1)
- FNIRS (1)
- FOSL1 (1)
- FOSMN (1)
- FREP (1)
- Fabrication (1)
- Fabry disease (1)
- Face-Konzept nach Goffman (1)
- Facial EMG (1)
- Fahrerassistenz (1)
- Fahrerassistenzsysteme (1)
- Fanconi Anemia (1)
- Fanconi-Anämie (1)
- Fas-Signalweg (1)
- Fbw7 (1)
- Fear conditioning (1)
- Feature-Selection (1)
- Feedback-Generierung (1)
- Fehlermonitoring (1)
- Fehlerverarbeitung (1)
- Feldstärke (1)
- Fermi-Flüssigkeit (1)
- Fermionensystem (1)
- Ferroelektrikum (1)
- Festkörperchemie (1)
- Festkörperoberfläche (1)
- Fettsäure (1)
- Fibrin (1)
- Fibroblasten-Aktivierungs-Protein Alpha (1)
- Fibromyalgia syndrome (1)
- Fibromyalgie (1)
- Fibrose (1)
- Filter (1)
- Finanzierung (1)
- Finanzkrise (1)
- Finite Elemente (1)
- Fisher-Score (1)
- Flexor tendon repair (1)
- Fluorescence Upconversion (1)
- Fluoreszenz (1)
- Fluoreszenz Aufkonversion (1)
- Fluoreszenzlöschung (1)
- Flüssigkristall (1)
- Foldamere (1)
- Foldamers (1)
- Food Carvings Questionnaire (1)
- Food Cravings Questionnaires (1)
- Food craving (1)
- Forest management (1)
- Foxp3+CD4+ regulatorische T-Zelle (1)
- Foxp3+CD4+ regulatory T cell (1)
- Fraktionale Integration (1)
- Frakturschrift (1)
- Franz von Kutschera (1)
- Freiburg Speech Test (1)
- Freiburger Einsilbertest (1)
- Freiburger Sprachtest (1)
- Freisetzungskinetik (1)
- Freizügigkeit (1)
- French-Canadian patients (1)
- Froschlurche (1)
- Fructose (1)
- Fruktose (1)
- Frustration (1)
- Frustrierter Magnetismus (1)
- Frühe Kollisionswarnungen (1)
- Fuchsbandwurm (1)
- Function (1)
- Function Fields (1)
- Functional analyses (1)
- Funktion (1)
- Funktionalisierung <Chemie> (1)
- Funktionelle Annotation (1)
- Funktionelle Kernspintomographie (1)
- Funktionenkörper (1)
- Fzd3 (1)
- G protein-coupled receptor (1)
- GAAS (1)
- GABA (1)
- GAS2L3 (1)
- GC-A (1)
- GC-MS (1)
- GCH1 (1)
- GFP (1)
- GH response (1)
- GIS-based Modelling (1)
- GLV-1 h153 (1)
- GPS Reciever (1)
- GTL2 (1)
- GUT (1)
- GVHD (1)
- GWAS (1)
- Galectine (1)
- Galliumarsenid-Bauelement (1)
- Galois theory (1)
- Galoistheorie (1)
- Gamet (1)
- Gamma-Burst (1)
- Gammaastronomie (1)
- Gastrulation (1)
- Gebirgspermafrost (1)
- Gebärmutterhalskrebs (1)
- Gecko (1)
- Geistigbehindertenpädagogik (1)
- Geldpolitik (1)
- Geleitzug (1)
- Gelfilm (1)
- Gemeinsame Afrika-EU-Strategie (1)
- Gen notch (1)
- Gen-Knockout (1)
- Gene regulation (1)
- Gene sets (1)
- Gene therapy (1)
- General Circulation Model (1)
- General amplifier model (1)
- Generalized Nash equilibrium (1)
- Generalized Probabilistic Theories (1)
- Generic questionnaire (1)
- Genetics (1)
- Genetik (1)
- Genotype-phenotype association (1)
- Genregulation (1)
- Gentoxizität (1)
- Genyue ji (1)
- Geoinformationssystem (1)
- Geophysics (1)
- Geophysikalische Methoden (1)
- Gephyrin (1)
- Gerinnungsfaktor XII (1)
- Germanium (1)
- Germinative cell (1)
- Geschichte (1)
- Geschichte 2014 (1)
- Geschlechtsbestimmung (1)
- Gesellschaftsrecht (1)
- Gesellschaftsstatut (1)
- Gesicht (1)
- Gesprächsanalyse (1)
- Gesundheitsgefährdung (1)
- Gesundheitsökonomie (1)
- Gewalt (1)
- Gewalttätigkeit (1)
- Gewebecharakterisierung (1)
- Gewebekultur (1)
- Gewährleistungsübernahme (1)
- Giantmagnetoresistance (1)
- Glacier forefield (1)
- Glatiramer acetate (1)
- Gletschervorfeld (1)
- GlideScope-Videolaryngoskop (1)
- GlideScope-videolaryngoscope (1)
- Glioblastom (1)
- Glioblastoma cell line (1)
- Glioblastoma multiforme (1)
- Glioma (1)
- Gliotoxin (1)
- Global Navigation Satellite System (GNSS) (1)
- Global Positioning System (GPS) (1)
- Glucocorticosteroide (1)
- Glucosetransporter (1)
- Glucosetransportproteine (1)
- Glutamat-Decarboxylase (1)
- Glutamatrezeptor (1)
- Glutathion (1)
- Glutathione (1)
- Glykane <N-> (1)
- Glykosylierung (1)
- Glykosyltransferase (1)
- Gonadenentwicklung (1)
- Graph (1)
- Graphenzeichnen (1)
- Grasses (1)
- Graves disease (1)
- Grenzüberschreitende Sitzverlegung (1)
- Grippe (1)
- Ground surface temperature (1)
- Group therapy (1)
- Grundfreiheit (1)
- Grundfrequenz (1)
- Grundfrequenzparameter (1)
- Grundlage (1)
- Grundlagen der Quantentheorie (1)
- Gruppentherapie (1)
- Guanylatzyklase (1)
- Guanylylcyclase (1)
- Guillain-Barre-Syndrome (1)
- H-Dimerbildung (1)
- HAD phosphatase (1)
- HCV genotype-2 (1)
- HER2 (1)
- HERV-K (1)
- HIP osteoarthritis (1)
- HIV-1 (1)
- HIV-1 protease (1)
- HIV-Infektion (1)
- HIV-associated neurocognitive disorder (HAND) (1)
- HIV-assoziierte neurokognitive Störung (HAND) (1)
- HPA Axis (1)
- HUWE1 (1)
- Halb-Heusler Legierung NiMnSb (1)
- Halbleiter (1)
- Halbleiterphysik (1)
- Half Heusler alloy NiMnSb (1)
- Haloacid dehalogenase (1)
- Halofuginon (1)
- Halothane (1)
- Handlungswirksamkeit (1)
- Haplotyp (1)
- Haplotypanalyse (1)
- Harmonic (1)
- Harnwegsinfektion (1)
- Harte Röntgenstrahlung (1)
- Hashimoto Thyreoiditis (1)
- Hashimoto-Thyreoiditis (1)
- Hauptgruppenelement (1)
- Haut (1)
- Haydn, Joseph (1)
- HbA1c (1)
- HeLa cells (1)
- Head (1)
- Health promotion (1)
- Health-determinants (1)
- Heathen world (1)
- Heavy Fermion Systems (1)
- Heidentum <Motiv> (1)
- Heidenwelt (1)
- Heilung (1)
- Heißhunger (1)
- Helferzelle (1)
- Helmtherapie (1)
- Hematopoietic stem cell ex-vivo expansion (1)
- Hemmung (1)
- Herbivory (1)
- Hernie (1)
- Herstellung (1)
- Herzchirurgie (1)
- Herzkatheter (1)
- Herzrhythmusstörungen (1)
- Herzruptur (1)
- Herzthoraxchirurgie (1)
- Hesse (1)
- Heteroaromaten (1)
- Heterocyclische Carbene <-N> (1)
- Heusler (1)
- Heuslersche Legierung (1)
- Hexagonaler Kristall (1)
- Hey Proteine (1)
- Hey proteins (1)
- HgTe (1)
- Hickman catheter (1)
- Hidden-Markov-Modell (1)
- Hidden-Order of URu2Si2 (1)
- High throughput screening (1)
- High-fat diet (1)
- Higher-coordinate Compounds (1)
- Hill's powers (1)
- Hirninfarkt (1)
- Hirnstammimplantat (1)
- Hirntumor (1)
- Hirschsprung disease (1)
- Histon-Demethylase UTX (1)
- Histon-Methyltransferase (1)
- Histone (1)
- Historische Geographie (1)
- Hitzeschock-Proteine (1)
- Hochdurchsatzsequenzierung (1)
- Hochenergieastronomie (1)
- Hochfeld (1)
- Hochmittelalter (1)
- Hochschulbildung (1)
- Hochschulschrift (1)
- Honeybee (1)
- Honigwabengitter (1)
- Host-parasite interaction (1)
- Host-pathogen interactions (1)
- Hsp70 (1)
- Huayanggong jishi (1)
- Hubbard model (1)
- Hubbard-Modell (1)
- Hubbard-model (1)
- Human (1)
- Human endogenous retrovirus (1)
- Hurwitz spaces (1)
- Hurwitz-Raum (1)
- Huwe1 (1)
- Hybridpolymer (1)
- Hydra <Polyp> (1)
- Hydrocortison (1)
- Hydroxylradikal (1)
- Hyperalgesie (1)
- Hypercortisolism (1)
- Hyperkalaemia (1)
- Hypertrophie (1)
- Hypertrophy (1)
- Hypervalentes Molekül (1)
- Hypopharyngeal glands (1)
- Hypophysen-Zwischenhirn-System (1)
- Hypothalamisch-hypophysäre Achse (1)
- Hämsotase (1)
- Höhengradient (1)
- Höherkoordinierte Verbdinungen (1)
- Hüft-TEP-Implantation (1)
- Hüftgelenksprothese (1)
- I-lactate (1)
- I-tasser (1)
- IABP (1)
- IC 310 (1)
- ICD (1)
- ICD-10 (1)
- ICF2 (1)
- ICL (1)
- ICSI (1)
- IGF-I (1)
- IGF1 (1)
- II citrullinemia (1)
- IL-1 α und β (1)
- IL28B polymorphisms (1)
- IMSI (1)
- ISS (1)
- ITAM (1)
- ITAM-signalling (1)
- ITS2 (1)
- IctP (1)
- Identität (1)
- Identitätswahrende Sitzverlegung von Gesellschaften (1)
- Ideology Erfahrung (1)
- Ighmbp2 (1)
- Il 4 (1)
- Ileuseinleitung (1)
- Image Processing (1)
- Imaging (1)
- Immunaktivierung (1)
- Immune activation (1)
- Immuninfiltration (1)
- Immunkardiomyopathie (1)
- Immunohistochemistry (1)
- Immunosuppression (1)
- Immunsystem (1)
- Immuntherapie (1)
- Impact-Faktor (1)
- Impedanzspektroskopie (1)
- Implantat (1)
- Implantatentwicklung (1)
- Implantatmatrices (1)
- Improved survival (1)
- In vitro (1)
- In vitro rat (1)
- In vivo Imaging (1)
- Incentive motivation (1)
- India (1)
- Indian National Congress (1)
- Indien (1)
- Indien <Parliament> (1)
- Induction of general anaesthesia (1)
- Infection imaging (1)
- Infektion (1)
- Infektionsbildgebung (1)
- Infektionsbiologie (1)
- Inflammatory pain (1)
- Inflation Targeting (1)
- Information Retrieval (1)
- Infrarotspektroskopie (1)
- Inhalation (1)
- Innenstadt (1)
- Innere Uhr (1)
- Insects (1)
- Instrumentalmusik (1)
- Insulin resistance (1)
- Intensivmedizin (1)
- Interferenzen (1)
- Interferon <Gamma-> (1)
- Interleukin-2 (1)
- Interleukin-5 (1)
- Internationales Gesellschaftsrecht (1)
- Intersektionalität (1)
- Intravital imaging (1)
- Introversion (1)
- Intubationszeit (1)
- Invasion (1)
- Inzidenz (1)
- Inzidenz <Medizin> (1)
- Iowa Gambling Task (1)
- Irak (1)
- Iran (1)
- Iraq (1)
- Irradiation (1)
- Ischämische Postkonditionierung (1)
- Isoform (1)
- Isomer (1)
- Jahresabschluss (1)
- Jahresbericht (1)
- Jordanien (1)
- Judit (1)
- Julius Hurwitz (1)
- KSR1 (1)
- Kaifeng (1)
- Kaiser Huizong (1)
- Kaiser test (1)
- Kalorimetrie (1)
- Kaloritronik (1)
- Kapitalmarktrecht (1)
- Kaposi sarcoma (1)
- Kardioprotektion (1)
- Kartellrecht (1)
- Kartellverbot (1)
- Kartierung (1)
- Kaskaden (1)
- Keck-Formel (1)
- Keck-Grundsätze (1)
- Keimbildung (1)
- Kenyon cells (1)
- Keratinozyt (1)
- Keratinozyten (1)
- Kernporen-Komplex (1)
- Ketonkörper (1)
- Kettenbruch (1)
- Kidney cancer (1)
- Kinase inhibitor (1)
- Kinasen (1)
- Kind (1)
- Kind <11-17 Jahre> (1)
- Kinder (1)
- Kinder im Vorschulbereich (1)
- Kinder- und Jugendpsychiatrie (1)
- Kindertagesstätte (1)
- Klassische Konditionierung (1)
- Kleidung (1)
- Klein- und Mittelbetrieb (1)
- Klima (1)
- Klimaschwankung (1)
- Klinik (1)
- Klinische Psychotherapie (1)
- Knochendichte (1)
- Knochenmark (1)
- Knochenmarktransplantation (1)
- Knock-Out (1)
- Knockout <Molekulargenetik> (1)
- Knockout mouse (1)
- Knockout-Maus (1)
- Knorpelzelle (1)
- Knotless tendon repair (1)
- Knowledge engineering (1)
- Kognitive Kontrolle (1)
- Kohlenmonoxid (1)
- Kohlenstoff-Kohlenstoff-Bindung (1)
- Kohlenstoff-Nanoröhre (1)
- Kohlenwasserstoffe (1)
- Kointegration (1)
- Kolonkarzinom (1)
- Komfortvokalisation (1)
- Kommunalverwaltung (1)
- Kommunikationsbeteiligung (1)
- Kommunikationssystem (1)
- Kommunikationsverhalten (1)
- Kompetenzbereich (1)
- Komplement (1)
- Komplexeinrichtung (1)
- Komplexitätsklasse (1)
- Komplexitätstheorie (1)
- Komplikation (1)
- Komplikationen dentaler Implantate (1)
- Komplimentärmedizin (1)
- Komprimierte Abtastung (1)
- Konditionierung (1)
- Kondo-Effekt (1)
- Kondo-Modell (1)
- Konflikt (1)
- Konfliktbewältigung (1)
- Konfokale Mikroskopie (1)
- Kongress (1)
- Konjugierte Polymere (1)
- Konrad <der Pfaffe> / Rolandslied (1)
- Konstruktive Didaktik (1)
- Kontingenz (1)
- Kontrastmittel (1)
- Kontrollierte klinische Studie (1)
- Konversationsanalyse (1)
- Konvoi (1)
- Konzerninsolvenzrecht (1)
- Koordinationspolymer (1)
- Koordinationspolymere (1)
- Kopf (1)
- Kopforthesentherapie (1)
- Koronarintervention (1)
- Koronarsyndrom (1)
- Korrelative Mikroskopie (1)
- Kortikale Regulation (1)
- Kosmische Strahlung (1)
- Kosten-Nutzen-Analyse (1)
- Koxarthrose (1)
- Kraniopharyngiom (1)
- Krebs (1)
- Krebserkrankung (1)
- Kreuzband (1)
- Kreuzung (1)
- Kreuzungsminimierung (1)
- Kreuzvalidierung (1)
- Krieg (1)
- Kristallfläche (1)
- Kristallisation (1)
- Kuh (1)
- Kunstgeschichte (1)
- Kurve (1)
- Kurzzeitphysik (1)
- Kutane Sarkome (1)
- Käfer (1)
- Körperstereotaktische Bestrahlung (1)
- L-3,4-Dihydroxyphenylalanine-induced dyskinesia (1)
- LAALO3/SRTIO3 interfaces (1)
- LARP4B (1)
- LAT2 (1)
- LC-MS/MS (1)
- LCK (1)
- LCST (1)
- LIN9 (1)
- LNCaP (1)
- LPS (1)
- LRP1 (1)
- LTT (1)
- Labial glands (1)
- Lactose (1)
- Ladungsträgergenerierung (1)
- Landkartenbeschriftung (1)
- Landnutzungsgradient (1)
- Landschaftsgarten (1)
- Landslide Susceptibility (1)
- Langlebigkeit (1)
- Langzeiteffektivität (1)
- Lanthanoide (1)
- Laparoskopische Cholecystektomie (1)
- Laplacian (1)
- Larvae (1)
- Larve (1)
- Laryngoskop (1)
- Laser Doppler vibrometer (1)
- Laserchemie (1)
- Laserspektroskopie (1)
- Late Positive Potential (1)
- Latrophilin receptor (1)
- Learning (1)
- Leaves (1)
- Lebenszyklus (1)
- Leber (1)
- Legionella pneumophila (1)
- Legumes (1)
- Lehrerhandreichung (1)
- Leishmania (1)
- Leishmaniose (1)
- Leitfähigkeit (1)
- Lenalidomid (1)
- Leptin (1)
- Leptoquark (1)
- Lernen (1)
- Lernort (1)
- Lernprogramm (1)
- Leseförderung (1)
- Lesetest (1)
- Leseverstehen (1)
- Leseverständnis (1)
- Leseverständnistest (1)
- Leuchtstoff (1)
- Leukapherese (1)
- Lichtstreuung (1)
- Lidocain (1)
- Ligand <Biochemie> (1)
- Liganden (1)
- Lineares System (1)
- Linguistische Methodik (1)
- Lipid-Carrier-Proteine (1)
- Lipidtransferprotein (1)
- Lippen (1)
- Liquor (1)
- Literatur (1)
- Literatur Review (1)
- Literature Review (1)
- Local Governance (1)
- Lok Sabha (1)
- Lokalisationsmikroskopie (1)
- Long-Memory-Prozesse (1)
- Long-term efficiency (1)
- Longitudinal analysis (1)
- Low-fat diet (1)
- Lumineszenz (1)
- Lung cancer (1)
- Lungenalveole (1)
- Lungenkrebs (1)
- Lymphozyten (1)
- Lymphozyten mediierter Angriff auf Neurone (1)
- Lymphozytentransformationstest (1)
- Lysine (1)
- Lysosomal storage disease (1)
- MAG3 (1)
- MAGIC-Teleskop (1)
- MALDI-MS (1)
- MAP Kinase Signaling (1)
- MAPK (1)
- MAPK signaling cascades (1)
- MCL-1 (1)
- MDS (1)
- MFM (1)
- MHC molecules (1)
- MIR-155 (1)
- MIZ1 (1)
- MMN (1)
- MODIS (1)
- MOF (1)
- MOPC315.BM (1)
- MRI criteria (1)
- MSOT (1)
- MVT (1)
- MYC (1)
- Macintosh-Laryngoskop (1)
- Macintosh-laryngoscope (1)
- Macrophage (1)
- Magenbypass (1)
- Magenchirurgie (1)
- Magnesiumphosphate (1)
- Magnesiumphosphatschäume (1)
- Magnetic Resonance Relaxometry (1)
- Magnetische Anisotropie (1)
- Magnetresonanz-Relaxometrie (1)
- Magnetresonanztomographie (1)
- Maiglöckchen (1)
- Maintenance treatment (1)
- Malabsorption (1)
- Malaria (1)
- Malaria tropica (1)
- Malassimilation (1)
- Malignant hyperthermia (1)
- Maligne Tumoren (1)
- Managed Floating (1)
- Mangankomplexe (1)
- Manganverbindungen (1)
- Mangelernährung (1)
- Mania (1)
- Marine sponge (1)
- Marktbürger (1)
- Markterwartungshypothese (1)
- Marokko (1)
- Maschinelles Sehen (1)
- Masern (1)
- Masernvirus (1)
- Mass spectrometry (1)
- Massenbewegung <Geomorphologie> (1)
- Massentrachten (1)
- Mastocytosis (1)
- Materielle Kultur (1)
- Mathematisches Modell (1)
- Matlab (1)
- Mausmodell (1)
- Mbm (1)
- MeDALL (1)
- Measurement invariance (1)
- Medienpädagogik (1)
- Mediterranean (1)
- Medizintechnik (1)
- Mehrkriterielle Optimierung (1)
- Meiose (1)
- Melanin (1)
- Melanoma (1)
- Melanomzelllinien (1)
- Meldepflichten (1)
- Melphalan (1)
- Membrandomänen (1)
- Meniskustransplantation (1)
- Mennonitendeutsch (1)
- Mensch (1)
- Merocyanine (1)
- Merocyaninfarbstoffe (1)
- Mesenchymal stem cells (1)
- Mesenchymale Stammzelle (1)
- Mesh (1)
- Mesocestoides vogae (1)
- Mesoporous (1)
- Messenger-RNS (1)
- Meta-Analyse (1)
- Metabolic Modelling (1)
- Metabolischen Modellierung (1)
- Metabolismus (1)
- Metal-only Lewis-Pairs (1)
- Metall-zentrierte Lewis-Paare (1)
- Metalloproteinasen (1)
- Metallorganische Verbindungen (1)
- Metallorganisches Netzwerk (1)
- Metastases (1)
- Metatranscriptomics (1)
- Methylene blue (1)
- Methylphenidat (1)
- Metomidat (1)
- Mevalonatmetabolimus (1)
- Mexican coffee plantations (1)
- Mexico (1)
- Mexiko (1)
- MicroRNA (1)
- Microarray (1)
- Microbial community (1)
- Microcavity devices (1)
- Migration (1)
- Mikrofertigung (1)
- Mikroresonator (1)
- Mikrosatellit (1)
- Mikrosatelliteninstabilität (1)
- Milchdrüse (1)
- Milz (1)
- Mineralokortikoidrezeptor (1)
- Mini Unmanned Aerial Vehicle (1)
- Minimal-invasive Chirurgie (1)
- Minipools (1)
- Mitbestimmung (1)
- Mitose (1)
- Mitotizität (1)
- Mittelhochdeutsch (1)
- Mittelmeerraum (1)
- Mittelstand (1)
- Miz1 (1)
- Mobile Sensor Network (1)
- Mobiles Internet (1)
- Model Based Reconstruction Algorithms in Magnetic Resonance Imaging (1)
- Modell (1)
- Modellbasierte-Rekonstruktionsalgorithmen in der Magnetresonanztomografie (1)
- Modellierung (1)
- Modifizierung (1)
- Molecular imaging (1)
- Molecular motion (1)
- Molekularbewegung (1)
- Molekulardesign (1)
- Molekulare Bildgebung (1)
- Molekulare Erkennung (1)
- Molekulargenetik (1)
- Molekularstrahl Epitaxie (1)
- Molekularstrahlepitaxie (1)
- Molekülphysik (1)
- Monadische Komposition (1)
- Monetit (1)
- Monitorüberwachung (1)
- Monoclonal Antibodies (1)
- Monodromie (1)
- Monodromy (1)
- Monopolar depression (1)
- Monoschicht (1)
- Monozyten (1)
- Monte-Carlo-Simulation (1)
- Morbus Alzheimer (1)
- Morbus Fabry (1)
- Morocco (1)
- Morphologie (1)
- Morris Water Maze (1)
- Motivation (1)
- Mountain permafrost (1)
- Mozart, Wolfgang Amadeus (1)
- Mucin (1)
- Mucorales (1)
- Multidimensionale Spektroskopie (1)
- Multidrug-Resistenz (1)
- Multiple Myeloma (1)
- Multiple Sclerosis (1)
- Multiple Sklerose (1)
- Multiport (1)
- Multivariate Zeitreihenmodelle (1)
- Multiwellenlängen (1)
- Murine models of thrombosis and haemostasis (1)
- Museumpädagogik (1)
- Mushroom bodies (1)
- Muskeldystrophie (1)
- Mustererkennung (1)
- Mutagenese (1)
- Mutationsraten (1)
- Mutter-Kind-Maßnahme (1)
- Mutterkindkur (1)
- Mutterkindvorsorge (1)
- Muttermilch (1)
- Myanmar (1)
- Myokardiales Remodeling (1)
- Myokardprotektion (1)
- N-Carboxyanhydride (1)
- N-Glykane (1)
- N-Myc (1)
- N-acetyllactosamine (1)
- N400 (1)
- NADPH-Oxidase (1)
- NCI H441 Zellen (1)
- NCI-H295 Zellen (1)
- NEIL2 (1)
- NF-kB (1)
- NFAT (1)
- NFATc1 (1)
- NFκB (1)
- NHC (1)
- NIRS (1)
- NK cells (1)
- NMO (1)
- NMR (1)
- NMR fingerprint (1)
- NMR-Tomographie (1)
- NRPS (1)
- NSAIDs (1)
- NTCDA (1)
- NVP-BEZ235 (1)
- NVP-BGT226 (1)
- Nah-Infrarot Reflexionsspektroskopie (1)
- Nahfeld Optik (1)
- Nahinfrarot-Spektroskopie (1)
- Nahrung (1)
- Nanoantenne (1)
- Nanodiamond (1)
- Nanog protein (1)
- Nanoimprint (1)
- Nanooptics (1)
- Nanooptik (1)
- Nanopartikel (1)
- Nanoporöser Stoff (1)
- Nanoprägen (1)
- Nanos (1)
- Nanostructures (1)
- Narkoseeinleitung (1)
- Narkosetechnik (1)
- Nase (1)
- Nash-Gleichgewicht (1)
- Natural Hazards (1)
- Neanderthal (1)
- Nebenniereninsuffizienz / adrenal insufficiency (1)
- Nebennierenkarzinom (1)
- Nebennierenkrise / adrenal crisis (1)
- Nebennierenrinde (1)
- Nebennierenrindeninsuffizienz (1)
- Nebennierenrindenkarzinom (1)
- Nebennierenrindenkrebs (1)
- Nectin4 (1)
- Nekrose (1)
- Neoblast (1)
- Nernst effect (1)
- Nervendegeneration (1)
- Nervensonographie (1)
- Nervenzelle (1)
- Nestbau (1)
- Netzwerkmanagement (1)
- Neues Steuerungsmodell (1)
- Neuroblast (1)
- Neuroblastom (1)
- Neuroligin 2 (1)
- Neurologische Komplikationen (1)
- Neuromyelitis optica (1)
- Neuronal ceroid lipofuscinosis (1)
- Neuronale Leitung (1)
- Neuronale Plastizität (1)
- Neuropeptide (1)
- Neuropeptide Hormone (1)
- Neuropeptidhormon (1)
- Neuroplasticity (1)
- Neurotizismus (1)
- Neurowissenschaften (1)
- Neutrino (1)
- Neutrino mass mixing (1)
- New Zealand (1)
- Newman strain sae (1)
- Nfatc1 (1)
- Nibelungenlied (1)
- Nicht-lokale Korrelationen (1)
- Nichtglatte Optimierung (1)
- Nichtionisierende Strahlung (1)
- Nichtlineare Spektroskopie (1)
- Nickelverbindungen (1)
- Nicotine (1)
- Nie Chongyi 聶崇義 (1)
- Niederlassungsfreiheit (1)
- Nierenfunktion (1)
- Niereninsuffizienz (1)
- Nierentransplantation (1)
- Nigeria (1)
- Nikaido-Isoda function (1)
- No-Bail-Out (1)
- Nogo-A (1)
- Non-invasive imaging (1)
- Non-steroidal anti-inflammatory drug (1)
- Nonlocal Correlations (1)
- North American (1)
- Northeastern Costa Rica (1)
- Northern Xinjiang (1)
- Notch Signalweg (1)
- Notch signalling (1)
- Notenbank (1)
- Novel PI3K (1)
- Novobiocin (1)
- Nuclear imaging (1)
- Nucleinbasen (1)
- Nukleosynthese (1)
- Numerische Physik (1)
- OCD (1)
- OCR (1)
- OCT (1)
- ODMR-Spektroskopie (1)
- OGG1 (1)
- Oberflächenfunktionalisierung (1)
- Oberflächenplasmonresonanz (1)
- Oberwelle (1)
- Obesity (1)
- Oct4 (1)
- Offenlegungspflichten (1)
- Okklusionsstörung (1)
- Omarthrose (1)
- Oncogene (1)
- Oncolytic Virotherapy (1)
- Onkogen (1)
- Onset (1)
- Oocytes (1)
- Oogenese (1)
- Oozyte (1)
- Oozyten (1)
- Opioid receptor (1)
- Opioidpeptide (1)
- Optical coherence tomography (1)
- Optimal control (1)
- Optimale Regelung (1)
- Optimalwertregelung (1)
- Optimierung (1)
- Optimization (1)
- Optische Fernerkundung (1)
- Optische Zeichenerkennung (1)
- Optischer Resonator (1)
- Orai1 (1)
- Organic Photovoltaics (1)
- Organic Semiconductors (1)
- Organic semiconductors (1)
- Organische Chemie (1)
- Organische Photovoltaik (1)
- Organische Synthese (1)
- Organisches Molekül (1)
- Organometallverbindungen (1)
- Osmoregulation (1)
- Osseointegartion (1)
- Osseointegration (1)
- Osteoporose (1)
- Out-of-school learning settings (1)
- Outcomes (1)
- Ovarialkarzinom (1)
- Oxidativer Stress (1)
- OxyR (1)
- Oxygen uptake (1)
- P-cresyl sulfate (1)
- P-gp inhibitors (1)
- P300 (1)
- P450scc (1)
- P50 (1)
- PARK2 (1)
- PCR analysis (1)
- PD-L1 (1)
- PDXP (1)
- PEG (1)
- PEG chemical modification (1)
- PEG-Anlage (1)
- PET/CT (1)
- PI3K (1)
- PI3K-Signalweg (1)
- PKS I (1)
- PKS II (1)
- PLP phosphatase (1)
- PMD (1)
- POLSCORE (1)
- PPD (1)
- PRC2 (1)
- PROLIFT (1)
- PSA (1)
- PSI-blast (1)
- PTCDA (1)
- PTCL (1)
- PZT (1)
- Palliativmedizin (1)
- Palliativmedizinische Tagesklinik (1)
- Palmitinsäure (1)
- Pamir (1)
- Pandemische Influenza A (1)
- Paraguay (1)
- Parallel Imaging (1)
- Parallele Bildgebung (1)
- Parametric optimization (1)
- Parametrische Optimierung (1)
- Parent-of-origin (1)
- Parkinson disease (1)
- Parlamentswahl (1)
- Particle Physics (1)
- Particle analytics (1)
- Partikelanalytik (1)
- Partizipatorische Demokratie (1)
- Partzipation (1)
- Passiv-Transfer (1)
- Pastorale (1)
- Patellarsehne (1)
- Patientenselektion (1)
- Pattern Mining (1)
- Pattern Recognition (1)
- Patulin (1)
- Pe (1)
- Pectoralis-Major-Lappen (1)
- Pediatric malignancy (1)
- Pentaerythrityltetranitrat (1)
- Pentakoordination (1)
- Peptide (1)
- Peptidtherapie (1)
- Peptoide (1)
- Performance Evaluation (1)
- Performance Management (1)
- Perfusion (1)
- Perinatal Asphyxia (1)
- Perineurium (1)
- Period2 (1)
- Periphere Analgesie (1)
- Persien (1)
- Persönlichkeit (1)
- Perylen (1)
- Perylenbisimid (1)
- Peyer's patches (1)
- Pharmakodynamik (1)
- Pharmakogenetik (1)
- Pharmakokinetik / pharmacokinetics (1)
- Pharynx (1)
- Phasenumwandlung (1)
- Phosphatasen (1)
- Phospho-Akt (1)
- Phospholamban (1)
- Phospholipase D (1)
- Phosphoproteine (1)
- Phosphorylierung (1)
- PhotoCORMs (1)
- Photoelektronenspektroskopie (1)
- Photoinduzierter Elektronentransfer (1)
- Photoionisation (1)
- Photonik (1)
- Photonische Kristalle (1)
- Photostrukturierung (1)
- Physical activity (1)
- Physik (1)
- Phytoplankton (1)
- Phänotyp (1)
- Pilocytic astrocytoma (1)
- Pilomyxoid astrocytoma (1)
- Pilomyxoides Astrozytom (1)
- Pilozytisches Astrozytom (1)
- Pioglitazon (1)
- Plagiocephalus (1)
- Plant-herbivore interactions (1)
- Plasmamembran (1)
- Plasmodium falciparum (1)
- Plasmon (1)
- Plasmon propagation (1)
- Plasmonics (1)
- Plastic electronics (1)
- Platelet count (1)
- Platinaddukte (1)
- Platinkomplex (1)
- Pneumothorax (1)
- PolSAR (1)
- Polarisierbarkeit (1)
- Polarity index (1)
- Politikwissenschaft (1)
- Pollination (1)
- Polylactide-co-glycolide (1)
- Polymer (1)
- Polymerase Kettenreaktion (1)
- Polymerase-Kettenrektion (1)
- Polymerisation (1)
- Polymers (1)
- Polymorphismen MMP-3 (1)
- Polypeptoid (1)
- Polypropylen-Netz (1)
- Polytrauma (1)
- Pomalidomid (1)
- Pooling (1)
- Popdc (1)
- Porsche (1)
- Port (1)
- Positioning (1)
- Posttranskriptionelle Regulation (1)
- Posttranslational modification (1)
- Posttranslationale Änderung (1)
- Potentialinduzierte Löschung (1)
- Predominant polarity (1)
- Probenecid (1)
- Probiotikum (1)
- Procurement (1)
- Profil (1)
- Profilierung (1)
- Profiling (1)
- Prognosis (1)
- Programmheft (1)
- Progressive Muskelentspannung (1)
- Progressive Relaxation (1)
- Prolaps (1)
- Proliferation (1)
- Proteaseinhibitor (1)
- Protected areas (1)
- Protein TRPC6 (1)
- Protein p53 (1)
- Protein-Protein-Wechselwirkung (1)
- Protein-Tyrosin-Kinasen (1)
- Proteindomänen (1)
- Proteindynamiken (1)
- Proteine (1)
- Proteintyrosinphosphatase (1)
- Proteomics (1)
- Proximaler Humerus (1)
- Präamplifizierung (1)
- Prädiktor (1)
- Prädiktoren (1)
- Präfrontaler Cortex (1)
- Präpositionen (1)
- Pseudo-allergy (1)
- Psoriasis (1)
- Psychologie (1)
- Psychopharmakologie (1)
- Psychophysiologie (1)
- Psychotherapie (1)
- Pulse shaping (1)
- Pulswellengeschwindigkeit (1)
- Pump-Probe-Spektroskopie (1)
- Punktion (1)
- Purcell-Effekt (1)
- Purchasing (1)
- PyMOL (1)
- Pyracylen (1)
- Pyridoxal 5'-phosphate phosphatase (1)
- Pyridoxalphosphat (1)
- Pyrrolidin (1)
- Pyrrolidinderivate (1)
- Q-CT (1)
- QKD (1)
- Quadrocopter (1)
- Quadrotor (1)
- Quality of Experience (1)
- Quality of life (1)
- Quality-of-Service (1)
- Qualität (1)
- Quantendynamik (1)
- Quantenkaskadenlaser (1)
- Quantenkommunikation (1)
- Quantenkontrolle (1)
- Quantentheorie (1)
- Quantifizierung (1)
- Quantum Foundations (1)
- Quantum dynamics (1)
- Quantum-well, -wire and -dot devices (1)
- Quasi-variational inequalities (1)
- Quecksilbertellurid (1)
- Querschnittsklausel (1)
- Questionnaire (1)
- Quetiapine (1)
- RAF1 (1)
- RAS (1)
- RCC (1)
- RDoC (1)
- RFID (1)
- RFP (1)
- RHO (1)
- RHO-associated kinease (1)
- RIM (1)
- RINEX Format (1)
- RNA (1)
- RNA CHAPERONE HFQ (1)
- RNA degradation (1)
- RNA sequence (1)
- RNA splicing (1)
- RNA-SEQ data (1)
- RNA-polymerase-I (1)
- RNA-polymerase-II (1)
- RNA-seq (1)
- RNAseq (1)
- RNS (1)
- RNS-Interferenz (1)
- ROK-alpha (1)
- ROS (1)
- RTMS (1)
- Rachitis (1)
- Radarsat-2 (1)
- Radioastronomie (1)
- Radiogalaxie (1)
- Radiologische Diagnostik (1)
- Radium (1)
- Raman spectroscopy (1)
- Rapid sequence induction (1)
- Raps (1)
- Rashba-Effekt (1)
- Rasterionenmikroskop (1)
- Rasterkraft-Mikroskopie (1)
- Rastertunnelmikroskop (1)
- Rauchen (1)
- Raumfahrt (1)
- Raumforderung (1)
- Reaktion (1)
- Reaktionskinetik (1)
- Reaktive Sauerstoffspezies (1)
- Reaktivität (1)
- Real-time PCR (1)
- Receptor kinase (1)
- Rechnernetz (1)
- Rechnungswesen (1)
- Recht (1)
- Rechtsprechung (1)
- Recombinant protein (1)
- Rectal cancer (1)
- Red Sea (1)
- Red sea (1)
- Redox-Stoffwechsel (1)
- Redoxpotential (1)
- Regional development (1)
- Regionale Wirtschaftsentwicklung (1)
- Regularisierung (1)
- Regularized gap function (1)
- Regulatorischer T-Lymphozyt (1)
- Regulatory Volume Decrease (1)
- Rehabilitation (1)
- Reifung (1)
- Reinfried von Braunschweig (1)
- Reizmuster (1)
- Rekombination (1)
- Rekonstruktion (1)
- Relaxation Parameter Mapping in Magnetic Resonance Imaging (1)
- Relaxationszeit (1)
- Remote sensing (1)
- Renal cell carcinoma (1)
- Renewable energies (1)
- Renin Angiotensin System (1)
- Renin-Angiotensin-System (1)
- Reperfusion (1)
- Reperfusions-induzierter Schaden (1)
- Repression <Genetik> (1)
- Reprogramming (1)
- Rescorla-Wagner model (1)
- Resensibilisierung (1)
- Resonatoren (1)
- Resonators (1)
- Resource and Performance Management (1)
- Ressourcenmanagement (1)
- Retail (1)
- Retest-reliability (1)
- Retinal degeneration (1)
- Reversal (1)
- Reward (1)
- Rezeption (1)
- Rhodobacter sphaeroides (1)
- Ribosom (1)
- Richardson-Olszewski-Syndrome (1)
- Riechstoff (1)
- Riesenmagnetowiderstand (1)
- Rind (1)
- Ringöffnungspolymerisation (1)
- Risikobegrenzungsgesetz (1)
- Risikoberatung (1)
- Risikofaktor (1)
- Risikofaktoren (1)
- Risikoverhalten (1)
- Riskanter Alkoholkonsum (1)
- Ritenklassiker (1)
- Ritus (1)
- Rituximab plus (1)
- Riutximab (1)
- Robotik (1)
- Rodung (1)
- Rotes Meer (1)
- Routing (1)
- Rupturen (1)
- Russian-German (1)
- Russisch-Deutsch (1)
- Russland (1)
- Rutschung (1)
- RyR1 mutations (1)
- Röntgen-Photoelektronenspektroskopie (1)
- Röntgenastronomie (1)
- Röntgenkristallographie (1)
- Röntgenmikroskop (1)
- Röntgenmikroskopie (1)
- Röntgenstrahlung (1)
- Rückmeldung (1)
- SAR (1)
- SERCA2a (1)
- SF-36 (1)
- SFE (1)
- SGLT-1 (1)
- SGLT2 inhibitor (1)
- SGN-35 (1)
- SGNH hydrolase (1)
- SH-6 (1)
- SH3-Domäne (1)
- SHFM (1)
- SHRSP (1)
- SLAM CDW150 (1)
- SLFN5 (1)
- SLX4 (1)
- SM-like protein (1)
- SMAD signaling (1)
- SMARD1 (1)
- SMN complex (1)
- SMN-Komplex (1)
- SNAP-Rezeptor (1)
- SNP array (1)
- SOCE (1)
- SPE (1)
- SPION (1)
- SPR-Spektroskopie (1)
- SPRED2 (1)
- SR proteins (1)
- SREBP (1)
- SREBP-2 (1)
- SREC-I (1)
- SRTIO3 (1)
- STAT3 (1)
- SUN1 (1)
- SWI2/SNF2-like protein (1)
- Salmonella enterica (1)
- Salmonella-containing vacuole (SCV) (1)
- Salzstress (1)
- Sanli tu 三禮圖 (1)
- Saproxylic beetles (1)
- Saproxylophage (1)
- Sarkom (1)
- ScFv (1)
- Scaffold fabrication (1)
- Scattering (1)
- Schaeffler (1)
- Schermischen (1)
- Schielen (1)
- Schieloperation (1)
- Schilddrüse (1)
- Schilddrüsenhormonmetabolismus (1)
- Schizophrenia (1)
- Schizophrenie (1)
- Schlaf (1)
- Schlafstörung (1)
- Schlaganfall (1)
- Schneeschmelze (1)
- Schold-Score (1)
- Scholl reaction (1)
- Scholl-Reaktion (1)
- Schreckreaktion (1)
- Schrei (1)
- Schulbuchforschung (1)
- Schuldenkrise (1)
- Schule (1)
- Schuppenflechte (1)
- Schutzgebiete (1)
- Schwangerschaft (1)
- Schwebfliegen (1)
- Schweineinfluenza (1)
- Schwere-Fermionen-System (1)
- Schwerverletzte (1)
- Schwerverletztenversorgung (1)
- Schwingungsspektroskopie (1)
- Schönheit (1)
- Scoring functions (1)
- Scoring-Funktionen (1)
- Scoringfunktionen (1)
- Sechsecknetz (1)
- Sedentary behaviour (1)
- Sedimentation (1)
- Seebeck effect (1)
- Sekundarstufe (1)
- Selbstorganisation (1)
- Selbstregulation (1)
- Selection of patients (1)
- Sella turcica (1)
- Semi- und nichtparametrische Methoden (1)
- Semiconductors physics (1)
- Semitendinosussehne (1)
- Sensory Gating (1)
- Septuaginta (1)
- Sequence motif analysis (1)
- Serotonin Transporter (1)
- Service Mobility (1)
- Set-valued mapping (1)
- Sex (1)
- Sex determination (1)
- Sexual development (1)
- Shift (1)
- Shiga toxin-producing Escherichia coli (1)
- Shopping-Center (1)
- Short-term-Variabilität (1)
- Sicherheitspolitik (1)
- Siciliano (1)
- Signal Noise (1)
- Signalpeptide (1)
- Signalwege (1)
- Sila-Substitution (1)
- Silber (1)
- Silicate (1)
- Silicium(II)-Komplexe (1)
- Silicium(IV)-Komplexe (1)
- Siliciumcarbid (1)
- Siliciumkomplexe (1)
- Siliciumorganische Verbindungen (1)
- Silicon(II) Complexes (1)
- Silicon(IV) Complexes (1)
- Silikon (1)
- Siloxane (1)
- Silylen (1)
- Simulation (1)
- Simulationstraining (1)
- Single Port Cholezystektomie (1)
- Single chain (1)
- Single-Port (1)
- Single-molecule (1)
- Singlet Fission (1)
- Sitting/standing (1)
- Sitzverlegung (1)
- Sjorgens-syndrome (1)
- Skin biopsy (1)
- Skint1 (1)
- Sleep disorders (1)
- Small nuclear RNP (1)
- Small-angle X-ray Scattering (1)
- Smoking (1)
- SnRK1 (1)
- Snap25 (1)
- Social Cognition (1)
- Societas Privata Europaea (1)
- Société fermée européenne (1)
- Software Engineering (1)
- Software Performance Engineering (1)
- Software Performance Modeling (1)
- Solar energy (1)
- Somatostatin receptor expression (1)
- Sonderpädagogik (1)
- Song Huizong <China, Kaiser> (1)
- Songdynastie <960-1279> (1)
- Sonnenblumen (1)
- Sourcing (1)
- South Africa (1)
- Sozial evaluative Situation (1)
- Sozialer Stil des Sprechens (1)
- SpecDis (1)
- Spectral Data Analysis (1)
- Spectroscopy (1)
- Speicherprofil (1)
- Spektrale Interferenz (1)
- Spektroelektrochemie (1)
- Spermatogenese (1)
- SphK1 (1)
- Spheciospongia vagabunda (1)
- Spieltheorie (1)
- Spin-Bahn-Wechselwirkung (1)
- Spin-Transfer-Drehmoment (1)
- Spinal dissemination (1)
- Spindle cell (1)
- Spindrehmoment Bauteil (1)
- Spinnenseide (1)
- Spintronic (1)
- Spinventil (1)
- Spirokohlenwasserstoffe (1)
- Spleißosom (1)
- Spontan Hypertensive Ratte (1)
- Sprache (1)
- Sprachlich-kommunikatives Verhalten (1)
- Sprachmischungen (1)
- Sprechen (1)
- Spred Protein (1)
- Spred-Proteine (1)
- Spumaviren (1)
- Squaraine (1)
- Squaraines (1)
- Src family (1)
- Stabilisierung (1)
- Stadtentwicklung (1)
- Stadtplanung (1)
- Stadtsoziolingusitik (1)
- Stadtsoziologie (1)
- Stanzbiopsie (1)
- Stark korrelierte Fermionen (1)
- Starke Kopplung (1)
- Stationenarbeit (1)
- Staupevirus (1)
- Stem cell (1)
- Sterblichkeit (1)
- Stereology (1)
- Stereotaxie (1)
- Stereotyp (1)
- Sterische Hinderung (1)
- Sternmesogene (1)
- Steuerbarkeit (1)
- Steuerbarkeit von Netzwerken (1)
- Stickstoffmonoxid (1)
- Stiff person syndrome (1)
- Stillen (1)
- Stoffeigenschaft (1)
- Stone-Wales rearrangement (1)
- Stone-Wales-Umlagerung (1)
- Strabismus divergens intermittens (1)
- Strahlenpilze (1)
- Strahlentherapie (1)
- Strahlung (1)
- Strahlungstransport (1)
- Stratafix (1)
- Stress (1)
- Stressreaktion (1)
- Stroke (1)
- Strukturierte Siliziumoberflächen (1)
- Strukturierung (1)
- Strukturoptimierung (1)
- Strukturtreue (1)
- Studie (1)
- Störgeräusch (1)
- Störungstheorie (1)
- Suberin (1)
- Subgroup Discovery (1)
- Subwavelength structures (1)
- Succinylcholine (1)
- Supernova (1)
- Supersymmetry (1)
- Supply Chain (1)
- Supply Chain Design (1)
- Supply Chain Management (1)
- Supply Management (1)
- Supply chain management (1)
- Support-Vektor-Maschine (1)
- Surface plasmons (1)
- Surgery (1)
- Sustainability (1)
- Swine (1)
- Symbiosis (1)
- Synapsine (1)
- Synaptinemal-Komplex (1)
- Synaptotagmin (1)
- Syntax (1)
- Synthesediamant (1)
- Syr Darya (1)
- Syrien (1)
- Systematic review (1)
- Systematischer (Literatur) Review (1)
- Szilvia Rad (1)
- Säugetiere (1)
- Südliche Songdynstie (1)
- Südostasien (1)
- T Cells (1)
- T Zellen (1)
- T cell (1)
- T cell cytotoxicity (1)
- T cell receptors (1)
- T cell rezeptor transfer (1)
- T cell silencing (1)
- T-DM1 (1)
- T-Lymphozyt info (1)
- T-Lymphozyten-Rezeptor (1)
- T-Zell-Rezeptor Transfer (1)
- T-Zelle (1)
- T-Zellrezeptor (1)
- T-antigens (1)
- T-cells (1)
- T-zelle (1)
- T1 quantification (1)
- T1-Quantifizierung (1)
- T6P (1)
- TAMT (1)
- TAVI (1)
- TDM (1)
- TEM (1)
- TERB1 (1)
- TGF (1)
- TH1 (1)
- TH2 (1)
- TLR4 (1)
- TME (1)
- TNF (1)
- TNF α (1)
- TNF-alpha (1)
- TOR (1)
- TP53 mutations (1)
- TRAIL mutants (1)
- TRAILR-Mutants (1)
- TRPM7 kinase (1)
- TYPE-2 (1)
- Tactile (1)
- Tagesklinik (1)
- Tagesrhythmus (1)
- Tagung (1)
- Tansania (1)
- Tanzania (1)
- Tapeworm (1)
- Taxonomie (1)
- Teamwork (1)
- Temozolomide (1)
- Temperaturbeständigkeit (1)
- Terahertzbereich (1)
- Terahertzstrahlung (1)
- Terminal 4q deletion syndrome (1)
- Termiten (1)
- Tertiärstudie (1)
- Tesseract (1)
- Testkonstruktion (1)
- Tetraarylpyracene (1)
- Tetrahydrodicyclopenta[fg,op]tetracen (1)
- Text Mining (1)
- Textilien (1)
- Theoretische Physik (1)
- Therapeutisches Drug Monitoring (1)
- Thermoelektrizität (1)
- Thermometrie (1)
- Thiolase (1)
- Thioredoxin (1)
- Thrombosis (1)
- Tian Shan (1)
- Tight Junction (1)
- Time-dependent Density Functional Theory (1)
- Tisuue Engineering (1)
- Todesrezeptoren (1)
- Toll like receptors (1)
- Toll-like-Rezeptoren (1)
- Topographic guidance (1)
- Topos (1)
- Total knee arthroplasty (1)
- Tourism (1)
- Tourismus (1)
- Trabekuläre Mesenchymale Stammzelle (1)
- Training (1)
- Trajectory tracking (1)
- Transforming Growth Factor beta (1)
- Transgenic mice (1)
- Transient Absorption (1)
- Transient layer (1)
- Transiente Absorption (1)
- Transkriptionsfaktor info (1)
- Transkriptomanalyse (1)
- Transmetallierung (1)
- Transparenzpflichten (1)
- Transplantationsimmunologie (1)
- Transporter SLC5A3 (1)
- Transporter SLC6A6 (1)
- Transposon (1)
- Travelling-salesman-Problem (1)
- Treg (1)
- Triarylamine (1)
- Tribolium castaneum (1)
- Tricarbonylverbindungen (1)
- Tuberkulose (1)
- Tumor microenvironment (1)
- Tumor-Nekrose-Faktor (1)
- Tumor-Nekrose-Faktor / Rekombinantes Protein (1)
- Tumorantigen (1)
- Tumorstoffwechsel (1)
- Tumortherapie (1)
- Tumorzelle (1)
- Tumour markers (1)
- Turbo Spin-Echos (1)
- Twisted gastrulation (1)
- Two-photon absorption (1)
- Two-photon polymerization (1)
- Typ-IV-Allergie (1)
- Tyrosinase (1)
- Tyrosinkinaseinhibitor (1)
- Türkei (1)
- Türkensattel (1)
- U-Bahnlinienplan (1)
- UBZ (1)
- UPEC (1)
- UV-VIS-Spektroskopie (1)
- Ubiquitin (1)
- Ultrafast Spectroscopy (1)
- Ultrafast information processing (1)
- Ultrafast measurements (1)
- Ultrafast spectroscopy (1)
- Ultrakurzer Lichtimpuls (1)
- Ultrakurzzeitlaser (1)
- Ultraschalldiagnostik (1)
- Ultraschnelle Photochemie (1)
- Ultrashort pulse lasers (1)
- Ultrathin Transmission Target (1)
- Ultraviolett-Bestrahlung (1)
- Umweltveränderung (1)
- Uncertainty (1)
- Unerwünschte Arzneimittelwirkung (1)
- Ungarn (1)
- Ungeheuer (1)
- Unionsbürgerschaft (1)
- United States (1)
- University students (1)
- Unmanned Aerial Vehicle (UAV) (1)
- Untergrundtemperaturen (1)
- Ununterscheidbarkeit (1)
- V-ATPasen (1)
- V-Loc (1)
- VEP (1)
- VKORC1 (1)
- VMH (1)
- VOC emissions (1)
- Vaccinia Virus (1)
- Vaccinia virus (1)
- Vaccinia-Virus (1)
- Vacuum stability (1)
- Valenz <Linguistik> (1)
- Valeriana wallichii (1)
- Varianzanalyse (1)
- Variation (1)
- Vascularisation (1)
- Vascularization (1)
- Vaskularisation (1)
- Vaskularisierung (1)
- Vaskulitische Polyneuropathie (1)
- Venlafaxin (1)
- Verbraucherschutzrecht (1)
- Verhalten (1)
- Verhaltenskontrolle (1)
- Verteiltes System (1)
- Vesicles (1)
- Vestibularisschwannom (1)
- Viabilität (1)
- Video Quality Monitoring (1)
- Vienna Forest (1)
- Virtual-reality (1)
- Virtuelle Realität (1)
- Virtuelles Netzwerk (1)
- Virulenz (1)
- Virulenzfaktor (1)
- Virus (1)
- Vision Based (1)
- Visual Tracking (1)
- Visus (1)
- Visus-VEP (1)
- Vitamin K epoxide reductase (1)
- Volkswagen (1)
- Volumenregulation (1)
- Volumentomographie (1)
- Volumenänderungen (1)
- Vor- und Frühgeschichte (1)
- Vorläuferzelle (1)
- Vorläuferzellen (1)
- Voronoi tree map (1)
- Vulgata (1)
- Vulnerable plaque (1)
- Vγ9Vδ2 T cell (1)
- Vγ9Vδ2 T cells (1)
- W355 (1)
- W359 (1)
- WNT pathway (1)
- Wahlen in Indien (1)
- Wahrscheinlichkeitstheorie (1)
- Wald (1)
- Warfarin (1)
- Warning (1)
- Warnung (1)
- Warnungen (1)
- Warsaw breakage syndrome (1)
- WebLogo (1)
- Wechselkurspolitik (1)
- Weiterführende Schulen (1)
- Weltbild Mittelalter (1)
- Werbesprache (1)
- Werk (1)
- Werkstoffeigenschaft (1)
- Wettbewerbsrecht (1)
- Wheelchair (1)
- Wien (1)
- Wiener Klassik (1)
- Wienerwald (1)
- Wirkmechanismus (1)
- Wirkstoff (1)
- Wirkstofffreisetzung (1)
- Wirkstoffspeichersystem (1)
- Wirtschaftsförderung (1)
- Wirtszelle (1)
- Wissenschaftliches Arbeiten (1)
- Wissensextraktion (1)
- Wissenstechnik (1)
- Wnt-Proteine (1)
- Wolfram <von Eschenbach> (1)
- Wortstellung (1)
- Wundheilung (1)
- Wurzel (1)
- X-rays (1)
- Xenopus oocytes (1)
- Y chromosome (1)
- Yaşar Kemal (1)
- YoelII-Nigeriensis (1)
- ZBTB24 (1)
- ZBTB24 mutations (1)
- ZW sex chromosomes (1)
- Zeitabhängige Dichtefunktionaltheorie (1)
- Zeitauflösung (1)
- Zeitreihenanalyse (1)
- Zeitschrift (1)
- Zellassay (1)
- Zelle (1)
- Zellkontakt (1)
- Zellkulturmodell (1)
- Zellmarker (1)
- Zellmarkierung (1)
- Zellmigration (1)
- Zellskelett (1)
- Zellteilung (1)
- Zellvolumen (1)
- Zellüberleben (1)
- Zentralnervensystem (1)
- Zeolith (1)
- Zerebraler Insulinmetabolismus (1)
- Zielgesellschaft (1)
- Zinkchlorin (1)
- Zinn (1)
- Zins (1)
- Zirkulardichroismus (1)
- Zucker (1)
- Zufriedenheit mit PEG (1)
- Zufriedenheitsanalyse (1)
- Zugspitze (1)
- Zutokin (1)
- Zwei-Photonen-Polymerisation (1)
- Zwei-Poren Domänen Kaliumkanäle (1)
- Zweiphotonenabsorption (1)
- Zweisprachigkeit (1)
- Zyklopeptid (1)
- Zytokine (1)
- [18F]Fluorodeoxythymidine (1)
- abdominal aortic-aneurysm (1)
- aberration (1)
- abietane (1)
- abnormalities (1)
- abscisic acid (1)
- abundance (1)
- accessibility (1)
- accumulation (1)
- acetyltransferase RTT109 (1)
- acid dissociation (1)
- acoustic signals (1)
- acrican trypanosomes (1)
- acromiopectoral flap (1)
- actin (1)
- actin filament (1)
- actinomycetes (1)
- actinosporins (1)
- action (1)
- action ability (1)
- action access (1)
- action and perception (1)
- action effects (1)
- action videogaming (1)
- activated receptor-1 (1)
- activating receptors (1)
- active middle-ear implant (1)
- active zone (1)
- activity rhythm (1)
- acupuncture (1)
- acute kidney injury (1)
- acute lymphoblastic leukemia (1)
- acute mania (1)
- acute myelogenous leukemia (1)
- acute myeloid-leukemia (1)
- acute watery diarrhea (1)
- adaptation (1)
- adaptive plasticity (1)
- adaptor protein Swiprosin-1/EFhd2 (1)
- add-on (1)
- additionsvernetzende Silikone (1)
- adduct (1)
- adenocarcinoma of the lung (1)
- adenosine (1)
- adenylyl cyclase (1)
- adenylyl-cyclase isoforms (1)
- adhesion dynamics (1)
- adhesion molecules (1)
- adipose tissue (1)
- adipose tissue engineering (1)
- adolescent (1)
- adoptive transfer (1)
- adrenal glands (1)
- adrenal medulla (1)
- adrenale Steroidogenese (1)
- adrenokortikale Zellen (1)
- adult attention deficit hyperactivity disorder (aADHD) (1)
- adult cardiac myocytes (1)
- advanced therapy medicinal products (1)
- affective state (1)
- afferents (1)
- affinity (1)
- african trypanosomes (1)
- age (1)
- age groups (1)
- age polyethism (1)
- agriculture (1)
- agroecosystems (1)
- albinaria (1)
- albuminuria (1)
- aldosterone (1)
- algorithm (1)
- alignment (1)
- alignment clustering (1)
- all-cause mortality (1)
- allergic rhinitis (1)
- allergy (1)
- allogeneic hematopoietic stem cell transplantation (1)
- allorecognition (1)
- alpaca (1)
- alpha-emitters (1)
- alpha-helical structure (1)
- alpha/delta agonist GFT505 (1)
- ambystoma opacum (1)
- amino acids (1)
- amino groups (1)
- amino-acid-metabolism (1)
- aminocoumarins (1)
- aminopeptidase N (1)
- ampa receptors (1)
- amphibia (1)
- amphibian metamorphosis (1)
- amphiphilic poly(2-oxazoline)s (1)
- amphiphysin (1)
- amplifications (1)
- amygdala (1)
- amyloidosis (1)
- amyotrophic lateral sclerosis (1)
- anaesthetics (1)
- analgesia (1)
- anaplastic large cell lymphoma (ALCL) (1)
- angle resolved photo emission spectroscopy (1)
- angle-resolved photoemission spectroscopy (1)
- anguage and word processing (1)
- anhedonia (1)
- animal behavior (1)
- animal model (1)
- animal models (1)
- ankles (1)
- annecin-V (1)
- annotation (1)
- annual report (1)
- anorexia nervosa (1)
- anspruchsvolle Hörsituation (1)
- ant (1)
- anteriorer Zugang (1)
- anthocyanin derivatives (1)
- anti-CD30 drug conjugate (1)
- anti-infectives (1)
- anti-trypanosoma (1)
- antibiotic (1)
- antibody (1)
- anticipation (1)
- antifungal agents (1)
- antifungals (1)
- antigenetic variation (1)
- antigens (1)
- antiretroviral therapy (1)
- antisense RNA (1)
- antisense RNAs (1)
- antitumor immunity (1)
- anxiety disorders (1)
- apical GLUT2 (1)
- applied physics (1)
- approximation (1)
- april (1)
- arbuscular mycorrhizal fungi (1)
- arctic (1)
- argeted therapy (1)
- arginine (1)
- arlR (1)
- arousal (1)
- arteriovenous loop (1)
- arthropods (1)
- artifact (1)
- aspergillosis (1)
- assay (1)
- association (1)
- astrocytes (1)
- astroparticle (1)
- asymmetric dark matter (1)
- atherogenic dyslipidaemia (1)
- atherosclerotic vascular disease (1)
- atomar kleine Lücke (1)
- atomic-scale gap (1)
- atrophy Kennedys-disease (1)
- attachment glycoprotein (1)
- attention (1)
- attention capture (1)
- attentional bias (1)
- attentional impulsivity (1)
- audiovisual integration (1)
- audiovisual interactions (1)
- audit fees (1)
- audit fees enforcement interim reporting (1)
- auditory brainstem implant (1)
- auditory cortex (1)
- auditory effort (1)
- auditory stimuli (1)
- aurora kinase A polymorphism (1)
- aurorakinase B (1)
- authoring environment (1)
- autism (1)
- autoantibodies (1)
- autoantigen (1)
- autograft (1)
- autoimmunity (1)
- autologous transplantation (1)
- autologous tumor (1)
- autonomes Nervensystem (1)
- autonomic nervous system (1)
- autophagy-related (1)
- autosomal-dominant osteopetrosis (1)
- auxin (1)
- axon regeneration (1)
- axonal integrity (1)
- axonal transport (1)
- axons (1)
- azacitidine (1)
- azines / diazines (1)
- bZIP (1)
- bZIP transcription fators (1)
- bacillus subtilis (1)
- background odor (1)
- bacterial genomes (1)
- bacterial infection (1)
- bacterial pathogens (1)
- banding analyses (1)
- bariatrische Eingriffe (1)
- baryon asymmetry (1)
- bcl-2 associated athanogene protein 3 (1)
- bee pollinators (1)
- behavior (1)
- behavioral activation system (1)
- behavioral conditioning (1)
- benzalkonium chloride (1)
- benzimidazole (1)
- beta (1)
- beta-cyclodextrin (1)
- beta-oxidation (1)
- beta-tubulin (1)
- beta1-adrenergic receptor (1)
- bevacizumab (1)
- bibliometrics (1)
- bibliométrie (1)
- bilingualism (1)
- bimaxillär (1)
- binding protein (1)
- binding proteins (1)
- binge eating (1)
- biochemical characterization (1)
- biodiversity conservation (1)
- biodiversity index (1)
- biodiversity measure (1)
- bioelectrochemistry (1)
- biogenesis (1)
- bioinformatic (1)
- bioinformatics (1)
- bioisosterism (1)
- biology (1)
- biomarkers UPA (1)
- biominarlization proteins (1)
- biophosphonate (1)
- biosynthetic gene-cluster (1)
- bipolar disorders (1)
- bird species richness (1)
- birth rates (1)
- bispidine (1)
- blend (1)
- blood plasma (1)
- blood-stream forms (1)
- blood–brain barrier choline transporter (1)
- body fat (1)
- bond activation (1)
- bone (1)
- bone loss (1)
- bone marrow transplantation (1)
- bone metastasis (1)
- bone-marrow (1)
- bone-mineral density (1)
- bone-targeting radiopharmaceuticals (1)
- bortezomib plus dxamethasone (1)
- borylene (1)
- botanical gardens (1)
- bourgeonal (1)
- bradykinin (1)
- brain computer interface (1)
- brain images (1)
- brain potentials (1)
- brain-computer interfaces (1)
- breakpoint (1)
- breast-cancer cells (1)
- breastfeeding (1)
- bronchial tissue (1)
- brush border membrane (1)
- bryozoan bugula-neritina (1)
- bulky ligands (1)
- bumblebee nest density (1)
- butterfly euphydryas-aurinia (1)
- börsennotierte Gesellschaft (1)
- c-myc (1)
- cAMP (1)
- cGMP (1)
- caffeic acid bornyl ester (1)
- caffein (1)
- calcium (1)
- calcium absorption (1)
- calcium dependent membrane conductance (1)
- calcium homeostasis (1)
- calcium phosphate (1)
- calcium-activated potassium channel (1)
- calcium-phosphate (1)
- calciumabhängige Membranleitfähigkeiten (1)
- cameras (1)
- camponotus aethiops (1)
- campylobacteriosis (1)
- canagliflozin (1)
- cancer cell (1)
- cancer stem cell immunology (1)
- cancer stem cells (1)
- canine (1)
- canine and feline cancer therapy (1)
- capacitance (1)
- capsaicin (1)
- carbohydrate (1)
- carbohydrate chemistry (1)
- carbon metabolism (1)
- carbon monoxide (1)
- carbon nanomaterials (1)
- carcinogen activation (1)
- carcinoma (1)
- cardiac MRI (1)
- cardiac perception (1)
- cardiac surgery (1)
- cardiology (1)
- cardiomyocyte proliferation (1)
- cardiopulmonary exercise testing (1)
- cardiovascular disease (1)
- cardiovascular munster procam (1)
- cardiovascular pharmacology (1)
- cardiovascular risk (1)
- carnivorus plants (1)
- carousel maze (1)
- carriage (1)
- carrier density (1)
- cat (1)
- catechins (1)
- cathepsin (1)
- cathepsin-L (1)
- cations (1)
- celeco - Richtig Lesen Lernen (1)
- cell binding (1)
- cell biology (1)
- cell death (1)
- cell growth (1)
- cell membrane (1)
- cell membranes (1)
- cell penetrating peptides (1)
- cell-adhesion (1)
- cell-cycle arrest cancer therapy (1)
- cellular internalization (1)
- cellular receptor (1)
- cellular therapy (1)
- cement (1)
- central carbon metabolism (1)
- central core disease (1)
- central metabolism (1)
- centromeric instability (1)
- cerebEND (1)
- cereblon expression (1)
- cerebral arteries (1)
- cerebral artery occlusion (1)
- cerebrovascular diseases (1)
- ceriops decandra (1)
- cetuximab (1)
- chaperone Hfq (1)
- charge-coupled device (1)
- chemical diversity (1)
- chemische Modifizierung (1)
- chemotherapy resistance (1)
- chi square tests (1)
- chila catalysis (1)
- chirale Kathalyse (1)
- chlamydia trachomatis (1)
- chlamydomonas flagella (1)
- cholesterol (1)
- cholesterol depletion (1)
- cholinergic interneurons (1)
- chondrocytes (1)
- chromatin (1)
- chromatin assembly factors (1)
- chromosomal aberration (1)
- chromosome evolution (1)
- chronic Hepatitis C (1)
- chronic cerebrovascular disease (1)
- chronic heart failure (1)
- chronic kidney-disease (1)
- chronic myelogenous leukemia (1)
- chronic myeloid leukemia (1)
- chronic phase (1)
- chronic thromboembolic pulmonary hypertension (1)
- ciliary neurotrophic factor (1)
- circadian oscillators (1)
- circadian rhythmicity (1)
- circadian rhythms (1)
- circular dichroism (1)
- circular dichroism spectra (1)
- circular-dichroism (1)
- circulation patterns (1)
- class (1)
- class-I (1)
- classical conditioning (1)
- classification (1)
- claudin-1 (1)
- clausiliidae (1)
- clearance (1)
- cleavage (1)
- climate change (1)
- clinical (1)
- clinical practice guidelines (1)
- clinical study (1)
- clinically isolated syndromes (1)
- clock genes (1)
- cloud (1)
- clumping factor-B (1)
- co-cultivation (1)
- co-evolution (1)
- co-gels (1)
- coagulation (1)
- coagulation factor XII (1)
- coatings (1)
- cochlea (1)
- cochlear implant (1)
- cognitive decline (1)
- cognitive-behavioral therapy (1)
- cognitive-behavioural psychotherapy (1)
- cohesin SMC1-Beta (1)
- cohort studies (1)
- cold stress (1)
- colestilan (1)
- collagens (1)
- colon (1)
- colonies (1)
- colonization (1)
- colony (1)
- colorectal cancer (1)
- columnar architecture (1)
- coma (1)
- comb (1)
- combined immunodeficiency (1)
- combined therapy (1)
- commercial grades (1)
- common genetic determinants (1)
- common variants (1)
- community structures (1)
- comparative molecular field analysis (1)
- comparative molecular similarity index analysis (1)
- complement (1)
- complex-III (1)
- complexation (1)
- component (1)
- components (1)
- compound eye (1)
- computer software (1)
- concept maps (1)
- conceptual change (1)
- condensed matter physics (1)
- condensed-matter physics (1)
- conditioned response (1)
- conifers (1)
- conjugated mycotoxins (1)
- connective tissue (1)
- conservation (1)
- conservation laws (1)
- consortium (1)
- constraints (1)
- contact-kinin system (1)
- contextual conditioning (1)
- contextual fear (1)
- contingency awareness (1)
- continous fields (1)
- contrast-enhanced ultrasound (1)
- convergent extension movements (1)
- conversational analysis (1)
- coordination polymer (1)
- coping (1)
- copy-number alteration (1)
- coronary artery disease (1)
- coronary heart disease (1)
- corpus cavernosum (1)
- correlated electrons (1)
- correlated systems (1)
- correlates (1)
- cortisol (1)
- cosmic ray (1)
- cosmic rays (1)
- cotransporter (1)
- cotton rats (1)
- coulomb coupled quantum dots (1)
- craving (1)
- crop identification (1)
- crop mapping (1)
- crop monitoring (1)
- crop yield (1)
- crops (1)
- crossing minimization (1)
- crossover trial (1)
- crystal-structures (1)
- cues (1)
- cul3 ring ligase (1)
- cultivation (1)
- cultured fibroplasts (1)
- curves (1)
- cutaneous patch (1)
- cycle regulation (1)
- cyclic AMP (1)
- cyclic-AMP (1)
- cyclin-dependent kinases (1)
- cycloaddition (1)
- cyclodextrin (1)
- cyclophsophamide (1)
- cysteine protease (1)
- cystic fibrosis (1)
- cytochrome P450 3A4 (1)
- cytogenetic response (1)
- cytokine (1)
- cytokine responses (1)
- cytokinesis (1)
- cytokinin (1)
- cytokinins (1)
- cytolethal distending toxin (1)
- cytosol (1)
- cytotoxicity receptors (1)
- damage (1)
- damascone (1)
- dark matterWIMP (1)
- dark-matter (1)
- data fusion (1)
- data sharing (1)
- data-bank (1)
- database (1)
- de-novo methylation (1)
- deafness (1)
- death receptors (1)
- decandrinin (1)
- decision making (1)
- declines (1)
- decompensating exophoria (1)
- deep bisulfite sequencing (1)
- deep brain-stimulation (1)
- deer cervus-eldi (1)
- defensive reactivity (1)
- deficient mice (1)
- definition (1)
- deformation (1)
- degradation (1)
- dekompensierende Exophorie (1)
- delay conditioning (1)
- deletions (1)
- demanding hearing situations (1)
- demography (1)
- demyelinating disease (1)
- demyelinating polyradiculoneuropathy (1)
- dendrimer conjugates (1)
- dendritic cells (1)
- dendritic cell (1)
- denritic cells (1)
- density (1)
- density-functional theory (1)
- dentichasmias busseolae (1)
- dependent gene-expression (1)
- deposition (1)
- deprivation (1)
- detection (1)
- determinant (1)
- developing country (1)
- developing oilseeds (1)
- development (1)
- developmental biology (1)
- developmental plasticity (1)
- developmental reprogramming (1)
- dexamethasone (1)
- diabetes (1)
- diabetes mellitus (1)
- dialysate (1)
- dialysepflichtige Niereninsuffizienz (1)
- dialysis (1)
- dialyzer membrane (1)
- diazepam (1)
- dielectric oxides (1)
- different imatinib dose regimens (1)
- differentation (1)
- differential (1)
- differential age distribution (1)
- diffusion (1)
- diffusive component (1)
- digestive system (1)
- digitale Netze (1)
- digitization (1)
- dilation (1)
- dionaea muscipula (1)
- dirac fermions (1)
- direct PCR (1)
- directional RNA-Seq (1)
- disc deseases (1)
- discrimination (1)
- disease-associated (1)
- diseases (1)
- disorder (1)
- distal fixation (1)
- distinct (1)
- divided attention (1)
- documents (1)
- domain (1)
- domains (1)
- dominant optic atrophy (1)
- dopa-induced dyskinesia (1)
- dopamine acetylcholine (1)
- doule blind (1)
- doxorubicin (1)
- dreidimensional (1)
- dreidimensionale Rekonstruktion (1)
- drug (1)
- drug delivery vector (1)
- drug discovery (1)
- drug therapy (1)
- drug-addiction (1)
- drug-drug interactions (1)
- dual-task control (1)
- dung beetle coleoptera (1)
- dye stains-all (1)
- dynamic programming (1)
- dynamical mean field theory (1)
- dynamics (1)
- dyspnea (1)
- dystrophic RCS rats (1)
- e1071 (1)
- eExons (1)
- early applied higher imatinib dosages (1)
- early intervention (1)
- early recognition (1)
- early respiratory-failure (1)
- early response (1)
- early-life (1)
- earnings management (1)
- economic growth (1)
- economy services (1)
- ecosystem service (1)
- ecosystem services (1)
- ecosystemservices (1)
- edema (1)
- education (1)
- educational attainment (1)
- eigenvector centrality (1)
- ejection fraction (1)
- elderly patients (1)
- elderly persons (1)
- electrical excitation (1)
- electrically driven (1)
- electroacupuncture (1)
- electrocorticography (1)
- electroencephalogram (1)
- electroencephalography (1)
- electron density (1)
- electron tunneling (1)
- electronic-structure calculations (1)
- electroporation (1)
- electroweak phase transition (1)
- elektrische Anregung (1)
- elektronische Trainingssysteme (1)
- element (1)
- elevational gradient (1)
- embryo (1)
- embryonic stem cell (1)
- embryos (1)
- emotion (1)
- emotional information (1)
- emotional pictures (1)
- emotional scene stimuli (1)
- emotional sounds (1)
- empagliflozin (1)
- enantioselective (1)
- enantioselektiv (1)
- endocannabinoid release (1)
- endochondral ossification (1)
- endonuclease (1)
- endoplasmatic reticulum (1)
- endothelial cell (1)
- endothelial cells (1)
- endothelial growth factor (1)
- endothelial injury (1)
- endothelial progenitor cells (1)
- endotoxemia (1)
- energies (1)
- energy (1)
- energy bands (1)
- energy signaling (1)
- enforcement (1)
- engagement (1)
- engaging aantibody (1)
- enhance (1)
- enteric nervous system (1)
- enterobacteria (1)
- enteropathy (1)
- envelope (1)
- environment (1)
- environmental cues (1)
- enzyme-linkes immunoassays (1)
- enzymes (1)
- epidemology (1)
- epidural anesthesia (1)
- epidural recording (1)
- epigenetic heterogeneity (1)
- epistemic modality (1)
- epitheliae Barriere (1)
- error monitoring (1)
- erythropoietin (1)
- essential genes (1)
- european birth cohorts (1)
- evaluation (1)
- event related potentials (1)
- event-related FMRI (1)
- evidentiality (1)
- evolutionary mutant model (1)
- exercise (1)
- exome sequencing (1)
- expenditure (1)
- experience sampling (1)
- experimental autoimmune neuritis (1)
- expertise (1)
- expression site attenuation (1)
- extinction (1)
- extinction risk (1)
- extracellular matrix (1)
- eyes (1)
- face (1)
- facial anomalies (1)
- facial expression (1)
- facial expressions (1)
- facial pain (1)
- factor XI (1)
- factor acetylhydrolase activity (1)
- factor-V-Leiden (1)
- fanconi anemia (1)
- fanconi-anemia (1)
- fatty acids (1)
- fatty liver disease (1)
- fear conditioning (1)
- fear potentiated startle response (1)
- feasibility (1)
- femtochemistry (1)
- femtosecond spectroscopy (1)
- fenoterol (1)
- fermions (1)
- ferrocene (1)
- fetal preconditioning (1)
- fibers (1)
- fibrin D-dimer (1)
- fibromyalgia (1)
- filtering (1)
- finder using symmetrical best hits (1)
- fire (1)
- fish (1)
- fission yeast (1)
- flagellar basal body (1)
- flagellum (1)
- flavour symmetry (1)
- flesh (1)
- floating mass transducer (1)
- flowers (1)
- fluorescence in-situ hybridization (1)
- fluorescence microscopy (1)
- fluorescence quenching (1)
- fluorescence resonance energy transfer (1)
- fluorescent protein (1)
- fluoreszenz (1)
- fluticasone propionate (1)
- flux balance analysis (1)
- focal adhesions (1)
- folinic acid (1)
- follow up (1)
- food addiction (1)
- food carving (1)
- food consumption (1)
- food craving (1)
- food pictures (1)
- food-gene interactions (1)
- foraging behavior (1)
- force (1)
- forecasting (1)
- forests (1)
- formica cunicularia (1)
- fragmented landscapes (1)
- framing (1)
- free energy of solvation (1)
- free space (1)
- free survival (1)
- fremdkörper assoziierte Reaktion (1)
- frequencies (1)
- frogs (1)
- fructose (1)
- fruit set (1)
- fruit-quality (1)
- full thickness skin (1)
- fumarate (1)
- functional architecture (1)
- fungal diseases (1)
- fungal pathogens (1)
- fusiform gyrus (1)
- galaxolide (1)
- galbanone (1)
- galectin-1 (1)
- gambling (1)
- gamete (1)
- gamma ray (1)
- gamma rays (1)
- gamma-cyclodextrin (1)
- gamma-ray burst (1)
- gastrointestinal mucositis (1)
- geckos (1)
- gekoppelte Kavitäten (1)
- gels (1)
- gemcitabine (1)
- geminale Rekombination (1)
- gemischte Leukozytenkultur (1)
- gender (1)
- gene polymorphism (1)
- gene therapy (1)
- gene-expression (1)
- gene-expression data (1)
- generalization (1)
- generation (1)
- genes and chromosomes (1)
- genetic deletion (1)
- genetic interference (1)
- genetic modifiers (1)
- genetic variability (1)
- genetics (1)
- genetische Beratung (1)
- genome analysis (1)
- genome-wide association (1)
- genomes (1)
- genomic aberrations (1)
- genomic databases (1)
- genomic response (1)
- genomic stability (1)
- genotoxicity (1)
- geometric mean (1)
- germinative cells (1)
- gesolin function (1)
- gestational age (1)
- gestielte Lappen (1)
- glaucoma (1)
- glaucoma surgery (1)
- global change (1)
- global health (1)
- glucocorticoid receptor (1)
- glucose (1)
- glucose tolerance test (1)
- glutamate decarboxylase 65 (1)
- glutamate dehydrogenase (1)
- glycemic control (1)
- glycogen phosphorylase (1)
- glycogen synthase (1)
- glycoproteins (1)
- glycosome (1)
- go/no-go task (1)
- grade 3B (1)
- grammar (1)
- granulomas (1)
- graph drawing (1)
- grasland (1)
- grasslands (1)
- grb (1)
- group B genotype (1)
- group-A (1)
- growth hormone deficiency (1)
- guanylyl cylcase A (1)
- gut bacteria (1)
- gyrase (1)
- habitat destruction (1)
- habitat patch (1)
- habitat preferences (1)
- habitat quality (1)
- habitats (1)
- haemophilus influenzae (1)
- haemoproteus-columbae (1)
- halichondria panicea (1)
- hand/foot malformation (1)
- hands (1)
- haploidentical γδ T lymphocytes (1)
- haplotypanalysis (1)
- haplotype (1)
- harmonization (1)
- hashimotos-thyroiditis (1)
- head (1)
- head injury (1)
- health (1)
- healthy children (1)
- hearing impairment (1)
- heart rate variability (1)
- heart-failure (1)
- heat conversion (1)
- heat shock response (1)
- heavy fermions (1)
- hela cells (1)
- helitron (1)
- helminth infection (1)
- helper T-cells (1)
- hematologic malignancies (1)
- hematopoietic cell transplantation (1)
- hemodialysis (1)
- hemolytic-uremic syndrome (1)
- heptacellular carcinoma (1)
- herbivores (1)
- hernia (1)
- hernia repair (1)
- heroine (1)
- herpesvirus (1)
- heterodinuclear compound (1)
- heteromolecular interfaces (1)
- heteropathogenicity (1)
- heterotrophic arabidopsis cells (1)
- hexose transporter (1)
- hidden markov-models (1)
- hidden mycotoxins (1)
- hidden-beauty states (1)
- hidden-order (1)
- high calorie (1)
- high denisty lipoprotein (1)
- high numbers (1)
- high-bone-mass (1)
- high-dose chemotherapy (1)
- hippocampal neurons (1)
- histology (1)
- hive (1)
- homeodomain transcription factors (1)
- homologous chromosomes (1)
- homologs (1)
- homology modeling (1)
- homology search (1)
- honey (1)
- honey bees (1)
- honeybee (1)
- honeycomb lattice (1)
- hormones (1)
- hospitalisation (1)
- host cells (1)
- host-cells (1)
- host-pathogen interactions (1)
- human amygdala (1)
- human brain (1)
- human brian endothelium (1)
- human bruchs membrane (1)
- human cells (1)
- human disease (1)
- human evolution (1)
- human immunodeficiency virus (1)
- human impact (1)
- human learning (1)
- human liver cells (1)
- human mineralocorticoid receptor (1)
- human movement (1)
- human multiple-myeloma (1)
- human peripheral blood (1)
- human prostate-cancer (1)
- human receptor kinetics (1)
- human serum albumin (1)
- human sodium iodide symporter (hNIS) (1)
- humanized xenograft model (1)
- humidity (1)
- hunger (1)
- hybrid messenger RNA (1)
- hydrogen regulation (1)
- hydrogen-peroxide (1)
- hyperbolic systems (1)
- hyperkalemia (1)
- hyperphosphataemia (1)
- hyperthermophile (1)
- hypogammaglobulinemia (1)
- hypothalamische Adipositas (1)
- hypotonic (1)
- hypoxia (1)
- iPS Reprogrammierung (1)
- identical twins (1)
- idiopathic inflammatory myopathies (1)
- illness (1)
- illumination (1)
- image correlation spectroscopy (1)
- image properties (1)
- imaginery (1)
- imaging proliferation (1)
- immediate early genes (1)
- immune cell infiltration (1)
- immune escape (1)
- immune modulation (1)
- immune receptors (1)
- immune suppression (1)
- immunoassays (1)
- immunoblotting (1)
- immunocytochemical analysis (1)
- immunodeficiency (1)
- immunosuppression (1)
- immunotherapy (1)
- impact (1)
- implementation (1)
- impulsivity (1)
- imunology (1)
- in silico models (1)
- in vitro (1)
- in vitro kinase assay (1)
- in vivo (1)
- in vivo cell expansion (1)
- in-vitro models (1)
- in-vivo expression (1)
- incentives (1)
- incidence (1)
- inconsistencies (1)
- increases atherosclersosis (1)
- incretin secretion (1)
- incus (1)
- independent predictor (1)
- indoleamine 2,3-dioxygenase (1)
- induced impairment (1)
- induced metabolites (1)
- induced obesity (1)
- inducible factor-I (1)
- induction (1)
- infant growth (1)
- infants (1)
- infections (1)
- infinite dimensions (1)
- inflammatory response (1)
- influenza (1)
- infusion (1)
- inhalation anesthetics (1)
- inhibitor (1)
- inhibitor PAI-1 (1)
- inhibitory control (1)
- inhibitory receptors (1)
- injecting drug users (1)
- innate immunity (1)
- innate lymphoid cells (1)
- inner ear (1)
- inplane spectral weight (1)
- insects (1)
- insights (1)
- instensively managed farmland (1)
- instruction (1)
- integration (1)
- intellectual disability (1)
- intentional binding (1)
- interaction networks (1)
- interaction stress and circadian system (1)
- interaction surfaces (1)
- interconnected systems (1)
- interferon (1)
- interferon alpha (1)
- interleukin-6 (1)
- intermittent exotropia (1)
- international cooperation (1)
- interoception (1)
- intervention study (1)
- intestinal microvascular perfusion (1)
- intestinal mucositis (1)
- intranasal corticosteroids (1)
- intraoperative electrocoicography (1)
- intubation time (1)
- invasive candidiasis (1)
- invasive fungal infections (1)
- inversion techniques (1)
- invertebrate herbivory (1)
- investigators (1)
- iodides (1)
- ionic strength (1)
- ipratropium bromide (1)
- irinotecan (1)
- iron limitation (1)
- iron release (1)
- ischemia (1)
- ischemic brain injury (1)
- ischemic-stroke (1)
- island (1)
- isocaloric intake (1)
- isolation (1)
- isotonic (1)
- journal (1)
- judgement bias (1)
- junction (1)
- kallikrein–kinin system (1)
- kardiale MRT (1)
- karyotype (1)
- karyotype evolution (1)
- katydids orthoptera (1)
- ketogenic diet (1)
- keton bodies (1)
- kidney (1)
- kidney disease; (1)
- kidney function (1)
- kinase Syk (1)
- kinematic analysis (1)
- kinematics (1)
- kinin receptor (1)
- klassischer Stil (1)
- knockout mice (1)
- knowledge acquisition (1)
- knowledge of results (1)
- knowledge-based systems (1)
- kolorektales Karzinom (1)
- kombinierte Divergenzoperation (1)
- kommunikative Ressource (1)
- konditioneller Knockout (1)
- labeling (1)
- laboratory environment (1)
- lactate dehydrogenase (1)
- lactate threshold (1)
- lactic acid bacteria (1)
- lactobacillus (1)
- lactose (1)
- laminin receptor (1)
- land cover (1)
- land use (1)
- land-cover (1)
- land-use (1)
- land-use change (1)
- language (1)
- language development (1)
- language mixing (1)
- lanthanides (1)
- laparoscopic cholecystectomy (1)
- larvae (1)
- larval density (1)
- laser microdissection (1)
- latency (1)
- lateraler Zugang (1)
- lead structure optimization (1)
- leaf-cutting ant (1)
- learning (1)
- learning at workstations (1)
- learning curve (1)
- left-ventricular function (1)
- length of stay (1)
- lepidoptera (1)
- leptogenesis (1)
- lesions (1)
- lidocaine (1)
- life cycle (1)
- life history (1)
- life stage (1)
- ligand incompatibility (1)
- ligand trail (1)
- light scattering (1)
- lilial (1)
- limb development (1)
- lineage (1)
- linear regression analysis (1)
- linguistic morphology (1)
- linguistische Pragmatik (1)
- lipid biosynthesis (1)
- lipid rafts (1)
- lipogenesis (1)
- liquid chromatography (1)
- literary function (1)
- live-attenuated influenza vaccine (1)
- live-cell (1)
- living cells (1)
- living vells (1)
- local enhancement (1)
- localization (1)
- localization microscopy (1)
- locally advanced disease (1)
- location behavior (1)
- locked-in state (1)
- logging (1)
- long terminal repeat (1)
- long-term (1)
- long-term depression (1)
- long-term pain (1)
- longevity (1)
- low birth weight (1)
- lower critical solution temperature (1)
- luciferase (1)
- lung (1)
- lung cancer (1)
- lung injury (1)
- lung transplantation (1)
- lung-cancer (1)
- lymph nodes (1)
- lymphoid-tissue (1)
- lymphoid-tissue lymphomas (1)
- m-RNA (1)
- mC (1)
- mCherry (1)
- mRNA level (1)
- mRNA localization (1)
- mRNA-Metabolismus (1)
- mRNA-Spiegel (1)
- mTOR Inhibitor (1)
- machine learning (1)
- macrovascular (1)
- magnetic anisotropy (1)
- magnetic pi flux (1)
- magnetic resonance imaging (1)
- maize kernels (1)
- major depression (1)
- major histocompatibility complex (1)
- malaria (1)
- malaria parasite (1)
- malaria parasites (1)
- malassimilation (1)
- malignant hyperthermia (1)
- malignant transformation (1)
- malt lymphoma (1)
- mammalian development (1)
- mammalian septins (1)
- mammalian target of rapamycin (1)
- mammary gland (1)
- manganese tricarbonyl complexes (1)
- mantel cell lymphoma (1)
- maps (1)
- marcophages (1)
- marine (1)
- marine bacteria (1)
- marine microalgae (1)
- marine natural product (1)
- marine navigation (1)
- marrow plasma cells (1)
- marrow transplantation (1)
- masked mycotoxins (1)
- masked priming (1)
- mass (1)
- mass-flowering crops (1)
- massively multiplayer online role playing games (1)
- mastitis (1)
- maturation (1)
- mean-field theory (1)
- measles virus (1)
- meat (1)
- mechanics (1)
- mechanisms (1)
- medaka (1)
- media geométrica (1)
- medial prefrontal cortex (1)
- medial prefrontal cortex (mPFC) (1)
- medical and biological imaging (1)
- medical research (1)
- medicine (1)
- medida de la biodiversidad (1)
- medium spiny neurons (1)
- meiotic chromosome dynamics (1)
- meiotic chromosomes (1)
- melanoma cell (1)
- melanomas (1)
- melt electrospinning (1)
- membrane characteristics (1)
- membrane organization (1)
- membrane potential (1)
- membrane structures (1)
- membrane-protein topology (1)
- membrans proteins (1)
- memory (1)
- memory consolidation and extinction (1)
- memory errors (1)
- meningococcal disease (1)
- meningococcal lineages (1)
- menschlicher Einfluss (1)
- merocyanine dyes (1)
- mesenchymal stem and stromal cells (1)
- mesenchymal stem cell (1)
- mesenchymal stem cells (1)
- messenger-RNA decay (1)
- messenger-RNA translation (1)
- meta-analysis based orthology (1)
- metabolic flux analysis (1)
- metabolic network (1)
- metabolic profiling (1)
- metabolic syndrome (1)
- metabolisches Netzwerk (1)
- metabolomic changes (1)
- metabolomics (1)
- metal-organic frameworks (1)
- metamagnetism (1)
- metanalysis (1)
- metapopulation (1)
- metformin (1)
- methylphenidate (1)
- metro map (1)
- miR-126 (1)
- miR-21 (1)
- miR-23a cluster (1)
- miRNA 17-92 Cluster (1)
- micro cavity (1)
- microcephaly (1)
- microna profiles (1)
- microtubule motor (1)
- microvascular (1)
- microvilli (1)
- middle-ear surgery (1)
- migration (1)
- mir-203 (1)
- mismatch negativity (1)
- missing self (1)
- mitochondria (1)
- mitochondrial permeability transition pore (1)
- mitofilin (1)
- mitotic chromosomes (1)
- mittelfristige Ergebnisse (1)
- mixed leukocyte culture (1)
- mixed leukocyte reaction (1)
- mobility (1)
- models (1)
- modified mycotoxins (1)
- modis NDVI (1)
- modulating (1)
- modulators (1)
- mole crickets (1)
- molecular biology (1)
- molecular characterization (1)
- molecular diversity (1)
- molecular dynamics (1)
- molecular imaging (1)
- molecular mass (1)
- molecular structure (1)
- molecular-dynamics simulations (1)
- molecule-metal interfaces (1)
- molekulardynamische Simulationen (1)
- monadic composition (1)
- monetary incentive delay task (1)
- monoallelic expression (1)
- monoclonal gammopathy (1)
- monoclonal-antibodies (1)
- monocytes (1)
- monolayers (1)
- monomodige Laser (1)
- monsters (1)
- mood (1)
- morbid obesity (1)
- morbidity of donor region (1)
- morbilliviruses (1)
- morphine (1)
- morphogenesis (1)
- morphogenetic protein (1)
- morphological adaptions (1)
- morphology (1)
- morris water maze (1)
- mortality (1)
- mosquito (1)
- motility disorders (1)
- motoneurons (1)
- mouse model (1)
- mouse models (1)
- multi-terminal devices (1)
- multi-wavelength (1)
- multicellular tumor spheroids (1)
- multidimensional spectroscopy (1)
- multidrug resistance (1)
- multimodal emotion processing (1)
- multiparameter flow-cytometry (1)
- multiparameter flow-cytpmetry (1)
- multiple myeloma (1)
- multiple system atrophy (1)
- multisensory integration (1)
- multivariate analysis (1)
- multivesicular tubule (1)
- murines Modell der aufsteigenden Harnwegsinfektion (1)
- muscular-dystrophy (1)
- mutation (1)
- mycoses (1)
- mycotoxin derivates (1)
- mycotoxin metabolites (1)
- mycotoxins (1)
- myeloperoxidase (1)
- myenteric plexus (1)
- myoglobin assay (1)
- myokardiale Perfusion (1)
- myopathy (1)
- nab-paclitaxel (1)
- nacreous layer formation (1)
- naloxone (1)
- nanoantenna (1)
- nanodiamond (1)
- nanostructures (1)
- napthalene diimide (1)
- narrative of Judith (1)
- native pollinators (1)
- natively unstructured protein (1)
- natural antisense transcripts (1)
- natural enemies (1)
- natural products (1)
- natural variation (1)
- naturnahe Habitate (1)
- ncRNA (1)
- near infrared spectroscopy (1)
- near-field optics (1)
- neoadjuvant chemotherapy (1)
- neonatal brain (1)
- neonatales Pemphigus-Maus-Modell (1)
- neophobia (1)
- nerve fibres (1)
- nesbitti (1)
- nest building (1)
- networked control systems (1)
- networks (1)
- neural activity (1)
- neural stem-cell (1)
- neuralgia (1)
- neurite bridging (1)
- neurite outgrowth inhibitor (1)
- neurobiology (1)
- neuroimaging (1)
- neuron (1)
- neuron migration (1)
- neuronal differentiation (1)
- neuronal precursor cell (1)
- neuronal primary culture (1)
- neuronale Brückenbildung (1)
- neuronale Vorläuferzelle (1)
- neurone (1)
- neuronopathy (1)
- neuropathology (1)
- neuroprosthetic devices (1)
- neuroprotection (1)
- neuropsychology (1)
- neutrino masses (1)
- neutrino mixing (1)
- neutrophil (1)
- next generation sequencing (1)
- nicht-wettbewerbliche Ziele (1)
- nichtgeminale Rekombination (1)
- nichtkarthesische Bildgebung (1)
- nicotinic receptors (1)
- niedrigmaligne (1)
- nilotinib (1)
- nitrite respiration (1)
- nitrogen status (1)
- no correlation (1)
- non competitive goals (1)
- non-Cartesian Imaging (1)
- non-Hodgkin's lymphoma (1)
- non-hodgkins-lymphoma (1)
- non-ionizing radiation (1)
- non-penetrating glaucoma surgery (1)
- non-small cell lung cancer (1)
- non-verbal communication (1)
- noncoding RNAs (1)
- nonhost plant (1)
- nonlinear control (1)
- nonlinear spectroscopy (1)
- novel (1)
- novobiocin (1)
- nuclear import (1)
- nuclear-pore complexes (1)
- nucleobases (1)
- nucleosynthesis (1)
- nucleotide excision-repair (1)
- nutrition education (1)
- nutritional deficiencies (1)
- nympahlidae (1)
- oaks (1)
- obstructive pulmonary disease (1)
- occupancy (1)
- oculomotor dominance (1)
- odor marks (1)
- of-the-literature (1)
- offene Aufgaben (1)
- oilpalm plantation (1)
- oilseed rape (1)
- oilseeds (1)
- older patients (1)
- olfaction (1)
- olfactory bioassay (1)
- oligonucleotides (1)
- olyelectrolyte domains (1)
- oncogenic transformation (1)
- oncolysis (1)
- oncolytic viral therapy (1)
- oncolytic virus (1)
- opioid peptide (1)
- optical physics (1)
- optical spectroscopy (1)
- optimal solution mapping (1)
- optimization (1)
- oral glucose (1)
- oral mucositis (1)
- orbifrontal cortex (1)
- orbital imaging (1)
- organ dysfunktion (1)
- organ-on-a-chip (1)
- organic molecule (1)
- organic photovoltaics (1)
- organic–metal interface (1)
- organotypic (1)
- orthogonal self-assembly (1)
- orthographic representations (1)
- ortholog (1)
- orthology (1)
- orthology network (1)
- oryzias-latipes (1)
- osteoblasts (1)
- osteoclasts (1)
- osteoprogenitor cells (1)
- osteotropism (1)
- output elasticities (1)
- oviedomycin (1)
- oxaliplatin (1)
- oxidative Stressmarker (1)
- oxidative addition (1)
- oxidative and pH dependent regulation (1)
- oxidative stress marker (1)
- oxidative und pH-abhängige Regulation (1)
- oxides (1)
- oxime ligation (1)
- oxygen/glucose deprivation (1)
- p110alpha (1)
- p38MAPK (1)
- p53 expression (1)
- pFADD (1)
- pICln (1)
- paclitaxel (1)
- pain (1)
- pain sensation (1)
- pancreatic cancer (1)
- parallel evolution (1)
- paralyzed patients (1)
- parasite (1)
- parasitic diseases (1)
- parliamentary interaction (1)
- passiv transfer (1)
- passive avoidance (1)
- patellar tendon (1)
- pathogen-associated molecular patterns (1)
- pathogenesis (1)
- pathometabolism (1)
- pathway (1)
- pathways (1)
- patient (1)
- pattern formation (1)
- patterned semiconductor substrates (1)
- patterns (1)
- peak oxygen uptake (1)
- peak power (1)
- pectoralis major flap (1)
- pedicled flaps (1)
- peginterferon alpha-2B (1)
- penetratin (1)
- penile thrombosis (1)
- people (1)
- peptide (1)
- peptide conjugates (1)
- perceived physical environment (1)
- perception-action (1)
- perception-action coupling (1)
- percutaneus endoscopic gastrostomy (1)
- perineurium (1)
- periodontal diseases (1)
- periodontitis (1)
- peripheral T-cell (1)
- peripheral analgesia (1)
- peripheral blood (1)
- peripheral nervous-system (1)
- peripherer Nerv (1)
- permeability (1)
- personality (1)
- pharmaceutical applications (1)
- pharmacokinetic (1)
- pharmacology (1)
- phase unwrapping (1)
- phased metamorphosis (1)
- phenazine (1)
- phenotypic plasticity (1)
- phonology and reading (1)
- phosphatase (1)
- phosphatidylinositol-3-kinase (1)
- phosphoantigen (1)
- phosphodiesterase-4 inhibitor (1)
- phospholipase A(2) (1)
- phospholipid fatty acids (1)
- phosphorylase isozymes (1)
- phosphorylation sites (1)
- photocurrent (1)
- photodynamic therapy (1)
- photoemission spectroscopy (1)
- photoionisation (1)
- photon statistics (1)
- phylogenetics (1)
- phylogeny (1)
- physical activity (1)
- physical properties (1)
- physical sciences (1)
- physics (1)
- phytohormones (1)
- pi3k-signalweg (1)
- pi3kinase (1)
- picture processing (1)
- pines (1)
- pioglitazone (1)
- pixel purity (1)
- pixel size (1)
- place avoidance task (1)
- placebo (1)
- placebo-controlled trial (1)
- plakortide E. (1)
- plakortis halichondroides (1)
- planar cell polarity (1)
- plant community composition (1)
- plant defenses (1)
- plant diversity (1)
- plant hormones (1)
- plant-animal interaction (1)
- plantago lanceolata (1)
- plants response (1)
- plasma D-dimer (1)
- plasma cells (1)
- plasma membrane (1)
- plasma proteins (1)
- plasmid construction (1)
- plasmodium (1)
- plasmon group velocity (1)
- plasmonic waveguides (1)
- plasmonics (1)
- platelet activation factor (1)
- platelet receptor (1)
- platinum (1)
- platinum complex (1)
- platyfish (1)
- pluripotent stem cells (1)
- pneumona virus (1)
- podoplanin (1)
- polarimetry (1)
- pollinators (1)
- polyadenylation sites (1)
- polycistronic transcription (1)
- polyelectrolyte domains (1)
- polyketide synthase gene (1)
- polymavirus (1)
- polymer (1)
- polymerase-chain-reaktion (1)
- polymorphism (1)
- polystyrene (1)
- polyvinyl chloride (1)
- population-based cohort (1)
- populations (1)
- pose estimation (1)
- post-harvest quality (1)
- post-traumatic stress disorder (1)
- posteroinferior occipitotemporal gyrus (1)
- postherpetic neuralgia (1)
- postoperative Phase (1)
- postoperative care (1)
- posttraumatische Belastungsstörung (1)
- potential marker (1)
- poultry (1)
- pre-school children (1)
- predation (1)
- predation risk (1)
- predictive factors (1)
- predictive marker (1)
- predictors (1)
- predicts recovery (1)
- prepositions (1)
- preschool children (1)
- presynapse (1)
- prevalence (1)
- prevention (1)
- prevention program (1)
- prey growth rate (1)
- priapism (1)
- primary biliary-cirrhosis (1)
- primary breast cancer (1)
- primary cells (1)
- primary human hepatocytes (1)
- primary schoolchildren (1)
- prime visibility (1)
- priming (1)
- proboscis extension response (PER) (1)
- procambarus-clarkii (1)
- product specificity (1)
- products (1)
- profile distances (1)
- progener Formenkreis (1)
- progenitors (1)
- prognostic factor (1)
- progressive supranuclear palsy (1)
- prolactin (1)
- promoter region (1)
- promoters (1)
- propionate (1)
- prosoziales Verhalten (1)
- prosthesis (1)
- protease (1)
- protease inhibitor (1)
- protein HFQ (1)
- protein binding (1)
- protein crystallography (1)
- protein dynamics (1)
- protein families database (1)
- protein interactions (1)
- protein secondary structure (1)
- protein structure (1)
- protein synthesis (1)
- protein-RNA recognition (1)
- protein-bound solutes (1)
- protein-coupled-receptors (1)
- protein-ligand-interaction (1)
- prototypes (1)
- protozoan parasite (1)
- pseudomonas syringae (1)
- psychiatric-hospitalization (1)
- psychiatry (1)
- psycholinguistics (1)
- psychometric properties (1)
- psychopharmacology (1)
- psychosocial stress (1)
- psychotherapy (1)
- psychotic experiences (1)
- pulmonary absorption (1)
- pulmonary artery (1)
- pulmonary artery pressure (1)
- pulmonary circulation (1)
- pulmonary embolism (1)
- pulmonary function (1)
- pulmonata (1)
- pump-probe-spectroscopy (1)
- pupae (1)
- pyracylene (1)
- pyrazine (1)
- pyrrolidine (1)
- périodiques (1)
- qualité (1)
- quantum center (1)
- quantum communications (1)
- quantum control (1)
- quantum criticality (1)
- quantum dot (1)
- quantum dots (1)
- quantum key distribution (1)
- quantum mechanics (1)
- quantum physics (1)
- quantum spin Hall effect (1)
- quantum transport (1)
- quantum-well -wire and -dot devices (1)
- questionaire, day-care, development of children from 13 to 36 months (1)
- questionnaire assessment (1)
- qutenza (1)
- rOCT1 (1)
- race (1)
- radar (1)
- radiation (1)
- radiation-induced migration (1)
- radical prostatectomy (1)
- radio galaxy (1)
- radioiodine therapy (1)
- radiosensibility (1)
- rana temporaria populations (1)
- random forest (1)
- randomisierte Studie (1)
- randomized clinical trial (1)
- randomized controlled-trial (1)
- randomized phase-3 trial (1)
- randomized trial (1)
- randomized-controlled trial (1)
- ranibizumab (1)
- rat hepatocytes (1)
- rat model (1)
- rat small-intestine (1)
- rating scale (1)
- ray solution scattering (1)
- re-aim framework (1)
- reactivation (1)
- reading comprehension test (1)
- reading disability (1)
- reaktive Sauerstoffradikale (1)
- reaktive Sauerstoffspezies (1)
- receptive fields (1)
- receptor (1)
- receptor expression (1)
- receptor gene polymorphism (1)
- receptor related protein (1)
- receptor signaling (1)
- receptor splice variant (1)
- receptor tyrosine kinase (1)
- reciprocal best hit (1)
- recj exonuclease (1)
- recognition (1)
- recombinant proteins (1)
- recommendations (1)
- reconstructed human epidermis (1)
- reconstruction (1)
- recreation-related physical activity (1)
- red blood cells (1)
- red fluorescent protein (1)
- reflection (1)
- reflex (1)
- refractory/relapsed lymphoma (1)
- register (1)
- registration (1)
- regression analysis (1)
- regulation (1)
- regulatory T-cells (1)
- regulatory cells (1)
- regulatory mutations (1)
- regulatory small RNAs (1)
- rehabilitation (1)
- rekombinante Spinnseide (1)
- relevance detection (1)
- reliability (1)
- reminiscence (1)
- remodeling (1)
- remodelling (1)
- remote sequence conservation (1)
- removal (1)
- renal cell carcinoma (1)
- renal disease (1)
- renal failure requiring hemodialysis (1)
- renal system (1)
- rendezvous and docking (1)
- reperfusion injury (1)
- replacement (1)
- replication fork (1)
- replicative stress (1)
- reporter genes (1)
- reprogramming (1)
- requency (1)
- research funds (1)
- research priorities (1)
- resensitization (1)
- residual cardiovascular risk (1)
- resonant photoelectron spectroscopy (1)
- resonators (1)
- resource scheduling (1)
- resource use (1)
- response inhibition (1)
- response regulator (1)
- ressourcenarme Länder (1)
- resting NK cells (1)
- resting-state fMRI (1)
- restrained eaters (1)
- retinal pigment epithelium (1)
- retinotopic organization (1)
- rett (1)
- reward (1)
- reward deficiency syndrome (1)
- rheumatoid arthritis (1)
- rhizophoraceae (1)
- rhodesain (1)
- rhythms (1)
- ribosomal RNA (1)
- ribosome biogenesis (1)
- riboswitch (1)
- riesgo de extinción (1)
- ring-opening polymerization (1)
- risk behavior (1)
- risk profiling (1)
- robust (1)
- rod-to-sphere transition (1)
- roentgenographic assessment (1)
- rofumilast (1)
- roles (1)
- rolling-circle transposons (1)
- root (1)
- roquin (1)
- rtPA (1)
- rumination (1)
- rupture (1)
- ryanodine receptor gene (1)
- s-phase (1)
- sRNA (1)
- saccades (1)
- saccharmyces cerevisiae (1)
- saccharomyes cerevisiae (1)
- safety (1)
- salicylic acid (1)
- salt (1)
- salt stress (1)
- sample (1)
- saproxylic Coleoptera (1)
- sarcoplasmic reticulum (1)
- satellite (1)
- scale (1)
- scar revision surgery (1)
- scavender receptor (1)
- schistosomiasis (1)
- scientific computing (1)
- scoring functions (1)
- scoring system (1)
- screening (1)
- seasonal influenza (1)
- secondary (1)
- secondary metabolomics (1)
- secondary structure (1)
- secreted effector protein (1)
- sections (1)
- see (1)
- seed (1)
- segmentation (1)
- selection (1)
- selective attention (1)
- self-assembly (1)
- self-organization (1)
- self-regulation (1)
- semi-natural habitats (1)
- semiconductor surfaces (1)
- semiotics (1)
- semitendinosus (1)
- sense of agency (1)
- sensitivity (1)
- sensorimotor rhythms (1)
- sequence databases (1)
- sequence motif analysis (1)
- sequences (1)
- sequential introduction (1)
- serotonin (1)
- serotonin transporter gene (1)
- serotonin(1A) receptor (1)
- serum (1)
- sevelamer (1)
- severe fibrosis (1)
- severe sepsis (1)
- sevoflurane (1)
- sex (1)
- sex addiction (1)
- sex determination (1)
- sex-determining region (1)
- shannon index (1)
- shelf life (1)
- shiga toxin (1)
- shingles (1)
- shuttle run test (1)
- signal filtering (1)
- signal transduction (1)
- signal-transduction systems (1)
- signaling (1)
- signaling microdomain (1)
- signaling pathway (1)
- signature (1)
- significance (1)
- significance MGUS (1)
- siliciumhaltige Synthesebausteine (1)
- silicones (1)
- simian foamy viruses (1)
- simpson's index (1)
- single electron transistor (1)
- single molecule microscopy (1)
- single nucleotide polymorphism (1)
- single particle microscopy (1)
- single-nucleotide polymorphisms (1)
- single-stranded-DNA (1)
- single-trial learning (1)
- skeletal metastases (1)
- skeletal muscle (1)
- skeletal myopathy (1)
- skin (1)
- skin tumors (1)
- sleeve gastrectomy (1)
- slowly-binding reversible inhibitor (1)
- small RNA (1)
- small non-coding RNAs (1)
- small nucleolar RNAs (1)
- small organic osmolytes (1)
- small-angle scattering (1)
- small-gain (1)
- smoldering multiple-myeloma (1)
- snow (1)
- snow cover (1)
- snow cover duration (1)
- social actions (1)
- social anxiety (1)
- social communication (1)
- social science research (1)
- socio-demographic (1)
- socioeconomic (1)
- sodium channels (1)
- sofosbuvir (1)
- soft tissue profile (1)
- soleus muscles (1)
- solubility (1)
- soluble-RNAs (1)
- somatic marker hypothesis (1)
- sound production (1)
- spacer (1)
- spatial attention (1)
- species diversity (1)
- species gastropoda (1)
- species richness (1)
- species-energy-theory (1)
- spectroscopy (1)
- spectrum disorder (1)
- speech (1)
- sperm DNA methylation (1)
- spermatocytes (1)
- sphingomyelinase (1)
- spiders (1)
- spin torque device (1)
- spin valve (1)
- spin-orbit coupling (1)
- spin-transfer torque (1)
- spinal cord (1)
- spinal-cord-injury (1)
- spintronics (1)
- spiro hydrocarbons (1)
- spleen (1)
- spliceosomes (1)
- splicing factors (1)
- sponge holicolona-simulans (1)
- sponge-associated actinomyetes (1)
- spontaneously hypertensive rats (1)
- sports and exercise medicine (1)
- spray (1)
- spread (1)
- squalius alburnoides (1)
- stability (1)
- stable-isotope (1)
- stake building (1)
- standardized food images (1)
- starch (1)
- statement (1)
- statische Lokalisierung (1)
- stem cell niche (1)
- stem cells (1)
- stem-cell niche (1)
- sterisch anspruchsvolle Liganden (1)
- stiffness (1)
- stimulated (1)
- stimulation (1)
- stomach (1)
- strawberry (1)
- stream (1)
- streptomyces (1)
- striate cortex (1)
- structure prediction (1)
- structure-activity relationship (1)
- study-group ADSR (1)
- subcellular localization (1)
- subcutaneous fat layer (1)
- subfoveal choroidal neovascularization (1)
- subgroup-B (1)
- subkutan / subcutaneous (1)
- subretinal space (1)
- substance dependence (1)
- substance use disorder (1)
- substrate specificity (1)
- subunit (1)
- succinylcholine (1)
- sucrose responsiveness (1)
- sucrose sensitivity (1)
- sugar absorption (1)
- sulfonylurea (1)
- sunflowers (1)
- super-resolution microscopy (1)
- supercoiling (1)
- supermolecular carrier systems (1)
- supernovae (1)
- superresolution (1)
- supramolecular chemistry (1)
- surface morphology (1)
- surface proteins (1)
- surface water (1)
- surgery (1)
- surgical and invasive medical procedures (1)
- susceptibility loci (1)
- sustained virological response (1)
- suxamethonium (1)
- symbiotic bacteria (1)
- symbiotic fungus (1)
- symptoms (1)
- synapse (1)
- synapse structure (1)
- synapsis (1)
- synaptic localization (1)
- syndrome (1)
- synergistische Effekte (1)
- syntaktische Funktion (1)
- syntaktische Struktur (1)
- synthase (1)
- synthetase (1)
- synthetic D-glucose analogy (1)
- synthetic lethality (1)
- synthetische Letalität (1)
- systematics (1)
- systemic sclerosis (1)
- systems (1)
- systems biology (1)
- t-CWT (1)
- tDCS (1)
- tandem mass-spectra (1)
- target recognition (1)
- targeted metabolite profiling (1)
- targeting (1)
- task switching (1)
- taxonomy (1)
- technological constraints (1)
- teeth (1)
- teichoic acids (1)
- telomere attachment (1)
- temperate forests (1)
- temporal spillover (1)
- temporal-lobe epilepsy (1)
- tension (1)
- terahertz radiation (1)
- term fenofibrate therapy (1)
- term-follow-up (1)
- termites (1)
- tertiary lymphoid structures (1)
- test development (1)
- testis (1)
- tetraaryl pyracene (1)
- tetrahydrodicyclopenta[fg,op]tetracene (1)
- tettigoniidae (1)
- th1/th2 polarization (1)
- thalidomide maintenance (1)
- therapeutic options (1)
- thermoelectrics (1)
- thermoregulation (1)
- thoracic diaphragm (1)
- three-dimensional microscopy (1)
- three-dimensional quantitative structure–activity relationship (1)
- thrombin (1)
- thrombosis (1)
- thyroid (1)
- time series analysis (1)
- time to exhaustion (1)
- time-resolved optical spectroscopy (1)
- time-resolved spectroscopy (1)
- tissue (1)
- tissue characterization (1)
- tissue engineering (1)
- tissue morphogenesis (1)
- tissue-specific enhancers (1)
- tolerance (1)
- tool (1)
- topography (1)
- topological insulator (1)
- torsional energy (1)
- total HIP-arthroplasty (1)
- tousled-like kinases (1)
- toxin (1)
- toxins (1)
- trabecular bone (1)
- trabecular bone-derived mesenchymal stem cell (1)
- trace conditioning (1)
- traction (1)
- trail-mediated apoptosis (1)
- transcranial magnetic stimulation (1)
- transcranial magnetic stimulation (TMS) (1)
- transcription factor FOXP1 (1)
- transcription factor MIZ-1 (1)
- transcriptional start site (1)
- transcriptional uni (1)
- transcriptome analysis (1)
- transcripts (1)
- transfection (1)
- transfer RNA-synthetases (1)
- transformation (1)
- transgenic mice (1)
- transient global ischemia (1)
- transient receptor potential vanilloid 1 (TRPV1) (1)
- transient spectroscopy (1)
- transition metal oxides (1)
- transition metals (1)
- transition state (1)
- translation (1)
- translesion synthesis (1)
- translocation (1)
- transmission electron microscopy (1)
- transmission model (1)
- transport (1)
- transport inhibition assay (1)
- transport systems (1)
- transport-related physical activity (1)
- transposition (1)
- transposon mutagenesis (1)
- treatment options (1)
- tree plantations (1)
- trees (1)
- triarylamine (1)
- trigeminal nerve (1)
- trigeminal neuropathy (1)
- triglyceride accumulation (1)
- triglyceride-rich lipoproteins (1)
- trimethyl-β-cyclodextrin (1)
- tropical dry forest conservation (1)
- tropical ecology (1)
- tropical forest (1)
- tropische Ökologie (1)
- trypanosoma brucei (1)
- tube nutrition (1)
- tumor dormancy (1)
- tumor immune escape (1)
- tumor immunology (1)
- tumor immunosurveillance (1)
- tumor stem cells (1)
- tumor suppressor genes (1)
- tumor tissue (1)
- tumor treatment (1)
- tumor-propagating cells (1)
- tumors (1)
- tundra (1)
- two photon interference (1)
- two-color microscopy (1)
- two-pore domain potassium channels (1)
- type-1 diabetes mellitus (1)
- type-2 diabetes mellitus (1)
- tyrosine phosphorylation (1)
- tyrosine-protein kinase (1)
- ubiquitin (1)
- ultra high energy (1)
- ultra-high risk (1)
- ultrafast measurements (1)
- ultrafast photochemistry (1)
- ultrafast spectroscopy (1)
- unconscious processing (1)
- under five children (1)
- undetermined significance MGUS (1)
- ungegenständliche Erfahrungen (1)
- unilateral recess-resect surgery (1)
- unimaxillär (1)
- universality (1)
- unstructured proteins (1)
- urban-rural gradient (1)
- uremic toxin (1)
- urinary-tract-infection (1)
- uropathogenic Escherichia coli (1)
- utilization (1)
- vaccination (1)
- vaccine (1)
- vaccine development (1)
- vaccinia virus (1)
- vacuolar proton-ATPase (1)
- validity (1)
- variant detection (1)
- variant surface glycoprotein (1)
- variant surface glycoprotein (VSG) (1)
- variants (1)
- vascular access (1)
- vascularization (1)
- vascularized fat construct (1)
- vector cloning (1)
- vegetation phenology (1)
- vegetative state (1)
- velocity (1)
- venous thromboembolic disease (1)
- venous thrombosis (1)
- ventral stream (1)
- ventrikuläre Tachykardie (1)
- verdeckter Beteiligungsaufbau (1)
- vernetze lineare Systeme (1)
- vesicles (1)
- vibration (1)
- vibrational spectroscopy (1)
- vibrio parahaemolyticus (1)
- video gaming masked stimuli (1)
- video-game (1)
- vigilance decrement (1)
- viral clearance (1)
- viral entry (1)
- viral microRNAs (1)
- viral replication (1)
- viral transmission and infection (1)
- virtual screening (1)
- virulence factors (1)
- virulence genes (1)
- virus infection (1)
- virus-infected cells (1)
- visceral fat (1)
- visual cues (1)
- visual learning (1)
- visual perception (1)
- visual resolution deficit (1)
- visual stimuli (1)
- visual-attention (1)
- visuo-motor coordination abilities (1)
- vitro contracture test (1)
- vocabulary (1)
- volatile anesthetics (1)
- volatiles (1)
- voluntary service (1)
- vorsprachliche Entwicklung (1)
- waggle dance (1)
- walking (1)
- wavelet (1)
- weight-gain (1)
- weite Abstimmbarkeit (1)
- well-being (1)
- wheeze (1)
- wheezing (1)
- wild (1)
- wild bees (1)
- wild-type (1)
- word form area (1)
- word order (1)
- work economy (1)
- working memory (1)
- world of warcraft (1)
- worm (1)
- wound healing (1)
- xanthurenic acid (1)
- xeroderma-pigmentosum (1)
- xiphophorus maculatus (1)
- zebrafish (1)
- zeitlicher Spillover (1)
- Ökonometrie (1)
- Ökosystem (1)
- Ökotourismus (1)
- Ölpalmenanbau (1)
- Überexpression (1)
- Übergangsmetallborylen, Borylentransfer, Basenstabilisiertes Borylen, Metathese (1)
- Übergangsmetallkomplexe (1)
- Übergangsmetallverbindungen (1)
- Überlebensrate dentaler Implantate (1)
- Übernahmestrategie (1)
- Übertragbarkeit (1)
- évaluation (1)
- índice de biodiversidad (1)
- γ-glutamyl cycle (1)
- γδ T-Zellen (1)
Institute
- Theodor-Boveri-Institut für Biowissenschaften (124)
- Graduate School of Life Sciences (62)
- Universität - Fakultätsübergreifend (50)
- Physikalisches Institut (38)
- Institut für Psychologie (35)
- Medizinische Klinik und Poliklinik I (35)
- Medizinische Klinik und Poliklinik II (34)
- Neurologische Klinik und Poliklinik (27)
- Klinik und Poliklinik für Psychiatrie, Psychosomatik und Psychotherapie (26)
- Institut für Molekulare Infektionsbiologie (25)
Schriftenreihe
Sonstige beteiligte Institutionen
- Clinical Trial Center (CTC) / Zentrale für Klinische Studien Würzburg (ZKSW) (3)
- Röntgen Center for Complex Material Systems (RCCM), Am Hubland, 97074 W¨urzburg, Germany (2)
- Universitätsklinikum Münster (2)
- Wilhelm-Conrad-Röntgen-Forschungszentrum für komplexe Materialsysteme (2)
- Auftrag der Rummelsberger Dienste für Menschen mit Behinderung gGmbH; Aktion Mensch (1)
- Badisches Landesmuseum Karlsruhe (1)
- CBIO, University of Cape Town, South Africa (1)
- Centre for Political Studies, Jawaharlal Nehru University, New Delhi (1)
- Comprehensive Hearing Center, Department of ORL, Plastic, Aesthetic and Reconstructive Head and Neck Surgery, Würzburg, Germany (1)
- DLR (1)
ResearcherID
- I-5818-2014 (1)
Mini Unmanned Aerial Vehicles (MUAVs) are becoming popular research platform and drawing considerable attention, particularly during the last decade due to their multi-dimensional applications in almost every walk of life. MUAVs range from simple toys found at electronic supermarkets for entertainment purpose to highly sophisticated commercial platforms performing novel assignments like offshore wind power station inspection and 3D modelling of buildings. This paper presents an overview of the main aspects in the domain of distributed control of cooperating MUAVs to facilitate the potential users in this fascinating field. Furthermore it gives an overview on state of the art in MUAV technologies e.g. Photonic Mixer Devices (PMD) camera, distributed control methods and on-going work and challenges, which is the motivation for many researchers all over the world to work in this field.
One of the most often used instruments for the assessment of food cravings is the Food Cravings Questionnaire (FCQ), which consists of a trait (FCQ-T; 39 items) and state (FCQ-S; 15 items) version. Scores on the FCQ-T have been found to be positively associated with eating pathology, body mass index (BMI), low dieting success and increases in state food craving during cognitive tasks involving appealing food stimuli. The current studies evaluated reliability and validity of a reduced version of the FCQ-T consisting of 15 items only (FCQ-T-r). Study 1 was a questionnaire study conducted online among students (N = 323). In study 2, female students (N = 70) performed a working memory task involving food and neutral pictures. Study 1 indicated a one-factorial structure and high internal consistency (α = 0.94) of the FCQ-T-r. Scores of the FCQ-T-r were positively correlated with BMI and negatively correlated with dieting success. In study 2, participants reported higher state food craving after the task compared to before. This increase was positively correlated with the FCQ-T-r. Hours since the last meal positively predicted food craving before the task when controlling for FCQ-T-r scores and the interaction of both variables. Contrarily, FCQ-T-r scores positively predicted food craving after the task when controlling for food deprivation and the interaction term. Thus, trait food craving was specifically associated with state food craving triggered by palatable food-cues, but not with state food craving related to plain hunger. Results indicate high reliability of the FCQ-T-r. Replicating studies that used the long version, small-to-medium correlations with BMI and dieting success could be found. Finally, scores on the FCQ-T-r predicted cue-elicited food craving, providing further support of its validity. The FCQ-T-r constitutes a succinct, valid and reliable self-report measure to efficiently assess experiences of food craving as a trait.
Mitochondrial structure and function is emerging as a major contributor to neuromuscular disease, highlighting the need for the complete elucidation of the underlying molecular and pathophysiological mechanisms. Following a forward genetics approach with N-ethyl-N-nitrosourea (ENU)-mediated random mutagenesis, we identified a novel mouse model of autosomal recessive neuromuscular disease caused by a splice-site hypomorphic mutation in a novel gene of unknown function, DnaJC11. Recent findings have demonstrated that DNAJC11 protein co-immunoprecipitates with proteins of the mitochondrial contact site (MICOS) complex involved in the formation of mitochondrial cristae and cristae junctions. Homozygous mutant mice developed locomotion defects, muscle weakness, spasticity, limb tremor, leucopenia, thymic and splenic hypoplasia, general wasting and early lethality. Neuropathological analysis showed severe vacuolation of the motor neurons in the spinal cord, originating from dilatations of the endoplasmic reticulum and notably from mitochondria that had lost their proper inner membrane organization. The causal role of the identified mutation in DnaJC11 was verified in rescue experiments by overexpressing the human ortholog. The full length 63 kDa isoform of human DNAJC11 was shown to localize in the periphery of the mitochondrial outer membrane whereas putative additional isoforms displayed differential submitochondrial localization. Moreover, we showed that DNAJC11 is assembled in a high molecular weight complex, similarly to mitofilin and that downregulation of mitofilin or SAM50 affected the levels of DNAJC11 in HeLa cells. Our findings provide the first mouse mutant for a putative MICOS protein and establish a link between DNAJC11 and neuromuscular diseases.
The discovery of the Giant Magneto Resistance (GMR) effect in 1988 by Albert Fert [Baib 88] and Peter Grünberg [Bina 89] led to a rapid development of the field of spintronics and progress in the information technology. Semiconductor based spintronics, which appeared later, offered a possibility to combine storage and processing in a single monolithic device. A direct result is reduced heat dissipation. The observation of the spin Seebeck effect by Ushida [Uchi 08] in 2008 launched an increased interest and encouraged research in the field of spin caloritronics. Spintronics is about the coupling of charge and spin transport. Spin caloritronics studies the interaction between heat and spin currents. In contrast to spintronics and its variety of applications, a particular spin-caloritronic device has not yet been demonstrated. However, many of the novel phenomena in spin caloritronics can be detected in most spintronic devices. Moreover, thermoelectric effects might have a significant influence on spintronic device operation. This will be of particular interest for this work. Additional knowledge on the principle of coupling between heat and spin currents uncovers an alternative way to control heat dissipation and promises new device functionalities.
This thesis aims to further extend the knowledge on thermoelectrics in materials with strong spin-orbit coupling, in this case the prototypical ferromagnetic semiconductor (Ga,Mn)As. The study is focused on the thermoelectric / thermomagnetic effects at the interface between a normal metal and the ferromagnetic (Ga,Mn)As. In such systems, the different interfaces provide a condition for minimal phonon drag contribution to the thermal effects. This suggests that only band contributions (a diffusion transport regime) to these effects will be measured.
Chapter 2 begins with an introduction on the properties of the studied material system, and basics on thermoelectrics and spin caloritronics. The characteristic anisotropies of the (Ga,Mn)As density of states (DOS) and the corresponding magnetic properties are described. The DOS and magnetic anisotropies have an impact on the transport prop- erties of the material and that results in effects like tunneling anisotropic magnetores- istance (TAMR) [Goul 04]. Some of these effects will be used later as a reference to the results from thermoelectric / thermomagnetic measurements. The Fingerprint tech- nique [Papp 07a] is also described. The method gives an opportunity to easily study the anisotropies of materials in different device geometries.
Chapter 3 continues with the experimental observation of the diffusion thermopower of (Ga,Mn)As / Si-doped GaAs tunnel junction. A device geometry for measuring the diffusion thermopower is proposed. It consists of a Si - doped GaAs heating channel with a Low Temperature (LT) GaAs / (Ga,Mn)As contact (junction) in the middle of the channel. A single Ti / Au contact is fabricated on the top of the junction. For transport characterization, the device is immersed in liquid He. A heating current technique is used to create a temperature difference by local heating of the electron system on the Si:GaAs side. An AC current at low frequency is sent through the channel and it heats the electron population in it, while the junction remains at liquid He temperature (experimentally con- firmed). A temperature difference arises between the heating channel and the (Ga,Mn)As contact. As a result, a thermal (Seebeck) voltage develops across the junction, which we call tunnelling anisotropic magneto thermopower (TAMT), similar to TAMR. TAMT is detected by means of a standard lock-in technique at double the heating current frequency (at 2f ). The Seebeck voltage is found to be linear with the temperature difference. That dependence suggests a diffusion transport regime. Lattice (phonon drag) contribution to the thermovoltage, which is usually highly nonlinear with temperature, is not observed.
The value of the Seebeck coefficient of the junction at 4.2 K is estimated to be 0.5 µV/K.
It is about three orders of magnitude smaller than the previously reported one [Pu 06]. Subsequently, the thermal voltage is studied in external magnetic fields. It is found that the thermopower is anisotropic with the magnetization direction. The anisotropy is explained with the anisotropies of the (Ga,Mn)As contact. Further, switching events are detected in the thermopower when the magnetic field is swept from negative to positive fields. The switchings remind of a spin valve signal and is similar to the results from previous experiments on spin injection using a (Ga,Mn)As contacts in a non-local detection scheme. That shows the importance of the thermoelectric effects and their possible contribution to the spin injection measurements. A polar plot of the collected switching fields for different magnetization angles reveals a biaxial anisotropy and resembles earlier TAMR measurements of (Ga,Mn)As tunnel junction. A simple cartoon model is introduced to describe and estimate the expected thermopower of the studied junction. The model yields a Fermi level inside of the (Ga,Mn)As valence band. Moreover, the model is found to be in good agreement with the experimental results.
The Nernst effect of a (Ga,Mn)As / GaAs tunnel junction is studied in Chapter 4. A modified device geometry is introduced for this purpose. Instead of a single contact on the top of the square junction, four small contacts are fabricated to detect the Nernst signal. A temperature difference is maintained by means of a heating current technique described in Chapter 3. A magnetic field is applied parallel to the device plane. A voltage drop across two opposite contacts is detected at 2f. It appears that a simple cosine function with a parameter the angle between the magnetization and the [100] crystal direction in the (Ga,Mn)As layer manages to describe this signal which is attributed to the anomalous Nernst effect (ANE) of the ferromagnetic contact. Its symmetry is different than the Seebeck effect of the junction. For the temperature range of the thermopower measurements the ANE coefficient has a linear dependence on the temperature difference (∆T). For higher ∆T, a nonlinear dependence is observed for the coefficient. The ANE coefficient is found to be several orders of magnitude smaller than any Nernst coefficient in the literature. Both the temperature difference and the size of the ANE coefficient require further studies and analysis. Switching events are present in the measured Nernst signal when the magnetic field is swept from positive to negative values. These switchings are related to the switching fields in the ferromagnetic (Ga,Mn)As. Usually, there are two states which are present in TAMR or AMR measurements - low and high resistance. Instead of that, the Nernst signal appears to have three states - high, middle and low thermomagnetic voltage. That behaviour is governed not only by the magnetization, but also by the characteristic of the Nernst geometry.
Chapter 5 summarizes the main observations of this thesis and contains ideas for future work and experiments.
Background
Chronic thromboembolic pulmonary hypertension (CTEPH) is a long-term complication following an acute pulmonary embolism (PE). It is frequently diagnosed at advanced stages which is concerning as delayed treatment has important implications for favourable clinical outcome. Performing a follow-up examination of patients diagnosed with acute PE regardless of persisting symptoms and using all available technical procedures would be both cost-intensive and possibly ineffective. Focusing diagnostic procedures therefore on only symptomatic patients may be a practical approach for detecting relevant CTEPH.
This study aimed to evaluate if a follow-up program for patients with acute PE based on telephone monitoring of symptoms and further examination of only symptomatic patients could detect CTEPH. In addition, we investigated the role of cardiopulmonary exercise testing (CPET) as a diagnostic tool.
Methods
In a prospective cohort study all consecutive patients with newly diagnosed PE (n=170, 76 males, 94 females within 26 months) were recruited according to the inclusion and exclusion criteria. Patients were contacted via telephone and asked to answer standardized questions relating to symptoms. At the time of the final analysis 130 patients had been contacted. Symptomatic patients underwent a structured evaluation with echocardiography, CPET and complete work-up for CTEPH.
Results
37.7%, 25.5% and 29.3% of the patients reported symptoms after three, six, and twelve months respectively. Subsequent clinical evaluation of these symptomatic patients saw 20.4%, 11.5% and 18.8% of patients at the respective three, six and twelve months time points having an echocardiography suggesting pulmonary hypertension (PH). CTEPH with pathological imaging and a mean pulmonary artery pressure (mPAP) ≥ 25 mm Hg at rest was confirmed in eight subjects. Three subjects with mismatch perfusion defects showed an exercise induced increase of PAP without increasing pulmonary artery occlusion pressure (PAOP). Two subjects with pulmonary hypertension at rest and one with an exercise induced increase of mPAP with normal PAOP showed perfusion defects without echocardiographic signs of PH but a suspicious CPET.
Conclusion
A follow-up program based on telephone monitoring of symptoms and further structured evaluation of symptomatic subjects can detect patients with CTEPH. CPET may serve as a complementary diagnostic tool.
The skeleton is a preferred homing site for breast cancer metastasis. To date, treatment options for patients with bone metastases are mostly palliative and the disease is still incurable. Indeed, key mechanisms involved in breast cancer osteotropism are still only partially understood due to the lack of suitable animal models to mimic metastasis of human tumor cells to a human bone microenvironment. In the presented study, we investigate the use of a human tissue-engineered bone construct to develop a humanized xenograft model of breast cancer-induced bone metastasis in a murine host. Primary human osteoblastic cell-seeded melt electrospun scaffolds in combination with recombinant human bone morphogenetic protein 7 were implanted subcutaneously in non-obese diabetic/severe combined immunodeficient mice. The tissue-engineered constructs led to the formation of a morphologically intact 'organ' bone incorporating a high amount of mineralized tissue, live osteocytes and bone marrow spaces. The newly formed bone was largely humanized, as indicated by the incorporation of human bone cells and human-derived matrix proteins. After intracardiac injection, the dissemination of luciferase-expressing human breast cancer cell lines to the humanized bone ossicles was detected by bioluminescent imaging. Histological analysis revealed the presence of metastases with clear osteolysis in the newly formed bone. Thus, human tissue-engineered bone constructs can be applied efficiently as a target tissue for human breast cancer cells injected into the blood circulation and replicate the osteolytic phenotype associated with breast cancer-induced bone lesions. In conclusion, we have developed an appropriate model for investigation of species-specific mechanisms of human breast cancer-related bone metastasis in vivo.
In den letzten Jahren hat die myokardiale MR-Perfusionsbildgebung als nichtinvasives Verfahren zur Darstellung von funktionellen Veränderungen des Myokards für die Diagnostik der KHK zunehmend an Bedeutung gewonnen. Während in den letzten 20 Jahren die kardiale MRT überwiegend bei einer Magnetfeldstärke von 1,5 T durchge-führt wurde und dies auch immer noch wird, findet aktuell eine rasante Verbreitung von MR-Systemen höherer Feldstärken statt. Von der neuen Hochfeldtechnik erhofft man sich vor allem, je nach Anwendung, eine deutliche Verbesserung der Bildqualität mit höherer räumlicher und zeitlicher Auflösung, wodurch der diagnostische Nutzen noch weiter gesteigert werden könnte.
In der vorliegenden Arbeit wurden mittels First-Pass-MR-Bildgebung bei einer Magnet-feldstärke von 3 T quantitative Werte für die myokardiale Perfusion von 20 gesunden Probanden unter Ruhebedingungen bestimmt.
Sowohl die erhobenen absoluten Perfusionswerte (0,859 ml/g/min im Mittel) als auch die Standardabweichung des mittleren MBF (0,298 ml/g/min) entsprechen den Messungen aus den früheren Publikationen dieser Arbeitsgruppe. In der Gesamtzusammenschau bisher veröffentlichter Perfusionsstudien zeigt sich eine relativ große Variabilität der publizierten Ruheflüsse. Dabei liegt der absolute MBF dieser Arbeit im mittleren Wertebereich dieser Streubreite. Er lässt sich auch mit den in PET-Studien ermittelten Ergebnissen in Einklang bringen, welche als Goldstandard zur Bestimmung der absoluten myokardialen Perfusion beim Menschen gelten.
Die vorliegende Arbeit bestätigt die bereits in anderen 3 T-Studien untersuchten Vorteile der Hochfeld-MRT. Die höhere Magnetfeldstärke ermöglicht durch das größere SNR eine signifikant bessere räumliche Auflösung und besticht vor allem durch die hohe Bildqualität. Dies könnte bei der Erkennung kleiner, subendokardial gelegener Perfusionsdefekte sowie der Erstellung von transmuralen Perfusionsgradienten von Bedeutung sein und verspricht neben einer Reduktion von Partialvolumeneffekten auch eine Verminderung von „dark rim“-Artefakten.
Um diese Vorteile entsprechend nutzen zu können, wird die Entwicklung von Methoden zur pixelweisen Bestimmung der absoluten Flüsse und farblich kodierten Darstellung derselben in Form von Perfusionskarten ein weiterer Schritt in Richtung klinisch einsetzbare Diagnostik sein. Eine Voraussetzung hierfür ist die Entwicklung einer exakten und sehr stabilen Bewegungskorrektur in weiterführenden Studien.
Durch den Wechsel zu einer höheren Magnetfeldstärke von 3 T und den sich daraus ergebenden Vorteilen kann das Potential der MR-Perfusionsbildgebung, insbesondere der Bestimmung quantitativer Perfusionswerte, im Bereich der nichtinvasiven KHK-Diagnostik zukünftig weiter gesteigert werden.
[Purpose] A wide variety of accelerometer tools are used to estimate human movement, but there are no adequate data relating to gait symmetry parameters in the context of knee osteoarthritis. This study's purpose was to evaluate a 3D-kinematic system using body-mounted sensors (gyroscopes and accelerometers) on the trunk and limbs. This is the first study to use spectral analysis for data post processing. [Subjects] Twelve patients with unilateral knee osteoarthritis (OA) (10 male) and seven age-matched controls (6 male) were studied. [Methods] Measurements with 3-D accelerometers and gyroscopes were compared to video analysis with marker positions tracked by a six-camera optoelectronic system (VICON 460, Oxford Metrics). Data were recorded using the 3D-kinematic system. [Results] The results of both gait analysis systems were significantly correlated. Five parameters were significantly different between the knee OA and control groups. To overcome time spent in expensive post-processing routines, spectral analysis was performed for fast differentiation between normal gait and pathological gait signals using the 3D-kinematic system. [Conclusions] The 3D-kinematic system is objective, inexpensive, accurate and portable, and allows long-term recordings in clinical, sport as well as ergonomic or functional capacity evaluation (FCE) settings. For fast post-processing, spectral analysis of the recorded data is recommended.
[Purpose] A wide variety of accelerometer tools are used to estimate human movement, but there are no adequate data relating to gait symmetry parameters in the context of knee osteoarthritis. This study's purpose was to evaluate a 3D-kinematic system using body-mounted sensors (gyroscopes and accelerometers) on the trunk and limbs. This is the first study to use spectral analysis for data post processing. [Subjects] Twelve patients with unilateral knee osteoarthritis (OA) (10 male) and seven age-matched controls (6 male) were studied. [Methods] Measurements with 3-D accelerometers and gyroscopes were compared to video analysis with marker positions tracked by a six-camera optoelectronic system (VICON 460, Oxford Metrics). Data were recorded using the 3D-kinematic system. [Results] The results of both gait analysis systems were significantly correlated. Five parameters were significantly different between the knee OA and control groups. To overcome time spent in expensive post-processing routines, spectral analysis was performed for fast differentiation between normal gait and pathological gait signals using the 3D-kinematic system. [Conclusions] The 3D-kinematic system is objective, inexpensive, accurate and portable, and allows long-term recordings in clinical, sport as well as ergonomic or functional capacity evaluation (FCE) settings. For fast post-processing, spectral analysis of the recorded data is recommended.
The subject of this thesis is the controllability of interconnected linear systems, where the interconnection parameter are the control variables. The study of accessibility and controllability of bilinear systems is closely related to their system Lie algebra. In 1976, Brockett classified all possible system Lie algebras of linear single-input, single-output (SISO) systems under time-varying output feedback. Here, Brockett's results are generalized to networks of linear systems, where time-varying output feedback is applied according to the interconnection structure of the network. First, networks of linear SISO systems are studied and it is assumed that all interconnections are independently controllable. By calculating the system Lie algebra it is shown that accessibility of the controlled network is equivalent to the strong connectedness of the underlying interconnection graph in case the network has at least three subsystems. Networks with two subsystems are not captured by these proofs. Thus, we give results for this particular case under additional assumption either on the graph structure or on the dynamics of the node systems, which are both not necessary. Additionally, the system Lie algebra is studied in case the interconnection graph is not strongly connected. Then, we show how to adapt the ideas of proof to networks of multi-input, multi-output (MIMO) systems. We generalize results for the system Lie algebra on networks of MIMO systems both under output feedback and under restricted output feedback. Moreover, the case with generalized interconnections is studied, i.e. parallel edges and linear dependencies in the interconnection controls are allowed. The new setting demands to distinguish between homogeneous and heterogeneous networks. With this new setting only sufficient conditions can be found to guarantee accessibility of the controlled network. As an example, networks with Toeplitz interconnection structure are studied.
This thesis consists of two parts of original experimental work, its evaluation, and in- terpretation. Its final goal is to investigate dynamical charge transfer (CT) at a hetero- molecular interface with resonant photoelectron spectroscopy (RPES). In order to achieve this goal preliminary studies have been necessary. First two hetero-molecular inter- faces that exhibit adequate structural properties as well as an appropriate photoelec- tron spectroscopy (PES) spectrum of the valence regime have been identified. The de- sired CT analysis with RPES of these hetero-molecular systems is then conducted on the basis of the knowledge gained by previous RPES studies of homo-molecular sys- tems.
The characterization of hetero-molecular films on single crystal Ag surfaces in the first part of this thesis is performed with high resolution core level PES and valence PES. The reproduction of the core level PES data with reference spectra of homo-molecular films allows me to determine which molecule is in direct contact to the Ag surface and which one is situated in higher layers (not the first one). Due to the direct correspon- dence of core level and valence PES the assignment of features in the spectra of the latter technique can be achieved with the identification of the contributions extracted from the evaluation of the data of the former technique. It is found that the systems PTCDA on one monolayer (ML) of SnPc on Ag(111) and CuPc/1 ML PTCDA/Ag(111) are stable at 300 K which means that no significant layer exchange occurs for these systems. In contrast a vertical exchange of CuPc and PTCDA molecules is observed for PTCDA de- posited on top of 1 ML CuPc/Ag(111). Up to a coverage of approximately 0.5 ML of PTCDA molecules these diffuse into the first layer, replace CuPc molecules, and con- sequently force them into higher layers. Above a coverage of approximately 0.5 ML of PTCDA molecules these are also found in higher layers. The search for a promising system for the intended RPES study then leads to an investigation of hetero-molecular films with a combination of F4TCNQ and PTCDA molecules on Ag(110) within the same approach. Depositing F4TCNQ molecules onto a 1 ML PTCDA/Ag(110) film in the herringbone phase at 300 K results in an instable hetero-organic system which un- dergoes a layer exchange. Hereby PTCDA molecules in the first layer are replaced by F4TCNQ molecules similar to the behavior of the system PTCDA/1 ML CuPc/Ag(111). Switching the order of the preparation steps leads to a stable film of PTCDA/1.0 ML F4TCNQ/Ag(110) at 300 K. Among the stable hetero-molecular films only the system CuPc/1 ML PTCDA/Ag(111) exhibits the required wetting growth of the first two layers at 300 K and a valence PES spectrum with energetically separable molecular orbital signals in the same intensity range. Thus this system is identified to be appropriate for a detailed analysis with RPES.
The unexpected findings of vertical exchanges in the hetero-molecular films at 300 K motivate a study of the behavior at elevated temperatures for all systems investigated before. Therein it is revealed that annealing 1.5 ML SnPc/1 ML PTCDA/Ag(111) and
1.0 ML PTCDA/1 ML SnPc/Ag(111) to a temperature above the desorption temperature of molecules not in direct contact to the Ag(111) surface results in a 1 ML SnPc/Ag(111) film in both cases. Hence at elevated temperatures (approximately above 420 K) SnPc molecules replace PTCDA molecules in the first layer on Ag(111). At higher temper- atures (approximately above 470 K) PTCDA molecules and SnPc molecules situated above the first layer then desorb from the 1 ML SnPc/Ag(111) sample. Annealing all hetero-molecular films with CuPc and PTCDA molecules on Ag(111) to 570 K leads to a sample with CuPc and PTCDA molecules in the first and only layer. Depending on the initial CuPc coverage different ratios of both molecules are obtained. With a CuPc coverage of exactly 1 ML, or above, films with PTCDA coverages of approxi- mately 0.1–0.2 ML are produced. So at elevated temperatures CuPc molecules replace PTCDA molecules in the first layer of the system CuPc/1 ML PTCDA/Ag(111). Anal- ogously the layer exchange at 300 K for the system PTCDA/1 ML CuPc/Ag(111) is reversed at elevated temperatures. In the case of SnPc and CuPc coverages below 1 ML annealing vertical hetero-molecular systems with PTCDA on Ag(111) up to 570 K re- sults in a single layer of mixed hetero-molecular films with lateral long range order. In this way the system CuPc + PTCDA/Ag(111) is prepared and then characterized as a proper system for a detailed analysis with RPES. Additional annealing experiments of hetero-organic films consisting of F4TCNQ and PTCDA molecules on Ag(110) with an F4TCNQ coverage of 1.0 ML (and above) end in a submonolayer (sub-ML) film of F4TCNQ/Ag(110) that exhibits a contribution of amorphous carbon. Consequently, it can be concluded that at elevated temperatures part of the F4TCNQ molecules decom- pose.
In the second part of this thesis homo-molecular multilayer samples and (sub-)ML films on single crystalline metal surfaces are investigated with RPES in order to enable the final RPES study of vertical and lateral hetero-molecular interface systems. First a pho- ton energy (hν) dependent intensity variation of (groups of) molecular orbital signals of exemplary multilayer films (NTCDA and coronene) is studied and explained on the basis of the local character of the electronic transitions in near edge x-ray absorption fine structure (NEXAFS) spectroscopy in combination with the real space probability den- sity of the contributing molecular orbitals. This simple approach is found to be able to correctly describe relative intensity variations by orders of magnitude while it fails for hν dependent relative intensity changes in the same order of magnitude. After that the hν dependent line-shape evolution of an energetically separated molecular orbital signal of a CuPc multilayer is discussed in relation to small molecules in the gas phase and explained with an effect of electron vibration coupling. Through a comparison of the hν dependent line-shape evolution of the highest occupied molecular orbital (HOMO) of a CuPc with a SnPc multilayer the molecule specific character of this effect is identified. Then the same effect with either two (or more) electronic transitions or multiple coupling vibrational modes is observed for a coronene multilayer. Thereafter the influence of the adsorption on metal surfaces on this effect is studied and discussed with special emphasis on a possible contribution by features which are related to dynamical interface CT. For a sub-ML of SnPc/Au(111) no variation with respect to a SnPc multilayer film is detected while for a sub-ML of CuPc/Au(111) less intensity is distributed into the high binding energy (EB) part of the HOMO signal with respect to the corresponding multilayer film. In the RPES data of a sub-ML of coronene/Ag(111) a resonance specific variation of the hν dependent line-shape evolution of the HOMO signal is found by the revelation of a change of this effect with respect to the coronene multilayer data in only one of the two NEXAFS resonances. All these findings are consistently explained within one effect and a common set of parameters, namely all quantities that characterize the potential energy surfaces involved in the RPES process. Through that an alternative explanation that re- lies on dynamical CT can be excluded which influences the following CT analysis with RPES.
Three criteria for such an analysis of dynamical interface CT with RPES are identified. In the system coronene on Ag(111) a low EB feature is related to metal-molecule inter- face CT through the assignment of a particular final state and hence named CT state. In the EB region of the frontier molecular orbital signals of the molecule-metal inter- face systems with a signal from the lowest unoccupied molecular orbital (LUMO) in direct valence PES a broad line-shape is measured in RPES. This finding is related to interface CT by a possible explanation that emerges through the comparison to the line- shape of the CT state. The constant kinetic energy (EK ) features detected for several molecule-metal interfaces constitute the third criterion for a CT analysis with RPES. For the molecule-metal interface systems without a LUMO signal in direct valence PES the energy of these features can be calculated with the assignment of the responsible decay channel in combination with explicitly given simplifying assumptions. Through that the involvement of metal-molecule interface CT in the generation of these constant EK fea- tures is demonstrated. The RPES data of the lateral and the vertical hetero-molecular interface, identified in the first part, is then scanned for these three CT criteria. Thereby neither for the lateral hetero-molecular system CuPc + PTCDA/Ag(111) nor for the verti- cal hetero-molecular system CuPc/1 ML PTCDA/Ag(111) dynamical hetero-molecular interface CT can be confirmed. In the former system the molecule-metal interface in- teraction is found to dominate the physics of the system in RPES while in the latter system no hints for a significant hybridization at the CuPc-PTCDA interface can be revealed
The diversity of actinomycetes associated with marine sponges collected off Fsar Reef (Saudi Arabia) was investigated in the present study. Forty-seven actinomycetes were cultivated and phylogenetically identified based on 16S rRNA gene sequencing and were assigned to 10 different actinomycete genera. Eight putatively novel species belonging to genera Kocuria, Mycobacterium, Nocardia, and Rhodococcus were identified based on sequence similarity values below 98.2% to other 16S rRNA gene sequences available in the NCBI database. PCR-based screening for biosynthetic genes including type I and type II polyketide synthases (PKS-I, PKS-II) as well as nonribosomal peptide synthetases (NRPS) showed that 20 actinomycete isolates encoded each at least one type of biosynthetic gene. The organic extracts of nine isolates displayed bioactivity against at least one of the test pathogens, which were Gram-positive and Gram-negative bacteria, fungi, human parasites, as well as in a West Nile Virus protease enzymatic assay. These results emphasize that marine sponges are a prolific resource for novel bioactive actinomycetes with potential for drug discovery.
The subjective experience of controlling events in the environment alters the perception of these events. For instance, the interval between one's own actions and their consequences is subjectively compressed—a phenomenon known as intentional binding. In two experiments, we studied intentional binding in a social setting in which actions of one agent prompted a second agent to perform another action. Participants worked in pairs and were assigned to a “leader” and a “follower” role, respectively. The leader's key presses triggered (after a variable interval) a tone and this tone served as go signal for the follower to perform a keypress as well. Leaders and followers estimated the interval between the leader's keypress and the following tone, or the interval between the tone and the follower's keypress. The leader showed reliable intentional binding for both intervals relative to the follower's estimates. These results indicate that human agents experience a pre-reflective sense of agency for genuinely social consequences of their actions.
Action feedback affects the perception of action-related objects beyond actual action success
(2014)
Successful object-oriented action typically increases the perceived size of aimed target objects. This phenomenon has been assumed to reflect an impact of an actor's current action ability on visual perception. The actual action ability and the explicit knowledge of action outcome, however, were confounded in previous studies. The present experiments aimed at disentangling these two factors. Participants repeatedly tried to hit a circular target varying in size with a stylus movement under restricted feedback conditions. After each movement they were explicitly informed about the success in hitting the target and were then asked to judge target size. The explicit feedback regarding movement success was manipulated orthogonally to actual movement success. The results of three experiments indicated the participants' bias to judge relatively small targets as larger and relatively large targets as smaller after explicit feedback of failure than after explicit feedback of success. This pattern was independent of the actual motor performance, suggesting that the actors' evaluations of motor actions may bias perception of target objects in itself.
Background
International research for acute myocardial infarction lacks comparisons of whole health systems. We assessed time trends for care and outcomes in Sweden and the UK.
Methods
We used data from national registries on consecutive patients registered between 2004 and 2010 in all hospitals providing care for acute coronary syndrome in Sweden and the UK. The primary outcome was all-cause mortality 30 days after admission. We compared effectiveness of treatment by indirect casemix standardisation. This study is registered with ClinicalTrials.gov, number NCT01359033.
Findings
We assessed data for 119 786 patients in Sweden and 391 077 in the UK. 30-day mortality was 7·6% (95% CI 7·4–7·7) in Sweden and 10·5% (10·4–10·6) in the UK. Mortality was higher in the UK in clinically relevant subgroups defined by troponin concentration, ST-segment elevation, age, sex, heart rate, systolic blood pressure, diabetes mellitus status, and smoking status. In Sweden, compared with the UK, there was earlier and more extensive uptake of primary percutaneous coronary intervention (59% vs 22%) and more frequent use of β blockers at discharge (89% vs 78%). After casemix standardisation the 30-day mortality ratio for UK versus Sweden was 1·37 (95% CI 1·30–1·45), which corresponds to 11 263 (95% CI 9620–12 827) excess deaths, but did decline over time (from 1·47, 95% CI 1·38–1·58 in 2004 to 1·20, 1·12–1·29 in 2010; p=0·01).
Interpretation
We found clinically important differences between countries in acute myocardial infarction care and outcomes. International comparisons research might help to improve health systems and prevent deaths.
Background: RGS9-deficient mice show drug-induced dyskinesia but normal locomotor activity under unchallenged conditions. Results: Genes related to Ca2+ signaling and their functions were regulated in RGS9-deficient mice.
Conclusion: Changes in Ca2+ signaling that compensate for RGS9 loss-of-function can explain the normal locomotor activity in RGS9-deficient mice under unchallenged conditions.
Significance: Identified signaling components may represent novel targets in antidyskinetic therapy. The long splice variant of the regulator of G-protein signaling 9 (RGS9-2) is enriched in striatal medium spiny neurons and dampens dopamine D2 receptor signaling. Lack of RGS9-2 can promote while its overexpression prevents drug-induced dyskinesia. Other animal models of drug-induced dyskinesia rather pointed towards overactivity of dopamine receptor-mediated signaling. To evaluate changes in signaling pathways mRNA expression levels were determined and compared in wild-type and RGS9-deficient mice. Unexpectedly, expression levels of dopamine receptors were unchanged in RGS9-deficient mice, while several genes related to Ca2+ signaling and long-term depression were differentially expressed when compared to wild type animals. Detailed investigations at the protein level revealed hyperphosphorylation of DARPP32 at Thr34 and of ERK1/2 in striata of RGS9-deficient mice. Whole cell patch clamp recordings showed that spontaneous synaptic events are increased (frequency and size) in RGS9-deficient mice while long-term depression is reduced in acute brain slices. These changes are compatible with a Ca2+-induced potentiation of dopamine receptor signaling which may contribute to the drug-induced dyskinesia in RGS9-deficient mice.
Adenosinrezeptoren werden auf nahezu allen Körperzellen exprimiert und übernehmen dort vielfältige und wichtige Funktionen. Auch auf diversen Tumorzelllinien konnten bereits Adenosinrezeptoren nachgewiesen und – je nach Subtyp – mit Pro- oder Anti-tumor-Effekten in Zusammenhang gebracht werden.
In dieser Arbeit wurden Gebärmutterhalskrebszellen sowie endometriale und triple-negative Brustkrebszellen auf Expression und mögliche Funktionen von Adenosinrezep-toren untersucht. Da spezifische Antikörper bis heute nicht verfügbar sind, wurde ein pharmakologischer Ansatz mit subtypspezifischen Agonisten und Antagonisten gewählt.
In Radioliganden-Bindungsassays, konnte nachgewiesen werden, dass sich auf der Zer-vixkarzinom-Zelllinie SiHa und der Brustkrebs-Zelllinie HCC1806 Adenosinrezeptoren des Subtyps A1 befinden. Die endometrialen Krebszelllinien Ishikawa und HEC-1-A exprimieren Rezeptoren vom Subtyp A1 und A2A. A3-Adenosinrezeptoren wurden auf keiner der untersuchten Zelllinien gefunden.
Der Nachweis von A2B-Rezeptoren kann mit dem Radioliganden-Bindungsassay nicht erbracht werden, da bislang kein Radioligand bekannt ist, der eine ausreichende Affini-tät besitzt, um diesen Subtyp zweifelsfrei nachweisen zu können.
Obwohl die Mehrheit der untersuchten Zelllinien Adenosinrezeptoren exprimiert, konnte ein signifikanter Effekt auf die Adenylatcyclase bei Stimulation der auf den Zellen vorhandenen Adenosinrezeptoren nur bei den HEC-1-A-Zellen festgestellt werden. Auch auf funktionelle A2B-Rezeptoren fand sich im Adenylatcyclaseassy kein Hinweis.
Im durchgeführten Kristallviolettassay zeigte sich ein proapoptotischer Effekt auf Ishi-kawa- und HEC-1-A-Zellen bei hohen Adenosin-Konzentrationen (100 µM). Die im BrdU-Assay gemessene Proliferationsrate hingegen änderte sich nach Vorbehandlung mit Adenosin nicht. Das metabolisch stabilere NECA (in Kombination mit ADA) hatte im Kristallviolettassay einen stärkeren Einfluss auf die Apoptoserate der jeweiligen Zelllinie als Adenosin und auch im BrdU-Assay sank die Menge an inkorporiertem BrdU. Ein Synergismus zwischen Stimulation von Adenosinrezeptoren und diversen Todesliganden bzw. Chemotherapeutika konnte nicht nachgewiesen werden.
Freies extrazelluläres Adenosin kann auch aus dem Abbau von ATP generiert werden, wenn Zellen die Ektonukleotidasen CD39 und CD73 exprimieren. Aufgrund der im-munsuppressiven Wirkung von Adenosin können diese Enzyme T-Zell- und NK-Zellantworten im Mikromilieu von Tumoren hemmen. Die durchflusszytometrische Analyse von HEC-1-A- und Ishikawa-Zellen zeigte zwar, dass die Expression von CD39 und CD73 nach Stimulation der Adenosinrezeptoren unverändert blieb. Die Ex-pression von Enzymen, lässt aber vermuten, dass die Zellen in vivo von Adenosin profi-tieren könnten. Angesichts der in vitro Daten, die allenfalls einen wachstumshemmen-den Effekt von Adenosin zeigten, könnte die vorrangige Wirkung von Adenosin im Tumormikromilieu tatsächlich auf der Inhibition von Immunantworten beruhen. Mög-licherweise würden die Rezeptoren dann in erster Linie als Sensoren dienen.
Weitere Forschungsarbeit wird helfen, die Rolle der Adenosinrezeptoren im Tumorge-schehen vollständig zu verstehen und möglicherweise für die Krebstherapie nutzbar zu machen.
Adipose tissue defects and related pathologies still represent major challenges in reconstructive surgery. Based on to the paradigm ‘replace with alike’, adipose tissue is considered the ideal substitute material for damaged soft tissue [1-3]. Yet the transfer of autologous fat, particularly larger volumes, is confined by deficient and unpredictable long term results, as well as considerable operative morbidity at the donor and recipient site [4-6], calling for innovative treatment options to improve patient care.
With the aim to achieve complete regeneration of soft tissue defects, adipose tissue engineering holds great promise to provide functional, biologically active adipose tissue equivalents. Here, especially long-term maintenance of volume and shape, as well as sufficient vascularization of engineered adipose tissue represent critical and unresolved challenges [7-9]. For adipose tissue engineering approaches to be successful, it is thus essential to generate constructs that retain their initial volume in vivo, as well as to ensure their rapid vascularization to support cell survival and differentiation for full tissue regeneration [9,10]. Therefore, it was the ultimate goal of this thesis to develop volume-stable 3D adipose tissue constructs and to identify applicable strategies for sufficient vascularization of engineered constructs. The feasibility of the investigated approaches was verified by translation from in vitro to in vivo as a critical step for the advancement of potential regenerative therapies.
For the development of volume-stable constructs, the combination of two biomaterials with complementary properties was successfully implemented. In contrast to previous approaches in the field using mainly non-degradable solid structures for mechanical protection of developing adipose tissue [11-13], the combination of a cell-instructive hydrogel component with a biodegradable porous support structure of adequate texture was shown advantageous for the generation of volume-stable adipose tissue. Specifically, stable fibrin hydrogels previously developed in our group [14] served as cell carrier and supported the adipogenic development of adipose-derived stem cells (ASCs) as reflected by lipid accumulation and leptin secretion. Stable fibrin gels were thereby shown to be equally supportive of adipogenesis compared to commercial TissuCol hydrogels in vitro. Using ASCs as a safe source of autologous cells [15,16] added substantial practicability to the approach. To enhance the mechanical strength of the engineered constructs, porous biodegradable poly(ε caprolactone)-based polyurethane (PU) scaffolds were introduced as support structures and shown to exhibit adequately sized pores to host adipocytes as well as interconnectivity to allow coherent tissue formation and vascularization. Low wettability and impaired cell attachment indicated that PU scaffolds alone were insufficient in retaining cells within the pores, yet cytocompatibility and differentiation of ASCs were adequately demonstrated, rendering the PU scaffolds suitable as support structures for the generation of stable fibrin/PU composite constructs (Chapter 3).
Volume-stable adipose tissue constructs were generated by seeding the pre-established stable fibrin/PU composites with ASCs. Investigation of size and weight in vitro revealed that composite constructs featured enhanced stability relative to stable fibrin gels alone. Comparing stable fibrin gels and TissuCol as hydrogel components, it was found that TissuCol gels were less resilient to degradation and contraction. Composite constructs were fully characterized, showing good cell viability of ASCs and strong adipogenic development as indicated by functional analysis via histological Oil Red O staining of lipid vacuoles, qRT-PCR analysis of prominent adipogenic markers (PPARγ, C/EBPα, GLUT4, aP2) and quantification of leptin secretion. In a pilot study in vivo, investigating the suitability of the constructs for transplantation, stable fibrin/PU composites provided with a vascular pedicle gave rise to areas of well-vascularized adipose tissue, contrasted by insufficient capillary formation and adipogenesis in constructs implanted without pedicle. The biomaterial combination of stable fibrin gels and porous biodegradable PU scaffolds was thereby shown highly suitable for the generation of volume-stable adipose tissue constructs in vivo, and in addition, the effectiveness of immediate vascularization upon implantation to support adipose tissue formation was demonstrated (Chapter 4).
Further pursuing the objective to investigate adequate vascularization strategies for engineered adipose tissue, hypoxic preconditioning was conducted as a possible approach for in vitro prevascularization. In 2D culture experiments, analysis on the cellular level illustrated that the adipogenic potential of ASCs was reduced under hypoxic conditions when applied in the differentiation phase, irrespective of the oxygen tension encountered by the cells during expansion. Hypoxic treatment of ASCs in 3D constructs prepared from stable fibrin gels similarly resulted in reduced adipogenesis, whereas endothelial CD31 expression as well as enhanced leptin and vascular endothelial growth factor (VEGF) secretion indicated that hypoxic treatment indeed resulted in a pro-angiogenic response of ASCs. Especially the observed profound regulation of leptin production by hypoxia and the dual role of leptin as adipokine and angiogenic modulator were considered an interesting connection advocating further study. Having confirmed the hypothesis that hypoxia may generate a pro-angiogenic milieu inside ASC-seeded constructs, faster vessel ingrowth and improved vascularization as well as an enhanced tolerance of hypoxia-treated ASCs towards ischemic conditions upon implanatation may be expected, but remain to be verified in rodent models in vivo (Chapter 5).
Having previously been utilized for bone and cartilage engineering [17-19], as well as for revascularization and wound healing applications [20-22], stromal-vascular fraction (SVF) cells were investigated as a novel cell source for adipose tissue engineering. Providing cells with adipogenic differentiation as well as vascularization potential, the SVF was applied with the specific aim to promote adipogenesis and vascularization in engineered constructs in vivo. With only basic in vitro investigations by Lin et al. addressing the SVF for adipose repair to date [23], the present work thoroughly investigated SVF cells for adipose tissue construct generation in vitro, and in particular, pioneered the application of these cells for adipose tissue engineering in vivo.
Initial in vitro experiments compared SVF- and ASC-seeded stable fibrin constructs in different medium compositions employing preadipocyte (PGM-2) and endothelial cell culture medium (EGM-2). It was found that a 1:1 mixture of PGM-2 and EGM-2, as previously established for co-culture models of adipogenesis [24], efficiently maintained cells with adipogenic and endothelial potential in SVF-seeded constructs in short and long-term culture setups. Observations on the cellular level were supported by analysis of mRNA expression of characteristic adipogenic and endothelial markers. In preparation of the evaluation of SVF-seeded constructs under in vivo conditions, a whole mount staining (WMS) method, facilitating the 3D visualization of adipocytes and blood vessels, was successfully established and optimized using native adipose tissue as template (Chapter 6).
In a subcutaneous nude mouse model, SVF cells were, for the first time in vivo, elucidated for their potential to support the functional assembly of vascularized adipose tissue. Investigating the effect of adipogenic precultivation of SVF-seeded stable fibrin constructs in vitro prior to implantation on the in vivo outcome, hormonal induction was shown beneficial in terms of adipocyte development, whereas a strong vascularization potential was observed when no adipogenic inducers were added. Via histological analysis, it was proven that the developed structures were of human origin and derived from the implanted cells. Applying SVF cells without precultivation in vitro but comparing two different fibrin carriers, namely stable fibrin and TissuCol gels, revealed that TissuCol profoundly supported adipose formation by SVF cells in vivo. This was contrasted by only minor SVF cell development and a strong reduction of cell numbers in stable fibrin gels implanted without precultivation. Histomorphometric analysis of adipocytes and capillary structures was conducted to verify the qualitative results, concluding that particularly SVF cells in TissuCol were highly suited for adipose regeneration in vivo. Employing the established WMS technique, the close interaction of mature adipocytes and blood vessels in TissuCol constructs was impressively shown and via species-specific human vimentin staining, the expected strong involvement of implanted SVF cells in the formation of coherent adipose tissue was confirmed (Chapter 7).
With the development of biodegradable volume-stable adipose tissue constructs, the application of ASCs and SVF cells as two promising cell sources for functional adipose regeneration, as well as the thorough evaluation of strategies for construct vascularization in vitro and in vivo, this thesis provides valuable solutions to current challenges in adipose tissue engineering. The presented findings further open up new perspectives for innovative treatments to cure soft tissue defects and serve as a basis for directed approaches towards the generation of clinically applicable soft tissue substitutes.
Each year millions of plastic and reconstructive procedures are performed to regenerate soft tissue defects after, for example, traumata, deep burns or tumor resections. Tissue engineered adipose tissue grafts are a promising alternative to autologous fat transfer or synthetic implants to meet this demand for adipose tissue. Strategies of tissue engineering, especially the use of cell carriers, provide an environment for better cell survival, an easier positioning and supplemented with the appropriate conditions a faster vascularization in vivo. To successfully engineer an adipose tissue substitute for clinical use, it is crucial to know the actual intended application. In some areas, like the upper and lower extremities, only a thin subcutaneous fat layer is needed and in others, large volumes of vascularized fat grafts are more desirable. The use and interplay of stem cells and selected scaffolds were investigated and provide now a basis for the generation of fitted and suitable substitutes in two different application areas.
Complex injuries of the upper and lower extremities, in many cases, lead to excessive scarring. Due to severe damage to the subcutaneous fat layer, a common sequela is adhesion formation to mobile structures like tendons, nerves, and blood vessels resulting in restricted motion and disabling pain [Moor 1996, McHugh 1997]. In order to generate a subcutaneous fat layer to cushion scarred tissue after substantial burns or injuries, different collagen matrices were tested for clinical handling and the ability to support adipogenesis. When testing five different collagen matrices, PermacolTM and StratticeTM showed promising characteristics; additionally both possess the clinical approval. Under culture conditions, only PermacolTM, a cross-linked collagen matrix, exhibited an excellent long-term stability. Ranking nearly on the same level was StratticeTM, a non-cross-linked dermal scaffold; it only exhibited a slight shrinkage. All other scaffolds tested were severely compromised in stability under culture conditions. Engineering a subcutaneous fat layer, a construct would be desirable with a thin layer of emerging fat for cushioning on one side, and a non-seeded other side for cell migration and host integration. With PermacolTM and StratticeTM, it was possible to produce constructs with ASC (adipose derived stem cells) seeded on one side, which could be adipogenically differentiated. Additionally, the thickness of the cell layer could be varied. Thereby, it becomes possible to adjust the thickness of the construct to the surrounding tissue. In order to reduce the pre-implantation time ex vivo and the costs, the culture time was varied by testing different induction protocols. An adipogenic induction period of only four days was demonstrated to be sufficient to obtain a substantial adipogenic differentiation of the applied ASC. Thus, seeded with ASC, PermacolTM and StratticeTM are suitable scaffolds to engineer subcutaneous fat layers for reconstruction of the upper and lower extremities, as they support adipogenesis and are appropriately thin, and therefore would not compromise the cosmesis.
For the engineering of large-volume adipose tissue, adequate vascularization still represents a major challenge. With the objective to engineer vascularized fat pads, it is important to consider the slow kinetics of revascularization in vivo. Therefore, a decellularized porcine jejunum with pre-existing vascular structures and pedicles to connect to the host vasculature or the circulation of a bioreactor system was used. In a first step, the ability of a small decellularized jejunal section was tested for cell adhesion and for supporting adipogenic differentiation of hASC mono-cultures. Cell adhesion and adipogenic maturation of ASC seeded on the jejunal material was verified through histological and molecular analysis. After the successful mono-culture, the goal was to establish a MVEC (microvascular endothelial cells) and ASC co-culture; suitable culture conditions had to be found, which support the viability of both cell types and do not interfere with the adipogenic differentiation. After the elimination of EGF (epidermal growth factor) from the co-culture medium, substantial adipogenic maturation was observed. In the next step, a large jejunal segment (length 8 cm), with its pre-existing vascular structures and arterial/venous pedicles, was connected to the supply system of a custom-made bioreactor. After successful reseeding the vascular structure with endothelial cells, the lumen was seeded with ASC which were then adipogenically induced. Histological and molecular examinations confirmed adipogenic maturation and the existence of seeded vessels within the engineered construct. Noteworthily, a co-localization of adipogenically differentiating ASC and endothelial cells in vascular networks could be observed. So, for the first time a vascularized fat construct was developed in vitro, based on the use of a decellularized porcine jejunum. As this engineered construct can be connected to a supply system or even to a patient vasculature, it is versatile in use, for example, as transplant in plastic and reconstruction surgery, as model in basic research or as an in vitro drug testing system.
To summarize, in this work a promising substitute for subcutaneous fat layer reconstruction, in the upper and lower extremities, was developed, and the first, as far as reported, in vitro generated adipose tissue construct with integrated vascular networks was successfully engineered.
Magnetic Resonance Imaging (MRI) is a non-invasive medical imaging technique, that is rou- tinely used in clinical practice for detection and diagnosis of a wide range of different diseases. In MRI, no ionizing radiation is used, making even repeated application unproblematic. This is an important advantage over other common imaging methods such as X-rays and Computer To- mography. One major drawback of MRI, however, are long acquisition times and associated high costs of experiments. Since the introduction of MRI, several important technical developments have been made to successfully reduce acquisition times. In this work, novel approaches were developed to increase the efficiency of MRI acquisitions.
In Chapter 4, an improved radial turbo spin-echo (TSE) combined acquisition and reconstruction strategy was introduced. Cartesian turbo spin-echo sequences [3] are widely used especially for the detection and diagnosis of neurological pathologies, as they provide high SNR images with both clinically important proton density and T2 contrasts. TSE acquisitions combined with radial sampling are very efficient, since it is possible to obtain a number of ETL images with different contrasts from a single radial TSE measurement [56–58]. Conventionally, images with a particular contrast are obtained from both radial and Cartesian TSE acquisitions by combining data from different echo times into a single image. In the radial case, this can be achieved by employing k-space weighted image contrast (KWIC) reconstruction. In KWIC, the center region of k-space is filled exclusively with data belonging to the desired contrast while outer regions also are assembled with data acquired at other echo times. However, this data sharing leads to mixed contrast contributions to both Cartesian and radial TSE images. This is true especially for proton density weighted images and therefore may reduce their diagnostic value.
In the proposed method, an adapted golden angle reordering scheme is introduced for radial TSE acquisitions, that allows a free choice of the echo train length and provides high flexibility in image reconstruction. Unwanted contrast contaminations are greatly reduced by employing a narrow-band KWIC filter, that restricts data sharing to a small temporal window around the de- sired echo time. This corresponds to using fewer data than required for fully sampled images and consequently leads to images exhibiting aliasing artifacts. In a second step, aliasing-free images are obtained using parallel imaging. In the neurological examples presented, the CG-SENSE algorithm [42] was chosen due to its stable convergence properties and its ability to reconstruct arbitrarily sampled data. In simulations as well as in different in vivo neurological applications, no unwanted contrast contributions could be observed in radial TSE images reconstructed with the proposed method. Since this novel approach is easy to implement on today’s scanners and requires low computational power, it might be valuable for the clinical breakthrough of radial TSE acquisitions.
In Chapter 5, an auto-calibrating method was introduced to correct for stimulated echo contribu- tions to T2 estimates from a mono-exponential fit of multi spin-echo (MSE) data. Quantification of T2 is a useful tool in clinical routine for the detection and diagnosis of diseases as well as for tis- sue characterization. Due to technical imperfections, refocusing flip angles in a MSE acquisition deviate from the ideal value of 180○. This gives rise to significant stimulated echo contributions to the overall signal evolution. Therefore, T2 estimates obtained from MSE acquisitions typically are notably higher than the reference. To obtain accurate T2 estimates from MSE acquisitions, MSE signal amplitudes can be predicted using the extended phase graph (EPG, [23, 24]) algo- rithm. Subsequently, a correction factor can be obtained from the simulated EPG T2 value and applied to the MSE T2 estimates. However, EPG calculations require knowledge about refocus- ing pulse amplitudes, T2 and T1 values and the temporal spacing of subsequent echoes. While the echo spacing is known and, as shown in simulations, an approximate T1 value can be assumed for high ratios of T1/T2 without compromising accuracy of the results, the remaining two parameters are estimated from the data themselves. An estimate for the refocusing flip angle can be obtained from the signal intensity ratio of the second to the first echo using EPG. A conventional mono- exponential fit of the MSE data yields a first estimate for T2. The T2 correction is then obtained iteratively by updating the T2 value used for EPG calculations in each step. For all examples pre- sented, two iterations proved to be sufficient for convergence. In the proposed method, a mean flip angle is extracted across the slice. As shown in simulations, this assumption leads to greatly reduced deviations even for more inhomogeneous slice profiles. The accuracy of corrected T2 values was shown in experiments using a phantom consisting of bottles filled with liquids with a wide range of different T2 values. While T2 MSE estimates were shown to deviate significantly from the spin-echo reference values, this is not the case for corrected T2 values. Furthermore, applicability was demonstrated for in vivo neurological experiments.
In Chapter 6, a new auto-calibrating parallel imaging method called iterative GROG was pre- sented for the reconstruction of non-Cartesian data. A wide range of different non-Cartesian schemes have been proposed for data acquisition in MRI, that present various advantages over conventional Cartesian sampling such as faster acquisitions, improved dynamic imaging and in- trinsic motion correction. However, one drawback of non-Cartesian data is the more complicated reconstruction, which is ever more problematic for non-Cartesian parallel imaging techniques. Iterative GROG uses Calibrationless Parallel Imaging by Structured Low-Rank Matrix Completion (CPI) for data reconstruction. Since CPI requires points on a Cartesian grid, it cannot be used to directly reconstruct non-Cartesian data. Instead, Grappa Operator Gridding (GROG) is employed in a first step to move the non-Cartesian points to the nearest Cartesian grid locations. However, GROG requires a fully sampled center region of k-space for calibration. Combining both methods in an iterative scheme, accurate GROG weights can be obtained even from highly undersampled non-Cartesian data. Subsequently, CPI can be used to reconstruct either full k- space or a calibration area of arbitrary size, which can then be employed for data reconstruction with conventional parallel imaging methods.
In Chapter 7, a new 2D sampling scheme was introduced consisting of multiple oscillating effi- cient trajectories (MOET), that is optimized for Compressed Sensing (CS) reconstructions. For successful CS reconstruction of a particular data set, some requirements have to be met. First, ev- ery data sample has to carry information about the whole object, which is automatically fulfilled for the Fourier sampling employed in MRI. Additionally, the image to be reconstructed has to be sparse in an arbitrary domain, which is true for a number of different applications. Last, data sam- pling has to be performed in an incoherent fashion. For 2D imaging, this important requirement of CS is difficult to achieve with conventional Cartesian and non-Cartesian sampling schemes. Ra- dial sampling is often used for CS reconstructions of dynamic data despite the streaking present in undersampled images. To obtain incoherent aliasing artifacts in undersampled images while at the same time preserving the advantages of radial sampling for dynamic imaging, MOET com- bines radial spokes with oscillating gradients of varying amplitude and alternating orientation orthogonal to the readout direction. The advantage of MOET over radial sampling in CS re- constructions was demonstrated in simulations and in in vivo cardiac imaging. MOET provides superior results especially when used in CS reconstructions with a sparsity constraint directly in image space. Here, accurate results could be obtained even from few MOET projections, while the coherent streaking artifacts present in the case of radial sampling prevent image recovery even for smaller acceleration factors. For CS reconstructions of dynamic data with sparsity constraint in xf-space, the advantage of MOET is smaller since the temporal reordering is responsible for an important part of incoherency. However, as was shown in simulations of a moving phantom and in the reconstruction of ungated cardiac data, the additional spatial incoherency provided by MOET still leads to improved results with higher accuracy and may allow reconstructions with higher acceleration factors.