Refine
Has Fulltext
- yes (346)
Is part of the Bibliography
- yes (346)
Year of publication
Document Type
- Journal article (293)
- Doctoral Thesis (46)
- Book article / Book chapter (2)
- Conference Proceeding (2)
- Review (2)
- Preprint (1)
Language
- English (346) (remove)
Keywords
- Infektionsbiologie (57)
- Escherichia coli (27)
- Candida albicans (17)
- escherichia coli (11)
- gene expression (11)
- RNA-seq (9)
- Staphylococcus aureus (9)
- Immunologie (8)
- expression (8)
- infection (8)
Author
- Hacker, Jörg (79)
- Vogel, Jörg (38)
- Moll, Heidrun (31)
- Ohlsen, Knut (27)
- Förstner, Konrad U. (21)
- Hertlein, Tobias (20)
- Ott, M. (20)
- Morschhäuser, Joachim (17)
- Sharma, Cynthia M. (17)
- Barquist, Lars (15)
- Westermann, Alexander J. (15)
- Goebel, W. (14)
- Szalay, Aladar A. (11)
- Marre, R. (10)
- Bischler, Thorsten (8)
- Chen, Nanhai G. (8)
- Marincola, Gabriella (8)
- Ramírez-Zavala, Bernardo (8)
- Röllinghoff, Martin (8)
- Ziebuhr, Wilma (8)
- Bender, L. (7)
- Sharan, Malvika (7)
- Weibel, Stephanie (7)
- Gentschev, Ivaylo (6)
- Goebel, W (6)
- Hof, H. (6)
- Holzgrabe, Ulrike (6)
- Hughes, C. (6)
- Ludwig, B. (6)
- Pradel, Gabriele (6)
- Schmoll, T. (6)
- Zhang, Qian (6)
- Dandekar, Thomas (5)
- Fischer, Rainer (5)
- Goebel, Werner (5)
- Jann, K. (5)
- Krüger, Ines (5)
- Lalk, Michael (5)
- Mottola, Austin (5)
- Saliba, Antoine-Emmanuel (5)
- Scheffer, J. (5)
- Schmidt, G. (5)
- Schurigt, Uta (5)
- Siegel, T. Nicolai (5)
- Simon, Markus M. (5)
- Stritzker, Jochen (5)
- Van Die, I. (5)
- Yu, Yong A. (5)
- Adelfinger, Marion (4)
- Bartfeld, Sina (4)
- Blum, G. (4)
- Eulalio, Ana (4)
- Fröhlich, Kathrin S. (4)
- Gerovac, Milan (4)
- Gupta, Shishir K. (4)
- Hilgeroth, Andreas (4)
- Hoschützky, H. (4)
- Imdahl, Fabian (4)
- Knapp, S. (4)
- Korhonen, T. K. (4)
- König, W. (4)
- Lopez, Daniel (4)
- Masic, Anita (4)
- Metzger, Marco (4)
- Morschhäuser, J. (4)
- Oelschlaeger, Tobias A. (4)
- Ott, Manfred (4)
- Papenfort, Kai (4)
- Schoen, Christoph (4)
- Schwanfelder, Sonja (4)
- Srivastava, Mugdha (4)
- Alzheimer, Mona (3)
- Beijer, Barbro (3)
- Dobrindt, Ulrich (3)
- Domhan, Cornelius (3)
- Fuchs, Harald (3)
- Gillitzer, Reinhard (3)
- Glaser, Jan (3)
- Götz, Friedrich (3)
- Haberkorn, Uwe (3)
- Heesemann, J. (3)
- Heidrich, Nadja (3)
- Hofmann, Elisabeth (3)
- Ibrahim, Eslam S. (3)
- Jakob, Peter (3)
- Jarick, Marcel (3)
- Kleist, Christian (3)
- Klug, Gabriele (3)
- Li, Lei (3)
- Marciniak, Tessa (3)
- Meinel, Lorenz (3)
- Mielich-Süss, Benjamin (3)
- Mier, Walter (3)
- Mitchell, Graham F. (3)
- Mühlberg, Eric (3)
- Pernitzsch, Sandy R. (3)
- Plogmann, R. (3)
- Rdest, U. (3)
- Reimann, Andreas (3)
- Reinhardt, Richard (3)
- Scheuermayer, Matthias (3)
- Schillberg, Stefan (3)
- Schroten, H. (3)
- Schulte, Leon N. (3)
- Schwarz, Stefan (3)
- Solbach, Werner (3)
- Spiegel, Holger (3)
- Svensson, Sarah L. (3)
- Uhl, Philipp (3)
- Umstätter, Florian (3)
- Walles, Heike (3)
- Zimmermann, Stefan (3)
- Aguilar, Carmen (2)
- Amich, Jorge (2)
- Antoraz, Sergio (2)
- Bandyra, Katarzyna J. (2)
- Basse-Luesebrink, Thomas Christian (2)
- Bauriedl, Saskia (2)
- Beiss, Veronique (2)
- Bender, Larisa (2)
- Berghoff, Bork A. (2)
- Bergmans, H. (2)
- Blank, Christine (2)
- Boes, Alexander (2)
- Bogdan, Christian (2)
- Boinett, Christine J. (2)
- Brakhage, Axel A. (2)
- Cain, Amy K. (2)
- Chen, Chun-Hao (2)
- Debes, A. (2)
- Diessner, Joachim (2)
- Dischinger, Ulrich (2)
- Donat, Stefanie (2)
- Donat, Ulrike (2)
- Dreher, Liane (2)
- Dugar, Gaurav (2)
- Düvel, H. (2)
- Ehrig, Klaas (2)
- Emmrich, F. (2)
- Engelmann, Susanne (2)
- Falkenhagen, U. (2)
- Fassnacht, Martin (2)
- Fendel, Rolf (2)
- Firdessa, Rebuma (2)
- Fong, Yuman (2)
- Frank, Benjamin (2)
- Fraunholz, Martin J. (2)
- Frentzen, Alexa (2)
- Förstner, Konrad (2)
- Gardner, Paul P. (2)
- Geibel, Sebastian (2)
- Geiger, Tobias (2)
- Gildor, Tsvia (2)
- Groh, Janos (2)
- Haddad, Daniel (2)
- Hagedorn, Gregor (2)
- Hanisch, F. G. (2)
- Hansen, Elisabeth E. (2)
- Hardt, Wolf-Dietrich (2)
- Hasinger, Julia (2)
- Hazra, Sudipta (2)
- Heckel, Tobias (2)
- Heisig, Martin (2)
- Hess, Michael (2)
- Homberger, Christina (2)
- Hon, Chung-Chau (2)
- Hopke, Elisa (2)
- Hughes, Colin (2)
- Hung, Sophia (2)
- Härtl, Barbara (2)
- Jakob, Peter Michael (2)
- Jarchau, T. (2)
- Jäger, Dominik (2)
- Kingsley, Robert A. (2)
- Kircher, Stefan (2)
- Klika, Karel D. (2)
- Koltzenburg, Claudia (2)
- Kornitzer, Daniel (2)
- Kramer, Michael D. (2)
- Krappmann, Sven (2)
- Kretschmer, Dorothee (2)
- Kuehn, Andrea (2)
- König, B. (2)
- Langbein-Laugwitz, Johanna (2)
- Liong, Olivia (2)
- Lottspeich, F. (2)
- Luisi, Ben F. (2)
- Mano, Miguel (2)
- Masota, Nelson E. (2)
- Maudet, Claire (2)
- Mayho, Matthew (2)
- Meyer, P. (2)
- Michaux, Charlotte (2)
- Middendorf, Barbara (2)
- Mietchen, Daniel (2)
- Mietrach, Nicole (2)
- Minocha, Rashmi (2)
- Mitchell, G. F. (2)
- Müller, Dorothee (2)
- Narberhaus, Franz (2)
- Nerz, Gaby (2)
- Ngwa, Che Julius (2)
- Nieselt, Kay (2)
- Oesterreich, Babett (2)
- Orskov, I. (2)
- Osmanoglu, Özge (2)
- Otto, Christoph (2)
- Overlöper, Aaron (2)
- Paprotka, Kerstin (2)
- Parkhill, Julian (2)
- Parkkinen, J. (2)
- Pere, A. (2)
- Peterson, Lisa (2)
- Popp, Christina (2)
- Prester, Marlot (2)
- Rico, Sergio (2)
- Rudel, Thomas (2)
- Sauer, Markus (2)
- Schlosser, Andreas (2)
- Schmauch, Christian (2)
- Schmitz, Ruth A. (2)
- Schneider, György (2)
- Schneider, Johannes (2)
- Schoenfelder, Sonja M. K. (2)
- Schultheis, Martina (2)
- Schweinlin, Matthias (2)
- Seethaler, Marius (2)
- Sellin, Mikael E. (2)
- Seubert, Carolin (2)
- Severinov, Konstantin (2)
- Seyfried, Florian (2)
- Simon, M. M. (2)
- Sternberg, Michael J. E. (2)
- Stigloher, Christian (2)
- Sturm, Volker (2)
- Szalay, Aladar (2)
- Tawk, Caroline (2)
- Tschäpe, H. (2)
- Tschäpe, Helmut (2)
- Venturini, Elisa (2)
- Wahn, V. (2)
- Wallaschek, Nina (2)
- Wass, Mark N. (2)
- Wencker, Freya D. R. (2)
- Weyler, Michael (2)
- Wheeler, Nicole E. (2)
- Wintermeyer, E. (2)
- Wolz, Christiane (2)
- Yepes, Ana (2)
- Yu, Sung-Huan (2)
- Zingler, G. (2)
- Abda, Ebrahim M. (1)
- Abdelmohsen, Usama R. (1)
- Abdelwahab, Tassnim (1)
- Abouelfetouh, Alaa (1)
- Achtmann, M. (1)
- Ackermann, Martin (1)
- Adalbert, Robert (1)
- Addai-Mensah, Otchere (1)
- Ade, Carsten Patrick (1)
- Afonso-Grunz, Fabian (1)
- Agarwal, Shruti (1)
- Agarwal, Vaibhav (1)
- Aguilar, Richard J. (1)
- Ahrens, Christian H. (1)
- Akash, Aman (1)
- Albert-Weißenberger, Christiane (1)
- Albrecht, Dirk (1)
- Almasi, Anna (1)
- Almeida-e-Silva, Danillo C. (1)
- Altenhoff, Adrian (1)
- Altuvia, Shoshy (1)
- Ameni, Gobena (1)
- Aminake, Makoah Nigel (1)
- Amstalden, Maria Cecilia (1)
- Angermeier, Hilde Gabriele (1)
- Antonacci, Caroline (1)
- Appelt-Menzel, Antje (1)
- Appenzeller, Silke (1)
- Araujo, Gabriel H. M. (1)
- Arends, Mark J. (1)
- Arkowitz, Robert (1)
- Arkowitz, Robert A. (1)
- Arndt, Hans-Dieter (1)
- Aseffa, Abraham (1)
- Ashraf, Kerolos (1)
- Au, Joyce (1)
- BKC, Dukka (1)
- Babbitt, Patricia C. (1)
- Babila, Julius Tachu (1)
- Babski, Julia (1)
- Backofen, Rolf (1)
- Bae, Taeok (1)
- Balasubramanian, Srikkanth (1)
- Balkenhol, Johannes (1)
- Bang, H. (1)
- Bankapur, Asma R. (1)
- Bar-Yosef, Hagit (1)
- Bargsten, Joachim W. (1)
- Barthels, Fabian (1)
- Basse-Lüsebrink, Thomas (1)
- Basse-Lüsebrink, Thomas C. (1)
- Bauchart, Philippe Michel Paul (1)
- Baud, Jessica (1)
- Baumeister, Stefan (1)
- Bauwens, Andreas (1)
- Becher, Dörte (1)
- Beck, Susanne (1)
- Becker, Anke (1)
- Becker, Karsten (1)
- Becker, Svetlana (1)
- Behet, Marije C. (1)
- Beilhack, Andreas (1)
- Bekele, Shiferaw (1)
- Bekeredjian-Ding, Isabelle (1)
- Belair, Cédric (1)
- Belin, Laurence J. (1)
- Ben-Hur, Asa (1)
- Ben-Zvi, Tamar (1)
- Bennett, Richard J. (1)
- Benso, Alfredo (1)
- Berg, Stefan (1)
- Berger, Allison A. (1)
- Berger, Harald (1)
- Berger, Rudolf (1)
- Bergmiller, Tobias (1)
- Bernecker, Steffen (1)
- Bertsche, Ute (1)
- Betsova, Darina (1)
- Bhat, Prajwal (1)
- Bielaszewska, Martina (1)
- Bierlmeier, Jan (1)
- Biggs, Patrick J. (1)
- Binninger, Linda (1)
- Binöder, Kerstin (1)
- Biran, Dvora (1)
- Biswas, Kajal (1)
- Bitzer, Michael (1)
- Blum, Gabriele (1)
- Blättner, Sebastian (1)
- Boehm, Alexander (1)
- Boelhauve, Marc (1)
- Boller, Klaus (1)
- Bolscher, Judith M. (1)
- Bonas, Ulla (1)
- Bonneau, Richard (1)
- Borriss, Rainer (1)
- Bouaziz, Serge (1)
- Boyny, Aziza (1)
- Braun, V. (1)
- Bremer, Belinda U. (1)
- Bremm, K. D. (1)
- Brenner, Steven E. (1)
- Brombacher, Frank (1)
- Brotchie, Jonathan M. (1)
- Bruce, Heather A. (1)
- Bruchhagen, Christin (1)
- Bryson, Kevin (1)
- Brzuszkiewicz, Elzbieta (1)
- Bröker, Barbara M. (1)
- Buckel, Lisa (1)
- Burian, Marc (1)
- Böhm, Lena (1)
- Böttcher, Bettina (1)
- Caffrey, Connor R. (1)
- Caldelari, Isabelle (1)
- Cao, Renzhi (1)
- Carew, Amanda (1)
- Carson, Joshua (1)
- Cartron, Michael (1)
- Casadio, Rita (1)
- Cejuela, Juan M. (1)
- Chabas, Sandrine (1)
- Chakraborty, Trinad (1)
- Chao, Yanjie (1)
- Chapman, Samuel (1)
- Chen, Ching-Tai (1)
- Cheng, Jianlin (1)
- Cheng, Wen-Hui (1)
- Cheung, Man Kit (1)
- Chihara, Kotaro (1)
- Chindera, Kantaraja (1)
- Chirinos, E. (1)
- Christen, A. (1)
- Christophides, Georges K. (1)
- Cibrian-Uhalte, Elena (1)
- Citiulo, Francesco (1)
- Clare, Simon (1)
- Clark, Wyatt T. (1)
- Cliffe, Laura (1)
- Coenye, Tom (1)
- Coleman, Michael (1)
- Connor, Thomas R. (1)
- Coombs, Graham H (1)
- Coppée, Jean-Yves (1)
- Cornelis, Pierre (1)
- Correia Santos, Sara (1)
- Cozzetto, Domenico (1)
- Crabbé, Aurélie (1)
- Cross, A. (1)
- Cruz, Ana Rita (1)
- Cull, Benjamin (1)
- Cummins, Carla (1)
- D'Andrea, Daniel (1)
- Dalton, James (1)
- Dangwal, Seema (1)
- Daniel, Rolf (1)
- Darfeuille, Fabien (1)
- Das, Sayoni (1)
- Das, Sudip (1)
- Davern, K. M. (1)
- Dawson, Natalie L. (1)
- De Brot, Marina (1)
- De Groodt, Lilian P. M. T. (1)
- De Reuse, Hilde (1)
- Dechering, Koen J. (1)
- Deforce, Dieter (1)
- Degenkolb, Thomas (1)
- Dembek, Marcin (1)
- Demicrioglu, Dogan Doruk (1)
- Denny, Paul (1)
- Derese, Yohannes (1)
- Dessimoz, Christophe (1)
- Di Carlo, Stefano (1)
- Diaz, Margarita (1)
- Diekert, Gabriele (1)
- Dierolf, Franziska (1)
- Dietrich, Oliver (1)
- Dimastrogiovanni, Daniela (1)
- Dingemans, Josef (1)
- Dinglasan, Rhoel R. (1)
- Distler, Ute (1)
- Dittrich, Marcus (1)
- Djordjevic, Marko (1)
- Dogan, Tunca (1)
- Dolowschiak, Tamas (1)
- Dougan, Gordon (1)
- Dragin, Loïc (1)
- Dunkel, Nico (1)
- Dunker, Christine (1)
- Däullary, Thomas (1)
- Díaz, Margerita (1)
- Ebert, Regina (1)
- Ebner, Patrick (1)
- Ecker, Andrea (1)
- Eckstein, Marie Therese (1)
- Edgerton, Mira (1)
- Edgue, Gueven (1)
- Ehret, W. (1)
- Ehrhardt, Christina (1)
- Ehricht, Ralf (1)
- Eichmann, K. (1)
- Eichmann, Klaus (1)
- Eijssen, Lars (1)
- Eikmeier, Julian (1)
- Eilers, Ursula (1)
- El Mouali, Youssef (1)
- ElShal, Sarah (1)
- Eldai, Hisham (1)
- Elgrably-Weiss, Maya (1)
- Emmerling, P. (1)
- Emódy, Levente (1)
- Emödy, L. (1)
- Ene, Iuliana V. (1)
- Engstler, Markus (1)
- Erenso, Girume (1)
- Escobar, Hugo Murua (1)
- Esken, Jens (1)
- Espina, Laura (1)
- Evguenieva-Hackenberg, Elena (1)
- Fagan, Robert P. (1)
- Fairweather, Neil F. (1)
- Falda, Marco (1)
- Fan, Ben (1)
- Fan, Sook-Ha (1)
- Fang, Hai (1)
- Fasske, E. (1)
- Fechter, Pierre (1)
- Feller, Tatjana (1)
- Felmy, Boas (1)
- Feng, Shou (1)
- Fernandes Rodrigues, Juliany Cola (1)
- Fernández, José M. (1)
- Ferrari, Carlo (1)
- Fey, Christina (1)
- Fey, Philipp (1)
- Feßler, Andrea T. (1)
- Findeiß, Sven (1)
- Finger, Tamara (1)
- Finne, J. (1)
- Fischer, G. (1)
- Fischer, Gunter (1)
- Fischer, Hans-Martin (1)
- Flamand, Louis (1)
- Fontana, Paolo (1)
- Foster, Simon J. (1)
- Foulger, Rebecca E. (1)
- Franco-Echevarría, Elsa (1)
- Frank, Roland (1)
- Franke, Christian (1)
- Franz-Wachtel, Mirita (1)
- François, Patrice (1)
- Friedberg, Iddo (1)
- Friedman, Justin (1)
- Friedrich, Torben (1)
- Frischholz., S. (1)
- Fritzenwanker, Moritz (1)
- Fruth, Angelika (1)
- Fröhlich, Kathrin (1)
- Fujisawa, Sho (1)
- Funk, Christopher S. (1)
- Förstner, Konrad U (1)
- Gabaldon, Toni (1)
- Gadeberg, Ole V. (1)
- Gadient, Sandra (1)
- Gadisa, Endalamaw (1)
- Gadkari, Jennifer (1)
- Gagneux, Sebastien (1)
- Garcia, E. G. (1)
- García-Betancur, Juan-Carlos (1)
- García-Gonzalo, Diego (1)
- Gbureck, Uwe (1)
- Gehrmann, Robin (1)
- Geier, Andreas (1)
- Geissinger, Ulrike (1)
- Gelfand, Mikhail S. (1)
- Gemovic, Branislava (1)
- Germer, Christoph-Thomas (1)
- Gerova, Milan (1)
- Gersemann, Michael (1)
- Gholami, Sepideh (1)
- Gholami, Spedideh (1)
- Giacca, Mauro (1)
- Gillis, Jesse (1)
- Ginter, Filip (1)
- Giollo, Manuel (1)
- Girard, Myriam (1)
- Glass, Mandy (1)
- Glennon, Jeffrey C. (1)
- Glisic, Sanja (1)
- Gnamlin, Prisca (1)
- Goebel, Melanie (1)
- Goerke, Christiane (1)
- Goldberg, Tatyana (1)
- Gomes, Sara F. Martins (1)
- Gong, Qingtian (1)
- Good, Liam (1)
- Gordon, Stephen V (1)
- Goris, Tobias (1)
- Gorski, Stanislaw A. (1)
- Gottschalk, Gerhard (1)
- Gough, Julian (1)
- Govindarajan, Sutharsan (1)
- Goñi-Moreno, Angel (1)
- Graham, David R. (1)
- Greene, Casey S. (1)
- Groeber-Becker, Florian (1)
- Gronberg-Hernandez, Jenny (1)
- Grozdanov, Lubomir Assenov (1)
- Grummt, Friedrich (1)
- Gräf, Ralph (1)
- Gucwa, Katarzyna (1)
- Gudi, Viktoria (1)
- Gulle, H. (1)
- Gumi, Balako (1)
- Guo-Liang, Chew (1)
- Gutmann, Marcus (1)
- Górna, Maria W. (1)
- Günzl, Arthur (1)
- Haas, Hubertus (1)
- Haas, Karina A. (1)
- Habermann, Bianca H. (1)
- Haberzettl, Kerstin (1)
- Habtamu, Meseret (1)
- Hacker, Joerg (1)
- Haddad, Dana (1)
- Hagmann [geb. Kischkies], Laura Violetta (1)
- Hahn, Julia (1)
- Hahnel, Mark J. (1)
- Hailu, Elena (1)
- Hakala, Kai (1)
- Hale, Christine (1)
- Hamdy, Aisha (1)
- Hammelmann, Matthias (1)
- Hammerschmidt, Stefan (1)
- Hammond, Ming C. (1)
- Hamp, Tobias (1)
- Hampe, Irene A. I. (1)
- Hampe, Irene Aurelia Ida (1)
- Handman, E. (1)
- Handman, Emanuela (1)
- Haneke, Katharina (1)
- Hanisch, F., G. (1)
- Hanisch, Franz-Georg (1)
- Hankir, Mohammed Khair (1)
- Hanzelmann, Dennis (1)
- Harcourt, Katherine (1)
- Harris, Simon R. (1)
- Hartmann, Thomas (1)
- Hassan, Musa A. (1)
- Hauck, Christof R. (1)
- Hauf, Laura (1)
- Hayward, Regan J. (1)
- Hazra, Banasri (1)
- Hazra, Banazri (1)
- Hecht, Nina (1)
- Hecker, Michael (1)
- Heesemann, Jürgen (1)
- Helal, Mustafa (1)
- Helbig, Jürgen H. (1)
- Helfer, Anne-Catherine (1)
- Henkel, W. (1)
- Hennessen, Fabienne (1)
- Hentschel, Ute (1)
- Hepp, Laura (1)
- Herbig, Alexander (1)
- Hermsen, Cornelus C. (1)
- Herrmann, Jennifer (1)
- Hershko-Shalev, Tal (1)
- Herzig, P. (1)
- Herzog, Gloria (1)
- Hesterkamp, Thomas (1)
- Hewinson, Glyn (1)
- Hickey, Scott F. (1)
- Hiemann, Rico (1)
- Hieta, Reija (1)
- Hilker, Rolf (1)
- Hill, Jennifer (1)
- Hill, Philip J. (1)
- Hochhut, Bianca (1)
- Hoekstra, W. (1)
- Hof, Herbert (1)
- Hoffmann, Jan (1)
- Hoffmann, Steve (1)
- Hoffmeier, Klaus (1)
- Hofmann, Franka (1)
- Hohensee, Susann (1)
- Holm, Liisa (1)
- Holthöfer, H (1)
- Horger, Thomas (1)
- Hoschützky, Heinz (1)
- Hose, Dirk (1)
- Hsu, Wen-Lian (1)
- Hua, Tong Hua (1)
- Hube, Bernhard (1)
- Huettel, Bruno (1)
- Huhle, Burkhard (1)
- Hull, R. (1)
- Huntley, Rachael P. (1)
- Hurd, Alexander (1)
- Hurdayal, Ramona (1)
- Hussein, Jemal (1)
- Höbartner, Claudia (1)
- Hör, Jens (1)
- Hörner, Michaela (1)
- Hünninger, Kerstin (1)
- Hüttel, Stephan (1)
- Imakaev, Maxim (1)
- Imirzalioglu, Can (1)
- Ip, Chi Wang (1)
- Jacob, Jobin J. (1)
- Jacobsen, Ilse D. (1)
- Jakob, Franz (1)
- Janga, Harshavardhan (1)
- Jann, Klaus (1)
- Jansen, Rolf (1)
- Jaschkowitz, Greta (1)
- Jeltsch, Albert (1)
- Jenniches, Laura (1)
- Jiang, Yuxiang (1)
- Johnson, Alexander D. (1)
- Johnson, Sarah (1)
- Jones, David T. (1)
- Jones, Nicola G. (1)
- Jongen, W. (1)
- Joo, Hwang-Soo (1)
- Josupeit, Rafael (1)
- Juarez, A. (1)
- Juarez, Antonio (1)
- Jun, Kyong-Hwa (1)
- Jundt, Franziska (1)
- Jurkowski, Tomasz (1)
- Kaewphan, Suwisa (1)
- Kahanda, Indika (1)
- Kahl, Günter (1)
- Kam, Kai Man (1)
- Kamaruzzaman, Nor Fadhilah (1)
- Kampf, Thomas (1)
- Kampik, Daniel (1)
- Kane, Leanne (1)
- Kansakar, Lakesh (1)
- Kapelski, Stephanie (1)
- Karch, Helge (1)
- Karl, Ann-Kathrin (1)
- Kasperkowitz, Amelie (1)
- Kathariou, Sophia (1)
- Kattimani, Yogita (1)
- Kaufer, Benedikt B. (1)
- Kaufmann, S. H. E. (1)
- Kawczyński, Marcin (1)
- Kayisoglu, Özge (1)
- Keane, Jacqueline A. (1)
- Keber, Ursula (1)
- Keller, Christian (1)
- Kessie, David (1)
- Kestler, H. (1)
- Khan, Ishita K. (1)
- Kieninger, Ann-Katrin (1)
- Kießling, Claudia (1)
- Kihara, Daisuke (1)
- Kilinc, Mehmet O. (1)
- Kim, Brandon J. (1)
- Kirner, Julius Arthur (1)
- Kiros, Teklu (1)
- Klein, Teresa (1)
- Klemm, Theresa (1)
- Kleta, Sylvia (1)
- Kloppot, Peggy (1)
- Knapp, Stefan (1)
- Kniemeyer, Olaf (1)
- Kober, Christina (1)
- Kobusch, Iris (1)
- Koch, Gudrun (1)
- Koch, Natalie (1)
- Kohi, Thomas A. (1)
- Kollewe, Christian (1)
- Konhäuser, Matthias (1)
- Konradt, Christoph (1)
- Konzer, Anne (1)
- Koo, Da Chen Emily (1)
- Kopf, Matthias (1)
- Kopp, Kathrin (1)
- Koprich, James B. (1)
- Korhonen, Timo (1)
- Korhonen, Timo K. (1)
- Koskinen, Patrik (1)
- Kovács, Ákos T. (1)
- Kraft, Beatrice (1)
- Krallmann-Wenzel, U. (1)
- Kramer, C. (1)
- Krammer, Tobias (1)
- Krause, Andreas (1)
- Krause, Eva M. (1)
- Kreft, B. (1)
- Krischke, Markus (1)
- Krishna, Sanjeev (1)
- Krishnan, Chandradekar (1)
- Krohn-Molt, Ines (1)
- Kromer, S. (1)
- Krug, Melanie (1)
- Krysciak, Dagmar (1)
- Krönke, Klaus-D. (1)
- Krüger, Marcus (1)
- Krüger, Thomas (1)
- Kubke, Fabiana (1)
- Kubke, M Fabiana (1)
- Kuhfuss, Juliane (1)
- Kuhn, Michael (1)
- Kuipers, Oskar P. (1)
- Kunin, Calvin M. (1)
- Kuric, Martin (1)
- Kurz, Florian (1)
- Kurzai, Oliver (1)
- Kusch, Harald (1)
- Kusters, R. (1)
- Kuttler, Christina (1)
- Kwan, Hoi Shan (1)
- Köck, Robin (1)
- Köhling, Paul (1)
- König, Fabian (1)
- König, W (1)
- Königsrainer, Malina (1)
- Lahouassa, Hichem (1)
- Lai, Alicia Sook-Wei (1)
- Lai, Erh-Min (1)
- Lammers, Lydia (1)
- Langridge, Gemma C. (1)
- Lankapalli, Aditya Kumar (1)
- Lardenoije, Roy (1)
- Lauer, Ulrich M. (1)
- Lavezzo, Enrico (1)
- Lavigne, Rob (1)
- Lavysh, Daria (1)
- Law, Patrick Tik Wan (1)
- Lawley, Trevor D. (1)
- Lawniczak, Mara (1)
- Lee, David (1)
- Lees, Jonathan G. (1)
- Legge, Duncan (1)
- LeibundGut-Landmann, Salome (1)
- Leimbach, Andreas (1)
- Lenz, Ann-Kathrin (1)
- Lepore, Rosalba (1)
- Lerch, Maike Franziska (1)
- Lesch, Klaus-Peter (1)
- Lethen, A. (1)
- Li, Biao (1)
- Liang, Chunguang (1)
- Liesegang, Heiko (1)
- Lima Prado Godinho, Joseane (1)
- Lin, Alexandra (1)
- Linde, Jörg (1)
- Lindgreen, Stinus (1)
- Linhardt, F. (1)
- Linial, Michal (1)
- Linnemann, Sabrina (1)
- Lioliou, Efthimia (1)
- Liou, Geoffrey (1)
- Liu, Quian (1)
- Liu, Wenting (1)
- Ljubimov, Nikolay (1)
- Lohse, Matthew B. (1)
- Loose, Maria (1)
- Looso, Mario (1)
- Lopez-Rubio, Jose-Juan (1)
- Loserth, Silke (1)
- Lou, Emil (1)
- Lovering, Ruth C. (1)
- Ludwig, Birgit (1)
- Ludwig, Stephan (1)
- Ludwig, Tobias (1)
- Lukežič, Tadeja (1)
- Lund, B. (1)
- López, Daniel (1)
- Lück, P. C. (1)
- Lück, P. Christian (1)
- Lühmann, Tessa (1)
- Maaß, Sandra (1)
- MacNeill, Amy (1)
- Macek, Boris (1)
- Magrane, Michele (1)
- Maichl, Daniela Simone (1)
- Maietta, Paolo (1)
- Makgotlho, Phuti E. (1)
- Makhotkina, Anastasiia (1)
- Makoah Nigel, Animake (1)
- Malfroot, Anne (1)
- Mamat, Uwe (1)
- Mank, Nils N. (1)
- Mann, K. H. (1)
- Marcet-Houben, Marina (1)
- Marchfelder, Anita (1)
- Marcu, Ana (1)
- Marget, M. (1)
- Margottin-Goguet, Florence (1)
- Marincola, Francesco M. (1)
- Marques, Sara (1)
- Marre, Reinhard (1)
- Martelli, Pier Luigi (1)
- Martin, Maria J. (1)
- Martin, Ronny (1)
- Martini, Rudolf (1)
- Martins, Rafeal M. (1)
- Martynow, Dorota (1)
- Masota, Nelson Enos (1)
- Matera, Gianluca (1)
- Maximov, Vladimir (1)
- Mayr, Eva-Maria (1)
- McConville, M. J. (1)
- McConville, Malcom J. (1)
- McFleder, Rhonda L. (1)
- McGimpsey, Stephanie (1)
- Mehling, Helene (1)
- Mehryary, Farrokh (1)
- Meissner, Markus (1)
- Mekonnen, Wondale (1)
- Melidoni, Anna N. (1)
- Mellmann, Alexander (1)
- Mengistu, Araya (1)
- Mesiti, Marco (1)
- Messner, P. (1)
- Methling, Karen (1)
- Metzner, Valentin (1)
- Mewis, Carolin (1)
- Michel, W. (1)
- Miethke, Marcus (1)
- Milewska, Maria J. (1)
- Milewski, Sławomir (1)
- Mills, Grant (1)
- Mineikaitė, Raminta (1)
- Minev, Boris R. (1)
- Minneci, Federico (1)
- Moch, Thomas (1)
- Mogavero, Floriana (1)
- Mogavero, Selene (1)
- Mojica, Kelly (1)
- Moldovan, Adriana (1)
- Monsieurs, Pieter (1)
- Mooney, Sean D. (1)
- Moreau, Yves (1)
- Moser, I. (1)
- Mottram, Jeremy C (1)
- Mottram, Jeremy C. (1)
- Mueller, Martin J. (1)
- Munoa, F. (1)
- Mutowo-Meullenet, Prudence (1)
- Mädler, Gohar (1)
- Mäurer, André Germar Paul (1)
- Möller, Philip (1)
- Müller, Anna A. (1)
- Müller, Christoph (1)
- Müller, Claudia Maria (1)
- Müller, Elke (1)
- Müller, Laura S. M. (1)
- Müller, Meike (1)
- Müller, Rolf (1)
- Müller, Sara (1)
- Müller, Sören (1)
- Müller, Tobias (1)
- Müller, Werner (1)
- Naddaf, Rawi (1)
- Nagy, Zoltan (1)
- Nahrendorf, Wiebke (1)
- Naumann, G. (1)
- Nellen, Wolfgang (1)
- Nepusz, Tamás (1)
- Nerz, G. (1)
- Nesterchuk, Mikhail V. (1)
- Neuhaus, Winfried (1)
- Neumann, Yvonne (1)
- Neurgaonkar, Priya (1)
- Nguyen, Minh Thu (1)
- Nguyen, Tu N. (1)
- Nickel, Lisa (1)
- Nieman, Stefan (1)
- Niemann, Silke (1)
- Nieuwenhuizen, Natalie E. (1)
- Niklas, Carolin (1)
- Ning, Wei (1)
- Nkwouano Ngongang, Vanesa (1)
- Nobis-Bosch, R. (1)
- Nolte, Ingo (1)
- Nong, Wenyan (1)
- Novikova, Maria (1)
- Nowrousian, Minou (1)
- Nyasinga, Justin (1)
- Nyffenegger-Jann, Naja J. (1)
- Näther-Schindler, Daniela (1)
- O'Donovan, Claire (1)
- Oates, Matt (1)
- Odenheimer-Bergman, Ahuva (1)
- Ofer, Dan (1)
- Okoro, Chinyere K. (1)
- Okuda, Takumi (1)
- Omasits, Ulrich (1)
- Opferkuch, W. (1)
- Orengo, Christine A. (1)
- Oron, Tal Ronnen (1)
- Orskov, F. (1)
- Orskov, Ida (1)
- Osterman, Ilya A. (1)
- Oswald, Felix (1)
- Oswald, Sibylle (1)
- Othman, Eman M. (1)
- Ott, M (1)
- Otto, Michael (1)
- Ougeda, B. (1)
- Paccanaro, Alberto (1)
- Paetzold, Susanne (1)
- Page, Andrew J. (1)
- Pagenstecher, Axel (1)
- Pagán, Rafael (1)
- Palige, Katja (1)
- Palme, Rupert (1)
- Park, Sung Hee (1)
- Parkkinen, Jaakko (1)
- Pasparakis, Manolis (1)
- Patrick, Wayne M. (1)
- Pavlidis, Paul (1)
- Pawelzik, M. (1)
- Pena-Miller, Rafael (1)
- Penev, Lyubomir (1)
- Penfold-Brown, Duncan (1)
- Perovic, Vladmir (1)
- Peschel, Andreas (1)
- Pessi, Gabriella (1)
- Peteranderl, Alina (1)
- Peters, Georg (1)
- Petković, Hrvoje (1)
- Peña Mosca, Josefina (1)
- Pfeffer, K. (1)
- Pfeiffer, Friedhelm (1)
- Pfeiffer, Verena (1)
- Pichler, Klemens (1)
- Pickard, Derek J. (1)
- Pils, Stefan (1)
- Pinsky, Mariel (1)
- Piovesan, Damiano (1)
- Planz, Oliver (1)
- Plogmann, Ricarda (1)
- Politano, Gianfranco (1)
- Ponath, Falk Fred Finn (1)
- Poole, Anthony M. (1)
- Popp, Sandy (1)
- Potempa, Jan (1)
- Prester, M. (1)
- Prezza, Gianluca (1)
- Prieto, Judith H. (1)
- Print, Cristin G. (1)
- Profiti, Giuseppe (1)
- Przyborski, Jude M. (1)
- Pérez, J. Christian (1)
- Qin, Qian (1)
- Quail, Michael A. (1)
- Raab, Viktoria (1)
- Radivojac, Predrag (1)
- Ragnarsdottir, Bryndis (1)
- Rain, Jean-Christopher (1)
- Rakette, Sonja (1)
- Ramachandran, Vinoy K. (1)
- Ramirez Pineda, José Robinson (1)
- Ramirez, Bertha Cécilia (1)
- Ramírez‐Zavala, Bernardo (1)
- Rappersberger, Klemens (1)
- Rappoport, Nadav (1)
- Raschig, Martina (1)
- Rdest, Ursula (1)
- Re, Matteo (1)
- Read, Hannah M. (1)
- Reeve, John N. (1)
- Rehman, Hafeez Ur (1)
- Reichardt, Sarah (1)
- Reichert, Sebstian (1)
- Remer, Katharina A. (1)
- Remes, Bernhard (1)
- Remmele, Christian W. (1)
- Reuscher, Carina M (1)
- Reuter, Christian (1)
- Reuter, Saskia (1)
- Reuter-Weissenberger, Philipp (1)
- Revathi, Gunturu (1)
- Reynolds, David (1)
- Rhen, M. (1)
- Richter, Andreas S. (1)
- Richter, Lothar (1)
- Riegmann, N. (1)
- Rios-Miguel, Ana B. (1)
- Rische, Tom (1)
- Robbe-Saule, Marie (1)
- Roberts, A. (1)
- Robertson, Brian D (1)
- Robinson, Peter N. (1)
- Rodriguez, Hector (1)
- Rodriguez, Héctor (1)
- Roers, Axel (1)
- Rogers, David P. (1)
- Romby, Pascale (1)
- Romero, Alfonso E. (1)
- Ron, Eliora Z. (1)
- Rosenwald, Andreas (1)
- Rost, Burkhard (1)
- Rotter, Björn (1)
- Rudolph, Stephan (1)
- Rupp, Steffen (1)
- Ryan, Daniel (1)
- Röger, Bianca (1)
- Röhrich, Christian Rene (1)
- Röllinghoff, M. (1)
- Sabatini, Robert (1)
- Saedtler, Marco (1)
- Sahraeian, Sayed M. E. (1)
- Said, Nelly (1)
- Salakoski, Tapio (1)
- Salamov, Asaf (1)
- Santamaria, Jorge (1)
- Santamaria, Ramon I. (1)
- Santamaría, Ramón I. (1)
- Santangelo, Thomas J. (1)
- Santos, Sara C. (1)
- Sanyal, Anirban (1)
- Sasidharan, Rajkumar (1)
- Sass, Andrea M. (1)
- Sasse, Christoph (1)
- Sauerwein, Robert W. (1)
- Sauerwein, Till (1)
- Savino, Alessandro (1)
- Scadeng, Miriam (1)
- Schafferer, Lukas (1)
- Schaible, Ulrich E. (1)
- Scheidig-Benatar, Christine (1)
- Schelling, Esther (1)
- Scherf, Artur (1)
- Schielmann, Marta (1)
- Schierack, Peter (1)
- Schiller, Roswitha (1)
- Schillig, Rebecca (1)
- Schinkel, Helga (1)
- Schirmeister, Tanja (1)
- Schirrmacher, Volker (1)
- Schittek, Birgit (1)
- Schlegel, Nicolas (1)
- Schmaler, Mathias (1)
- Schmeisser, Christel (1)
- Schmid, A. (1)
- Schmidt, G (1)
- Schmidt, M. Alexander (1)
- Schmidtberg, Henrike (1)
- Schmidtke, Cornelius (1)
- Schmiedel, Judith (1)
- Schmitt, Susanne (1)
- Schmitt-Böhrer, Angelika (1)
- Schmitt-Böhrer, Angelika G. (1)
- Schmittroth, M. (1)
- Schneider, Cornelius (1)
- Schneider, Sabrina (1)
- Schnitzer, Johannes K. (1)
- Schoel, H. (1)
- Schollenbruch, Hannah (1)
- Schollmayer, Curd (1)
- Scholz, Claus Jürgen (1)
- Schott, Melanie (1)
- Schrenzel, Jacques (1)
- Schrettenbrunner, A. (1)
- Schroten, Horst (1)
- Schröter, G. (1)
- Schubert, Torsten (1)
- Schubert-Unkmeir, Alexandra (1)
- Schuelein-Voelk, Christina (1)
- Schultz, Daniel (1)
- Schwarz, Tobias (1)
- Schwarzer, Dirk (1)
- Schäfer, Daniel (1)
- Scollay, R. (1)
- Scollay, Roland (1)
- Seckinger, Anja (1)
- Sedeño-Cortés, Adriana E. (1)
- Seitz, Florian (1)
- Selle, Martina (1)
- Semmler, Torsten (1)
- Sen, Rituparno (1)
- Seo, Ean Jeong (1)
- Sergiev, Petr V. (1)
- Seri, Hemda (1)
- Shannon-Lowe, Claire (1)
- Sharma, Cynthia M (1)
- Shasha, Dennis (1)
- Shearer, Neil (1)
- Shusta, Eric V. (1)
- Shypitsyna, Aleksandra (1)
- Siewe, Lisa (1)
- Silkenat, Sabrina (1)
- Sillitoe, Ian (1)
- Silva, Ricardo Jorge (1)
- Simon, Nina (1)
- Simon, Nina Monica (1)
- Simons, Mikael (1)
- Sinden, Robert E. (1)
- Sinha, Bhanu (1)
- Sismeiro, Odile (1)
- Skunca, Nives (1)
- Slashcheva, Marina (1)
- Smithers, Ben (1)
- Soinila, S. (1)
- Sokolova, Maria (1)
- Sokolowska-Köhler, W. (1)
- Song, Tae-Jin (1)
- Soppa, Jörg (1)
- Soundararajan, Manonmani (1)
- Sourisce, Adèle (1)
- Spehr, Marc (1)
- Sridhar, Malathy (1)
- Sroka, Aneta (1)
- Stadler, Marc (1)
- Stadler, Peter F. (1)
- Staedel, Cathy (1)
- Stahl, Mark (1)
- Staib, Claudia (1)
- Staib, Peter (1)
- Stange, Eduard F. (1)
- Stangel, Martin (1)
- Stanway, Rebecca S. (1)
- Steger, Mirco (1)
- Stehle, Thilo (1)
- Steinbusch, Harry W. M. (1)
- Steinig, M. (1)
- Stelzner, Kathrin (1)
- Stentzel, Sebastian (1)
- Stern, Amos (1)
- Stevanovic, Stefan (1)
- Stevens, Mark P. (1)
- Stopper, Helga (1)
- Streit, Wolfgang R. (1)
- Strekalova, Tatyana (1)
- Sturm, Julia (1)
- Sturm, Volker Jörg Friedrich (1)
- Sullivan, Derek J. (1)
- Sunkavalli, Ushasree (1)
- Supek, Fran (1)
- Surendranath, Vineeth (1)
- Suzuki, Brian M. (1)
- Svanborg, Catharina (1)
- Szalay, Aladar A (1)
- Szijártó, Valeria (1)
- Szweda, Piotr (1)
- Tabuchi, Sawako (1)
- Talman, Arthur M. (1)
- Tarr, Phillip I. (1)
- Tascon, Julia Delgado (1)
- Tedin, Karsten (1)
- Tenzer, Stefan (1)
- Thamm, Douglas (1)
- Thapa, Prithivi Jung (1)
- Then, I. (1)
- Then, Irene (1)
- Thom, Pascal (1)
- Thompson, Arthur (1)
- Thomson, Nick R. (1)
- Tian, Weidong (1)
- Tikhonov, Anton (1)
- Tint, Su Hlaing (1)
- Tiu, W. U. (1)
- Toppo, Stefano (1)
- Torsin, Sanda (1)
- Tosatto, Silvio C. E. (1)
- Tramontano, Anna (1)
- Tranchevent, Léon-Charles (1)
- Tress, Michael L. (1)
- Trujillo Vargas, Claudia Milena (1)
- Tsai, Peter (1)
- Tschopp, Rea (1)
- Törönen, Petri (1)
- Ubaida-Mohien, Ceereena (1)
- Uhlenbruck, G. (1)
- Uhlenbrück, Gerhard (1)
- Uhlin, B. E. (1)
- Uhlin, Bernt Eric (1)
- Ulbricht, Andrea (1)
- Ulmer, E. (1)
- Umu, Sinan Uğur (1)
- Vafadarnejad, Ehsan (1)
- Valencia Hernandez, Ana Maria (1)
- Valencia, Alfonso (1)
- Valentini, Giorgio (1)
- Van Acker, Heleen (1)
- Van Arsdale-White, Laura (1)
- Van Bergen en Henegouwen, P. (1)
- Van Houdt, Rob (1)
- Van Nieuwerburgh, Filip (1)
- Van Veggel, H. (1)
- Vandenesch, François (1)
- Varadarajulu, Jeeva (1)
- Vargas Gebauer, Herman (1)
- Vasquez, Juan J. (1)
- Veljkovic, Nevena (1)
- Veljkovic, Veljko (1)
- Vembar, Shruti S. (1)
- Vencio, Ricardo Z. N. (1)
- Ventur, Y. (1)
- Verbree, Carolin (1)
- Verspoor, Karin M. (1)
- Vetter, Viktoria (1)
- Vijayendra, Pooja (1)
- Vilcinskas, Andreas (1)
- Villaveces, Jose M. (1)
- Vladu, Adrian V. (1)
- Voepel, Nadja (1)
- Vogg, Gerd (1)
- Voigt, Birgit (1)
- Volkmann, Jens (1)
- Volkmer, Michael (1)
- Voss, Bjoern (1)
- Vucetic, Slobodan (1)
- Wagenlehner, Florian (1)
- Wagner, H. (1)
- Wagner, Ines (1)
- Wagner, Rabea M. (1)
- Wagner, Wilma (1)
- Wahn, V (1)
- Wahn, Volker (1)
- Waider, Jonas (1)
- Waldchen, Sina (1)
- Walther, Birgit (1)
- Wang, Ena (1)
- Wang, Huiqiang (1)
- Wang, Zheng (1)
- Wasserman, Elizabeth (1)
- Weber, Heike (1)
- Weber, Johann (1)
- Weber, Lennart (1)
- Wecklein, Björn (1)
- Wehkamp, Jan (1)
- Weidenbach, Katrin (1)
- Weidner, Magdalena T. (1)
- Weissman, Ziva (1)
- Wels, W. (1)
- Wen, Tuan-Nan (1)
- Wencker, Freya D. R (1)
- Wencker, Freya D.R. (1)
- Wencker, Freya Dorothea Ruth (1)
- Werner, Julia (1)
- Wich, Peter R. (1)
- Wicke, Laura (1)
- Wiegering, Armin (1)
- Wieler, Lothar H. (1)
- Wiesner, Jochen (1)
- Wiest, Johannes (1)
- Wight, Darren J. (1)
- Wiles, Siouxsie (1)
- Williams, Roderick AM (1)
- Wilms, Ina (1)
- Windhof, Indra M. (1)
- Wingeder, J. (1)
- Winter, Peter (1)
- Wintermeyer, Eva (1)
- Witte, W. (1)
- Wittig, Walter (1)
- Wohlmuth, Barbara (1)
- Wolf, Katharina (1)
- Wolf, Silver A. (1)
- Wollner, Andreas (1)
- Wolske, Anja (1)
- Wolz, Christine (1)
- Wong, Hin-chung (1)
- Wood, G. (1)
- Worschech, Andrea (1)
- Wu, Jingjing (1)
- Wu, Rongxue (1)
- Wu, Xiao-Qin (1)
- Wullaert, Andy (1)
- Wullt, Bjorn (1)
- Xu, Tao (1)
- Xu, Zhuofei (1)
- Yagci, Seray (1)
- Yamuah, Lawrence (1)
- Yang, Haixuan (1)
- Yasrebi, Kaveh (1)
- Yates, John R., III (1)
- Ye, Yuxiang (1)
- Ymeraj, Alba (1)
- Youngs, Noah (1)
- Yu, Wenqi (1)
- Zabel, Susanne (1)
- Zaburannyi, Nestor (1)
- Zakeri, Pooya (1)
- Zanzonico, Pat (1)
- Zanzonico, Pat B. (1)
- Zdziarski, Jaroslaw (1)
- Zdziarski, Jaroslaw Maciej (1)
- Zdzieblo, Daniela (1)
- Zerlin, Leah (1)
- Zernecke, Alma (1)
- Zhang, Qinfeng (1)
- Zhang, Shanshan (1)
- Zhong, Zhaolong (1)
- Zhou, Yuanpeng (1)
- Ziebuhr, W. (1)
- Zimmermann, Martina (1)
- Zinsstag, Jakob (1)
- Zukher, Inna (1)
- de Guibert, Julio Grimm (1)
- de Oliveira Almeida Petersen, Antonio Luis (1)
- del Pozo, Angela (1)
- van Dijk, Aalt D. J. (1)
- van den Hove, Daniel L. A. (1)
- von Bohl, Andreas (1)
- Özge, Kayisoglu (1)
- Čuklina, Jelena (1)
Institute
- Institut für Molekulare Infektionsbiologie (346) (remove)
Sonstige beteiligte Institutionen
- Genelux Corporation, San Diego Science Center, 3030 Bunker Hill Street, Suite 310, San Diego, California 92109, USA (1)
- Helmholtz Center for RNA-based Infection Research (1)
- Institut für Molekulare Infektionsbiologie (MIB) der Universität Würzburg (1)
- MRB Forschungszentrum für Magnet-Resonanz-Bayern e.V., Am Hubland, D-97074 Würzburg (1)
- Research Center for Infectious Diseases (ZINF), University of Wuerzburg, Wuerzburg, Germany, (1)
- Research Center of Infectious Diseases (ZINF) of the University of Wurzburg, Germany (1)
- Universitätsklinikum Münster (1)
- Zentrum für Infektionsforschung (ZINF): Nachwuchsgruppe 2 (1)
Jun, Kyong-Hwa ; Gholami, Spedideh ; Song, Tae-Jin ; Au, Joyce ; Haddad, Dana ; Carson, Joshua ; Chen, Chun-Hao ; Mojica, Kelly ; Zanzonico, Pat ; Chen, Nanhai G. ; Zhang, Qian ; Szalay, Aladar ; Fong, Yuman
Background: Gastric cancers have poor overall survival despite recent advancements in early detection methods, endoscopic resection techniques, and chemotherapy treatments. Vaccinia viral therapy has had promising therapeutic potential for various cancers and has a great safety profile. We investigated the therapeutic efficacy of a novel genetically-engineered vaccinia virus carrying the human sodium iodide symporter (hNIS) gene, GLV-1 h153, on gastric cancers and its potential utility for imaging with Tc-99m pertechnetate scintigraphy and I-124 positron emission tomography (PET).
Methods: GLV-1 h153 was tested against five human gastric cancer cell lines using cytotoxicity and standard viral plaque assays. In vivo, subcutaneous flank tumors were generated in nude mice with human gastric cancer cells, MKN-74. Tumors were subsequently injected with either GLV-1 h153 or PBS and followed for tumor growth. Tc-99m pertechnetate scintigraphy and I-124 microPET imaging were performed.
Results: GFP expression, a surrogate for viral infectivity, confirmed viral infection by 24 hours. At a multiplicity of infection (MOI) of 1, GLV-1 h153 achieved > 90% cytotoxicity in MNK-74, OCUM-2MD3, and AGS over 9 days, and >70% cytotoxicity in MNK-45 and TMK-1. In vivo, GLV-1 h153 was effective in treating xenografts (p < 0.001) after 2 weeks of treatment. GLV-1 h153-infected tumors were readily imaged by Tc-99m pertechnetate scintigraphy and I-124 microPET imaging 2 days after treatment.
Conclusions: GLV-1 h153 is an effective oncolytic virus expressing the hNIS protein that can efficiently regress gastric tumors and allow deep-tissue imaging. These data encourages its continued investigation in clinical settings.
The Gram-negative rod-shaped bacterium Pseudomonas aeruginosa is not only a major cause of nosocomial infections but also serves as a model species of bacterial RNA biology. While its transcriptome architecture and posttranscriptional regulation through the RNA-binding proteins Hfq, RsmA, and RsmN have been studied in detail, global information about stable RNA-protein complexes in this human pathogen is currently lacking. Here, we implement gradient profiling by sequencing (Grad-seq) in exponentially growing P. aeruginosa cells to comprehensively predict RNA and protein complexes, based on glycerol gradient sedimentation profiles of >73% of all transcripts and ∼40% of all proteins. As to benchmarking, our global profiles readily reported complexes of stable RNAs of P. aeruginosa, including 6S RNA with RNA polymerase and associated product RNAs (pRNAs). We observe specific clusters of noncoding RNAs, which correlate with Hfq and RsmA/N, and provide a first hint that P. aeruginosa expresses a ProQ-like FinO domain-containing RNA-binding protein. To understand how biological stress may perturb cellular RNA/protein complexes, we performed Grad-seq after infection by the bacteriophage ΦKZ. This model phage, which has a well-defined transcription profile during host takeover, displayed efficient translational utilization of phage mRNAs and tRNAs, as evident from their increased cosedimentation with ribosomal subunits. Additionally, Grad-seq experimentally determines previously overlooked phage-encoded noncoding RNAs. Taken together, the Pseudomonas protein and RNA complex data provided here will pave the way to a better understanding of RNA-protein interactions during viral predation of the bacterial cell.
IMPORTANCE Stable complexes by cellular proteins and RNA molecules lie at the heart of gene regulation and physiology in any bacterium of interest. It is therefore crucial to globally determine these complexes in order to identify and characterize new molecular players and regulation mechanisms. Pseudomonads harbor some of the largest genomes known in bacteria, encoding ∼5,500 different proteins. Here, we provide a first glimpse on which proteins and cellular transcripts form stable complexes in the human pathogen Pseudomonas aeruginosa. We additionally performed this analysis with bacteria subjected to the important and frequently encountered biological stress of a bacteriophage infection. We identified several molecules with established roles in a variety of cellular pathways, which were affected by the phage and can now be explored for their role during phage infection. Most importantly, we observed strong colocalization of phage transcripts and host ribosomes, indicating the existence of specialized translation mechanisms during phage infection. All data are publicly available in an interactive and easy to use browser.
Bar-Yosef, Hagit ; Gildor, Tsvia ; Ramírez-Zavala, Bernardo ; Schmauch, Christian ; Weissman, Ziva ; Pinsky, Mariel ; Naddaf, Rawi ; Morschhäuser, Joachim ; Arkowitz, Robert A. ; Kornitzer, Daniel
The human pathogenic fungus Candida albicans can switch between yeast and hyphal morphologies as a function of environmental conditions and cellular physiology. The yeast-to-hyphae morphogenetic switch is activated by well-established, kinase-based signal transduction pathways that are induced by extracellular stimuli. In order to identify possible inhibitory pathways of the yeast-to-hyphae transition, we interrogated a collection of C. albicans protein kinases and phosphatases ectopically expressed under the regulation of the TETon promoter. Proportionately more phosphatases than kinases were identified that inhibited hyphal morphogenesis, consistent with the known role of protein phosphorylation in hyphal induction. Among the kinases, we identified AKL1 as a gene that significantly suppressed hyphal morphogenesis in serum. Akl1 specifically affected hyphal elongation rather than initiation: overexpression of AKL1 repressed hyphal growth, and deletion of AKL1 resulted in acceleration of the rate of hyphal elongation. Akl1 suppressed fluid-phase endocytosis, probably via Pan1, a putative clathrin-mediated endocytosis scaffolding protein. In the absence of Akl1, the Pan1 patches were delocalized from the sub-apical region, and fluid-phase endocytosis was intensified. These results underscore the requirement of an active endocytic pathway for hyphal morphogenesis. Furthermore, these results suggest that under standard conditions, endocytosis is rate-limiting for hyphal elongation.
A remarkable feature of many small non-coding RNAs (sRNAs) of Escherichia coli and Salmonella is their accumulation in the stationary phase of bacterial growth. Several stress response regulators and sigma factors have been reported to direct the transcription of stationary phase-specific sRNAs, but a widely conserved sRNA gene that is controlled by the major stationary phase and stress sigma factor, Sigma(S) (RpoS), has remained elusive. We have studied in Salmonella the conserved SdsR sRNA, previously known as RyeB, one of the most abundant stationary phase-specific sRNAs in E. coli. Alignments of the sdsR promoter region and genetic analysis strongly suggest that this sRNA gene is selectively transcribed by Sigma(S). We show that SdsR down-regulates the synthesis of the major Salmonella porin OmpD by Hfq-dependent base pairing; SdsR thus represents the fourth sRNA to regulate this major outer membrane porin. Similar to the InvR, MicC and RybB sRNAs, SdsR recognizes the ompD mRNA in the coding sequence, suggesting that this mRNA may be primarily targeted downstream of the start codon. The SdsR-binding site in ompD was localized by 3'-RACE, an experimental approach that promises to be of use in predicting other sRNA-target interactions in bacteria.
A Candidate Approach Implicates the Secreted Salmonella Effector Protein SpvB in P-Body Disassembly
(2011)
P-bodies are dynamic aggregates of RNA and proteins involved in several post-transcriptional regulation processes. Pbodies have been shown to play important roles in regulating viral infection, whereas their interplay with bacterial pathogens, specifically intracellular bacteria that extensively manipulate host cell pathways, remains unknown. Here, we report that Salmonella infection induces P-body disassembly in a cell type-specific manner, and independently of previously characterized pathways such as inhibition of host cell RNA synthesis or microRNA-mediated gene silencing. We show that the Salmonella-induced P-body disassembly depends on the activation of the SPI-2 encoded type 3 secretion system, and that the secreted effector protein SpvB plays a major role in this process. P-body disruption is also induced by the related pathogen, Shigella flexneri, arguing that this might be a new mechanism by which intracellular bacterial pathogens subvert host cell function.
Background
The emergence of antibiotic resistant bacteria in recent decades has highlighted the importance of developing new drugs to treat infections. However, in addition to the design of new drugs, the development of accurate preclinical testing methods is essential. In vivo imaging technologies such as bioluminescence imaging (BLI) or magnetic resonance imaging (MRI) are promising approaches. In a previous study, we showed the effectiveness of \(^{19}\)F MRI using perfluorocarbon (PFC) emulsions for detecting the site of Staphylococcus aureus infection. In the present follow-up study, we investigated the use of this method for in vivo visualization of the effects of antibiotic therapy.
Methods/Principal findings
Mice were infected with S. aureus Xen29 and treated with 0.9% NaCl solution, vancomycin or linezolid. Mock treatment led to the highest bioluminescence values during infection followed by vancomycin treatment. Counting the number of colony-forming units (cfu) at 7 days post-infection (p.i.) showed the highest bacterial burden for the mock group and the lowest for the linezolid group. Administration of PFCs at day 2 p.i. led to the accumulation of \(^{19}\)F at the rim of the abscess in all mice (in the shape of a hollow sphere), and antibiotic treatment decreased the \(^{19}\)F signal intensity and volume. Linezolid showed the strongest effect. The BLI, cfu, and MRI results were comparable.
Conclusions
\(^{19}\)F-MRI with PFCs is an effective non-invasive method for assessing the effects of antibiotic therapy in vivo. This method does not depend on pathogen specific markers and can therefore be used to estimate the efficacy of antibacterial therapy against a broad range of clinically relevant pathogens, and to localize sites of infection.