Refine
Has Fulltext
- yes (646)
Year of publication
- 2020 (646) (remove)
Document Type
- Journal article (646) (remove)
Language
- English (610)
- German (34)
- French (1)
- Multiple languages (1)
Keywords
- boron (9)
- multiple myeloma (9)
- machine learning (8)
- COVID-19 (7)
- autophagy (6)
- biodiversity (6)
- cancer (6)
- depression (6)
- inflammation (6)
- toxicity (6)
Institute
- Theodor-Boveri-Institut für Biowissenschaften (99)
- Medizinische Klinik und Poliklinik II (45)
- Institut für Anorganische Chemie (38)
- Neurologische Klinik und Poliklinik (32)
- Institut für Organische Chemie (29)
- Klinik und Poliklinik für Anästhesiologie (ab 2004) (26)
- Institut für Geographie und Geologie (23)
- Institut für Psychologie (23)
- Institut für Klinische Epidemiologie und Biometrie (22)
- Klinik und Poliklinik für Dermatologie, Venerologie und Allergologie (22)
- Lehrstuhl für Orthopädie (22)
- Institut für diagnostische und interventionelle Radiologie (Institut für Röntgendiagnostik) (21)
- Medizinische Klinik und Poliklinik I (21)
- Deutsches Zentrum für Herzinsuffizienz (DZHI) (20)
- Klinik und Poliklinik für Nuklearmedizin (19)
- Abteilung für Funktionswerkstoffe der Medizin und der Zahnheilkunde (16)
- Institut für Informatik (15)
- Klinik und Poliklinik für Allgemein-, Viszeral-, Gefäß- und Kinderchirurgie (Chirurgische Klinik I) (15)
- Klinik und Poliklinik für Psychiatrie, Psychosomatik und Psychotherapie (15)
- Lehrstuhl für Tissue Engineering und Regenerative Medizin (15)
- Institut für Pharmazie und Lebensmittelchemie (14)
- Rudolf-Virchow-Zentrum (14)
- Institut für Anatomie und Zellbiologie (13)
- Institut für Molekulare Infektionsbiologie (13)
- Julius-von-Sachs-Institut für Biowissenschaften (13)
- Kinderklinik und Poliklinik (13)
- Pathologisches Institut (13)
- Institut für Pharmakologie und Toxikologie (12)
- Klinik und Poliklinik für Unfall-, Hand-, Plastische und Wiederherstellungschirurgie (Chirurgische Klinik II) (12)
- Institut für Humangenetik (11)
- Institut für Physikalische und Theoretische Chemie (11)
- Institut für Hygiene und Mikrobiologie (10)
- Institut für Experimentelle Biomedizin (9)
- Institut für Mathematik (9)
- Institut für diagnostische und interventionelle Neuroradiologie (ehem. Abteilung für Neuroradiologie) (9)
- Neuphilologisches Institut - Moderne Fremdsprachen (9)
- Physikalisches Institut (9)
- Institut für Virologie und Immunbiologie (8)
- Klinik und Poliklinik für Kinder- und Jugendpsychiatrie, Psychosomatik und Psychotherapie (8)
- Institut für Klinische Neurobiologie (7)
- Institut für Theoretische Physik und Astrophysik (7)
- Klinik und Poliklinik für Strahlentherapie (7)
- Neurochirurgische Klinik und Poliklinik (7)
- Center for Computational and Theoretical Biology (6)
- Institut für Sportwissenschaft (6)
- Poliklinik für Zahnärztliche Prothetik (6)
- Frauenklinik und Poliklinik (5)
- Comprehensive Cancer Center Mainfranken (4)
- Institut für Allgemeinmedizin (4)
- Institut für Pädagogik (4)
- Institut für Rechtsmedizin (4)
- Urologische Klinik und Poliklinik (4)
- Abteilung für Parodontologie (in der Poliklinik für Zahnerhaltung und Parodontologie) (3)
- Institut für Funktionsmaterialien und Biofabrikation (3)
- Institut für Psychotherapie und Medizinische Psychologie (3)
- Klinik und Poliklinik für Hals-, Nasen- und Ohrenkrankheiten, plastische und ästhetische Operationen (3)
- Medizinische Fakultät (3)
- Physiologisches Institut (3)
- Sportzentrum (3)
- Augenklinik und Poliklinik (2)
- Institut Mensch - Computer - Medien (2)
- Institut für Klinische Biochemie und Pathobiochemie (2)
- Institut für Politikwissenschaft und Soziologie (2)
- Institut für deutsche Philologie (2)
- Klinik und Poliklinik für Mund-, Kiefer- und Plastische Gesichtschirurgie (2)
- Lehrstuhl für Biochemie (2)
- Lehrstuhl für Molekulare Psychiatrie (2)
- Poliklinik für Zahnerhaltung und Parodontologie (2)
- Universitätsbibliothek (2)
- Abteilung für Molekulare Innere Medizin (in der Medizinischen Klinik und Poliklinik II) (1)
- Betriebswirtschaftliches Institut (1)
- Fakultät für Physik und Astronomie (1)
- Graduate School of Life Sciences (1)
- Institut für Altertumswissenschaften (1)
- Institut für Geschichte der Medizin (1)
- Institut für Klinische Transfusionsmedizin und Hämotherapie (1)
- Institut für Medizinische Lehre und Ausbildungsforschung (1)
- Institut für Medizinische Strahlenkunde und Zellforschung (1)
- Institut für Philosophie (1)
- Institut für Praktische Theologie (1)
- Institut für Systemimmunologie (1)
- Katholisch-Theologische Fakultät (1)
- Poliklinik für Kieferorthopädie (1)
Sonstige beteiligte Institutionen
- Agricultural Center, BASF SE, 67117 Limburgerhof, Germany (1)
- Core Unit Systemmedizin (1)
- Institute of Organic Chemistry and Center for Molecular Biosciences Innsbruck, CMBI, Leopold-Franzens University Innsbruck, Austria (1)
- Interdisciplinary Center for Clinical Research (1)
- Mildred Scheel Early Career Center (1)
- Paul Scherrer Institut (1)
Plants may use different strategies to attract pollinators in long distance (e.g. floral display) and in short distance (e.g. ratio between differentially colored flowers) scales. The Verbenaceae Lantana canescens Kunth is a wide spread species in open sites of the Brazilian Pantanal wetland. Individuals of this generalist species can produce a variable number of open inflorescences with yellow and white flowers that are organized in whorls. In this study we tested the hypothesis that increased floral display (long distance attraction) and the ratio between yellow and white flowers (short distance attraction) enhances the number of pollinator species and individuals. We observed flower visitors and calculated floral parameters in 38 plots of 1 m2 each, that contained a varying number of flowering L. canescens individuals. Non-metric multidimensional scaling and Bray-Curtis distances were used to account for flower visitor composition and the relative visitation rate, respectively. We used a structural equation model to test the power of each predictor variable on the visitation rate and a covariance analysis to disentangle the effect of each independent variable on the frequency of plant-pollinator interactions. We found that the number of flower visitors and the visitation rate increased with increasing number of inflorescences. Disentangling long and short distance attraction indicated that the number of inflorescences (per plot) and the number of yellow flowers (yellowing effect) contributed most to flower visitation at long and short distance, respectively.
The carbohydrate D-glucose is the main source of energy in living organisms. In contrast to animals, as well as most fungi, bacteria, and archaea, plants are capable to synthesize a surplus of sugars characterizing them as autothrophic organisms. Thus, plants are de facto the source of all food on earth, either directly or indirectly via feed to livestock. Glucose is stored as polymeric glucan, in animals as glycogen and in plants as starch. Despite serving a general source for metabolic energy and energy storage, glucose is the main building block for cellulose synthesis and represents the metabolic starting point of carboxylate- and amino acid synthesis. Finally yet importantly, glucose functions as signalling molecule conveying the plant metabolic status for adjustment of growth, development, and survival. Therefore, cell-to-cell and long-distance transport of photoassimilates/sugars throughout the plant body require the fine-tuned activity of sugar transporters facilitating the transport across membranes. The functional plant counterparts of the animal sodium/glucose transporters (SGLTs) are represented by the proton-coupled sugar transport proteins (STPs) of the plant monosaccharide transporter(-like) family (MST). In the framework of this special issue on “Glucose Transporters in Health and Disease,” this review gives an overview of the function and structure of plant STPs in comparison to the respective knowledge obtained with the animal Na+-coupled glucose transporters (SGLTs).
While there is abounding literature on virus-induced pathology in general and coronavirus in particular, recent evidence accumulates showing distinct and deleterious brain affection. As the respiratory tract connects to the brain without protection of the blood–brain barrier, SARS-CoV-2 might in the early invasive phase attack the cardiorespiratory centres located in the medulla/pons areas, giving rise to disturbances of respiration and cardiac problems. Furthermore, brainstem regions are at risk to lose their functional integrity. Therefore, long-term neurological as well as psychiatric symptomatology and eventual respective disorders cannot be excluded as evidenced from influenza-A triggered post-encephalitic Parkinsonism and HIV-1 triggered AIDS–dementia complex. From the available evidences for coronavirus-induced brain pathology, this review concludes a number of unmet needs for further research strategies like human postmortem brain analyses. SARS-CoV-2 mirroring experimental animal brain studies, characterization of time-dependent and region-dependent spreading behaviours of coronaviruses, enlightening of pathological mechanisms after coronavirus infection using long-term animal models and clinical observations of patients having had COVID-19 infection are calling to develop both protective strategies and drug discoveries to avoid early and late coronavirus-induced functional brain disturbances, symptoms and eventually disorders. To fight SARS-CoV-2, it is an urgent need to enforce clinical, molecular biological, neurochemical and genetic research including brain-related studies on a worldwide harmonized basis.
Giant cell arteritis (GCA) may affect the brain-supplying arteries, resulting in ischemic stroke, whereby the vertebrobasilar territory is most often involved. Since etiology is unknown in 25% of stroke patients and GCA is hardly considered as a cause, we examined in a pilot study, whether screening for GCA after vertebrobasilar stroke might unmask an otherwise missed disease. Consecutive patients with vertebrobasilar stroke were prospectively screened for GCA using erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), hemoglobin, and halo sign of the temporal and vertebral artery on ultrasound. Furthermore, we conducted a systematic literature review for relevant studies. Sixty-five patients were included, and two patients (3.1%) were diagnosed with GCA. Patients with GCA were older in age (median 85 versus 69 years, p = 0.02). ESR and CRP were significantly increased and hemoglobin was significantly lower in GCA patients compared to non-GCA patients (median, 75 versus 11 mm in 1 h, p = 0.001; 3.84 versus 0.25 mg/dl, p = 0.01, 10.4 versus 14.6 mg/dl, p = 0.003, respectively). Multiple stenoses/occlusions in the vertebrobasilar territory affected our two GCA patients (100%), but only five (7.9%) non-GCA patients (p = 0.01). Our literature review identified 13 articles with 136 stroke patients with concomitant GCA. Those were old in age. Headache, increased inflammatory markers, and anemia were frequently reported. Multiple stenoses/occlusions in the vertebrobasilar territory affected around 70% of stroke patients with GCA. Increased inflammatory markers, older age, anemia, and multiple stenoses/occlusions in the vertebrobasilar territory may be regarded as red flags for GCA among patients with vertebrobasilar stroke.