Filtern
Volltext vorhanden
- ja (43)
Gehört zur Bibliographie
- ja (43)
Erscheinungsjahr
Dokumenttyp
Sprache
- Englisch (43) (entfernen)
Schlagworte
- glaucoma (6)
- glaucoma surgery (6)
- trabeculectomy (5)
- age-related macular degeneration (3)
- bevacizumab (3)
- trabectome (3)
- trabecular meshwork (3)
- Glaukom (2)
- ab interno trabeculectomy (2)
- association (2)
- exact matching (2)
- eyes (2)
- non-penetrating glaucoma surgery (2)
- postoperative care (2)
- retinal pigment epithelium (2)
- 5-fluorouracil (1)
- AMD (1)
- Ab Interno Trabekulektomie (1)
- Ab interno trabeculectomy (1)
- Ahmed (1)
- Alternaria (1)
- Anterior chamber perfusion model (1)
- Apoptosis (1)
- Aspergillus (1)
- Augenkrankheit (1)
- Baerveldt (1)
- Bevacizumab (1)
- Bone morphogenetic protein-2 (1)
- CYR61 (1)
- Canaloplasty (1)
- Cancer (1)
- Devic syndrome (1)
- Distal outflow trac (1)
- Draize eye test (1)
- Fluorescein angiography (1)
- Fusarium (1)
- Glaucoma (1)
- Goniotomie (1)
- Incontinentia pigmenti (1)
- MAP kinase pathway (1)
- Mechanisms (1)
- Medizin (1)
- Myelin oligodendrocyte glycoprotein antibodies (MOG-IgG) (1)
- Myofibroblast differentiation (1)
- Müller cells (1)
- NMO-IgG (1)
- Necrotizing enterocolitis (1)
- Netarsudil (1)
- Non-penetrating glaucoma surgery (1)
- OCT angiography (1)
- OECD guideline (1)
- Phacocanaloplasty (1)
- Phacotrabeculectomy (1)
- Porcine eye (1)
- Proliferation (1)
- Purpureocillium (1)
- Receptor (1)
- Retinal arterial macroaneurysms (1)
- Retinopathy (1)
- Rho-kinase inhibitor (1)
- Scedosporium (1)
- Scheimpflug (1)
- Smooth-muscle-cells (1)
- Streptomyces (1)
- TGF-beta (1)
- TGFβ signaling (1)
- Trabeculectomy (1)
- Trabekulopunktion (1)
- Tropheryma whipplei (1)
- United States (1)
- VEGF (1)
- Wegener’s granulomatosis (1)
- Whipple's disease (1)
- actin (1)
- actinomycetes (1)
- actins (1)
- adhesion (1)
- aging (1)
- alternatives (1)
- antifungal susceptibility (1)
- aquaporin-4 antibodies (AQP4-IgG) (1)
- aqueous humor outflow (1)
- beaver-dam eye (1)
- behavior (1)
- biodegradable implant (1)
- biofilms (1)
- bioreactor (1)
- bleb failure (1)
- bleb scarring (1)
- canal surgery (1)
- canaloplasty (1)
- case report (1)
- cased-control studies (1)
- cataract surgery (1)
- cell cultures (1)
- cell staining (1)
- central corneal thickness (1)
- chorioretinal lesions (1)
- ciliolenticular block glaucoma (1)
- circumferential viscodilation (1)
- collagen-glycosaminoglycane matrix (CGM) (1)
- complement factor-H (1)
- cones (1)
- conjunctival defect (1)
- conjunctival hole (1)
- conjunctival repair (1)
- contact lens (1)
- corneal endothelium (1)
- corneal epithelium (1)
- corneal equivalent (1)
- corneal storage (1)
- cyclophosphamide (1)
- cytoskeleton (1)
- drainage tube (1)
- elastic magnetic-materials (1)
- ellipsoid (1)
- endophthalmitis (1)
- episcleral drainage device (1)
- epithelial-mesenchymal transition (1)
- esohypotropia (1)
- expression (1)
- extracellular matrix (1)
- eye diseases (1)
- eye infection (1)
- eye irritation testing (1)
- ferroptosis (1)
- flexible microcatheter (1)
- fluorophores (1)
- fungal infection (1)
- genetic loci (1)
- genetics of disease (1)
- genome-wide scan (1)
- genotyping (1)
- giant cell arteritis (1)
- glaucoma drainage device (1)
- glaucoma progression (1)
- goldmann applanation tonometer (1)
- grading system (1)
- granulomatosis with polyangiitis (1)
- haze (1)
- heavy eye (1)
- hemorrhages (1)
- high myopia (1)
- histology (1)
- human genetics (1)
- human retinal pigment epithelium (1)
- hydrogels (1)
- hyperspectral autofluorescence imaging (1)
- iStent (1)
- identification (1)
- intraocular pressure (1)
- intravenous ceftriaxone (1)
- intravitreal vancomycin and amikacin (1)
- keratitis (1)
- laser suture lysis (1)
- laterality (1)
- macular degeneration (1)
- maculopathy (1)
- magnetic resonance imaging (1)
- magnetorheological elastomers (1)
- malignant glaucoma (1)
- marine sponges (1)
- matrix metalloproteases (1)
- mechanics (1)
- mechanotransduction (1)
- medicine (1)
- membrane (1)
- microbiome (1)
- microfilament (1)
- microtubules (1)
- mitomycin C (1)
- months follow-up (1)
- multifocal choroiditis (1)
- muscle dislocation (1)
- nasal mucosal barrier function (1)
- natamycin (1)
- neuro-/photoreceptor degeneration (1)
- neuromyelitis optica (1)
- neuromyelitis optica spectrum disorders (NMOSD) (1)
- nycthemeral intraocular pressure (1)
- ocular anterior segment perfusion culture (1)
- ocular infection (1)
- ologen implant (1)
- onset (1)
- open-angle glaucoma (1)
- ophthalmic artery (1)
- optic nerve (1)
- optic neuritis (1)
- optical coherence tomography (1)
- oral cefpodoxime (1)
- oral doxycycline (1)
- orbit (1)
- outer retinal tubulation (1)
- pars plana vitrectomy (1)
- patient (1)
- phacocanaloplasty (1)
- phacotrabeculectomy (1)
- photodynamic therapy (1)
- photoreceptors (1)
- pigment epithelium derived factor (1)
- population (1)
- prevalence (1)
- proteolysis (1)
- ranibizumab (1)
- releasable suture (1)
- retina (1)
- retinal neuro-axonal damage (1)
- retinal vasculitis (1)
- retinitis pigmentosa (1)
- riboflavin (1)
- right-left comparison (1)
- secondary (1)
- secondary CNV (1)
- selective retina therapy (1)
- series (1)
- smooth muscle actin (1)
- spectral characterization (1)
- spectral-domain optical coherence tomography (1)
- staphilococci (1)
- stiffness (1)
- strabismus fixus (1)
- stress fiber (1)
- surgical outcomes (1)
- susceptibility (1)
- systemic immunosuppression (1)
- tension (1)
- tight junction (1)
- tissue culture (1)
- tissue engineering (1)
- to-disc ratio (1)
- topic ofloxacin (1)
- trabecular bypass stent (1)
- trabeculopuncture (1)
- trabex+ (1)
- ultraviolet-a (1)
- variant genotypes (1)
- variants (1)
- vascular endothelial growth factor (1)
- vision (1)
- visual acuity (1)
- visual evoked potentials (1)
- vitamin C (1)
- vitrectomy (1)
Institut
- Augenklinik und Poliklinik (43) (entfernen)
Sonstige beteiligte Institutionen
EU-Projektnummer / Contract (GA) number
- 311932 (1)
Purpose: Scarring after glaucoma filtering surgery remains the most frequent cause for bleb failure. The aim of this study was to assess if the postoperative injection of bevacizumab reduces the number of postoperative subconjunctival 5-fluorouracil (5-FU) injections. Further, the effect of bevacizumab as an adjunct to 5-FU on the intraocular pressure (IOP) outcome, bleb morphology, postoperative medications, and complications was evaluated.
Methods: Glaucoma patients (N = 61) who underwent trabeculectomy with mitomycin C were analyzed retrospectively (follow-up period of 25 ± 19 months). Surgery was performed exclusively by one experienced glaucoma specialist using a standardized technique. Patients in group 1 received subconjunctival applications of 5-FU postoperatively. Patients in group 2 received 5-FU and subconjunctival injection of bevacizumab.
Results: Group 1 had 6.4 ± 3.3 (0–15) (mean ± standard deviation and range, respectively) 5-FU injections. Group 2 had 4.0 ± 2.8 (0–12) (mean ± standard deviation and range, respectively) 5-FU injections. The added injection of bevacizumab significantly reduced the mean number of 5-FU injections by 2.4 ± 3.08 (P ≤ 0.005). There was no significantly lower IOP in group 2 when compared to group 1. A significant reduction in vascularization and in cork screw vessels could be found in both groups (P < 0.0001, 7 days to last 5-FU), yet there was no difference between the two groups at the last follow-up. Postoperative complications were significantly higher for both groups when more 5-FU injections were applied. (P = 0.008). No significant difference in best corrected visual acuity (P = 0.852) and visual field testing (P = 0.610) between preoperative to last follow-up could be found between the two groups.
Conclusion: The postoperative injection of bevacizumab reduced the number of subconjunctival 5-FU injections significantly by 2.4 injections. A significant difference in postoperative IOP reduction, bleb morphology, and postoperative medication was not detected.
Background
Cataract and glaucoma are both common comorbidities among older patients. Combining glaucoma surgery with minimal invasive phacoemulsification (phaco) is a considerable option to treat both conditions at the same time, although the combination with filtration surgery can produce a strong inflammatory response. Combined non-penetrating procedures like canaloplasty have shown to reduce intraocular pressure (IOP) comparable to trabeculectomy without the risk of serious bleb-related complications. The purpose of this retrospective study was to compare the outcomes of phacotrabeculectomy and phacocanaloplasty.
Methods
Thirty-nine eyes with concomitant cataract and glaucoma who underwent phacotrabeculectomy (n = 20; 51.3%) or phacocanaloplasty (n = 19; 48.7%) were included into this trial on reduction of IOP, use of medication, success rate, incidence of complications and postsurgical interventions. Complete success was defined as IOP reduction by 30% or more and to 21 mmHg or less (definition 1a) or IOP to less than 18 mmHg (definition 2a) without glaucoma medication.
Results
Over a 12-month follow-up, baseline IOP significantly decreased from 30.0 ± 5.3 mmHg with a mean of 2.5 ± 1.2 glaucoma medications to 11.7 ± 3.5 mmHg with a mean of 0.2 ± 0.4 medications in eyes with phacotrabeculectomy (P < .0001). Eyes with phacocanaloplasty had a preoperative IOP of 28.3 ± 4.1 mmHg and were on 2.8 ± 1.1 IOP-lowering drugs. At 12 months, IOP significantly decreased to 12.6 ± 2.1 mmHg and less glaucoma medications were necessary (mean 1.0 ± 1.5 topical medications; P < .05). 15 patients (78.9%) with phacotrabeculectomy and 9 patients (60.0%) in the phacocanaloplasty group showed complete success according to definition 1 and 2 after 1 year (P = .276). Postsurgical complications were seen in 7 patients (36.8%) of the phacocanaloplasty group which included intraoperative macroperforation of the trabeculo-Descemet membrane (5.3%), hyphema (21.1%) and bleb formation (10.5%). Although more complications were observed in the phacotrabeculectomy group, no statistically significant difference was found.
Conclusions
Phacocanaloplasty offers a new alternative to phacotrabeculectomy for treatment of concomitant glaucoma and cataract, although phacotrabeculectomy yielded in better results in terms of IOP maintained without glaucoma medications.
Pars plana vitrectomy for malignant glaucoma in non-glaucomatous and in filtered glaucomatous eyes
(2012)
Purpose: To assess the outcomes of pars plana vitrectomy for the treatment of malignant glaucoma in patients with and without previous filtration surgery. Patients and methods: Data of 15 patients developing malignant glaucoma after trabeculectomy (60%) or following ophthalmic interventions other than filtration surgery (40%) were recorded retrospectively. Pars plana vitrectomy was performed in case of failed medical or laser treatment recreating the normal pathway of aqueous humor. The main outcome measures were the postoperative intraocular pressure (IOP), the frequency of complications, and success rate based on the following criteria: IOP reduction by $20% and to #21 mmHg (definition one) or an IOP , 18 mmHg (definition two) with (qualified success) and without (complete success) glaucoma medication. Results: Vitrectomy reduced IOP from baseline in eyes with and without previous trabeculectomy during a median follow-up of 16.4 months (range 7 days to 58 months); although the majority of patients required glaucoma medication to reach desired IOP. The complete success rates were 11% (both definitions) for patients with filtering blebs and none of the patients without previous trabeculectomy had complete success at the 12-month visit. Complications were few and included transient shallowing of the anterior chamber, choroidal detachment, corneal decompensation, filtering bleb failure, and need for further IOP-lowering procedures. Conclusion: Pars plana vitrectomy is equally effective for malignant glaucoma caused by trabeculectomy or interventions other than filtration surgery, although IOP-lowering medication is necessary in nearly all cases to maintain target IOP.