Refine
Year of publication
- 2019 (471) (remove)
Document Type
- Journal article (471) (remove)
Language
- English (471) (remove)
Keywords
- apoptosis (8)
- inflammation (7)
- boron (6)
- cancer (5)
- ischemic stroke (5)
- DNA methylation (4)
- cancer therapy (4)
- children (4)
- deep brain stimulation (4)
- infection (4)
- measles virus (4)
- microbiome (4)
- multiple myeloma (4)
- sphingolipids (4)
- tissue engineering (4)
- GABA (3)
- Meningitis (3)
- Monte-Carlo (3)
- Neisseria meningitidis (3)
- Physics (3)
- Survival (3)
- Ureaplasma parvum (3)
- Ureaplasma urealyticum (3)
- aging (3)
- blood–brain barrier (3)
- boranes (3)
- climate change (3)
- cytokines (3)
- cytotoxicity (3)
- death receptors (3)
- depression (3)
- epigenetics (3)
- gephyrin (3)
- length of stenosis (3)
- leukemic cells (3)
- lysosome (3)
- machine learning (3)
- metagenomics (3)
- psychiatric disorders (3)
- remote sensing (3)
- risk factors (3)
- stem cells (3)
- stroke (3)
- virtual reality (3)
- 3D tissue model (2)
- Bees (2)
- Biomedical engineering (2)
- C-reactive protein (2)
- CXCR4 (2)
- Cancer (2)
- Candida albicans (2)
- Colonization (2)
- Constraints (2)
- Cross-Section (2)
- Cryo-EM (2)
- Decay (2)
- Exercise capacity (2)
- Expression (2)
- FKBP5 (2)
- GABAA receptors (2)
- HBMEC (2)
- HBV (2)
- HIV (2)
- Hadron colliders (2)
- HeLa cells (2)
- Imaging techniques (2)
- Impact (2)
- MSC (2)
- Metabolomics (2)
- Methylation (2)
- NHC (2)
- Neurons (2)
- PIP2 (2)
- Pair Production (2)
- Parton Distributions (2)
- Parton distributions (2)
- Radiative-corrections (2)
- Reduction (2)
- S-ADAPT (2)
- Sentinel-1 (2)
- Solution-state NMR (2)
- Stem cells (2)
- TNF receptor superfamily (2)
- TNF superfamily (2)
- TNFR1 (2)
- TRAIL (2)
- Tanzania (2)
- Top-Quark (2)
- VEGF (2)
- actin (2)
- adolescents (2)
- agriculture (2)
- allometric scaling (2)
- antibody (2)
- antibody fusion proteins (2)
- artemisinin (2)
- autophagy (2)
- bacteria (2)
- blood-brain barrier (2)
- body composition (2)
- body size (2)
- cAArC (2)
- calcium phosphate cement (2)
- cancer genomics (2)
- cancer immunotherapy (2)
- cancer metabolism (2)
- cardiomyopathy (2)
- carotid atherosclerosis (2)
- carotid stenosis (2)
- carotid ultrasound (2)
- caspase-8 (2)
- cell death (2)
- cell imaging (2)
- chemistry (2)
- colorectal cancer (2)
- complexes (2)
- copper (2)
- cystic fibrosis patients (2)
- degree of stenosis (2)
- dendritic cells (2)
- density functional calculations (2)
- diagnostic markers (2)
- diazepam (2)
- ecology (2)
- fluorescence (2)
- genetics (2)
- genome annotation (2)
- genome assembly (2)
- geomorphology (2)
- glioblastoma multiforme (2)
- glucocorticoid receptor (2)
- healthy volunteers (2)
- human behaviour (2)
- imaging (2)
- immunotherapy (2)
- inhibitory neurotransmission (2)
- interleukin-8 (2)
- irradiation (2)
- knockout (2)
- lymphocytes (2)
- magnetic properties and materials (2)
- magnetic resonance imaging (2)
- melt electrospinning writing (2)
- meningitis (2)
- mental health (2)
- mesencephalic locomotor region (2)
- metabolic adaptation (2)
- microtubules (2)
- migration (2)
- mitochondria (2)
- molecular biology (2)
- mouse (2)
- multiple sclerosis (2)
- neuroinflammation (2)
- neurology (2)
- neuroprotection (2)
- oncology (2)
- oncolytic virus (2)
- outcome (2)
- p53 (2)
- pathogens (2)
- performance (2)
- personalized medicine (2)
- photothrombotic stroke (2)
- polycyclic aromatic hydrocarbons (2)
- polymers (2)
- population pharmacokinetics (2)
- presence (2)
- prognosis (2)
- radicals (2)
- recurrence (2)
- relapse (2)
- ring-expansion reaction (2)
- semiconductor lasers (2)
- smartphone app (2)
- software (2)
- structure (2)
- surgery (2)
- survival (2)
- tight junction (2)
- trade-offs (2)
- two-photon excited fluorescence (2)
- ubiquitin (2)
- (classical and atypical) Werner syndrome (1)
- + (1)
- ++ (1)
- 18F-FDS (1)
- 2 Jets (1)
- 2-deoxy-2-18F-fluoro-D-sorbitol (1)
- 25-hydroxycholesterol 7 alpha-hydroxylase (1)
- 2Dimensionale Spektroskopie (1)
- 3-coordinate organoboron compounds (1)
- 3D (1)
- 3D printing (1)
- 3D remote sensing (1)
- 3 T (1)
- 4D flow (1)
- ABP1 (1)
- AHRR (1)
- ALAN (1)
- AMP-activated kinases (1)
- APRI (1)
- ARCI (1)
- ARCI EM type III (1)
- ATP generation (1)
- AUX1 (1)
- Accurate (1)
- Acids (1)
- Activation (1)
- Active disease (1)
- Acute myeloid leukemia (AML) (1)
- AdS-CFT Correspondence (1)
- Adherens junction (1)
- Adolescent (1)
- Adult (1)
- Akt/PKB (1)
- Alcohol dependence (1)
- Algorithm (1)
- Alien limb syndrome (1)
- Allogeneic transplantation (1)
- Alpine habitats (1)
- Alzheimer's disease (1)
- Anarchic limb syndrome (1)
- Andalusian varieties (1)
- Annotation (1)
- Anomalous magnetic-moment (1)
- Antarctica (1)
- Anthropocene (1)
- Antioxidants (1)
- Anxiety (1)
- Aortic arch (1)
- Apidae (1)
- Apis mellifera (1)
- Aplastic anemia (1)
- Apoptosis (1)
- Applied physics (1)
- Archaeology (1)
- Arylborylene Complexes (1)
- Ascaris lumbricoides (1)
- Aspergillus (1)
- Aspergillus fumigalus (1)
- Associative learning (1)
- Astrophysical neutrino sources (1)
- Atacama (1)
- Atmospheric muons (1)
- Atomic and molecular interactions with photons (1)
- Atrial fibrillation (1)
- Autologous hematopoietic stem cell transplantation (1)
- B cell malignancies (1)
- B cells (1)
- B,N-heterocylcles (1)
- B-B bond activation (1)
- B-MYB (1)
- B7-H1 (1)
- BAL (1)
- BCG (1)
- BMI (1)
- BRAF mutation (1)
- BRCA1 (1)
- Barrier (1)
- Behavioural ecology (1)
- Benzimidazole (1)
- Berberine (1)
- Bevacizumab (1)
- Bhabha Scattering (1)
- Binge drinking (1)
- Biomarke (1)
- Biophysics (1)
- Bipolar disorder (1)
- Bistability (1)
- Black Holes in String Theory (1)
- Black-hole (1)
- Blood (1)
- Body schema (1)
- Boson (1)
- Bosons (1)
- Brain cancer (1)
- Brain diseases (1)
- Brain endothelial cells (1)
- Branching fractions (1)
- Bronchopulmonary dysplasia (1)
- By-Light Scattering (1)
- B−H activation (1)
- C-60 fullerene (1)
- C-C coupling (1)
- C3a (1)
- C3aR (1)
- C5a (1)
- C5aR1 (1)
- C5aR2 (1)
- C60 fullerene (1)
- CAR T cells (1)
- CCI (1)
- CD274 (1)
- CD4+ T cells (1)
- CD8+ T cells (1)
- CD95 (1)
- CERN (1)
- CIDP (1)
- CMV (1)
- CO sensing (1)
- CO‐releasing molecules (CORMs) (1)
- CRH1 (1)
- CRISPR-Cas systems (1)
- CRM (1)
- CRMO (1)
- CVID (1)
- CXCL5 (1)
- CXCL8 (1)
- CXCR2 (1)
- CYP1B1 (1)
- C\(_{60}\) fullerene (1)
- Callyspongia siphonella (1)
- Cancer Cell (1)
- Cancer genetics (1)
- Capicua transcriptional repressor (1)
- Cardiac ventricles (1)
- Cardiovascular diseases (1)
- Cardiovascular risk factors (1)
- Cardiovascular risk prediction (1)
- Carotid intima-media thickness (CIMT) (1)
- Carotid segment (1)
- Carotid ultrasound (1)
- Caspase (1)
- Cell stainin (1)
- Central nervous system (1)
- Chambers (1)
- Characterization and analytical techniques (1)
- Chemical composition (1)
- Cherenkov underwater neutrino telescope (1)
- Children (1)
- Chile (1)
- Chili RNA Aptamer (1)
- Chlamydia trachomatis (1)
- Choice Behavior/physiology (1)
- Circinella (1)
- Circular dichroism (1)
- Clinically silent stroke (1)
- Cognitive behavior (1)
- Cognitive neuroscience (1)
- Community-acquired methicillin-resistant Staphylococcus aureus (1)
- Computational and Systems Biology (1)
- Computed axial tomography (1)
- Computer modelling (1)
- Conditioning regimen (1)
- Confocal microscopy (1)
- Conifers (1)
- Conservation (1)
- Consistent partial least squares (1)
- Corticobasal syndrome (1)
- Corticosteroids (1)
- Cosmic-rays (1)
- Couplings (1)
- CpG (1)
- Cranial sutures (1)
- Cross-section (1)
- Cushing’s disease (1)
- Cutaneous lymphoma (1)
- Cystic fibrosis (1)
- Cytochrome P 450 pathway (1)
- Cytosol (1)
- DC gate (1)
- DEM (1)
- DLS and AFM measurements (1)
- DNA damage (1)
- DNA electronic transport (1)
- DNA methyltransferases (1)
- DNA repair (1)
- DNA sequencing (1)
- DNA weight (1)
- DNA-repair (1)
- DNA-repair genes (1)
- DSB focus substructure (1)
- DSM (1)
- Dark-Matter (1)
- Dark-matter (1)
- Data acquisition (1)
- Deep Inelastic-scattering (1)
- Delbruck Scattering (1)
- Densovirus (1)
- Design (1)
- Developmental biology (1)
- Diagnosis prediction (1)
- Diagnostic medicine (1)
- Diffusion tensor imaging (1)
- Dihydroboranes (1)
- Disease severity (1)
- Dopamine (1)
- Double-Beta Decay (1)
- Doxorubicin (1)
- Drosophila (1)
- Drug discovery (1)
- Drug resistance (1)
- Dynamics (1)
- E(+)E(-) collicions (1)
- E2 conjugating enzyme (1)
- E3 ligating enzyme (1)
- EBF1 (1)
- EEA (1)
- EQ5D-5L (1)
- ER-Stress (1)
- ERK (1)
- ERK signaling (1)
- ERK1/2 (1)
- ESAT‐6‐like secretion system (1)
- ESS (1)
- EUROASPIRE (1)
- EWAS (1)
- Earth observation (1)
- Echinococcosis (1)
- Echinococcus (1)
- Ecology (1)
- Efflux transport (1)
- Eigenvectors (1)
- Elderly (1)
- Electrical impedance tomography (1)
- Electromagnetic signals (1)
- Electron (1)
- Electroweak Measurements (1)
- Electroweak Phase-Transition (1)
- Electroweak interaction (1)
- Elissen-Palm flux (1)
- Embryonic induction (1)
- Embryos (1)
- Emergence (1)
- Endoplasmic-Reticulum Stress (1)
- Energy (1)
- Enhancer elements (1)
- Entanglement (1)
- Environmental impact (1)
- Epidemiology (1)
- Epigenetic (1)
- Epigenetic regulation (1)
- Epstein-Barr virus-induced gene 2 (1)
- Equipment (1)
- EsaA (1)
- Escherichia coli (1)
- European Society for Immunodeficiencies (ESID) (1)
- European Spanish (1)
- European group (1)
- Event builder (1)
- Events GW150914 (1)
- Evolutionary developmental biology (1)
- Evolutionary emergence (1)
- Exercise testing (1)
- Extensions of gauge sector (1)
- Extracellular matrix (1)
- Extracellular volume (1)
- Extramedullary disease (1)
- Extreme flows (1)
- Exziton (1)
- Eye Movements/physiology (1)
- Eye development (1)
- FIB-4 (1)
- Fak regulation (1)
- Familial Beckwith-Wiedemann syndrome (1)
- FasL (1)
- Fatigue (1)
- Fats (1)
- Fear conditioning (1)
- Female (1)
- Fgf-signalling (1)
- Flavor Violation (1)
- Flowering plants (1)
- Flowers (1)
- Fludarabine (1)
- Fludarabine-treosulfan (FT) (1)
- Fluorescence spectroscopy (1)
- Forces (1)
- Forests (1)
- Fractional cover analysis (1)
- Full body ownership illusion (1)
- Fusarium (1)
- G-2 (1)
- GABAA (1)
- GAD1 (1)
- GRP78 (1)
- GSV (1)
- GVHD (1)
- Galactic sources (1)
- Gaseous detectors (1)
- Gauge bosons (1)
- Gauge-gravity correspondence (1)
- Gaussian approximation (1)
- Gene expression analysis (1)
- Gene silencing (1)
- General anaesthesia (1)
- Generation (1)
- Genome (1)
- Genomics (1)
- Genotype (1)
- Geriatric care (1)
- Geriatrics (1)
- German PID-NET registry (1)
- Germany (1)
- Germline (1)
- Getz Ice Shelf (1)
- Glioblastoma (1)
- Glutathione (1)
- Google Earth Engine (1)
- Gravitons (1)
- Greenland ice sheet (1)
- Group B Streptococcus (1)
- Gruppo-italiano (1)
- H-infinity (1)
- HCV (1)
- HDAC (1)
- HEMA (1)
- HNSCC (1)
- HPA axis (1)
- HRQOL (1)
- Hadron-Hadron scattering (experiments) (1)
- Hadron-hadron interactions (1)
- Haemophilus influenzae (1)
- Health (1)
- Heart (1)
- Heart failure (1)
- Hematopoietic Stem (1)
- Hematopoietic cell transplant (1)
- Heme-regulated inhibitor (1)
- Hemipelvectomy (1)
- Hfq (1)
- Higgy-Boson (1)
- High grade glioma (1)
- High-Energies (1)
- Hindbrain (1)
- Histone deacetylase (1)
- Hodgkin lymphoma (1)
- Honey bees (1)
- Hordeum vulgare (1)
- Host-parasite interaction (1)
- Human Muse Cells (1)
- Human behaviour (1)
- Humans (1)
- Hunsrueck (1)
- Hyperosmotic Stress (1)
- Hypothalamus (1)
- Hypothetical gauge bosons (1)
- IFN (1)
- IL-10 (1)
- IP3 (1)
- Icecube (1)
- IgG substitution therapy (1)
- Immune system (1)
- Immune-related adverse event (1)
- Immunology (1)
- Immunoprecipitation (1)
- Impella (1)
- Implicit and explicit reward learning (1)
- InSAR (1)
- InSAR height (1)
- Incontinentia pigmenti (1)
- Induced apoptosis (1)
- Inducible Clindamycin Resistance (1)
- Infectious disease (1)
- Inflammatio (1)
- Inflammatory diseases (1)
- Insect flight (1)
- Interleukin-10 (1)
- Interleukin-6 (1)
- Ipilimumab (1)
- Ischemic stroke (1)
- JAK2 (1)
- KDELR2 (1)
- KIF (1)
- KIF11 (1)
- KM3NeT (1)
- Kilombero (1)
- Knee (1)
- LATE DEATHS (1)
- LC-HRESIMS (1)
- LHC (1)
- LSD1 (1)
- LST (1)
- Land Change Modeler (1)
- Landsat time series (1)
- Lantana camara (1)
- Laparoscopy (1)
- Large Hadron Collider (1)
- Late mortality (1)
- Latin America (1)
- Learning and memory (1)
- Learning/physiology (1)
- Leptonic (1)
- Lichtheimia (1)
- Lifetime spectroscopy (1)
- Limb development (1)
- Limb salvage (1)
- Limestone (1)
- Llullaillaco Volcano (1)
- Low risk alcohol use (1)
- Lung disease, (1)
- Lymph nodes (1)
- Lysine-specific methylase (1)
- M14 carboxypeptidasses (1)
- MASS (1)
- MCP1 (1)
- MDSC (1)
- MGMT promoter methylation (1)
- MIBG (1)
- MLST (1)
- MODIS (1)
- MOLLI (1)
- MRI spectroscopy (1)
- Maculinea butterfly (1)
- Magnetic resonance imaging (1)
- Male (1)
- Manganese Carbonyl ligands (1)
- Masticatory mucosa (1)
- Mastoid process (1)
- Matter (1)
- Mc4r (1)
- Measurement error correlation (1)
- Meat (1)
- Mechanisms (1)
- Medical research (1)
- Melanoma (1)
- Memory B cells (1)
- Mesenchymal stem/stromal cells (1)
- Messenger-RNAs (1)
- Methicillin-resistant Staphylococcus aureus (1)
- Mfn2 KO mice (1)
- Microbiology and Infectious Disease (1)
- Midollo-Osseo (1)
- Migration (1)
- Minimal change disease (1)
- Minimally invasive surgery (1)
- Missing Energy (1)
- Mitochondria (1)
- Mobile genetic element (1)
- Model specification (1)
- Monte Carlo simulation (1)
- Motor behaviour (1)
- Mouse (1)
- Movement behavior (1)
- Mucor (1)
- Mucorales (1)
- Multiple (1)
- Multiple myeloma (1)
- Multiple-Scattering (1)
- Multiplex PCR (1)
- Muon spectrometers (1)
- Muscle function (1)
- Muscle power (1)
- Myb-MuvB (1)
- Myrmica ant non-equilibrium dynamics (1)
- N-heterocyclic olefins (1)
- NAFLD (1)
- NASH (1)
- NCH93 (1)
- NCI-H295R (1)
- NF-Kappa-B (1)
- NF-κB/NFAT reporter cells (1)
- NFATc1 (1)
- NFκB (1)
- NHCs (1)
- NH\(_{3}\) (1)
- NIPAL4 (1)
- NIR OLED (1)
- NLO Computations (1)
- Nanoparticles (1)
- Nasal Carriage (1)
- Necrotizing enterocolitis (1)
- Nectin‐2 (1)
- Neisseria gonorrhoeae (1)
- Neolithic period (1)
- Netherlands (1)
- Neural Differentiation (1)
- Neural circuits (1)
- Neuroinflammation (1)
- Neuroscience (1)
- Neutrino Detectors and Telescopes (experiments) (1)
- Neutrino Mass (1)
- Nfatc1 (1)
- Nivolumab (1)
- Nonlinear Dynamics (1)
- Non‐ischaemic cardiogenic shock (1)
- Nursing homes (1)
- OSCC (1)
- OSI (1)
- Object recognition (1)
- Oculomotor Muscles/physiology (1)
- Oncology (1)
- Optical spectroscopy (1)
- Oral anticoagulation (1)
- Oscillation (1)
- Outer membrane proteins (1)
- P(P) over-bar collisions (1)
- P-glycoprotein (1)
- P-gp (1)
- PA-flexed view (1)
- PALS (1)
- PCR (1)
- PD-1 (1)
- PD-L1 (1)
- PET/CT (1)
- PID prevalence (1)
- PP collisions (1)
- PTEN (1)
- Parkinson’s disease (1)
- Particle accelerators (1)
- Particle tracking detectors (Gaseous detectors) (1)
- Particle-acceleration (1)
- Parvovirus (1)
- Pathogenesis (1)
- Pathogens (1)
- Pavlovian-to-instrumental transfer (1)
- Pentixafor (1)
- Personalized medicine (1)
- Pflanzen (1)
- Phase- (1)
- Phenols (1)
- Phosphorylation (1)
- Photic (1)
- Physical activity (1)
- Plant signalling (1)
- Plants (1)
- Polygonum cuspidatum (1)
- Polymer-drug interaction (1)
- Polymers (1)
- Poplars (1)
- Positron annihilation spectroscopy (1)
- Positron-Emission Tomography (1)
- Positronen-Emissions-Tomografie (1)
- Postoperative complications (1)
- Premna (1)
- Preterm birth (1)
- Prevalence (1)
- ProQ (1)
- Prognostic markers (1)
- Prognostic scoring system (1)
- Protein (1)
- Protein folding (1)
- Protein kinase D3 (PKD3) (1)
- Proteus vulgaris (1)
- Proton-Proton Collisions (1)
- Psychiatric disorders (1)
- Psychology (1)
- Psychomotor Performance/physiology (1)
- Pulmonary function tests (1)
- Quality-control (1)
- Quantum electrodynamics (1)
- R package (1)
- RCT (1)
- RNA expression (1)
- RNA metabolism (1)
- RNA sequencing (1)
- RNA-seq (1)
- RNA-seq transcriptome (1)
- RNAi (1)
- RNAlater (1)
- ROR1 (1)
- RSV-A ON1 (1)
- RT-qPCR (1)
- Radiation (1)
- Radiation exposure (1)
- Radiographs (1)
- Radiotherapy (1)
- RapidEye (1)
- Regimes (1)
- Relativistic heavy-ion collisions (1)
- Reminder e-mails (1)
- Remnant RX J1713.7-3946 (1)
- Research Article (1)
- Respiratory tract infection (1)
- Retinopathy (1)
- Rhizomucor (1)
- Rhizopus (1)
- Robotics (1)
- Ruthenium (1)
- Ruxolitinib (1)
- S. aureus (1)
- SASHA (1)
- SB332235 (1)
- SPOT-6 (1)
- SR/mitochondria metabolic feedback (1)
- ST 772 (1)
- ST18 (1)
- SWAT (1)
- SWAT model (1)
- Saccades/physiology (1)
- Salmo trutta fario (1)
- Scarabaeidae (1)
- Scattering (1)
- Scenario analysis (1)
- Screening (1)
- Secondary stroke prevention (1)
- Sediment (1)
- Self-navigation (1)
- Self-renewal (1)
- Sentinel-2 (1)
- Serine proteases (1)
- Serotonin (1)
- Sex chromosome (1)
- Sex determination (1)
- Sexual development and function (1)
- ShMOLLI (1)
- Shell (1)
- Sibling donor (MSD) (1)
- Silver (1)
- Simulation (1)
- Single Molecule Localization Microscopy (SMLM) (1)
- Single-Photon (1)
- Skin (1)
- Skull (1)
- Small interfering RNAs (1)
- Smoking (1)
- Societe Francaise (1)
- Soft tissues (1)
- Solid tumors (1)
- Somites (1)
- Species delimitation (1)
- Specimen grinding (1)
- Spektroskopie (1)
- Staphylococcus aureus (1)
- Staphylococcus aureus USA300 (1)
- Stem cell (1)
- Stem-cell biotechnology (1)
- Stereochemistry (1)
- Stimulation (1)
- Stokes-shifted fluorescence emission (1)
- Strains (1)
- Strange Baryon Production (1)
- Stratigraphy (1)
- Streptococcus agalactiae (1)
- Stroke unit (1)
- Stromal cells (1)
- Structural equation modelling (1)
- Structure elucidation (1)
- Subject (1)
- Subtercola vilae (1)
- Supernova (1)
- Support vector machine (1)
- Supportive therapy (1)
- Surgical and invasive medical procedures (1)
- Surgical oncology (1)
- Survey (1)
- Swine (1)
- Syap1 knockout (1)
- Symmetry (1)
- Systemic sclerosis (1)
- T cell (1)
- T cell receptor (1)
- T cell suppression (1)
- T cells (1)
- T-cell lymphoma (1)
- T1 mapping (1)
- TDDFT (1)
- TDMT (1)
- TEV (1)
- TGFβ/BMP signaling (1)
- TLR2 (1)
- TLR4 (1)
- TNF (1)
- TNF-alpha (1)
- TNFR family costimulatory receptors (1)
- TNFR2 (1)
- TNFR2 agonists (1)
- TNFR2 antagonism (1)
- TNFα (1)
- TNNI3 (1)
- TP53 (1)
- TPCA1 (1)
- TRAF1 (1)
- TRAF2 (1)
- TRAILR1 (1)
- TRAILR2 (1)
- TanDEM-X (1)
- TeV energies (1)
- Temozolomide (1)
- Terramechanics (1)
- Thiotepa-busulfan-fludarabine (TBF) (1)
- Time resolved measurements (1)
- Toddler (1)
- Top quark (1)
- Torque (1)
- Tractography (1)
- Transcription (1)
- Transcription factor NRF1 (1)
- Transcriptomic (1)
- Translation (1)
- Translation Initiation (1)
- Translational research (1)
- Transposable element (1)
- Transverse-Momentum (1)
- Trees (1)
- Tregs (regulatory T cells) (1)
- Triticeae (1)
- Triticum aestivum (1)
- Trousseau's syndrome (1)
- Tubulin (1)
- U-Net (1)
- UV/Vis spectroscopy (1)
- UV–Vis (1)
- Ultrarelativistic Heavy-Ion (1)
- Unrelated donor (UD) (1)
- Ustilago maydis (1)
- V-ATPase (1)
- VLBW (1)
- VMAT (1)
- Valentine Leukocidin Genes (1)
- Valgus osteoarthritis (1)
- Value at Risk (1)
- Vcsels (1)
- View (1)
- Visuo-tactile congruency (1)
- W & Z bosons (1)
- WSS (1)
- Weak-Interactions (1)
- Wheel (1)
- Wire chambers (MWPC, Thin-gap chambers, drift chambers, drift tubes, proportional chambers etc) (1)
- X-ray radiography (1)
- YAP (1)
- Yoga (1)
- Young Adult (1)
- Zebrafish (1)
- Zinc (1)
- ZnO-NP (1)
- [68Ga]Pentixafor (1)
- \(^{177}\)Lu-OPS201 (1)
- abdominal surgery (1)
- absolute bioavailability (1)
- accidents (1)
- accumulation (1)
- accuracy (1)
- acetate (1)
- acid ceramidase (1)
- acid ceramidase inhibitor ceranib-2 (1)
- acoustic radiation force impulse imaging (1)
- acrophobia (1)
- action control (1)
- activated delayes flourescence (1)
- activation (1)
- active galactic nuclei (1)
- active ingredients (1)
- acute kidney injury (1)
- acute lymphoblastic leukemia (1)
- adaptive choice-based conjoint (1)
- additive manufacturing (1)
- adenoma (1)
- adenotonsillectromy (1)
- adiposity (1)
- adrenocortical carcinoma (1)
- adult attention deficit/hyperactivity disorder (adult ADHD) (1)
- advanced breast cancer (1)
- aerobic fitness (1)
- affect bursts (1)
- age at onset (1)
- age groups (1)
- age-related macular degeneration (1)
- agroecology (1)
- airway management (1)
- alternative splicing (1)
- altitudinal gradients (1)
- alveolar epithelium (1)
- amphiphilic block copolymer (1)
- amsacrine (1)
- amyloidoma (1)
- amyotrophic lateral sclerosis (1)
- amyotrophic lateral sclerosis (ALS) (1)
- analysis of variance (1)
- animal behaviour (1)
- animal physiology (1)
- anime (1)
- anomaly detection (1)
- anorexia nervosa (1)
- anti-contactin-1 (1)
- anti-depressant drug (1)
- antibacterial (1)
- antibacterial activity (1)
- antibiofilm (1)
- antibiotic resistance (1)
- anticancer (1)
- antifungal (1)
- antitrypanosomal (1)
- anti‐aging (1)
- anxiety generalization (1)
- anxiolytics (1)
- aortocaval fistula model (1)
- appraisal theory of emotion expression (1)
- arctic greening (1)
- arenes (1)
- artificial intelligence (1)
- artificial light at night (1)
- aspergillosis (1)
- asylum seekers (1)
- asylum status (1)
- atmospheric waves (1)
- atrial fibrillation (1)
- attention (1)
- auto-planning (1)
- autoantibody (1)
- autobiography (1)
- auxin (1)
- axillary dissection (1)
- bacterial pathogen (1)
- bacterial physiology (1)
- bacteriology (1)
- baghdadite (1)
- balancing trade-offs (1)
- bank mergers (1)
- bariatric surgery (1)
- behavior (1)
- behavioral plasticity (1)
- bench press (1)
- bending strength (1)
- benige tumor (1)
- beta-lactam antibiotics (1)
- biceps tendinitis (1)
- biceps tendon (1)
- big earth data (1)
- bilateral internal carotid artery stenosis (1)
- binary species (1)
- biofabricated vascular graft (1)
- bioinformatics (1)
- bioinformatics tool (1)
- bioink (1)
- biokinetics (1)
- biological rhythm (1)
- biological techniques (1)
- biologics (1)
- biomarker (1)
- biomarker signature (1)
- biomaterial ink (1)
- biomaterials – cells (1)
- biomechanics (1)
- biomolecular processes (1)
- biophysics (1)
- biotechnology (1)
- biotic interaction (1)
- bispecific antobodies (1)
- bisulfite pyrosequencing (1)
- black trout syndrome (1)
- bladder (1)
- blazars (1)
- blinatumoman (1)
- blinking (1)
- blocking phagocytosis (1)
- blood (1)
- blood-cerebrospinal fluid barrier (1)
- bone (1)
- bone adhesive (1)
- bone critical size defect (1)
- bone graft substitutes (1)
- bone marrow stromal cells (1)
- bone metastases (1)
- bone microenvironment (1)
- boolean modeling (1)
- boreholes (1)
- borohydrides (1)
- boronate (1)
- boronic acid (1)
- borylenes (1)
- bottom-up processing (1)
- brain (1)
- brain development (1)
- brain disorders (1)
- brain endothelial cell (1)
- brain endothelial cells (1)
- brain networks (1)
- brain plasticity (1)
- brain tumor (1)
- breast cancer (1)
- bridge-to-transplant (1)
- bronchoalveolar lavage fluid (1)
- bronchopulmonary dysplasia (1)
- brown trout (1)
- bullae (1)
- burn severity (1)
- burnt-wood (1)
- calcium (1)
- calcium phosphate (1)
- calnexin (1)
- calving front (1)
- cancer imaging (1)
- carabid beetles (1)
- carbon (1)
- carbon monoxide (1)
- cardiac metabolism (1)
- cardiac remodelling (1)
- cardiac surgery (1)
- cardiolipin (1)
- cardiopulmonary bypass (1)
- cardiovascular genetics (1)
- cardiovascular risk factors (1)
- care (1)
- cartilage repair (1)
- catchment (1)
- catheterization (1)
- catheters (1)
- caveolin-1 (Cav-1) (1)
- cefotiam (1)
- cell biology (1)
- cell death and immune response (1)
- cell death in the nervous system (1)
- cell differentiation (1)
- cell growth (1)
- cell migration (1)
- cell signalling (1)
- cell therapy (1)
- cell therapy and immunotherapy (1)
- cellular neuroscience (1)
- ceramide (1)
- cerebral microbleeds (1)
- cerebrospinal fluid (1)
- cervical dystonia (1)
- channelrhodopsins (1)
- chaperones (1)
- chemical engineering (1)
- chemokine (1)
- chemokine receptor (1)
- child behavior (1)
- chimeric antigen receptor (1)
- chirality (1)
- chirality-induced spin selectivity (1)
- chlamydia (1)
- chlorophyll fluorescence imaging (1)
- cholesterol (1)
- cholesterol 25 hydroxylase (1)
- cholesteryl ester (1)
- chondrocyte (1)
- chondrogenesis (1)
- chronic kidney disease (CKD) (1)
- chronic non-bacterial osteomyelitis (1)
- circRNA (1)
- circadian rhythm (1)
- circular transcriptome sequencing (1)
- cisplatin (1)
- claudin-5 (1)
- climate extremes (1)
- clinical characteristics (1)
- clinical imaging (1)
- clinical outcome (1)
- clinical trial (1)
- cluster analysis (1)
- co-culture (1)
- coagulation system (1)
- coastline (1)
- cognitive control (1)
- coherence (1)
- coherent risk measures (1)
- cold adaptation (1)
- collagen sponge (1)
- collimator (1)
- collodion baby (1)
- collybistin (1)
- colonization (1)
- common diseases (1)
- comparative genomics (1)
- comparison (1)
- competition (1)
- complement deposition (1)
- complement factor H (1)
- complex DNA damage (1)
- composite material (1)
- composition (1)
- computational science (1)
- computer-mediated communication (1)
- concealed information test (1)
- conditioning (1)
- congruency sequences (1)
- consensus (1)
- conservation (1)
- constructed trade-offs (1)
- context-based teaching (1)
- contextual fear conditioning (1)
- continuous theta burst stimulation (cTBS) (1)
- continuum limit (1)
- control levels (1)
- convolutional neural network (1)
- copeptin (1)
- coping (1)
- copy number variation (1)
- cortical excitability (1)
- cortical silent period (1)
- count time series (1)
- cristal engeneering (1)
- crop statistics (1)
- cross-coupling (1)
- cross-sectional study (1)
- cryosphere (1)
- cryostructured scaffolds (1)
- curcumin (1)
- curvature (1)
- cuticular permeability (1)
- cyclic compounds (1)
- cyclophosphamide (FLAMSA) (1)
- cytoskeleton (1)
- cytotoxic (1)
- daratumumab (1)
- data warehouse (1)
- dead-wood enrichment (1)
- decay (1)
- deception (1)
- deep learning (1)
- default-interventionist framework (1)
- definition (1)
- dehydrocoupling (1)
- dehydrogenaticve borylation (1)
- democracy (1)
- democracy profiles (1)
- dendritic cell (1)
- denosumab (1)
- depth dose curves (1)
- desk-based (1)
- desmin (1)
- desmin-related myopathy (1)
- desminopathy (1)
- desmoglein (1)
- desmoplastic small round cell tumor (1)
- desmosome (1)
- deubiquitinases (1)
- developmental forms (1)
- dexamethasone (1)
- diabetes (1)
- diacylglycerol (1)
- diacylglycerol (DAG) (1)
- dialysis adequacy (1)
- diazadiborinines (1)
- diboration (1)
- diborenes (1)
- diborynes (1)
- differentiation (1)
- differentiation potential (1)
- diffuse large B-cell lymphoma (1)
- diffusion weighted mri (1)
- digital health (1)
- dimeric peptide (1)
- direct muss spectrometric profiling (1)
- discrete systems (1)
- disease genetics (1)
- dissolution rates (1)
- distractor-response binding (1)
- distributed control (1)
- distributed learning (1)
- distributions (1)
- diversity gradients (1)
- document analysis (1)
- domain-specific language (1)
- donor (1)
- donor-acceptor systems (1)
- dopamine (1)
- dorsal root ganglion (1)
- dosimetry (1)
- double arc (1)
- doxorubicin (1)
- driving simulation (1)
- drought (1)
- drug delivery (1)
- drug release (1)
- drug resistance evolution (1)
- dual setting system (1)
- duchenne muscular dystrophy (1)
- duplication-deficiency (1)
- dyes (1)
- dynamic facial emotion expression (1)
- dystonia (1)
- e(+)e(-) Collisions (1)
- early brain injury (1)
- early-life stress (1)
- earlywood (1)
- eccentric hypertrophy (1)
- ecosystem service (1)
- ecosystem services (1)
- effective point of measurement (1)
- efficient intervention points (1)
- electrical resistivity tomography (1)
- electrochemistry (1)
- electron-precise diborates (1)
- electronic properties and materials (1)
- elementary body (1)
- eletrhydrodynamic (1)
- emergency care (1)
- emission (1)
- emotion enactment (1)
- emotion processing (1)
- emotion recognition (1)
- emotional behavior (1)
- emotions (1)
- emulsions oil-in-water (1)
- en bloc transfer (1)
- enantiomers (1)
- end-stage renal disease (1)
- endocytosis (1)
- endothelin-1 (1)
- endothelium (1)
- endurance (1)
- enercy-richness hypothesis (1)
- energy homeostasis (1)
- enhancer (1)
- environmental justice (1)
- environmental sciences (1)
- enzyme mechanism (1)
- enzymes (1)
- epidural block (1)
- epithelial-mesenchymal transition (1)
- epithelial-to-mesenchymal transition (1)
- error estimation (1)
- estimation error (1)
- ethics (1)
- eugenol (1)
- evapotranspiration (1)
- evolutionary ecology (1)
- evolutionary genetics (1)
- exciton (1)
- exciton-exciton (1)
- exercise intervention (1)
- expansion microscopy (1)
- expected value of control (1)
- extinction (1)
- extinction dynamics (1)
- extracellular domain (1)
- extramedullary hematopoiesis (1)
- extreme phenotypes (1)
- eye movement (1)
- eye movements (1)
- face (1)
- face-voice integration (1)
- faces (1)
- fan culture (1)
- fatigue (1)
- fault detection (1)
- fear (1)
- fear conditioning (1)
- fear learning (1)
- febrile seizures (1)
- feminist rap (1)
- femoral head (1)
- fertility (1)
- fibre length (1)
- fibromyalgia (1)
- fibrotest (1)
- fission (1)
- flash freezing (1)
- flora (1)
- flourescence quantum yield (1)
- flu-like symptoms (1)
- fluerescence (1)
- fluidics (1)
- fluorenscence (1)
- fluorescent probes (1)
- fluorine (1)
- fluoroarene (1)
- fluorogen-activating RNA aptamer (FLAP) (1)
- fluoroquinolone (1)
- food colorings (1)
- food resources (1)
- foraging patterns (1)
- forensic sample (1)
- forest ecology (1)
- forest fire (1)
- forest management (1)
- forest resources inventory (1)
- formation control (1)
- fractional variability (1)
- fracture (1)
- fragmentation functions (1)
- free choice (1)
- free radical polymerization (1)
- friut fly behaviour (1)
- full arc (1)
- fully convolutional neural networks (1)
- function (1)
- functional MRI (1)
- functional analysis (1)
- functional training (1)
- fungal ecology (1)
- fungal evolution (1)
- fungal molecular diagnostics (1)
- fungal rhodopsins (1)
- games (1)
- gangliosides and lipid rafts (1)
- gastric-bypass surgery (1)
- gastrointestinal cancer (1)
- gastrointestinal tract (1)
- gaze control (1)
- gem-bisboronates (1)
- gene alleles (1)
- gene expression analysis (1)
- gene family evolution (1)
- gene regulation (1)
- gene regulation in immune cells (1)
- genetic counselling (1)
- genetic engineering (1)
- genetic recombination (1)
- genetics of the nervous system (1)
- genome (1)
- genome analysis (1)
- genome-wide association studies (1)
- genomic imprinting (1)
- genomics (1)
- genotoxicity (1)
- glacier front (1)
- glacier terminus (1)
- glioblastoma multiforme (GBM) (1)
- glioma (1)
- global (1)
- global change (1)
- glucose transporter (1)
- glycine transporter 2 (1)
- glycoprotein Ibα (1)
- glycoprotein VI (1)
- glyvine uptake (1)
- graft vs. host disease (1)
- graft-versus host (1)
- graft-versus-host-disease (1)
- granules (1)
- gravitational waves (1)
- green fluorescence protein (GFP) (1)
- ground penetrating radar (1)
- ground-dwelling predators (1)
- growth (1)
- growth patterns (1)
- growth ring width (1)
- guided bone regeneration (1)
- guideline adherent treatment (1)
- guidelines (1)
- gut–liver axis (1)
- hA<sub>3</sub>AR (1)
- habit (1)
- habit strength (1)
- haematopoietic stem cell (1)
- halogens (1)
- head and neck squamous cell carcinoma (1)
- heart-to-mediastinum ratio (1)
- heat wave (1)
- helical molecules (1)
- helicenes (1)
- hematopoietic stem cell transplantation (1)
- heme oxygenase-1 (1)
- hemicraniectomy (1)
- hemodiafiltration (1)
- hemodialysis (1)
- hemophagocytosis (1)
- hemorrhagic (1)
- hemostasis (1)
- henoch-schönlein purpura (1)
- hepatitis B virus (1)
- hereditary breast and ovarian cancer (1)
- heterotypic scaffold design (1)
- high LET irradiation (1)
- high efficiency (1)
- high risk (1)
- high-resolution tandem mass spectrometry (1)
- hip fracture (1)
- hippocampus (1)
- histological subtype (1)
- histone H2AX (1)
- historical document analysis (1)
- historical printings (1)
- homogeneous catalysis (1)
- homogenization (1)
- honeybee (1)
- honeybees (1)
- hospital exemption (1)
- hospital-acquired methicillin-resistant Staphylococcus aureus (1)
- human adipose-derived stromal cells (1)
- human cerebral endothelial cells (1)
- human plasma (1)
- human xenografted mouse models (1)
- hybrid fabrication (1)
- hybrid materials (1)
- hydroboration (1)
- hydrological regime (1)
- hydroxyapatite (1)
- hydroxylation (1)
- hyperosmolality (1)
- hyperpersonal communication (1)
- hypertension (1)
- hypothermia (1)
- ichthyology (1)
- ichthyosis (1)
- identification (1)
- iliac crest (1)
- illness-death model (1)
- image processing (1)
- imaging PAM (1)
- immediate-early gene (1)
- immune evasion (1)
- immunity (1)
- immunotherapy of cancer (1)
- in vitro (1)
- in vitro model (1)
- in vitro models (1)
- incidence (1)
- indole-3-acetic acid (1)
- indolylpyrimidylpiperazines (1)
- infection biology (1)
- infections (1)
- infectious diseases (1)
- inflammatory gene (1)
- information extraction (1)
- inherited cardiomyopathies (1)
- inhibition (1)
- inhibitor (1)
- injection site reactions (1)
- injury (1)
- inmates (1)
- innate immune evasions (1)
- insect abundance (1)
- insect collection (1)
- insurance medicine (1)
- integrative management strategy (1)
- integrin α2 (1)
- intercomparison (1)
- interface (1)
- interferon beta (1)
- interleukin (1)
- interleukin-6 (1)
- intermediate dose Ara-C (1)
- intermediate filaments (1)
- intermittent exercise (1)
- internal carotid artery stenosis (1)
- intersession experiences (1)
- intersession processes (1)
- interval training (1)
- intestine (1)
- intracellular bacterial pathogens (1)
- intracranial bleeding (1)
- invasive aspergillosis (1)
- inventory (1)
- ionization chambers (1)
- ionization energy (1)
- ionization potential (1)
- iron metabolism (1)
- ischemia reperfusion injury (1)
- ischemia time (1)
- jet shapes (1)
- jet stream (1)
- jets (1)
- keratinocytes (1)
- key structure - fluorescence activation relationships (SFARs) (1)
- kidney (1)
- kinesin (1)
- kinesthesia (1)
- lag effect (1)
- land sharing (1)
- land surface (1)
- land use (1)
- language in media (1)
- late onset sepsis (1)
- late positive potential (1)
- lateral process of the talus (1)
- latewood (1)
- leaf width (1)
- library screening (1)
- lichen planus (1)
- lifestyle (1)
- ligand binding (1)
- ligand-receptor promiscuity (1)
- light-emitting-diodes (1)
- lignan (1)
- lineage-specific genes (1)
- linear conversion (1)
- linguistic cues (1)
- linguistic politics (1)
- lipid metabolism (1)
- liponeurocytoma (1)
- liquid biopsy (1)
- liver (1)
- liver disease (1)
- liver metastases (1)
- local field potentials (1)
- logical trade-offs (1)
- long head of biceps tendon (1)
- long-term potentiation (1)
- loss of function (1)
- low-cost photometer (1)
- lowland beech forests (1)
- luminescence (1)
- lung metastases (1)
- lying (1)
- lymph nodes (1)
- lymphohistiocytosis (1)
- lymphoid tissues (1)
- lyso-phospholipids (1)
- mAb engineering (1)
- mRNA (1)
- mTOR (1)
- macroecology (1)
- macrophage polarization (1)
- macrophages (1)
- magnesium phosphate cement (1)
- maintenance therapy (1)
- major river basins (1)
- management (1)
- manga (1)
- match load (1)
- materials for optics (1)
- maternal separation (1)
- mating (1)
- mating preference (1)
- measurement (1)
- mebendazole (1)
- mechanical performance (1)
- mechanisms of disease (1)
- mechanistic modelling (1)
- medaka (1)
- medical rehabilitation (1)
- medication extraction (1)
- medicinal plant (1)
- medicine (1)
- medieval manuscripts (1)
- medulloblastoma (1)
- melatonin (1)
- melt electrowriting (MEW) (1)
- meningioma (1)
- meningococcal disease (1)
- meningococcus (1)
- mesenchymal stem cell (1)
- mesenchymal stem cells (1)
- mesenchymal stromal cell (1)
- mesentery (1)
- meta-analysis (1)
- metabolic flux (1)
- metabolic modeling (1)
- metabolic modelling (1)
- metabolic switch (1)
- metabolism (1)
- metabolism of infected and uninfected host cells (1)
- metabolomic (1)
- metabolomic profiling (1)
- metal complexenes (1)
- metallo-supramolecular polymer (1)
- metals (1)
- metaproteomics (1)
- metastasis (1)
- metastasis-associated in colon cancer 1 (MACC1) (1)
- methods (1)
- methylation array (1)
- methylprednisolone (1)
- miR-221-5p (1)
- micelles (1)
- micro-chambers (1)
- micro-optics (1)
- microRNA (1)
- microbial rhodopsins (1)
- microbial surface component recognising adhesive matrix molecules (1)
- microbiology (1)
- microbiota (1)
- microfilament (1)
- migrant (1)
- minerals (1)
- minimal residual disease (1)
- minipig (1)
- minocycline (1)
- mitochondrial genome (1)
- mitochondrial mRyR1 (1)
- mitofusin 2 (1)
- mitotic genes (1)
- mixed methods (1)
- mobile app (1)
- mobile health intervention (1)
- model-based diagnosis (1)
- molecular imaging (1)
- molecular neuroscience (1)
- molecular signature (1)
- molecular structures (1)
- molecular subtypes (1)
- monitoring (1)
- monocyte-derived DC (1)
- monotoring (1)
- moonlighting (1)
- motility (1)
- motor aging (1)
- motor-evoked potentials (MEP) (1)
- mouse feeding model (1)
- movement (1)
- mucormycosis (1)
- multi-spectral (1)
- multiresistance (1)
- mutants (1)
- mycophenolic acid (1)
- myelination (1)
- myeloid-derived suppressor cell (MDSC) (1)
- nano-satellite (1)
- nanocomplex (1)
- nanoparticles (1)
- nanophotonics and plasmonics (1)
- nanoscale devices (1)
- nasal mucosal barrier function (1)
- native populations (1)
- natural language processing (1)
- natural pest control (1)
- naturalistic scenes (1)
- naïve B cells (1)
- necroptosis (1)
- neonatal outcome (1)
- neonates (1)
- nerve injury (1)
- nervous system (1)
- nest microbiota (1)
- neume notation (1)
- neural circuits (1)
- neurocytoma (1)
- neurodegenerative disease (1)
- neuroendocrine neoplasms (1)
- neuroendocrine tumors (1)
- neuromuscular disease (1)
- neuronal (1)
- neuronal apoptosis (1)
- neurooncology (1)
- neuropathic pain (1)
- neurotrophic factors (1)
- neurovascular unit (1)
- neutral sphingomyelinase-2 (1)
- neutrinos (1)
- next generation sequencing (1)
- next-generation sequencing (1)
- next-generation-sequencing (1)
- niche (1)
- nicknames (1)
- non-alcoholic fatty liver disease (NAFLD) (1)
- non-alcoholic steatohepatitis (NASH) (1)
- non-invasive fibrosis assessment (1)
- nonalcoholic fatty liver disease (1)
- noncoding RNA (1)
- noncovalent complex (1)
- noncovalent nanocomplex (1)
- normal distribution (1)
- nu SVR (1)
- nuclear envelope (1)
- nuclear export (1)
- number of (1)
- obesity (1)
- obstructive sleep apnoea (1)
- office environment (1)
- office-workers (1)
- oligodendrocyte (1)
- oncogenes (1)
- oncolysis (1)
- oncolytic vaccinia virus (1)
- online dating (1)
- online survey (1)
- ontology (1)
- optical character recognition (1)
- optical materials and structures (1)
- optical music recognition (1)
- optimal drug combination (1)
- optimal drug targeting (1)
- optimal pharmacological modulation (1)
- optimal treatment strategies (1)
- optimization (1)
- optogenetics (1)
- orthoreovirus (1)
- osteochondral defect (1)
- otakuism (1)
- outcome devaluation (1)
- outcomes research (1)
- ovarian cancer (1)
- overuse injury (1)
- oxidative DNA damage (1)
- oxidative stress (1)
- oxindole alkaloids (1)
- p-block element (1)
- p21-activated kinase Mbt/PAK4 (1)
- paediatrics (1)
- pain generator (1)
- panel sequencing (1)
- panic disorder (1)
- panniculitis (1)
- paranodopathy (1)
- parasexual recombination (1)
- parasite biology (1)
- parent-child relationship (1)
- parental perception (1)
- partial agonists (1)
- partial arc (1)
- passive transfer (1)
- patch-clamp (1)
- pathogenesis (1)
- pathogenic bacteria (1)
- patient preference (1)
- patient-based evidence (1)
- patient-reported outcomes (1)
- peatland (1)
- pediatrics (1)
- peer review (1)
- pefloxacin (1)
- peginterferon bet-1a (1)
- pemphigus (1)
- penetration bias (1)
- penumbra (1)
- peptide inhibitor design (1)
- peptidomoics (1)
- performativity (1)
- pericytes (1)
- persistence (1)
- person identity processing (1)
- personality judgments (1)
- perylene bisimide (1)
- perylene bisimides (1)
- pesicicles (1)
- pharmacophore map (1)
- phase transitions and critical phenomena (1)
- phenolic compounds (1)
- phenotypic screening (1)
- phosphorescence (1)
- phosphorescene spectra (1)
- phosphorylation (1)
- photoconductive interlayer (1)
- photodynamic chemotherapy (1)
- photoelectron spectroscopy (1)
- photolysis (1)
- photonic devices (1)
- photophysical prosperties (1)
- photophysics (1)
- physical activity (1)
- physical activity promotion (1)
- physical saliency (1)
- phytic acid (1)
- pi-conjugation (1)
- piRNA (1)
- piscine orthoreovirus (1)
- pit membrane diameter (1)
- placebo and nocebo effects (1)
- plan comparison (1)
- plant reproduction (1)
- plant-derived metabolites (1)
- plants (1)
- plant–microbe–pollinator triangle (1)
- plant–pathogen interaction (1)
- plaque cross-sectional area (1)
- plasma membrane (1)
- plasma membrane depolarization (1)
- plasminogen (1)
- platelet (1)
- platelet degranulation (1)
- platelets (1)
- point shear wave elastography (1)
- pointing task (1)
- pol(2-oxazoline) (1)
- polarimetery (1)
- pollination (1)
- pollination network (1)
- poly(2-oxazine) (1)
- poly(2-oxazoline) (1)
- polycaprolactone (1)
- polyglycerol sulfates (1)
- polynomials (1)
- polyphenols (1)
- population genetics (1)
- position estimation (1)
- positron (1)
- positron annihilation lifetime spectroscopy (1)
- post-fire management (1)
- post-translational modification (1)
- posttranscriptional control (1)
- powerlifting (1)
- pre-B (1)
- precision medicine (1)
- predictive markers (1)
- predictive performance (1)
- premature aging (1)
- presynaptic hyperekplexia (1)
- preterm infants (1)
- primary endpoint (1)
- primary healthcare (1)
- primary immunodeficiency (PID) (1)
- primary outcome (1)
- primary vascular smooth muscle‐like cells (vSMCs) (1)
- pro-B (1)
- probe-based real-time PCR (1)
- procedural learning (1)
- production machines (1)
- prognostic marker (1)
- proliferation (1)
- proliferative darkening syndrome (1)
- prostate cancer (1)
- protected forests (1)
- protein binding (1)
- protein processing (1)
- protein transport (1)
- protein-bound uremic toxins (1)
- protein-protein interaction (PPI) (1)
- proteins (1)
- proteomics (1)
- psychological pain modulation (1)
- psychology (1)
- psychometrics (1)
- psychosocial adaptation (1)
- psychosocial stress (1)
- psychotherapy (1)
- puberty (1)
- pyrolysis (1)
- quality assurance (1)
- quality of democracy (1)
- quality of life (QoL) (1)
- quantile forecasts (1)
- quantitative analysis (1)
- quantum dots (1)
- quantum information (1)
- quantum optics (1)
- qubits (1)
- questionnaires (1)
- radiation (1)
- radiation sensitivity (1)
- radical (1)
- radiopacity (1)
- radiotherapy (1)
- ray (1)
- reaction times (1)
- reactive intermediates (1)
- reactive oxygen species (1)
- real life setting (1)
- real world evidence (1)
- reciprocal translocation (1)
- recombinant tissue-type plasminogen activator (1)
- reconstructive surgery (1)
- rectum (1)
- refractory aGvHD (1)
- registry for primary immunodeficiency (1)
- regulatory T cells (1)
- regulatory T cells (Treg) (1)
- regulatory capital (1)
- regulatory dendritic cells (1)
- reinforcement learning (1)
- reliability (1)
- renal imaging (1)
- repeated sprint (1)
- reprogamming of host cell metabolism (1)
- required hydrophilic–lipophilic balance (1)
- rereading (1)
- resettlement refugees (1)
- resistance (1)
- resonance theory (1)
- restrictive cardiomyopathy (1)
- resveratrol biosynthesis (1)
- retention interval (1)
- reticulate body (1)
- retinal pigment epithelium (1)
- retrospective (1)
- review (1)
- rhBMP–2 (1)
- rheumatic diseases (1)
- rheumatoid arthritis (1)
- rheumatology (1)
- ring-expansion reactions (1)
- ripk1 (1)
- ripk3 (1)
- risk stratification (1)
- robust control (1)
- ruthenium (1)
- saccades (1)
- sacha inchi oil (1)
- sample storage (1)
- saproxylic organisms (1)
- sarcomere (1)
- satellite formation flying (1)
- satellite remote sensing (1)
- scaffold (1)
- screening (1)
- search (1)
- secondary prevention (1)
- secreted effectors (1)
- segmental progeria (1)
- semantic segmentation (1)
- semileptonic & radiative decays (1)
- sensor data (1)
- sensor supports (1)
- sentinel (1)
- sentinel prey (1)
- sepsis (1)
- sequence analysis (1)
- sequential addition (1)
- serial reaction time task (1)
- serotonin (1)
- serotonin deficiency (1)
- setting reaction (1)
- sex robots (1)
- short-range order (1)
- shoulder (1)
- shoulder pain (1)
- shyness (1)
- sigma boranes (1)
- signal specification (1)
- signal transduction (1)
- signalling (1)
- silica supraparticles (1)
- simulation and modeling (1)
- simulation training (1)
- simultaneous presentation paradigm (1)
- single arc (1)
- single photon (1)
- single-molecule tracking (1)
- sirolimus (1)
- skeletal progenitor cells (1)
- skeletal-related events (1)
- skewness (1)
- slope bogs (1)
- small RNAs (1)
- small intestinal submucosa scaffold (1)
- small-cell lung cancer (1)
- smart surfaces (1)
- snowboarder's ankle (1)
- snowboarder's fracture (1)
- soccer (football) (1)
- social anxiety disorder (1)
- social attention (1)
- social behaviour (1)
- sociophonetics (1)
- sodium (1)
- soft tissue sarcoma (1)
- soil fauna (1)
- solar cells (1)
- solid tumors (1)
- solid-state NMR spectroscopy (1)
- solid-state emitters (1)
- solitary bees (1)
- solubility enhancement (1)
- solvent-dependent fluorescence yield (1)
- somatic mutations (1)
- somatosensory evoked potential (1)
- somatosensory temporal discrimination (1)
- spa typing (1)
- spacing effect (1)
- spatial analyses (1)
- spatial heterogeneity (1)
- spatial scale (1)
- species richness (1)
- species‐area hypothesis (1)
- sphingomyelinase (1)
- sphingosine kinase (1)
- sphingosine kinase inhibitor SKI-II (1)
- sphingosine-1-phosphate (1)
- spin polarization (1)
- spin transport (1)
- spinal muscular atrophy (1)
- spleen (1)
- split renal function (1)
- sporidia (1)
- standing (1)
- starPEG hydrogel (1)
- startle response (1)
- static vs. dynamic faces (1)
- statistical distributions (1)
- statistical models (1)
- steering (1)
- stem Cells (1)
- stem cell transplantation (1)
- stereospecific sythesis (1)
- stereotactic body radiation therapy (1)
- stereotactic irradiation (1)
- steric effects (1)
- steroid-resistant aGvHD (1)
- storage-pool diseases (1)
- strength training (1)
- stress (1)
- stress fiber (1)
- stress tolerance (1)
- stromal vascular fraction (1)
- structural disruption (1)
- structure-activity (1)
- structure-activity relationships (1)
- structured illumination microscopy (1)
- subadditivity (1)
- subarachnoid hemorrhage (1)
- submicroscopic chromosome rearrangement (1)
- subsarcolemmal mitochondria (1)
- substituent (1)
- subsurface hydrology (1)
- subthalamic nucleus (1)
- sulfoimines (1)
- sulfur (1)
- super resolution microscopy (1)
- super-resolution microscopy (1)
- superresolution (1)
- suppressor mutation (1)
- surface transport (1)
- surface water (1)
- surfaces, interfaces and thin films (1)
- surgical and invasive medical procedures (1)
- surgical site infection (1)
- survival analysis (1)
- synchrotron radiation (1)
- synchrotron radiatoren (1)
- synergistic effect (1)
- synthesis (1)
- systematic affiliation (1)
- targeted bisulfite sequencing (1)
- targeted therapies (1)
- targeted therapy (1)
- taxonomy (1)
- temozolomide (1)
- temperature‐mediated resource exploitation hypothesis (1)
- temperature‐richness hypothesis (1)
- temporal discrimination threshold (1)
- temporal lobe epilepsy (1)
- tendon-derived stem cell (1)
- terrestrial LiDAR (1)
- theranostics (1)
- therapy (1)
- therapy response (1)
- thermal remote sensing (1)
- thrombo-inflammation (1)
- thrombolysis (tPA) (1)
- thrombosis (1)
- tight junctions (1)
- time lag (1)
- time series (1)
- tisindoline (1)
- top-down processing (1)
- topminnow (1)
- topological insulators (1)
- topological matter (1)
- total body irradiation/busulfan (1)
- toxicity (1)
- transcranial magnetic simulation (TMS) (1)
- transcription (1)
- transcription deficiency (1)
- transcriptomics (1)
- transient dynamics (1)
- transient elastography (1)
- transient ischemic attack (1)
- transient middle cerebral artery occlusion (1)
- transition metal (1)
- transmission (1)
- transplantation (1)
- transposable elements (1)
- treatment (1)
- tree cavities (1)
- triacylglycerides (1)
- triarylboranes (1)
- triple bonds (1)
- trivalent boron (1)
- trypanosomes (1)
- tryptophan hydroxylase 2 (1)
- tumor burden (1)
- tumor control probability (1)
- tumor heterogeneity (1)
- tumor suppressor miRNA (1)
- tumour-necrosis factors (1)
- two-photon absorption (1)
- tyloses (1)
- type VII secretion system (1)
- ubiquitin ligase (1)
- ubiquitylation (ubiquitination) (1)
- uncanny valley (1)
- uncertainties (1)
- uncertainty (1)
- uneven-aged mountainous (1)
- unmanaged broadleaved forests (1)
- unsaturated fatty acids (1)
- upconversion (1)
- uptake (1)
- urban environments (1)
- uremic toxins (1)
- urinary tract infections (1)
- vaccinia (1)
- variability (1)
- vasculitis (1)
- vertebral body (1)
- vertical and radial variation (1)
- very high energies (VHE) (1)
- very long-chain aliphatic compounds (1)
- vessel lumen diameter (1)
- vestibular schwannoma (1)
- video laryngoscopy (1)
- virotherapy (1)
- virtual isocenter (1)
- viruses (1)
- visual orientation (1)
- visual perception (1)
- visual realism (1)
- vitamin D (1)
- vitamins (1)
- voice-face matching (1)
- volume overload (1)
- voxel-based morphometry (1)
- walking (1)
- water balance (1)
- watershed (1)
- weightlifting (1)
- well-being (1)
- white matter lesions (1)
- whole-genome duplication (1)
- whole-genome sequencing (1)
- wild bees (1)
- wood anatomy (1)
- work (1)
- work capacity evaluation (1)
- work engagement (1)
- work performance (1)
- wound healing (1)
- youth (1)
- zinc oxide (1)
- zinc oxide nanoparticles (1)
- zonal construct (1)
Institute
- Theodor-Boveri-Institut für Biowissenschaften (81)
- Medizinische Klinik und Poliklinik II (32)
- Physikalisches Institut (30)
- Neurologische Klinik und Poliklinik (23)
- Institut für Psychologie (22)
- Institut für Anorganische Chemie (19)
- Institut für Geographie und Geologie (18)
- Rudolf-Virchow-Zentrum (18)
- Institut für Hygiene und Mikrobiologie (17)
- Medizinische Klinik und Poliklinik I (17)
Sonstige beteiligte Institutionen
- Department of Hematology and Oncology, Sana Hospital Hof, Hof, Germany (1)
- Department of Laboratory Medicine and Medicine Huddinge, Karolinska Institutet and University Hospital, Stockholm, Sweden (1)
- Department of Medicine A, University Hospital of Münster, Münster, Germany (1)
- IZKF Nachwuchsgruppe Geweberegeneration für muskuloskelettale Erkrankungen (1)
- Interdisciplinary Center for Clinical Research (1)
- Johns Hopkins School of Medicine (1)
- University of Bari Medical School, Bari, Italy (1)
Besides external characteristics and reading a piece of DNA (barcode), the DNA weight per nucleus (genome size) via flow cytometry is a key value to detect species and hybrids and determine ploidy. In addition, the DNA weight appears to be related to various properties, such as the size of the cell and the nucleus, the duration of mitosis and meiosis and the generation time. Sometimes it is even possible to distinguish between groups or sections, which can lead to new classification of the genera. The variation in DNA weight is also useful to analyze biodiversity, genome evolution and relationships between related taxa. Moreover, it is important to know how large a genome is before one determines the base sequence of the DNA of a plant. Flow cytometry is also important for understanding fundamental processes in plants such as growth and development and recognizing chimeras. In the literature, DNA weight measurements are usually limited to one genus and often only locally (Siljak et al. 2010; Bai et al. 2012). In this study, however, it was decided to investigate all vascular plants from one country. This can also contribute to the protection of rare plants. This study is the first flora in the world whose weight of DNA per nucleus and peak patterns has been determined. More than 6400 plants, representing more than 2350 (sub)species (more than 90%) have been collected, thanks to the help of almost 100 volunteers of Floristisch Onderzoek Nederland (Floron). Multiple specimens of many species have therefore been measured, preferably from different populations, in some cases more than fifty. For 1370 species, these values were not previously published. Moreover, a good number of the remaining 45% are new for The Netherlands. In principle, each species has a fixed weight of DNA per nucleus. It has also been found that, especially between the genera, there are strong differences in the number of peaks that determine the DNA weight, from one to five peaks. This indicates that in a plant or organ there are sometimes nuclei with multiples of its standard DNA weight (multiple ploidy levels). It is impossible to show graphs of more than 2350 species. Therefore, we have chosen to show the peak pattern in a new way in a short formula. Within most genera there are clear differences in the DNA weights per nucleus between the species, in some other genera the DNA weight is hardly variable. Based on about twenty genera that were previously measured completely in most cases (‘t Hart et al. 2003: Veldkamp and Zonneveld 2011; Soes et al. 2012; Dirkse et al. 2014, 2015; Verloove et al. 2017; Zonneveld [et al.] 2000−2018), it can be noted that even if all species of a genus have the same number of chromosomes, there can still be a difference of up to three times in the weight of the DNA. Therefore, a twice larger DNA weight does not have to indicate four sets of chromosomes. Finally, this research has also found clues to examine further the current taxonomy of a number of species or genera.
Background
Causality between hepatitis B virus (HBV) infection and diffuse large B-cell lymphoma (DLBCL) was reported in various studies. However, the implication of different virological serum markers of HBV infection in patients with both HBV infection and DLBCL is not fully understood. The aim of this study was to investigate the impact of HBV markers on overall survival (OS) and progression-free survival (PFS) in patients with both HBV infection and DLBCL.
Methods
In this study, patients (n = 40) diagnosed with both HBV infection and DLBCL were identified between 2000 and 2017. Six patients with hepatitis C virus (HCV) and/or human immunodeficiency virus (HIV) co-infection were excluded from this study. We retrospectively analyzed patients’ demographic characteristics, treatment, and the prognostic impact of different HBV markers at first diagnosis of DLBCL (HBsAg, anti-HBs, HBeAg, anti-HBe, and HBV-DNA) on OS and PFS.
Results
The majority of patients (n = 21, 62%) had advanced disease stage (III/IV) at diagnosis. In the first-line therapy, 24 patients (70%) were treated with R-CHOP regimen (rituximab, cyclophosphamide, hydroxydaunorubicin, vincristine, and prednisolone). HBeAg positive patients had a trend toward inferior OS and PFS compared with HBeAg negative patients. Anti-HBe positive patients had a statistically significant better OS and PFS compared with anti-HBe negative group (both P < .0001). Viremia with HBV-DNA ≥ 2 × 107 IU/L had a significant negative impact on OS and PFS (both P < .0001).
Conclusion
High activity of viral replication is associated with a poor survival outcome of patients with both HBV infection and DLBCL.
Polygonum cuspidatum (Japanese knotweed, also known as Huzhang in Chinese), a plant that produces bioactive components such as stilbenes and quinones, has long been recognized as important in traditional Chinese herbal medicine. To better understand the biological features of this plant and to gain genetic insight into the biosynthesis of its natural products, we assembled a draft genome of P. cuspidatum using Illumina sequencing technology. The draft genome is ca. 2.56 Gb long, with 71.54% of the genome annotated as transposable elements. Integrated gene prediction suggested that the P. cuspidatum genome encodes 55,075 functional genes, including 6,776 gene families that are conserved in the five eudicot species examined and 2,386 that are unique to P. cuspidatum. Among the functional genes identified, 4,753 are predicted to encode transcription factors. We traced the gene duplication history of P. cuspidatum and determined that it has undergone two whole-genome duplication events about 65 and 6.6 million years ago. Roots are considered the primary medicinal tissue, and transcriptome analysis identified 2,173 genes that were expressed at higher levels in roots compared to aboveground tissues. Detailed phylogenetic analysis demonstrated expansion of the gene family encoding stilbene synthase and chalcone synthase enzymes in the phenylpropanoid metabolic pathway, which is associated with the biosynthesis of resveratrol, a pharmacologically important stilbene. Analysis of the draft genome identified 7 abscisic acid and water deficit stress-induced protein-coding genes and 14 cysteine-rich transmembrane module genes predicted to be involved in stress responses. The draft de novo genome assembly produced in this study represents a valuable resource for the molecular characterization of medicinal compounds in P. cuspidatum, the improvement of this important medicinal plant, and the exploration of its abiotic stress resistance.
Stereospecific Synthesis and Photophysical Properties of Propeller-Shaped C\(_{90}\)H\(_{48}\) PAH
(2019)
Herein, we have synthesized an enantiomerically pure propeller‐shaped PAH, C\(_{90}\)H\(_{48}\), possessing three [7]helicene and three [5]helicene subunits. This compound can be obtained in gram quantities in a straightforward manner. The photophysical and chiroptical properties were investigated using UV/Vis absorption and emission, optical rotation and circular dichroism spectroscopy, supported by DFT calculations. The nonlinear optical properties were investigated by two‐photon absorption measurements using linearly and circularly polarized light. The extremely twisted structure and packing of the homochiral compound were investigated by single‐crystal X‐ray diffraction analysis.
Background
Almost 90% of cancer patients suffer from symptoms of fatigue during treatment. Supporting treatments are increasingly used to alleviate the burden of fatigue. This study examines the short-term and long-term effects of yoga on fatigue and the effect of weekly reminder e-mails on exercise frequency and fatigue symptoms.
Methods
The aim of the first part of the study will evaluate the effectiveness of yoga for cancer patients with mixed diagnoses reporting fatigue. We will randomly allocate 128 patients to an intervention group (N = 64) receiving yoga and a wait-list control group (N = 64) receiving yoga 9 weeks later. The yoga therapy will be performed in weekly sessions of 60 min each for 8 weeks. The primary outcome will be self-reported fatigue symptoms. In the second part of the study, the effectiveness of reminder e-mails with regard to the exercise frequency and self-reported fatigue symptoms will be evaluated. A randomized allocated group of the participants (“email”) receives weekly reminder e-mails, the other group does not. Data will be assessed using questionnaires the beginning and after yoga therapy as well as after 6 months.
Discussion
Support of patients suffering from fatigue is an important goal in cancer patients care. If yoga therapy will reduce fatigue, this type of therapy may be introduced into routine practice. If the reminder e-mails prove to be helpful, new offers for patients may also develop from this.
The green synthesis of silver nanoparticles (SNPs) using plant extracts is an eco-friendly method. It is a single step and offers several advantages such as time reducing, cost-effective and environmental non-toxic. Silver nanoparticles are a type of Noble metal nanoparticles and it has tremendous applications in the field of diagnostics, therapeutics, antimicrobial activity, anticancer and neurodegenerative diseases. In the present work, the aqueous extracts of aerial parts of Lampranthus coccineus and Malephora lutea F. Aizoaceae were successfully used for the synthesis of silver nanoparticles. The formation of silver nanoparticles was early detected by a color change from pale yellow to reddish-brown color and was further confirmed by transmission electron microscope (TEM), UV–visible spectroscopy, Fourier transform infrared (FTIR) spectroscopy, dynamic light scattering (DLS), X-ray diffraction (XRD), and energy-dispersive X-ray diffraction (EDX). The TEM analysis of showed spherical nanoparticles with a mean size between 12.86 nm and 28.19 nm and the UV- visible spectroscopy showed λ\(_{max}\) of 417 nm, which confirms the presence of nanoparticles. The neuroprotective potential of SNPs was evaluated by assessing the antioxidant and cholinesterase inhibitory activity. Metabolomic profiling was performed on methanolic extracts of L. coccineus and M. lutea and resulted in the identification of 12 compounds, then docking was performed to investigate the possible interaction between the identified compounds and human acetylcholinesterase, butyrylcholinesterase, and glutathione transferase receptor, which are associated with the progress of Alzheimer’s disease. Overall our SNPs highlighted its promising potential in terms of anticholinesterase and antioxidant activity as plant-based anti-Alzheimer drug and against oxidative stress.
Metabolic adaptation to the host cell is important for obligate intracellular pathogens such as Chlamydia trachomatis (Ct). Here we infer the flux differences for Ct from proteome and qRT-PCR data by comprehensive pathway modeling. We compare the comparatively inert infectious elementary body (EB) and the active replicative reticulate body (RB) systematically using a genome-scale metabolic model with 321 metabolites and 277 reactions. This did yield 84 extreme pathways based on a published proteomics dataset at three different time points of infection. Validation of predictions was done by quantitative RT-PCR of enzyme mRNA expression at three time points. Ct’s major active pathways are glycolysis, gluconeogenesis, glycerol-phospholipid (GPL) biosynthesis (support from host acetyl-CoA) and pentose phosphate pathway (PPP), while its incomplete TCA and fatty acid biosynthesis are less active. The modeled metabolic pathways are much more active in RB than in EB. Our in silico model suggests that EB and RB utilize folate to generate NAD(P)H using independent pathways. The only low metabolic flux inferred for EB involves mainly carbohydrate metabolism. RB utilizes energy -rich compounds to generate ATP in nucleic acid metabolism. Validation data for the modeling include proteomics experiments (model basis) as well as qRT-PCR confirmation of selected metabolic enzyme mRNA expression differences. The metabolic modeling is made fully available here. Its detailed insights and models on Ct metabolic adaptations during infection are a useful modeling basis for future studies.
Organoids derived from human pluripotent stem cells are interesting models to study mechanisms of morphogenesis and promising platforms for disease modeling and drug screening. However, they mostly remain incomplete as they lack stroma, tissue resident immune cells and in particular vasculature, which create important niches during development and disease. We propose, that the directed incorporation of mesodermal progenitor cells (MPCs) into organoids will overcome the aforementioned limitations. In order to demonstrate the feasibility of the method, we generated complex human tumor as well as neural organoids. We show that the formed blood vessels display a hierarchic organization and mural cells are assembled into the vessel wall. Moreover, we demonstrate a typical blood vessel ultrastructure including endothelial cell-cell junctions, a basement membrane as well as luminal caveolae and microvesicles. We observe a high plasticity in the endothelial network, which expands, while the organoids grow and is responsive to anti-angiogenic compounds and pro-angiogenic conditions such as hypoxia. We show that vessels within tumor organoids connect to host vessels following transplantation. Remarkably, MPCs also deliver Iba1\(^+\) cells that infiltrate the neural tissue in a microglia-like manner.
Background
Atrial fibrillation (AF) is present in 15–20% of patients with acute ischemic stroke. Oral anticoagulation reduces the risk of AF-related recurrent stroke but clinical guideline recommendations are rather vague regarding its use in the acute phase of stroke. We aimed to assess the current clinical practice of medical stroke prevention in AF patients during the acute phase of ischemic stroke.
Methods
In April 2017, a standardized anonymous questionnaire was sent to clinical leads of all 298 certified stroke units in Germany.
Results
Overall, 154 stroke unit leads participated (response rate 52%). Anticoagulation in the acute phase of stroke is considered feasible in more than 90% of AF patients with ischemic stroke. Clinicians assume that about two thirds of all AF patients (range 20–100%) are discharged on oral anticoagulation. According to local preferences, acetylsalicylic acid is given orally in the majority of patients with delayed initiation of oral anticoagulation. A non-vitamin K-dependent oral anticoagulant (NOAC) is more often prescribed than a vitamin K-dependent oral anticoagulant (VKA). VKA is more often chosen in patients with previous VKA intake than in VKA naive patients. In the minority of patients, stroke unit leads discuss the prescription of a specific oral anticoagulant with the treating general practitioner. Adherence to medical stroke prevention after hospital discharge is not assessed on a regular basis in any patient by the majority of participating stroke centers.
Conclusions
Early secondary stroke prevention in AF patients in German stroke units is based on OAC use but prescription modalities vary in clinical practice.
The synthetic compound dendritic polyglycerol sulfate (dPGS) is a pleiotropic acting molecule but shows a high binding affinity to immunological active molecules as L‐/P‐selectin or complement proteins leading to well described anti‐inflammatory properties in various mouse models. In order to make a comprehensive evaluation of the direct effect on the innate immune system, macrophage polarization is analyzed in the presence of dPGS on a phenotypic but also metabolic level. dPGS administered macrophages show a significant increase of MCP1 production paralleled by a reduction of IL‐10 secretion. Metabolic analysis reveals that dPGS could potently enhance the glycolysis and mitochondrial respiration in M0 macrophages as well as decrease the mitochondrial respiration of M2 macrophages. In summary the data indicate that dPGS polarizes macrophages into a pro‐inflammatory phenotype in a metabolic pathway‐dependent manner.
How insects promote crop pollination remains poorly understood in terms of the contribution of functional trait differences between species. We used meta-analyses to test for correlations between community abundance, species richness and functional trait metrics with oilseed rape yield, a globally important crop. While overall abundance is consistently important in predicting yield, functional divergence between species traits also showed a positive correlation. This result supports the complementarity hypothesis that pollination function is maintained by non-overlapping trait distributions. In artificially constructed communities (mesocosms), species richness is positively correlated with yield, although this effect is not seen under field conditions. As traits of the dominant species do not predict yield above that attributed to the effect of abundance alone, we find no evidence in support of the mass ratio hypothesis. Management practices increasing not just pollinator abundance, but also functional divergence, could benefit oilseed rape agriculture.
Elucidating the mechanism of action of domatinostat (4SC-202) in cutaneous T cell lymphoma cells
(2019)
Background
Targeting epigenetic modifiers is effective in cutaneous T cell lymphoma (CTCL). However, there is a need for further improvement of this therapeutic approach. Here, we compared the mode of action of romidepsin (FK228), an established class I histone deacetylase inhibitor, and domatinostat (4SC-202), a novel inhibitor of class I HDACs, which has been reported to also target the lysine-specific histone demethylase 1A (LSD1).
Methods
We performed MTS assays and flow cytometric analyses of propidium iodide or annexin V-stained cells to assess drug impact on cellular proliferation, cell cycle distribution, and survival. Histone acetylation and methylation as well as caspase activation was analyzed by immunoblot. Gene expression analysis was performed using NanosString technology. Knockdown and knockout of LSD1 was achieved with shRNA and CRISPR/Cas9, respectively, while the CRISPR/Cas9 synergistic activation mediator system was used to induce expression of endogenous HDACs and LSD1. Furthermore, time-lapse fluorescence microscopy and an in vitro tubulin polymerization assay were applied.
Results
While FK228 as well as 4SC-202 potently induced cell death in six different CTCL cell lines, only in the case of 4SC-202 death was preceded by an accumulation of cells in the G2/M phase of the cell cycle. Surprisingly, apoptosis and accumulation of cells with double DNA content occurred already at 4SC-202 concentrations hardly affecting histone acetylation and methylation, and provoking significantly less changes in gene expression compared to biologically equivalent doses of FK228. Indeed, we provide evidence that the 4SC-202-induced G2/M arrest in CTCL cells is independent of de novo transcription. Furthermore, neither enforced expression of HDAC1 nor knockdown or knockout of LSD1 affected the 4SC-202-induced effects. Since time-lapse microscopy revealed that 4SC-202 could affect mitotic spindle formation, we performed an in vitro tubulin polymerization assay revealing that 4SC-202 can directly inhibit microtubule formation.
Conclusions
We demonstrate that 4SC-202, a drug currently tested in clinical trials, effectively inhibits growth of CTCL cells. The anti-cancer cell activity of 4SC-202 is however not limited to LSD1-inhibition, modulation of histone modifications, and consecutive alteration of gene expression. Indeed, the compound is also a potent microtubule-destabilizing agent.
The detection of toxic gases, such as NH\(_{3}\) and CO, in the environment is of high interest in chemical, electronic, and automotive industry as even small amounts can display a health risk for workers. Sensors for the real‐time monitoring of these gases should be simple, robust, reversible, highly sensitive, inexpensive and show a fast response. The indicator supraparticles presented herein can fulfill all of these requirements. They consist of silica nanoparticles, which are assembled to supraparticles upon spray‐drying. Sensing molecules such as Reichardt's dye and a binuclear rhodium complex are loaded onto the microparticles to target NH\(_{3}\) and CO detection, respectively. The spray‐drying technique affords high flexibility in primary nanoparticle size selection and thus, easy adjustment of the porosity and specific surface area of the obtained micrometer‐sized supraparticles. This ultimately enables the fine‐tuning of the sensor sensitivity and response. For the application of the indicator supraparticles in a gas detection device, they can be immobilized on a coating. Due to their microscale size, they are large enough to poke out of thin coating layers, thus guaranteeing their gas accessibility, while being small enough to be applicable to flexible substrates.
Purpose
4D flow cardiovascular magnetic resonance (CMR) and the assessment of wall shear stress (WSS) are non-invasive tools to study cardiovascular risks in vivo. Major limitations of conventional triggered methods are the long measurement times needed for high-resolution data sets and the necessity of stable electrocardiographic (ECG) triggering. In this work an ECG-free retrospectively synchronized method is presented that enables accelerated high-resolution measurements of 4D flow and WSS in the aortic arch of mice.
Methods
4D flow and WSS were measured in the aortic arch of 12-week-old wildtype C57BL/6 J mice (n = 7) with a radial 4D-phase-contrast (PC)-CMR sequence, which was validated in a flow phantom. Cardiac and respiratory motion signals were extracted from the radial CMR signal and were used for the reconstruction of 4D-flow data. Rigid motion correction and a first order B0 correction was used to improve the robustness of magnitude and velocity data.
The aortic lumen was segmented semi-automatically. Temporally averaged and time-resolved WSS and oscillatory shear index (OSI) were calculated from the spatial velocity gradients at the lumen surface at 14 locations along the aortic arch. Reproducibility was tested in 3 animals and the influence of subsampling was investigated.
Results
Volume flow, cross-sectional areas, WSS and the OSI were determined in a measurement time of only 32 min. Longitudinal and circumferential WSS and radial stress were assessed at 14 analysis planes along the aortic arch. The average longitudinal, circumferential and radial stress values were 1.52 ± 0.29 N/m2, 0.28 ± 0.24 N/m2 and − 0.21 ± 0.19 N/m2, respectively. Good reproducibility of WSS values was observed.
Conclusion
This work presents a robust measurement of 4D flow and WSS in mice without the need of ECG trigger signals. The retrospective approach provides fast flow quantification within 35 min and a flexible reconstruction framework.
Background
Epigenetic mechanisms may play a major role in the biological embedding of early-life stress (ELS). One proposed mechanism is that glucocorticoid (GC) release following ELS exposure induces long-lasting alterations in DNA methylation (DNAm) of important regulatory genes of the stress response. Here, we investigate the dynamics of GC-dependent methylation changes in key regulatory regions of the FKBP5 locus in which ELS-associated DNAm changes have been reported.
Results
We repeatedly measured DNAm in human peripheral blood samples from 2 independent cohorts exposed to the GC agonist dexamethasone (DEX) using a targeted bisulfite sequencing approach, complemented by data from Illumina 450K arrays. We detected differentially methylated CpGs in enhancers co-localizing with GC receptor binding sites after acute DEX treatment (1 h, 3 h, 6 h), which returned to baseline levels within 23 h. These changes withstood correction for immune cell count differences. While we observed main effects of sex, age, body mass index, smoking, and depression symptoms on FKBP5 methylation levels, only the functional FKBP5 SNP (rs1360780) moderated the dynamic changes following DEX. This genotype effect was observed in both cohorts and included sites previously shown to be associated with ELS.
Conclusion
Our study highlights that DNAm levels within regulatory regions of the FKBP5 locus show dynamic changes following a GC challenge and suggest that factors influencing the dynamics of this regulation may contribute to the previously reported alterations in DNAm associated with current and past ELS exposure.
Even today, the automatic digitisation of scanned documents in general, but especially the automatic optical music recognition (OMR) of historical manuscripts, still remains an enormous challenge, since both handwritten musical symbols and text have to be identified. This paper focuses on the Medieval so-called square notation developed in the 11th–12th century, which is already composed of staff lines, staves, clefs, accidentals, and neumes that are roughly spoken connected single notes. The aim is to develop an algorithm that captures both the neumes, and in particular its melody, which can be used to reconstruct the original writing. Our pipeline is similar to the standard OMR approach and comprises a novel staff line and symbol detection algorithm based on deep Fully Convolutional Networks (FCN), which perform pixel-based predictions for either staff lines or symbols and their respective types. Then, the staff line detection combines the extracted lines to staves and yields an F\(_1\) -score of over 99% for both detecting lines and complete staves. For the music symbol detection, we choose a novel approach that skips the step to identify neumes and instead directly predicts note components (NCs) and their respective affiliation to a neume. Furthermore, the algorithm detects clefs and accidentals. Our algorithm predicts the symbol sequence of a staff with a diplomatic symbol accuracy rate (dSAR) of about 87%, which includes symbol type and location. If only the NCs without their respective connection to a neume, all clefs and accidentals are of interest, the algorithm reaches an harmonic symbol accuracy rate (hSAR) of approximately 90%. In general, the algorithm recognises a symbol in the manuscript with an F\(_1\) -score of over 96%.
FinO domain proteins such as ProQ of the model pathogen Salmonella enterica have emerged as a new class of major RNA-binding proteins in bacteria. ProQ has been shown to target hundreds of transcripts, including mRNAs from many virulence regions, but its role, if any, in bacterial pathogenesis has not been studied. Here, using a Dual RNA-seq approach to profile ProQ-dependent gene expression changes as Salmonella infects human cells, we reveal dysregulation of bacterial motility, chemotaxis, and virulence genes which is accompanied by altered MAPK (mitogen-activated protein kinase) signaling in the host. Comparison with the other major RNA chaperone in Salmonella, Hfq, reinforces the notion that these two global RNA-binding proteins work in parallel to ensure full virulence. Of newly discovered infection-associated ProQ-bound small noncoding RNAs (sRNAs), we show that the 3′UTR-derived sRNA STnc540 is capable of repressing an infection-induced magnesium transporter mRNA in a ProQ-dependent manner. Together, this comprehensive study uncovers the relevance of ProQ for Salmonella pathogenesis and highlights the importance of RNA-binding proteins in regulating bacterial virulence programs.
IMPORTANCE
The protein ProQ has recently been discovered as the centerpiece of a previously overlooked “third domain” of small RNA-mediated control of gene expression in bacteria. As in vitro work continues to reveal molecular mechanisms, it is also important to understand how ProQ affects the life cycle of bacterial pathogens as these pathogens infect eukaryotic cells. Here, we have determined how ProQ shapes Salmonella virulence and how the activities of this RNA-binding protein compare with those of Hfq, another central protein in RNA-based gene regulation in this and other bacteria. To this end, we apply global transcriptomics of pathogen and host cells during infection. In doing so, we reveal ProQ-dependent transcript changes in key virulence and host immune pathways. Moreover, we differentiate the roles of ProQ from those of Hfq during infection, for both coding and noncoding transcripts, and provide an important resource for those interested in ProQ-dependent small RNAs in enteric bacteria.
We aimed to determine a detailed regional ventricular distribution pattern of the novel cardiac nerve PET radiotracer \(^{18}\)F-LMI1195 in healthy rabbits. Ex-vivo high resolution autoradiographic imaging was conducted to identify accurate ventricular distribution of \(^{18}\)F-LMI1195. In healthy rabbits, \(^{18}\)F-LMI1195 was administered followed by the reference perfusion marker \(^{201}\)Tl for a dual-radiotracer analysis. After 20 min of \(^{18}\)F-LMI1195 distribution time, the rabbits were euthanized, the hearts were extracted, frozen, and cut into 20-μm short axis slices. Subsequently, the short axis sections were exposed to a phosphor imaging plate to determine \(^{18}\)F-LMI1195 distribution (exposure for 3 h). After complete \(^{18}\)F decay, sections were re-exposed to determine 201Tl distribution (exposure for 7 days). For quantitative analysis, segmental regions of Interest (ROIs) were divided into four left ventricular (LV) and a right ventricular (RV) segment on mid-ventricular short axis sections. Subendocardial, mid-portion, and subepicardial ROIs were placed on the LV lateral wall. \(^{18}\)F-LMI1195 distribution was almost homogeneous throughout the LV wall without any significant differences in all four LV ROIs (anterior, posterior, septal and lateral wall, 99 ± 2, 94 ± 5, 94 ± 4 and 97 ± 3%LV, respectively, n.s.). Subepicardial \(^{201}\)Tl uptake was significantly lower compared to the subendocardial portion (subendocardial, mid-portion, and subepicardial activity: 90 ± 3, 96 ± 2 and *80 ± 5%LV, respectively, *p < 0.01 vs. mid-portion). This was in contradistinction to the transmural wall profile of \(^{18}\)F-LMI1195 (90 ± 4, 96 ± 5 and 84 ± 4%LV, n.s.). A slight but significant discrepant transmural radiotracer distribution pattern of \(^{201}\)Tl in comparison to \(^{18}\)F-LMI1195 may be a reflection of physiological sympathetic innervation and perfusion in rabbit hearts.
The novel PET probe 2-deoxy-2-18F-fluoro-D-sorbitol (18F-FDS) has demonstrated favorable renal kinetics in animals. We aimed to elucidate its imaging properties in two human volunteers. 18F-FDS was produced by a simple one-step reduction from 18F-FDG. On dynamic renal PET, the cortex was delineated and activity gradually transited in the parenchyma, followed by radiotracer excretion. No adverse effects were reported. Given the higher spatiotemporal resolution of PET relative to conventional scintigraphy, 18F-FDS PET offers a more thorough evaluation of human renal kinetics. Due to its simple production from 18F-FDG, 18F-FDS is virtually available at any PET facility with radiochemistry infrastructure.
Despite histological evidence in various solid tumor entities, available experience with CXCR4-directed diagnostics and endoradiotherapy mainly focuses on hematologic diseases. With the goal of expanding the application of CXCR4 theranostics to solid tumors, we aimed to elucidate the feasibility of CXCR4-targeted imaging in a variety of such neoplasms.
Methods: Nineteen patients with newly diagnosed, treatment-naïve solid tumors including pancreatic adenocarcinoma or neuroendocrine tumor, cholangiocarcinoma, hepatocellular carcinoma, renal cell carcinoma, ovarian cancer, and prostate cancer underwent [\(^{68}\)Ga]Pentixafor PET/CT. CXCR4-mediated uptake was assessed both visually and semi-quantitatively by evaluation of maximum standardized uptake values (SUV\(_{max}\)) of both primary tumors and metastases. With physiologic liver uptake as reference, tumor-to-background ratios (TBR) were calculated. [\(^{68}\)Ga]Pentixafor findings were further compared to immunohistochemistry and [\(^{18}\)F]FDG PET/CT.
Results: On [\(^{68}\)Ga]Pentixafor PET/CT, 10/19 (52.6%) primary tumors were visually detectable with a median SUVmax of 5.4 (range, 1.7–16.0) and a median TBR of 2.6 (range, 0.8–7.4), respectively. The highest level of radiotracer uptake was identified in a patient with cholangiocarcinoma (SUVmax, 16.0; TBR, 7.4). The relatively low uptake on [\(^{68}\)Ga]Pentixafor was also noted in metastases, exhibiting a median SUVmax of 4.5 (range, 2.3–8.8; TBR, 1.7; range, 1.0–4.1). A good correlation between uptake on [\(^{68}\)Ga]Pentixafor and histological derived CXCR4 expression was noted (R = 0.62, P < 0.05). In the 3 patients in whom [\(^{18}\)F]FDG PET/CT was available, [\(^{68}\)Ga]Pentixafor exhibited lower uptake in all lesions.
Conclusions: In this cohort of newly diagnosed, treatment-naïve patients with solid malignancies, CXCR4 expression as detected by [\(^{68}\)Ga]Pentixafor-PET/CT and immunohistochemistry was rather moderate. Thus, CXCR4-directed imaging may not play a major role in the management of solid tumors in the majority of patients.