Refine
Year of publication
- 2014 (903) (remove)
Document Type
- Journal article (446)
- Doctoral Thesis (365)
- Complete part of issue (49)
- Review (9)
- Working Paper (8)
- Study Thesis (term paper) (7)
- Book article / Book chapter (5)
- Conference Proceeding (3)
- Preprint (3)
- Book (2)
Keywords
- Würzburg (48)
- University (47)
- Universität (47)
- Wuerzburg (47)
- Wurzburg (47)
- gene expression (12)
- Maus (11)
- T-Lymphozyt (10)
- expression (10)
- Rezension (8)
- apoptosis (7)
- cancer (7)
- metabolism (7)
- phosphorylation (7)
- Apoptosis (6)
- Genexpression (6)
- Thrombozyt (6)
- Transkriptionsfaktor (6)
- escherichia coli (6)
- flow cytometry (6)
- lymphoma (6)
- Archäologie (5)
- antibodies (5)
- cytokines (5)
- cytoskeleton (5)
- dendritic cells (5)
- disease (5)
- gene (5)
- immune response (5)
- in-vitro (5)
- infection (5)
- mice (5)
- proliferation (5)
- protein (5)
- stroke (5)
- virulence (5)
- Ackerschmalwand (4)
- Angiogenese (4)
- B cells (4)
- Dendritische Zelle (4)
- Deutschland (4)
- EEG (4)
- Epigenetik (4)
- Germany (4)
- HIV (4)
- Kernspintomographie (4)
- MRI (4)
- Regulation (4)
- Spintronik (4)
- T cells (4)
- Taufliege (4)
- Tissue Engineering (4)
- Topologischer Isolator (4)
- activation (4)
- blood pressure (4)
- body mass index (4)
- brain (4)
- breast cancer (4)
- cancer treatment (4)
- cell staining (4)
- cells (4)
- children (4)
- fMRI (4)
- immunoprecipitation (4)
- in-vivo (4)
- inflammation (4)
- ischemic stroke (4)
- messenger RNA (4)
- miRNS (4)
- microarray (4)
- molecular docking (4)
- oxidative stress (4)
- platelets (4)
- survival (4)
- therapy (4)
- traumatic brain injury (4)
- ADHD (3)
- Antikörper (3)
- Arteriosklerose (3)
- Aufmerksamkeits-Defizit-Syndrom (3)
- Biodiversität (3)
- Bioinformatik (3)
- Calcium (3)
- Climate Change (3)
- Computational chemistry (3)
- Data Mining (3)
- Diagnostik (3)
- ERP (3)
- Echinococcus (3)
- Entzündung (3)
- Escherichia coli (3)
- Essgewohnheit (3)
- Essverhalten (3)
- Galliumarsenid (3)
- Herzfrequenzvariabilität (3)
- Historische Aufnahme (3)
- Inflammation (3)
- Inhibitor (3)
- Jugend (3)
- Kernspintomografie (3)
- Klimaänderung (3)
- Leistungsbewertung (3)
- Molekularbiologie (3)
- Monoklonaler Antikörper (3)
- Myc (3)
- NF-KAPPA-B (3)
- Netzwerk (3)
- Organische Solarzelle (3)
- Organischer Halbleiter (3)
- Polymere (3)
- Positronen-Emissions-Tomographie (3)
- Quantenpunkt (3)
- RapidEye (3)
- Ratte (3)
- Rechnungslegung (3)
- Rezeptor (3)
- Schmerz (3)
- Signaltransduktion (3)
- Stoffwechsel (3)
- Structural Biology (3)
- TRAIL (3)
- Thrombose (3)
- Trypanosoma brucei (3)
- Universität Würzburg (3)
- Zellzyklus (3)
- amyotrophic-lateral-sclerosis (3)
- analysis of variance (3)
- angiogenesis (3)
- ants (3)
- asthma (3)
- bacteria (3)
- biodiversity (3)
- blood (3)
- blood flow (3)
- burden (3)
- crystal structure (3)
- dSTORM (3)
- diet (3)
- diversity (3)
- dopamine (3)
- drosophila melanogaster (3)
- ecology (3)
- efficacy (3)
- electronic structure (3)
- epithelial cells (3)
- evidence-based medicine (3)
- evolution (3)
- fluorescence (3)
- food-cues (3)
- genome (3)
- growth (3)
- guidelines (3)
- hypertension (3)
- indication for surgery (3)
- kidneys (3)
- laparoscopic ventral hernia repair (3)
- metastasis (3)
- miRNA (3)
- neurons (3)
- neuropathic pain (3)
- obesity (3)
- perioperative management (3)
- platelet activation (3)
- platelet aggregation (3)
- positron emission tomography (3)
- protein domains (3)
- rat (3)
- reveals (3)
- stress (3)
- transcription factors (3)
- (Ga,Mn)As (2)
- 3D (2)
- ADHS (2)
- ARPES (2)
- Achtsamkeit (2)
- Achtsamkeitsbasiertes Training (2)
- Adenosin (2)
- Adenosinrezeptor (2)
- Agrobacterium tumefaciens (2)
- Akt (2)
- Angiotensin II (2)
- Angst (2)
- Antigen CD40 (2)
- Antigen CD8 (2)
- Apoptose (2)
- Aufmerksamkeit (2)
- Autonomous UAV (2)
- B-cells (2)
- Bayern (2)
- Bestäuber (2)
- Bevacizumab (2)
- Bilanzpolitik (2)
- Biomarker (2)
- Biomaterial (2)
- Blutstillung (2)
- Borylene (2)
- CD27 (2)
- CD40 (2)
- CD70 (2)
- Calciumphosphate (2)
- Cancer (2)
- Catecholmethyltransferase <Catechol-0-Methyltransferase> (2)
- China (2)
- Cholesterinstoffwechsel (2)
- Chromatin (2)
- Chronophin (2)
- Click-Chemie (2)
- Compressed Sensing (2)
- DAPI staining (2)
- DNS-Schädigung (2)
- Depression (2)
- Differenzierung (2)
- Diversity (2)
- Docking (2)
- Dopamin (2)
- Drosophila melanogaster (2)
- Duchenne-Syndrom (2)
- Dünne Schicht (2)
- ELISPOT (2)
- ERN (2)
- Einzelhandel (2)
- Elektronentransfer (2)
- Empirische Forschung (2)
- Engagement (2)
- Entwicklung (2)
- Europäische Union (2)
- Evolution (2)
- Excitons (2)
- Farbstoff (2)
- Femtosekundenspektroskopie (2)
- Fernerkundung (2)
- Fettgewebe (2)
- Fettsucht (2)
- Fluoreszenzmikroskopie (2)
- Fotovoltaik (2)
- Gammastrahlung (2)
- Gastric-banding (2)
- Gibbs free energy of binding (2)
- Glioblastoma (2)
- Gliom (2)
- Grammatik (2)
- HNSCC (2)
- Hearing loss (2)
- Herzinfarkt (2)
- Herzinsuffizienz (2)
- Herzmuskelzelle (2)
- Heterostruktur (2)
- Hfq (2)
- Hochauflösendes Verfahren (2)
- Hochauflösung (2)
- Hypertonie (2)
- Hämatopoese (2)
- Hämostase (2)
- Höranstrengung (2)
- Hörverlust (2)
- Immunologie (2)
- Insulin (2)
- Insulinresistenz (2)
- Interference microscopy (2)
- Japankärpfling (2)
- Kilimandscharo (2)
- Kilimanjaro (2)
- Klassifikation (2)
- Knochen-Morphogenese-Proteine (2)
- Kohlenhydrate (2)
- Kollagen (2)
- Krebs <Medizin> (2)
- LASP1 (2)
- LC-MS (2)
- Lagerungsplagiozephalus (2)
- Laparoskopie (2)
- MAP-Kinase (2)
- MRT (2)
- MS (2)
- Makrophage (2)
- Makrophagen (2)
- Manganarsenide (2)
- Maschinelles Lernen (2)
- Massenspektrometrie (2)
- Medizin (2)
- Meeresschwämme (2)
- Melanom (2)
- Merkel cell carcinoma (2)
- Mesenchymzelle (2)
- Mikroporosität (2)
- Mikroskopie (2)
- Multiple myeloma (2)
- Multiples Myelom (2)
- Museum (2)
- Myokardinfarkt (2)
- NET (2)
- Nachhaltigkeit (2)
- Nahfeldoptik (2)
- Nanodiamant (2)
- Nanoröhre (2)
- Nanostruktur (2)
- Neisseria gonorrhoeae (2)
- Neisseria meningitidis (2)
- Nernst-Effekt (2)
- Neurodegeneration (2)
- Onkologie (2)
- Onkolyse (2)
- Optische Spektroskopie (2)
- PALM (2)
- PET (2)
- PRRT (2)
- Parkinson's disease (2)
- Parkinsons disease (2)
- Pemphigus (2)
- Pharmakokinetik (2)
- Phosphatidylinositolkinase <Phosphatidylinositol-3-Kinase> (2)
- Photolumineszenz (2)
- Photostrom (2)
- Photovoltaik (2)
- Plasmozytom (2)
- Platelet (2)
- Platinkomplexe (2)
- Polymerkomplexe (2)
- Polymorphismus (2)
- Positron emission tomography (2)
- Prognose (2)
- Psychische Störung (2)
- Pyracen (2)
- RNA extraction (2)
- RNA-SEQ (2)
- RNS-Spleißen (2)
- Raman-Spektroskopie (2)
- Rashba effect (2)
- Regionalentwicklung (2)
- Renin-Angiotensin-Aldosteron-System (2)
- Rhabdomyosarcoma (2)
- Rituximab (2)
- Scanning microscopy (2)
- Seebeck-Effekt (2)
- Sensor (2)
- Serotonin (2)
- Silicium (2)
- Software Defined Networking (2)
- Sol-Gel-Verfahren (2)
- Splicing (2)
- Sprachentwicklung (2)
- Stammzelle (2)
- Staphylococcus aureus (2)
- State-of-the-Art (2)
- Sternpolymere (2)
- Structure-based drug design (2)
- Strukturbasiertes Wirkstoffdesign (2)
- Synapse (2)
- Systematischer Überblick (2)
- TRIB3 (2)
- TWEAK (2)
- TerraSAR-X (2)
- Therapie (2)
- Tiermodell (2)
- Transcription factor (2)
- Transforming Growth Factor (2)
- Ultrakurzzeitspektroskopie (2)
- West Africa (2)
- Westafrika (2)
- Wirtschaftsprüfung (2)
- Zivilgesellschaft (2)
- absolute configuration (2)
- accelerometer (2)
- actins (2)
- adults (2)
- aging (2)
- akutes Koronarsyndrom (2)
- antigenic variation (2)
- anxiety (2)
- aorta (2)
- apis mellifera (2)
- archaea (2)
- aspergillus fumigatus (2)
- atherosclerosis (2)
- autophagy (2)
- bees (2)
- binding (2)
- bioactivity (2)
- biological locomotion (2)
- biological sciences (2)
- biomarker (2)
- biomarkers (2)
- biosynthesis (2)
- bipolar disorder (2)
- blood-brain barrier (2)
- body weight (2)
- calcium imaging (2)
- carbohydrates (2)
- carcinomas (2)
- cell cultures (2)
- central nervous system (2)
- chemokines (2)
- chemotherapy (2)
- chronic kidney disease (2)
- clothing (2)
- communication (2)
- comparative genomics (2)
- complex (2)
- consciousness (2)
- crosstalk (2)
- culture (2)
- cytotoxic T cells (2)
- death rates (2)
- density functional theory (2)
- depression (2)
- dereplication (2)
- diagnosis (2)
- diagnostic medicine (2)
- dieting success (2)
- differentiation (2)
- down regulation (2)
- drug delivery (2)
- eating behavior (2)
- echocardiography (2)
- electrochemistry (2)
- energy metabolism (2)
- enzyme-linked immunoassays (2)
- epidemiology (2)
- epigenetics (2)
- event-related potentials (2)
- factor XII (2)
- factor-I (2)
- fish model (2)
- follicular lymphoma (2)
- follow-up (2)
- foraging (2)
- fungal structure (2)
- fungi (2)
- gait (2)
- games (2)
- gastric cancer (2)
- gene regulation (2)
- genes (2)
- glioma (2)
- glutathione (2)
- glycolysis (2)
- green fluorescent protein (2)
- gyroscope (2)
- heart (2)
- hospitalizations (2)
- human (2)
- humans (2)
- identification (2)
- immunohistochemistry techniques (2)
- inhibition (2)
- inhibitors (2)
- integrins (2)
- interference (2)
- leishmaniasis (2)
- lipid bilayer (2)
- lung and intrathoracic tumors (2)
- lymphocytes (2)
- macrophage (2)
- macrophages (2)
- man-computer interface (2)
- management (2)
- mass spectrometry (2)
- meiosis (2)
- melanoma (2)
- membrane (2)
- membrane proteins (2)
- messenger-RNA (2)
- midazolam (2)
- model (2)
- molecular beam epitaxy (2)
- multiple sclerosis (2)
- mutations (2)
- myocardial infarction (2)
- necrosis-factor-alpha (2)
- nervous system (2)
- neuroscience (2)
- nutrition (2)
- oncolytic viruses (2)
- opioids (2)
- organization (2)
- oscillation (2)
- outbreak (2)
- ovarian cancer (2)
- oxygen uptake (2)
- oxygenation (2)
- panic disorder (2)
- perception (2)
- photoelectron spectroscopy (2)
- photoluminescence (2)
- phylogenetic analysis (2)
- phylogenetic trees (2)
- plasmodium falciparum (2)
- pollination (2)
- polymerase chain reaction (2)
- polyneuropathy (2)
- poor prognosis (2)
- population (2)
- positron-emission-tomography (2)
- prediction (2)
- predictive value (2)
- prefrontal cortex (2)
- prognosis (2)
- progression (2)
- prostate cancer (2)
- protein aggregation (2)
- protein-protein interactions (2)
- proteins (2)
- pulmonary hypertension (2)
- pyracene (2)
- quality (2)
- recruitment (2)
- regulatory T cells (2)
- relapse (2)
- remote sensing (2)
- renal cancer (2)
- replication (2)
- resistance (2)
- responses (2)
- risk (2)
- risk factors (2)
- saccharomyces cerevisiae (2)
- scFv (2)
- scanning electron microscopy (2)
- scanning tunneling microscopy (2)
- secondary lung tumors (2)
- secretion (2)
- sepsis (2)
- sequence (2)
- sequence alignment (2)
- sex chromosomes (2)
- sleep (2)
- small interfering RNAs (2)
- solar cells (2)
- spin–orbit coupling (2)
- sponges (2)
- staphylococcus aureus (2)
- stem-cell transplantation (2)
- strains (2)
- stress resistance (2)
- stromal cells (2)
- super-resolution (2)
- superconductivity (2)
- surgical oncology (2)
- susceptibility (2)
- synaptic plasticity (2)
- target (2)
- telomeres (2)
- textile (2)
- time series (2)
- tissue saturation index (2)
- topological insulators (2)
- topologische Isolatoren (2)
- transcription (2)
- transcriptome (2)
- transcriptomics (2)
- transplantation (2)
- tumor (2)
- type 2 diabetes (2)
- tyrosine (2)
- ubiquitination (2)
- validation (2)
- venous system (2)
- video analysis (2)
- virtual reality (2)
- weight loss (2)
- young children (2)
- γδ T cells (2)
- "-omics" (1)
- (6,5)-SWNT (1)
- 11-beta-Hydroxylase (1)
- 17beta-Estradiol (1)
- 17beta-estradiol (1)
- 18-F-fluorothymidine uptake (1)
- 18FDG-PET/CT (1)
- 2 PM (1)
- 2-APB (1)
- 2-Methylallyl (1)
- 2-methylallyl (1)
- 3 Tesla (1)
- 3D Sensor (1)
- 3D Vision (1)
- 3D microscopy (1)
- 3D models (1)
- 3D-Pulverdruck (1)
- 3′ UTR (1)
- 5-Fluorouracil (1)
- 5-HT1A receptor (1)
- 5-bromodeoxyuridine (1)
- 5IA-SPECT (1)
- 60-nucleotide duplication (1)
- 6DOF Pose Estimation (1)
- 8-Oxo-2’-desoxyguanosin (1)
- 8-oxo-2'-deoxyguanosine (1)
- 9-Oxabispidin (1)
- 9-oxabispidine (1)
- A-D (1)
- AAER (1)
- AAPA (1)
- AAT (1)
- ABL gene (1)
- ABR Monitoring (1)
- ACH-2 (1)
- ACS (1)
- AG(110) (1)
- AL amyloidosis (1)
- AL-Amyloidose (1)
- ALCL (1)
- ALS (1)
- AMISOM (1)
- ANOVA (1)
- ANP (1)
- APCE (1)
- AQP (1)
- AQP4 (1)
- ARDS (1)
- ARF tumor-suppressor induced lymphomagenes (1)
- ARFIMA-Modell (1)
- ARFIMA-Modelle (1)
- ARMA-Modell (1)
- ART outcome (1)
- ASSET4 (1)
- ATG (1)
- ATG8 (1)
- ATLAS <Teilchendetektor> (1)
- ATM gene (1)
- ATP-binding cassette transporter (1)
- AVHRR (1)
- AVHRR data (1)
- Aberration (1)
- Abformmaterial (1)
- Abformung (1)
- Abschlussprüferhonorar (1)
- Absolute Configuration (1)
- Absolute Konfiguration (1)
- Absolutquantifizierung (1)
- Accelerometry (1)
- Ackerrandstreifen (1)
- Acromiopectorallappen (1)
- Actinoide (1)
- Actinokineospora (1)
- Action Research (1)
- Action feedback (1)
- Activin (1)
- Adaptation (1)
- Adapterprotein (1)
- Addiction (1)
- Adduct Complex (1)
- Addukt (1)
- Adduktbildung (1)
- Adenosine (1)
- Adenosine receptor (1)
- Adenylatcyclaseassay (1)
- Adipose Tissue (1)
- Adipositas (1)
- Adolescence (1)
- Adolf Hurwitz (1)
- Adsorptionsschicht (1)
- Adult (1)
- Adulte Stammzelle (1)
- African Trypanosomes (1)
- African Union (1)
- Afrika (1)
- Afrikanische Union (1)
- Aggregation (1)
- Agricultural land use (1)
- Aktien (1)
- Aktionsforschung (1)
- Aktive Zonen (1)
- Aktiver galaktischer Kern (1)
- Akustikusneurinom (1)
- Akute myeloische Leukämie (1)
- Akzeptorgruppe (1)
- Akzessibilität (1)
- Alanyl-Aminopeptidase (1)
- Aldosteron (1)
- Alexander von Wagner (1)
- Algebraic Curves (1)
- Algebraische Kurve (1)
- Alginat (1)
- Alginate (1)
- Alignment (1)
- Alignment <Biochemie> (1)
- Aliphaten (1)
- Alkalidotierte Calciumphosphatcemente (1)
- Alkaline phosphatase (1)
- Alkoholkonsum (1)
- Alkoholmissbrauch (1)
- Allergie (1)
- Alloantigenerkennung (1)
- Allophrynidae (1)
- Alpaca (1)
- Alternative Medizin (1)
- Alternative methods (1)
- Alternativmedizin (1)
- Alternativmethoden (1)
- Alterstraumatologie (1)
- Alterung (1)
- Alzheimer’s disease (1)
- Ameisen (1)
- Aminobisphosphonate (1)
- Aminoborylenkomplexe (1)
- Aminobuttersäure <gamma-> (1)
- Aminopenicilline (1)
- Amphiphile Verbindungen (1)
- Amu Darya (1)
- Amyloidose (1)
- Analgesia (1)
- Analgesie (1)
- Analysis of Variance (1)
- Anaphylaxis (1)
- Aneuploidy (1)
- Angiogenesis (1)
- Angle-Klasse III (1)
- Animal model (1)
- Anlegerschutz- und Funktionsverbesserungsgesetz (1)
- Anorganische Chemie (1)
- Anpassung (1)
- Anschleichen (1)
- Antenne (1)
- Anterior cruciate ligament (1)
- Anthracenderivate (1)
- Anthrachinonderivate (1)
- Antiangiogenese (1)
- Antibiotikum (1)
- Antibodies (1)
- Anticoagulants (1)
- Antiferromagnetismus (1)
- Antigen (1)
- Antigen CD4 (1)
- Antiinfektiva (1)
- Antimikrobieller Wirkstoff (1)
- Antimonverbindungen (1)
- Antipodes (1)
- Anura (1)
- Aortenklappenstenose (1)
- Approach-Avoidance-Task (1)
- Approximationsalgorithmus (1)
- Aquaporin 4 (1)
- Arabidopsis thaliana (1)
- Arbeitsablaufplanung (1)
- Arginine (1)
- Argonaute (1)
- Arten-Energy-Theory (1)
- Arterial Diameters (1)
- Arteriogenese (1)
- Arzneimitteldesign (1)
- Arzneimittelforschung (1)
- Aseptic loosening (1)
- Aspergillus fumigatus (1)
- Association (1)
- Assoziation (1)
- Astrocytic tumor (1)
- Astrozytom (1)
- Asymmetrie (1)
- Asymmetrische Synthese (1)
- Atemluftanalyse (1)
- Atemwege (1)
- Atherosclerosis (1)
- Atherosklerose (1)
- Atomic-force-microscopy (1)
- AtrbohD (1)
- Atriales natriuretisches Hormon (1)
- Atriales natriuretisches Peptid (1)
- Attention deficit / hyperactivity disorder (1)
- Attraktivität (1)
- Audiologie (1)
- Aufgabenwechsel (1)
- Aufmerksamkeitsdefizit-Syndrom (1)
- Aufmerksamkeitslenkung (1)
- Aufsatzsammlung (1)
- Aufsichtsrat (1)
- Auftauschicht (1)
- Aurora B (1)
- Auslandsgesellschaft (1)
- Autoaggressionskrankheit (1)
- Autoantikörper (1)
- Autoimmundermatose (1)
- Autoimmunerkrankung (1)
- Autoimmunität (1)
- Automatische Annäherungstendenzen (1)
- Autonomer Roboter (1)
- Autoreduzierbarkeit (1)
- Autotransporterprotein (1)
- Außenwirtschaftspolitik (1)
- Azine / Diazine (1)
- B cell receptors (1)
- B-Lymphozyt (1)
- B-Zell-Lymphom (1)
- BBL (1)
- BCL-X-L P53 (1)
- BCR-ABL (1)
- BDNF (1)
- BEGIN stimuli (1)
- BETA(2)-adrenergic receptor (1)
- BH3-only proteins (1)
- BK-Kanal (1)
- BMD (1)
- BMP (1)
- BTN3 (1)
- BTN3A1 and Phospho-antigen presentation (1)
- BYL-719 (1)
- Bach (1)
- Bacteria (1)
- Bakterien (1)
- Baltic Sea (1)
- Bambi (1)
- Bandscheibenerkrankung (1)
- Bandscheibenkrankheit (1)
- Bank (1)
- Barbed suture (1)
- Barbed suture material (1)
- Bariatric surgery (1)
- Bariatrische Chirurgie (1)
- Beckenbodensenkung (1)
- Becker-Kiener-Syndrom (1)
- Bedarfserhebung (1)
- Befragung von Menschen mit geistiger Behinderung (1)
- Bekleidungsvorschriften (1)
- Benzimidazoles (1)
- Berger-Parker (1)
- Bericht (1)
- Beschaffung (1)
- Beschallung (1)
- Bestimmung des Relaxations-Parameters in der Magnetresonanztomografie (1)
- Bestäubungsökologie (1)
- Beta-1-Rezeptor (1)
- Beteiligungspublizität (1)
- Beteiligungstransparenz (1)
- Bevölkerung / Sozialstruktur (1)
- Bewertung (1)
- Bharatiya Janata Party (1)
- Bias (1)
- Bibel. Judit (1)
- Bibliometrie (1)
- Bienen <Überfamilie> (1)
- Bildauflösung (1)
- Bilderkennnung (1)
- Bilderkennung (1)
- Bilderzeugung (1)
- Bildgebendes Verfahren (1)
- Bildgebung (1)
- Bildverarbeitung (1)
- Bilharziose (1)
- Bindungsaktivierung (1)
- Bindungsaktivierung <Chemische Bindung> <Aktivierung, Chemie> (1)
- Bindungsassay (1)
- Bingel-Hirsch-Reaktion (1)
- Bioanorganische Chemie (1)
- Bioengineering (1)
- Bioinformatics (1)
- Bioisosterie (1)
- Biologische Uhr (1)
- Biomedicine (1)
- Biomembran (1)
- Bioreactor System (1)
- Bioreaktor (1)
- Biosphärenreservat Sian Ka'an (1)
- Bipolar disorder (1)
- Bipolare Störung (1)
- Bismut (1)
- Bisphosphonates (1)
- Bispidin (1)
- Bispidinderivate (1)
- Blattflächenindex (1)
- Blattschneiderameisen (1)
- Blazar (1)
- Blei (1)
- Blut-Luft-Schranke (1)
- Board of directors (1)
- Bodennutzung (1)
- Bombus (1)
- Bombus Spp. Hymenoptera (1)
- Bone Morphogenetic Proteins (1)
- Bone regeneration (1)
- Bone tumor (1)
- Bor (1)
- Bordetella pertussis (1)
- Borheterocyclen (1)
- Borneo (1)
- Borole (1)
- Bortezomib (1)
- Boryl Anion (1)
- Borylentransfer (1)
- Bos taurus (1)
- Botanischer Garten (1)
- Brain (1)
- Brain-computer interface (1)
- Brassica napus (1)
- BrdU (1)
- Breast cancer cells (1)
- Bridging (1)
- Brustdrüse (1)
- Brustdrüsenentzündung (1)
- Brustkrebs (1)
- Brüder Hurwitz (1)
- Budgetrecht (1)
- Bumblebee (1)
- Burkholderia (1)
- Burkholderia pseudomallei (1)
- Burkitt Lymphom (1)
- Burkitt Lymphoma (1)
- Burma (1)
- Butterfly (1)
- Bürgerbeteiligung (1)
- C(-1019)G polymorphism (1)
- C-13-metabolic flux analysis (1)
- C-MYC (1)
- C-MYC PUMA (1)
- C-Terminus (1)
- C/EBPβ (1)
- C/Si-Austausch (1)
- C1-inhibitor (1)
- C57BL/6 mice (1)
- C6 (1)
- CASP (1)
- CASPASE-3 (1)
- CCD (1)
- CCDC79 (1)
- CCL2 (1)
- CCN1 (1)
- CD coreceptors (1)
- CD-Spektroskopie (1)
- CD/metabolism (1)
- CD150 (1)
- CD20 (1)
- CD39 (1)
- CD4(+) (1)
- CD4(+) T-cells (1)
- CD40 gerichteter bifunktioneller scFv-TRAIL Fusionsproteine (1)
- CD40 ligand (1)
- CD40-targeted bifunctional scFv-TRAIL fusion proteins (1)
- CD40L (1)
- CD46 (1)
- CD68 (1)
- CD73 (1)
- CD8(+) (1)
- CD8+ T cells (1)
- CD8+ T-Zellen (1)
- CK2 (1)
- CLAVATA3 (1)
- CLEC-2 ITAM (1)
- CML (1)
- CNS Myelination (1)
- CNVs (1)
- COMPLEX 1 (1)
- COMT (1)
- COMT polymorphism (1)
- COMT-Polymorphismus (1)
- CORMs (1)
- CPP-GMR (1)
- CRKL (1)
- CSVD (1)
- CT-gesteuerte Punktion (1)
- CTGF (1)
- CVD Synthese (1)
- CYP11A1 (1)
- CYP11B1 (1)
- CYP11B2 (1)
- CYP2W1 (1)
- CYR61 (1)
- Ca2+ release activated Ca2+ channel (1)
- Calciumhomöostase (1)
- Calciumkanal (1)
- Calciumtransport (1)
- Caloritronic (1)
- Cancer treatment (1)
- Candida albicans (1)
- Candidate Phylum Poribacteria (1)
- Cardiac hypertrophy (1)
- Cardiomyocytes (1)
- Carfilzomib (1)
- Caroticoclinoid-Foramen (1)
- Carotisdoppler (1)
- Carotisstenose (1)
- Carrier envelope phase effects (1)
- Cartesio (1)
- Cascades (1)
- Caspase 3/7 activity (1)
- Catechine (1)
- Catenine (1)
- Cav2.2 (1)
- Cell Cycle (1)
- Cell viability, (1)
- Cellular invasion (1)
- Central Asia (1)
- Central venous access (1)
- Centrolenidae (1)
- Cerebrospinal fluid (CSF) (1)
- Cestoda (1)
- Cestode (1)
- ChIP-Seq (1)
- Charcot-Marie-Tooth disease (1)
- Charge Carrier Generation (1)
- Charges recombination (1)
- Chemische Synthese (1)
- Chemokin CXCL10 (1)
- Chemotherapy (1)
- Chiralität <Chemie> (1)
- Chirurgie (1)
- Chlamydia (1)
- Chlamydia trachomatis (1)
- Chlamydia-trachomatis-Infektion (1)
- Chlorinderivate (1)
- Cholezystektomie (1)
- Chondrosarcoma (1)
- Chromosom 6 (1)
- Chromosomal Passenger Complex (1)
- Chromosome 6 (1)
- Chronic Mild Stres (1)
- Chronic disease (1)
- Chronic kidney disease (1)
- Chronische Herzinsuffizienz (1)
- Chronobiologie (1)
- Circadian Rhythms (1)
- Civil Society (1)
- Claudin-1 (1)
- Climate (1)
- Clinical psychotherapy (1)
- Cloud Gaming (1)
- Cluster <Wirtschaft> (1)
- Cluster-Offensive-Bayern (1)
- Clusterorganisation (1)
- Clusterplattform (1)
- Clusterpolitik (1)
- Co-Determination (1)
- Coagulation factor IX (1)
- Cochleaimplantat (1)
- Coexpression (1)
- Cognitive control (1)
- Collybistin (1)
- Colonkrebs (1)
- Columnare Phase (1)
- Combination therapy (1)
- Complex Continued Fractions (1)
- Computational physics (1)
- Computer Vision (1)
- Computerphysik (1)
- Computertomograph (1)
- Computertomographie (1)
- Conditioned inhibition (1)
- Conditioning (1)
- Conjugate function (1)
- Connective Tissue Growth Factor (1)
- Continental (1)
- Convoy Protection (1)
- Cooperative UAV (1)
- Copy number variation (1)
- Cord blood-derived hematopoietic stem and progenitor cells (1)
- Corporate Financial Performance (1)
- Corporate Governance (1)
- Corporate Sustainability (1)
- Correlates (1)
- Costa Rica (1)
- Coulomb-Blockade (1)
- Coumarin (1)
- Coupled-Cluster Theory (1)
- Coupled-Cluster-Theorie (1)
- Craving (1)
- Creatin Kinase (1)
- Crohns-disease (1)
- Cross-species analyses (1)
- Crosstalk (1)
- Crusaders (1)
- CsrA (1)
- CuAAC 'click' reaction (1)
- Cue (1)
- Cushing’s syndrome (1)
- Cutinase (1)
- Cyclo-AMP (1)
- Cyclophosphamide (1)
- Cytokine (1)
- Cytokines (1)
- Cytoskeleton Chromosomal Passenger Complex Interaction GAR Domain (1)
- D insufficiency (1)
- D serum-levels (1)
- DC optimization (1)
- DEL(5Q) (1)
- DETC (1)
- DHAP (1)
- DLBCL (1)
- DLX5/6 (1)
- DM-domain gene (1)
- DMD (1)
- DMS (1)
- DNA (1)
- DNA Repair (1)
- DNA base excision repair (1)
- DNA damage (1)
- DNA glycosation (1)
- DNA lesion (1)
- DNA methylation (1)
- DNA methyltransferase gene (1)
- DNA repair (1)
- DNA repair protraction (1)
- DNA-Basen (1)
- DNA-Methylierung (1)
- DNA-Reparatur (1)
- DNA-binding domain (1)
- DNA-binding proteins (1)
- DNA-damage checkpoint (1)
- DNMT3A (1)
- DNMT3B (1)
- DNS (1)
- DNS-Bindung (1)
- DNS-Reparatur (1)
- DNS-Schaden (1)
- DOPA-responsive-dystonia (1)
- DOT1 methyltransferase (1)
- DPR Deutsche Prüfstelle für Rechnungslegung (1)
- DRG (1)
- DRG-System (1)
- DSM-5 (1)
- DSM-IV (1)
- DVT (1)
- DWI (1)
- DYNC1I1 (1)
- Daniel <Buch 1 - 6> (1)
- Das Nibelungenbuch (1)
- Data Fusion (1)
- Data Quality (1)
- Datenqualität (1)
- Dauerfrostboden (1)
- Deceased Donor Score (1)
- Decentralized formation control (1)
- Deep sequencing (1)
- Demethylierung (1)
- Dendrimere (1)
- Dendrimers (1)
- Dendritische Zellen (1)
- Dengue (1)
- Dentalimplantat (1)
- Dentalwerkstoff (1)
- Dependenz (1)
- Der Granatapfelbaum (1)
- Deregulierung (1)
- Descensus (1)
- Descensus uteri (1)
- Descensus vaginalis (1)
- Descensuschirurgie (1)
- Desmoglein 2 (1)
- Desmoglein 3 (1)
- Desmogleine (1)
- Deutsch (1)
- Deviseninterventionen (1)
- Dexamethason (1)
- Dezentralisierung (1)
- Diabetes mellitus / Typ 2 (1)
- Diabetes mellitus / Typ II (1)
- Diboren (1)
- Dichtegradient (1)
- Dichtegradientenzentrifugation (1)
- Die Nibelungen (Film) (1)
- Died Blood Spot (1)
- Died Plasma Spots (1)
- Diels–Alder reaction (1)
- Differential GPS (DGPS) (1)
- Differentielle Genexpression (1)
- Differentielle Wirkungspfade (1)
- Digitale Volumentomographie (1)
- Digitalisierung (1)
- Dilatative Kardiomyopathie (1)
- Dimension 3 (1)
- Dimerisierung (1)
- Directed Flight (1)
- Disordered semiconductor (1)
- Dispergierung (1)
- Dissemination (1)
- Distributed Control (1)
- Domain-specific approach (1)
- Domäne <Biochemie> (1)
- Donor-Score (1)
- Donorgruppe (1)
- Dopamin-Transporter (1)
- Dopamine transporter (1)
- Dreidimensionales Bild (1)
- Dreiecksgitter (1)
- Driver Assistance Systems (1)
- Drosophila (1)
- Drought (1)
- Drug allergy (1)
- Drug reaction (1)
- Dual RNA-seq (1)
- Dual gap function (1)
- Dualitätstheorie (1)
- Durchflusscytometrie (1)
- Durchsetzung der Rechnungslegung (1)
- Dutch Disease (1)
- Dynamic stopping (1)
- Dynein Light Chain (1)
- Dyson orbitals (1)
- Dysplasie (1)
- E-Bonds (1)
- E-Learning (1)
- E. coli Nissle (1)
- E2F3 (1)
- EAAT2 (1)
- EAE (1)
- EBM (1)
- EGFR (1)
- EHEC (1)
- EKG (1)
- EL-4 Zellen (1)
- END stimuli (1)
- EPC (1)
- EPG (1)
- ERCC1-XPF (1)
- ERCC4 (1)
- ERK (1)
- ERK signaling cascade (1)
- ERM proteins (1)
- ERPs (1)
- ESG (environmental, social, governance) (1)
- ESM (1)
- Eap (1)
- Early Posterior Negativity (1)
- Early collision warning (1)
- Echinococcosis (1)
- Echinococcus multilocularis (1)
- Ectopic bone formation (1)
- Effekte der absoluten Phase (1)
- Effizienz (1)
- Ehrenamtliche Tätigkeit (1)
- Eigeninjektion / self injection (1)
- Einfluss (1)
- Einkauf (1)
- Einkaufszentrum (1)
- Einmodenlaser (1)
- Einzel-Molekül (1)
- Einzelhandelsstrukturen (1)
- Einzelmolekülmikroskopie (1)
- Einzelmolekülspektroskopie (1)
- Einzelphotonenemisson (1)
- Elastin (1)
- Elections in India (1)
- Electron Transfer (1)
- Electronic Circular Dichroism (1)
- Elektroakupunktur (1)
- Elektrochemie (1)
- Elektrodenanordnung (1)
- Elektroencephalographie (1)
- Elektron-Transfer (1)
- Elektronen Tunneln (1)
- Elektronenspin (1)
- Elektronensprayionisations-Massenspektrometrie (1)
- Elektronenstruktur (1)
- Elektronentransport (1)
- Elektronische Eigenschaft (1)
- Elektronische Nase (1)
- Elektronischer Circulardichroismus (1)
- Elektrophysiologie (1)
- Elektrospinning (1)
- Elternarbeit (1)
- Elternbildung (1)
- Elterntraining (1)
- Embodied Cleansing (1)
- Embodied Cognition (1)
- Embodiment (1)
- Embryonale Stammzelle (1)
- Embryonale Stammzellen (1)
- Emotionales Essverhalten (1)
- Emotionales Eßverhalten (1)
- Emotionsregulation (1)
- Emotionsverarbeitung (1)
- Empirical Analysis (1)
- Enantioselektivität (1)
- Encephalomyelitis (1)
- Endocytose (1)
- Endogenous opioids (1)
- Endothelzelle (1)
- Endpoint Mobility (1)
- Energie-Transfer (1)
- Energy Harvesting (1)
- Energy Transfer (1)
- Engadin (1)
- Enhancement (1)
- Enterale Ernährung (1)
- Entnahmemorbidität (1)
- Entwicklung im 2. und 3. Lebensjahr, Entwicklungsdokumentation, Pikler, Pikler-Konzept, Beobachtungsbogen (1)
- Environmental Performance (1)
- Enzyme-linked immunosorbent assay (1)
- EpCAM (1)
- Epigenetic (1)
- Erdrutsch (1)
- Ereigniskorrelierte Potentiale (1)
- Ereigniskorreliertes Potenzial (1)
- Erk (1)
- Ernährung (1)
- Erwachsener (1)
- Erwinia amylovora (1)
- Erziehung (1)
- Erziehungsstil (1)
- Escherichia coli infections (1)
- Escherichia coli-Hfq (1)
- Escherichia coli-derived recombinant human bone morphogenetic protein-2 (1)
- Estradiol (1)
- Ethnografie des Sprechens (1)
- Ethnografische Beschreibung der Mennoniten-Kolonie Fernheim in Paraguay (1)
- Ethnographie of the Mennonite colony Fernheim in Paraguay (1)
- Ethnography of communication (1)
- Etomidat (1)
- Euro-GmbH (1)
- Euroanleihe (1)
- Eurobonds (1)
- Europa-GmbH (1)
- Europarecht (1)
- Europe (1)
- European Private Company (1)
- Europäische Grundfreiheiten (1)
- Europäische Privatgesellschaft (1)
- Europäische Union / Außenpolitik (1)
- Evaluation (1)
- Event-related potentials (1)
- Excited states spectroscopy (1)
- Exekutive Funktionen (1)
- Exercise testing (1)
- Exon Array (1)
- Exotics (1)
- Experimental Autoimmune Encephalomyelitis (EAE) (1)
- Experimental Physics (1)
- Experimental physics (1)
- Experimentelle Autoimmune Enzephalomyelitis (EAE) (1)
- Explorative analyses (1)
- Expression (1)
- Extrakorporale Befruchtung (1)
- Extraocular eye muscles (1)
- Extraversion (1)
- Extrazelluläre Matrix (1)
- Extremwert (1)
- Eysenck (1)
- FACS (1)
- FADD (1)
- FANCP (1)
- FAP alpha (1)
- FBXO6 (1)
- FDG-PET (1)
- FDG-PET/CT (1)
- FISH (1)
- FLS2 receptor (1)
- FLT-PET (1)
- FMRI (1)
- FNIRS (1)
- FOSL1 (1)
- FOSMN (1)
- FREP (1)
- Fabrication (1)
- Fabry disease (1)
- Face-Konzept nach Goffman (1)
- Facial EMG (1)
- Fahrerassistenz (1)
- Fahrerassistenzsysteme (1)
- Fanconi Anemia (1)
- Fanconi-Anämie (1)
- Fas-Signalweg (1)
- Fbw7 (1)
- Fear conditioning (1)
- Feature-Selection (1)
- Feedback-Generierung (1)
- Fehlermonitoring (1)
- Fehlerverarbeitung (1)
- Feldstärke (1)
- Fermi-Flüssigkeit (1)
- Fermionensystem (1)
- Ferroelektrikum (1)
- Festkörperchemie (1)
- Festkörperoberfläche (1)
- Fettsäure (1)
- Fibrin (1)
- Fibroblasten-Aktivierungs-Protein Alpha (1)
- Fibromyalgia syndrome (1)
- Fibromyalgie (1)
- Fibrose (1)
- Filter (1)
- Finanzierung (1)
- Finanzkrise (1)
- Finite Elemente (1)
- Fisher-Score (1)
- Flexor tendon repair (1)
- Fluorescence Upconversion (1)
- Fluoreszenz (1)
- Fluoreszenz Aufkonversion (1)
- Fluoreszenzlöschung (1)
- Flüssigkristall (1)
- Foldamere (1)
- Foldamers (1)
- Food Carvings Questionnaire (1)
- Food Cravings Questionnaires (1)
- Food craving (1)
- Forest management (1)
- Foxp3+CD4+ regulatorische T-Zelle (1)
- Foxp3+CD4+ regulatory T cell (1)
- Fraktionale Integration (1)
- Frakturschrift (1)
- Franz von Kutschera (1)
- Freiburg Speech Test (1)
- Freiburger Einsilbertest (1)
- Freiburger Sprachtest (1)
- Freisetzungskinetik (1)
- Freizügigkeit (1)
- French-Canadian patients (1)
- Froschlurche (1)
- Fructose (1)
- Fruktose (1)
- Frustration (1)
- Frustrierter Magnetismus (1)
- Frühe Kollisionswarnungen (1)
- Fuchsbandwurm (1)
- Function (1)
- Function Fields (1)
- Functional analyses (1)
- Funktion (1)
- Funktionalisierung <Chemie> (1)
- Funktionelle Annotation (1)
- Funktionelle Kernspintomographie (1)
- Funktionenkörper (1)
- Fzd3 (1)
- G protein-coupled receptor (1)
- GAAS (1)
- GABA (1)
- GAS2L3 (1)
- GC-A (1)
- GC-MS (1)
- GCH1 (1)
- GFP (1)
- GH response (1)
- GIS-based Modelling (1)
- GLV-1 h153 (1)
- GPS Reciever (1)
- GTL2 (1)
- GUT (1)
- GVHD (1)
- GWAS (1)
- Galectine (1)
- Galliumarsenid-Bauelement (1)
- Galois theory (1)
- Galoistheorie (1)
- Gamet (1)
- Gamma-Burst (1)
- Gammaastronomie (1)
- Gastrulation (1)
- Gebirgspermafrost (1)
- Gebärmutterhalskrebs (1)
- Gecko (1)
- Geistigbehindertenpädagogik (1)
- Geldpolitik (1)
- Geleitzug (1)
- Gelfilm (1)
- Gemeinsame Afrika-EU-Strategie (1)
- Gen notch (1)
- Gen-Knockout (1)
- Gene regulation (1)
- Gene sets (1)
- Gene therapy (1)
- General Circulation Model (1)
- General amplifier model (1)
- Generalized Nash equilibrium (1)
- Generalized Probabilistic Theories (1)
- Generic questionnaire (1)
- Genetics (1)
- Genetik (1)
- Genotype-phenotype association (1)
- Genregulation (1)
- Gentoxizität (1)
- Genyue ji (1)
- Geoinformationssystem (1)
- Geophysics (1)
- Geophysikalische Methoden (1)
- Gephyrin (1)
- Gerinnungsfaktor XII (1)
- Germanium (1)
- Germinative cell (1)
- Geschichte (1)
- Geschichte 2014 (1)
- Geschlechtsbestimmung (1)
- Gesellschaftsrecht (1)
- Gesellschaftsstatut (1)
- Gesicht (1)
- Gesprächsanalyse (1)
- Gesundheitsgefährdung (1)
- Gesundheitsökonomie (1)
- Gewalt (1)
- Gewalttätigkeit (1)
- Gewebecharakterisierung (1)
- Gewebekultur (1)
- Gewährleistungsübernahme (1)
- Giantmagnetoresistance (1)
- Glacier forefield (1)
- Glatiramer acetate (1)
- Gletschervorfeld (1)
- GlideScope-Videolaryngoskop (1)
- GlideScope-videolaryngoscope (1)
- Glioblastom (1)
- Glioblastoma cell line (1)
- Glioblastoma multiforme (1)
- Glioma (1)
- Gliotoxin (1)
- Global Navigation Satellite System (GNSS) (1)
- Global Positioning System (GPS) (1)
- Glucocorticosteroide (1)
- Glucosetransporter (1)
- Glucosetransportproteine (1)
- Glutamat-Decarboxylase (1)
- Glutamatrezeptor (1)
- Glutathion (1)
- Glutathione (1)
- Glykane <N-> (1)
- Glykosylierung (1)
- Glykosyltransferase (1)
- Gonadenentwicklung (1)
- Graph (1)
- Graphenzeichnen (1)
- Grasses (1)
- Graves disease (1)
- Grenzüberschreitende Sitzverlegung (1)
- Grippe (1)
- Ground surface temperature (1)
- Group therapy (1)
- Grundfreiheit (1)
- Grundfrequenz (1)
- Grundfrequenzparameter (1)
- Grundlage (1)
- Grundlagen der Quantentheorie (1)
- Gruppentherapie (1)
- Guanylatzyklase (1)
- Guanylylcyclase (1)
- Guillain-Barre-Syndrome (1)
- H-Dimerbildung (1)
- HAD phosphatase (1)
- HCV genotype-2 (1)
- HER2 (1)
- HERV-K (1)
- HIP osteoarthritis (1)
- HIV-1 (1)
- HIV-1 protease (1)
- HIV-Infektion (1)
- HIV-associated neurocognitive disorder (HAND) (1)
- HIV-assoziierte neurokognitive Störung (HAND) (1)
- HPA Axis (1)
- HUWE1 (1)
- Halb-Heusler Legierung NiMnSb (1)
- Halbleiter (1)
- Halbleiterphysik (1)
- Half Heusler alloy NiMnSb (1)
- Haloacid dehalogenase (1)
- Halofuginon (1)
- Halothane (1)
- Handlungswirksamkeit (1)
- Haplotyp (1)
- Haplotypanalyse (1)
- Harmonic (1)
- Harnwegsinfektion (1)
- Harte Röntgenstrahlung (1)
- Hashimoto Thyreoiditis (1)
- Hashimoto-Thyreoiditis (1)
- Hauptgruppenelement (1)
- Haut (1)
- Haydn, Joseph (1)
- HbA1c (1)
- HeLa cells (1)
- Head (1)
- Health promotion (1)
- Health-determinants (1)
- Heathen world (1)
- Heavy Fermion Systems (1)
- Heidentum <Motiv> (1)
- Heidenwelt (1)
- Heilung (1)
- Heißhunger (1)
- Helferzelle (1)
- Helmtherapie (1)
- Hematopoietic stem cell ex-vivo expansion (1)
- Hemmung (1)
- Herbivory (1)
- Hernie (1)
- Herstellung (1)
- Herzchirurgie (1)
- Herzkatheter (1)
- Herzrhythmusstörungen (1)
- Herzruptur (1)
- Herzthoraxchirurgie (1)
- Hesse (1)
- Heteroaromaten (1)
- Heterocyclische Carbene <-N> (1)
- Heusler (1)
- Heuslersche Legierung (1)
- Hexagonaler Kristall (1)
- Hey Proteine (1)
- Hey proteins (1)
- HgTe (1)
- Hickman catheter (1)
- Hidden-Markov-Modell (1)
- Hidden-Order of URu2Si2 (1)
- High throughput screening (1)
- High-fat diet (1)
- Higher-coordinate Compounds (1)
- Hill's powers (1)
- Hirninfarkt (1)
- Hirnstammimplantat (1)
- Hirntumor (1)
- Hirschsprung disease (1)
- Histon-Demethylase UTX (1)
- Histon-Methyltransferase (1)
- Histone (1)
- Historische Geographie (1)
- Hitzeschock-Proteine (1)
- Hochdurchsatzsequenzierung (1)
- Hochenergieastronomie (1)
- Hochfeld (1)
- Hochmittelalter (1)
- Hochschulbildung (1)
- Hochschulschrift (1)
- Honeybee (1)
- Honigwabengitter (1)
- Host-parasite interaction (1)
- Host-pathogen interactions (1)
- Hsp70 (1)
- Huayanggong jishi (1)
- Hubbard model (1)
- Hubbard-Modell (1)
- Hubbard-model (1)
- Human (1)
- Human endogenous retrovirus (1)
- Hurwitz spaces (1)
- Hurwitz-Raum (1)
- Huwe1 (1)
- Hybridpolymer (1)
- Hydra <Polyp> (1)
- Hydrocortison (1)
- Hydroxylradikal (1)
- Hyperalgesie (1)
- Hypercortisolism (1)
- Hyperkalaemia (1)
- Hypertrophie (1)
- Hypertrophy (1)
- Hypervalentes Molekül (1)
- Hypopharyngeal glands (1)
- Hypophysen-Zwischenhirn-System (1)
- Hypothalamisch-hypophysäre Achse (1)
- Hämsotase (1)
- Höhengradient (1)
- Höherkoordinierte Verbdinungen (1)
- Hüft-TEP-Implantation (1)
- Hüftgelenksprothese (1)
- I-lactate (1)
- I-tasser (1)
- IABP (1)
- IC 310 (1)
- ICD (1)
- ICD-10 (1)
- ICF2 (1)
- ICL (1)
- ICSI (1)
- IGF-I (1)
- IGF1 (1)
- II citrullinemia (1)
- IL-1 α und β (1)
- IL28B polymorphisms (1)
- IMSI (1)
- ISS (1)
- ITAM (1)
- ITAM-signalling (1)
- ITS2 (1)
- IctP (1)
- Identität (1)
- Identitätswahrende Sitzverlegung von Gesellschaften (1)
- Ideology Erfahrung (1)
- Ighmbp2 (1)
- Il 4 (1)
- Ileuseinleitung (1)
- Image Processing (1)
- Imaging (1)
- Immunaktivierung (1)
- Immune activation (1)
- Immuninfiltration (1)
- Immunkardiomyopathie (1)
- Immunohistochemistry (1)
- Immunosuppression (1)
- Immunsystem (1)
- Immuntherapie (1)
- Impact-Faktor (1)
- Impedanzspektroskopie (1)
- Implantat (1)
- Implantatentwicklung (1)
- Implantatmatrices (1)
- Improved survival (1)
- In vitro (1)
- In vitro rat (1)
- In vivo Imaging (1)
- Incentive motivation (1)
- India (1)
- Indian National Congress (1)
- Indien (1)
- Indien <Parliament> (1)
- Induction of general anaesthesia (1)
- Infection imaging (1)
- Infektion (1)
- Infektionsbildgebung (1)
- Infektionsbiologie (1)
- Inflammatory pain (1)
- Inflation Targeting (1)
- Information Retrieval (1)
- Infrarotspektroskopie (1)
- Inhalation (1)
- Innenstadt (1)
- Innere Uhr (1)
- Insects (1)
- Instrumentalmusik (1)
- Insulin resistance (1)
- Intensivmedizin (1)
- Interferenzen (1)
- Interferon <Gamma-> (1)
- Interleukin-2 (1)
- Interleukin-5 (1)
- Internationales Gesellschaftsrecht (1)
- Intersektionalität (1)
- Intravital imaging (1)
- Introversion (1)
- Intubationszeit (1)
- Invasion (1)
- Inzidenz (1)
- Inzidenz <Medizin> (1)
- Iowa Gambling Task (1)
- Irak (1)
- Iran (1)
- Iraq (1)
- Irradiation (1)
- Ischämische Postkonditionierung (1)
- Isoform (1)
- Isomer (1)
- Jahresabschluss (1)
- Jahresbericht (1)
- Jordanien (1)
- Judit (1)
- Julius Hurwitz (1)
- KSR1 (1)
- Kaifeng (1)
- Kaiser Huizong (1)
- Kaiser test (1)
- Kalorimetrie (1)
- Kaloritronik (1)
- Kapitalmarktrecht (1)
- Kaposi sarcoma (1)
- Kardioprotektion (1)
- Kartellrecht (1)
- Kartellverbot (1)
- Kartierung (1)
- Kaskaden (1)
- Keck-Formel (1)
- Keck-Grundsätze (1)
- Keimbildung (1)
- Kenyon cells (1)
- Keratinozyt (1)
- Keratinozyten (1)
- Kernporen-Komplex (1)
- Ketonkörper (1)
- Kettenbruch (1)
- Kidney cancer (1)
- Kinase inhibitor (1)
- Kinasen (1)
- Kind (1)
- Kind <11-17 Jahre> (1)
- Kinder (1)
- Kinder im Vorschulbereich (1)
- Kinder- und Jugendpsychiatrie (1)
- Kindertagesstätte (1)
- Klassische Konditionierung (1)
- Kleidung (1)
- Klein- und Mittelbetrieb (1)
- Klima (1)
- Klimaschwankung (1)
- Klinik (1)
- Klinische Psychotherapie (1)
- Knochendichte (1)
- Knochenmark (1)
- Knochenmarktransplantation (1)
- Knock-Out (1)
- Knockout <Molekulargenetik> (1)
- Knockout mouse (1)
- Knockout-Maus (1)
- Knorpelzelle (1)
- Knotless tendon repair (1)
- Knowledge engineering (1)
- Kognitive Kontrolle (1)
- Kohlenmonoxid (1)
- Kohlenstoff-Kohlenstoff-Bindung (1)
- Kohlenstoff-Nanoröhre (1)
- Kohlenwasserstoffe (1)
- Kointegration (1)
- Kolonkarzinom (1)
- Komfortvokalisation (1)
- Kommunalverwaltung (1)
- Kommunikationsbeteiligung (1)
- Kommunikationssystem (1)
- Kommunikationsverhalten (1)
- Kompetenzbereich (1)
- Komplement (1)
- Komplexeinrichtung (1)
- Komplexitätsklasse (1)
- Komplexitätstheorie (1)
- Komplikation (1)
- Komplikationen dentaler Implantate (1)
- Komplimentärmedizin (1)
- Komprimierte Abtastung (1)
- Konditionierung (1)
- Kondo-Effekt (1)
- Kondo-Modell (1)
- Konflikt (1)
- Konfliktbewältigung (1)
- Konfokale Mikroskopie (1)
- Kongress (1)
- Konjugierte Polymere (1)
- Konrad <der Pfaffe> / Rolandslied (1)
- Konstruktive Didaktik (1)
- Kontingenz (1)
- Kontrastmittel (1)
- Kontrollierte klinische Studie (1)
- Konversationsanalyse (1)
- Konvoi (1)
- Konzerninsolvenzrecht (1)
- Koordinationspolymer (1)
- Koordinationspolymere (1)
- Kopf (1)
- Kopforthesentherapie (1)
- Koronarintervention (1)
- Koronarsyndrom (1)
- Korrelative Mikroskopie (1)
- Kortikale Regulation (1)
- Kosmische Strahlung (1)
- Kosten-Nutzen-Analyse (1)
- Koxarthrose (1)
- Kraniopharyngiom (1)
- Krebs (1)
- Krebserkrankung (1)
- Kreuzband (1)
- Kreuzung (1)
- Kreuzungsminimierung (1)
- Kreuzvalidierung (1)
- Krieg (1)
- Kristallfläche (1)
- Kristallisation (1)
- Kuh (1)
- Kunstgeschichte (1)
- Kurve (1)
- Kurzzeitphysik (1)
- Kutane Sarkome (1)
- Käfer (1)
- Körperstereotaktische Bestrahlung (1)
- L-3,4-Dihydroxyphenylalanine-induced dyskinesia (1)
- LAALO3/SRTIO3 interfaces (1)
- LARP4B (1)
- LAT2 (1)
- LC-MS/MS (1)
- LCK (1)
- LCST (1)
- LIN9 (1)
- LNCaP (1)
- LPS (1)
- LRP1 (1)
- LTT (1)
- Labial glands (1)
- Lactose (1)
- Ladungsträgergenerierung (1)
- Landkartenbeschriftung (1)
- Landnutzungsgradient (1)
- Landschaftsgarten (1)
- Landslide Susceptibility (1)
- Langlebigkeit (1)
- Langzeiteffektivität (1)
- Lanthanoide (1)
- Laparoskopische Cholecystektomie (1)
- Laplacian (1)
- Larvae (1)
- Larve (1)
- Laryngoskop (1)
- Laser Doppler vibrometer (1)
- Laserchemie (1)
- Laserspektroskopie (1)
- Late Positive Potential (1)
- Latrophilin receptor (1)
- Learning (1)
- Leaves (1)
- Lebenszyklus (1)
- Leber (1)
- Legionella pneumophila (1)
- Legumes (1)
- Lehrerhandreichung (1)
- Leishmania (1)
- Leishmaniose (1)
- Leitfähigkeit (1)
- Lenalidomid (1)
- Leptin (1)
- Leptoquark (1)
- Lernen (1)
- Lernort (1)
- Lernprogramm (1)
- Leseförderung (1)
- Lesetest (1)
- Leseverstehen (1)
- Leseverständnis (1)
- Leseverständnistest (1)
- Leuchtstoff (1)
- Leukapherese (1)
- Lichtstreuung (1)
- Lidocain (1)
- Ligand <Biochemie> (1)
- Liganden (1)
- Lineares System (1)
- Linguistische Methodik (1)
- Lipid-Carrier-Proteine (1)
- Lipidtransferprotein (1)
- Lippen (1)
- Liquor (1)
- Literatur (1)
- Literatur Review (1)
- Literature Review (1)
- Local Governance (1)
- Lok Sabha (1)
- Lokalisationsmikroskopie (1)
- Long-Memory-Prozesse (1)
- Long-term efficiency (1)
- Longitudinal analysis (1)
- Low-fat diet (1)
- Lumineszenz (1)
- Lung cancer (1)
- Lungenalveole (1)
- Lungenkrebs (1)
- Lymphozyten (1)
- Lymphozyten mediierter Angriff auf Neurone (1)
- Lymphozytentransformationstest (1)
- Lysine (1)
- Lysosomal storage disease (1)
- MAG3 (1)
- MAGIC-Teleskop (1)
- MALDI-MS (1)
- MAP Kinase Signaling (1)
- MAPK (1)
- MAPK signaling cascades (1)
- MCL-1 (1)
- MDS (1)
- MFM (1)
- MHC molecules (1)
- MIR-155 (1)
- MIZ1 (1)
- MMN (1)
- MODIS (1)
- MOF (1)
- MOPC315.BM (1)
- MRI criteria (1)
- MSOT (1)
- MVT (1)
- MYC (1)
- Macintosh-Laryngoskop (1)
- Macintosh-laryngoscope (1)
- Macrophage (1)
- Magenbypass (1)
- Magenchirurgie (1)
- Magnesiumphosphate (1)
- Magnesiumphosphatschäume (1)
- Magnetic Resonance Relaxometry (1)
- Magnetische Anisotropie (1)
- Magnetresonanz-Relaxometrie (1)
- Magnetresonanztomographie (1)
- Maiglöckchen (1)
- Maintenance treatment (1)
- Malabsorption (1)
- Malaria (1)
- Malaria tropica (1)
- Malassimilation (1)
- Malignant hyperthermia (1)
- Maligne Tumoren (1)
- Managed Floating (1)
- Mangankomplexe (1)
- Manganverbindungen (1)
- Mangelernährung (1)
- Mania (1)
- Marine sponge (1)
- Marktbürger (1)
- Markterwartungshypothese (1)
- Marokko (1)
- Maschinelles Sehen (1)
- Masern (1)
- Masernvirus (1)
- Mass spectrometry (1)
- Massenbewegung <Geomorphologie> (1)
- Massentrachten (1)
- Mastocytosis (1)
- Materielle Kultur (1)
- Mathematisches Modell (1)
- Matlab (1)
- Mausmodell (1)
- Mbm (1)
- MeDALL (1)
- Measurement invariance (1)
- Medienpädagogik (1)
- Mediterranean (1)
- Medizintechnik (1)
- Mehrkriterielle Optimierung (1)
- Meiose (1)
- Melanin (1)
- Melanoma (1)
- Melanomzelllinien (1)
- Meldepflichten (1)
- Melphalan (1)
- Membrandomänen (1)
- Meniskustransplantation (1)
- Mennonitendeutsch (1)
- Mensch (1)
- Merocyanine (1)
- Merocyaninfarbstoffe (1)
- Mesenchymal stem cells (1)
- Mesenchymale Stammzelle (1)
- Mesh (1)
- Mesocestoides vogae (1)
- Mesoporous (1)
- Messenger-RNS (1)
- Meta-Analyse (1)
- Metabolic Modelling (1)
- Metabolischen Modellierung (1)
- Metabolismus (1)
- Metal-only Lewis-Pairs (1)
- Metall-zentrierte Lewis-Paare (1)
- Metalloproteinasen (1)
- Metallorganische Verbindungen (1)
- Metallorganisches Netzwerk (1)
- Metastases (1)
- Metatranscriptomics (1)
- Methylene blue (1)
- Methylphenidat (1)
- Metomidat (1)
- Mevalonatmetabolimus (1)
- Mexican coffee plantations (1)
- Mexico (1)
- Mexiko (1)
- MicroRNA (1)
- Microarray (1)
- Microbial community (1)
- Microcavity devices (1)
- Migration (1)
- Mikrofertigung (1)
- Mikroresonator (1)
- Mikrosatellit (1)
- Mikrosatelliteninstabilität (1)
- Milchdrüse (1)
- Milz (1)
- Mineralokortikoidrezeptor (1)
- Mini Unmanned Aerial Vehicle (1)
- Minimal-invasive Chirurgie (1)
- Minipools (1)
- Mitbestimmung (1)
- Mitose (1)
- Mitotizität (1)
- Mittelhochdeutsch (1)
- Mittelmeerraum (1)
- Mittelstand (1)
- Miz1 (1)
- Mobile Sensor Network (1)
- Mobiles Internet (1)
- Model Based Reconstruction Algorithms in Magnetic Resonance Imaging (1)
- Modell (1)
- Modellbasierte-Rekonstruktionsalgorithmen in der Magnetresonanztomografie (1)
- Modellierung (1)
- Modifizierung (1)
- Molecular imaging (1)
- Molecular motion (1)
- Molekularbewegung (1)
- Molekulardesign (1)
- Molekulare Bildgebung (1)
- Molekulare Erkennung (1)
- Molekulargenetik (1)
- Molekularstrahl Epitaxie (1)
- Molekularstrahlepitaxie (1)
- Molekülphysik (1)
- Monadische Komposition (1)
- Monetit (1)
- Monitorüberwachung (1)
- Monoclonal Antibodies (1)
- Monodromie (1)
- Monodromy (1)
- Monopolar depression (1)
- Monoschicht (1)
- Monozyten (1)
- Monte-Carlo-Simulation (1)
- Morbus Alzheimer (1)
- Morbus Fabry (1)
- Morocco (1)
- Morphologie (1)
- Morris Water Maze (1)
- Motivation (1)
- Mountain permafrost (1)
- Mozart, Wolfgang Amadeus (1)
- Mucin (1)
- Mucorales (1)
- Multidimensionale Spektroskopie (1)
- Multidrug-Resistenz (1)
- Multiple Myeloma (1)
- Multiple Sclerosis (1)
- Multiple Sklerose (1)
- Multiport (1)
- Multivariate Zeitreihenmodelle (1)
- Multiwellenlängen (1)
- Murine models of thrombosis and haemostasis (1)
- Museumpädagogik (1)
- Mushroom bodies (1)
- Muskeldystrophie (1)
- Mustererkennung (1)
- Mutagenese (1)
- Mutationsraten (1)
- Mutter-Kind-Maßnahme (1)
- Mutterkindkur (1)
- Mutterkindvorsorge (1)
- Muttermilch (1)
- Myanmar (1)
- Myokardiales Remodeling (1)
- Myokardprotektion (1)
- N-Carboxyanhydride (1)
- N-Glykane (1)
- N-Myc (1)
- N-acetyllactosamine (1)
- N400 (1)
- NADPH-Oxidase (1)
- NCI H441 Zellen (1)
- NCI-H295 Zellen (1)
- NEIL2 (1)
- NF-kB (1)
- NFAT (1)
- NFATc1 (1)
- NFκB (1)
- NHC (1)
- NIRS (1)
- NK cells (1)
- NMO (1)
- NMR (1)
- NMR fingerprint (1)
- NMR-Tomographie (1)
- NRPS (1)
- NSAIDs (1)
- NTCDA (1)
- NVP-BEZ235 (1)
- NVP-BGT226 (1)
- Nah-Infrarot Reflexionsspektroskopie (1)
- Nahfeld Optik (1)
- Nahinfrarot-Spektroskopie (1)
- Nahrung (1)
- Nanoantenne (1)
- Nanodiamond (1)
- Nanog protein (1)
- Nanoimprint (1)
- Nanooptics (1)
- Nanooptik (1)
- Nanopartikel (1)
- Nanoporöser Stoff (1)
- Nanoprägen (1)
- Nanos (1)
- Nanostructures (1)
- Narkoseeinleitung (1)
- Narkosetechnik (1)
- Nase (1)
- Nash-Gleichgewicht (1)
- Natural Hazards (1)
- Neanderthal (1)
- Nebenniereninsuffizienz / adrenal insufficiency (1)
- Nebennierenkarzinom (1)
- Nebennierenkrise / adrenal crisis (1)
- Nebennierenrinde (1)
- Nebennierenrindeninsuffizienz (1)
- Nebennierenrindenkarzinom (1)
- Nebennierenrindenkrebs (1)
- Nectin4 (1)
- Nekrose (1)
- Neoblast (1)
- Nernst effect (1)
- Nervendegeneration (1)
- Nervensonographie (1)
- Nervenzelle (1)
- Nestbau (1)
- Netzwerkmanagement (1)
- Neues Steuerungsmodell (1)
- Neuroblast (1)
- Neuroblastom (1)
- Neuroligin 2 (1)
- Neurologische Komplikationen (1)
- Neuromyelitis optica (1)
- Neuronal ceroid lipofuscinosis (1)
- Neuronale Leitung (1)
- Neuronale Plastizität (1)
- Neuropeptide (1)
- Neuropeptide Hormone (1)
- Neuropeptidhormon (1)
- Neuroplasticity (1)
- Neurotizismus (1)
- Neurowissenschaften (1)
- Neutrino (1)
- Neutrino mass mixing (1)
- New Zealand (1)
- Newman strain sae (1)
- Nfatc1 (1)
- Nibelungenlied (1)
- Nicht-lokale Korrelationen (1)
- Nichtglatte Optimierung (1)
- Nichtionisierende Strahlung (1)
- Nichtlineare Spektroskopie (1)
- Nickelverbindungen (1)
- Nicotine (1)
- Nie Chongyi 聶崇義 (1)
- Niederlassungsfreiheit (1)
- Nierenfunktion (1)
- Niereninsuffizienz (1)
- Nierentransplantation (1)
- Nigeria (1)
- Nikaido-Isoda function (1)
- No-Bail-Out (1)
- Nogo-A (1)
- Non-invasive imaging (1)
- Non-steroidal anti-inflammatory drug (1)
- Nonlocal Correlations (1)
- North American (1)
- Northeastern Costa Rica (1)
- Northern Xinjiang (1)
- Notch Signalweg (1)
- Notch signalling (1)
- Notenbank (1)
- Novel PI3K (1)
- Novobiocin (1)
- Nuclear imaging (1)
- Nucleinbasen (1)
- Nukleosynthese (1)
- Numerische Physik (1)
- OCD (1)
- OCR (1)
- OCT (1)
- ODMR-Spektroskopie (1)
- OGG1 (1)
- Oberflächenfunktionalisierung (1)
- Oberflächenplasmonresonanz (1)
- Oberwelle (1)
- Obesity (1)
- Oct4 (1)
- Offenlegungspflichten (1)
- Okklusionsstörung (1)
- Omarthrose (1)
- Oncogene (1)
- Oncolytic Virotherapy (1)
- Onkogen (1)
- Onset (1)
- Oocytes (1)
- Oogenese (1)
- Oozyte (1)
- Oozyten (1)
- Opioid receptor (1)
- Opioidpeptide (1)
- Optical coherence tomography (1)
- Optimal control (1)
- Optimale Regelung (1)
- Optimalwertregelung (1)
- Optimierung (1)
- Optimization (1)
- Optische Fernerkundung (1)
- Optische Zeichenerkennung (1)
- Optischer Resonator (1)
- Orai1 (1)
- Organic Photovoltaics (1)
- Organic Semiconductors (1)
- Organic semiconductors (1)
- Organische Chemie (1)
- Organische Photovoltaik (1)
- Organische Synthese (1)
- Organisches Molekül (1)
- Organometallverbindungen (1)
- Osmoregulation (1)
- Osseointegartion (1)
- Osseointegration (1)
- Osteoporose (1)
- Out-of-school learning settings (1)
- Outcomes (1)
- Ovarialkarzinom (1)
- Oxidativer Stress (1)
- OxyR (1)
- Oxygen uptake (1)
- P-cresyl sulfate (1)
- P-gp inhibitors (1)
- P300 (1)
- P450scc (1)
- P50 (1)
- PARK2 (1)
- PCR analysis (1)
- PD-L1 (1)
- PDXP (1)
- PEG (1)
- PEG chemical modification (1)
- PEG-Anlage (1)
- PET/CT (1)
- PI3K (1)
- PI3K-Signalweg (1)
- PKS I (1)
- PKS II (1)
- PLP phosphatase (1)
- PMD (1)
- POLSCORE (1)
- PPD (1)
- PRC2 (1)
- PROLIFT (1)
- PSA (1)
- PSI-blast (1)
- PTCDA (1)
- PTCL (1)
- PZT (1)
- Palliativmedizin (1)
- Palliativmedizinische Tagesklinik (1)
- Palmitinsäure (1)
- Pamir (1)
- Pandemische Influenza A (1)
- Paraguay (1)
- Parallel Imaging (1)
- Parallele Bildgebung (1)
- Parametric optimization (1)
- Parametrische Optimierung (1)
- Parent-of-origin (1)
- Parkinson disease (1)
- Parlamentswahl (1)
- Particle Physics (1)
- Particle analytics (1)
- Partikelanalytik (1)
- Partizipatorische Demokratie (1)
- Partzipation (1)
- Passiv-Transfer (1)
- Pastorale (1)
- Patellarsehne (1)
- Patientenselektion (1)
- Pattern Mining (1)
- Pattern Recognition (1)
- Patulin (1)
- Pe (1)
- Pectoralis-Major-Lappen (1)
- Pediatric malignancy (1)
- Pentaerythrityltetranitrat (1)
- Pentakoordination (1)
- Peptide (1)
- Peptidtherapie (1)
- Peptoide (1)
- Performance Evaluation (1)
- Performance Management (1)
- Perfusion (1)
- Perinatal Asphyxia (1)
- Perineurium (1)
- Period2 (1)
- Periphere Analgesie (1)
- Persien (1)
- Persönlichkeit (1)
- Perylen (1)
- Perylenbisimid (1)
- Peyer's patches (1)
- Pharmakodynamik (1)
- Pharmakogenetik (1)
- Pharmakokinetik / pharmacokinetics (1)
- Pharynx (1)
- Phasenumwandlung (1)
- Phosphatasen (1)
- Phospho-Akt (1)
- Phospholamban (1)
- Phospholipase D (1)
- Phosphoproteine (1)
- Phosphorylierung (1)
- PhotoCORMs (1)
- Photoelektronenspektroskopie (1)
- Photoinduzierter Elektronentransfer (1)
- Photoionisation (1)
- Photonik (1)
- Photonische Kristalle (1)
- Photostrukturierung (1)
- Physical activity (1)
- Physik (1)
- Phytoplankton (1)
- Phänotyp (1)
- Pilocytic astrocytoma (1)
- Pilomyxoid astrocytoma (1)
- Pilomyxoides Astrozytom (1)
- Pilozytisches Astrozytom (1)
- Pioglitazon (1)
- Plagiocephalus (1)
- Plant-herbivore interactions (1)
- Plasmamembran (1)
- Plasmodium falciparum (1)
- Plasmon (1)
- Plasmon propagation (1)
- Plasmonics (1)
- Plastic electronics (1)
- Platelet count (1)
- Platinaddukte (1)
- Platinkomplex (1)
- Pneumothorax (1)
- PolSAR (1)
- Polarisierbarkeit (1)
- Polarity index (1)
- Politikwissenschaft (1)
- Pollination (1)
- Polylactide-co-glycolide (1)
- Polymer (1)
- Polymerase Kettenreaktion (1)
- Polymerase-Kettenrektion (1)
- Polymerisation (1)
- Polymers (1)
- Polymorphismen MMP-3 (1)
- Polypeptoid (1)
- Polypropylen-Netz (1)
- Polytrauma (1)
- Pomalidomid (1)
- Pooling (1)
- Popdc (1)
- Porsche (1)
- Port (1)
- Positioning (1)
- Posttranskriptionelle Regulation (1)
- Posttranslational modification (1)
- Posttranslationale Änderung (1)
- Potentialinduzierte Löschung (1)
- Predominant polarity (1)
- Probenecid (1)
- Probiotikum (1)
- Procurement (1)
- Profil (1)
- Profilierung (1)
- Profiling (1)
- Prognosis (1)
- Programmheft (1)
- Progressive Muskelentspannung (1)
- Progressive Relaxation (1)
- Prolaps (1)
- Proliferation (1)
- Proteaseinhibitor (1)
- Protected areas (1)
- Protein TRPC6 (1)
- Protein p53 (1)
- Protein-Protein-Wechselwirkung (1)
- Protein-Tyrosin-Kinasen (1)
- Proteindomänen (1)
- Proteindynamiken (1)
- Proteine (1)
- Proteintyrosinphosphatase (1)
- Proteomics (1)
- Proximaler Humerus (1)
- Präamplifizierung (1)
- Prädiktor (1)
- Prädiktoren (1)
- Präfrontaler Cortex (1)
- Präpositionen (1)
- Pseudo-allergy (1)
- Psoriasis (1)
- Psychologie (1)
- Psychopharmakologie (1)
- Psychophysiologie (1)
- Psychotherapie (1)
- Pulse shaping (1)
- Pulswellengeschwindigkeit (1)
- Pump-Probe-Spektroskopie (1)
- Punktion (1)
- Purcell-Effekt (1)
- Purchasing (1)
- PyMOL (1)
- Pyracylen (1)
- Pyridoxal 5'-phosphate phosphatase (1)
- Pyridoxalphosphat (1)
- Pyrrolidin (1)
- Pyrrolidinderivate (1)
- Q-CT (1)
- QKD (1)
- Quadrocopter (1)
- Quadrotor (1)
- Quality of Experience (1)
- Quality of life (1)
- Quality-of-Service (1)
- Qualität (1)
- Quantendynamik (1)
- Quantenkaskadenlaser (1)
- Quantenkommunikation (1)
- Quantenkontrolle (1)
- Quantentheorie (1)
- Quantifizierung (1)
- Quantum Foundations (1)
- Quantum dynamics (1)
- Quantum-well, -wire and -dot devices (1)
- Quasi-variational inequalities (1)
- Quecksilbertellurid (1)
- Querschnittsklausel (1)
- Questionnaire (1)
- Quetiapine (1)
- RAF1 (1)
- RAS (1)
- RCC (1)
- RDoC (1)
- RFID (1)
- RFP (1)
- RHO (1)
- RHO-associated kinease (1)
- RIM (1)
- RINEX Format (1)
- RNA (1)
- RNA CHAPERONE HFQ (1)
- RNA degradation (1)
- RNA sequence (1)
- RNA splicing (1)
- RNA-SEQ data (1)
- RNA-polymerase-I (1)
- RNA-polymerase-II (1)
- RNA-seq (1)
- RNAseq (1)
- RNS (1)
- RNS-Interferenz (1)
- ROK-alpha (1)
- ROS (1)
- RTMS (1)
- Rachitis (1)
- Radarsat-2 (1)
- Radioastronomie (1)
- Radiogalaxie (1)
- Radiologische Diagnostik (1)
- Radium (1)
- Raman spectroscopy (1)
- Rapid sequence induction (1)
- Raps (1)
- Rashba-Effekt (1)
- Rasterionenmikroskop (1)
- Rasterkraft-Mikroskopie (1)
- Rastertunnelmikroskop (1)
- Rauchen (1)
- Raumfahrt (1)
- Raumforderung (1)
- Reaktion (1)
- Reaktionskinetik (1)
- Reaktive Sauerstoffspezies (1)
- Reaktivität (1)
- Real-time PCR (1)
- Receptor kinase (1)
- Rechnernetz (1)
- Rechnungswesen (1)
- Recht (1)
- Rechtsprechung (1)
- Recombinant protein (1)
- Rectal cancer (1)
- Red Sea (1)
- Red sea (1)
- Redox-Stoffwechsel (1)
- Redoxpotential (1)
- Regional development (1)
- Regionale Wirtschaftsentwicklung (1)
- Regularisierung (1)
- Regularized gap function (1)
- Regulatorischer T-Lymphozyt (1)
- Regulatory Volume Decrease (1)
- Rehabilitation (1)
- Reifung (1)
- Reinfried von Braunschweig (1)
- Reizmuster (1)
- Rekombination (1)
- Rekonstruktion (1)
- Relaxation Parameter Mapping in Magnetic Resonance Imaging (1)
- Relaxationszeit (1)
- Remote sensing (1)
- Renal cell carcinoma (1)
- Renewable energies (1)
- Renin Angiotensin System (1)
- Renin-Angiotensin-System (1)
- Reperfusion (1)
- Reperfusions-induzierter Schaden (1)
- Repression <Genetik> (1)
- Reprogramming (1)
- Rescorla-Wagner model (1)
- Resensibilisierung (1)
- Resonatoren (1)
- Resonators (1)
- Resource and Performance Management (1)
- Ressourcenmanagement (1)
- Retail (1)
- Retest-reliability (1)
- Retinal degeneration (1)
- Reversal (1)
- Reward (1)
- Rezeption (1)
- Rhodobacter sphaeroides (1)
- Ribosom (1)
- Richardson-Olszewski-Syndrome (1)
- Riechstoff (1)
- Riesenmagnetowiderstand (1)
- Rind (1)
- Ringöffnungspolymerisation (1)
- Risikobegrenzungsgesetz (1)
- Risikoberatung (1)
- Risikofaktor (1)
- Risikofaktoren (1)
- Risikoverhalten (1)
- Riskanter Alkoholkonsum (1)
- Ritenklassiker (1)
- Ritus (1)
- Rituximab plus (1)
- Riutximab (1)
- Robotik (1)
- Rodung (1)
- Rotes Meer (1)
- Routing (1)
- Rupturen (1)
- Russian-German (1)
- Russisch-Deutsch (1)
- Russland (1)
- Rutschung (1)
- RyR1 mutations (1)
- Röntgen-Photoelektronenspektroskopie (1)
- Röntgenastronomie (1)
- Röntgenkristallographie (1)
- Röntgenmikroskop (1)
- Röntgenmikroskopie (1)
- Röntgenstrahlung (1)
- Rückmeldung (1)
- SAR (1)
- SERCA2a (1)
- SF-36 (1)
- SFE (1)
- SGLT-1 (1)
- SGLT2 inhibitor (1)
- SGN-35 (1)
- SGNH hydrolase (1)
- SH-6 (1)
- SH3-Domäne (1)
- SHFM (1)
- SHRSP (1)
- SLAM CDW150 (1)
- SLFN5 (1)
- SLX4 (1)
- SM-like protein (1)
- SMAD signaling (1)
- SMARD1 (1)
- SMN complex (1)
- SMN-Komplex (1)
- SNAP-Rezeptor (1)
- SNP array (1)
- SOCE (1)
- SPE (1)
- SPION (1)
- SPR-Spektroskopie (1)
- SPRED2 (1)
- SR proteins (1)
- SREBP (1)
- SREBP-2 (1)
- SREC-I (1)
- SRTIO3 (1)
- STAT3 (1)
- SUN1 (1)
- SWI2/SNF2-like protein (1)
- Salmonella enterica (1)
- Salmonella-containing vacuole (SCV) (1)
- Salzstress (1)
- Sanli tu 三禮圖 (1)
- Saproxylic beetles (1)
- Saproxylophage (1)
- Sarkom (1)
- ScFv (1)
- Scaffold fabrication (1)
- Scattering (1)
- Schaeffler (1)
- Schermischen (1)
- Schielen (1)
- Schieloperation (1)
- Schilddrüse (1)
- Schilddrüsenhormonmetabolismus (1)
- Schizophrenia (1)
- Schizophrenie (1)
- Schlaf (1)
- Schlafstörung (1)
- Schlaganfall (1)
- Schneeschmelze (1)
- Schold-Score (1)
- Scholl reaction (1)
- Scholl-Reaktion (1)
- Schreckreaktion (1)
- Schrei (1)
- Schulbuchforschung (1)
- Schuldenkrise (1)
- Schule (1)
- Schuppenflechte (1)
- Schutzgebiete (1)
- Schwangerschaft (1)
- Schwebfliegen (1)
- Schweineinfluenza (1)
- Schwere-Fermionen-System (1)
- Schwerverletzte (1)
- Schwerverletztenversorgung (1)
- Schwingungsspektroskopie (1)
- Schönheit (1)
- Scoring functions (1)
- Scoring-Funktionen (1)
- Scoringfunktionen (1)
- Sechsecknetz (1)
- Sedentary behaviour (1)
- Sedimentation (1)
- Seebeck effect (1)
- Sekundarstufe (1)
- Selbstorganisation (1)
- Selbstregulation (1)
- Selection of patients (1)
- Sella turcica (1)
- Semi- und nichtparametrische Methoden (1)
- Semiconductors physics (1)
- Semitendinosussehne (1)
- Sensory Gating (1)
- Septuaginta (1)
- Sequence motif analysis (1)
- Serotonin Transporter (1)
- Service Mobility (1)
- Set-valued mapping (1)
- Sex (1)
- Sex determination (1)
- Sexual development (1)
- Shift (1)
- Shiga toxin-producing Escherichia coli (1)
- Shopping-Center (1)
- Short-term-Variabilität (1)
- Sicherheitspolitik (1)
- Siciliano (1)
- Signal Noise (1)
- Signalpeptide (1)
- Signalwege (1)
- Sila-Substitution (1)
- Silber (1)
- Silicate (1)
- Silicium(II)-Komplexe (1)
- Silicium(IV)-Komplexe (1)
- Siliciumcarbid (1)
- Siliciumkomplexe (1)
- Siliciumorganische Verbindungen (1)
- Silicon(II) Complexes (1)
- Silicon(IV) Complexes (1)
- Silikon (1)
- Siloxane (1)
- Silylen (1)
- Simulation (1)
- Simulationstraining (1)
- Single Port Cholezystektomie (1)
- Single chain (1)
- Single-Port (1)
- Single-molecule (1)
- Singlet Fission (1)
- Sitting/standing (1)
- Sitzverlegung (1)
- Sjorgens-syndrome (1)
- Skin biopsy (1)
- Skint1 (1)
- Sleep disorders (1)
- Small nuclear RNP (1)
- Small-angle X-ray Scattering (1)
- Smoking (1)
- SnRK1 (1)
- Snap25 (1)
- Social Cognition (1)
- Societas Privata Europaea (1)
- Société fermée européenne (1)
- Software Engineering (1)
- Software Performance Engineering (1)
- Software Performance Modeling (1)
- Solar energy (1)
- Somatostatin receptor expression (1)
- Sonderpädagogik (1)
- Song Huizong <China, Kaiser> (1)
- Songdynastie <960-1279> (1)
- Sonnenblumen (1)
- Sourcing (1)
- South Africa (1)
- Sozial evaluative Situation (1)
- Sozialer Stil des Sprechens (1)
- SpecDis (1)
- Spectral Data Analysis (1)
- Spectroscopy (1)
- Speicherprofil (1)
- Spektrale Interferenz (1)
- Spektroelektrochemie (1)
- Spermatogenese (1)
- SphK1 (1)
- Spheciospongia vagabunda (1)
- Spieltheorie (1)
- Spin-Bahn-Wechselwirkung (1)
- Spin-Transfer-Drehmoment (1)
- Spinal dissemination (1)
- Spindle cell (1)
- Spindrehmoment Bauteil (1)
- Spinnenseide (1)
- Spintronic (1)
- Spinventil (1)
- Spirokohlenwasserstoffe (1)
- Spleißosom (1)
- Spontan Hypertensive Ratte (1)
- Sprache (1)
- Sprachlich-kommunikatives Verhalten (1)
- Sprachmischungen (1)
- Sprechen (1)
- Spred Protein (1)
- Spred-Proteine (1)
- Spumaviren (1)
- Squaraine (1)
- Squaraines (1)
- Src family (1)
- Stabilisierung (1)
- Stadtentwicklung (1)
- Stadtplanung (1)
- Stadtsoziolingusitik (1)
- Stadtsoziologie (1)
- Stanzbiopsie (1)
- Stark korrelierte Fermionen (1)
- Starke Kopplung (1)
- Stationenarbeit (1)
- Staupevirus (1)
- Stem cell (1)
- Sterblichkeit (1)
- Stereology (1)
- Stereotaxie (1)
- Stereotyp (1)
- Sterische Hinderung (1)
- Sternmesogene (1)
- Steuerbarkeit (1)
- Steuerbarkeit von Netzwerken (1)
- Stickstoffmonoxid (1)
- Stiff person syndrome (1)
- Stillen (1)
- Stoffeigenschaft (1)
- Stone-Wales rearrangement (1)
- Stone-Wales-Umlagerung (1)
- Strabismus divergens intermittens (1)
- Strahlenpilze (1)
- Strahlentherapie (1)
- Strahlung (1)
- Strahlungstransport (1)
- Stratafix (1)
- Stress (1)
- Stressreaktion (1)
- Stroke (1)
- Strukturierte Siliziumoberflächen (1)
- Strukturierung (1)
- Strukturoptimierung (1)
- Strukturtreue (1)
- Studie (1)
- Störgeräusch (1)
- Störungstheorie (1)
- Suberin (1)
- Subgroup Discovery (1)
- Subwavelength structures (1)
- Succinylcholine (1)
- Supernova (1)
- Supersymmetry (1)
- Supply Chain (1)
- Supply Chain Design (1)
- Supply Chain Management (1)
- Supply Management (1)
- Supply chain management (1)
- Support-Vektor-Maschine (1)
- Surface plasmons (1)
- Surgery (1)
- Sustainability (1)
- Swine (1)
- Symbiosis (1)
- Synapsine (1)
- Synaptinemal-Komplex (1)
- Synaptotagmin (1)
- Syntax (1)
- Synthesediamant (1)
- Syr Darya (1)
- Syrien (1)
- Systematic review (1)
- Systematischer (Literatur) Review (1)
- Szilvia Rad (1)
- Säugetiere (1)
- Südliche Songdynstie (1)
- Südostasien (1)
- T Cells (1)
- T Zellen (1)
- T cell (1)
- T cell cytotoxicity (1)
- T cell receptors (1)
- T cell rezeptor transfer (1)
- T cell silencing (1)
- T-DM1 (1)
- T-Lymphozyt info (1)
- T-Lymphozyten-Rezeptor (1)
- T-Zell-Rezeptor Transfer (1)
- T-Zelle (1)
- T-Zellrezeptor (1)
- T-antigens (1)
- T-cells (1)
- T-zelle (1)
- T1 quantification (1)
- T1-Quantifizierung (1)
- T6P (1)
- TAMT (1)
- TAVI (1)
- TDM (1)
- TEM (1)
- TERB1 (1)
- TGF (1)
- TH1 (1)
- TH2 (1)
- TLR4 (1)
- TME (1)
- TNF (1)
- TNF α (1)
- TNF-alpha (1)
- TOR (1)
- TP53 mutations (1)
- TRAIL mutants (1)
- TRAILR-Mutants (1)
- TRPM7 kinase (1)
- TYPE-2 (1)
- Tactile (1)
- Tagesklinik (1)
- Tagesrhythmus (1)
- Tagung (1)
- Tansania (1)
- Tanzania (1)
- Tapeworm (1)
- Taxonomie (1)
- Teamwork (1)
- Temozolomide (1)
- Temperaturbeständigkeit (1)
- Terahertzbereich (1)
- Terahertzstrahlung (1)
- Terminal 4q deletion syndrome (1)
- Termiten (1)
- Tertiärstudie (1)
- Tesseract (1)
- Testkonstruktion (1)
- Tetraarylpyracene (1)
- Tetrahydrodicyclopenta[fg,op]tetracen (1)
- Text Mining (1)
- Textilien (1)
- Theoretische Physik (1)
- Therapeutisches Drug Monitoring (1)
- Thermoelektrizität (1)
- Thermometrie (1)
- Thiolase (1)
- Thioredoxin (1)
- Thrombosis (1)
- Tian Shan (1)
- Tight Junction (1)
- Time-dependent Density Functional Theory (1)
- Tisuue Engineering (1)
- Todesrezeptoren (1)
- Toll like receptors (1)
- Toll-like-Rezeptoren (1)
- Topographic guidance (1)
- Topos (1)
- Total knee arthroplasty (1)
- Tourism (1)
- Tourismus (1)
- Trabekuläre Mesenchymale Stammzelle (1)
- Training (1)
- Trajectory tracking (1)
- Transforming Growth Factor beta (1)
- Transgenic mice (1)
- Transient Absorption (1)
- Transient layer (1)
- Transiente Absorption (1)
- Transkriptionsfaktor info (1)
- Transkriptomanalyse (1)
- Transmetallierung (1)
- Transparenzpflichten (1)
- Transplantationsimmunologie (1)
- Transporter SLC5A3 (1)
- Transporter SLC6A6 (1)
- Transposon (1)
- Travelling-salesman-Problem (1)
- Treg (1)
- Triarylamine (1)
- Tribolium castaneum (1)
- Tricarbonylverbindungen (1)
- Tuberkulose (1)
- Tumor microenvironment (1)
- Tumor-Nekrose-Faktor (1)
- Tumor-Nekrose-Faktor / Rekombinantes Protein (1)
- Tumorantigen (1)
- Tumorstoffwechsel (1)
- Tumortherapie (1)
- Tumorzelle (1)
- Tumour markers (1)
- Turbo Spin-Echos (1)
- Twisted gastrulation (1)
- Two-photon absorption (1)
- Two-photon polymerization (1)
- Typ-IV-Allergie (1)
- Tyrosinase (1)
- Tyrosinkinaseinhibitor (1)
- Türkei (1)
- Türkensattel (1)
- U-Bahnlinienplan (1)
- UBZ (1)
- UPEC (1)
- UV-VIS-Spektroskopie (1)
- Ubiquitin (1)
- Ultrafast Spectroscopy (1)
- Ultrafast information processing (1)
- Ultrafast measurements (1)
- Ultrafast spectroscopy (1)
- Ultrakurzer Lichtimpuls (1)
- Ultrakurzzeitlaser (1)
- Ultraschalldiagnostik (1)
- Ultraschnelle Photochemie (1)
- Ultrashort pulse lasers (1)
- Ultrathin Transmission Target (1)
- Ultraviolett-Bestrahlung (1)
- Umweltveränderung (1)
- Uncertainty (1)
- Unerwünschte Arzneimittelwirkung (1)
- Ungarn (1)
- Ungeheuer (1)
- Unionsbürgerschaft (1)
- United States (1)
- University students (1)
- Unmanned Aerial Vehicle (UAV) (1)
- Untergrundtemperaturen (1)
- Ununterscheidbarkeit (1)
- V-ATPasen (1)
- V-Loc (1)
- VEP (1)
- VKORC1 (1)
- VMH (1)
- VOC emissions (1)
- Vaccinia Virus (1)
- Vaccinia virus (1)
- Vaccinia-Virus (1)
- Vacuum stability (1)
- Valenz <Linguistik> (1)
- Valeriana wallichii (1)
- Varianzanalyse (1)
- Variation (1)
- Vascularisation (1)
- Vascularization (1)
- Vaskularisation (1)
- Vaskularisierung (1)
- Vaskulitische Polyneuropathie (1)
- Venlafaxin (1)
- Verbraucherschutzrecht (1)
- Verhalten (1)
- Verhaltenskontrolle (1)
- Verteiltes System (1)
- Vesicles (1)
- Vestibularisschwannom (1)
- Viabilität (1)
- Video Quality Monitoring (1)
- Vienna Forest (1)
- Virtual-reality (1)
- Virtuelle Realität (1)
- Virtuelles Netzwerk (1)
- Virulenz (1)
- Virulenzfaktor (1)
- Virus (1)
- Vision Based (1)
- Visual Tracking (1)
- Visus (1)
- Visus-VEP (1)
- Vitamin K epoxide reductase (1)
- Volkswagen (1)
- Volumenregulation (1)
- Volumentomographie (1)
- Volumenänderungen (1)
- Vor- und Frühgeschichte (1)
- Vorläuferzelle (1)
- Vorläuferzellen (1)
- Voronoi tree map (1)
- Vulgata (1)
- Vulnerable plaque (1)
- Vγ9Vδ2 T cell (1)
- Vγ9Vδ2 T cells (1)
- W355 (1)
- W359 (1)
- WNT pathway (1)
- Wahlen in Indien (1)
- Wahrscheinlichkeitstheorie (1)
- Wald (1)
- Warfarin (1)
- Warning (1)
- Warnung (1)
- Warnungen (1)
- Warsaw breakage syndrome (1)
- WebLogo (1)
- Wechselkurspolitik (1)
- Weiterführende Schulen (1)
- Weltbild Mittelalter (1)
- Werbesprache (1)
- Werk (1)
- Werkstoffeigenschaft (1)
- Wettbewerbsrecht (1)
- Wheelchair (1)
- Wien (1)
- Wiener Klassik (1)
- Wienerwald (1)
- Wirkmechanismus (1)
- Wirkstoff (1)
- Wirkstofffreisetzung (1)
- Wirkstoffspeichersystem (1)
- Wirtschaftsförderung (1)
- Wirtszelle (1)
- Wissenschaftliches Arbeiten (1)
- Wissensextraktion (1)
- Wissenstechnik (1)
- Wnt-Proteine (1)
- Wolfram <von Eschenbach> (1)
- Wortstellung (1)
- Wundheilung (1)
- Wurzel (1)
- X-rays (1)
- Xenopus oocytes (1)
- Y chromosome (1)
- Yaşar Kemal (1)
- YoelII-Nigeriensis (1)
- ZBTB24 (1)
- ZBTB24 mutations (1)
- ZW sex chromosomes (1)
- Zeitabhängige Dichtefunktionaltheorie (1)
- Zeitauflösung (1)
- Zeitreihenanalyse (1)
- Zeitschrift (1)
- Zellassay (1)
- Zelle (1)
- Zellkontakt (1)
- Zellkulturmodell (1)
- Zellmarker (1)
- Zellmarkierung (1)
- Zellmigration (1)
- Zellskelett (1)
- Zellteilung (1)
- Zellvolumen (1)
- Zellüberleben (1)
- Zentralnervensystem (1)
- Zeolith (1)
- Zerebraler Insulinmetabolismus (1)
- Zielgesellschaft (1)
- Zinkchlorin (1)
- Zinn (1)
- Zins (1)
- Zirkulardichroismus (1)
- Zucker (1)
- Zufriedenheit mit PEG (1)
- Zufriedenheitsanalyse (1)
- Zugspitze (1)
- Zutokin (1)
- Zwei-Photonen-Polymerisation (1)
- Zwei-Poren Domänen Kaliumkanäle (1)
- Zweiphotonenabsorption (1)
- Zweisprachigkeit (1)
- Zyklopeptid (1)
- Zytokine (1)
- [18F]Fluorodeoxythymidine (1)
- abdominal aortic-aneurysm (1)
- aberration (1)
- abietane (1)
- abnormalities (1)
- abscisic acid (1)
- abundance (1)
- accessibility (1)
- accumulation (1)
- acetyltransferase RTT109 (1)
- acid dissociation (1)
- acoustic signals (1)
- acrican trypanosomes (1)
- acromiopectoral flap (1)
- actin (1)
- actin filament (1)
- actinomycetes (1)
- actinosporins (1)
- action (1)
- action ability (1)
- action access (1)
- action and perception (1)
- action effects (1)
- action videogaming (1)
- activated receptor-1 (1)
- activating receptors (1)
- active middle-ear implant (1)
- active zone (1)
- activity rhythm (1)
- acupuncture (1)
- acute kidney injury (1)
- acute lymphoblastic leukemia (1)
- acute mania (1)
- acute myelogenous leukemia (1)
- acute myeloid-leukemia (1)
- acute watery diarrhea (1)
- adaptation (1)
- adaptive plasticity (1)
- adaptor protein Swiprosin-1/EFhd2 (1)
- add-on (1)
- additionsvernetzende Silikone (1)
- adduct (1)
- adenocarcinoma of the lung (1)
- adenosine (1)
- adenylyl cyclase (1)
- adenylyl-cyclase isoforms (1)
- adhesion dynamics (1)
- adhesion molecules (1)
- adipose tissue (1)
- adipose tissue engineering (1)
- adolescent (1)
- adoptive transfer (1)
- adrenal glands (1)
- adrenal medulla (1)
- adrenale Steroidogenese (1)
- adrenokortikale Zellen (1)
- adult attention deficit hyperactivity disorder (aADHD) (1)
- adult cardiac myocytes (1)
- advanced therapy medicinal products (1)
- affective state (1)
- afferents (1)
- affinity (1)
- african trypanosomes (1)
- age (1)
- age groups (1)
- age polyethism (1)
- agriculture (1)
- agroecosystems (1)
- albinaria (1)
- albuminuria (1)
- aldosterone (1)
- algorithm (1)
- alignment (1)
- alignment clustering (1)
- all-cause mortality (1)
- allergic rhinitis (1)
- allergy (1)
- allogeneic hematopoietic stem cell transplantation (1)
- allorecognition (1)
- alpaca (1)
- alpha-emitters (1)
- alpha-helical structure (1)
- alpha/delta agonist GFT505 (1)
- ambystoma opacum (1)
- amino acids (1)
- amino groups (1)
- amino-acid-metabolism (1)
- aminocoumarins (1)
- aminopeptidase N (1)
- ampa receptors (1)
- amphibia (1)
- amphibian metamorphosis (1)
- amphiphilic poly(2-oxazoline)s (1)
- amphiphysin (1)
- amplifications (1)
- amygdala (1)
- amyloidosis (1)
- amyotrophic lateral sclerosis (1)
- anaesthetics (1)
- analgesia (1)
- anaplastic large cell lymphoma (ALCL) (1)
- angle resolved photo emission spectroscopy (1)
- angle-resolved photoemission spectroscopy (1)
- anguage and word processing (1)
- anhedonia (1)
- animal behavior (1)
- animal model (1)
- animal models (1)
- ankles (1)
- annecin-V (1)
- annotation (1)
- annual report (1)
- anorexia nervosa (1)
- anspruchsvolle Hörsituation (1)
- ant (1)
- anteriorer Zugang (1)
- anthocyanin derivatives (1)
- anti-CD30 drug conjugate (1)
- anti-infectives (1)
- anti-trypanosoma (1)
- antibiotic (1)
- antibody (1)
- anticipation (1)
- antifungal agents (1)
- antifungals (1)
- antigenetic variation (1)
- antigens (1)
- antiretroviral therapy (1)
- antisense RNA (1)
- antisense RNAs (1)
- antitumor immunity (1)
- anxiety disorders (1)
- apical GLUT2 (1)
- applied physics (1)
- approximation (1)
- april (1)
- arbuscular mycorrhizal fungi (1)
- arctic (1)
- argeted therapy (1)
- arginine (1)
- arlR (1)
- arousal (1)
- arteriovenous loop (1)
- arthropods (1)
- artifact (1)
- aspergillosis (1)
- assay (1)
- association (1)
- astrocytes (1)
- astroparticle (1)
- asymmetric dark matter (1)
- atherogenic dyslipidaemia (1)
- atherosclerotic vascular disease (1)
- atomar kleine Lücke (1)
- atomic-scale gap (1)
- atrophy Kennedys-disease (1)
- attachment glycoprotein (1)
- attention (1)
- attention capture (1)
- attentional bias (1)
- attentional impulsivity (1)
- audiovisual integration (1)
- audiovisual interactions (1)
- audit fees (1)
- audit fees enforcement interim reporting (1)
- auditory brainstem implant (1)
- auditory cortex (1)
- auditory effort (1)
- auditory stimuli (1)
- aurora kinase A polymorphism (1)
- aurorakinase B (1)
- authoring environment (1)
- autism (1)
- autoantibodies (1)
- autoantigen (1)
- autograft (1)
- autoimmunity (1)
- autologous transplantation (1)
- autologous tumor (1)
- autonomes Nervensystem (1)
- autonomic nervous system (1)
- autophagy-related (1)
- autosomal-dominant osteopetrosis (1)
- auxin (1)
- axon regeneration (1)
- axonal integrity (1)
- axonal transport (1)
- axons (1)
- azacitidine (1)
- azines / diazines (1)
- bZIP (1)
- bZIP transcription fators (1)
- bacillus subtilis (1)
- background odor (1)
- bacterial genomes (1)
- bacterial infection (1)
- bacterial pathogens (1)
- banding analyses (1)
- bariatrische Eingriffe (1)
- baryon asymmetry (1)
- bcl-2 associated athanogene protein 3 (1)
- bee pollinators (1)
- behavior (1)
- behavioral activation system (1)
- behavioral conditioning (1)
- benzalkonium chloride (1)
- benzimidazole (1)
- beta (1)
- beta-cyclodextrin (1)
- beta-oxidation (1)
- beta-tubulin (1)
- beta1-adrenergic receptor (1)
- bevacizumab (1)
- bibliometrics (1)
- bibliométrie (1)
- bilingualism (1)
- bimaxillär (1)
- binding protein (1)
- binding proteins (1)
- binge eating (1)
- biochemical characterization (1)
- biodiversity conservation (1)
- biodiversity index (1)
- biodiversity measure (1)
- bioelectrochemistry (1)
- biogenesis (1)
- bioinformatic (1)
- bioinformatics (1)
- bioisosterism (1)
- biology (1)
- biomarkers UPA (1)
- biominarlization proteins (1)
- biophosphonate (1)
- biosynthetic gene-cluster (1)
- bipolar disorders (1)
- bird species richness (1)
- birth rates (1)
- bispidine (1)
- blend (1)
- blood plasma (1)
- blood-stream forms (1)
- blood–brain barrier choline transporter (1)
- body fat (1)
- bond activation (1)
- bone (1)
- bone loss (1)
- bone marrow transplantation (1)
- bone metastasis (1)
- bone-marrow (1)
- bone-mineral density (1)
- bone-targeting radiopharmaceuticals (1)
- bortezomib plus dxamethasone (1)
- borylene (1)
- botanical gardens (1)
- bourgeonal (1)
- bradykinin (1)
- brain computer interface (1)
- brain images (1)
- brain potentials (1)
- brain-computer interfaces (1)
- breakpoint (1)
- breast-cancer cells (1)
- breastfeeding (1)
- bronchial tissue (1)
- brush border membrane (1)
- bryozoan bugula-neritina (1)
- bulky ligands (1)
- bumblebee nest density (1)
- butterfly euphydryas-aurinia (1)
- börsennotierte Gesellschaft (1)
- c-myc (1)
- cAMP (1)
- cGMP (1)
- caffeic acid bornyl ester (1)
- caffein (1)
- calcium (1)
- calcium absorption (1)
- calcium dependent membrane conductance (1)
- calcium homeostasis (1)
- calcium phosphate (1)
- calcium-activated potassium channel (1)
- calcium-phosphate (1)
- calciumabhängige Membranleitfähigkeiten (1)
- cameras (1)
- camponotus aethiops (1)
- campylobacteriosis (1)
- canagliflozin (1)
- cancer cell (1)
- cancer stem cell immunology (1)
- cancer stem cells (1)
- canine (1)
- canine and feline cancer therapy (1)
- capacitance (1)
- capsaicin (1)
- carbohydrate (1)
- carbohydrate chemistry (1)
- carbon metabolism (1)
- carbon monoxide (1)
- carbon nanomaterials (1)
- carcinogen activation (1)
- carcinoma (1)
- cardiac MRI (1)
- cardiac perception (1)
- cardiac surgery (1)
- cardiology (1)
- cardiomyocyte proliferation (1)
- cardiopulmonary exercise testing (1)
- cardiovascular disease (1)
- cardiovascular munster procam (1)
- cardiovascular pharmacology (1)
- cardiovascular risk (1)
- carnivorus plants (1)
- carousel maze (1)
- carriage (1)
- carrier density (1)
- cat (1)
- catechins (1)
- cathepsin (1)
- cathepsin-L (1)
- cations (1)
- celeco - Richtig Lesen Lernen (1)
- cell binding (1)
- cell biology (1)
- cell death (1)
- cell growth (1)
- cell membrane (1)
- cell membranes (1)
- cell penetrating peptides (1)
- cell-adhesion (1)
- cell-cycle arrest cancer therapy (1)
- cellular internalization (1)
- cellular receptor (1)
- cellular therapy (1)
- cement (1)
- central carbon metabolism (1)
- central core disease (1)
- central metabolism (1)
- centromeric instability (1)
- cerebEND (1)
- cereblon expression (1)
- cerebral arteries (1)
- cerebral artery occlusion (1)
- cerebrovascular diseases (1)
- ceriops decandra (1)
- cetuximab (1)
- chaperone Hfq (1)
- charge-coupled device (1)
- chemical diversity (1)
- chemische Modifizierung (1)
- chemotherapy resistance (1)
- chi square tests (1)
- chila catalysis (1)
- chirale Kathalyse (1)
- chlamydia trachomatis (1)
- chlamydomonas flagella (1)
- cholesterol (1)
- cholesterol depletion (1)
- cholinergic interneurons (1)
- chondrocytes (1)
- chromatin (1)
- chromatin assembly factors (1)
- chromosomal aberration (1)
- chromosome evolution (1)
- chronic Hepatitis C (1)
- chronic cerebrovascular disease (1)
- chronic heart failure (1)
- chronic kidney-disease (1)
- chronic myelogenous leukemia (1)
- chronic myeloid leukemia (1)
- chronic phase (1)
- chronic thromboembolic pulmonary hypertension (1)
- ciliary neurotrophic factor (1)
- circadian oscillators (1)
- circadian rhythmicity (1)
- circadian rhythms (1)
- circular dichroism (1)
- circular dichroism spectra (1)
- circular-dichroism (1)
- circulation patterns (1)
- class (1)
- class-I (1)
- classical conditioning (1)
- classification (1)
- claudin-1 (1)
- clausiliidae (1)
- clearance (1)
- cleavage (1)
- climate change (1)
- clinical (1)
- clinical practice guidelines (1)
- clinical study (1)
- clinically isolated syndromes (1)
- clock genes (1)
- cloud (1)
- clumping factor-B (1)
- co-cultivation (1)
- co-evolution (1)
- co-gels (1)
- coagulation (1)
- coagulation factor XII (1)
- coatings (1)
- cochlea (1)
- cochlear implant (1)
- cognitive decline (1)
- cognitive-behavioral therapy (1)
- cognitive-behavioural psychotherapy (1)
- cohesin SMC1-Beta (1)
- cohort studies (1)
- cold stress (1)
- colestilan (1)
- collagens (1)
- colon (1)
- colonies (1)
- colonization (1)
- colony (1)
- colorectal cancer (1)
- columnar architecture (1)
- coma (1)
- comb (1)
- combined immunodeficiency (1)
- combined therapy (1)
- commercial grades (1)
- common genetic determinants (1)
- common variants (1)
- community structures (1)
- comparative molecular field analysis (1)
- comparative molecular similarity index analysis (1)
- complement (1)
- complex-III (1)
- complexation (1)
- component (1)
- components (1)
- compound eye (1)
- computer software (1)
- concept maps (1)
- conceptual change (1)
- condensed matter physics (1)
- condensed-matter physics (1)
- conditioned response (1)
- conifers (1)
- conjugated mycotoxins (1)
- connective tissue (1)
- conservation (1)
- conservation laws (1)
- consortium (1)
- constraints (1)
- contact-kinin system (1)
- contextual conditioning (1)
- contextual fear (1)
- contingency awareness (1)
- continous fields (1)
- contrast-enhanced ultrasound (1)
- convergent extension movements (1)
- conversational analysis (1)
- coordination polymer (1)
- coping (1)
- copy-number alteration (1)
- coronary artery disease (1)
- coronary heart disease (1)
- corpus cavernosum (1)
- correlated electrons (1)
- correlated systems (1)
- correlates (1)
- cortisol (1)
- cosmic ray (1)
- cosmic rays (1)
- cotransporter (1)
- cotton rats (1)
- coulomb coupled quantum dots (1)
- craving (1)
- crop identification (1)
- crop mapping (1)
- crop monitoring (1)
- crop yield (1)
- crops (1)
- crossing minimization (1)
- crossover trial (1)
- crystal-structures (1)
- cues (1)
- cul3 ring ligase (1)
- cultivation (1)
- cultured fibroplasts (1)
- curves (1)
- cutaneous patch (1)
- cycle regulation (1)
- cyclic AMP (1)
- cyclic-AMP (1)
- cyclin-dependent kinases (1)
- cycloaddition (1)
- cyclodextrin (1)
- cyclophsophamide (1)
- cysteine protease (1)
- cystic fibrosis (1)
- cytochrome P450 3A4 (1)
- cytogenetic response (1)
- cytokine (1)
- cytokine responses (1)
- cytokinesis (1)
- cytokinin (1)
- cytokinins (1)
- cytolethal distending toxin (1)
- cytosol (1)
- cytotoxicity receptors (1)
- damage (1)
- damascone (1)
- dark matterWIMP (1)
- dark-matter (1)
- data fusion (1)
- data sharing (1)
- data-bank (1)
- database (1)
- de-novo methylation (1)
- deafness (1)
- death receptors (1)
- decandrinin (1)
- decision making (1)
- declines (1)
- decompensating exophoria (1)
- deep bisulfite sequencing (1)
- deep brain-stimulation (1)
- deer cervus-eldi (1)
- defensive reactivity (1)
- deficient mice (1)
- definition (1)
- deformation (1)
- degradation (1)
- dekompensierende Exophorie (1)
- delay conditioning (1)
- deletions (1)
- demanding hearing situations (1)
- demography (1)
- demyelinating disease (1)
- demyelinating polyradiculoneuropathy (1)
- dendrimer conjugates (1)
- dendritic cells (1)
- dendritic cell (1)
- denritic cells (1)
- density (1)
- density-functional theory (1)
- dentichasmias busseolae (1)
- dependent gene-expression (1)
- deposition (1)
- deprivation (1)
- detection (1)
- determinant (1)
- developing country (1)
- developing oilseeds (1)
- development (1)
- developmental biology (1)
- developmental plasticity (1)
- developmental reprogramming (1)
- dexamethasone (1)
- diabetes (1)
- diabetes mellitus (1)
- dialysate (1)
- dialysepflichtige Niereninsuffizienz (1)
- dialysis (1)
- dialyzer membrane (1)
- diazepam (1)
- dielectric oxides (1)
- different imatinib dose regimens (1)
- differentation (1)
- differential (1)
- differential age distribution (1)
- diffusion (1)
- diffusive component (1)
- digestive system (1)
- digitale Netze (1)
- digitization (1)
- dilation (1)
- dionaea muscipula (1)
- dirac fermions (1)
- direct PCR (1)
- directional RNA-Seq (1)
- disc deseases (1)
- discrimination (1)
- disease-associated (1)
- diseases (1)
- disorder (1)
- distal fixation (1)
- distinct (1)
- divided attention (1)
- documents (1)
- domain (1)
- domains (1)
- dominant optic atrophy (1)
- dopa-induced dyskinesia (1)
- dopamine acetylcholine (1)
- doule blind (1)
- doxorubicin (1)
- dreidimensional (1)
- dreidimensionale Rekonstruktion (1)
- drug (1)
- drug delivery vector (1)
- drug discovery (1)
- drug therapy (1)
- drug-addiction (1)
- drug-drug interactions (1)
- dual-task control (1)
- dung beetle coleoptera (1)
- dye stains-all (1)
- dynamic programming (1)
- dynamical mean field theory (1)
- dynamics (1)
- dyspnea (1)
- dystrophic RCS rats (1)
- e1071 (1)
- eExons (1)
- early applied higher imatinib dosages (1)
- early intervention (1)
- early recognition (1)
- early respiratory-failure (1)
- early response (1)
- early-life (1)
- earnings management (1)
- economic growth (1)
- economy services (1)
- ecosystem service (1)
- ecosystem services (1)
- ecosystemservices (1)
- edema (1)
- education (1)
- educational attainment (1)
- eigenvector centrality (1)
- ejection fraction (1)
- elderly patients (1)
- elderly persons (1)
- electrical excitation (1)
- electrically driven (1)
- electroacupuncture (1)
- electrocorticography (1)
- electroencephalogram (1)
- electroencephalography (1)
- electron density (1)
- electron tunneling (1)
- electronic-structure calculations (1)
- electroporation (1)
- electroweak phase transition (1)
- elektrische Anregung (1)
- elektronische Trainingssysteme (1)
- element (1)
- elevational gradient (1)
- embryo (1)
- embryonic stem cell (1)
- embryos (1)
- emotion (1)
- emotional information (1)
- emotional pictures (1)
- emotional scene stimuli (1)
- emotional sounds (1)
- empagliflozin (1)
- enantioselective (1)
- enantioselektiv (1)
- endocannabinoid release (1)
- endochondral ossification (1)
- endonuclease (1)
- endoplasmatic reticulum (1)
- endothelial cell (1)
- endothelial cells (1)
- endothelial growth factor (1)
- endothelial injury (1)
- endothelial progenitor cells (1)
- endotoxemia (1)
- energies (1)
- energy (1)
- energy bands (1)
- energy signaling (1)
- enforcement (1)
- engagement (1)
- engaging aantibody (1)
- enhance (1)
- enteric nervous system (1)
- enterobacteria (1)
- enteropathy (1)
- envelope (1)
- environment (1)
- environmental cues (1)
- enzyme-linkes immunoassays (1)
- enzymes (1)
- epidemology (1)
- epidural anesthesia (1)
- epidural recording (1)
- epigenetic heterogeneity (1)
- epistemic modality (1)
- epitheliae Barriere (1)
- error monitoring (1)
- erythropoietin (1)
- essential genes (1)
- european birth cohorts (1)
- evaluation (1)
- event related potentials (1)
- event-related FMRI (1)
- evidentiality (1)
- evolutionary mutant model (1)
- exercise (1)
- exome sequencing (1)
- expenditure (1)
- experience sampling (1)
- experimental autoimmune neuritis (1)
- expertise (1)
- expression site attenuation (1)
- extinction (1)
- extinction risk (1)
- extracellular matrix (1)
- eyes (1)
- face (1)
- facial anomalies (1)
- facial expression (1)
- facial expressions (1)
- facial pain (1)
- factor XI (1)
- factor acetylhydrolase activity (1)
- factor-V-Leiden (1)
- fanconi anemia (1)
- fanconi-anemia (1)
- fatty acids (1)
- fatty liver disease (1)
- fear conditioning (1)
- fear potentiated startle response (1)
- feasibility (1)
- femtochemistry (1)
- femtosecond spectroscopy (1)
- fenoterol (1)
- fermions (1)
- ferrocene (1)
- fetal preconditioning (1)
- fibers (1)
- fibrin D-dimer (1)
- fibromyalgia (1)
- filtering (1)
- finder using symmetrical best hits (1)
- fire (1)
- fish (1)
- fission yeast (1)
- flagellar basal body (1)
- flagellum (1)
- flavour symmetry (1)
- flesh (1)
- floating mass transducer (1)
- flowers (1)
- fluorescence in-situ hybridization (1)
- fluorescence microscopy (1)
- fluorescence quenching (1)
- fluorescence resonance energy transfer (1)
- fluorescent protein (1)
- fluoreszenz (1)
- fluticasone propionate (1)
- flux balance analysis (1)
- focal adhesions (1)
- folinic acid (1)
- follow up (1)
- food addiction (1)
- food carving (1)
- food consumption (1)
- food craving (1)
- food pictures (1)
- food-gene interactions (1)
- foraging behavior (1)
- force (1)
- forecasting (1)
- forests (1)
- formica cunicularia (1)
- fragmented landscapes (1)
- framing (1)
- free energy of solvation (1)
- free space (1)
- free survival (1)
- fremdkörper assoziierte Reaktion (1)
- frequencies (1)
- frogs (1)
- fructose (1)
- fruit set (1)
- fruit-quality (1)
- full thickness skin (1)
- fumarate (1)
- functional architecture (1)
- fungal diseases (1)
- fungal pathogens (1)
- fusiform gyrus (1)
- galaxolide (1)
- galbanone (1)
- galectin-1 (1)
- gambling (1)
- gamete (1)
- gamma ray (1)
- gamma rays (1)
- gamma-cyclodextrin (1)
- gamma-ray burst (1)
- gastrointestinal mucositis (1)
- geckos (1)
- gekoppelte Kavitäten (1)
- gels (1)
- gemcitabine (1)
- geminale Rekombination (1)
- gemischte Leukozytenkultur (1)
- gender (1)
- gene polymorphism (1)
- gene therapy (1)
- gene-expression (1)
- gene-expression data (1)
- generalization (1)
- generation (1)
- genes and chromosomes (1)
- genetic deletion (1)
- genetic interference (1)
- genetic modifiers (1)
- genetic variability (1)
- genetics (1)
- genetische Beratung (1)
- genome analysis (1)
- genome-wide association (1)
- genomes (1)
- genomic aberrations (1)
- genomic databases (1)
- genomic response (1)
- genomic stability (1)
- genotoxicity (1)
- geometric mean (1)
- germinative cells (1)
- gesolin function (1)
- gestational age (1)
- gestielte Lappen (1)
- glaucoma (1)
- glaucoma surgery (1)
- global change (1)
- global health (1)
- glucocorticoid receptor (1)
- glucose (1)
- glucose tolerance test (1)
- glutamate decarboxylase 65 (1)
- glutamate dehydrogenase (1)
- glycemic control (1)
- glycogen phosphorylase (1)
- glycogen synthase (1)
- glycoproteins (1)
- glycosome (1)
- go/no-go task (1)
- grade 3B (1)
- grammar (1)
- granulomas (1)
- graph drawing (1)
- grasland (1)
- grasslands (1)
- grb (1)
- group B genotype (1)
- group-A (1)
- growth hormone deficiency (1)
- guanylyl cylcase A (1)
- gut bacteria (1)
- gyrase (1)
- habitat destruction (1)
- habitat patch (1)
- habitat preferences (1)
- habitat quality (1)
- habitats (1)
- haemophilus influenzae (1)
- haemoproteus-columbae (1)
- halichondria panicea (1)
- hand/foot malformation (1)
- hands (1)
- haploidentical γδ T lymphocytes (1)
- haplotypanalysis (1)
- haplotype (1)
- harmonization (1)
- hashimotos-thyroiditis (1)
- head (1)
- head injury (1)
- health (1)
- healthy children (1)
- hearing impairment (1)
- heart rate variability (1)
- heart-failure (1)
- heat conversion (1)
- heat shock response (1)
- heavy fermions (1)
- hela cells (1)
- helitron (1)
- helminth infection (1)
- helper T-cells (1)
- hematologic malignancies (1)
- hematopoietic cell transplantation (1)
- hemodialysis (1)
- hemolytic-uremic syndrome (1)
- heptacellular carcinoma (1)
- herbivores (1)
- hernia (1)
- hernia repair (1)
- heroine (1)
- herpesvirus (1)
- heterodinuclear compound (1)
- heteromolecular interfaces (1)
- heteropathogenicity (1)
- heterotrophic arabidopsis cells (1)
- hexose transporter (1)
- hidden markov-models (1)
- hidden mycotoxins (1)
- hidden-beauty states (1)
- hidden-order (1)
- high calorie (1)
- high denisty lipoprotein (1)
- high numbers (1)
- high-bone-mass (1)
- high-dose chemotherapy (1)
- hippocampal neurons (1)
- histology (1)
- hive (1)
- homeodomain transcription factors (1)
- homologous chromosomes (1)
- homologs (1)
- homology modeling (1)
- homology search (1)
- honey (1)
- honey bees (1)
- honeybee (1)
- honeycomb lattice (1)
- hormones (1)
- hospitalisation (1)
- host cells (1)
- host-cells (1)
- host-pathogen interactions (1)
- human amygdala (1)
- human brain (1)
- human brian endothelium (1)
- human bruchs membrane (1)
- human cells (1)
- human disease (1)
- human evolution (1)
- human immunodeficiency virus (1)
- human impact (1)
- human learning (1)
- human liver cells (1)
- human mineralocorticoid receptor (1)
- human movement (1)
- human multiple-myeloma (1)
- human peripheral blood (1)
- human prostate-cancer (1)
- human receptor kinetics (1)
- human serum albumin (1)
- human sodium iodide symporter (hNIS) (1)
- humanized xenograft model (1)
- humidity (1)
- hunger (1)
- hybrid messenger RNA (1)
- hydrogen regulation (1)
- hydrogen-peroxide (1)
- hyperbolic systems (1)
- hyperkalemia (1)
- hyperphosphataemia (1)
- hyperthermophile (1)
- hypogammaglobulinemia (1)
- hypothalamische Adipositas (1)
- hypotonic (1)
- hypoxia (1)
- iPS Reprogrammierung (1)
- identical twins (1)
- idiopathic inflammatory myopathies (1)
- illness (1)
- illumination (1)
- image correlation spectroscopy (1)
- image properties (1)
- imaginery (1)
- imaging proliferation (1)
- immediate early genes (1)
- immune cell infiltration (1)
- immune escape (1)
- immune modulation (1)
- immune receptors (1)
- immune suppression (1)
- immunoassays (1)
- immunoblotting (1)
- immunocytochemical analysis (1)
- immunodeficiency (1)
- immunosuppression (1)
- immunotherapy (1)
- impact (1)
- implementation (1)
- impulsivity (1)
- imunology (1)
- in silico models (1)
- in vitro (1)
- in vitro kinase assay (1)
- in vivo (1)
- in vivo cell expansion (1)
- in-vitro models (1)
- in-vivo expression (1)
- incentives (1)
- incidence (1)
- inconsistencies (1)
- increases atherosclersosis (1)
- incretin secretion (1)
- incus (1)
- independent predictor (1)
- indoleamine 2,3-dioxygenase (1)
- induced impairment (1)
- induced metabolites (1)
- induced obesity (1)
- inducible factor-I (1)
- induction (1)
- infant growth (1)
- infants (1)
- infections (1)
- infinite dimensions (1)
- inflammatory response (1)
- influenza (1)
- infusion (1)
- inhalation anesthetics (1)
- inhibitor (1)
- inhibitor PAI-1 (1)
- inhibitory control (1)
- inhibitory receptors (1)
- injecting drug users (1)
- innate immunity (1)
- innate lymphoid cells (1)
- inner ear (1)
- inplane spectral weight (1)
- insects (1)
- insights (1)
- instensively managed farmland (1)
- instruction (1)
- integration (1)
- intellectual disability (1)
- intentional binding (1)
- interaction networks (1)
- interaction stress and circadian system (1)
- interaction surfaces (1)
- interconnected systems (1)
- interferon (1)
- interferon alpha (1)
- interleukin-6 (1)
- intermittent exotropia (1)
- international cooperation (1)
- interoception (1)
- intervention study (1)
- intestinal microvascular perfusion (1)
- intestinal mucositis (1)
- intranasal corticosteroids (1)
- intraoperative electrocoicography (1)
- intubation time (1)
- invasive candidiasis (1)
- invasive fungal infections (1)
- inversion techniques (1)
- invertebrate herbivory (1)
- investigators (1)
- iodides (1)
- ionic strength (1)
- ipratropium bromide (1)
- irinotecan (1)
- iron limitation (1)
- iron release (1)
- ischemia (1)
- ischemic brain injury (1)
- ischemic-stroke (1)
- island (1)
- isocaloric intake (1)
- isolation (1)
- isotonic (1)
- journal (1)
- judgement bias (1)
- junction (1)
- kallikrein–kinin system (1)
- kardiale MRT (1)
- karyotype (1)
- karyotype evolution (1)
- katydids orthoptera (1)
- ketogenic diet (1)
- keton bodies (1)
- kidney (1)
- kidney disease; (1)
- kidney function (1)
- kinase Syk (1)
- kinematic analysis (1)
- kinematics (1)
- kinin receptor (1)
- klassischer Stil (1)
- knockout mice (1)
- knowledge acquisition (1)
- knowledge of results (1)
- knowledge-based systems (1)
- kolorektales Karzinom (1)
- kombinierte Divergenzoperation (1)
- kommunikative Ressource (1)
- konditioneller Knockout (1)
- labeling (1)
- laboratory environment (1)
- lactate dehydrogenase (1)
- lactate threshold (1)
- lactic acid bacteria (1)
- lactobacillus (1)
- lactose (1)
- laminin receptor (1)
- land cover (1)
- land use (1)
- land-cover (1)
- land-use (1)
- land-use change (1)
- language (1)
- language development (1)
- language mixing (1)
- lanthanides (1)
- laparoscopic cholecystectomy (1)
- larvae (1)
- larval density (1)
- laser microdissection (1)
- latency (1)
- lateraler Zugang (1)
- lead structure optimization (1)
- leaf-cutting ant (1)
- learning (1)
- learning at workstations (1)
- learning curve (1)
- left-ventricular function (1)
- length of stay (1)
- lepidoptera (1)
- leptogenesis (1)
- lesions (1)
- lidocaine (1)
- life cycle (1)
- life history (1)
- life stage (1)
- ligand incompatibility (1)
- ligand trail (1)
- light scattering (1)
- lilial (1)
- limb development (1)
- lineage (1)
- linear regression analysis (1)
- linguistic morphology (1)
- linguistische Pragmatik (1)
- lipid biosynthesis (1)
- lipid rafts (1)
- lipogenesis (1)
- liquid chromatography (1)
- literary function (1)
- live-attenuated influenza vaccine (1)
- live-cell (1)
- living cells (1)
- living vells (1)
- local enhancement (1)
- localization (1)
- localization microscopy (1)
- locally advanced disease (1)
- location behavior (1)
- locked-in state (1)
- logging (1)
- long terminal repeat (1)
- long-term (1)
- long-term depression (1)
- long-term pain (1)
- longevity (1)
- low birth weight (1)
- lower critical solution temperature (1)
- luciferase (1)
- lung (1)
- lung cancer (1)
- lung injury (1)
- lung transplantation (1)
- lung-cancer (1)
- lymph nodes (1)
- lymphoid-tissue (1)
- lymphoid-tissue lymphomas (1)
- m-RNA (1)
- mC (1)
- mCherry (1)
- mRNA level (1)
- mRNA localization (1)
- mRNA-Metabolismus (1)
- mRNA-Spiegel (1)
- mTOR Inhibitor (1)
- machine learning (1)
- macrovascular (1)
- magnetic anisotropy (1)
- magnetic pi flux (1)
- magnetic resonance imaging (1)
- maize kernels (1)
- major depression (1)
- major histocompatibility complex (1)
- malaria (1)
- malaria parasite (1)
- malaria parasites (1)
- malassimilation (1)
- malignant hyperthermia (1)
- malignant transformation (1)
- malt lymphoma (1)
- mammalian development (1)
- mammalian septins (1)
- mammalian target of rapamycin (1)
- mammary gland (1)
- manganese tricarbonyl complexes (1)
- mantel cell lymphoma (1)
- maps (1)
- marcophages (1)
- marine (1)
- marine bacteria (1)
- marine microalgae (1)
- marine natural product (1)
- marine navigation (1)
- marrow plasma cells (1)
- marrow transplantation (1)
- masked mycotoxins (1)
- masked priming (1)
- mass (1)
- mass-flowering crops (1)
- massively multiplayer online role playing games (1)
- mastitis (1)
- maturation (1)
- mean-field theory (1)
- measles virus (1)
- meat (1)
- mechanics (1)
- mechanisms (1)
- medaka (1)
- media geométrica (1)
- medial prefrontal cortex (1)
- medial prefrontal cortex (mPFC) (1)
- medical and biological imaging (1)
- medical research (1)
- medicine (1)
- medida de la biodiversidad (1)
- medium spiny neurons (1)
- meiotic chromosome dynamics (1)
- meiotic chromosomes (1)
- melanoma cell (1)
- melanomas (1)
- melt electrospinning (1)
- membrane characteristics (1)
- membrane organization (1)
- membrane potential (1)
- membrane structures (1)
- membrane-protein topology (1)
- membrans proteins (1)
- memory (1)
- memory consolidation and extinction (1)
- memory errors (1)
- meningococcal disease (1)
- meningococcal lineages (1)
- menschlicher Einfluss (1)
- merocyanine dyes (1)
- mesenchymal stem and stromal cells (1)
- mesenchymal stem cell (1)
- mesenchymal stem cells (1)
- messenger-RNA decay (1)
- messenger-RNA translation (1)
- meta-analysis based orthology (1)
- metabolic flux analysis (1)
- metabolic network (1)
- metabolic profiling (1)
- metabolic syndrome (1)
- metabolisches Netzwerk (1)
- metabolomic changes (1)
- metabolomics (1)
- metal-organic frameworks (1)
- metamagnetism (1)
- metanalysis (1)
- metapopulation (1)
- metformin (1)
- methylphenidate (1)
- metro map (1)
- miR-126 (1)
- miR-21 (1)
- miR-23a cluster (1)
- miRNA 17-92 Cluster (1)
- micro cavity (1)
- microcephaly (1)
- microna profiles (1)
- microtubule motor (1)
- microvascular (1)
- microvilli (1)
- middle-ear surgery (1)
- migration (1)
- mir-203 (1)
- mismatch negativity (1)
- missing self (1)
- mitochondria (1)
- mitochondrial permeability transition pore (1)
- mitofilin (1)
- mitotic chromosomes (1)
- mittelfristige Ergebnisse (1)
- mixed leukocyte culture (1)
- mixed leukocyte reaction (1)
- mobility (1)
- models (1)
- modified mycotoxins (1)
- modis NDVI (1)
- modulating (1)
- modulators (1)
- mole crickets (1)
- molecular biology (1)
- molecular characterization (1)
- molecular diversity (1)
- molecular dynamics (1)
- molecular imaging (1)
- molecular mass (1)
- molecular structure (1)
- molecular-dynamics simulations (1)
- molecule-metal interfaces (1)
- molekulardynamische Simulationen (1)
- monadic composition (1)
- monetary incentive delay task (1)
- monoallelic expression (1)
- monoclonal gammopathy (1)
- monoclonal-antibodies (1)
- monocytes (1)
- monolayers (1)
- monomodige Laser (1)
- monsters (1)
- mood (1)
- morbid obesity (1)
- morbidity of donor region (1)
- morbilliviruses (1)
- morphine (1)
- morphogenesis (1)
- morphogenetic protein (1)
- morphological adaptions (1)
- morphology (1)
- morris water maze (1)
- mortality (1)
- mosquito (1)
- motility disorders (1)
- motoneurons (1)
- mouse model (1)
- mouse models (1)
- multi-terminal devices (1)
- multi-wavelength (1)
- multicellular tumor spheroids (1)
- multidimensional spectroscopy (1)
- multidrug resistance (1)
- multimodal emotion processing (1)
- multiparameter flow-cytometry (1)
- multiparameter flow-cytpmetry (1)
- multiple myeloma (1)
- multiple system atrophy (1)
- multisensory integration (1)
- multivariate analysis (1)
- multivesicular tubule (1)
- murines Modell der aufsteigenden Harnwegsinfektion (1)
- muscular-dystrophy (1)
- mutation (1)
- mycoses (1)
- mycotoxin derivates (1)
- mycotoxin metabolites (1)
- mycotoxins (1)
- myeloperoxidase (1)
- myenteric plexus (1)
- myoglobin assay (1)
- myokardiale Perfusion (1)
- myopathy (1)
- nab-paclitaxel (1)
- nacreous layer formation (1)
- naloxone (1)
- nanoantenna (1)
- nanodiamond (1)
- nanostructures (1)
- napthalene diimide (1)
- narrative of Judith (1)
- native pollinators (1)
- natively unstructured protein (1)
- natural antisense transcripts (1)
- natural enemies (1)
- natural products (1)
- natural variation (1)
- naturnahe Habitate (1)
- ncRNA (1)
- near infrared spectroscopy (1)
- near-field optics (1)
- neoadjuvant chemotherapy (1)
- neonatal brain (1)
- neonatales Pemphigus-Maus-Modell (1)
- neophobia (1)
- nerve fibres (1)
- nesbitti (1)
- nest building (1)
- networked control systems (1)
- networks (1)
- neural activity (1)
- neural stem-cell (1)
- neuralgia (1)
- neurite bridging (1)
- neurite outgrowth inhibitor (1)
- neurobiology (1)
- neuroimaging (1)
- neuron (1)
- neuron migration (1)
- neuronal differentiation (1)
- neuronal precursor cell (1)
- neuronal primary culture (1)
- neuronale Brückenbildung (1)
- neuronale Vorläuferzelle (1)
- neurone (1)
- neuronopathy (1)
- neuropathology (1)
- neuroprosthetic devices (1)
- neuroprotection (1)
- neuropsychology (1)
- neutrino masses (1)
- neutrino mixing (1)
- neutrophil (1)
- next generation sequencing (1)
- nicht-wettbewerbliche Ziele (1)
- nichtgeminale Rekombination (1)
- nichtkarthesische Bildgebung (1)
- nicotinic receptors (1)
- niedrigmaligne (1)
- nilotinib (1)
- nitrite respiration (1)
- nitrogen status (1)
- no correlation (1)
- non competitive goals (1)
- non-Cartesian Imaging (1)
- non-Hodgkin's lymphoma (1)
- non-hodgkins-lymphoma (1)
- non-ionizing radiation (1)
- non-penetrating glaucoma surgery (1)
- non-small cell lung cancer (1)
- non-verbal communication (1)
- noncoding RNAs (1)
- nonhost plant (1)
- nonlinear control (1)
- nonlinear spectroscopy (1)
- novel (1)
- novobiocin (1)
- nuclear import (1)
- nuclear-pore complexes (1)
- nucleobases (1)
- nucleosynthesis (1)
- nucleotide excision-repair (1)
- nutrition education (1)
- nutritional deficiencies (1)
- nympahlidae (1)
- oaks (1)
- obstructive pulmonary disease (1)
- occupancy (1)
- oculomotor dominance (1)
- odor marks (1)
- of-the-literature (1)
- offene Aufgaben (1)
- oilpalm plantation (1)
- oilseed rape (1)
- oilseeds (1)
- older patients (1)
- olfaction (1)
- olfactory bioassay (1)
- oligonucleotides (1)
- olyelectrolyte domains (1)
- oncogenic transformation (1)
- oncolysis (1)
- oncolytic viral therapy (1)
- oncolytic virus (1)
- opioid peptide (1)
- optical physics (1)
- optical spectroscopy (1)
- optimal solution mapping (1)
- optimization (1)
- oral glucose (1)
- oral mucositis (1)
- orbifrontal cortex (1)
- orbital imaging (1)
- organ dysfunktion (1)
- organ-on-a-chip (1)
- organic molecule (1)
- organic photovoltaics (1)
- organic–metal interface (1)
- organotypic (1)
- orthogonal self-assembly (1)
- orthographic representations (1)
- ortholog (1)
- orthology (1)
- orthology network (1)
- oryzias-latipes (1)
- osteoblasts (1)
- osteoclasts (1)
- osteoprogenitor cells (1)
- osteotropism (1)
- output elasticities (1)
- oviedomycin (1)
- oxaliplatin (1)
- oxidative Stressmarker (1)
- oxidative addition (1)
- oxidative and pH dependent regulation (1)
- oxidative stress marker (1)
- oxidative und pH-abhängige Regulation (1)
- oxides (1)
- oxime ligation (1)
- oxygen/glucose deprivation (1)
- p110alpha (1)
- p38MAPK (1)
- p53 expression (1)
- pFADD (1)
- pICln (1)
- paclitaxel (1)
- pain (1)
- pain sensation (1)
- pancreatic cancer (1)
- parallel evolution (1)
- paralyzed patients (1)
- parasite (1)
- parasitic diseases (1)
- parliamentary interaction (1)
- passiv transfer (1)
- passive avoidance (1)
- patellar tendon (1)
- pathogen-associated molecular patterns (1)
- pathogenesis (1)
- pathometabolism (1)
- pathway (1)
- pathways (1)
- patient (1)
- pattern formation (1)
- patterned semiconductor substrates (1)
- patterns (1)
- peak oxygen uptake (1)
- peak power (1)
- pectoralis major flap (1)
- pedicled flaps (1)
- peginterferon alpha-2B (1)
- penetratin (1)
- penile thrombosis (1)
- people (1)
- peptide (1)
- peptide conjugates (1)
- perceived physical environment (1)
- perception-action (1)
- perception-action coupling (1)
- percutaneus endoscopic gastrostomy (1)
- perineurium (1)
- periodontal diseases (1)
- periodontitis (1)
- peripheral T-cell (1)
- peripheral analgesia (1)
- peripheral blood (1)
- peripheral nervous-system (1)
- peripherer Nerv (1)
- permeability (1)
- personality (1)
- pharmaceutical applications (1)
- pharmacokinetic (1)
- pharmacology (1)
- phase unwrapping (1)
- phased metamorphosis (1)
- phenazine (1)
- phenotypic plasticity (1)
- phonology and reading (1)
- phosphatase (1)
- phosphatidylinositol-3-kinase (1)
- phosphoantigen (1)
- phosphodiesterase-4 inhibitor (1)
- phospholipase A(2) (1)
- phospholipid fatty acids (1)
- phosphorylase isozymes (1)
- phosphorylation sites (1)
- photocurrent (1)
- photodynamic therapy (1)
- photoemission spectroscopy (1)
- photoionisation (1)
- photon statistics (1)
- phylogenetics (1)
- phylogeny (1)
- physical activity (1)
- physical properties (1)
- physical sciences (1)
- physics (1)
- phytohormones (1)
- pi3k-signalweg (1)
- pi3kinase (1)
- picture processing (1)
- pines (1)
- pioglitazone (1)
- pixel purity (1)
- pixel size (1)
- place avoidance task (1)
- placebo (1)
- placebo-controlled trial (1)
- plakortide E. (1)
- plakortis halichondroides (1)
- planar cell polarity (1)
- plant community composition (1)
- plant defenses (1)
- plant diversity (1)
- plant hormones (1)
- plant-animal interaction (1)
- plantago lanceolata (1)
- plants response (1)
- plasma D-dimer (1)
- plasma cells (1)
- plasma membrane (1)
- plasma proteins (1)
- plasmid construction (1)
- plasmodium (1)
- plasmon group velocity (1)
- plasmonic waveguides (1)
- plasmonics (1)
- platelet activation factor (1)
- platelet receptor (1)
- platinum (1)
- platinum complex (1)
- platyfish (1)
- pluripotent stem cells (1)
- pneumona virus (1)
- podoplanin (1)
- polarimetry (1)
- pollinators (1)
- polyadenylation sites (1)
- polycistronic transcription (1)
- polyelectrolyte domains (1)
- polyketide synthase gene (1)
- polymavirus (1)
- polymer (1)
- polymerase-chain-reaktion (1)
- polymorphism (1)
- polystyrene (1)
- polyvinyl chloride (1)
- population-based cohort (1)
- populations (1)
- pose estimation (1)
- post-harvest quality (1)
- post-traumatic stress disorder (1)
- posteroinferior occipitotemporal gyrus (1)
- postherpetic neuralgia (1)
- postoperative Phase (1)
- postoperative care (1)
- posttraumatische Belastungsstörung (1)
- potential marker (1)
- poultry (1)
- pre-school children (1)
- predation (1)
- predation risk (1)
- predictive factors (1)
- predictive marker (1)
- predictors (1)
- predicts recovery (1)
- prepositions (1)
- preschool children (1)
- presynapse (1)
- prevalence (1)
- prevention (1)
- prevention program (1)
- prey growth rate (1)
- priapism (1)
- primary biliary-cirrhosis (1)
- primary breast cancer (1)
- primary cells (1)
- primary human hepatocytes (1)
- primary schoolchildren (1)
- prime visibility (1)
- priming (1)
- proboscis extension response (PER) (1)
- procambarus-clarkii (1)
- product specificity (1)
- products (1)
- profile distances (1)
- progener Formenkreis (1)
- progenitors (1)
- prognostic factor (1)
- progressive supranuclear palsy (1)
- prolactin (1)
- promoter region (1)
- promoters (1)
- propionate (1)
- prosoziales Verhalten (1)
- prosthesis (1)
- protease (1)
- protease inhibitor (1)
- protein HFQ (1)
- protein binding (1)
- protein crystallography (1)
- protein dynamics (1)
- protein families database (1)
- protein interactions (1)
- protein secondary structure (1)
- protein structure (1)
- protein synthesis (1)
- protein-RNA recognition (1)
- protein-bound solutes (1)
- protein-coupled-receptors (1)
- protein-ligand-interaction (1)
- prototypes (1)
- protozoan parasite (1)
- pseudomonas syringae (1)
- psychiatric-hospitalization (1)
- psychiatry (1)
- psycholinguistics (1)
- psychometric properties (1)
- psychopharmacology (1)
- psychosocial stress (1)
- psychotherapy (1)
- psychotic experiences (1)
- pulmonary absorption (1)
- pulmonary artery (1)
- pulmonary artery pressure (1)
- pulmonary circulation (1)
- pulmonary embolism (1)
- pulmonary function (1)
- pulmonata (1)
- pump-probe-spectroscopy (1)
- pupae (1)
- pyracylene (1)
- pyrazine (1)
- pyrrolidine (1)
- périodiques (1)
- qualité (1)
- quantum center (1)
- quantum communications (1)
- quantum control (1)
- quantum criticality (1)
- quantum dot (1)
- quantum dots (1)
- quantum key distribution (1)
- quantum mechanics (1)
- quantum physics (1)
- quantum spin Hall effect (1)
- quantum transport (1)
- quantum-well -wire and -dot devices (1)
- questionaire, day-care, development of children from 13 to 36 months (1)
- questionnaire assessment (1)
- qutenza (1)
- rOCT1 (1)
- race (1)
- radar (1)
- radiation (1)
- radiation-induced migration (1)
- radical prostatectomy (1)
- radio galaxy (1)
- radioiodine therapy (1)
- radiosensibility (1)
- rana temporaria populations (1)
- random forest (1)
- randomisierte Studie (1)
- randomized clinical trial (1)
- randomized controlled-trial (1)
- randomized phase-3 trial (1)
- randomized trial (1)
- randomized-controlled trial (1)
- ranibizumab (1)
- rat hepatocytes (1)
- rat model (1)
- rat small-intestine (1)
- rating scale (1)
- ray solution scattering (1)
- re-aim framework (1)
- reactivation (1)
- reading comprehension test (1)
- reading disability (1)
- reaktive Sauerstoffradikale (1)
- reaktive Sauerstoffspezies (1)
- receptive fields (1)
- receptor (1)
- receptor expression (1)
- receptor gene polymorphism (1)
- receptor related protein (1)
- receptor signaling (1)
- receptor splice variant (1)
- receptor tyrosine kinase (1)
- reciprocal best hit (1)
- recj exonuclease (1)
- recognition (1)
- recombinant proteins (1)
- recommendations (1)
- reconstructed human epidermis (1)
- reconstruction (1)
- recreation-related physical activity (1)
- red blood cells (1)
- red fluorescent protein (1)
- reflection (1)
- reflex (1)
- refractory/relapsed lymphoma (1)
- register (1)
- registration (1)
- regression analysis (1)
- regulation (1)
- regulatory T-cells (1)
- regulatory cells (1)
- regulatory mutations (1)
- regulatory small RNAs (1)
- rehabilitation (1)
- rekombinante Spinnseide (1)
- relevance detection (1)
- reliability (1)
- reminiscence (1)
- remodeling (1)
- remodelling (1)
- remote sequence conservation (1)
- removal (1)
- renal cell carcinoma (1)
- renal disease (1)
- renal failure requiring hemodialysis (1)
- renal system (1)
- rendezvous and docking (1)
- reperfusion injury (1)
- replacement (1)
- replication fork (1)
- replicative stress (1)
- reporter genes (1)
- reprogramming (1)
- requency (1)
- research funds (1)
- research priorities (1)
- resensitization (1)
- residual cardiovascular risk (1)
- resonant photoelectron spectroscopy (1)
- resonators (1)
- resource scheduling (1)
- resource use (1)
- response inhibition (1)
- response regulator (1)
- ressourcenarme Länder (1)
- resting NK cells (1)
- resting-state fMRI (1)
- restrained eaters (1)
- retinal pigment epithelium (1)
- retinotopic organization (1)
- rett (1)
- reward (1)
- reward deficiency syndrome (1)
- rheumatoid arthritis (1)
- rhizophoraceae (1)
- rhodesain (1)
- rhythms (1)
- ribosomal RNA (1)
- ribosome biogenesis (1)
- riboswitch (1)
- riesgo de extinción (1)
- ring-opening polymerization (1)
- risk behavior (1)
- risk profiling (1)
- robust (1)
- rod-to-sphere transition (1)
- roentgenographic assessment (1)
- rofumilast (1)
- roles (1)
- rolling-circle transposons (1)
- root (1)
- roquin (1)
- rtPA (1)
- rumination (1)
- rupture (1)
- ryanodine receptor gene (1)
- s-phase (1)
- sRNA (1)
- saccades (1)
- saccharmyces cerevisiae (1)
- saccharomyes cerevisiae (1)
- safety (1)
- salicylic acid (1)
- salt (1)
- salt stress (1)
- sample (1)
- saproxylic Coleoptera (1)
- sarcoplasmic reticulum (1)
- satellite (1)
- scale (1)
- scar revision surgery (1)
- scavender receptor (1)
- schistosomiasis (1)
- scientific computing (1)
- scoring functions (1)
- scoring system (1)
- screening (1)
- seasonal influenza (1)
- secondary (1)
- secondary metabolomics (1)
- secondary structure (1)
- secreted effector protein (1)
- sections (1)
- see (1)
- seed (1)
- segmentation (1)
- selection (1)
- selective attention (1)
- self-assembly (1)
- self-organization (1)
- self-regulation (1)
- semi-natural habitats (1)
- semiconductor surfaces (1)
- semiotics (1)
- semitendinosus (1)
- sense of agency (1)
- sensitivity (1)
- sensorimotor rhythms (1)
- sequence databases (1)
- sequence motif analysis (1)
- sequences (1)
- sequential introduction (1)
- serotonin (1)
- serotonin transporter gene (1)
- serotonin(1A) receptor (1)
- serum (1)
- sevelamer (1)
- severe fibrosis (1)
- severe sepsis (1)
- sevoflurane (1)
- sex (1)
- sex addiction (1)
- sex determination (1)
- sex-determining region (1)
- shannon index (1)
- shelf life (1)
- shiga toxin (1)
- shingles (1)
- shuttle run test (1)
- signal filtering (1)
- signal transduction (1)
- signal-transduction systems (1)
- signaling (1)
- signaling microdomain (1)
- signaling pathway (1)
- signature (1)
- significance (1)
- significance MGUS (1)
- siliciumhaltige Synthesebausteine (1)
- silicones (1)
- simian foamy viruses (1)
- simpson's index (1)
- single electron transistor (1)
- single molecule microscopy (1)
- single nucleotide polymorphism (1)
- single particle microscopy (1)
- single-nucleotide polymorphisms (1)
- single-stranded-DNA (1)
- single-trial learning (1)
- skeletal metastases (1)
- skeletal muscle (1)
- skeletal myopathy (1)
- skin (1)
- skin tumors (1)
- sleeve gastrectomy (1)
- slowly-binding reversible inhibitor (1)
- small RNA (1)
- small non-coding RNAs (1)
- small nucleolar RNAs (1)
- small organic osmolytes (1)
- small-angle scattering (1)
- small-gain (1)
- smoldering multiple-myeloma (1)
- snow (1)
- snow cover (1)
- snow cover duration (1)
- social actions (1)
- social anxiety (1)
- social communication (1)
- social science research (1)
- socio-demographic (1)
- socioeconomic (1)
- sodium channels (1)
- sofosbuvir (1)
- soft tissue profile (1)
- soleus muscles (1)
- solubility (1)
- soluble-RNAs (1)
- somatic marker hypothesis (1)
- sound production (1)
- spacer (1)
- spatial attention (1)
- species diversity (1)
- species gastropoda (1)
- species richness (1)
- species-energy-theory (1)
- spectroscopy (1)
- spectrum disorder (1)
- speech (1)
- sperm DNA methylation (1)
- spermatocytes (1)
- sphingomyelinase (1)
- spiders (1)
- spin torque device (1)
- spin valve (1)
- spin-orbit coupling (1)
- spin-transfer torque (1)
- spinal cord (1)
- spinal-cord-injury (1)
- spintronics (1)
- spiro hydrocarbons (1)
- spleen (1)
- spliceosomes (1)
- splicing factors (1)
- sponge holicolona-simulans (1)
- sponge-associated actinomyetes (1)
- spontaneously hypertensive rats (1)
- sports and exercise medicine (1)
- spray (1)
- spread (1)
- squalius alburnoides (1)
- stability (1)
- stable-isotope (1)
- stake building (1)
- standardized food images (1)
- starch (1)
- statement (1)
- statische Lokalisierung (1)
- stem cell niche (1)
- stem cells (1)
- stem-cell niche (1)
- sterisch anspruchsvolle Liganden (1)
- stiffness (1)
- stimulated (1)
- stimulation (1)
- stomach (1)
- strawberry (1)
- stream (1)
- streptomyces (1)
- striate cortex (1)
- structure prediction (1)
- structure-activity relationship (1)
- study-group ADSR (1)
- subcellular localization (1)
- subcutaneous fat layer (1)
- subfoveal choroidal neovascularization (1)
- subgroup-B (1)
- subkutan / subcutaneous (1)
- subretinal space (1)
- substance dependence (1)
- substance use disorder (1)
- substrate specificity (1)
- subunit (1)
- succinylcholine (1)
- sucrose responsiveness (1)
- sucrose sensitivity (1)
- sugar absorption (1)
- sulfonylurea (1)
- sunflowers (1)
- super-resolution microscopy (1)
- supercoiling (1)
- supermolecular carrier systems (1)
- supernovae (1)
- superresolution (1)
- supramolecular chemistry (1)
- surface morphology (1)
- surface proteins (1)
- surface water (1)
- surgery (1)
- surgical and invasive medical procedures (1)
- susceptibility loci (1)
- sustained virological response (1)
- suxamethonium (1)
- symbiotic bacteria (1)
- symbiotic fungus (1)
- symptoms (1)
- synapse (1)
- synapse structure (1)
- synapsis (1)
- synaptic localization (1)
- syndrome (1)
- synergistische Effekte (1)
- syntaktische Funktion (1)
- syntaktische Struktur (1)
- synthase (1)
- synthetase (1)
- synthetic D-glucose analogy (1)
- synthetic lethality (1)
- synthetische Letalität (1)
- systematics (1)
- systemic sclerosis (1)
- systems (1)
- systems biology (1)
- t-CWT (1)
- tDCS (1)
- tandem mass-spectra (1)
- target recognition (1)
- targeted metabolite profiling (1)
- targeting (1)
- task switching (1)
- taxonomy (1)
- technological constraints (1)
- teeth (1)
- teichoic acids (1)
- telomere attachment (1)
- temperate forests (1)
- temporal spillover (1)
- temporal-lobe epilepsy (1)
- tension (1)
- terahertz radiation (1)
- term fenofibrate therapy (1)
- term-follow-up (1)
- termites (1)
- tertiary lymphoid structures (1)
- test development (1)
- testis (1)
- tetraaryl pyracene (1)
- tetrahydrodicyclopenta[fg,op]tetracene (1)
- tettigoniidae (1)
- th1/th2 polarization (1)
- thalidomide maintenance (1)
- therapeutic options (1)
- thermoelectrics (1)
- thermoregulation (1)
- thoracic diaphragm (1)
- three-dimensional microscopy (1)
- three-dimensional quantitative structure–activity relationship (1)
- thrombin (1)
- thrombosis (1)
- thyroid (1)
- time series analysis (1)
- time to exhaustion (1)
- time-resolved optical spectroscopy (1)
- time-resolved spectroscopy (1)
- tissue (1)
- tissue characterization (1)
- tissue engineering (1)
- tissue morphogenesis (1)
- tissue-specific enhancers (1)
- tolerance (1)
- tool (1)
- topography (1)
- topological insulator (1)
- torsional energy (1)
- total HIP-arthroplasty (1)
- tousled-like kinases (1)
- toxin (1)
- toxins (1)
- trabecular bone (1)
- trabecular bone-derived mesenchymal stem cell (1)
- trace conditioning (1)
- traction (1)
- trail-mediated apoptosis (1)
- transcranial magnetic stimulation (1)
- transcranial magnetic stimulation (TMS) (1)
- transcription factor FOXP1 (1)
- transcription factor MIZ-1 (1)
- transcriptional start site (1)
- transcriptional uni (1)
- transcriptome analysis (1)
- transcripts (1)
- transfection (1)
- transfer RNA-synthetases (1)
- transformation (1)
- transgenic mice (1)
- transient global ischemia (1)
- transient receptor potential vanilloid 1 (TRPV1) (1)
- transient spectroscopy (1)
- transition metal oxides (1)
- transition metals (1)
- transition state (1)
- translation (1)
- translesion synthesis (1)
- translocation (1)
- transmission electron microscopy (1)
- transmission model (1)
- transport (1)
- transport inhibition assay (1)
- transport systems (1)
- transport-related physical activity (1)
- transposition (1)
- transposon mutagenesis (1)
- treatment options (1)
- tree plantations (1)
- trees (1)
- triarylamine (1)
- trigeminal nerve (1)
- trigeminal neuropathy (1)
- triglyceride accumulation (1)
- triglyceride-rich lipoproteins (1)
- trimethyl-β-cyclodextrin (1)
- tropical dry forest conservation (1)
- tropical ecology (1)
- tropical forest (1)
- tropische Ökologie (1)
- trypanosoma brucei (1)
- tube nutrition (1)
- tumor dormancy (1)
- tumor immune escape (1)
- tumor immunology (1)
- tumor immunosurveillance (1)
- tumor stem cells (1)
- tumor suppressor genes (1)
- tumor tissue (1)
- tumor treatment (1)
- tumor-propagating cells (1)
- tumors (1)
- tundra (1)
- two photon interference (1)
- two-color microscopy (1)
- two-pore domain potassium channels (1)
- type-1 diabetes mellitus (1)
- type-2 diabetes mellitus (1)
- tyrosine phosphorylation (1)
- tyrosine-protein kinase (1)
- ubiquitin (1)
- ultra high energy (1)
- ultra-high risk (1)
- ultrafast measurements (1)
- ultrafast photochemistry (1)
- ultrafast spectroscopy (1)
- unconscious processing (1)
- under five children (1)
- undetermined significance MGUS (1)
- ungegenständliche Erfahrungen (1)
- unilateral recess-resect surgery (1)
- unimaxillär (1)
- universality (1)
- unstructured proteins (1)
- urban-rural gradient (1)
- uremic toxin (1)
- urinary-tract-infection (1)
- uropathogenic Escherichia coli (1)
- utilization (1)
- vaccination (1)
- vaccine (1)
- vaccine development (1)
- vaccinia virus (1)
- vacuolar proton-ATPase (1)
- validity (1)
- variant detection (1)
- variant surface glycoprotein (1)
- variant surface glycoprotein (VSG) (1)
- variants (1)
- vascular access (1)
- vascularization (1)
- vascularized fat construct (1)
- vector cloning (1)
- vegetation phenology (1)
- vegetative state (1)
- velocity (1)
- venous thromboembolic disease (1)
- venous thrombosis (1)
- ventral stream (1)
- ventrikuläre Tachykardie (1)
- verdeckter Beteiligungsaufbau (1)
- vernetze lineare Systeme (1)
- vesicles (1)
- vibration (1)
- vibrational spectroscopy (1)
- vibrio parahaemolyticus (1)
- video gaming masked stimuli (1)
- video-game (1)
- vigilance decrement (1)
- viral clearance (1)
- viral entry (1)
- viral microRNAs (1)
- viral replication (1)
- viral transmission and infection (1)
- virtual screening (1)
- virulence factors (1)
- virulence genes (1)
- virus infection (1)
- virus-infected cells (1)
- visceral fat (1)
- visual cues (1)
- visual learning (1)
- visual perception (1)
- visual resolution deficit (1)
- visual stimuli (1)
- visual-attention (1)
- visuo-motor coordination abilities (1)
- vitro contracture test (1)
- vocabulary (1)
- volatile anesthetics (1)
- volatiles (1)
- voluntary service (1)
- vorsprachliche Entwicklung (1)
- waggle dance (1)
- walking (1)
- wavelet (1)
- weight-gain (1)
- weite Abstimmbarkeit (1)
- well-being (1)
- wheeze (1)
- wheezing (1)
- wild (1)
- wild bees (1)
- wild-type (1)
- word form area (1)
- word order (1)
- work economy (1)
- working memory (1)
- world of warcraft (1)
- worm (1)
- wound healing (1)
- xanthurenic acid (1)
- xeroderma-pigmentosum (1)
- xiphophorus maculatus (1)
- zebrafish (1)
- zeitlicher Spillover (1)
- Ökonometrie (1)
- Ökosystem (1)
- Ökotourismus (1)
- Ölpalmenanbau (1)
- Überexpression (1)
- Übergangsmetallborylen, Borylentransfer, Basenstabilisiertes Borylen, Metathese (1)
- Übergangsmetallkomplexe (1)
- Übergangsmetallverbindungen (1)
- Überlebensrate dentaler Implantate (1)
- Übernahmestrategie (1)
- Übertragbarkeit (1)
- évaluation (1)
- índice de biodiversidad (1)
- γ-glutamyl cycle (1)
- γδ T-Zellen (1)
Institute
- Theodor-Boveri-Institut für Biowissenschaften (124)
- Graduate School of Life Sciences (62)
- Universität - Fakultätsübergreifend (50)
- Physikalisches Institut (38)
- Institut für Psychologie (35)
- Medizinische Klinik und Poliklinik I (35)
- Medizinische Klinik und Poliklinik II (34)
- Neurologische Klinik und Poliklinik (27)
- Klinik und Poliklinik für Psychiatrie, Psychosomatik und Psychotherapie (26)
- Institut für Molekulare Infektionsbiologie (25)
Schriftenreihe
Sonstige beteiligte Institutionen
- Clinical Trial Center (CTC) / Zentrale für Klinische Studien Würzburg (ZKSW) (3)
- Röntgen Center for Complex Material Systems (RCCM), Am Hubland, 97074 W¨urzburg, Germany (2)
- Universitätsklinikum Münster (2)
- Wilhelm-Conrad-Röntgen-Forschungszentrum für komplexe Materialsysteme (2)
- Auftrag der Rummelsberger Dienste für Menschen mit Behinderung gGmbH; Aktion Mensch (1)
- Badisches Landesmuseum Karlsruhe (1)
- CBIO, University of Cape Town, South Africa (1)
- Centre for Political Studies, Jawaharlal Nehru University, New Delhi (1)
- Comprehensive Hearing Center, Department of ORL, Plastic, Aesthetic and Reconstructive Head and Neck Surgery, Würzburg, Germany (1)
- DLR (1)
ResearcherID
- I-5818-2014 (1)
The composition of stable-isotope labelled isotopologues/isotopomers in metabolic products can be measured by mass spectrometry and supports the analysis of pathways and fluxes. As a prerequisite, the original mass spectra have to be processed, managed and stored to rapidly calculate, analyse and compare isotopomer enrichments to study, for instance, bacterial metabolism in infection. For such applications, we provide here the database application ‘Isotopo’. This software package includes (i) a database to store and process isotopomer data, (ii) a parser to upload and translate different data formats for such data and (iii) an improved application to process and convert signal intensities from mass spectra of \(^{13}C\)-labelled metabolites such as tertbutyldimethylsilyl-derivatives of amino acids. Relative mass intensities and isotopomer distributions are calculated applying a partial least square method with iterative refinement for high precision data. The data output includes formats such as graphs for overall enrichments in amino acids. The package is user-friendly for easy and robust data management of multiple experiments.
A novel magnetic ground state is reported for the Hubbard Hamiltonian in strained graphene. When the chemical potential lies close to the Dirac point, the ground state exhibits locally both the Neel and ferromagnetic orders, even for weak Hubbard interaction. Whereas the Neel order parameter remains of the same sign in the entire system, the magnetization at the boundary takes the opposite sign from the bulk. The total magnetization vanishes this way, and the magnetic ground state is globally only an antiferromagnet. This peculiar ordering stems from the nature of the strain-induced single-particle zero-energy states, which have support on one sublattice of the honeycomb lattice in the bulk, and on the other sublattice near the boundary of a finite system. We support our claim with the self-consistent numerical calculation of the order parameters, as well as by the Monte Carlo simulations of the Hubbard model in both uniformly and nonuniformly strained honeycomb lattice. The present result is contrasted with the magnetic ground state of the same Hubbard model in the presence of a true magnetic field (and for vanishing Zeeman coupling), which is exclusively Neel ordered, with zero local magnetization everywhere in the system.
Mutations in the oncogenic PIK3CA gene are found in 10-20% of colorectal cancers (CRCs) and are associated with poor prognosis. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and agonistic TRAIL death receptor antibodies emerged as promising anti-neoplastic therapeutics, but to date failed to prove their capability in the clinical setting as especially primary tumors exhibit high rates of TRAIL resistance. In our study, we investigated the molecular mechanisms underlying TRAIL resistance in CRC cells with a mutant PIK3CA (PIK3CA-mut) gene. We show that inhibition of the constitutively active phosphatidylinositol-3 kinase (PI3K)/Akt signaling pathway only partially overcame TRAIL resistance in PIK3CA-mut-protected HCT116 cells, although synergistic effects of TRAIL plus PI3K, Akt or cyclin-dependent kinase (CDK) inhibitors could be noted. In sharp contrast, TRAIL triggered full-blown cell death induction in HCT116 PIK3CA-mut cells treated with proteasome inhibitors such as bortezomib and MG132. At the molecular level, resistance of HCT116 PIK3CA-mut cells against TRAIL was reflected by impaired caspase-3 activation and we provide evidence for a crucial involvement of the E3-ligase X-linked inhibitor of apoptosis protein (XIAP) therein. Drugs interfering with the activity and/or the expression of XIAP, such as the second mitochondria-derived activator of caspase mimetic BV6 and mithramycin-A, completely restored TRAIL sensitivity in PIK3CA-mut-protected HCT116 cells independent of a functional mitochondrial cell death pathway. Importantly, proteasome inhibitors and XIAP-targeting agents also sensitized other CRC cell lines with mutated PIK3CA for TRAIL-induced cell death. Together, our data suggest that proteasome-or XIAP-targeting drugs offer a novel therapeutic approach to overcome TRAIL resistance in PIK3CA-mutated CRC.
Einen Satz syntaktisch zu analysieren heißt, ein Satzverstehen nach bestimmten Kriterien offenzulegen. Jeder Satzanalyse geht ein grundsätzliches, voranalytisch verborgenes Verstehen ebenso voraus, wie der Prozess der Analyse ein solches Verstehen konkretisiert und ausdrücklich festzurrt: Ohne Verstehen keine Analyse. Für Analysen, die ein Satzverstehen syntaktisch explizieren sollen, benötigt man einen theoretischen Hintergrund, der die Analysewerkzeuge bereitstellt: Ohne Beschreibungsmittel keine Analyse. Schließlich braucht jede Analyse auch noch eine Darstellungsmethode: Ohne Festhalten der Ergebnisse kein Zugriff auf die Analyse.
Der vorliegende Band versteht sich als eine Explikation von Satzverstehen anhand eines konkreten, valenzorientierten Beschreibungsinventars. Im Vordergrund stehen dabei die Visualisierungen der Analyse-Ergebnisse durch Baumgraphen. Über 100 Bäumchen sind hier zu einem Wald versammelt. Damit ist insbesondere (aber nicht nur) für Studierende, die nach dieser Methode Sätze analysieren, eine Möglichkeit gegeben, einen valenz- und dependenzgrammatischen Zugriff auf verschiedene syntaktisch beschreibbare Phänomene authentischen Sprachvorkommens zu erproben. Darüber hinaus stellt der „Würzburger Wald“ unter Beweis, dass die in diesem Band intensiv angewandte Analysemethode ein stabiles Instrument für adäquate syntaktische Analysen sprachlicher Einheiten aus der freien Wildbahn journalistischer Textproduktion ist.
Words are built from smaller meaning bearing parts, called morphemes. As one word can contain multiple morphemes, one morpheme can be present in different words. The number of distinct words a morpheme can be found in is its family size. Here we used Birth-Death-Innovation Models (BDIMs) to analyze the distribution of morpheme family sizes in English and German vocabulary over the last 200 years. Rather than just fitting to a probability distribution, these mechanistic models allow for the direct interpretation of identified parameters. Despite the complexity of language change, we indeed found that a specific variant of this pure stochastic model, the second order linear balanced BDIM, significantly fitted the observed distributions. In this model, birth and death rates are increased for smaller morpheme families. This finding indicates an influence of morpheme family sizes on vocabulary changes. This could be an effect of word formation, perception or both. On a more general level, we give an example on how mechanistic models can enable the identification of statistical trends in language change usually hidden by cultural influences.
This thesis explores the influence of social and environmental cues on the nest building behavior of leaf-cutting ants. Especially, the investigations are aimed at evaluating the mechanisms of nest building and how the nest environment can spatially guide building responses that lead to an adaptive nest architecture. The emergence of nest chambers in the nest of the leaf-cutting ant Acromyrmex lundi were evaluated. Rather than excavating nest chambers in advance, at places where workers encounter suitable environmental conditions for brood and fungus rearing, these items have to be present at a site. When presented in the laboratory with a choice between two otherwise identical digging sites, offering suitable environmental conditions, but one containing brood, the workers displayed a higher excavation activity at the site where they encountered the putative content of a chamber. The shape of the excavated cavity was also more round and chamber-like. It is concluded that leaf-cutting ants respond to social cues during nest building. Excavation is a costly process and colonies have to spend a part of their energy stores on nest building, so that regulatory responses for the control of nest excavation are expected to occur. Worker density at the beginning of the digging process influenced digging activity while the presence of in-nest stores did not. Stored brood and fungus did however influence the architecture of the excavated nest, leading to the excavation of larger chambers and smaller tunnels. While self-organized mechanisms appear to be involved in the nest building process, the social cues of the ants’ environment during building clearly influence the nest architecture and lead to an adjustment of the nest size to the current space needs of the colony. Workers secondarily regulated nest size by the opportunistic refilling of unused space with excavated soil pellets. As the ants should provide suitable conditions for brood and fungus rearing, they should show a behavioral response to CO2 concentrations, as the gas is known to hinder fungus respiration. Workers of A. lundi did indeed avoid high CO2-levels for fungus rearing but actually preferred CO2-values in the range encountered close to the soil surface, where this species excavates their nests. However, different CO2-levels did not affect their excavation behavior. While fungus chambers make up part of a leaf-cutting ant nest, most leaf-cutting ants of the genus Atta also spent part of the colony’s energy on excavating large, voluminous chambers for waste disposal, rather than scattering the material aboveground. It is expected that leaf-cutting ants also show environmental preferences for waste management. In experiments Atta laevigata workers preferred deposition in a warm and dry environment and showed no preference for specific CO2-levels. The continued accumulation of waste particles in a waste chamber seems to be based on the use of volatiles. These originate from the waste itself, and seem to be used as an orientation cue by workers relocating the material. The ensuing large accumulation of waste at one site should result in the emergence of more voluminous chambers for waste disposal.
In den vergangenen Jahren wurden vermehrt sogenannte Alginatersatzmaterialien für Indikationsbereiche entwickelt, für die bislang hauptsächlich Alginate verwendet wurden. In dieser in-vitro Studie wurden acht Alginatersatzmaterialien auf Basis von additionsvernetzenden Silikonen und vier Alginate auf ausgewählte mechanische Werkstoffeigenschaften hin untersucht, um beide Materialarten zu vergleichen und daraus Anwendungsempfehlungen ableiten zu können. Die getesteten Alginate waren Alginoplast Regular Set, Blueprint XCreme, Jeltrate Regular Set und Xantalgin select Fast Set. Die getesteten A-Silikone waren AlgiNot FS Cartridge und Volume, AlginX Ultra Cartridge, Position Penta, Silginat, Status Blue, Xantasil Cartridge und Dynamix fast set. Dabei wurden folgenden Materialeigenschaften untersucht: Verformung unter Druck, Rückstellung nach Verformung, Detailwiedergabegenauigkeit, Dimensionsstabilität, Reißfestigkeit, -dehnung, -energie, Toughness, E-Modul und Homogenität. Die Messverfahren, die verwendet wurden, sind in den Normen DIN EN ISO 4823, DIN EN 21563 und DIN 53504 beschrieben. Zur Messung der Dimensionsstabilität wurde ein neues Verfahren angewendet. Der Vergleich der Homogenität richtete sich nach rein optischen Kriterien der abgebundenen Abformmaterialien.
Die Ergebnisse zeigen, dass die getesteten Alginatsubstitute gegenüber den Alginaten vorteilhafte Eigenschaften besitzen. Alginate sind gegenüber äußeren Kräften nicht annähernd so widerstandsfähig wie Silikone und lassen sich bei gleicher Krafteinwirkung stärker komprimieren (Verformung unter Druck). Alginate sind leichter, aber weniger weit dehnbar (Reißdehnung). Die Alginate reißen bei deutlich geringerer Zugbelastung (Reißfestigkeit), vor allem in Bereichen, in denen das Abformmaterial nur dünn ausgelaufen ist (Toughness). Die elastische Rückstellungsrate der Alginate und von AlgiNot nach Druckbelastung liegt zwar noch im Normbereich, ist jedoch deutlich geringer als bei den anderen Silikonen, welche eine nahezu vollständige Rückstellung aufweisen. Sowohl Silikone als auch Alginate sind prinzipiell in der Lage, auch feinste Strukturen von 20µm Breite gut abzuformen (Detailwiedergabegenauigkeit). Der Versuch zur Messung der Dimensionsänderung zeigt, dass Alginatabformungen selbst unter optimalen Lagerungsbedingungen bereits nach weniger als 24 Stunden so stark geschrumpft sind, dass es ratsam ist die Abformung zu wiederholen. Die Silikone können mit Ausnahme von Silginat mindesten 14 Tage gelagert werden. Für Silginatabformungen wird eine Lagerungsdauer von maximal sieben Tagen empfohlen. Die Beobachtungen zur Homogenität der angemischten Materialien lassen schließen, dass Silikone bei Verwendung von Automischmaschinen besser und gleichmäßiger vermischt werden.
Aufgrund der besseren Materialeigenschaften eignen sich Alginatsubstitute vor allem für Abformungen, die über längere Zeit gelagert werden müssen, bevor ein Gipsmodell hergestellt werden kann und haben den Vorteil, dass aus einer Abformung mehrere Modelle hergestellt werden können. Für die meisten Indikationen genügen die Eigenschaften der Alginate zur Herstellung hinreichend genauer Modelle. Alginate haben außerdem den Vorteil, dass Abformungen mit deutlich geringerer Kraft aus dem Mund entnommen werden können.
Objective: The aim of this longitudinal study was to identify predictors of instantaneous well-being in patients with amyotrophic lateral sclerosis (ALS). Based on flow theory well-being was expected to be highest when perceived demands and perceived control were in balance, and that thinking about the past would be a risk factor for rumination which would in turn reduce well-being.
Methods: Using the experience sampling method, data on current activities, associated aspects of perceived demands, control, and well-being were collected from 10 patients with ALS three times a day for two weeks.
Results: Results show that perceived control was uniformly and positively associated with well-being, but that demands were only positively associated with well-being when they were perceived as controllable. Mediation analysis confirmed thinking about the past, but not thinking about the future, to be a risk factor for rumination and reduced well-being.
Discussion: Findings extend our knowledge of factors contributing to well-being in ALS as not only perceived control but also perceived demands can contribute to well-being. They further show that a focus on present experiences might contribute to increased well-being.
Despite improved survival in the Rituximab (R) era, a considerable number of patients with diffuse large B-cell lymphoma (DLBCL) ultimately die from the disease. Functional imaging using [18F]fluorodeoxyglucose-PET is suggested for assessment of residual viable tumor very early during treatment but is compromised by non-specific tracer retention in inflammatory lesions. The PET tracer [18F]fluorodeoxythymidine (FLT) as surrogate marker of tumor proliferation may overcome this limitation. We present results of a prospective clinical study testing FLT-PET as superior and early predictor of response to chemotherapy and outcome in DLBCL. 54 patients underwent FLT-PET prior to and one week after the start of R-CHOP chemotherapy. Repetitive FLT-PET imaging was readily implemented into the diagnostic work-up. Our data demonstrate that the reduction of FLT standard uptake valuemean (SUVmean) and SUVmax one week after chemotherapy was significantly higher in patients achieving complete response (CR, n=48; non-CR, n=6; p<0.006). Martingale-residual and Cox proportional hazard analyses showed a significant monotonous decrease of mortality risk with increasing change in SUV. Consistent with these results, early FLT-PET response showed relevant discriminative ability in predicting CR. In conclusion, very early FLT-PET in the course of R-CHOP chemotherapy is feasible and enables identification of patients at risk for treatment failure.
In dieser Dissertation wurden zwei Aspekte der Wechselwirkung von Laserpulsen mit Molekülen betrachtet: Erstens wurden numerische Algorithmen, die auf der zeitabhängigen Störungstheorie basieren, zur Berechnung von quantenmechanischen Wellenfunktionen analysiert. Zweitens wurden Effekte der absoluten Phase (Carrier envelope phase = CEP) von Laserpulsen bei der Laseranregung molekularer Systeme analysiert. In den Analysen zum ersten Aspekt wurden zwei verschiedene Algorithmen - in dieser Arbeit als simple und improved algorithm bezeichnet - verwendet, und die Normabweichung von mit diesen Algorithmen berechneten Wellenfunktionen untersucht. Es konnte gezeigt werden, dass diese Normabweichung für beide Algorithmen in zwei unterschiedliche Beiträge zerlegt werden kann. Der erste Normabweichungsbeitrag tritt aufgrund der numerischen Diskretisierung der Zeit auf und verschwindet, wenn der Zeitschritt, der die Dauer der Intervalle für diese Diskretisierung angibt, gegen Null geht. Man kann den ersten Normabweichungsbeitrag mit exzellenter Genauigkeit berechnen und seine Eigenschaften, die sich für die beiden Algorithmen erheblich unterschieden, eingehend analysieren. Der zweite Normabweichungsbeitrag tritt dadurch auf, dass die zeitabhängige Störungstheorie nicht normerhaltend ist, und geht daher gegen Null, wenn die Störungsordnung gegen unendlich geht. Dieser zweite Beitrag ist außerdem in guter Näherung unabhängig vom Zeitschritt und für beide Algorithmen näherungsweise gleich. Des Weiteren kann man das Verhalten des zweiten Normabweichungsbeitrags im Gegensatz zum ersten Beitrag nur qualitativ beschreiben. Für die Analyse zum zweiten Themengebiet dieser Arbeit, den CEP-Effekten, wurde betrachtet, ob CEP-Effekte auch für Laserpulse beliebiger Länge auftreten können. Über eine analytische Betrachtung erkennt man, dass dies für ein Zweiniveausystem nur dann der Fall ist, wenn beide Zustände vor Beginn der Wechselwirkung des Systems mit dem Laserpuls besetzt sind. Man kann aus diesem Ergebnis folgern, dass für einen Laserpuls, der zwei elektronische Zustände eines Moleküls über Einphotonenübergänge koppelt, in der Regel kein CEP-Effekt für beliebige Längen dieses Pulses auftritt. Der Grund dafür ist, dass vor der Wechselwirkung eines molekularen Systems mit einem Laserpuls für dieses üblicherweise nur der elektronische Grundzustand besetzt ist. In dieser Arbeit wird gezeigt, dass dieses Problem durch ein spezielles Zweipulsschema für die Anregung eines molekularen Systems gelöst werden kann. Für dieses Pulsschema wird ein erster Puls verwendet, der zeitlich so kurz ist, dass Wellenpakete in mehreren elektronischen Zuständen angeregt werden. Der nachfolgende zweite Laserpuls ist spektral schmal, und seine zeitliche Länge kann beliebig groß gewählt werden. Man erhält für dieses Pulsschema Observablen, die von der CEP des zweiten Pulses, aber nicht von der CEP des ersten Pulses abhängen; somit ist ein CEP-Effekt nachweisbar. Derartige Observablen sind geometrische Asymmetrien für Zerfallsprodukte von Photodissoziationsreaktionen. Insbesondere unterscheidet sich das hier vorgestellte Pulsschema von anderen Zweipulsschemata, für welche Observablen von der Differenz der CEPs beider Pulse abhängen, aber nicht von der CEP einer der beiden Pulse allein.
Was bedeutet eine Änderung der Kontrastmittelaufnahme in niedrig malignen Gliomen bei Kindern?
(2014)
Bei niedriggradigen Gliomen WHO I° und II° ist das Kontrastmittelverhalten variabel und nicht mit der Prognose assoziiert. Andererseits wurde bei spontanen Regressionen von niedriggradigen Gliomen bei Patienten sowohl mit als auch ohne eine Neurofibromatose Typ I eine Abnahme der Kontrastmittelaufnahme berichtet. Vielleicht deswegen verleitet eine Zunahme des Enhancements oder ein neu aufgetretenes Enhancement nicht selten zur Diagnose einer Tumorprogression. Es stellt sich also die Frage, ob eine Kontrastmittelaufnahme bei LGGs mit einer Größenzunahme somit einem Tumorprogress assoziiert ist.
Es lässt sich eine überdurchschnittliche Assoziation einer Änderung der Kontrastmittelaufnahme mit dem Wachstumsverhalten bei LGGs nachweisen. Allerdings ist das Maß für eine Progression oder Regression weiterhin die Größenänderung des Tumors. Auch eine neue Kontrastmittelaufnahme innerhalb eines Tumors hat keine Bedeutung für das aktuelle Staging. Sie findet sich zwar häufiger bei Wachstum aber auch bei regredienten Tumoren.
Background and Purpose
In animal models, von Willebrand factor (VWF) is involved in thrombus formation and propagation of ischemic stroke. However, the pathophysiological relevance of this molecule in humans, and its potential use as a biomarker for the risk and severity of ischemic stroke remains unclear. This study had two aims: to identify predictors of altered VWF levels and to examine whether VWF levels differ between acute cerebrovascular events and chronic cerebrovascular disease (CCD).
Methods
A case–control study was undertaken between 2010 and 2013 at our University clinic. In total, 116 patients with acute ischemic stroke (AIS) or transitory ischemic attack (TIA), 117 patients with CCD, and 104 healthy volunteers (HV) were included. Blood was taken at days 0, 1, and 3 in patients with AIS or TIA, and once in CCD patients and HV. VWF serum levels were measured and correlated with demographic and clinical parameters by multivariate linear regression and ANOVA.
Results
Patients with CCD (158±46%) had significantly higher VWF levels than HV (113±36%, P<0.001), but lower levels than AIS/TIA patients (200±95%, P<0.001). Age, sex, and stroke severity influenced VWF levels (P<0.05).
Conclusions
VWF levels differed across disease subtypes and patient characteristics. Our study confirms increased VWF levels as a risk factor for cerebrovascular disease and, moreover, suggests that it may represent a potential biomarker for stroke severity, warranting further investigation.
Seit über zwanzig Jahren - mit Inkrafttreten des Vertrages von Maastricht im Jahre 1993 - ist die Unionsbürgerschaft das gemeinsame verbindende Element zwischen den Staatsangehörgien der EU-Mitgliedstaaten und der EU. Die seit der Anfangszeit der EWG anerkannte Rechtssubjektivität des einzelnen Bürgers innerhalb des Gemeinschafts- bzw. Unionsrechts hat dadurch seine endgültige vertragliche Verankerung erfahren. Dabei handelt es sich bei der Unionbürgerschaft nicht nur um ein symbolkräftiges Wortgeschöpf, sondern um ein mit konkreten Bürgerrechten verbundenes Rechtsinstiut. Im Zentrum dieser Bürgerrechte steht die unionsbürgerliche Freizügigkeit. Insofern drängt sich ein Vergleich mit den Freizügigkeitsrechten der etablierten Grundfreiheiten auf. Während letztere nach wie vor Barrieren zwischen den EU-Mitgliedstaaten zugunsten eines gemeinsamen Marktes überwinden wollen, fehlt der unionsbürgerlichen Freizügigkeit jeglicher Marktbezug. Vielmehr dient sie der Verwirklichung des Unionsbürgerstatus selbst. Der einstige sog. Marktbürger, als Mitverwirklicher der Idee des gemeinsamen Marktes, ist also vom Unionsbürger abgelöst worden. Damit ist aber noch nicht die Frage beantwortet, wie sich die unionsbürgerliche Freizügigkeit zu den etablierten Freizügigkeitsrechten verhält. Tritt sie ergänzend neben die traditionellen Grundfreiheiten, gewissermaßen als "Grundfreiheit ohne Markt", oder verbietet sich eine gemeinsame Einordnung unter den Begriff der Grundfreiheiten? Darüber hinaus ist mit Nennung der unionsbürgerlichen Freizügigkeit in der GRCh ihr Verhältnis zu den EU-Grundrechten zu beleuchten, was erneut die Gegenüberstellung von Grundrechten und Grundfreiheiten veranlasst. Letztlich bleiben die Fragen, inwiefern der derzeitige Stand der rechtlichen Lage einen Rückschluss auf die Integrationsentwicklung der Vergangenheit zulässt und - noch entscheidender - inwiefern eine Ordnung der in Rede stehenden Rechtsinstitute eine stabile Basis für die weitere Integrationsentwicklung bilden kann.
The interim reporting process provides decision-useful information to investors and market participants. However the legal circumstances of external interim auditor reviews differ worldwide. A mandatory review rule in the US as opposed to a contrary decision of the German legislator raises the question of the cost-benefit-relation of auditor reviews. Using a German sample of 1,023 firm-year observations from 2007 to 2010, I extract the costs and the benefits of voluntary semi-annual reviews. The unique German legal environment makes it possible to split the cost effect of a review in the price effect (included in audit-related fees) and a possible reduction of audit fees resulting from an improved year-around audit process. I observe a significant increase of audit and audit-related fees of around 14.5% (total fee effect). Additionally, the study provides evidence on declining audit fees for reviewed firms as compared to a matched sample of non-reviewed firms. The effect of an interim review on quarterly earnings quality – using discretionary accruals as an earning management proxy – shows no significant influence.
This study investigates the effect of the error announcement risk on the demand for voluntary interim auditor reviews. Material changes in the German legal environment in 2007 introduced an enforcement system for semi-annual financial reports. The demand for voluntary semi-annual reviews increased significantly from 0.8% in 2006 to 14.6% in 2007 and increased further to 19.5% until 2010 for a sample of 1,278 firm-year observations. This study addresses the question whether the enforcement structure and the resulting error announcement risk exposure have an influence on voluntary external monitoring. After controlling for agency costs, the corporate governance structure, and selected review cost factors, results of a logistic regression analysis show a positive influence of error announcement risk on the likelihood of engaging an auditor to review the semi-annual interim report. The findings contribute to the literature by demonstrating that the quality of the enforcement system and the risk of error findings influence the review decision of the board of directors positively.
In 2004 German legislation established the Financial Reporting Enforcement Panel. In 147 cases since then, the panel has ordered the announcement of errors in previously disclosed and audited financial statements of German firms. We use this unique dataset to evaluate the consequences of increasing earnings management over time on enforcement releases and their recognition in audit fees. Ettredge et al. (2010) provide evidence on a phenomenon called ‘balance sheet bloat’ that is due to income increasing earnings management and later influences the disclosure of misstated financial statements. Thus, the evidence of earnings management recognition in audit fees (Abbott et al. 2006) and the hypothesis of future information content in fees by Stanley (2011) leads us to hypothesize that auditors recognize increasing audit risk in audit fees before the enforcement process starts. We extend related earnings management and audit fee literature by modeling the development of earnings management within the misstatement firms and systematically link it to auditor reactions. We find significant predictive power of different commonly used accrual measures for enforcement releases in the period prior and up to the misstatement period. In this period of time, we also observe an audit fee increase, e.g. the recognition of increased audit risk. We investigate an audit fee effect after the misstatement period but find no significant relation.
Volumenregulatorische Transportwege von anorganischen und organischen Osmolyten in Säugetierzellen
(2014)
Die Aufrechterhaltung des Zellvolumens unter variablen osmotischen Bedingungen stellt für nahezu alle tierischen Zellen eine essenzielle Aufgabe dar. Um regulatorische Volumenanpassungen vorzunehmen besitzen sie daher effektive Mechanismen, mit deren Hilfe der zelluläre Gehalt an organischen und anorganischen Osmolyten erhöht (= regulatorische Volumenzunahme; RVI) oder gesenkt (= regulatorische Volumenabnahme; RVD) werden kann. Trotz langjähriger Forschung auf diesem Gebiet konnten die hieran beteiligten Transportwege für Osmolyte bisher nur unvollständig aufgeklärt werden.
Insbesondere bei T-Lymphozyten sind wichtige Zellfunktionen wie die Proliferation, Migration und die T-Zell-Aktivierung eng mit volumenregulatorischen Mechanismen verbunden. Bei all diesen Prozessen sind u. a. unterschiedliche Kaliumkanäle beteiligt, die insbesondere für die pharmakologische Manipulation von Immunsystemprozessen von wissenschaftlichem Interesse sind. Bisherige Modelle der hypotonen Volumenregulation von T-Lymphozyten berücksichtigen lediglich den spannungsabhängigen KV1.3 sowie den Ca2+-aktivierten IKCa1-Kanal, die zur Klasse der 6TM/P-K+-Kanäle gehören.
Im ersten Teil der vorliegenden Arbeit wurde eine potentielle Rolle von kürzlich entdeckten Zwei-Poren Domänen Kaliumkanälen (K2P) am RVD von murinen und humanen primären CD4+-T-Lymphozyten untersucht. In einem kombinierten genetischen und pharmakologischen Ansatz mittels knockout-Tiermodellen und dem Einsatz kanalspezifischer Inhibitoren konnte mithilfe zellvolumetrischer Analysen gezeigt werden, dass die K2P-Vertreter TASK1, TASK2, TASK3 und TRESK maßgeblich am schwellungsaktivierten Efflux von K+ beteiligt sind. Beurteilt an den Ergebnissen dieser Untersuchung sind der spannungsabhängige TASK2- und der Ca2+-aktivierte TRESK-Kanal für die hypotone Volumenregulation in T-Zellen deutlich bedeutender als TASK1 und TASK3. Der Beitrag der Kanäle TASK2 und TRESK am RVD-Prozess war über dies vergleichbar mit dessen des bisher bekannten KV1.3-Kanals. In dieser Arbeit wurde damit erstmals eine Beteiligung der K2P-Kanäle am RVD muriner und humaner CD4+-Lymphozyten identifiziert. Aufgrund der engen Verbindung zwischen T-Zell-Funktion und der Volumenregulation können Zwei-Poren Domänen K+-Kanäle damit in den engeren Kreis potentieller immunmodulierende Angriffspunkte aufgefasst werden.
Im zweiten und umfangreicheren Teil dieser Arbeit wurden darüber hinaus die schwellungsaktivierten Transportwege für organische Osmolyte (small organic osmolytes; SOOs) untersucht. SOOs stellen chemisch inerte Verbindungen dar, zu denen vor allem Polyole (Sorbitol, myo-Inositol), Methylamine (Betain, α-Glycerophosphocholin) sowie Aminosäuren (α- bzw. β-Alanin und Prolin) und deren Derivate (Taurin) zählen. Da SOOs weder die zelluläre Struktur noch die Funktion von Makromolekülen beeinträchtigen, sind sie wichtige Instrumente der Volumenregulation, die sich in hohen Konzentrationen im Zytosol nahezu aller Zellen wiederfinden. Werden tierische Zellen mit hypotonen Bedingungen konfrontiert, dann ist bei nahezu allen Zellen die Freisetzung organischer Osmolyte zu beobachten, wodurch die zelluläre Osmolarität unabhängig von Elektrolyten angepasst werden kann. Trotz der wichtigen Funktion der SOOs in der Osmoregulation tierischer Zellen konnte die molekulare Identität beteiligter Effluxwege (Kanäle bzw. Transporter) bisher nicht aufgeklärt werden.
Ungeachtet der molekularen Identität der SOO-Effluxwege war es aus zahlreichen biotechnologischen Anwendungen zu Beginn dieser Arbeit bekannt, dass die schwellungsaktivierten Transportwege für organische Osmolyte eine größenselektive Permeabilität für eine Reihe monomerer Zucker und verwandter Verbindungen aufweisen. Um diese Größenselektivität näher zu charakterisieren, wurde im ersten Schritt die schwellungsaktivierte Membranpermeabilität für eine Reihe strukturell homogener Polyethylenglykole unterschiedlicher Polymerlänge (PEG200–1500; hydrodynamische Radien zwischen ~0,5-1,5 nm) unter iso- und hypotonen Bedingungen in Jurkat-Lymphozyten untersucht. Unter milden hypotonen Bedingungen (200 mOsm) war die Plasmamembran der untersuchten Lymphozyten für PEG300-1500 undurchlässig, was aus der Fähigkeit der Zellen zur hypotonen Volumenregulation geschlossen werden konnte. Darüber hinaus wurde RVD in stark hypotonen Lösungen (100 mOsm) mit PEG600-1500 beobachtet, während PEG300-400 unter vergleichbaren osmotischen Bedingungen die Volumenregulation der Zellen inhibierten. Dieses Ergebnis deutet darauf hin, dass starkes hypotones Zellschwellen der Lymphozyten zur Permeabilisierung der Plasmamembran für PEG300-400, nicht jedoch für PEG600-1500, führt. Anhand der hydrodynamischen Radien Rh der verwendeten PEGs konnte ein cutoff-Radius von ~0,74 nm für schwellungsaktivierte Transportwege organischer Osmolyte bestimmt werden. Da diese schwellungsaktivierten Transportwege vielfältig für Zellbeladungstechniken verwendet werden, könnte dieses Ergebnis für zahlreiche biotechnologische und biomedizinische Anwendungen von Interesse sein.
Im zweiten Schritt wurde der Versuch unternommen, potentielle Transportwege für organische Osmolyte im RVD-Prozess molekular zu identifizieren. Da es grundlegend ungeklärt war, wie viele unterschiedliche Transporter bzw. Kanäle am Efflux der zahlreichen organischen Osmolyte beteiligt sind, erfolgte zunächst die vergleichende Analyse des schwellungsaktivierten Membrantransports strukturell verschiedener SOOs einschließlich der Aminosulfonsäure Taurin und des Polyols myo-Inositol. Hierbei wurde erstmals gezeigt, dass die schwellungsaktivierten Transportwege für Taurin und myo-Inositol deutlich unterschiedliche Aktivitätsprofile aufweisen. Während der Taurintransport bereits unter milden hypotonen Bedingungen, d.h. nach einer geringen Absenkung der Osmolalität von 300 auf ~230 mOsm, aktiviert wurde, erfolgte die Aktivierung der Membranpermeabilität für myo-Inositol bei einer viel niedrigeren Osmolalität von ~150 mOsm. Darüber hinaus wiesen die beiden Transportwege unter vergleichbarem hypotonen Stress von 100 mOsm deutlich unterschiedliche Aktivitätsdauern auf (Transport von Taurin ~95 min und myo-Inositol ~40 min). Somit deuteten diese Ergebnisse erstmals auf substrat-spezifische Transportwege für SOOs hin, die voneinander stark abweichende osmotische Aktivierungsprofile besitzen.
Als aussichtsreiche Kandidaten für diese Transportwege wurden zwei Mitglieder der Gruppe der Solute Carrier (SLC) untersucht, die klare Übereinstimmungen mit den gesuchten Transportern für SOOs aufweisen. Daher wurde im Weiteren eine RVD-Beteiligung dieser Transportergruppe mit einer Kombination aus molekularbiologischer und konventioneller bzw. hochaufgelöster mikroskopischen Techniken überprüft. Die semiqantitativen RT-PCR-Ergebnisse dieser Arbeit zeigen dabei, dass die Gentranskription der potentiellen SOO-Transporter SLC5A3 und SLC6A6 in den untersuchten Zelllinien Jurkat, HEK wie auch HepG2-Zellen durch hypotone Bedingungen deutlich verstärkt wird. Hierbei nimmt der zelluläre mRNA-Gehalt der Gene SLC5A3 zwischen 20-60% und SLC6A6 um 30-100% innerhalb von 10-20 min zu, was auf eine potentielle RVD-Beteiligung von SLC-Transportern hindeutet. Ausgehend von diesem Ergebnis wurde daraufhin die zelluläre Lokalisation des SLC5A3-Transporters unter isotonen und hypotonen Bedingungen mikroskopisch untersucht. Wie anhand der konfokalen lasermikroskopischen Untersuchung zu erkennen ist, findet unter hypotoner Stimulation eine zelluläre Umverteilung des mit EGFP fluoreszenzmarkierten Proteins SLC5A3 statt. Innerhalb von 10 min wird der Transporter dabei von intrazellulären Regionen in Richtung Plasmamembran verlagert. Darüber hinaus konnte mit Hilfe der hochauflösenden Mikroskopie-Technik dSTORM gezeigt werden, dass der Transporter SLC5A3 unter hypotoner Stimulation verstärkt mit der Plasmamembran assoziiert vorliegt. Diese verstärkte Membranassoziation des SLC5A3-Proteins deutet damit auf einen schwellungsinduzierten exozytotischen Einbau des Transporters hin.
Die Ergebnisse dieser Arbeit zeigen damit erstmals, dass SLC-Transporter wie SLC5A3, SLC6A6 und vermutlich andere Vertreter der SLC-Superfamilie potentiell am Mechanismus der hypotonen Volumenregulation beteiligt sind. Da SLC-Transporter als wichtige Transportsysteme für Therapeutika angesehen werden und die Mechanismen der Volumenregulation bereits in zahlreichen biotechnologischen Anwendungen implementiert sind, könnte der hier aufgedeckte Zusammenhang einen Erkenntnisgewinn für zahlreiche biomedizinische Forschungsgebiete darstellen.
Background: Different parameters have been determined for prediction of treatment outcome in hepatitis c virus genotype 1 infected patients undergoing pegylated interferon, ribavirin combination therapy. Results on the importance of vitamin D levels are conflicting. In the present study, a comprehensive analysis of vitamin D levels before and during therapy together with single nucleotide polymorphisms involved in vitamin D metabolism in the context of other known treatment predictors has been performed.
Methods: In a well characterized prospective cohort of 398 genotype 1 infected patients treated with pegylated interferon-alpha and ribavirin for 24-72 weeks (INDIV-2 study) 25-OH-vitamin D levels and different single nucleotide polymorphisms were analyzed together with known biochemical parameters for a correlation with virologic treatment outcome.
Results: Fluctuations of more than 5 (10) ng/ml in 25-OH-vitamin D-levels have been observed in 66 (39) % of patients during the course of antiviral therapy and neither pretreatment nor under treatment 25-OH-vitamin D-levels were associated with treatment outcome. The DHCR7-TT-polymorphism within the 7-dehydrocholesterol-reductase showed a significant association (P = 0.031) to sustained viral response in univariate analysis. Among numerous further parameters analyzed we found that age (OR = 1.028, CI = 1.002-1.056, P = 0.035), cholesterol (OR = 0.983, CI = 0.975-0.991, P<0.001), ferritin (OR = 1.002, CI = 1.000-1.004, P = 0.033), gGT (OR = 1.467, CI = 1.073-2.006, P = 0.016) and IL28B-genotype (OR = 2.442, CI = 1.271-4.695, P = 0.007) constituted the strongest predictors of treatment response.
Conclusions: While 25-OH-vitamin D-levels levels show considerable variations during the long-lasting course of antiviral therapy they do not show any significant association to treatment outcome in genotype 1 infected patients.
Modulation of sensorimotor rhythms (SMR) was suggested as a control signal for brain-computer interfaces (BCI). Yet, there is a population of users estimated between 10 to 50% not able to achieve reliable control and only about 20% of users achieve high (80–100%) performance. Predicting performance prior to BCI use would facilitate selection of the most feasible system for an individual, thus constitute a practical benefit for the user, and increase our knowledge about the correlates of BCI control. In a recent study, we predicted SMR-BCI performance from psychological variables that were assessed prior to the BCI sessions and BCI control was supported with machine-learning techniques. We described two significant psychological predictors, namely the visuo-motor coordination ability and the ability to concentrate on the task. The purpose of the current study was to replicate these results thereby validating these predictors within a neurofeedback based SMR-BCI that involved no machine learning.Thirty-three healthy BCI novices participated in a calibration session and three further neurofeedback training sessions. Two variables were related with mean SMR-BCI performance: (1) a measure for the accuracy of fine motor skills, i.e., a trade for a person’s visuo-motor control ability; and (2) subject’s “attentional impulsivity”. In a linear regression they accounted for almost 20% in variance of SMR-BCI performance, but predictor (1) failed significance. Nevertheless, on the basis of our prior regression model for sensorimotor control ability we could predict current SMR-BCI performance with an average prediction error of M = 12.07%. In more than 50% of the participants, the prediction error was smaller than 10%. Hence, psychological variables played a moderate role in predicting SMR-BCI performance in a neurofeedback approach that involved no machine learning. Future studies are needed to further consolidate (or reject) the present predictors.
Staphylococcus aureus is a major threat to public health systems all over the globe. This second most cause of nosocomial infections is able to provoke a wide variety of different types of infection in humans and animals, ranging from superficial skin and skin structure infections to invasive disease like sepsis or pneumonia. But not enough, this pathogen is also notorious in acquiring and/or developing resistance to antimicrobial compounds, thus limiting available treatment options severely. Therefore, development of new compounds and strategies to fight S. aureus is of paramount importance. But since only 1 out of 5 compounds, which entered clinical trials, becomes a drug, the preclinical evaluation of promising compounds has to be reconsidered, too. The aim of this thesis was to address both sides of this problem: first, to improve preclinical testing by incorporating in vivo imaging technologies to the preclinical testing procedure in order to acquire additional and clearer data about efficacy of promising compounds and second, by evaluating lysostaphin, which is a promising, new option to fight S. aureus infections.
The first aim of this thesis focused on the establishment of a dual modality in vivo imaging platform, consisting of Bioluminescence Imaging (BLI) and Magnetic Resonance Imaging (MRI), to offer detailed insights into the course and gravity of S. aureus infection in the murine thigh infection model. Since luciferase-expressing S. aureus strains were generated in former studies and enabled thus bioluminescence imaging of bacterial infection, this technology should be implemented into the compound evaluation platform in order to non-invasively track the bacterial burden over time. MRI, in contrast, was only rarely used in earlier studies to visualize and measure the course of infection or efficacy of anti-bacterial therapy. Thus, the first set of experiments was performed to identify benefits and drawbacks of visualizing S. aureus infections in the mouse model by different MR methods. Native, proton-based MR imaging showed in this regard increased T2 relaxation times in the infected thigh muscles, but it was not possible to define a clear border between infected and uninfected tissue. Iron oxide nanoparticles and perfluorocarbon emulsions, two MR contrast agents or tracer, in contrast, offered this distinction. Iron oxide particles were detected in this regard by their distortion of 1H signal in proton-based MRI, while perfluorocarbon emulsion was identified by 19F MRI. Mammals do not harbor sufficient intrinsic amounts of 19F to deliver specific signal and therefore, 19F MR imaging visualizes only the signal of administered perfluorocarbon emulsion. The in vivo accumulation of perfluorocarbon emulsion can be imaged by 19F MRI and overlayed on a simultaneously acquired 1H MR image, which shows the anatomical context in clear detail. Since this is advantageous compared to contrast agent based MR methods like iron oxide particle-based MRI, further experiments were performed with perfluorocarbon emulsions and 19F MRI.
Experimental studies to elucidate the accumulation of perfluorocarbon emulsion at the site of infection showed robust 19F MR signals after administration between day 2 and at least day 8 p.i.. Perfluorocarbon emulsion accumulated in all investigated mice in the shape of a ‘hollow sphere’ at the rim of the abscess area and the signal remained stable as long as the infection prevailed. In order to identify the mechanism of accumulation, flow cytometry, cell sorting and histology studies were performed. Flow cytometry and cell sorting analysis of immune cells at the site of infection showed that neutrophils, monocytes, macrophages and dendritic cells carried contrast media at the site of infection with neutrophils accounting for the overwhelming portion of perfluorocarbon signal. In general, most of the signal was associated with immune cells, thus indicating specific immune cell dependent accumulation. Histology supported this observation since perfluorocarbon emulsion related fluorescence could only be visualized in close proximity to immune cell nuclei.
After establishing and testing of 19F MRI with perfluorocarbon emulsions as infection imaging modality, the effects of antibiotic therapy upon MR signal was investigated in order to evaluate the capability of this modality for preclinical testing procedure. Thus, the efficacy of vancomycin and linezolid, two clinically highly relevant anti - S. aureus compounds, were tested in the murine thigh infection model. Both of them showed reduction of the colony forming units and bioluminescence signal, but also of perfluorocarbon emulsion accumulation strength and volume at the site of infection, which was visualized and quantified by 19F MRI. The efficacy pattern with linezolid being more efficient in clearing bacterial infection was shown similarly by all three methods. In consequence, 19F MRI with perfluorocarbon emulsion as MR tracer proved to be capable to visualize antibacterial therapy in preclinical testing models.
The next step was consequently to evaluate a promising new compound against S. aureus infections. Thus, lysostaphin, an endo-peptidase that cleaves the cell wall of S. aureus, was tested in different concentrations alone or in combination with oxacillin for efficacy in murine thigh and catheter associated infection models. Lysostaphin only in the concentration of 5 mg/kg body weight or combined with oxacillin in the concentration of 2 mg/kg showed strong reduction of bacterial burden by colony forming unit determination and bioluminescence imaging in both models. The perfluorocarbon accumulation was investigated in the thigh infection model by 19F MRI and was strongly reduced in terms of volume and signal strength in both above-mentioned groups. In general, lysostaphin showed comparable or superior efficacy than vancomycin or oxacillin alone. Therefore, further development of lysostaphin for the treatment of S. aureus infections is recommended by these experiments. Overall, the antibiotic efficacy pattern of all applied antibiotic regimens was similar with all three applied methods, demonstrating the usefulness of MRI for antibiotic efficacy testing. Importantly, treatment with oxacillin either alone or in combination with lysostaphin resulted in stronger perfluorocarbon emulsion accumulation at the site of infection than expected compared to the results from bioluminescence imaging and colony forming unit determination. This might be an indication for immunomodulatory properties of oxacillin.
Further murine infection experiments demonstrated in this context a differential release of cytokine and chemokines in the infected thigh muscle in dependence of the applied antibacterial therapy. Especially treatment with oxacillin, but to a less degree with minocycline or linezolid, too, exhibited high levels of various cytokines and chemokines, although they reduced the bacterial burden efficiently. In consequence, possible immunomodulatory effects of antibacterial compounds have to be taken into account for future applications of imaging platforms relying on the visualization of the immune response. However, this observation opens a new field for these imaging modalities since it might be extraordinary interesting to study the immunomodulatory effects of compounds or even bacterial factors in vivo. And finally, a two modality imaging platform which combines methods to visualize on the one hand the bacterial burden and on the other hand the immune response offers an innovative, new platform to study host-pathogen interaction in vivo in a non-invasive fashion.
In summary, it could be shown that perfluorocarbon emulsions accumulate in immune cells at the site of infection in the murine S. aureus thigh infection model. The accumulation pattern shapes a ‘hollow sphere’ at the rim of the abscess area and its size and perfluorocarbon content is dependent on the severity of disease and/or efficacy of antibiotic therapy. Thus, 19F MRI with perfluorocarbon emulsions is a useful imaging modality to visualize sites and course of infection as well as to evaluate promising antibacterial drug candidates. Furthermore, since the accumulation of tracer depends on immune cells, it might be additionally interesting for studies regarding the immune response to infections, auto-immune diseases or cancer, but also to investigate the efficacy of immunomodulatory compounds and immunization.
Aktive Zonen (AZs) sind hoch spezialisierte, subzelluläre Kompartimente von Neuronen, die der synaptischen Übertragung dienen. Sie enthalten Gerüstproteine wie RIM (Rab3 interacting molecule) sowie elektronendichte Projektionen bestehend aus Bruchpilot bei Drosophila melanogaster oder Bassoon im Säuger, welche Schlüsselkomponenten des Vesikelverkehrs darstellen. Bei der Fliege sind Anzahl und Verteilung von Bruchpilot-Molekülen in AZs relevant für die funktionelle Differenzierung. Ihre Anordnung wird im Abstand von weniger als einem Mikrometer innerhalb einer präsynaptischen Endigung reguliert.
Im Rahmen der vorliegenden Arbeit wurden elektrophysiologische Ableitungen und konfokale sowie höchstauflösende, immunhistochemische Bildgebung mit dem dSTORM (direct Stochastic Optical Reconstruction Microscopy) Verfahren an larvalen, neuromuskulären Synapsen von Drosophila durchgeführt. Dabei wurde das genetische Potenzial des Modellorganismus genutzt, um relevante Proteinfunktionen und -interaktionen zu analysieren.
RIM als zentrale Komponente Aktiver Zonen ist relevant für synaptische Plastizität. Eine als CORD7 (cone-rod dystrophy type 7) bezeichnete Punktmutation (Arginin zu Histidin) innerhalb der 310 Helix der C2A-Domäne von RIM wurde mit erhöhten kognitiven Fähigkeiten einer Patientengruppe in Verbindung gebracht. Weil die Drosophila C2A-Domäne eine hohe Homologie zur Säugerdomäne aufweist, konnte der Einfluss dieser Mutation auf Struktur und Funktion von Synapsen untersucht werden. Es zeigte sich, dass der Aminosäureaustausch der CORD7-Position und des benachbarten Arginin-Restes die synaptische Organisation und Transmission beeinflussen.
In einer Reihe weiterer Experimente wurde das Zusammenspiel von Bruchpilot und Synaptotagmin, dem Calciumsensor der evozierten Transmitterfreisetzung, analysiert. Während AZs ohne Bruchpilot auch ohne Synaptotagmin funktionieren, führt dessen Reduktion zu einer Umverteilung von Bruchpilot-Molekülen innerhalb von AZs und zu dramatischen Änderungen in ihrer Anzahl. Abschließend wurde so ein Beitrag zum Verständnis der molekularen Organisation synaptischer Informationsverarbeitung und Plastizität geleistet, wobei zu klären bleibt, wie die zuverlässige Speicherung von Informationen an AZs erreicht werden kann.
Ziel der Arbeit:
Der Einfluss langfristiger thyreosuppressiver Levothyroxintherapie auf den Schilddrüsenhormonmetabolismus bei Patienten mit differenziertem Schilddrüsenkarzinom ist bisher unbekannt. Ziel dieser Arbeit war es herauszufinden, ob und welche Änderungen der Schilddrüsenhormonparameter nach langfristiger LT4-Einnahme auftreten. Anhand der zweiten Studie sollte ermittelt werden, ob diese Veränderungen plötzlich und sprunghaft auftreten oder ob es sich dabei um einen kontinuierlichen Prozess handelt.
Patienten, Material, Methoden:
Das Kollektiv der ersten Studie bestand aus 61 Patienten mit differenziertem Schilddrüsenkarzinom. Für jeden dieser Patienten wurden eingefrorene Seren von zwei verschiedenen Zeitpunkten ausgewählt: Zeitpunkt 1 (entnommen in-nerhalb des ersten Jahres nach I-131-Ablation; TSH-Wert < 0,3 mlU/l; Rekrutie-rungszeitraum 1999-2002) und Zeitpunkt 2 (letzte verfügbare Probe mit TSH-Wert < 0,3 mIU/l; mindestens drei Jahre lang protokollierte, ununterbrochene LT4-Therapie; Rekrutierungszeitraum 2005-2009). Die Hormonspiegel von TSH, reversem T3, TT3 und TT4 und weiterer Parameter wurden zum Zeitpunkt 1 und Zeitpunkt 2 gemessen und die Beziehung dieser Parameter zueinander wurde analysiert.
In der zweiten Studie bildeten 24 Patienten mit differenziertem Schilddrüsen-karzinom das Patientenkollektiv. Auch hier wurden gefroren gelagerte Blutpro-ben nach bestimmten Kriterien ausgewählt und untersucht. Eingeschlossen wurden Patienten, von denen mindesten drei Seren im Anschluss an die letzte Hypothyreose vorhanden waren, die unter thyreosuppressiver Therapie ent-nommen wurden, so dass eine serielle Messung durchgeführt werden konnte. Der Zeitraum zwischen Hypothyreose und nachfolgendem Entnahmezeitpunkt des ersten folgenden Serums dufte höchsten neun Monate betragen. Die mediane Anzahl der vorhandenen Proben lag bei sechs, die mediane vergangene Zeit nach letzter Hypothyreose betrug 1,17 Jahre. Es wurde der zeitliche Verlauf der bestimmten Hormonparameter analysiert.
Ergebnisse:
Die Ergebnisse der ersten Studie zeigten signifikant erniedrigte TT3-, TT4- und TSH-Spiegel zum Zeitpunkt 2 (P < 0,001), während LT4-Dosis, Körpergewicht und rT3-Spiegel zwischen Zeitpunkt 1 und Zeitpunkt 2 konstant blieben. Es zeigten sich keine signifikanten Veränderungen in dem Verhältnis der LT4-Dosis pro kg Körpergewicht zu den fT4-Spiegeln (P = 0,83). Das Verhältnis von TT4 zu TT3 war zum Zeitpunkt 2 erhöht (P < 0,001), während das Verhältnis von TT4 zu rT3 und das Verhältnis von TT3 zu rT3 zum Zeitpunkt 2 signifikant erniedrigt waren.
Im kurzen Beobachtungszeitraum der zweiten Studie zeigten sich innerhalb der ersten 1,35 Jahre, in denen der durchschnittliche Entnahmezeitpunkt der Proben lag, keine wesentlichen Veränderungen bezüglich der LT4-Dosis pro kg Körpergewicht, der fT4-Spiegel, der rT3 Spiegel, des Verhältnisses von TT4 zu rT3 oder des Verhältnisses von TT4 zu TT3.
Fazit:
Es lässt sich schlussfolgern, dass nach langfristiger TSH-suppressiver Levothyroxintherapie bei Patienten mit differenziertem Schilddrüsenkarzinom signifikante Veränderungen im Schilddrüsenhormonmetabolismus auftreten, die am besten durch eine kombinierte Herunterregulierung der Typ-I-und der Typ-II-Deiodinase und einer Hochregulierung der Typ-III-Deiodinase zu erklären sind. Diese Veränderungen treten nicht plötzlich und sprunghaft auf sondern ereignen sich eher in einem kontinuierlichen Prozess über viele Jahre hinweg.