Refine
Has Fulltext
- yes (372)
Is part of the Bibliography
- yes (372)
Year of publication
Document Type
- Journal article (243)
- Doctoral Thesis (113)
- Preprint (14)
- Book article / Book chapter (1)
- Report (1)
Language
- English (372) (remove)
Keywords
- Organische Chemie (68)
- Supramolekulare Chemie (21)
- Selbstorganisation (18)
- self-assembly (17)
- fluorescence (14)
- Farbstoff (13)
- perylene bisimide (13)
- water oxidation (12)
- Merocyanine (11)
- RNA (11)
- Fluoreszenz (10)
- Perylenbisimid (10)
- Perylenderivate (10)
- Aggregation (9)
- supramolecular chemistry (9)
- Chemie (8)
- Elektronentransfer (8)
- photocatalysis (8)
- SARS-CoV-2 (7)
- polycyclic aromatic hydrocarbons (7)
- Squaraine (6)
- catalysis (6)
- dyes (6)
- energy transfer (6)
- in vitro selection (6)
- organic chemistry (6)
- Chemische Synthese (5)
- Chromophor (5)
- Exziton (5)
- Katalyse (5)
- Nucleinsäuren (5)
- Self-assembly (5)
- dyes/pigments (5)
- liquid crystals (5)
- luminescence (5)
- DNA (4)
- Flüssigkristall (4)
- Ladungstransfer (4)
- Metallosupramolekulare Chemie (4)
- NMR-Spektroskopie (4)
- Naphthylisochinolinalkaloide (4)
- Perylenbisdicarboximide <Perylen-3,4:9,10-bis(dicarboximide)> (4)
- Perylene Bisimide (4)
- Polymere (4)
- Ruthenium complexes (4)
- Supramolekulare Struktur (4)
- Wasseroxidation (4)
- aggregation (4)
- boranes (4)
- chemistry (4)
- chirality (4)
- circular dichroism (4)
- exciton coupling (4)
- macrocycles (4)
- organic solar cells (4)
- photoinduced electron transfer (4)
- ruthenium complexes (4)
- sphingolipids (4)
- structure elucidation (4)
- transient absorption (4)
- Aggregat <Chemie> (3)
- Ancistrocladaceae (3)
- C-C coupling (3)
- Chirality (3)
- Chiralität <Chemie> (3)
- DNS (3)
- Deoxyribozymes (3)
- Energietransfer (3)
- Fluorescence (3)
- Fotokatalyse (3)
- Hydrogel (3)
- Merocyanin (3)
- Quantenchemie (3)
- RNA modification (3)
- Ruthenium Komplexe (3)
- Selbstassemblierung (3)
- Self-Assembly (3)
- Triarylamine (3)
- Wasser (3)
- X-ray crystallography (3)
- absolute configuration (3)
- aromaticity (3)
- artificial photosynthesis (3)
- cell imaging (3)
- ceramide (3)
- ceramides (3)
- deoxyribozymes (3)
- electron transfer (3)
- homogeneous catalysis (3)
- kinetics (3)
- merocyanines (3)
- metallosupramolecular chemistry (3)
- molecular docking (3)
- naphthylisoquinoline alkaloids (3)
- non-covalent interactions (3)
- organic photodiodes (3)
- organische Solarzelle (3)
- pentacene (3)
- spectroscopy (3)
- transient absorption spectroscopy (3)
- triarylamine (3)
- 10-bis(dicarboximide)> (2)
- 4:9 (2)
- Ancistrocladus (2)
- Anorganische Chemie (2)
- Aptamer (2)
- Aromatically annulated triquinacenes (2)
- Aromatisch anellierte Triquinacene (2)
- Chili RNA Aptamer (2)
- Chiralität (2)
- Click-Chemie (2)
- Corannulene (2)
- Design (2)
- Dyade (2)
- Dyes (2)
- Energy Transfer (2)
- Epitranscriptomics (2)
- Exciton coupling (2)
- Exzitonenkopplung (2)
- FRET (2)
- Fluoreszenz-Resonanz-Energie-Transfer (2)
- G-quadruplexes (2)
- Gold (2)
- Guanidinderivate (2)
- Holothuria spinifera (2)
- J- and H-Aggregate (2)
- J- and H-Aggregates (2)
- J‐aggregates (2)
- LC-HRESIMS (2)
- Liquid Crystal (2)
- Merocyanine dyes (2)
- Methyltransferase (2)
- Molekulare Erkennung (2)
- Nucleoside (2)
- Oligomere (2)
- Organic Chemistry (2)
- Organische Solarzelle (2)
- Organische Synthese (2)
- Organischer Feldeffekttransistor (2)
- Organischer Halbleiter (2)
- Oxidation (2)
- Perylenbisdicarboximide (2)
- Perylenbisdicarboximide <Perylen-3 (2)
- Perylenbisimide (2)
- Perylene bisimide (2)
- Photochemistry (2)
- Photosensibilisator (2)
- Polycyclische Aromaten (2)
- Pyrene (2)
- RNA Enzymes (2)
- RNA labeling (2)
- RNA-dependent RNA polymerase (2)
- RNS (2)
- Ringöffnungspolymerisation (2)
- Rutheniumkomplexe (2)
- Scheibe-Aggregat (2)
- Selbstassoziation (2)
- Spinchemie (2)
- Strukturaufklärung (2)
- Supramolecular Chemistry (2)
- Transiente Absorption (2)
- Triarylamin (2)
- Triquinacenderivate (2)
- UV/Vis spectroscopy (2)
- Wasserstoffbrückenbindung (2)
- Wirt-Gast-Beziehung (2)
- XNA (2)
- absorption (2)
- acid sphingomyelinase (2)
- annulation (2)
- azulene (2)
- boron (2)
- boronate esters (2)
- cage compounds (2)
- cerebrosides (2)
- charge separation (2)
- charge transfer (2)
- chirality transfer (2)
- click chemistry (2)
- complexation (2)
- cooperativity (2)
- corannulene (2)
- covalent organic frameworks (2)
- crystal engineering (2)
- curved hydrocarbons (2)
- cyclophane (2)
- cyclophanes (2)
- cytotoxic activity (2)
- cytotoxicity (2)
- density functional calculations (2)
- diketopyrrolopyrroles (2)
- dimer (2)
- dynamic covalent chemistry (2)
- electrocatalysis (2)
- epitranscriptomics (2)
- fullerenes (2)
- gekrümmte Kohlenwasserstoffe (2)
- helicenes (2)
- heterogeneous catalysis (2)
- homogenous catalysis (2)
- hydrocarbons (2)
- hydrogen bonding (2)
- intervalence charge transfer (2)
- ligands (2)
- lysosome (2)
- macrocycle (2)
- marine natural product (2)
- mechanism (2)
- nanographene (2)
- naphthalene diimide (2)
- nicht-kovalente Wechselwirkungen (2)
- oligothiophenes (2)
- optical spectroscopy (2)
- organic semiconductors (2)
- organic solar cell (2)
- perylene bisimides (2)
- perylene dyes (2)
- phosphorescence (2)
- polymer-peptide-conjugate (2)
- polymerization (2)
- polymers (2)
- porphyrins (2)
- redox cascade (2)
- renewable fuels (2)
- ribozymes (2)
- ruthenium (2)
- ruthenium bda complexes (2)
- self-sorting (2)
- singlet oxygen (2)
- site-specific RNA cleavage (2)
- solid-state emitters (2)
- solvent effects (2)
- spin chemistry (2)
- squaraine dyes (2)
- stereochemistry (2)
- streptomyces (2)
- supramolecular polymers (2)
- supramolekulare Chemie (2)
- thermodynamics (2)
- thiol-ene (2)
- triplet (2)
- triquinacene derivatives (2)
- two-photon absorption (2)
- two-photon excited fluorescence (2)
- water (2)
- water splitting (2)
- "steepest descent-modest ascent" (1)
- "steilsten Abstieg - schwächste Aufstieg" (1)
- (bi)pyridine-based ligand (1)
- 2"-> (1)
- 2':6' (1)
- 2-photon absorption (1)
- 5'-O-Methyldioncophylline D (1)
- A-D-A dyes (1)
- A. abbreviatus (1)
- A. likoko (1)
- ADME analysis (1)
- AIE (1)
- API (1)
- Absolute Configuration (1)
- Absolute Konfiguration (1)
- Absorption (1)
- Acenes (1)
- Acetylneuraminsäure <N-> (1)
- Actinomyceten (1)
- Actinomycetes (1)
- Adsorption (1)
- Aggregate (1)
- Akzeptor <Chemie> (1)
- Aldehyde Bioconjugation (1)
- Alkaloid (1)
- Alkaloide (1)
- Alkoxylradikale (1)
- Alkoxylradikals (1)
- Alkyltransferase Ribozyme SAMURI (1)
- Alzheimer′s disease (1)
- Aminosäuren (1)
- Amphiphile Verbindungen (1)
- Amplification (1)
- Analysis of RNA Modifications (1)
- Anchimeric assistance in solvolysis (1)
- Ancistrocladus ealaensis (1)
- Ancistrocladus likoko (1)
- Ancistrolikokine E3 (1)
- Anode (1)
- Anti-infectious activity (1)
- Antiausterity activity (1)
- Antimalariamittel (1)
- Antimicrobial activities (1)
- Antimicrobial proteins (1)
- Antimikrobielle Aktivitäten (1)
- Antimikrobieller Wirkstoff (1)
- Antitumor-Antibiotikum (1)
- Antitumor-antibitioc (1)
- Antiviral nucleoside analogues (1)
- Apoptosis (1)
- Arene-Fluoroarene (1)
- Aromatic-hydrocarbon (1)
- Artificial Base Pair (1)
- Aspergillus niger (1)
- Asymmetric synthesis (1)
- Asymmetrische Synthese (1)
- Atomic and molecular interactions with photons (1)
- Atropisomere (1)
- Atropisomerie (1)
- BMP-2 (1)
- BMP-2 delivery (1)
- Bacillus megaterium (1)
- Baltic Sea (1)
- Barbituric Acid Merocyanines (1)
- Base pairing (1)
- Basenpaarung (1)
- Bicyclo[1.1.0]butylcarbinyl sulfonates (1)
- Biochemistry (1)
- Biocompatibility (1)
- Biodegradable polymer scaffolds (1)
- Biomaterial (1)
- Bioorganic chemistry (1)
- Bioorganik (1)
- Bioorthogonal (1)
- Bioorthogonal Tag (1)
- Biradikal (1)
- Bodipy (1)
- Bola-Amphiphil (1)
- Bone morphogenetic protein-2 (1)
- Bone tissue engineering (1)
- Bor-Stickstoff-Verbindungen (1)
- Borane (1)
- Boron-Nitrogen Dative Bond (1)
- Butadien (1)
- C-13 NMR (1)
- CCL2 (MCP-1) (1)
- CD-Spektroskopie (1)
- CD4+ T cells (1)
- CD8+ T cells (1)
- COVID-19 (1)
- CXCL8 (IL-8) (1)
- Caco-2 (1)
- Cage (1)
- Calix[4]aren (1)
- Carbazolderivate (1)
- Carbon (1)
- Carboxylat-Rezeptor (1)
- Catalysis (1)
- Ceramide (1)
- Charge-transfer-Komplexe (1)
- Chemical modification (1)
- Chemische Bindung (1)
- Chemische Reaktion (1)
- Chemosensor (1)
- Chirality Transfer (1)
- Chlorin (1)
- Chlorinderivate (1)
- Chromophore (1)
- Chromophore Assembly (1)
- Chromophores (1)
- Circular Dichroism (1)
- Circular dichroism (1)
- Circular-Dichroismus (1)
- Co-Crystal Structures of Chili RNA (1)
- Computational chemistry (1)
- Computerchemie (1)
- Congo (1)
- Congolese Ancistrocladus plants (1)
- Conjugated polymers (1)
- Coordination Polymer (1)
- Coronaviren (1)
- Covalent Organic Framework (1)
- Crosslinker (1)
- Crosslinking (1)
- Cryoelectron Microscopy (1)
- Cryoelectron microscopy (1)
- Crystal structure of MTR1 (1)
- Cyaninfarbstoff (1)
- Cyclic peptides (1)
- Cyclobutylcarbinyl sulfonates (1)
- Cyclooctine (1)
- Cyclooctyne (1)
- Cyclophan (1)
- Cyclovoltammetrie (1)
- DNA catalysis (1)
- DNA catalyst (1)
- DNA-based nanostructures (1)
- DNA-processing enzymes (1)
- DNA/RNA binding (1)
- DNA/RNA sensors (1)
- DNS-Schädigung (1)
- DOSY-NMR (1)
- Demethylase (1)
- Demethylierung (1)
- Demokratische Republik Kongo (1)
- Deoxyribozyme (1)
- Diamant (1)
- Diarylethen (1)
- Diarylethene (1)
- Diarylethylene (1)
- Dicarboximide (1)
- Dicarboximides (1)
- Dichtebestimmung in Theorie und Experiment (1)
- Dictyota (1)
- Dictyotaceae (1)
- Dihydrooxazole (1)
- Dimer (1)
- Dimer-Konfiguration (1)
- Dimere (1)
- Dimeric Naphthylisoquinoline Alkaloids (1)
- Dimers (1)
- Dioncophylline C (1)
- Donator <Chemie> (1)
- Donor (1)
- Donor-Akzeptor Triaden (1)
- Donor-Photosensibilisator-Akzeptor Triade (1)
- Donor−acceptor dyads (1)
- Drug Delivery System (1)
- Dyad (1)
- Dye (1)
- Dyes/pigments (1)
- Dünnschichttransistor (1)
- EPR (1)
- EPR spectroscopy (1)
- Effectors in plant pathology (1)
- Electron (1)
- Electron Transfer (1)
- Electron demand in ditosylates (1)
- Electron density (1)
- Electron transfer (1)
- Elektrochemie (1)
- Elektronendichte (1)
- Elektronendichtebestimmung (1)
- Elektronenspinresonanzspektroskopie (1)
- Emission (1)
- Energieaufnahme (1)
- Energietransfer <Mikrophysik> (1)
- Energy transfer (1)
- Enzym (1)
- Enzymes (1)
- Enzyminhibitor (1)
- Epitranskriptom (1)
- Eriodictyon californicum (1)
- Excitons (1)
- FT-IR spectroscopy (1)
- Farbstoffe (1)
- Farbstoffe/Pigmente (1)
- Festkörper-NMR (1)
- Festphasensynthese (1)
- Fiels-effect transistors (1)
- Fluorescence and Crosslinking (1)
- Fluoreszenzaktivierung (1)
- Fluoreszenzresonanz-Energietransfer (1)
- Fluoreszenzspektrometer (1)
- Fluoreszenzspektroskopie (1)
- Fluorogenic RNA Aptamers (1)
- Foldamers (1)
- Fulleren-Netzwerk (1)
- Fullerene (1)
- Functional nucleic acids (1)
- Functionalization (1)
- Fungal host response (1)
- Funktionalisierung <Chemie> (1)
- Funktionelle Polymere (1)
- Galectine (1)
- Garcinia biflavonoids (1)
- Gelieren (1)
- Gibbs activation energy (1)
- Glucosyltransferasen (1)
- Glycoengineering (1)
- Glycosyltransferase (1)
- Gold Nanoparticles (1)
- Gold Nanopartikel (1)
- Golgi (1)
- Graphene nanoribbons (1)
- Growth; BMP-2 (1)
- Grün fluoreszierendes Protein (1)
- Guanidiniocarbonylpyrrol (1)
- H-Aggregate (1)
- H-bonds (1)
- H2A histone family member X (H2AX) (1)
- HIV (1)
- HRMS (1)
- Halbleiter (1)
- Hekate (1)
- Helicene (1)
- Helicene diimide (1)
- Helicität <Chemie> (1)
- Helix- and Zick-Zack-Konformere (1)
- Helix- and Zig-Zag-Conformers (1)
- Helix-Coil-Transition (1)
- Helix-Knäuel-Umwandlung (1)
- Heterosolarzelle (1)
- Hexaarylbenzene (1)
- Hexaarylbenzole (1)
- High efficiency (1)
- High performance (1)
- High-Throughput Sequencing Method, DZ-seq (1)
- Higher-order Transient Absorption Spectroscopy (1)
- Host-Guest Chemistry (1)
- Host-Guest-Chemistry (1)
- Hydrogen bond (1)
- Hyperfine coupling constants (1)
- In-vitro (1)
- Indirect and direct contributions to A<sub>iso</sub> (1)
- Influence of excitation classes (1)
- Inhibitor (1)
- Intensity (1)
- Intermolecular Interactions (1)
- Intermolekulare Wechselwirkungen (1)
- Intervalenzladungstransfer (1)
- Iridium-Photosensibilisator (1)
- Iridiumkomplexe (1)
- Isolation (1)
- Isolierung (1)
- Isolierung <Chemie> (1)
- Isomorphe Nukleobasen-Analoga (1)
- J-Aggregat (1)
- J-Aggregate (1)
- J-Aggregates (1)
- J-aggregate (1)
- J-aggregate behavior (1)
- J-aggregates (1)
- Jozimine A2 (1)
- Jurkat cells (1)
- K-region (1)
- K2–K model (1)
- Kinetic Self-assembly (1)
- Kinetik (1)
- Kohlenhydrate (1)
- Kohlenstoff (1)
- Kohn-Sham Orbitale (1)
- Kohn-Sham Orbitals (1)
- Kolloidalstabilität (1)
- Kombinatorische Synthese (1)
- Komplexierung (1)
- Konfiguration <Chemie> (1)
- Konformeren (1)
- Konglomerat (1)
- Kongo (1)
- Kooperativität (1)
- Koordinationspolymer (1)
- Koordinationspolymere (1)
- Kraftfeld (1)
- Kupplungsreaktion (1)
- Käfigverbindungen (1)
- Ladungstrennung (1)
- Lebende Polymerisation (1)
- Lectins (1)
- Leitfähige Polymere (1)
- Lichtabsorption (1)
- Lichtsammelsystem (1)
- Ligand (1)
- Light-emitting diodes (1)
- Lippert–Mataga plot (1)
- Liquid Crystals (1)
- Liquid-crystalline (1)
- Living Polymerisation (1)
- Lower Critical Solution Temperature (LCST) (1)
- MAS (1)
- METTL8 (1)
- MRCI (1)
- Magnetfeldeffekt (1)
- Makrocyclische Verbindungen (1)
- Makrozyklus (1)
- Mandibular continuity defects (1)
- Marcus inverted region (1)
- Marrow stromal cells (1)
- Mechanismus (1)
- Merocyanine dye (1)
- Mesenchymal transition (1)
- Mesogen (1)
- Metabolismus (1)
- Metaheuristik-Suchmethoden (1)
- Metall-Ion (1)
- Metallosupramolecular chemistry (1)
- Methylierung (1)
- Methyltransferase Ribozyme (1)
- Methyltransferase Ribozyme MTR1 (1)
- Michael addition (1)
- Michael-Addition (1)
- Microenvironment (1)
- Mitochondrial Matrix Protein (1)
- Modified Nucleotides in tRNAs (1)
- Molecular dynamics (1)
- Molecular mechanism (1)
- Molecular probes (1)
- Molecular-dynamics (1)
- Molecules (1)
- Molekül (1)
- Moleküldynamik (1)
- Moleküloptimierung (1)
- Moller-Plesset (1)
- Molnupiravir (1)
- Molnupiravir-Induced RNA Mutagenesis Mechanism (1)
- Monoschicht (1)
- Mulliken-Hush (1)
- Multi Reference (1)
- Multibranched structures (1)
- Multireferenz (1)
- N-acetyllactosamine (1)
- N-oleoyl serinol (1)
- N6-methyladenosine (1)
- N6-methyladenosine (m6A) (1)
- NDI-H (1)
- NIQs (1)
- NIR OLED (1)
- NIR chromophore (1)
- NMR spectroscopy (1)
- Nanodiamant (1)
- Nanopartikel (1)
- Nanoribbon (1)
- Nanosegregation (1)
- Nanostructure (1)
- Nanostrukturen (1)
- Naphthalinbisimid (1)
- Naphthochinonen (1)
- Naphthoquinones (1)
- Naphthyl Isoquinolines (1)
- Naphthylisochinoline (1)
- Naphthylisoindolinone alkaloids (1)
- Naphthylisoquinolin (1)
- Naphthylisoquinoline (1)
- Naphthylisoquinoline alkaloids (1)
- Natural Products (1)
- Natural products (1)
- Naturstoffe (1)
- Neisseria (1)
- Nicht-Fulleren Akzeptor (1)
- Non-Fullerene Acceptor (1)
- Non-linear optics (1)
- Nonlinear Optical Properties of Organic Materials (1)
- Nucleic Acids (1)
- Nucleic acids (1)
- Nucleobase Analogue (1)
- Nucleobase Surrogate Incorporation (1)
- Nucleosidanaloga (1)
- Nukleinsäure (1)
- OEG chains (1)
- OFETs (1)
- OLC (1)
- OLED (1)
- Octavalen (1)
- Oligofructoside (1)
- Oligomers and Polymers (1)
- Oligonucleotide (1)
- Onbead-Enzymscreening (1)
- One-photon (1)
- Optical Spectroscopy (1)
- Optical properties (1)
- Optical spectroscopy (1)
- Optimierungsmethoden (1)
- Optimization methods (1)
- Oral squamous cell carcinoma (1)
- Organelles (1)
- Organic Field-Effect Transistor (1)
- Organic field-effect transistor (1)
- Organic semiconductors (1)
- Organische Halbleiter (1)
- PBI cyclophane (1)
- PEDOT (1)
- PI stacking (1)
- PNA (1)
- Pancreatic cancer (1)
- Paracyclophane (1)
- Pathway (1)
- Pentacen (1)
- Peptid-Nucleinsäuren (1)
- Peptidsynthese (1)
- Perovskite (1)
- Perylen-Farbstoffe (1)
- Perylenbisanhydrid (1)
- Perylenbisimiden (1)
- Perylenbisimides (1)
- Perylene Bisimides (1)
- Perylentetracarbonsäurederivate (1)
- Pflanzenzelle (1)
- Pflanzenzellkulturen (1)
- Phaeophyceae (1)
- Phosphoramidite (1)
- Phosphorylase (1)
- Photochemie (1)
- Photochromie (1)
- Photoconductivity (1)
- Photoelektron (1)
- Photoresponsive DNA Crosslinker (1)
- Phytochemical investigations of a Congolese Ancistrocladus Liana (1)
- Phytochemie (1)
- Plant cell cultures (1)
- Polyamin (1)
- Polycarbazole (1)
- Polycyclic aromatic hydrocarbons (1)
- Polymer (1)
- Polymer-drug interaction (1)
- Polymerhalbleiter (1)
- Polymerkomplexe (1)
- Polymerlösung (1)
- Polymers (1)
- Polymorphismus (1)
- Porosität (1)
- Porous Materials (1)
- Porphyrin (1)
- Potential-energy curves (1)
- Protease (1)
- Protein Corona (1)
- Proteinadsorption (1)
- Proteinen mit antimikrobieller Wirkung (1)
- Protonen-NMR-Spektroskopie (1)
- Protonenreduktion (1)
- Pyren (1)
- Pyrenderivate (1)
- QM/MM (1)
- Quadruplex-DNS (1)
- Quality assessment of antimalarial medicines from the Congo (1)
- Quantenchemische Rechnungen (1)
- Quantifizierung (1)
- Quantum Chemical CD Calculations (1)
- Quantum Chemical Calculations (1)
- Quantum mechanics / molecular modeling (1)
- Quasi-Newton-Verfahren (1)
- RAFT (1)
- RNA Aptamer (1)
- RNA G-quadruplex (1)
- RNA Labelling (1)
- RNA Methyltransferase (1)
- RNA Modification (1)
- RNA aptamers (1)
- RNA cleavage (1)
- RNA ligation (1)
- RNA modifications (1)
- RNA splicing (1)
- RNA structures (1)
- RNA-Aptamere (1)
- RNA-Cleaving Deoxyribozymes (1)
- RNA-Dependent RNA Polymerase (1)
- RNA-catalyzed RNA methylation (1)
- RU-(II) complexes (1)
- Radical-ion pair (1)
- Raman (1)
- Raumfüllung (1)
- Rearrangement of carbocations (1)
- Redox-Kaskade (1)
- Redoxkaskade (1)
- Redoxreaktion (1)
- Reduction (1)
- Remdesivir (1)
- Reticular Chemistry (1)
- Ribozym (1)
- Ribozyme (1)
- Ribozyme-catalyzed RNA labeling (1)
- Ribozymes (1)
- Ring closing metathesis (1)
- Ringschlussmetathese (1)
- Rotation (1)
- Ru(II)–Fe(II)–Ru(II) complex (1)
- Ruthenium (1)
- Ruthenium-Photosensibilisator (1)
- Räumliche Anordnung (1)
- Röntgendiffraktometrie (1)
- SARS (1)
- SARS-CoV-2 polymerase (1)
- SARS-CoV2 Replication Impairment (1)
- SELEX (1)
- SERS (1)
- SIB (1)
- SacB (1)
- Scleractinia (1)
- Screening (1)
- Second coordination sphere engineering (1)
- Self-Assembly in Water (1)
- Self-Sortierung (1)
- Sialic acids (1)
- Sialinsäuren (1)
- Simulations (1)
- Single-molecule microscopy (1)
- Sinus floor augmentation (1)
- Site-Specific RNA Cleavage (1)
- Site-specific RNA labelling (1)
- Solid-State NMR Spectroscopy (1)
- Solution-state NMR (1)
- Sonogashira (1)
- Sonogashira-Hagihara-Reaktion (1)
- Space filling (1)
- Spectroscopy (1)
- Speicher <Informatik> (1)
- Spektroelektrochemie (1)
- Spermin (1)
- Spin density (1)
- Spin flip (1)
- Spin labels (1)
- Spin-Sonde (1)
- Spin-chemistry (1)
- Squamous-cell carcinoma (1)
- Squarain Farbstoffe (1)
- Squaraine Dyes (1)
- Sracking (1)
- Stacking (1)
- Staphylococcus aureus (1)
- State (1)
- Stereochemistry (1)
- Stokes-Verschiebung (1)
- Stokes-shifted fluorescence emission (1)
- Streptomyces axinellae (1)
- Structural Biology (1)
- Structural elucidation (1)
- Structure elucidation (1)
- Struktursonden (1)
- Stylissa carteri (1)
- Suc1 (1)
- Supercap (1)
- Superkondensator (1)
- Supramolecular Block Copolymers (1)
- Supramolecular Element (1)
- Supramolecular Interaction (1)
- Supramolecular aggregates (1)
- Supramolecular electronics (1)
- Supramolekulare Aggregate (1)
- Suzuki coupling (1)
- Synthese (1)
- Synthesediamant (1)
- Synthetic Functional RNAs (1)
- Synthetischer Farbstoff (1)
- Systems (1)
- TD-DFT (1)
- TERRA RNA (1)
- Tabusuche (1)
- Targeting (1)
- Taxol (1)
- Terpyridinderivate <2 (1)
- Terrylenbisimid (1)
- Terrylenderivate (1)
- Terrylene bisimide (1)
- Thalassodendron ciliatum (1)
- Theoretical Chemistry (1)
- Theoretische Charakterisierung (1)
- Theoretische Chemie (1)
- Theorie (1)
- Thermodynamics (1)
- Thiophen (1)
- Tiplet emiters (1)
- Tiplett Emitter (1)
- Tolane-Modified Fluorescent Nucleosides (1)
- Total Synthesis (1)
- Totalsynthese (1)
- Triad (1)
- Triplett (1)
- Tumorigenicity (1)
- Two-photon absorption (1)
- UV-VIS-Spektroskopie (1)
- UV/Vis-Absorption (1)
- Ultrafast spectroscopy (1)
- Vergleich (1)
- Vesikel (1)
- Vibronic contributions (1)
- Wasserlösliche Polymere (1)
- Wasseroxidationsreaktion (1)
- Wasserspaltung (1)
- Wasserstoffbrücken (1)
- Water (1)
- Water Oxidation (1)
- Wirkmechanismus (1)
- Wirkstoff-Träger-System (1)
- Wirt-Gast-Komplex-Chemie (1)
- X-Ray Diffraction (1)
- X-ray Crystallography (1)
- X-ray diffraction (1)
- XRPD (1)
- Xanthin (1)
- YTH reader proteins (1)
- Zelladhäsion (1)
- Zellkultur (1)
- Zinc Chlorin (1)
- Zink (1)
- Zinkchlorine (1)
- Zweidimensionale NMR-Spektroskopie (1)
- Zweiphotonenabsorption (1)
- [FeFe] hydrogenase mimic (1)
- [FeFe]-Hydrogenase Imitator (1)
- [n]helicenes (1)
- \(\alpha\)-phase (1)
- \(\beta\)-phase (1)
- \(^{1}\)H-\(^{13}\)C HETCOR (1)
- abietane (1)
- acceptor (1)
- activating transcription factor 4 (ATF4) (1)
- adsorption (1)
- aelf-assembly (1)
- alkaloids (1)
- alkaloids-Quinoid (1)
- alkene-alkyne [2+2] photocycloaddition (1)
- amodiaquine (1)
- amphiphilic dyes (1)
- amplification (1)
- ancistrocladinium A (1)
- angeregte Zustände (1)
- annihilation (1)
- anti-cancer-agent (1)
- anti-depressant drug (1)
- anti-trypanosomal (1)
- antibacterial activity (1)
- antidepressants (1)
- antimicrobials (1)
- aqua material (1)
- aqueous medium (1)
- arene-fluoroarene (1)
- arenes (1)
- aromatic compounds (1)
- artemether - lumefantrine (1)
- artificial base pair (1)
- association (1)
- ataxia teleagiectasia mutated (ATM) (1)
- atomic mutagenesis (1)
- atropisomer (1)
- azaborole (1)
- azaphilone (1)
- azido-ceramides (1)
- bacterial infection (1)
- bartalinia robillardoides (1)
- biflavanoids (1)
- bile salt (1)
- bioactive compound (1)
- bioactivities (1)
- biocatalysis (1)
- biocompatibility (1)
- biological techniques (1)
- biomass (1)
- bioorthogonal SAM analogue ProSeDMA (1)
- bioorthogonal metabolic glycoengineering; click chemistry; sialic acid (1)
- biophysical investigation (1)
- biosynthesis (1)
- biradical (1)
- bis-terpyridyl ligands (1)
- bola-amphiphile (1)
- boric acid (1)
- boronateesters (1)
- borylation (1)
- brown seaweeds (1)
- bulk-heterojunction solar cells (1)
- calix[4]arene (1)
- capillary zone electrophoresis (1)
- carbohydrate chemistry (1)
- carbon (1)
- carboxylate receptor (1)
- carrier transport (1)
- cascade reactions (1)
- catalyst (1)
- catalyst synthesis (1)
- catalysts (1)
- catalytic (1)
- catalytic DNA (1)
- catalytic activity (1)
- catalytic mechanisms (1)
- cell membrane model (1)
- cellular stress response (1)
- ceramidase (1)
- ceramide analogs (1)
- cerebroside (1)
- ceriops decandra (1)
- charge recombination (1)
- charge transport (1)
- charge transport; hydrogen bonding; oligothiophene; organogel; self-assembly (1)
- charge-separated state (1)
- chemical modification (1)
- chiral resolution (1)
- chlorin (1)
- circular polarized luminescence (1)
- circularly polarized luminescence (1)
- co-aggregation (1)
- cocrystallization (1)
- colloid (1)
- columnar phases (1)
- complexity (1)
- computational chemistry (1)
- configurational stability (1)
- conformational search (1)
- conjugated molecule (1)
- conjugation (1)
- cooperative (1)
- cooperative self-assembly (1)
- coordination chemistry (1)
- coordination isomerism (1)
- coordination oligomer (1)
- coordination oligomers (1)
- coordination polymer (1)
- covalent and site-specific RNA labeling (1)
- covalent organic framework (1)
- cristal engeneering (1)
- crystalline (1)
- crystals (1)
- curcumin (1)
- curvature (1)
- curved π-systems (1)
- cyclic perylene bisimide (1)
- cyclic trimer (1)
- cyclic voltammetry (1)
- cyclische Trimere (1)
- cyclodehydrogenation (1)
- cylindrical micelles (1)
- cysteine protease (1)
- cytoplasm (1)
- decandrinin (1)
- demethylase enzymes FTO and ALKBH5 (1)
- deracemization (1)
- di-\(\pi\)-methane rearrangement (1)
- diamond (1)
- dibenzosemibullvalenes (1)
- dicarboximide (1)
- differential scanning calorimetry (1)
- diffusion (1)
- dimerer Naphthylisochinolin-Alkaloide (1)
- dimerization (1)
- dimers (1)
- dinuclear (1)
- dipolar aggregation (1)
- dipole-dipole interaction (1)
- discotic liquid crystals (1)
- discovery (1)
- dissolution rates (1)
- disulfide bonds (1)
- docking (1)
- docking studies (1)
- domain shift (1)
- donor-acceptor dyad (1)
- donor-acceptor dyads (1)
- donor-acceptor interactions (1)
- donor-acceptor triads (1)
- donor-photosensibilisator-acceptor triad (1)
- donor–acceptor (1)
- donor–acceptor dyads (1)
- drug delivery (1)
- drugs (1)
- duplex structure (1)
- dyad (1)
- dyads (1)
- dye (1)
- dye assembly (1)
- dye chemistry (1)
- electrodes (1)
- electron density (1)
- electronic and spintronic devices (1)
- electronic collective variables (1)
- electronic devices (1)
- electronic structure (1)
- electronic wavefunction (1)
- emission (1)
- enantiomerization (1)
- enantiomers (1)
- encapsulation (1)
- energy transfer dynamics (1)
- enzyme (1)
- enzyme engineering (1)
- enzyme purification (1)
- enzyme structure (1)
- enzymes (1)
- ergosterol derivative (1)
- ethenoanthracenes (1)
- excimer (1)
- excimer formation (1)
- excited states (1)
- exciton dynamics (1)
- excitonic chirality (1)
- experimental and theoretical determination of electron density (1)
- extractives (1)
- ferroelectrics (1)
- films (1)
- flavenoids (1)
- flavonoids (1)
- flourescence quantum yield (1)
- fluerescence (1)
- fluorenscence (1)
- fluorescence resonance energy transfer (1)
- fluorescence spectroscopy (1)
- fluorescent (1)
- fluorescent probes (1)
- fluorescent protein (1)
- fluorescent resonance energy transfer (1)
- fluorogen-activating RNA aptamer (FLAP) (1)
- fluoxetine (1)
- flux (1)
- folda-dimer (1)
- folded macrocyles (1)
- folding (1)
- folding landscapes (1)
- force field (1)
- fullerene network (1)
- functional dyes (1)
- functionalization (1)
- galectin-1 (1)
- global minimum (1)
- glycocalyx (1)
- glycosphingolipids (1)
- gold (1)
- growth (1)
- guanidiniocarbonyl pyrrole (1)
- guttiferae (1)
- hMSC-TERT (1)
- halbleitende Polymere (1)
- halichondria panicea (1)
- heavy metals (1)
- helicene (1)
- heterocycles (1)
- hexaarylbenzenes (1)
- hexakisadducts (1)
- high-temperature NMR (1)
- homochiral dimer (1)
- host-guest (1)
- host-guest chemistry (1)
- host-guest systems (1)
- hybrid materials (1)
- hydrazone (1)
- hydrogel (1)
- hydrogen bond (1)
- hydrogen peroxide (1)
- hydroxylation (1)
- imaging (1)
- imidization (1)
- imines (1)
- impurity profiling (1)
- in vitro Selection (1)
- in vitro selection from a structured RNA library (1)
- induced phase transition (1)
- inflammation (1)
- inherent chirality (1)
- inhibitor (1)
- intermolecular applications of ribozymes (1)
- intersystem crossing (1)
- intervalence charge-transfer (1)
- intrinsic free space (1)
- invasion (1)
- inflammatory response (1)
- ion pairing (1)
- iridium complex (1)
- iridium photosensitizer (1)
- iron oxide nanoparticles (1)
- isomorphic nucleobase analog (1)
- isotropic hyper fine coupling (1)
- key structure - fluorescence activation relationships (SFARs) (1)
- ladungsgetrennte Zustände (1)
- large Stokes shift (1)
- large stokes shift (1)
- laser (1)
- lectin (1)
- ligand binding (1)
- light harvesting (1)
- light-induced interstrand DNA crosslinking (1)
- liposome (1)
- liquid crystal alignment (1)
- liquid crystal (1)
- livingstonei (1)
- low-valent compounds (1)
- luminescent solar concentrators (1)
- magnetic field effect (1)
- major depression (1)
- marine bacteria (1)
- marine fungi (1)
- marine macroalgae (1)
- marine natural products (1)
- marine sponge (1)
- materials (1)
- materials design (1)
- measles (1)
- merocyanine (1)
- merocyanine dye (1)
- merocyanine dyes/pigments (1)
- mesogens (1)
- metabolic analysis (1)
- metabolic glycoengineering (1)
- metabolism (1)
- metadynamics (1)
- metaheuristic methods (1)
- metal complexenes (1)
- metal-ion-ligand coordination (1)
- metal-to-ligand charge transfer (MLCT) (1)
- metallomacrocycles (1)
- metallosupramolecular π-amphiphiles (1)
- methyl viologen (1)
- methyltransferase (1)
- micelles (1)
- microbiology (1)
- microbiology techniques (1)
- microscopy (1)
- microtubes (1)
- migration (1)
- minimal inhibitory concentration (1)
- mobility (1)
- mode of action (1)
- modified RNA nucleotides (1)
- modified monosaccharides (1)
- modified nucleosides (1)
- molecular (1)
- molecular capsules (1)
- molecular dynamics (1)
- molecular recognition (1)
- molecules (1)
- molekulare Erkennung (1)
- multichromophoric arrays (1)
- multiflora (1)
- multimetallic complexes (1)
- multiple myeloma (1)
- n-type semiconductors (1)
- nanomaterials (1)
- nanoparticles (1)
- nanorods and nanosheets (1)
- nanoscale imaging (1)
- nanosegregation (1)
- nanotube (1)
- naphthylisoquinoline alkaloid (1)
- narrow bandwidth (1)
- natural products (1)
- near infrared chirality (1)
- near infrared emitter (1)
- near-IR chromophores (1)
- near-infrared sensitivity (1)
- neutral polyradical (1)
- neutrales Polyradikal (1)
- non-fullerene acceptor (1)
- non-fullerene acceptors (1)
- noncovalent interactions (1)
- nonfullerene acceptors (1)
- nucleation elongation (1)
- nucleation-elongation (1)
- nucleation-elongation model (1)
- nucleic acid (1)
- nucleic acids (1)
- nucleoside modification recognition (1)
- null-aggregate (1)
- obstructive pulmonary disease (1)
- oligo(phenylene ethynylene) (OPE) (1)
- oligomers (1)
- oligothiophene (1)
- on surface self-assembly (1)
- onbead enzym screening (1)
- optical materials (1)
- optical properties (1)
- optics (1)
- optische Eigenschaften (1)
- organic semiconductors (1)
- organic compounds (1)
- organic light emitting diodes (1)
- organic photovoltaics (1)
- organic semiconductor (1)
- organic transistor (1)
- organische Photovoltaik (1)
- organische Solarzellen (1)
- organischer Feldeffekttransistor (1)
- organischer Transitor (1)
- organization (1)
- organogelator (1)
- orylation (1)
- oxidation (1)
- oxygen reduction reaction (1)
- p-conjugated systems (1)
- pancreatic cancer (1)
- parallel polar dimers (1)
- pentaketide (1)
- peptide backbone (1)
- perylene (1)
- perylene bisimide dimers (1)
- perylene bisimide dyes (1)
- perylene bisimide hydrogels (1)
- perylene bismide dye (1)
- perylene imide (1)
- perylenebisimide (1)
- perylenebisimide dyes (1)
- phenazine (1)
- phenylboronate (1)
- phosphodiesterase-4 inhibitor (1)
- photochemical (1)
- photoconductive interlayer (1)
- photoinduzierter Elektronentransfer (1)
- photoluminescence (1)
- photophysics (1)
- photoresponsive behavior (1)
- photosenitizers (1)
- photosensitization (1)
- phthalocyanines (1)
- pi-pi Wechselwirkungen (1)
- pi-pi- stacking (1)
- platinum complexes (1)
- pol(2-oxazoline) (1)
- polar solution (1)
- polare Lösung (1)
- polarizing optical microscopy (1)
- poly(2-oxazine) (1)
- poly(2-oxazoline)s (1)
- polyamine (1)
- polycarbazole (1)
- polycycles (1)
- polycyclic aromatic hydrocarbon (1)
- polyglycidol (1)
- polymer drug interaction (1)
- polymorphism (1)
- polyoxazolines (1)
- polypyridyl complexes (1)
- porous materials (1)
- porousmaterials (1)
- position-specific installation of m1A in RNA (1)
- probes (1)
- protease (1)
- protease inhibition (1)
- proteasome inhibitor resistance (1)
- proteasome subunit beta type-5 (PSMB5) (1)
- protein adsorption (1)
- protein crystallography (1)
- protein-ligand-interaction (1)
- proton reduction (1)
- push–pull thienylthiazole (1)
- pyrene (1)
- quantenchemische Berechnungen (1)
- quantum chemical analysis (1)
- quantum optics (1)
- quaterrylene bisimide (1)
- quercetin (1)
- rBAM2-labeled RNA strands (1)
- racemization (1)
- radical (1)
- radical anion (1)
- radical ion pair (1)
- reabsorption (1)
- real-time NMR spectroscopy (1)
- recombinant proteins (1)
- redox (1)
- regulatory T cells (1)
- regulatory T cells (Treg) (1)
- renew-able fuels (1)
- resveratrol (1)
- rhizophoraceae (1)
- rigidification (1)
- ring opening polymerisation (1)
- ring-opening polymerization (1)
- rofumilast (1)
- room-temperature phosphorescence (RTP) (1)
- rotation (1)
- rotational diffusion (1)
- ruthenium catalysts (1)
- ruthenium photosensitizer (1)
- sSupramolecular interaction (1)
- scanning probe microscopy (1)
- seagrass (1)
- seco-NIQs-Naphthylisoindolinone (1)
- selbst organisierende Monolagen (SAM) (1)
- selbstaggregierten (1)
- self-assembled monolayer (SAM) (1)
- semiconducting polymers (1)
- separation techniques (1)
- shape-amphiphiles (1)
- short-range JCT-coupling (1)
- short-range order (1)
- sialic acids (1)
- simulated intestinal fluid (1)
- single crystal structure (1)
- site-specific RNA labeling (1)
- social self‐sorting (1)
- solar cells (1)
- solar fuels (1)
- solid-state NMR (1)
- solid-state NMR spectroscopy (1)
- solid-state emitter (1)
- solid‐state emission (1)
- solubility (1)
- solvatochromism (1)
- solvolysis of (1)
- spacer-controlled self-assembly (1)
- spectroscopic analysis (1)
- spermine (1)
- sphingolipid expansion microscopy (1)
- sphingomyelinase (1)
- sphingosine (1)
- sphingosine 1-phosphate (1)
- sphingosine kinases (1)
- spin relaxation (1)
- squaraine polymer (1)
- stability (1)
- star-shaped compounds (1)
- starazine (1)
- starphene analogue (1)
- stereospecific sythesis (1)
- sterubin (1)
- stokes shift (1)
- structural biology (1)
- structural changes (1)
- structural dynamics (1)
- structural elucidation (1)
- structural restriction (1)
- structure probes (1)
- structure probing (1)
- structure–function relation (1)
- structure–property relation (1)
- subphthalocyanine (1)
- substandard and falsified medicines from the Congo (1)
- sucrose phosphorylase (1)
- superparamagnetism (1)
- superstructure (1)
- supramolecular (1)
- supramolecular assembly (1)
- supramolecular folding (1)
- supramolecular materials (1)
- supramolecular polymerization (1)
- supramolekular (1)
- supramolekularen Elektronik (1)
- surface interactions (1)
- survival (1)
- sustainable energy source (1)
- swallow-tail (1)
- synthesis (1)
- systems (1)
- template catalysis (1)
- tenofovir (1)
- tethya aurantium (1)
- tetracoordinated boron (1)
- tetromycin (1)
- theoretical characterisation (1)
- theoretical investigations (1)
- theoretische Untersuchungen (1)
- theranostics (1)
- thin film transistor (1)
- thin-film transistors (1)
- time-resolved impulsive stimulated raman spectroscopy (1)
- tissue engineering (1)
- topological analysis (1)
- topologische Analyse (1)
- trans-acting 2'-5' adenylyl transferase ribozymes (1)
- transiente Absorption (1)
- transiente Absorptionsspektroskopie (1)
- triaryalmine (1)
- triarylborane (1)
- trinuclear (1)
- triplet sensitization (1)
- two-dimensional nanostructures (1)
- umbrella-shaped mesogens (1)
- upconversion (1)
- upramolecular polymerization process (1)
- vacuum processable (1)
- vesicle (1)
- vibrational coherence (1)
- viral epidemiology (1)
- viral infection (1)
- water oxidation catalysis (1)
- water oxidation reation (1)
- xanthine (1)
- zooxanthellae (1)
- zyklische Peptide (1)
- π-conjugated systems (1)
- π-extension (1)
- π-π-interactions (1)
- π–π Stacking (1)
Institute
- Institut für Organische Chemie (372) (remove)
Schriftenreihe
Sonstige beteiligte Institutionen
- International Max Planck Research School Molecular Biology, University of Göttingen, Germany (2)
- Agricultural Center, BASF SE, 67117 Limburgerhof, Germany (1)
- Center for Nanoscale Microscopy and Molecular Physiology of the Brain (CNMPB), Göttingen, Germany (1)
- Center for Nanosystems Chemistry (1)
- Center for Nanosystems Chemistry (CNC), University of Würzburg (1)
- Center for Nanosystems Chemistry (CNC), Universität Würzburg, Am Hubland, 97074 Würzburg, Germany (1)
- Charles University, Faculty of Mathematics and Physics, Ke Karlovu 5, 121 16 Prague, Czech Republic (1)
- Cluster of Excellence "Multiscale Bioimaging: from Molecular Machines to Networks of Excitable Cells, Göttingen (1)
- Department of Cellular Biochemistry, University Medical Center Göttingen (1)
- Department of Cellular Biochemistry, University Medical Centre Göttingen (1)
Reaktionen von 1,3-Butadien und einigen seiner Methylderivate mit 1a und 1- Methyl-1,2-cyclohexadien 1b sowie den Übergang der [2 + 2]-Cycloaddukte 2 und 3 in das bisher unbekannte 1,2,3,5,8,8a-HexahydronaphthaJin 4a und einige seiner Methylderivate
Herein we devise and execute a new synthesis of a pristine boron-doped nanographene. Our target boron-doped nanographene was designed based on DFT calculations to possess a low LUMO energy level and a narrow band gap derived from its precise geometry and B-doping arrangement. Our synthesis of this target, a doubly B-doped hexabenzopentacene (B\(_{2}\)-HBP), employs six net C−H borylations of an alkene, comprising consecutive hydroboration/electrophilic borylation/dehydrogenation and BBr\(_{3}\)/AlCl\(_{3}\)/2,6-dichloropyridine-mediated C−H borylation steps. As predicted by our calculations, B\(_{2}\)-HBP absorbs strongly in the visible region and emits in the NIR up to 1150 nm in o-dichlorobenzene solutions. Furthermore, B\(_{2}\)-HBP possesses a very low LUMO level, showing two reversible reductions at −1.00 V and −1.17 V vs. Fc\(^{+}\)/Fc. Our methodology is surprisingly selective despite its implementation of unfunctionalized precursors and offers a new approach to the synthesis of pristine B-doped polycyclic aromatic hydrocarbons.
The He (I) photoelectron spectra of 2-bicyclo[2.1.l]hexene (1), 2,3-bis(methylene)bicyclo[2.1.l]hexane (3), and 3,4-bis(methylene)tricyclo[3.l.O.0\(^{2.6}\)]hexane (4) have been investigated. The assignment given is based on a ZDO model and semiempirical calculations. Tagether with the PE data of benzvalene (2), the reported data allow a comparison between 1-2 and 3-4. This yields a measure of the interactions between 8 cyclobutane or 8 bicyclobutane moiety and a double bond system within a ZDO model. The resonance integral found in the case of 1 and 3 amounts to -1.9 eV, that for 2 and 4, to -2.3 eV. The investigations furthermore reveal that the electronic factors which contribute to the higher reactivity of the bicyclobutane compounds amount to 5 kcal/mol.
A Calix[4]arene‐Based Cyclic Dinuclear Ruthenium Complex for Light‐Driven Catalytic Water Oxidation
(2021)
A cyclic dinuclear ruthenium(bda) (bda: 2,2’‐bipyridine‐6,6’‐dicarboxylate) complex equipped with oligo(ethylene glycol)‐functionalized axial calix[4]arene ligands has been synthesized for homogenous catalytic water oxidation. This novel Ru(bda) macrocycle showed significantly increased catalytic activity in chemical and photocatalytic water oxidation compared to the archetype mononuclear reference [Ru(bda)(pic)\(_2\)]. Kinetic investigations, including kinetic isotope effect studies, disclosed a unimolecular water nucleophilic attack mechanism of this novel dinuclear water oxidation catalyst (WOC) under the involvement of the second coordination sphere. Photocatalytic water oxidation with this cyclic dinuclear Ru complex using [Ru(bpy)\(_3\)]Cl\(_2\) as a standard photosensitizer revealed a turnover frequency of 15.5 s\(^{−1}\) and a turnover number of 460. This so far highest photocatalytic performance reported for a Ru(bda) complex underlines the potential of this water‐soluble WOC for artificial photosynthesis.
A comparative ab initio study of the Si\(_2\)C\(_4\), Si\(_3\)C\(_3\), Si\(_4\)C\(_2\) clusters
(1994)
Various structural possibilities for the Si\(_2\)C\(_4\) and Si\(_4\)C\(_2\) clusters are investigated by employing a basis set of triple-zeta plus polarization quality; electron correlation is generally accounted for by second-order M0ller-Plesset and, in certain instances, by higher-order perturbation (CASPT2) approaches. The building-up principle recently suggested from an analysis of Si\(_3\)C\(_3\) clusters is found to be fully operative for Si\(_2\)C\(_4\) and Si\(_4\)C\(_2\) clusters. A comparison of the structure and stability of various geometrical arrangements in the series C\(_6\) , Si\(_2\)C\(_4\) , Si\(_3\)C\(_3\) , Si\(_4\)C\(_2\), and Si\(_6\) shows that linear and planar structures become rapidly less stable if carbons are replaced by silicons and that the three-dimensional bipyramidal forms become less favorable as soon as silicons are exchanged by carbons in the parent Si\(_6\) structure. The effects can be rationalized in qualitative terms based on differences in silicon and carbon bonding.
The future of water-derived hydrogen as the “sustainable energy source” straightaway bets on the success of the sluggish oxygen-generating half-reaction. The endeavor to emulate the natural photosystem II for efficient water oxidation has been extended across the spectrum of organic and inorganic combinations. However, the achievement has so far been restricted to homogeneous catalysts rather than their pristine heterogeneous forms. The poor structural understanding and control over the mechanistic pathway often impede the overall development. Herein, we have synthesized a highly crystalline covalent organic framework (COF) for chemical and photochemical water oxidation. The interpenetrated structure assures the catalyst stability, as the catalyst’s performance remains unaltered after several cycles. This COF exhibits the highest ever accomplished catalytic activity for such an organometallic crystalline solid-state material where the rate of oxygen evolution is as high as ∼26,000 μmol L\(^{–1}\) s\(^{–1}\) (second-order rate constant k ≈ 1650 μmol L s\(^{–1}\) g\(^{–2}\)). The catalyst also proves its exceptional activity (k ≈ 1600 μmol L s\(^{–1}\) g\(^{–2}\)) during light-driven water oxidation under very dilute conditions. The cooperative interaction between metal centers in the crystalline network offers 20–30-fold superior activity during chemical as well as photocatalytic water oxidation as compared to its amorphous polymeric counterpart.
This PhD thesis introduced several concepts for the construction of new supramolecular assem-blies in polar solvents. Although the building blocks differ in their binding mode and association strength they follow the same principle: one main driving force for the self-assembly in polar solutions in combination with one texturing force. The main self-assembly process is based on the mutual interaction of hydrogen-bond enforced ion pairs which deliver the association energy needed for stable, supramolecular structures even in polar solvents. The texturing force itself is represented by the linkers between the zwitterionic building blocks or parts of them. The different length and functionalization of the linkers have a tremendous influence on the mode of self-assembly leading to cyclic dimers, vesicles, layers or solid spheres. Hence, this principle is suitable for the construction of programmable monomers. Since the derivatisation of the main binding motive is rather simple it offers a great number of new and undoubtedly fascinating structures with potential applications in material and biomimetic science.
A new strategy is demonstrated for the synthesis of warped, negatively curved, all‐sp\(^2\)‐carbon π‐scaffolds. Multifold C−C coupling reactions are used to transform a polyaromatic borinic acid into a saddle‐shaped polyaromatic hydrocarbon (2 ) bearing two heptagonal rings. Notably, this Schwarzite substructure is synthesized in only two steps from an unfunctionalized alkene. A highly warped structure of 2 was revealed by X‐ray crystallographic studies and pronounced flexibility of this π‐scaffold was ascertained by experimental and computational studies. Compound 2 exhibits excellent solubility, visible range absorption and fluorescence, and readily undergoes two reversible one‐electron oxidations at mild potentials.
AbstractWater oxidation catalysis is a key step for sustainable fuel production by water splitting into hydrogen and oxygen. The synthesis of a novel coordination oligomer based on four Ru(bda) (bda = 2,2′‐bipyridine‐6,6′‐dicarboxylate) centers, three 4,4′‐bipyridine (4,4′‐bpy) linkers, and two 4‐picoline (4‐pic) end caps is reported. The monodispersity of this tetranuclear compound is characterized by NMR techniques. Heterogeneous electrochemical water oxidation after immobilization on multi‐walled carbon nanotubes (MWCNTs) shows catalytic performance unprecedented for this compound class, with a turnover frequency (TOF) of 133 s\(^{−1}\) and a turnover number (TON) of 4.89 × 10\(^6\), at a current density of 43.8 mA cm\(^{−2}\) and a potential of 1.45 V versus normal hydrogen electrode (NHE).
Large Stokes shift (LSS) fluorescent proteins (FPs) exploit excited state proton transfer pathways to enable fluorescence emission from the phenolate intermediate of their internal 4 hydroxybenzylidene imidazolone (HBI) chromophore. An RNA aptamer named Chili mimics LSS FPs by inducing highly Stokes-shifted emission from several new green and red HBI analogs that are non-fluorescent when free in solution. The ligands are bound by the RNA in their protonated phenol form and feature a cationic aromatic side chain for increased RNA affinity and reduced magnesium dependence. In combination with oxidative functional-ization at the C2 position of the imidazolone, this strategy yielded DMHBO\(^+\), which binds to the Chili aptamer with a low-nanomolar K\(_D\). Because of its highly red-shifted fluorescence emission at 592 nm, the Chili–DMHBO\(^+\) complex is an ideal fluorescence donor for Förster resonance energy transfer (FRET) to the rhodamine dye Atto 590 and will therefore find applications in FRET-based analytical RNA systems.
The hyperfine structures of the isoelectronic molecules CCO. CNN, and NCN in their triplet ground states (X\(^3 \sum ^-\)) are investigated by means of ab initio methods. The infrared frequencies and geometries are detennined and compared with experiment. Configuration selected multireference configuration interaction calculations in combination with perturbation theory to correct the wave function (MRD-CI/B\(_K\)) employing extended atomic orbital (AO) basis sets yielded very accurate hyperfine properties. The theoretical values for CCO are in excellent agreement with the experimental values determined by Smith and Weltner [J. Chem. Phys. 62,4592 (1975)]. For CNN, the first assignment of Smith and Weltner for the two nitrogen atoms has to be changed. A qualitative discussion of the electronic structure discloses no simple relation between the structure of the singly occupied orbitals and the measured hyperfine coupling constants. Vibrational effects were found to be of little importance.
Obligate human pathogenic Neisseria gonorrhoeae are the second most frequent bacterial cause of sexually transmitted diseases. These bacteria invade different mucosal tissues and occasionally disseminate into the bloodstream. Invasion into epithelial cells requires the activation of host cell receptors by the formation of ceramide-rich platforms. Here, we investigated the role of sphingosine in the invasion and intracellular survival of gonococci. Sphingosine exhibited an anti-gonococcal activity in vitro. We used specific sphingosine analogs and click chemistry to visualize sphingosine in infected cells. Sphingosine localized to the membrane of intracellular gonococci. Inhibitor studies and the application of a sphingosine derivative indicated that increased sphingosine levels reduced the intracellular survival of gonococci. We demonstrate here, that sphingosine can target intracellular bacteria and may therefore exert a direct bactericidal effect inside cells.
Post-transcriptional RNA modification methods are in high demand for site-specific RNA labelling and analysis of RNA functions. In vitro-selected ribozymes are attractive tools for RNA research and have the potential to overcome some of the limitations of chemoenzymatic approaches with repurposed methyltransferases. Here we report an alkyltransferase ribozyme that uses a synthetic, stabilized S-adenosylmethionine (SAM) analogue and catalyses the transfer of a propargyl group to a specific adenosine in the target RNA. Almost quantitative conversion was achieved within 1 h under a wide range of reaction conditions in vitro, including physiological magnesium ion concentrations. A genetically encoded version of the SAM analogue-utilizing ribozyme (SAMURI) was expressed in HEK293T cells, and intracellular propargylation of the target adenosine was confirmed by specific fluorescent labelling. SAMURI is a general tool for the site-specific installation of the smallest tag for azide-alkyne click chemistry, which can be further functionalized with fluorophores, affinity tags or other functional probes.
A tolane-modified 5-ethynyluridine as a universal and fluorogenic photochemical DNA crosslinker
(2023)
We report the fluorescent nucleoside ToldU and its application as a photoresponsive crosslinker in three different DNA architectures with enhanced fluorescence emission of the crosslinked products. The fluorogenic ToldU crosslinking reaction enables the assembly of DNA polymers in a hybridization chain reaction for the concentration-dependent detectio of a specific DNA sequence.
The reversible condensation of catechols and boronic acids to boronate esters is a paradigm reaction in dynamic covalent chemistry. However, facile backward hydrolysis is detrimental for stability and has so far prevented applications for boronate-based materials. Here, we introduce cubic boronate ester cages 6 derived from hexahydroxy tribenzotriquinacenes and phenylene diboronic acids with ortho-t-butyl substituents. Due to steric shielding, dynamic exchange at the Lewis acidic boron sites is feasible only under acid or base catalysis but fully prevented at neutral conditions. For the first time, boronate ester cages 6 tolerate substantial amounts of water or alcohols both in solution and solid state. The unprecedented applicability of these materials under ambient and aqueous conditions is showcased by efficient encapsulation and on-demand release of β-carotene dyes and heterogeneous water oxidation catalysis after the encapsulation of ruthenium catalysts.
Vibronically averaged values for K =0 and K = 1 bending levels in the energy range between 0 and 25 000 cm\(^{-1}\) are computed for the \(^{14}\)N, H, and D atoms in NH\(_2\), NHD, and ND\(_2\) The pure ab initio electronic potentials, as well as those derived by fitting of experimentally observed band positions are employed. Effects of vibronic coupling and local perturbations of close-lying levels belanging to different electronic states are discussed.
Potential energy and spectroscopic constants for the X\(^2 \sum^+ _\mu\) ground state of a;, were calculated by configuration-interaction (Cl) methods, using large basis sets with polarization and diffuse functions. From these CI wavefunctions, the isotropic (a\(_{iso}\)) and dipolar (A\(_{dip}\)) components of the hyperfine coupling constant were obtained. The effects of various s, p basis sets, polarization and diffuse functions, as well as the influence of reference configurations and configuration selection thresholds were investigated. The best values obtained are 35·31 G for a\(_{iso}\) and 29·440 for A\(_{dip}\)• tobe compared with experimental values of 37 ± 1 G and 32 ± 1 G, respectively. It is shown that the contributions to a1so of the K and L shells are opposite in sign, differing by about 4 G. Upon vibrational averaging, both a\(_{iso}\) and A\(_{dip}\) move towards smaller values as v increases. An adiabatic electron affinity of 2·46eV was obtained for CL\(_2\) , and a vertical electron detachment energy of 3·71 eV for Cl;.
Various structural possibilities for Si\(_3\)C\(_3\) clusters are investigated by ab initio calculations employing basis sets of double- and triple-zeta quality augmented by d polarization functions. Correlation effects are included by a second-order Moeller Piesset perturbation treatment. For the two lowest-lying structures higher-order correlation corrections and multi-reference effects are also included. Bonding features are investigated by two different types of population analyses to obtain insight into the nature of chemical bonding. A total of 17 stationary points were investigated, 14 of which correspond to local minima and three being transition states. The energetically lowest-lying structures are: A "pyramidlike" structure with various multicenter bonds, followed by a es symmetric isomer closely related to the ground state Si6 structure. Planar structures, favoured in small carbon clusters, lie higher in energy and are transition states. The lowest-lying triplet system is found to be the linear nonsymmetric Si - C-C-C-Si -Si structure, which is calculated to lie about 38 kcalfmole above the singlet ground state. A building-up principle based on bonding criteria is suggested for the occurence of the various structural possibilities.
Results ofan ab initio study ofthe hyperfine structure of the X\(^2\)A', A\(^2\) A" ( 1\(^2 \Pi\)) system ofthe formyl radical are presented. Special attention is paid to the analysis of the interplay between the vibronic and magnetic hyperfine etfects. The results of computations are in very good agreement with the available experimental findings. The values for the hyperfine coupling constants in lower bending Ievels of both electronic species are predicted.
The hyperfine coupling constants (isotropic hfcc and four Cartesian components of the ani~ tropic tensor) are calculated for all three atoms of C\(_2\)H in its three lowest-lying electronic states at various molecu)ar geometries by means of the ab initio configuration interaction ( MRO.CI) method. The off-diagonal electronic matrix elements involving the two species ofthe A' symmetry are also computed. A diabatic transforrnation is perforrned Jeading to simple geometrical depen· dences of the hyperline coupling constants.
The vibronically averaged values for tbe hyperfine coupling constants in the X\(^2 \sum\)-A\(^2 \Pi\) system of the ethynyl radical are computed by means of tbe ab initio metbod calculations. The results point at tbe importance of taking into account the coupling of a1l tbree electronic states in question ( I\(^2\)A', 2\(^2\)A', and 1\(^2\)A") for a reliable explanation of the available experimental findings. The mean values of the hfcc's for K = 0 and 1 levels in \(^{13}\)C\(_2\)H and \(^{13}\)C\(_2\)D in the energy range up to 6000 cm\(^{-1}\) are predicted.
The energy difference between the three lowest-lying isomers of C\(_6\) the linear \(^3 \sum ^-\) state and the two ring forms,the benzene structure (\(^1\)A\(_{18}\)) possessing D\(_{6h}\) symmetry and a distorted cyclic form ( \(^1\)A'\(_1\), D\(_{3h}\) symmetry) have been calculated using various ab initio methods. Variational methods such as multireference configuration interaction (MR-CI) and complete active space second order perturbatiOn treatment (CASPT2) have been applied, as weil as perturbational treatments and coupled cluster calculations (CCD). The correlation of all valence shell electrons is found to be important for a balanced description of the isomers of C\(_6\) . Methods which do not account for higher-order effects appropriately proved to be unsuitable for calculating the energy difference correctly. The results from multireference configuration interaction methods show that the isomers are close in energy with the cyclic forms somewhat lower than the linear form. The ring form possessing D\(_{3h}\) symmetry (\(^1\)A'\(_1\)} is found tobe the lowest-lying structure.
The present work consists of two parts. The first one deals with theoretical questions and tests the performance of orbitals obtained from a self-interaction free KS method, the LHFapproach, in multireference ab initio methods. The purpose of this part is to enable a more efficient computation of excitation energies, which is important for the spectroscopic characterization of many organic and bioorganic molecules. The second part focuses on bioorganic questions and studies the base pairing properties of the purine base xanthine in order to explain, e.g., the unusually high stability of selfpairing xanthine alanyl-PNA double strands and the mutagenicity of xanthine formed in DNA. Part1: In contrast to HF- and standard DFT-methods, the LHF-approach leads to a fully bound virtual orbital spectrum, because Coulomb self interactions are exactly canceled in the LHFansatz. Furthermore, the energies of the occupied orbitals are not upshifted, like it is the case for standard DFT-methods, so that Koopmans' theorem remains valid. In line with this, also the occupied LHF-orbitals are somewhat more compact than standard DFT-orbitals. The present work shows that both properties are of great benefit for MR methods. The virtual LHF-orbitals are well optimized and allow an efficient description of excited states and static correlation in both MRCI- and MRPT2-approaches. Furthermore, the higher compactness of the occupied LHF- compared to standard DFT-orbitals leads to a better description of the center ion of Rydberg states. However, for each of the two advantages mentioned at least one example molecule has been found, for which LHF-orbitals actually perform worse than HF-and/or standard DFT-orbitals. This shows, that even though LHF virtual orbitals allow an excellent MRCI- and MRPT2-description for the electronically excited states of a large number of molecules, this cannot be generalized and their performance needs to be tested for each individual case. In the second part of the present work, the base pairing properties of xanthine and xanthine derivatives were studied. The purpose of this part was to find an explanation for the unexpectedly high stability of the xanthine alanyl PNA double strand. Furthermore, it was analyzed, why xanthine, that is formed from guanine in DNA under chemical stress, is able to form mismatched base pairs with the pyrimidine base thymine. Stability of xanthine alanyl PNA: In the first step, the regioisomer present in the considered alanyl PNA was identified to be the N7-regioisomer of xanthine by a theoretical analysis of the 13C-NMR spectrum. To analyze the stability of the xanthine self-pairing, a simplified model was set up, in which the stability of the PNA double strand was explained solely by the energy contributions from H-bonding and base stacking. For that purpose, the dimerization and stacking energies for the xanthine-xanthine, guaninecytosine, adenine-thymine and xanthine-2,6-diaminopurine base pairs were computed using DFT and MP2 methods. Solvent effects were taken into account by the conductor like screening model. The influence of the peptide backbone on the stacking geometry was considered by force field optimizations. While the individual contributions from hydrogen bonding and stacking do not correlate with the melting temperature Tm, the sum of both correlates linearly with Tm. This correlation is somewhat surprising, because this means that the effects of the entropy and the molecular water environment either cancel or are similar for all systems compared. In this model, the stability of the xanthine selfpairing mainly stems from an enlarged stacking interaction, while the H-bonds give only minor contributions to the stability of the xanthine selfpaired double strand of alanyl-PNA. Base pairing properties of N9-Xanthine: The computation of the base pairing properties of N9-xanthine revealed a strong variation in the individual H-bond strengths for the selfpairing of xanthine, that range from -4 to -11 kcal/mol in the gas phase and -2.5 to -5 kcal/mol in polar solvent. By comparison with model systems it was shown that the strong variance of the H-bond strength is mainly due to attractive or repulsive secondary electrostatic interactions. For the homodimer of hypoxanthine it was shown that the increase of aromaticity in the pyrimidine ring upon dimer formation leads to a strengthening of the hydrogen bonds. Mutagenicity of hypoxanthine and xanthine: Several neutral and anionic Watson-Crick base pairs of xanthine were computed with MP2- and DFT-methods in order to explain the mutagenicity of hypoxanthine and xanthine. Also basepairs involving tautomeric forms of xanthine and hypoxanthine were considered. To evaluate the dimerization energies found, the dimers were classified into pairings that have the exact geometry of the canonical base pairs and those that realize a distorted Watson-Crick pairing mode. The computations show that a stable pairing which realizes the exact geometry of a canonical Watson Crick base pairing is only possible for the pairing of xanthine to cytosine, however, the base pairs are only weakly bound. The dimerization energies of both the neutral and the anionic pairing is around 0 kcal/mol, so that the xanthine-cytosine base pairs are incorporated into DNA solely because the base pairs fulfill the geometric demands of DNA polymerase, but it does not profit from any additional stabilization due to hydrogen bonding. The bonding that in the Watson-Crick pairing mode xanthine has almost no affinity to cytosine is in correspondence with the experimental result that the cytosine-xanthine base pair is incorporated into DNA at a much lower rate than the cytosine-guanine base pair, which has a very strong hydrogen bonding. While the affinity of xanthine to cytosine is very low, the computations predict that xanthine is able to form a stable Watson-Crick pairing with thymine. However, the pairing has a somewhat distorted Watson-Crick geometry, so that its high stability is outbalanced by the worsened fit to the binding pocket of DNA-polymerase. As a consequence, the xanthinethymine pairing is incorporated into DNA not at a faster, but only at a rate comparable to that of the xanthine-cytosine pairing.
Quantum chemical calculations of circular dichroism (CD) spectra in combination with experimental CD studies are one of the most efficient analytical tools for the elucidation of the three-dimensional structure of a chiral molecule. In the present work 18 chiral compounds of most different molecular structures and origins were investigated using various theoretical methods (the semiempirical CIS methods, the time-dependent DFT and DFT/MRCI approaches). The advantages and limitations of the applied methods were discussed in the context of the studied compounds. Furthermore, the last part of this work deals with the CD investigations of a chiral compound in the crystalline state. A well-known natural product with a specific conformation/CD spectrum behavior was used as a model compound to examine a novel solid-state CD method and to investigate the possibility of its improvement to provide a higher reliability for the assignment of the absolute configuration.
Activating Organic Phosphorescence via Heavy Metal–π Interaction Induced Intersystem Crossing
(2022)
Heavy‐atom‐containing clusters, nanocrystals, and other semiconductors can sensitize the triplet states of their surface‐bonded chromophores, but the energy loss, such as nonradiative deactivation, often prevents the synergistic light emission in their solid‐state coassemblies. Cocrystallization allows new combinations of molecules with complementary properties for achieving functionalities not available in single components. Here, the cocrystal formation that employs platinum(II) acetylacetonate (Pt(acac)\(_{2}\)) as a triplet sensitizer and electron‐deficient 1,4,5,8‐naphthalene diimides (NDIs) as organic phosphors is reported. The hybrid cocrystals exhibit room‐temperature phosphorescence confined in the low‐lying, long‐lived triplet state of NDIs with photoluminescence (PL) quantum yield (Φ\(_{PL}\)) exceeding 25% and a phosphorescence lifetime (τ\(_{Ph}\)) of 156 µs. This remarkable PL property benefits from the noncovalent electronic and spin–orbital coupling between the constituents.
Within this thesis the interactions between novel corannulene derivatives in solution as well as in the solid state by changing the imide residue of a literature known extended corannulene dicarboximide were investigated, in order to obtain a better understanding of the packing and possible charge transport in potential applications. Accordingly, the goal of the work was to synthesize and investigate an electron-poor corannulene bis(dicarboximide) based on previously published work but with higher solubility and less steric encumbrance in imide position to enable self-assembly in solution.
To obtain further insights into the conformational stability, structure and chiroptical properties of heavily twisted PBIs another aim of this thesis was the design, synthesis, and optoelectronic investigation of various fourfold directly arylated PBIs by substitution in bay position with smaller hydrocarbons with different steric demand, i.e., benzene, naphthalene and pyrene, which should be separable by chiral high performance liquid chromatography (HPLC).
As of yet, no concise study concerning the optical and electronic properties of differently core-substituted PBIs in the neutral as well as the mono- and dianionic state in solution is available, which also elucidates the origin of the different optical transitions observed in the absorption and emission spectra. Thus, in this thesis, the investigation of five PBI derivatives with different frontier energetic levels to produce a reference work of reduced PBIs was tackled.
Designing highly efficient purely organic phosphors at room temperature remains a challenge because of fast non-radiative processes and slow intersystem crossing (ISC) rates. The majority of them emit only single component phosphorescence. Herein, we have prepared 3 isomers (o, m, p-bromophenyl)-bis(2,6-dimethylphenyl)boranes. Among the 3 isomers (o-, m- and p-BrTAB) synthesized, the ortho-one is the only one which shows dual phosphorescence, with a short lifetime of 0.8 ms and a long lifetime of 234 ms in the crystalline state at room temperature. Based on theoretical calculations and crystal structure analysis of o-BrTAB, the short lifetime component is ascribed to the T\(^M_1\) state of the monomer which emits the higher energy phosphorescence. The long-lived, lower energy phosphorescence emission is attributed to the T\(^A_1\) state of an aggregate, with multiple intermolecular interactions existing in crystalline o-BrTAB inhibiting nonradiative decay and stabilizing the triplet states efficiently.
A highly sensitive short-wave infrared (SWIR, λ > 1000 nm) organic photodiode (OPD) is described based on a well-organized nanocrystalline bulk-heterojunction (BHJ) active layer composed of a dicyanovinyl-functionalized squaraine dye (SQ-H) donor material in combination with PC\(_{61}\)BM. Through thermal annealing, dipolar SQ-H chromophores self-assemble in a nanoscale structure with intermolecular charge transfer mediated coupling, resulting in a redshifted and narrow absorption band at 1040 nm as well as enhanced charge carrier mobility. The optimized OPD exhibits an external quantum efficiency (EQE) of 12.3% and a full-width at half-maximum of only 85 nm (815 cm\(^{-1}\)) at 1050 nm under 0 V, which is the first efficient SWIR OPD based on J-type aggregates. Photoplethysmography application for heart-rate monitoring is successfully demonstrated on flexible substrates without applying reverse bias, indicating the potential of OPDs based on short-range coupled dye aggregates for low-power operating wearable applications.
Herein, we report the one-pot synthesis of an electron-poor nanographene containing dicarboximide groups at the corners. We efficiently combined palladium-catalyzed Suzuki-Miyaura cross-coupling and dehydrohalogenation to synthesize an extended two-dimensional pi-scaffold of defined size in a single chemical operation starting from N-(2,6-diisopropylphenyl)-4,5-dibromo-1,8-naphthalimide and a tetrasubstituted pyrene boronic acid ester as readily accessible starting materials. The reaction of these precursors under the conditions commonly used for Suzuki-Miyaura cross-coupling afforded a C\(_{64}\) nanographene through the formation of ten C-C bonds in a one-pot process. Single-crystal X-ray analysis unequivocally confirmed the structure of this unique extended aromatic molecule with a planar geometry. The optical and electrochemical properties of this largest ever synthesized planar electron-poor nanographene skeleton were also analyzed.
Dipole moments and various spectroscopic constants of some low-lying electronic states of the CaF molecule have been calculated using the multireference single· and double-excitation configuration-interaction (MRD-CI) method. The electronic structure of the highly ionic molecule in various excited states can be explained in tenns of different polarisations of the mainly Cacentered valence electron in the field of the F\(^-\) anion. Plots of natural orbitals occupied by the valence electron in the different states give a qualitative picture of the charge distribution and provide a visualisation of the different polarisations of the valence electron in the various states. Comparisons with the electrostatic polarisation model ofTörring, Ernstand Kändler (TEK model) are made. The unknown A' \(^2 \Delta\) state is predicted to lie about 21200 cm\(^{-1}\) above the ground state.
A series of seven unusual dimeric naphthylisoquinoline alkaloids was isolated from the leaves of the tropical liana Ancistrocladus ealaensis J. Léonard, named cyclombandakamine A (1), 1-epi-cyclombandakamine A (2), and cyclombandakamines A3–7 (3–7). These alkaloids have a chemically thrilling structural array consisting of a twisted dihydrofuran-cyclohexenone-isochromene system. The 1′″-epimer of 4, cyclombandakamine A1 (8), had previously been discovered in an unidentified Ancistrocladus species related to A. ealaensis. Both lianas produce the potential parent precursor, mbandakamine A (9), but only A. ealaensis synthesizes the corresponding cyclized form, along with a broad series of slightly modified analogs. The challenging isolation required, besides multi-dimensional chromatography, the use of a pentafluorophenyl stationary phase. Featuring up to six stereocenters and two types of chiral axes, their structures were elucidated by means of 1D and 2D NMR, HRESIMS, in combination with oxidative chemical degradation experiments as well as chiroptical (electronic circular dichroism spectroscopy) and quantum chemical calculations. Compared to the ‘open-chain’ parent compound 9, these dimers displayed rather moderate antiplasmodial activities.
A unique series of six biaryl natural products displaying four different coupling types (5,10 , 7,10 , 7,80 , and 5,80) were isolated from the roots of the West African liana Ancistrocladus abbreviatus (Ancistrocladaceae). Although at first sight structurally diverse, these secondary metabolites all have in common that they belong to the rare group of naphthylisoquinoline alkaloids with a fully dehydrogenated isoquinoline portion. Among the African Ancistrocladus species, A. abbreviatus is so far only the second one that was found to produce compounds with such a molecular entity. Here, we report on four new representatives, named ancistrobreveines A–D (12–14, and 6). They were identified along with the two known alkaloids 6-O-methylhamateine (4) and entdioncophylleine A (10). The two latter naphthylisoquinolines had so far only been detected in Ancistrocladus species from Southeast Asia. All of these fully dehydrogenated alkaloids have in common being optically active despite the absence of stereogenic centers, due to the presence of the rotationally hindered biaryl axis as the only element of chirality. Except for ent-dioncophylleine A (10), which lacks an oxygen function at C-6, the ancistrobreveines A–D (12–14, and 6) and 6-O-methylhamateine (4) are 6-oxygenated alkaloids, and are, thus, typical ‘Ancistrocladaceae-type’ compounds. Ancistrobreveine C (14), is the first – and so far only – example of a 7,80-linked fully dehydrogenated naphthylisoquinoline discovered in nature that is configurationally stable at the biaryl axis. The stereostructures of the new alkaloids were established by spectroscopic (in particular HRESIMS, 1D and 2D NMR) and chiroptical (electronic circular dichroism) methods. Ancistrobreveine C (14) and 6-O-methylhamateine (4) exhibited strong antiproliferative activities against drug-sensitive acute lymphoblastic CCRF-CEM leukemia cells and their multidrugresistant subline, CEM/ADR5000.
The N,C-coupled naphthylisoquinoline alkaloid ancistrocladinium A belongs to a novel class of natural products with potent antiprotozoal activity. Its effects on tumor cells, however, have not yet been explored. We demonstrate the antitumor activity of ancistrocladinium A in multiple myeloma (MM), a yet incurable blood cancer that represents a model disease for adaptation to proteotoxic stress. Viability assays showed a potent apoptosis-inducing effect of ancistrocladinium A in MM cell lines, including those with proteasome inhibitor (PI) resistance, and in primary MM cells, but not in non-malignant blood cells. Concomitant treatment with the PI carfilzomib or the histone deacetylase inhibitor panobinostat strongly enhanced the ancistrocladinium A-induced apoptosis. Mass spectrometry with biotinylated ancistrocladinium A revealed significant enrichment of RNA-splicing-associated proteins. Affected RNA-splicing-associated pathways included genes involved in proteotoxic stress response, such as PSMB5-associated genes and the heat shock proteins HSP90 and HSP70. Furthermore, we found strong induction of ATF4 and the ATM/H2AX pathway, both of which are critically involved in the integrated cellular response following proteotoxic and oxidative stress. Taken together, our data indicate that ancistrocladinium A targets cellular stress regulation in MM and improves the therapeutic response to PIs or overcomes PI resistance, and thus may represent a promising potential therapeutic agent.
A striking feature of the metabolite profile of \(Ancistrocladus\) \(likoko\) (Ancistrocladaceae) is the exclusive production of 5,8\('\)-linked naphthylisoquinoline alkaloids varying in their OMe/OH substitution patterns and in the hydrogenation degree in their isoquinoline portions. Here we present nine new compounds of this coupling type isolated from the twigs of this remarkable Central African liana. Three of them, the ancistrolikokines E (9), E\(_2\) (10), and F (11), are the first 5,8\('\)-linked naphthyldihydroisoquinolines found in nature with \(R\)-configuration at C-3. The fourth new metabolite, ancistrolikokine G (12), is so far the only representative of the 5,8\('\)-coupling type that belongs to the very rare group of alkaloids with a fully dehydrogenated isoquinoline portion. Moreover, five new \(N\)-methylated naphthyltetrahydroisoquinolines, named ancistrolikokines A\(_2\) (13), A\(_3\) (14), C\(_2\) (5), H (15), and H\(_2\) (16) are presented, along with six known 5,8\('\)-linked alkaloids, previously identified in related African \(Ancistrocladus\) species, now found for the first time in \(A.\) \(likoko\). The structural elucidation was achieved by spectroscopic analysis (HRESIMS, 1D and 2D NMR) and by chemical (oxidative degradation) and chiroptical (electronic circular dichroism) methods. The new ancistrolikokines showed moderate to good preferential cytotoxic activities towards pancreatic PANC-1 cells in nutrient-deprived medium (NDM), without causing toxicity under normal, nutrient-rich conditions, with ancistrolikokine H\(_2\) (16) being the most potent compound.
A perylene bisimide dye bearing amide functionalities at the imide positions derived from amino acid L-alanine and a dialkoxy-substituted benzyl amine self-assembles into tightly bound dimers by π-π-stacking and hydrogen bonding in chloroform. In less polar or unpolar solvents like toluene and methylcyclohexane, and in their mixtures, these dimers further self-assemble into extended oligomeric aggregates in an anti-cooperative process in which even numbered aggregates are highly favoured. The stepwise transition from dimers into oligomers can not be properly described by conventional K\(_2\)-K model, and thus a new K\(_2\)-K aggregation model has been developed, which interpretes the present anti-cooperative supramolecular polymerization more appropriately. The newly developed K\(_2\)-K model will be useful to describe self-assembly processes of a plethora of other π-conjugated molecules that are characterized by a favored dimer species.
Certain fatty acids and sphingoid bases found at mucosal surfaces are known to have antibacterial activity and are thought to play a more direct role in innate immunity against bacterial infections. Herein, we analysed the antibacterial activity of sphingolipids, including the sphingoid base sphingosine as well as short-chain C\(_{6}\) and long-chain C\(_{16}\)-ceramides and azido-functionalized ceramide analogs against pathogenic Neisseriae. Determination of the minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC) demonstrated that short-chain ceramides and a ω-azido-functionalized C\(_{6}\)-ceramide were active against Neisseria meningitidis and N. gonorrhoeae, whereas they were inactive against Escherichia coli and Staphylococcus aureus. Kinetic assays showed that killing of N. meningitidis occurred within 2 h with ω–azido-C\(_{6}\)-ceramide at 1 X the MIC. Of note, at a bactericidal concentration, ω–azido-C\(_{6}\)-ceramide had no significant toxic effect on host cells. Moreover, lipid uptake and localization was studied by flow cytometry and confocal laser scanning microscopy (CLSM) and revealed a rapid uptake by bacteria within 5 min. CLSM and super-resolution fluorescence imaging by direct stochastic optical reconstruction microscopy demonstrated homogeneous distribution of ceramide analogs in the bacterial membrane. Taken together, these data demonstrate the potent bactericidal activity of sphingosine and synthetic short-chain ceramide analogs against pathogenic Neisseriae.
This thesis is divided into three parts with the main goal allocating novel antimicrobial compounds that could be used as future antibiotics. The first part aimed to evaluate the potential of plant suspension cultures for the production of antimicrobial proteins. The extracellular, intracellular and cell wall bound fractions of seven heterotrophic and photomixotrophic plant cell suspension cultures treated with nine different elicitors were tested for the elicitor dependent production of antimicrobial proteins. Bioactivities were tested against a selected panel of human isolates including Gram-positive and Gram-negative bacteria as well as fungi using the disc diffusion assay. The intracellular fractions of elicited cell cultures were more active than extracellular fractions while the cell wall bound fractions showed lowest activities. Among the 21 fractions tested, the intracellular fraction of Lavendula angustifolia elicited with DC3000 was most active against Candida maltosa. The second most active fraction was the intracellular fraction of Arabidopsis thaliana elicited with salicylic acid which was moreover active against all test strains. The antimicrobial activity of elicited Arabidopsis thaliana cell cultures was tested by bioautography to locate the antimicrobial proteins in the crude extract. The intracellular fraction of photomixotrophic Arabidopsis thaliana cells elicited with salicylic acid was selected for further gel filtration chromatography on S-200 column leading to the purification of one 19 kDa antimicrobially active protein, designated, AtAMP. Our findings suggest that elicited plant cell cultures may present a new promising alternative source of antimicrobial proteins. The second part comprises the isolation of actinomycetes associated with marine sponges and testing the bioactivities of new species for further investigations. Actinobacterial communities of eleven taxonomically different sponges that had been collected from offshore Ras Mohamed (Egypt) and from Rovinj (Croatia) were investigated by a culture-based approach using different standard media for isolation of actinomycetes and media enriched with aqueous sponge extract to target rare and new actinomycete species. Phylogenetic characterization of 52 representative isolates out of 90 based on almost complete sequences of genes encoding 16S rRNA supported their assignment to 18 different actinomycete genera. Altogether 14 putatively new species were identified based on sequence similarity values below 98.2% to other strains in the NCBI database. The use of M1 agar amended with aqueous sponge extract yielded a putative new genus related to Rubrobacter which highlighting the need for innovative cultivation protocols. Biological activity testing showed that five isolates were active against Gram-positives only, one isolate was active against Candida albicans only and one isolate showed activity against both groups of pathogens. Moreover, the antiparasistic activity was documented for four isolates. These results showed a high diversity of actinomycetes associated with marine sponges as well as highlighted their potential to produce anti-infective agents. The third part of the thesis focused on the isolation and structure elucidation of new bioactive compounds. Streptomyces strain RV15 recovered from sponge Dysidea tupha, was selected for further chemical analysis by virtue of the fact that it exhibited the greatest antimicrobial potential against Staphylococcus aureus as well as Candida albicans among the all tested strains. Moreover, members of the genus Streptomyces are well known as prolific producers of interesting pharmacologically active metabolites. Chemical analysis of the methanolic crude extract using different chromatographic tools yielded four new compounds. The structures of the new compounds were spectroscopically elucidated to be four new cyclic peptides, namely, cyclodysidins A-D. Their bioactivity was tested against different proteases, bacteria and Candida as well as tumor cell lines. The compounds did not show any significant activities at this point.
Three unusual heterodimeric naphthylisoquinoline alkaloids, named ealapasamines A-C (1–3), were isolated from the leaves of the tropical plant Ancistrocladus ealaensis J. Léonard. These ‘mixed’, constitutionally unsymmetric dimers are the first stereochemically fully assigned cross-coupling products of a 5,8′- and a 7,8′-coupled naphthylisoquinoline linked via C-6′ in both naphthalene portions. So far, only two other West and Central Ancistrocladus species were known to produce dimers with a central 6,6″-axis, yet, in contrast to the ealapasamines, usually consisting of two 5,8′-coupled monomers, like e.g., in michellamine B. The new dimers 1–3 contain six elements of chirality, four stereogenic centers and the two outer axes, while the central biaryl axis is configurationally unstable. The elucidation of the complete stereostructures of the ealapasamines was achieved by the interplay of spectroscopic methods including HRESIMS, 1D and 2D NMR (in particular ROESY measurements), in combination with chemical (oxidative degradation) and chiroptical (electronic circular dichroism) investigations. The ealapasamines A-C display high antiplasmodial activities with excellent half-maximum inhibition concentration values in the low nanomolar range.
From the leaves of a botanically and phytochemically as yet unexplored Ancistrocladus liana discovered in the rainforests of the Central region of the Democratic Republic of the Congo in the vicinity of the town of Ikela, six new naphthylisoquinoline alkaloids were isolated, viz., two constitutionally unsymmetric dimers, the mbandakamines B\(_3\) (3) and B\(_4\) (4), and four related 5,8′-linked monomeric alkaloids, named ikelacongolines A–D (5a, 5b, 6, and 7). The dimers 3 and 4 are structurally unusual quateraryls comprising two 5,8′-coupled monomers linked via a sterically strongly constrained 6′,1′′-connection between their naphthalene units. These compounds contain seven elements of chirality, four stereogenic centers and three consecutive chiral axes. They were identified along with two known related compounds, the mbandakamines A (1) and B\(_2\) (2), which had so far only been detected in two Ancistrocladus species indigenous to the Northwestern Congo Basin. In addition, five known monomeric alkaloids, previously found in related Central African Ancistrocladus species, were isolated from the here investigated Congolese liana, three of them belonging to the subclass of 5,8′-coupled naphthylisoquinoline alkaloids, whereas two compounds exhibited a less frequently occurring 7,8′-biaryl linkage. The stereostructures of the new alkaloids were established by spectroscopic (in particular HRESIMS, 1D and 2D NMR), chemical (oxidative degradation), and chiroptical (electronic circular dichroism) methods. The mbandakamines B\(_3\) (3) and B\(_4\) (4) displayed pronounced activities in vitro against the malaria parasite Plasmodium falciparum and the pathogen of African sleeping sickness, Trypanosoma brucei rhodesiense.
In this work the catalytic activity of nanodiamond particles with different dopants and surface terminations and of diamond nanomaterials funtionalized with ruthenium-based photocatalysts was investigated, illustrating materials application in photoredox chemistry and the photo(electro)catalytic reduction of CO2. Regarding the application of diamond nanomaterials in photocatalysis, methods to fabricate and characterize several (un)doped nanoparticles with different surface termination were successfully developed. Various photocatalysts, attached to nanodiamond particles via linker systems, were tested in photoredox catalysis and the photo(electro)catalytic reduction of CO2.