Refine
Has Fulltext
- yes (872)
Year of publication
- 2021 (872) (remove)
Document Type
- Journal article (872) (remove)
Language
- English (872) (remove)
Keywords
- COVID-19 (19)
- inflammation (16)
- virtual reality (13)
- inorganic chemistry (11)
- SARS-CoV-2 (10)
- boron (10)
- immunohistochemistry (8)
- breast cancer (7)
- ischemic stroke (7)
- machine learning (7)
- neuroinflammation (7)
- prostate cancer (7)
- remote sensing (7)
- Aspergillus (6)
- MRI (6)
- Parkinson's disease (6)
- RNA (6)
- anxiety (6)
- biomarker (6)
- children (6)
- deep learning (6)
- depression (6)
- multiple sclerosis (6)
- oxidative stress (6)
- DNA damage (5)
- T cells (5)
- adrenocortical carcinoma (5)
- atherosclerosis (5)
- cytokines (5)
- density functional calculations (5)
- imaging (5)
- infection (5)
- luminescence (5)
- macrophages (5)
- metabolism (5)
- mice (5)
- multiple myeloma (5)
- obesity (5)
- stroke (5)
- therapeutic drug monitoring (5)
- time series (5)
- 3D printing (4)
- Apis mellifera (4)
- Arabidopsis thaliana (4)
- Germany (4)
- MODIS (4)
- Sentinel-2 (4)
- antimicrobial stewardship (4)
- attention-deficit/hyperactivity disorder (ADHD) (4)
- boranes (4)
- cancer (4)
- cytotoxicity (4)
- drought (4)
- echocardiography (4)
- epidemiology (4)
- evolution (4)
- human-computer interaction (4)
- magnetic resonance imaging (4)
- melt electrowriting (4)
- mouse (4)
- neural networks (4)
- organic chemistry (4)
- perception (4)
- physical activity (4)
- positron emission tomography (4)
- psychology (4)
- systematic review (4)
- toxicity (4)
- validation (4)
- ADHD (3)
- B cells (3)
- Bordetella pertussis (3)
- Boron (3)
- FGFR (3)
- Google Earth Engine (3)
- N-heterocyclic carbenes (3)
- Roux-en-Y gastric bypass surgery (3)
- South Africa (3)
- Staphylococcus aureus (3)
- X-ray crystallography (3)
- acid sphingomyelinase (3)
- additive manufacturing (3)
- antimicrobial resistance (3)
- apoptosis (3)
- aromaticity (3)
- augmented reality (3)
- behavior (3)
- biocompatibility (3)
- biodiversity (3)
- biomarkers (3)
- blood–brain barrier (3)
- borylation (3)
- case report (3)
- cerebrospinal fluid (3)
- chirality (3)
- climate change (3)
- deadwood (3)
- dosimetry (3)
- ecological momentary assessment (3)
- emotions (3)
- fluorescence spectroscopy (3)
- fluoroarene (3)
- forensic neuropathology (3)
- healing (3)
- host-pathogen interaction (3)
- hypofractionation (3)
- immunomodulation (3)
- immunotherapy (3)
- inflammatory bowel disease (3)
- inhibition (3)
- insects (3)
- interview (3)
- kinetics (3)
- mRNA (3)
- major depression (3)
- medicine (3)
- melanoma (3)
- mortality (3)
- motivation (3)
- mouse model (3)
- mouse models (3)
- myocardial infarction (3)
- neurodegeneration (3)
- neutrophils (3)
- oligodendrocytes (3)
- optogenetics (3)
- oxidation (3)
- paraganglioma (3)
- perception and action (3)
- permafrost (3)
- pheochromocytoma (3)
- phosphorylation (3)
- proteins (3)
- psoriasis (3)
- public health (3)
- radicals (3)
- sphingolipids (3)
- structural biology (3)
- structure elucidation (3)
- super-resolution microscopy (3)
- survey (3)
- thrombosis (3)
- tissue engineering (3)
- total knee arthroplasty (3)
- transcriptomics (3)
- water oxidation (3)
- 3D reconstruction (2)
- 53BP1 (2)
- AVHRR (2)
- BDNF (2)
- BGK approximation (2)
- CSF (2)
- CT angiography (2)
- CXCR4 (2)
- Ca\(^{2+}\) signalling (2)
- Candida albicans (2)
- DFT (2)
- DNA repair (2)
- EAE (2)
- EEG (2)
- Earth observation (2)
- Europe (2)
- Formicidae (2)
- Gaussian approximation (2)
- Halcyon (2)
- KEAP1 (2)
- LC/MS (2)
- MSC (2)
- NDVI (2)
- NET (2)
- NK cells (2)
- Neisseria gonorrhoeae (2)
- PD-1 (2)
- PET (2)
- RNA polymerase II (2)
- SARS‐CoV‐2 (2)
- SMN (2)
- Sentinel-1 (2)
- TIMELINE (2)
- Tanzania (2)
- Tourette syndrome (2)
- Trypanosoma brucei (2)
- Western Cape (2)
- Wilms' tumor (2)
- ab initio calculations (2)
- abscisic acid (ABA) (2)
- active zone (2)
- acute heart failure (2)
- acute myeloid leukemia (2)
- acute respiratory distress syndrome (2)
- adaptation (2)
- adaptive immunity (2)
- adipose-derived stromal cells (2)
- adjuvant treatment (2)
- adolescence (2)
- aging (2)
- algorithm (2)
- alloreactive T cells (2)
- aminotroponiminates (2)
- aneurysm (2)
- animal models (2)
- anorexia nervosa (2)
- antennal lobe (2)
- antidepressants (2)
- aortic arch (2)
- arrhythmia (2)
- autoimmune disease (2)
- avatars (2)
- big five (2)
- biofabrication (2)
- biokinetics (2)
- biological techniques (2)
- biology (2)
- biomass (2)
- biomedicine, general (2)
- bioprinting (2)
- bismuth (2)
- bleeding (2)
- bone mineral density (2)
- boronateesters (2)
- bronchopulmonary dysplasia (2)
- cage compounds (2)
- caloric restriction (2)
- cancers and neoplasms (2)
- carbene ligands (2)
- cardiac magnetic resonance (2)
- cardinality constraints (2)
- cardiomyopathy (2)
- cardiovascular genetics (2)
- cartilage regeneration (2)
- cationic species (2)
- central complex (2)
- ceramides (2)
- cerebellar tDCS (2)
- cerebrovascular disorders (2)
- change detection (2)
- chemistry (2)
- chromophore (2)
- chronic heart failure (2)
- chronotype (2)
- circadian clock (2)
- circulation type (2)
- classical conditioning (2)
- cochlear implantation (2)
- cognition (2)
- colorectal cancer (2)
- comet assay (2)
- complementary alternative medicine (2)
- computational chemistry (2)
- copper (2)
- count time series (2)
- critical care (2)
- cross-coupling (2)
- crowdsensing (2)
- dSTORM (2)
- deep brain stimulation (2)
- dental trauma (2)
- dermatology (2)
- desmosomes (2)
- development (2)
- diagnosis (2)
- diagnostic markers (2)
- diborane (2)
- dilated cardiomyopathy (2)
- direct-acting antivirals (2)
- disease (2)
- distribution (2)
- drug discovery (2)
- drug repurposing (2)
- dynamic covalent chemistry (2)
- education (2)
- electroactive (2)
- electrohydrodynamic (2)
- electronic properties and materials (2)
- electrophilic substitution (2)
- electrophysiology (2)
- electrospinning (2)
- elevated plus-maze (2)
- embodiment (2)
- empathy (2)
- endocytosis (2)
- endothelium (2)
- environmental health (2)
- ethanol (2)
- etymology (2)
- exercise (2)
- exosomes (2)
- experimental autoimmune encephalomyelitis (2)
- extracellular matrix (2)
- extracellular vesicles (2)
- eye movements (2)
- facial expression (2)
- fatigue (2)
- fear conditioning (2)
- fibrin (2)
- fluorescence (2)
- forensic neurotraumatology (2)
- forest management (2)
- functional diversity (2)
- functionalization (2)
- gait (2)
- genome (2)
- genomics (2)
- geoarchaeology (2)
- global change (2)
- glycoprotein VI (2)
- guard cell (2)
- health-related quality of life (2)
- heart failure (2)
- heart rate (2)
- hematology (2)
- heterocycles (2)
- homogeneous catalysis (2)
- homogenous catalysis (2)
- human-centered design (2)
- hyaluronic acid (2)
- hybrid materials (2)
- hydrogels (2)
- hypercortisolism (2)
- hypophosphatasia (2)
- hypoxia (2)
- ideomotor theory (2)
- image-guided radiation therapy (2)
- immersion (2)
- immersive technologies (2)
- immune system (2)
- immunoassay (2)
- immunosenescence (2)
- impedance spectroscopy (2)
- incisional hernia (2)
- injury (2)
- interactome (2)
- intestinal epithelial barrier (2)
- intraoperative imaging (2)
- iron (2)
- iron oxide nanoparticles (2)
- isomerization (2)
- isothermal titration calorimetry (2)
- kidney (2)
- kinematic alignment (2)
- kinetic model (2)
- large vessel occlusion (2)
- lenalidomide (2)
- liraglutide (2)
- loneliness (2)
- long-term outcome (2)
- mHealth (2)
- magic (2)
- magnesium phosphate cement (2)
- malignant tumors (2)
- mass spectrometry (2)
- mechanism (2)
- mechanotransduction (2)
- medical research (2)
- megakaryocytes (2)
- meiosis (2)
- meningioma (2)
- mental disorders (2)
- meta-analysis (2)
- methionine restriction (2)
- microglia (2)
- microscopy (2)
- migrants (2)
- mineralization (2)
- minimally invasive (2)
- molecular biology (2)
- molecular imaging (2)
- molecular medicine (2)
- molecular neuroscience (2)
- motor control (2)
- mucoepidermoid carcinoma (2)
- multi-fluid mixture (2)
- multisensory processing (2)
- neural stem cells (2)
- neuroanatomy (2)
- neuroblastoma (2)
- neurogenesis (2)
- neurology (2)
- neuropeptides (2)
- neuroprotection (2)
- neuroscience (2)
- neurosurgery (2)
- neurotrophins (2)
- nickel (2)
- occupational medicine/industrial medicine (2)
- optimization (2)
- organic photodiodes (2)
- organoids (2)
- osteoporosis (2)
- outcome (2)
- p53 (2)
- pathogens (2)
- pediatric (2)
- pharmacogenetics (2)
- pharmacokinetics (2)
- pharmacology/toxicology (2)
- phenology (2)
- photocatalysis (2)
- photophysics (2)
- plasticity (2)
- platelets (2)
- pleomorphic adenoma (2)
- pollen tube (2)
- polycaprolactone (2)
- polymer processing (2)
- polymorphism (2)
- postoperative nausea and vomiting (2)
- prediction (2)
- prefrontal cortex (2)
- pregnancy (2)
- preterm infants (2)
- primary care (2)
- probability (2)
- protein (2)
- pulmonary hypertension (2)
- pulse wave velocity (2)
- pyrene (2)
- quality of experience (2)
- radical (2)
- real-time (2)
- recombination (2)
- recurrence (2)
- regulatory T cells (2)
- rehabilitation (2)
- rhodopsin (2)
- rotation (2)
- ruthenium complexes (2)
- salivary gland tumors (2)
- salt stress (2)
- scaffold (2)
- scientific guidelines (2)
- secondary prevention (2)
- segmentation (2)
- sex differences (2)
- signal transduction (2)
- smoking (2)
- social cognition (2)
- soil (2)
- spatial presence (2)
- specificity (2)
- squaraine dyes (2)
- stomata (2)
- stress (2)
- surgery (2)
- surgical site infections (2)
- synthetic methods (2)
- tMCAO (2)
- telecommunication spectral range (2)
- text comprehension (2)
- theranostics (2)
- therapy (2)
- thrombo-inflammation (2)
- tight junction (2)
- timing (2)
- tinnitus (2)
- total joint arthroplasty (2)
- total knee replacement (2)
- transcription (2)
- translation (2)
- treatment (2)
- trypanosoma (2)
- tumor (2)
- tumor microenvironment (2)
- type 2 diabetes (2)
- viral infection (2)
- visual system (2)
- wall shear stress (2)
- water (2)
- (AB)\(_{n}\) segmented copolymers (1)
- (dis-)embeddedness (1)
- 1,2-additionreaction (1)
- 1,2-benzisothiazolinone (1)
- 177Lu SPECT/CT imaging (1)
- 1p36 deletion syndrome (1)
- 22q11.2 deletion syndrome (1)
- 3 D rotational fluoroscopy (1)
- 3D X-ray microscopy (1)
- 3D cell cultures (1)
- 3D fluoroscopy (1)
- 3D microfiber (1)
- 3D powder printing (1)
- 3D tumor model (1)
- 3D-reconstruction methods (1)
- 3DTK toolkit (1)
- 3R (1)
- 3‐D electrical resistivity imaging (1)
- 4D flow (1)
- 4D flow MRI (1)
- 5-HTTLPR (1)
- 7 T (1)
- 7T (1)
- <sup>18</sup>F-FDG (1)
- <sup>68</sup>Ga-Pentixafor (1)
- A2a-R receptor (1)
- ACM (1)
- ACTH (1)
- ALI culture (1)
- ALPH (1)
- ALPH1 (1)
- ALS (1)
- ALS treatment (1)
- ALT (1)
- AML (1)
- APOBEC3G (1)
- ARIA (1)
- ARVC (1)
- ASC (1)
- ASCs (1)
- ATMP (1)
- ATP-DnaA complex (1)
- ATRX (1)
- ATTRv amyloidosis (1)
- AYAs (1)
- AZD4547 (1)
- Ab interno trabeculectomy (1)
- Accountability (1)
- Adenylate cyclase toxin (1)
- Africa (1)
- Africa south of the equator (1)
- African agriculture (1)
- African trypanosome (1)
- African trypanosomes (1)
- Aggeneys (1)
- Agro-ecology (1)
- Akt (1)
- Alento hydrological observatory (1)
- Alkyne (1)
- Alternaria (1)
- Aluminium-copper (1)
- Alzheimer's disease (1)
- Alzheimer’s disease (1)
- Amyotrophic Lateral Sclerosis (ALS) (1)
- Amyotrophic Lateral Sclerosis Assessment Questionnaire 5 (ALSAQ-5) (1)
- Angola (1)
- Antarctic ice sheet (1)
- Antarctica (1)
- ApaH (1)
- ApaH like phosphatase (1)
- ArcCHECK (1)
- Arthropod (1)
- Asia (1)
- Asian Englishes (1)
- Aspergillus fumigatus (1)
- Atharvaveda (1)
- Aureobasidium (1)
- AurisID (1)
- B (1)
- B-cell (1)
- B4GALT7 gene (1)
- BB/OKL rats (1)
- BCG (1)
- BCOR (1)
- BCORL1 (1)
- BM (1)
- BMP-6 (1)
- BN compounds (1)
- BON-1 (1)
- BRAF (1)
- BRENDA (1)
- BSA (1)
- BSS directive (1)
- Bavaria (1)
- Bavarian Forest (1)
- BayPass (1)
- Bayesian approach (1)
- Benzyne (1)
- Berchtesgaden (1)
- Beryllium (1)
- Big Five (1)
- Biochemistry (1)
- Blepharoplastik (1)
- Bloch oscillations (1)
- Blue Spot Analysis (1)
- Bombus terrestris (1)
- Bone Mineral Density (1)
- Brassica napus (1)
- Brockett (1)
- Broken Hill (1)
- Bruchpilot (1)
- Bruton's tyrosine kinase inhibitor CC-292 (1)
- Business Process Models (1)
- C-H activation (1)
- C-terminal domain (1)
- CA2+ channels (1)
- CA3 pyrimidal cells (1)
- CAD detection (1)
- CAR T (1)
- CAR T-cell (1)
- CAR-T-cell (1)
- CARAT (1)
- CCR7 (1)
- CD28 (1)
- CD30 (1)
- CD319 (1)
- CD4+ T-cells (1)
- CD56 (1)
- CDH13 (1)
- CDL (1)
- CETCH cycle (1)
- CLRN2 (1)
- CMR (1)
- CMV (1)
- CMV-specific cellular immunity (1)
- CNS cancer (1)
- CNS diseases (1)
- CO2 (1)
- CO2-sequestration (1)
- COH29 (1)
- COI (1)
- COMT (1)
- COPD (1)
- COVID‐19 (1)
- CRC (1)
- CRISPR-Cas Systems (1)
- CRISPR-Cas9 (1)
- CRISPR/Cas9 (1)
- CRLs (1)
- CS1 (1)
- CT (1)
- CT perfusion (1)
- CT-angiography (1)
- CTLA-4 (1)
- CTNNB1 (1)
- CXCL12-abundant reticular (CAR)-cells (1)
- CYP11B enzymes (1)
- CYP2C9 (1)
- CYP3A4 (1)
- CaMKII (1)
- Ca\(^{2+}\) indicator (1)
- Cabozantinib (1)
- Caco2 cells (1)
- Cadherin-13 (CDH13) (1)
- Caenorhabditis elegans (C. elegans) (1)
- Candida auris (1)
- Canis lupus familiaris (1)
- Caputo fractional derivative (1)
- Carabidae (1)
- Cardiac dysfunction| Brain natriuretic peptide (1)
- Cataglyphis (1)
- Cavity quantum electrodynamics (1)
- Cell death and comet assay (1)
- Cerebrolysin (1)
- Charged aerosol detector (CAD) (1)
- Chili RNA Aptamer (1)
- Chlamydomonas reinhardtii (1)
- Chrysomelidae (1)
- Claudin2 (1)
- Clinical Neuroradiology (1)
- Co-Crystal Structures of Chili RNA (1)
- Collective effects in quantum optics (1)
- Colombia (1)
- Coptic (1)
- Covid19 (1)
- Crespi effect (1)
- Crohn's disease (1)
- Crohn’s Disease (1)
- Cryoelectron Microscopy (1)
- Cryoelectron microscopy (1)
- Cryptic species (1)
- CubeSat (1)
- CubeSat GNSS (1)
- Curculionidae (1)
- Cushing’s disease (1)
- Cushing’s syndrome (1)
- Cutaneous metastatic Crohn’s disease (1)
- Cx43 (1)
- Cyclization (1)
- CysLTR1 (1)
- Cysteine‐Rich Domain (CRD) (1)
- D-norm (1)
- DBH (1)
- DBT (1)
- DNA Damage Repair (1)
- DNA nanotechnology (1)
- DNA replication initiation (1)
- DNA-PK (1)
- DNA/RNA sensors (1)
- DOACs (1)
- DOT1B (1)
- DOTA-EB-TATE (1)
- DPP III enzyme (1)
- DRD4 (1)
- DSC2 (1)
- DSG2 (1)
- DUB inhibitor (1)
- DeepSqueak (1)
- Deoxyribozymes (1)
- Digital platforms (1)
- Dopaminergic PAM cluster neurons (1)
- Drosophila (1)
- Dsg2 (1)
- E/e’ (1)
- EBER in situ hybridization (1)
- ECM coating (1)
- EDA-NOCV (1)
- EEG frequency band analysis (1)
- EEG preprocessing (1)
- EEG processing (1)
- EGF (1)
- EGFR (1)
- EJMA-D-19-00287 (1)
- EMT (1)
- EPM (1)
- ERBB receptors (1)
- ERG (1)
- ERK (1)
- ERT (1)
- ESCAlife (1)
- ESPED (1)
- EU member states (1)
- EVI (1)
- EVT (1)
- EZH1 (1)
- EZH2 (1)
- Earth Observation (1)
- Ecosystem services (1)
- Egypt (1)
- El Niño (1)
- Electrochemistry (1)
- Emotional behavior (1)
- Enzyme‐Linked Immunosorbent Assay (1)
- Epitranscriptomics (1)
- Epstein-Barr virus (1)
- Escherichia coli (1)
- EuroQol Five Dimension Five Level Scale (EQ-5D-5L) (1)
- European beech (1)
- Eye Movement Modeling Examples (1)
- E−X bond activation (1)
- FAP (1)
- FAPI PET/CT (1)
- FARS1 (1)
- FBXW7 (1)
- FDG (1)
- FDG PET/CT (1)
- FGF (1)
- FGF-pathway (1)
- FGF/FGFR signalling (1)
- FGFR signaling (1)
- FGFR1 (1)
- FIB-SEM (1)
- FINCA (1)
- FL spectroscopy (1)
- Fascia transversalis (1)
- Fatty acids (1)
- Fifth Dynasty (1)
- Fluoro(perfluoroalkyl) phosphoranes (1)
- Fluorogenic RNA Aptamers (1)
- Fn14 (1)
- Frustrated Lewis Pairs (1)
- Fungal traits (1)
- Fungiplex Candida Auris (1)
- Fusarium (1)
- G-quadruplexes (1)
- GABA-A receptor (1)
- GABA\(_{A}\) receptor (1)
- GABA\(_{B}\) (1)
- GABAergic neurons (1)
- GCA (1)
- GCC (1)
- GDNF (1)
- GDNF5 (1)
- GIST (1)
- GMP (1)
- GPI-anchor (1)
- GVHD (1)
- GWAS (1)
- Gamsberg (1)
- German Hepatitis C-Registry (1)
- Germylenes (1)
- Gibbs activation energy (1)
- Google Earth Engine (GEE) (1)
- Grad-seq (1)
- Gradient boosted trees (GBT) (1)
- Graph eigenvalues (1)
- Graph products (1)
- Graphnullity (1)
- Grave’s disease (1)
- Grundvorstellung (1)
- GvHD (1)
- H+-atpase (1)
- H3K27me3 (1)
- HA modifiedCNF membranes (1)
- HCV cure (1)
- HEV (1)
- HFQ (1)
- HFpEF (1)
- HIV (1)
- HIV-1 (1)
- HMD (Head-Mounted Display) (1)
- HMGB1 (1)
- HNSC (1)
- HPP (1)
- HRMS (1)
- HRQL (1)
- HTTP adaptive video streaming (1)
- Halictidae (1)
- HeLa cells (1)
- Head and neck cancers (1)
- Heart failure (1)
- Hepatitis B Virus (1)
- Hepatitis E (1)
- Herodotus (1)
- Hexadehydro-Diels-Alder (1)
- High-performance liquid chromatography (HPLC) (1)
- Histone gamma H2AX (1)
- Hodgkin lymphoma (1)
- Holothuria spinifera (1)
- Horowitz Quotient (1)
- Hypophosphatasia (1)
- Hyrcanian forest (1)
- ICD-CRT (1)
- ICM (1)
- ICU treatment (1)
- IDSA (1)
- IFN-γ ELISpot (1)
- IGRT (1)
- III–V quantum dot (1)
- IL-6 (1)
- IL2 branching (1)
- ILEX (1)
- IR (1)
- IRF4 (1)
- IS education (1)
- Ibuprofen (1)
- IcaR (1)
- IgG (1)
- InSAR (1)
- IncuCyte\(^®\)S3 (1)
- Induced Pluripotent Stem Cells (1)
- Insect pests (1)
- IntelliCage (1)
- Intelligent Virtual Agents (1)
- Interleukin (1)
- Inzisionale Hernie (1)
- Inzisionalhernie (1)
- Ips typographus (1)
- Isheru (1)
- J-aggregates (1)
- JUN (1)
- K+ channels (1)
- KIT (1)
- Kaposi sarcoma (1)
- Keller–Segel model (1)
- Kerneldensity estimation (1)
- Ki67 (1)
- Kinetoplastea (1)
- Kinetoplastida (1)
- Krüppel-like factor (1)
- L-arginine (1)
- L929 (1)
- LC-MS/MS (1)
- LDA (1)
- LDL cholesterol (1)
- LESA (1)
- LINGO-1 (1)
- LMNA (1)
- LRIG1 (1)
- LV dilatation (1)
- LVNC (1)
- Land Surface Temperature (1)
- Landsat time series (1)
- Landscape ecology (1)
- Lao PDR (1)
- Legume crops (1)
- Leistenhernie (1)
- Lepidoptera (1)
- Lernkurve (1)
- Lewis acid (1)
- Lewis acid/base adducts (1)
- Lewis acidity (1)
- Lewis adducts (1)
- LiDAR (1)
- Lichtheimia (1)
- Lieberoser Heide (1)
- Life expectancy (1)
- Ligand effects (1)
- Linea alba (1)
- Local rings (1)
- Luminescence (1)
- Lyapunov functions (1)
- MAINZPouch (1)
- MALDI imaging (1)
- MASK (1)
- MAX (1)
- MDR (1)
- MHC I (1)
- MHC II (1)
- MIBG scintigraphy (1)
- MITF-low (1)
- MPFL (1)
- MS (1)
- MS-18 (1)
- MSCI (1)
- MSCs (1)
- MSIS (1)
- MYC (1)
- MYCN (1)
- Macrophage Migration Inhibitory Factor (MIF) (1)
- Mann-Kendall test (1)
- Matlab (1)
- Mbt (1)
- Mediterranean environment (1)
- Merkel cell carcinoma (1)
- Minimalinvasiv (1)
- Minimalinvasive Leistenhernienversorgung (1)
- Mitotane (1)
- Molecular mechanism (1)
- Molecular neuroscience (1)
- Molnupiravir (1)
- Molnupiravir-Induced RNA Mutagenesis Mechanism (1)
- Myocardial-perfusion SPECT (1)
- N ligands (1)
- N-Heterocyclic Carbene Adducts (1)
- N-Heterocyclic Carbenes (1)
- N-Heterocyclic carbenes (1)
- N-heterocyclic carbene (1)
- NA (1)
- NEC (1)
- NFAT (1)
- NFE2L2 (1)
- NFκB (1)
- NHLRC2 (1)
- NIHSS (1)
- NOAC (1)
- NOP10 (1)
- NR3C1 (1)
- NRF2 (1)
- NSCLC (1)
- NSG animals (1)
- Namibia (1)
- Negative geotaxis (1)
- Neisseria meningitidis (1)
- Nile delta (1)
- Nile flow (1)
- Nrf2 (1)
- OHIP-G14 (1)
- OHRQoL (1)
- OXTR (1)
- Olea (1)
- One Health (1)
- OprO (1)
- OprP (1)
- Optical Spectroscopy (1)
- Optogenetics (1)
- Organoazides (1)
- Organoids (1)
- Oshana (1)
- Osteoporosis (1)
- P97 (1)
- PAK4 (1)
- PCR (1)
- PCR diagnostics (1)
- PD-L1 (1)
- PDE2 (1)
- PER (1)
- PET/CT (1)
- PI-3-kinase (1)
- PIA/ica (1)
- PLAG1 rearrangement (1)
- PMR (1)
- PPGL (1)
- PSMA (1)
- PTA (1)
- PTCL (1)
- PTEN (1)
- PU.1 (1)
- PWV (1)
- PYY3-36 (1)
- Pacific Ocean (1)
- Paprosky (1)
- Parkinson’s disease (1)
- Phase II trials (1)
- PhenoCam (1)
- Phoenix dactylifera (1)
- Photocatalysis (1)
- Picea mariana (1)
- PknB (1)
- Placebo (1)
- Plant-insect interactions (1)
- Platform economy (1)
- Plumbylenes (1)
- Poisson surface reconstruction (1)
- Polanyi (1)
- Pollination (1)
- Posteriore Komponentenseparation (1)
- Pre‐Ligand Assembly Domain (PLAD) (1)
- Primary hyperparathyroidism (pHPT) (1)
- Process Model Comprehension (1)
- Pseudomonas (1)
- Pseudomonas aeruginosa (1)
- Pseudotsuga menziesii (1)
- Purpureocillium (1)
- Q. brantii (1)
- QGP-1 (1)
- Qi gong (1)
- Quantitative structure-property relationship modeling (QSPR) (1)
- Quantum optics with artificial atoms (1)
- R-GECO1 cytosolic Ca\(^{2+}\) reporter (1)
- R-loop (1)
- R-type (1)
- RET6 (1)
- RHO (1)
- RIM-binding protein (1)
- RNA Expression (1)
- RNA Modification (1)
- RNA modification (1)
- RNA probe (1)
- RNA splicing (1)
- RNA structure (1)
- RNA virus (1)
- RNA-Dependent RNA Polymerase (1)
- RNA-binding proteins (1)
- RNA-dependent RNA polymerase (1)
- RNA-sequencing (1)
- RNAScope (1)
- RNAseq (1)
- RNR (1)
- ROCK (1)
- RRID: AB_2315425 (1)
- RRID: AB_2337244 (1)
- RRM2 (1)
- RT-PCR (1)
- Rab (1)
- Radiation sensitivity (1)
- Radioiodine Therapy (1)
- Raman probes (1)
- Razumikhin method (1)
- Remdesivir (1)
- Resistance training (1)
- Retromuskuläres Netz (1)
- Retrorektus Netz (1)
- Riemann hypothesis (1)
- Robotik (1)
- Rodos (1)
- Ruthenium (1)
- Ruxolitinib (1)
- S-glutathionylation (1)
- SAR (1)
- SAR backscatters (1)
- SARS-CoV (1)
- SARS-CoV- 2 (1)
- SARS-CoV-2 polymerase (1)
- SARS-CoV2 Replication Impairment (1)
- SBAS (1)
- SCC (1)
- SCN5a (1)
- SDG 11.3.1 (1)
- SEMA3A (1)
- SEQ (1)
- SIRS (1)
- SLAC1 (1)
- SLAMF7 (1)
- SLC6A4 (1)
- SOFA Score (1)
- SPRED (1)
- SPRED2 (1)
- SWOT (1)
- Sarcopenia (1)
- Scedosporium (1)
- Schiff base chemistry (1)
- Schistosomiasis (1)
- Schizosaccharomyces pombe (1)
- Sebennitic (1)
- Sentinel-1 single-look complex data (1)
- Sentinel-2 multispectral indices (1)
- Serom (1)
- Shockley–Read–Hall (1)
- Silylenes (1)
- Single‐Molecule Localization Microscopy (SMLM) (1)
- Site-Specific RNA Cleavage (1)
- Sjögren’s syndrome (1)
- Sleep fragmentation (1)
- Small-holder agriculture (1)
- Soil and Water Assessment Tool (SWAT) (1)
- Solanum lycopersicum (1)
- Sonic hedgehog (1)
- Southern Annular Mode (1)
- Spinal Orthosis (1)
- Stannylenes (1)
- Staphylococcal infection (1)
- Staphylococcus aureus / drug effects (1)
- Stp (1)
- Stroke (1)
- Structural Biology (1)
- Superagonistic antibody (1)
- Superradiance & subradiance (1)
- Suzuki coupling (1)
- Synergy (1)
- Synthetic Functional RNAs (1)
- Sápmi (1)
- T cell activation (1)
- T cell subpopulations (1)
- T-cell (1)
- T-cell non-Hodgkin's lymphomas (1)
- T-cell transfer (1)
- T-cells (1)
- T-lymphocytes (1)
- TB (1)
- TEER (1)
- TERRA RNA (1)
- TERT (1)
- TGF-alpha (1)
- TGF-ß3 (1)
- TGFβ signaling (1)
- TIND (1)
- TNAP (1)
- TNF ligand superfamily (1)
- TNF receptor (TNFR) family (1)
- TNPI (1)
- TPC1 channel (1)
- TRP channel (1)
- TTR knockdown (1)
- TTR stabilization (1)
- TanDEM-X (1)
- Tell Basta (1)
- Tet‐inducible system (1)
- Th1 cells (1)
- Th17 (1)
- Th9 (1)
- Theory of Mind (1)
- Tp63 (1)
- Tr1 (1)
- Transcription (1)
- Triple co-culture (1)
- Triton X 100 (1)
- Tropical agriculture (1)
- Troponin (1)
- Tuberculosis (1)
- Turkish (1)
- Type 1 diabetes (1)
- UKZ (1)
- USP25 (1)
- USP28 (1)
- USP8 (1)
- UV/Vis spectroscopy (1)
- Umbilikalhernie (1)
- VLA-1 (1)
- VLSM (1)
- VPP mouse model (1)
- VSOP (1)
- Vancomycin / administration & dosage (1)
- Vancomycin / chemistry (1)
- Vancomycin / pharmacology (1)
- Vedic (1)
- Ventrale Hernie (1)
- Verticillium dahliae (1)
- Verticillium longisporum (1)
- Vif (1)
- WBC (1)
- WSS (1)
- WST test (1)
- Wade’s rules (1)
- Waldeyer’s tonsillar ring (1)
- Water Framework Directive (1)
- Western blot (1)
- Whole Body Vibration (1)
- Wilm's tumor (1)
- Wilms tumor (1)
- Wnt (1)
- World Heritage Sites (1)
- Wuerzburg Grief Inventory (WGI) (1)
- X-ray (1)
- X-ray Crystallography (1)
- X-ray microscopy (1)
- XAV-939 (1)
- XPD helicase (1)
- XR (1)
- XR-artificial intelligence combination (1)
- XR-artificial intelligence continuum (1)
- YB-1 (1)
- Yoga (1)
- Zagros Forests (1)
- Zero-divisor graphs (1)
- Zucker fatty fa/fa rats (1)
- [18F]FDG PET/CT (1)
- [18F]FDG-PET-CT (1)
- [\(^{223}\)Ra]RaCl\(_{2}\) (1)
- [\(^{68}\)Ga] Pentixafor (1)
- [n]helicenes (1)
- \(^{1}\)HNMR (1)
- abdominal lymph node metastases (1)
- abiotic (1)
- abiotic stress (1)
- aboveground biomass (1)
- abscisic-acid activation (1)
- absorption (1)
- acceptance of gay men (1)
- accessibility (1)
- accessibility analysis (1)
- acculturation (1)
- acetic acid (1)
- acetones (1)
- acetonitrile (1)
- acetylsalicylic acid (1)
- acid (1)
- acid/base adducts (1)
- acinic cell carcinoma (1)
- acrophobia (1)
- actigraphy (1)
- actin (1)
- actin messenger RNA (1)
- action (1)
- active self (1)
- acupressure (1)
- acute ITP (1)
- acute Respiratory Distress Syndrome (1)
- acute appendicitis (1)
- acute graft-versus host disease (1)
- acute graft-versus-host disease (1)
- acute ischemic stroke (1)
- acute myeloid leukaemia (1)
- acute respiratory distress syndrome (ARDS) (1)
- acute toxicity (1)
- adaptive directional microphone setting (1)
- adaptive immune response (1)
- adaptive radiotherapy (1)
- adenoid cystic carcinoma (ACC) (1)
- adenylate cyclase toxin (1)
- adipose tissue (1)
- adipose tissue-derived stromal cells (1)
- adjuvant platinum-based chemotherapy (1)
- admission screening (1)
- adolescent (1)
- adolescents (1)
- adoptive cell therapy (1)
- adrenal (1)
- adrenal gland (1)
- adrenal incidentaloma (1)
- adrenal tumors (1)
- adrenocortical cancer (1)
- adrenocortical cell line (1)
- adrenocortical tissues (1)
- adrenocortical tumors (1)
- adsorption (1)
- adults with congenital heart disease (1)
- adverse drug reactions (1)
- adverse pulmonary outcomes (1)
- advertising (1)
- advertising effectiveness (1)
- aerobic threshold (1)
- afatinib (1)
- affective computing (1)
- age (1)
- age differences (1)
- age-related hearing loss (1)
- age-related macular degeneration (1)
- age-related macular degeneration (AMD) (1)
- agency (1)
- agents (1)
- aging and cell death (1)
- agreeableness (1)
- agricultural soils (1)
- agriculture (1)
- air quality (1)
- airway epithelia (1)
- albumin (1)
- alcohol (1)
- alerts (1)
- algorithms (1)
- alkali metal (1)
- alkaline phosphatase (1)
- alkyne complexes (1)
- allatostatin‐A (1)
- allelic replacement (1)
- allergy (1)
- allosteric modulation (1)
- alloys (1)
- alpha-7 nicotinic acetylcholine receptor (1)
- alpha-synuclein (1)
- alpha‐synuclein (1)
- alpha‐synuclein propagation (1)
- alpha‐synuclein seeding (1)
- alternative methods (1)
- altitudinal gradient (1)
- aluminum granuloma (1)
- alveolar bone (1)
- alveolar bone loss (1)
- alveolar fibrosis (1)
- alveolar regeneration (1)
- alveolar ridge augmentation (1)
- alveolar‐capillary barrier (1)
- alzheimer's disease (1)
- ambiguous plaid 4 (1)
- ambrosia beetle (1)
- ambrosia fungi (1)
- amination (1)
- amino acid (1)
- amino acid analogues (1)
- aminoacyl‐tRNA synthetases (1)
- aminyl radicals (1)
- amniotic infection (1)
- amoeboid cell migration (1)
- amphids (1)
- amphimixis (1)
- amplitude criterion (1)
- amyloid beta (1)
- amyloid cardiomyopathy (1)
- amyloid-β (Aβ) (1)
- amyloid‐directed antibodies (1)
- amyotrophic lateral sclerosis (ALS) (1)
- analgesia (1)
- analgesics (1)
- analytical model building (1)
- anamnesis tool (1)
- anastomosis (1)
- anatomy (1)
- ancient Egypt (1)
- ancient Indo-European languages (1)
- anciety-like behavior (1)
- androgen deprivation therapy (1)
- anergy (1)
- aneurysmal subarachnoid hemorrhage (1)
- aneurysms (1)
- animal study (1)
- anioniccarbene (1)
- anisotropic porous structures (1)
- ankle (1)
- ant brain (1)
- antenatal inflammation (1)
- antenna (1)
- anthocyanins (1)
- anthropogenic drivers (1)
- anti-TNFRSF receptor (TNFR) antibodies (1)
- anti-bacterial agents / administration & dosage (1)
- anti-bacterial agents / chemistry (1)
- anti-bacterial agents / pharmacology (1)
- anti-depressive treatment (1)
- anti-myocardial (1)
- antiaromaticity (1)
- antibacterial activity (1)
- antibacterials (1)
- antibiotic prescription (1)
- antibiotic prescription behavior (1)
- antibiotic resistance (1)
- antibiotic therapy (1)
- antibiotic use (1)
- antibiotics (1)
- antibodies (1)
- anticancer activity (1)
- anticoagulant therapy (1)
- antidepressant (1)
- antiemetics (1)
- antifungal susceptibility (1)
- antigen loss (1)
- antigen processing and presentation (1)
- antigen testing (1)
- antigenic variation (1)
- antigens (1)
- antimicrobials (1)
- antimony (1)
- antinuclear antibodies (1)
- antioxidant nutrients (1)
- antioxidative (1)
- antiproliferative (1)
- antisense RNA (1)
- antitermination (1)
- antiviral agents (1)
- antiviral treatment (1)
- anxiety disorders (1)
- aorta ring (1)
- aortic adventitia (1)
- aortic valve disease percutaneous intervention (AVDP) (1)
- apatite nanoparticles (1)
- aphids (1)
- apomixis (1)
- app (1)
- application design (1)
- applied mathematics (1)
- applied physics (1)
- approach-avoidance (1)
- approach-avoidance conflict (1)
- approaches in textbooks (1)
- approved drugs (1)
- aquaculture (1)
- aquatic plants (1)
- arbenes (1)
- arginine metabolism (1)
- arrhythmogenic cardiomyopathy (1)
- arterial elasticity (1)
- arterial stiffening (1)
- arthrography (1)
- artifacts (1)
- artificial bones (1)
- artificial intelligence (1)
- artificial intelligence education (1)
- artificial intelligence literacy (1)
- artificial neural networks (1)
- artificial photosynthesis (1)
- artificial rearing (1)
- arylmetalate (1)
- asiatische Augen (1)
- asolescence (1)
- assistive devices (1)
- asthma (1)
- asymptomatic screening (1)
- asymptotic analysis (1)
- atlas‐based volumetry (1)
- atmospheric circulation (1)
- atopic dermatitis (1)
- attachment (1)
- attention (1)
- attention deficit hyperactivity disorder (1)
- attention deficit/hyperactivity disorder (1)
- attentional reweighting (1)
- attention‐deficit (1)
- attenuation of disease (1)
- audiometry (1)
- auditory pathway (1)
- auditory timer (1)
- augmentation (1)
- augmented Lagrangian (1)
- augmented Lagrangian method (1)
- autoantibodies (1)
- autoantibody (1)
- autoimmunity (1)
- autologous (1)
- automatic processing (1)
- automation (1)
- automation & robotics (1)
- automixis (1)
- autonomic nervous system (1)
- autophagosomes (1)
- autophagy (1)
- auxiliary DO (1)
- avatar embodiment (1)
- avelumab (1)
- averted gaze (1)
- avulsion (1)
- axi-cel (1)
- azaborinines (1)
- azobenzenes (1)
- baclofen (1)
- bacterial genetics (1)
- bacterial immune evasion (1)
- bacteriology (1)
- bacteriophage (1)
- baghdadite (1)
- balance (1)
- ball (1)
- barcoding (1)
- bark and ambrosia beetles (1)
- barrier (1)
- barrier models (1)
- basal forebrain cholinergic neurons (1)
- base metal deposit (1)
- basic (laboratory) research / science (1)
- basic mental model (1)
- bateman functions (1)
- bee pollinator (1)
- behavior change (1)
- behavior problems (1)
- behaviour (1)
- beryllium (1)
- beta diversity (1)
- beta-D-glucan (1)
- bibliometric analysis (1)
- bibliometrics (1)
- bile salt (1)
- bio-printability (1)
- biochemical relapse free survival (1)
- biocompatible Materials (1)
- biocrusts activity (1)
- biodiversity gradients (1)
- biodiversity hypotheses (1)
- biodosimetry (1)
- biofilm regulation (1)
- biofluid (1)
- biofuel (1)
- biogenic amines (1)
- bioimaging (1)
- bioinformatic (1)
- bioinformatic clustering (1)
- bioinspired membrane (1)
- bioisosterism (1)
- biological fluorescence (1)
- biomanufacturing (1)
- biomarker combination (1)
- biomarker of exposure (1)
- biomarker prediction (1)
- biomechanical (1)
- biomechanical evaluation (1)
- biomimetic 3D tissue model (1)
- bioreactor culture (1)
- biosignals (1)
- biospecies (1)
- bipolar disorder (1)
- bismuth amides (1)
- bistable perception (1)
- black carbon AOD (1)
- black yeast (1)
- bladder cancer (1)
- bleeding score (1)
- blink rate (1)
- block copolymers (1)
- blood brain barrier (1)
- blood coagulation (1)
- blood pressure (1)
- blood samples (1)
- blood-nerve barrier (1)
- blood–labyrinth barrier (1)
- bodies (1)
- body esteem (1)
- body mass index (1)
- body ownership (1)
- body representation (1)
- body size (1)
- bohemian forest ecosystem (1)
- bond dissociation energies (1)
- bone (1)
- bone adaptation (1)
- bone augmentation (1)
- bone cement (1)
- bone substitutes (1)
- bone tissue engineering (1)
- bone turnover (1)
- bone wires (1)
- borates (1)
- boroles (1)
- boron heterocycles (1)
- boron reagents (1)
- boronate ester (1)
- boronate esters (1)
- boronates (1)
- bortezomib (1)
- boryl anion (1)
- borylene (1)
- borylene complexes (1)
- borylenes (1)
- bounded input bounded output stability (1)
- brain (1)
- brain asymmetry (1)
- brain cancer (1)
- brain laterality (1)
- brain metastases (1)
- brain tumor (1)
- brain-computer interface (1)
- brain-retina axis (1)
- brainstem auditory evoked potentials (1)
- breast cancer model (1)
- breed predisposition (1)
- brown adipose tissue (1)
- bulky damages recognition (1)
- burn wound (1)
- butyrylcholinesterase (1)
- c-MYC (1)
- cGMP (1)
- cadherins (1)
- calcification (1)
- calcium (1)
- calcium signalling (1)
- calcofluor white staining (1)
- calipered (1)
- callous-unemotional traits (1)
- cancer associated fibroblasts (1)
- cancer genomics (1)
- cancer of unknown primary (CUP) (1)
- cancer patients (1)
- cancer predisposition syndromes (1)
- cancer therapy (1)
- cancer-associated fibroblast (1)
- cancer-induced bone disease (1)
- cancers (1)
- canine (1)
- capillary electrophoresis (1)
- carbamate (1)
- carbon fiber (1)
- carborane (1)
- carboxylation (1)
- cardiac MRI (1)
- cardiac function (1)
- cardiac imaging (1)
- cardiac rehabilitation (1)
- cardiac rehabilitation standards (1)
- cardiac surgery (1)
- cardioprotection (1)
- cardiovascular diseases (1)
- cardiovascular magnetic resonance (1)
- caregiver burden (1)
- carotid artery disease (1)
- cartilage (1)
- cartilage defectex vivo model (1)
- cartilage defects (1)
- cartilage test system (1)
- catalytic (1)
- catecholamines (1)
- catenation (1)
- cell biology (1)
- cell counting (1)
- cell death (1)
- cell labeling (1)
- cell migration (1)
- cell morphology (1)
- cell proliferation (1)
- cell surface (1)
- cell surface proteome (1)
- cell viability (1)
- cell wall (1)
- cell-free therapeutics (1)
- cell-matrix interaction (1)
- cellular signalling networks (1)
- cementoclasts (1)
- cementum (1)
- central auditory pathway (1)
- ceramide (1)
- cerebellum (1)
- cerebral ischemia (1)
- cerebral metastases (1)
- cerebropulmonary disease (1)
- cerebrosides (1)
- cervical spine (1)
- challenging behaviours (1)
- chaperone (1)
- chaperone HFQ (1)
- chaperones (1)
- charge separation (1)
- charge transfer (1)
- checkpoint blocker (1)
- chemical crosslinking (1)
- chemical similarity (1)
- chemokine receptor (1)
- chemotypes (1)
- childhood (1)
- childhood interstitial lung disease (1)
- childhood leukemia (1)
- children´s interstitial lung disease (chILD) lipoid pneumonia (1)
- chiral separation (1)
- chirality transfer (1)
- cholesterol pneumonia (1)
- cholesterol pneumonitis (1)
- choline acetyltransferase (1)
- chondrocytes (1)
- chondrogenic differentiation (1)
- chordotonal organ (1)
- choroidal neovascularization (CNV) (1)
- chromatin structure (1)
- chromophores (1)
- chromosomal genes (1)
- chronic hepatitis C (1)
- chronic rhinosinusitis (1)
- chronic stimulation (1)
- chylomicron (1)
- ciliostasis (1)
- circadian rhythms (1)
- circuits (1)
- circuits and circuit components (1)
- circular dichroism (1)
- circular polarized luminescence (1)
- circulation patterns (1)
- cisplatin resistance (1)
- clathrin (1)
- click CuAAC synthesis (1)
- click chemistry (1)
- click-chemistry (1)
- climate related trends (1)
- climatological water deficit (1)
- clinical approach (1)
- clinical data warehouse (1)
- clinical malformations (1)
- clinical study (1)
- clinical trial (1)
- clinical trials (1)
- clonal hematopoiesis of indeterminate potential (1)
- closed head injury (1)
- closure AV fistula/AVM (CLAV) (1)
- clustering (1)
- co-authorships (1)
- co-extremality coefficient (1)
- co-inventorships (1)
- coagulase-negative staphylococci (1)
- coagulation (1)
- coagulation and hemostasis (1)
- coal (1)
- coal fire (1)
- coastal zone (1)
- cochlear implant (1)
- coercive measures (1)
- cognitive function (1)
- cognitive neuroscience (1)
- cognitive psychology (1)
- cognitive reappraisal (1)
- coherence (1)
- coherent forecasting (1)
- cold pressor test (1)
- collaboration (1)
- collagen (1)
- collagen membranes (1)
- collagen type I hydrogel (1)
- collateral circulation (1)
- collections (1)
- collective refusal to supply (1)
- colloid (1)
- colloidal nanostructures (1)
- colloids (1)
- color lightness (1)
- color tuning (1)
- color-coded (1)
- colour patterns (1)
- columnar phases (1)
- combinatorial drug predictions (1)
- commercial kits (1)
- common variable immunodeficiency (CVID) (1)
- community detection (1)
- community settings (1)
- community trait analysis (1)
- comorbidities (1)
- compaction (1)
- comparative genomics (1)
- compatible solutes and other metabolites (1)
- complexity (1)
- compound refractive X-ray lenses (1)
- comprehension (1)
- compressive load (1)
- computational (1)
- computational biology and bioinformatics (1)
- computational cell biology (1)
- computed tomography (1)
- computer science (1)
- computers as social actors (1)
- condition prediction (1)
- conduct problems (1)
- conduction disease (1)
- cone beam CT (1)
- cone-beamcomputed tomography (1)
- conecontinuity type constraint qualification (1)
- configurational stability (1)
- conflicts (1)
- confluent hypergeometric functions (1)
- conformational restriction (1)
- conforming (1)
- congenital heart-deffects (1)
- coniferous species (1)
- conjugated oligomers (1)
- connective tissue disorder (1)
- consensus (1)
- conservative treatment (1)
- constitution (1)
- contact (1)
- contact-kinin system (1)
- continence mechanism (1)
- continent cutaneous urinary diversion (1)
- continuous norming (1)
- continuous performance task (CPT) (1)
- conversational agent (1)
- conversational agents (1)
- conversion (1)
- convolutional neural network (1)
- convolutional neural networks (1)
- cooperative self-assembly (1)
- coordination polymers (1)
- coping strategies (1)
- copy-number variation (1)
- coracohumeral distance (1)
- coracohumeral impingement (1)
- corazonin (1)
- coronary artery bypass grafting (1)
- coronary artery disease (1)
- coronavirus disease 2019 (1)
- correction (1)
- corticosteroids (1)
- cortisol (1)
- cortisol-producing adenoma (1)
- cost-sensitive learning (1)
- course of recovery (1)
- covalent organic frameworks (1)
- cpYFP cytosolic pH reporter (1)
- craniovertebral junction (1)
- creatine kinase (1)
- critically ill patients (1)
- crop management (1)
- cross pollination (1)
- cross-cultural comparison (1)
- crowdsourced measurements (1)
- crown-root fracture (1)
- cryptochrome (1)
- crystal engineering (1)
- cumulene (1)
- curriculum research (1)
- curve fitting (1)
- custom made implant (1)
- cutaneous T-cell-lymphoma (1)
- cutaneous angiosarcoma (1)
- cutibacteria (1)
- cuticular chemistry (1)
- cuticular hydrocarbons (1)
- cyanine dyes (1)
- cyanoborate (1)
- cybersickness (1)
- cyclic (alkyl)(amino)carbenes (1)
- cyclic GMP (1)
- cyclic adenosine monophosphate (1)
- cyclic alkyl(amino)carbene (1)
- cyclic mechanical stretch (1)
- cyclic stretch (1)
- cyclic testing (1)
- cycling (1)
- cyclization (1)
- cycloaddition (1)
- cyclooligomerization (1)
- cyclophanes (1)
- cyclotrimerization (1)
- cysteine restriction (1)
- cysteine synthase inhibitor (1)
- cyto-compatibility (1)
- cytochrome P450 3A4 (CYP3A4) (1)
- cytogenetics (1)
- cytokine release (1)
- cytokinin kinetin (1)
- cytoskeleton (1)
- danio rerio (1)
- data analysis (1)
- data pool (1)
- data quality (1)
- data smoothing (1)
- date palm (1)
- dauer (1)
- de-commodification (1)
- deadwood enrichment (1)
- deafness (1)
- death (1)
- decarbonylation (1)
- decay (1)
- decision-making (1)
- decline of democracy (1)
- decreasing autonomy (1)
- deep lakes (1)
- deep learning–artificial neural network (DL-ANN) (1)
- defects (1)
- deformable image registration (1)
- deformational cranial asymmetry (1)
- degradable bone substitutes (1)
- degradable implant (1)
- degradation (1)
- degradation profile (1)
- degrees of freedom in internal energy (1)
- dehydrocoupling (1)
- deictic reference (1)
- democracy (1)
- demyelination (1)
- dendritic cells (1)
- dengue infections (1)
- dengue serotypes (1)
- dengue virus (1)
- dental hard tissue defects (1)
- dental implants (1)
- deoxyribozymes (1)
- dependable software (1)
- depressive symptoms (1)
- deracemization (1)
- derivation (1)
- descriptors (1)
- design (1)
- design cycle (1)
- desmin (1)
- desmocollin-2 (1)
- desmoglein-2 (1)
- desmosome (1)
- detected magnetic-resonance (1)
- detection limits (1)
- detection time simulation (1)
- determining gene-product (1)
- detoxification (1)
- detrended fluctuation analysis (1)
- developmental biology (1)
- developmental disabilities (1)
- diabetes (1)
- diabetic neuropathy (1)
- diabetic retinopathy (1)
- diagnostics (1)
- diary study (1)
- diastolic dysfunction (1)
- diastolic function (1)
- diborenes (1)
- diborynes (1)
- dictator game (1)
- diet (1)
- differential expression (1)
- diffuse interface models (1)
- digital agriculture (1)
- digital game (1)
- digital learning (1)
- digital phenotyping (1)
- digital subtraction angiography (1)
- digital transformation of health and care (1)
- digitization (1)
- diketopyrrolopyrroles (1)
- dimensions of proximity (1)
- dinuclear (1)
- diode (1)
- diphosphanes (1)
- direct cortical stimulation (1)
- direct gaze (1)
- directional deep brain stimulation (1)
- discrimination training (1)
- disease progression (1)
- disembodiment (1)
- disk herniation (1)
- distributed practice (1)
- disturbance gradient (1)
- disturbed humid area (1)
- diversity (1)
- diversity gradients (1)
- division of labor (1)
- docking (1)
- dog (1)
- dominant intraprostatic lesion (1)
- dose accumulation (1)
- dose evaluation (1)
- dose rate (1)
- dose to OARs (1)
- dosimetry, QA (1)
- double negative B cells (1)
- dovitinib (1)
- drainage ratio (1)
- drillable bone cement (1)
- drilling (1)
- drug abuse (1)
- drug delivery (1)
- drug design (1)
- drug impurities (1)
- drug liberation (1)
- drug-delivery (1)
- drug–drug interactions (DDIs) (1)
- dry-mounted samples (1)
- dual fluorescence (1)
- dual-energy (1)
- durotaxis (1)
- dye chemistry (1)
- dyes/pigments (1)
- dystonia (1)
- e-coach (1)
- e-health (1)
- e-learning (1)
- earth observation (1)
- eating disorders (1)
- ecological intensification (1)
- ecological modelling (1)
- ecological stoichiometry (1)
- ecology (1)
- eculizumab (1)
- editorial board (1)
- edoxaban (1)
- education for sustainable development (1)
- effectors (1)
- efficacy (1)
- eicosanoids (1)
- ejection fraction (1)
- elective surgery (1)
- electrocardiography (1)
- electroencephalogram (1)
- electroencephalogram (EEG) (1)
- electroencephalography (1)
- electroencephalography (EEG) (1)
- electrohydrodynamics (1)
- electromagnetic navigation (1)
- electromagnetics (1)
- electron cryo microscopy (1)
- electron cryo-microscopy (1)
- electron microscopy (1)
- electronic collective variables (1)
- electronic data capture (1)
- electronic health records (1)
- electronic wavefunction (1)
- element translocation (1)
- elementary modes (1)
- elevation (1)
- elevation gradient (1)
- elevational gradient (1)
- elicitors (1)
- elotuzumab (1)
- embedded templating (1)
- embedding techniques (1)
- embolism/thrombosis (1)
- emission (1)
- emotion (1)
- emotion recognition (1)
- emotional influence (1)
- emotional state (1)
- emotional states (1)
- emphysema (1)
- empirical evidence (1)
- employee stress (1)
- enamines (1)
- enantiomerization (1)
- encapsulation (1)
- encephalitis lethargica (1)
- endocannabinoids (1)
- endocarditis (1)
- endochondral ossification (1)
- endodontic management (1)
- endogenous pulmonary stem cells (1)
- endoribonuclease (1)
- endoscopic full thickness resection (eFTR) (1)
- endoscopic groin hernia repair (1)
- endosomes (1)
- endothelial cell infection (1)
- endovascular (1)
- endovascular therapy (1)
- endurance exercise (1)
- endurance training (1)
- energy homeostasis (1)
- engineering (1)
- engraftment syndrome (1)
- enhanced recovery after surgery (1)
- enrichment (1)
- ensemble optimal control problems (1)
- enteric glial cells (1)
- enteric nervous system (1)
- enterohepatic recirculation (1)
- entropy minimization (1)
- envelopment (1)
- environmental association analysis (1)
- environmental impact (1)
- environmental justice (1)
- environmental sound (1)
- environmental variability (1)
- enzyme (1)
- enzyme kinetics (1)
- enzyme replacement therapy (1)
- enzymes (1)
- ephitelial cells (1)
- epidermis (1)
- epidural analgesia (1)
- epigenetics (1)
- epithelial cells (1)
- epithelial markers (1)
- epithelial salivary gland (1)
- epithelial-mesenchymal transition (1)
- epithelium (1)
- epitope mapping (1)
- epitranscriptomics (1)
- equilibrium (1)
- ergometer (1)
- esohypotropia (1)
- essential tremor (1)
- estimation error (1)
- evans blue (1)
- event detection (1)
- event-related potentials-ERP (1)
- evidence (1)
- evidence‐based medicine (1)
- evolutionary genetics (1)
- evolutionary genomics (1)
- exact matching (1)
- exchangeable D-norms (1)
- excimer formation (1)
- exciplexes (1)
- exciton coupling (1)
- exciton‐polaritons (1)
- executive function (1)
- executive functions (1)
- exercise testing (1)
- exercise tolerance (1)
- exercise training (1)
- existence of solutions (1)
- exocytosis (1)
- exotic species (1)
- expansion microscopy (1)
- expected shortfall (1)
- expectiles (1)
- experiment (1)
- experimental design (1)
- experimental stroke (1)
- expert opinion (1)
- expertise framing (Min5-Max 8) (1)
- expertise in visual imagery (1)
- expository texts (1)
- exposure therapy (1)
- expression (1)
- external beam radiotherapy (EBRT) (1)
- exteroception (1)
- extinction risk (1)
- extracellular matrix disorganisation (1)
- extracellular-regulated kinase 5 (1)
- extraction efficiency (1)
- extramedullary (1)
- extramedullary disease (1)
- extrapulmonary tuberculosis (1)
- extravascular lung water (1)
- extremal exchangeable D-norms (1)
- extremities (1)
- extrusion of hiMPC-containing bioinks alginate + collagen type I (1)
- extrusion-based 3D printing (1)
- eye infection (1)
- eye tracking (1)
- eye-tracking (1)
- facial electromyography (1)
- factor XII (1)
- false belief (1)
- familial DCM (1)
- familial amyloid polyneuropathy (FAP) (1)
- family (1)
- family physicians (1)
- farm forestry (1)
- farmland woodlots (1)
- farringtonite (1)
- fat absorption (1)
- fatal traumatic brain injury (1)
- fatty liver (1)
- fatty liver disease (1)
- fear (1)
- fear generalization (1)
- fear-relevant training (1)
- feature selection (1)
- feedback (1)
- female (1)
- female reproductive tract (1)
- femtochemistry (1)
- ferroelectrics (1)
- ferroptosis (1)
- fertility (1)
- fever (1)
- fibers (1)
- fibroblast activation protein (1)
- fiction (1)
- fiducial registration error (1)
- finger movements (1)
- finger-tapping task (1)
- flagellar pocket (1)
- flagellar pocket collar (1)
- flg22 (1)
- flight characteristics (1)
- flood (1)
- flooding (1)
- flow (1)
- flow cytometry (1)
- flow dynamics (1)
- fluid collectives (1)
- fluid simulation (1)
- fluorescence imaging (1)
- fluorescent dyes (1)
- fluorescent probes (1)
- fluorescent recombinant vaccinia virus (1)
- fluorinated ligands (1)
- fluorine (1)
- fluorine-18 (1)
- fluoroscopy (1)
- flux (1)
- flux balance analysis (1)
- flux measurements (1)
- folding landscapes (1)
- follow up (1)
- foot (1)
- foraging (1)
- foraging activities (1)
- forced swimming (1)
- foreclosure (1)
- foreign language learning and teaching (1)
- forest biodiversity (1)
- forest ecosystem science (1)
- forest ecosystems (1)
- forestry (1)
- fosmidomycin (1)
- fpVCT (1)
- fractal analysis (1)
- fractionation membranev (1)
- fracture (1)
- fracture repair (1)
- fracture risk (1)
- fractures, bone (1)
- frailty (1)
- frameless systems (1)
- framework (1)
- free flap surgery (1)
- frontotemporal dementia (1)
- fuel wood (1)
- full-field microscopy (1)
- full-thickness resection device (FTRD) (1)
- fumaric acid esters (1)
- functional status (1)
- functional traits (1)
- fundamental frequency variation (1)
- fungal infection (1)
- fungal infection model (1)
- fungal rhodopsins (1)
- fused thiazaboroles (1)
- future directions (1)
- gRNA-only (1)
- gait disorder (1)
- galactomannan (1)
- galectin-1 (1)
- galectin-3 (1)
- galectin-9 (1)
- gametogenesis (1)
- gastric bypass (1)
- gastrointestinal infections (1)
- gastrointestinal tract (1)
- gaze discrimination (1)
- gaze processing (1)
- gender (1)
- gender differences (1)
- gender influence (1)
- gene (1)
- gene expression (1)
- gene prediction (1)
- gene therapy (1)
- gene × sex interaction (1)
- gene-environment interaction (1)
- general practitioner (1)
- generation effect (1)
- generator of D-norm (1)
- genetic analysis (1)
- genetic architecture (1)
- genetic code expansion (1)
- genetic diversity (1)
- genetic markers (1)
- genetic modification (1)
- genetic risk (1)
- genetic variants (1)
- genetics (1)
- genital warts (1)
- genome packaging (1)
- genome wide (1)
- genomic integrity (1)
- genomic traits (1)
- genotype (1)
- genre (1)
- gentamicin sulfate (1)
- gentamicin-loaded poly (methyl methacrylate) bone cement (1)
- genus Aspergillus (1)
- geoarcheology (1)
- geographic information science (1)
- geometry (1)
- gephyrin (1)
- germanophone (1)
- germination speed (1)
- germline mutation (1)
- giant cell arteritis (1)
- givenness (1)
- glaciers (1)
- glial fibrillary acidic protein (1)
- glioblastoma (1)
- global biomes (1)
- global convergence (1)
- glomerular filtration rate (1)
- glucocorticoid excess (1)
- glucose homeostasis (1)
- glucuronide (1)
- glycine receptor (1)
- glycocalyx (1)
- glycophyte Arabidopsis (1)
- glycoprotein receptor Ib (1)
- glycosphingolipids (1)
- gradient HPLC–UV (1)
- graft survival (1)
- graft versus host disease (1)
- grammar (1)
- grand unified theories (1)
- graviception (1)
- grazing (1)
- greenhouse gases (1)
- grief (1)
- groin hernia (1)
- ground‐penetrating radar (1)
- group 13 (1)
- guanosine (1)
- guanylyl cyclase (1)
- guard cells (1)
- guided bone regeneration (1)
- guided bone regeneration (GBR) (1)
- guided tissue regeneration (1)
- guideline adherence (1)
- guidelines & recommendations (1)
- gut barrier (1)
- gynogenesis (1)
- hACE2 (1)
- hMSC-TERT (1)
- habitat availability (1)
- habitual mandibular position (1)
- haemodialysis (1)
- haemoglobin (1)
- halophyte Thellungiella/Eutrema (1)
- handwriting (1)
- haptic neglect (1)
- harmonic analysis (1)
- harmonization (1)
- harmonization of SPECT/CT imaging (1)
- harness free satellite (1)
- havelock functions (1)
- head and neck (1)
- head and neck cancer (1)
- head and neck squamous cell carcinoma (1)
- head-mounted display (1)
- health care providers (1)
- health care service research (1)
- health economics (1)
- health insurance (1)
- health-related quality of life (HRQoL) (1)
- hearing preservation (1)
- heart failure with mid-range ejection fraction (1)
- heart failure with reduced ejection fraction (1)
- heart transplantation (1)
- heart valve repair (1)
- heart-brain axis (1)
- heating (1)
- heavier pnictogens (1)
- heavy eye (1)
- heavy metals (1)
- helicene (1)
- helicenes (1)
- hemadsorption (1)
- hemangioma (1)
- hematopoietic (1)
- hematopoietic stem cell transplantation (1)
- hemiptera (1)
- hemolytic anemia (1)
- hemorrhagic transformation (1)
- hemostasis, (1)
- hepatitis B core protein (1)
- hepatitis B virus (1)
- hepcidin (1)
- herbivorous beetles (1)
- herbivory (1)
- heritability (1)
- herpes simplex virus (1)
- heterocyclic tetrylenes (1)
- heterogeneous background (1)
- heterozygote (1)
- hetrocyclic tetrylene complexes (1)
- hierarchy (1)
- high myopia (1)
- high performance liquid chromatography (1)
- high resolution population data (1)
- high-dose-rate (HDR) brachytherapy (1)
- high-energy (1)
- high-resolution imaging (1)
- hippocampal (1)
- hippocampus (1)
- histamine (1)
- histologic findings (1)
- histomorphometry (1)
- hole (1)
- home-based-rehabilitation (1)
- homeostasis (1)
- homing (1)
- homochiral dimer (1)
- homocysteine (1)
- honey bee (1)
- honey bees and native bees (1)
- honeybee (1)
- hook complex (1)
- horizontal gene transfer (1)
- host cells (1)
- host defense (1)
- host shutoff (1)
- host specificity (1)
- host–parasitoid interaction (1)
- host–pathogen interaction (1)
- human (1)
- human airway mucosa tissue models (1)
- human behavior (1)
- human behaviour (1)
- human biomonitoring (1)
- human computer interaction (HCI) (1)
- human genomics (1)
- human iPSC-derived mesodermal cells (hiMPCs) (1)
- human induced pluripotent stem cell (hiPSC) (1)
- human mesenchymal stem cell (1)
- human nasal epithelial cells (1)
- human neutrophil elastase (HNE) (1)
- human papillomavirus (1)
- human pathogenic fungi (1)
- human respiratory epithelial cells (1)
- human rights (1)
- human trabecular bone decellularization (1)
- human tracheo-bronchial epithelial cells (1)
- human-artificial intelligence interaction (1)
- human-artificial intelligence interface (1)
- human-centered, human-robot (1)
- humans (1)
- hybrid polymers (1)
- hybridogenesis (1)
- hydraulic reactivity (1)
- hydroamination (1)
- hydroboration (1)
- hydrogel formation (1)
- hydrogen bonding (1)
- hyperactivity disorder (1)
- hypercholesterolemia (1)
- hyperekplexia (1)
- hyperlipidemia (1)
- hyperoxia (1)
- hypersensitivity (1)
- hypothalamic gene expression (1)
- hypoxanthine (1)
- iMP (1)
- iPS cells (1)
- iPSC-CMs (1)
- ice sheet hydrology (1)
- iiron transporter (1)
- ileocecal resection (1)
- image segmentation (1)
- image-guided programming (1)
- imagination (1)
- imaging TTE/TEE (ITTE) (1)
- imaging techniques (1)
- imaging the immune system (1)
- imbalanced regression (1)
- imidazolate (1)
- immersive advertising (1)
- immersive interfaces (1)
- immune check inhibitor (1)
- immune checkpoint blockade (1)
- immune checkpoint inhibitor (ICI) (1)
- immune epitope mapping (1)
- immune evasion (1)
- immune genes (1)
- immune monitoring (1)
- immune organs (1)
- immunity (1)
- immunization (1)
- immunoglobulin G (1)
- immunology (1)
- immunosuppression (1)
- immunotherapies (1)
- impedance aggregometry; WHOLE-BLOOD THROMBOELASTOMETRY; DEFINITION; DISEASE (1)
- impervious surface (1)
- impurity profiling (1)
- in silico analysis (1)
- in vitro (1)
- in vitro Selection (1)
- in vitro cell‐stretch model (1)
- in vitro model (1)
- in vitro modeling (1)
- in vitro selection (1)
- in vivo (1)
- in vivo toxicity (1)
- in-situ hybridization (1)
- in-vivo Micro-Computed Tomography (1)
- inappropriate prescription (1)
- inborn errors of immunity (IEIs) (1)
- incidence (1)
- indirect costs (1)
- individual-based modelling (1)
- individual-based models (1)
- indole-glucosinolates (1)
- induced pluripotent stem cells (1)
- induction regimen (1)
- inebilizumab (1)
- infantile neuronal ceroid lipofuscinosis (1)
- infants with deformational plagiocephaly (DP) (1)
- infection control (1)
- infection spread (1)
- infection surveillance (1)
- infections: pneumonia (1)
- infectious diseases (1)
- infectious diseases management (1)
- infectivity assays (1)
- inferential norming (1)
- inferior colliculus (1)
- inflammaging (1)
- inflammatory neuropathy (1)
- inflection (1)
- informal caregiving (1)
- informed consent (1)
- injury prevention (1)
- innovative surgical methods (1)
- inosine (1)
- inositol hexaphosphate (1)
- inpatient rehabilitation (1)
- inpatients (1)
- insect (1)
- insect brain (1)
- insect decline (1)
- insect standard brain atlas (1)
- insect tracking (1)
- insert (1)
- insights (1)
- instrumentation (1)
- insulin receptor (IR) (1)
- intact plants (1)
- integral (1)
- integral-bateman functions (1)
- integrated circuits (1)
- intellectual disabilities (1)
- intensified treatment (1)
- intensity distribution (1)
- intensity zones (1)
- intensity-modulated radiation therapy (1)
- intention-behavior-gap (1)
- intentional binding (1)
- interaction (1)
- interacts (1)
- intercellular junctions (1)
- intercultural learning and teaching (1)
- interdisciplinary education (1)
- interferometry (1)
- interferon γ (1)
- interferon-free (1)
- interleukin-6 (1)
- interleukin-9 (1)
- international multicenter comparison exercise (1)
- interoception (1)
- interpersonal relationships (1)
- interpolation (1)
- intersystem crossing (1)
- intervention design (1)
- intervention evaluation (1)
- intestinal barrier (1)
- intestinal microbiota (1)
- intestine (1)
- intonation (1)
- intra-individual variability (IIV) (1)
- intracellular bacterial pathogens (1)
- intracellular pathogens (1)
- intraindividual comparison (1)
- intraoperative monitoring (1)
- intravenous immunoglobulins (1)
- invasiveness (1)
- inverse problems (1)
- inverse thermogels (1)
- ion channel (1)
- ion signaling (1)
- ion transport (1)
- ionic liquids (1)
- iowa gambling task (1)
- ipilimumab (1)
- iron dyshomeostasis (1)
- iron in parkinsonism (1)
- iron model (1)
- iron pathology (1)
- irrigation (1)
- ischemia (1)
- ischemia/reperfusion injury (1)
- ischemic penumbra (1)
- island biogeography (1)
- island plant communities (1)
- islet transplantation (1)
- isoelectronic analogues (1)
- isomer (1)
- isomerisation (1)
- isoprene (1)
- iterative shape averaging (1)
- joint aspiration (1)
- joint infection (1)
- joint instability (1)
- journal (1)
- junctions (1)
- juvenile hormone (1)
- juvenile idiopathic arthritis (1)
- keratinocytes (1)
- keratitis (1)
- ketenes (1)
- ketogenic diet (1)
- kidney cancer (1)
- kinase inhibitors (1)
- kinetic chemotaxis equation (1)
- knowledge (1)
- laboratory (1)
- lactation (1)
- lactosylceramide alpha-2,3-sialyltransferase (ST3GAL5) (1)
- land use (1)
- landsat (1)
- landscape heterogeneity (1)
- language acquisition (1)
- lanthanides (1)
- laparoscopic appendectomy (1)
- laparoscopy (1)
- large B-cell lymphoma (1)
- large cell transformation (1)
- large-time behaviour (1)
- large‐scale data (1)
- laryngeal tuberculosis (1)
- laser ranging (1)
- lasso regression (1)
- late thrombectomy (1)
- lateral augmentation (1)
- lateral skull base (1)
- latitude (1)
- latitudinal gradient (1)
- law (1)
- learning (1)
- learning and memory (1)
- learning curve (1)
- learning environments (1)
- learning from text (1)
- leaves (1)
- lectin (1)
- left ventricular ejection fraction (1)
- left ventricular geometric abnormality (1)
- left ventricular geometry (1)
- left ventricular mass (1)
- left ventricular remodeling (1)
- left ventricular thrombusv (1)
- left-ventricular function (1)
- legal order (1)
- leisure time (1)
- lenalidomide-refractory patients (1)
- leptin (1)
- leptin system (1)
- lesion symptom mapping (1)
- lethality rate (1)
- leucocyte count (1)
- leukocytes (1)
- lexicon (1)
- life cycle (1)
- lifestyle (1)
- lifetimes (1)
- ligand-gated ion channels (1)
- light stimuli (1)
- light-induced dimerization (1)
- light-sensitive anion channel (1)
- limiting dilution cloning (1)
- linea alba (1)
- linear discriminant analysis (1)
- linear regression analysis (1)
- lipid bilayer membrane (1)
- lipids (1)
- lipoblastoma (1)
- lipodystrophy (1)
- lipoid pneumonitis (1)
- lipoprotein apheresis (1)
- lipoprotein(a) (1)
- liquid crystal alignment (1)
- liquid chromatography tandem mass spectrometry (LC-MS/MS (1)
- liquid chromatography-mass spectrometry (1)
- liquid chromatography/mass spectrometry (1)
- lithium (1)
- liver impairment (1)
- liver metastasis (1)
- lncRNAs (1)
- load to failure testing (1)
- local control (1)
- locator (1)
- lockdown schooling (1)
- locomotion (1)
- locust habitat (1)
- locust monitoring (1)
- locust outbreak (1)
- locust pest (1)
- long non-coding RNA (1)
- long-term effects (1)
- longitudinal magnetic resonance imaging (1)
- longitudinal studies (1)
- longitudinal study (1)
- loss-of-function (1)
- low back pain (1)
- low carb diet (1)
- low profile (1)
- low-secretion phenotype mutants (1)
- luminescent (1)
- lung (1)
- lung cancer (1)
- lung cell model (1)
- lung fibrosis (1)
- lymph node metastases (1)
- lymph node stromal cells (1)
- lymph node transplantation (1)
- lymph node tuberculosis (1)
- lymphocytes (1)
- lymphoid hyperplasia (1)
- lymphoma (1)
- lysosomal recruitment (1)
- m7G cap (1)
- mRNA cap (1)
- mRNA decapping (1)
- mTOR (1)
- macro moths (1)
- macro- and micro-elements (1)
- macrocycles (1)
- macrophage migration inhibitory factor (MIF) (1)
- magnesium (1)
- magnetic compass (1)
- magnetic fluids (1)
- main group element halides (1)
- malnourishment (1)
- management zones (1)
- mandibular advancement (1)
- mandibular resting position (1)
- mandibular shift (1)
- manganese (1)
- manufacturer (1)
- manufacturing (1)
- map projections (1)
- mapping (1)
- marketing (1)
- masks (1)
- mass cytometry (1)
- mass spectronomy (1)
- masticatory muscles (1)
- masticatory system (1)
- mastocytosis (1)
- match load (1)
- materials testing (1)
- maternal stress (1)
- mathematical biology (1)
- mathematics (1)
- maturation signal (1)
- mavacamten (1)
- meal-concurrent media use (1)
- mean fruit body size (1)
- measles (1)
- measurement (1)
- measures (1)
- measuring democracy (1)
- mechanical activation (1)
- mechanical loading (1)
- mechanical thrombectomy (1)
- mechanisms of persister formation (1)
- mechanistic model (1)
- medaka (1)
- media equation (1)
- media-based (1)
- medial ganglionic eminence (1)
- medial patellofemoral ligament (1)
- medial stabilized (1)
- median and dorsal raphe (1)
- medical analytics (1)
- medical device regulation (1)
- medical device software (1)
- medical education (1)
- meditation (1)
- meiotic prophase (1)
- melatonin (1)
- melt electrowriting (1)
- melt electrofibrillation (1)
- melt electrospinning writing (1)
- membrane anchor (1)
- membrane depolarization (1)
- membrane fission (1)
- membrane recycling (1)
- membrane remodeling (1)
- membrane trafficking (1)
- men (1)
- meninges (1)
- menopause (1)
- menstrual cycles (1)
- mental health (1)
- mental health monitoring (1)
- mental illness (1)
- mental rotation (1)
- mentalizing (1)
- mercapturic acid (1)
- merocyanine dyes/pigments (1)
- mesencephalic locomotor region (1)
- mesenchymal markers (1)
- mesenteric lymph node (1)
- mesophyll (1)
- metaanalysis (1)
- metabolic glycoengineering (1)
- metabolic modeling (1)
- metabolome (1)
- metabolomic profiling (1)
- metabolomics (1)
- metadynamics (1)
- metagenomics (1)
- metal-metal interactions (1)
- metallacycles (1)
- metallomacrocycles (1)
- metamorphic buffer layer (1)
- metamorphic sulfidation (1)
- metastasis (1)
- metastasis-directed therapy (1)
- metathesis (1)
- methyl exchange (1)
- methylation (1)
- methylphenidate (1)
- miR-182-5p (1)
- miR-183 cluster (1)
- miRNA (1)
- micelles (1)
- microanastomosis (1)
- microbes (1)
- microbial community abundance and compositions (1)
- microbial rhodopsins (1)
- microbiology (1)
- microbiology techniques (1)
- microbiome (1)
- microbiome metabarcoding (1)
- microfibers (1)
- microfluidics (1)
- microhabitats (1)
- microphase separation (1)
- microsaccade direction (1)
- microsaccade rate (1)
- microtubule cytoskeleton (1)
- microvasculature (1)
- mid quantiles (1)
- mid-latitude cyclone (1)
- middle aged (1)
- middle cerebral artery occlusion (1)
- middle voice (1)
- midline frontal theta band frequency activation (1)
- migration (1)
- mimetic peptide (1)
- mind-body intervention (1)
- mindfulness (1)
- mind–body intervention (1)
- minimal self (1)
- minimum reporting standards (1)
- mitochondrial DNA (1)
- mitogen-activated protein kinase (1)
- mitotane (1)
- mixed methods (1)
- mixed reality (1)
- mixed-cultural settings (1)
- mixed-species forestry (1)
- mobile application (1)
- mobile crowdsensing (1)
- mobile health (1)
- mobile networks (1)
- model (1)
- model complexity (1)
- modified Rodnan skin score (mRSS) (1)
- modified monosaccharides (1)
- modular tumor tissue models (1)
- modulation (1)
- modulatory effects (1)
- mold exposure (1)
- molecular alterations (1)
- molecular conformation (1)
- molecular diagnostics (1)
- molecular docking (1)
- molecular dynamics simulation (1)
- molecular evolution (1)
- molecular modeling (1)
- molecular modelling (1)
- molecular radiotherapy (MRT) (1)
- monoclonal antibody (1)
- monoclonal stable cell (1)
- monolayer (1)
- moon (1)
- morbidity (1)
- more-individuals hypothesis (1)
- morning recovery (1)
- morphological features (1)
- morphology controls (1)
- morphometry (1)
- mortality/survival (1)
- mossy fiber synapses (1)
- motile behaviour (1)
- motor learning (1)
- motor skill learning (1)
- motor training (1)
- movement ecology (1)
- movement interaction (1)
- moving rubber-hand illusion (1)
- mtDNA (1)
- multi-messenger (1)
- multicenter study (1)
- multilayered vessel wall with intimate, media and adventitia (1)
- multilevel luminescence identification (1)
- multimodal (1)
- multimodal narratives (1)
- multimodal therapy (1)
- multimodal treatments (1)
- multiparametric CT (1)
- multiple bonds (1)
- multiple system atrophy (1)
- multiscale modeling (1)
- multisensory integration (1)
- multispecies studies (1)
- multivariate exceedance (1)
- multivariate extreme value theory (1)
- multivariate max-domain of attraction (1)
- multi‐organ disease (1)
- muscle cuff (1)
- muscle dislocation (1)
- muscle-invasive bladder cancer (1)
- musculoskeletal diseases (1)
- musculoskeletal system (1)
- mushroom bodies (1)
- mushroom body (1)
- mushroom body calyx (1)
- music (1)
- musical stereotypes (1)
- mutation screening (1)
- mutation triggers (1)
- mutations (1)
- mutualism (1)
- myasthenia (1)
- mycosis fungoides (1)
- mycotoxin (1)
- myelin (1)
- myeloid (1)
- myeloid cells (1)
- myeloid-derived suppressor cells (MDSCs) (1)
- myeloma (1)
- myocardial aging (1)
- myocardial perfusion (1)
- myocardial work (1)
- myocardial work efficiency (1)
- myocarditis (1)
- myofilament proteins (1)
- myosin (1)
- naive T-cell gene editing (1)
- nano CT (1)
- nanocarrier (1)
- nanoparticle aggregation (1)
- nanoparticles (1)
- nanorods and nanosheets (1)
- nanotube formation (1)
- nanovesicle formation (1)
- naphthyridine (1)
- narrative text (1)
- narrative texts (1)
- narrow bandwidth (1)
- nasal polyps (1)
- natamycin (1)
- national parks (1)
- natriuretic peptide (1)
- natural enemies (1)
- natural enemy (1)
- natural environment (1)
- natural products (1)
- naturalized species (1)
- navigation (1)
- ncuCyte\(^®\)S3 (1)
- near surface multidimensional geophysics (1)
- near-infrared sensitivity (1)
- near-surface soil moisture (1)
- negative affect (1)
- negative pressure wound therapy (1)
- neoclassical growth model (1)
- nephroblastoma (1)
- nephroblastomatosis (1)
- nephrology (1)
- nerve biopsy (1)
- nerve tumor (1)
- nervous system (1)
- nesting ecology (1)
- netrin-1 (1)
- network biology (1)
- network meta-analysis (1)
- network pharmacology (1)
- neural progenitor cells (1)
- neuralgic amyotrophy (1)
- neurite growth (1)
- neuroblast growth (1)
- neurocritical care (1)
- neurodevelopment (1)
- neurodevelopmental disorders / genetics (1)
- neuroendocrine neoplasms (NEN) (1)
- neuroendocrine tumor (1)
- neuroendocrine tumor (NET) (1)
- neuroendocrine tumors (NET) (1)
- neurofibromatosis type 2 (1)
- neuroleukemiosis (1)
- neurological complications (1)
- neurological examination (1)
- neuromelanin (1)
- neuromodulation (1)
- neuromyelitis optica spectrum disorders (1)
- neuronal electrodes (1)
- neuronal maturation (1)
- neuronal networks (1)
- neuronal oscillations (1)
- neuropathic pain (1)
- neuropathology (1)
- neuropathy (1)
- neuropeptidomics (1)
- neuropils (1)
- neuroprotective pathways (1)
- neuroprotectivity (1)
- neuropsychiatric disorders (1)
- neuroradiology (1)
- neurorehabilitation (1)
- neurosphere (1)
- neurospheres (1)
- neurotoxicity (1)
- neurotransmitter (1)
- neurotrophic factors (1)
- neurovascular disorders (1)
- neutral theory (1)
- neutrophil transmigration (1)
- newborn infants (1)
- newly diagnosed ITP (1)
- next generation sequencing (1)
- nexus (1)
- niche partitioning (1)
- nickel complexes (1)
- nitrate and thyroid carcinogenesis (1)
- nitric oxide (1)
- nitrogen heterocycles (1)
- nitrogen trichloride (1)
- nivolumab (1)
- nociception (1)
- nodular lymphcyte (1)
- noise measurement (1)
- nomes (1)
- nomogram (1)
- non-contact´ (1)
- non-coordinate anionic ligand (1)
- non-radiative decay (1)
- non-small cell lung cancer (1)
- non-smooth and non-convex optimization (1)
- noncoding RNA (1)
- nondestructive testing (1)
- nondocing RNA (1)
- nonverbal behavior (1)
- non‐classical crystallization (1)
- norepinephrine transporter (1)
- normal adrenal glands (1)
- novel disturbance (1)
- nuclear medicine (1)
- nuclear medicine therapy (1)
- nuclear ribonucleoprotein-R (1)
- nucleic acid (1)
- nucleolus (1)
- nucleophile (1)
- nucleotide excision repair (1)
- numerical analysis (1)
- nursing (1)
- nutrient supplementation (1)
- nutrients (1)
- nutrition (1)
- nutritional status (1)
- object recognition memory (1)
- object-oriented actions (1)
- objective structured clinical examination (1)
- ochratoxin A (1)
- octogenarians (1)
- octopamine (1)
- octree (1)
- off label use (1)
- oil bees (1)
- old patients (1)
- older adult (1)
- older adults (1)
- olecranon (1)
- olfactory learning (1)
- oligmometastases (1)
- oligomerization (1)
- oligorecurrence (1)
- olive (1)
- omecamtiv mecarbil (1)
- ontogeny (1)
- ontology (1)
- open appendectomy (1)
- open science (1)
- open wound treatment (1)
- open-source epidermis (1)
- operative (1)
- operative Verjüngung (1)
- oppositional-defiant disorder (1)
- optic lobes (1)
- optical remote sensing (1)
- optical spectroscopy (1)
- oral anticancer drugs (1)
- oral potentially malignant disorders (1)
- organ toxicity (1)
- organic semiconductors (1)
- organic amendment (1)
- organic electronics (1)
- organic light emitting diodes (1)
- organic light-emitting diodes (1)
- organoboron (1)
- organoid (1)
- oriented attachment (1)
- orthodontic forced eruption (1)
- orthopaedics (1)
- osimertinib (1)
- osseointegration (1)
- osteoarthritis (1)
- osteoclasts (1)
- osteogenesis (1)
- ostracism (1)
- otology (1)
- outcomes (1)
- outpatient (1)
- outpatients (1)
- overdenture (1)
- overstory (1)
- overview (1)
- owls (1)
- owner-operated retailers (1)
- oxidized phospholipids (1)
- ozone (1)
- pCa (1)
- pH (1)
- paediatric cancer (1)
- paediatrics (1)
- pain (1)
- pain therapy (1)
- painted nest preference (1)
- palaeontology (1)
- paleoclimate (1)
- paleoenvironment (1)
- palladium-catalyzed (1)
- palsa development (1)
- pan (1)
- pan-RCC (1)
- pancreatic head cancer (1)
- pandemic (1)
- pandemic crisis (1)
- panel sequencing (1)
- parabiosis (1)
- parallel evolution (1)
- parallel polar dimers (1)
- parasite evolution (1)
- parasite genetics (1)
- parasocial relationship (1)
- parathyroid carcinoma (1)
- parent-child interaction therapy (PCIT) (1)
- parietal alpha band frequency activation (1)
- parkinson’s disease (1)
- park–people relationships (1)
- parotid gland (1)
- parthenogenesis (1)
- particle study (1)
- passage comprehension (1)
- passivation (1)
- passive (1)
- passive data (1)
- passive haptic feedback (1)
- patch clamp recording (1)
- patella alta (1)
- patella dislocation (1)
- patella instability (1)
- pathogenesis (1)
- pathogenicity (1)
- pathological staging (1)
- pathology (1)
- pathophysiology (1)
- patient blood management (1)
- patient outcome (1)
- patient specific implant (1)
- patient survival (1)
- patient triage (1)
- patient-derived organoid (PDOs) (1)
- patient-derived tumor organoid (PDTO) (1)
- patients with multiple myeloma (1)
- pediatric adrenocortical adenoma (1)
- pediatric adrenocortical cancer (1)
- pediatric adrenocortical tumor (1)
- pediatric immune thrombocytopenia (1)
- pediatric stem cell transplantation (1)
- pediatric thyroid cancer after Chernobyl and Fukushima (1)
- pediatrician (1)
- pelvic discontinuity (1)
- pembrolizumab (1)
- pemphigus (1)
- pen and paper vs. computer role-players (1)
- peptide (1)
- peptide immobilization (1)
- peptide inhibitor of envelopment (1)
- peptide microarray (1)
- peptide tyrosine tyrosine (PYY) (1)
- peptide tyrosine tyrosine 3-36 (PYY3-36) (1)
- percentile estimation (1)
- percutaneous valve therapy (PVT) (1)
- performance analysis (1)
- perfusion bioreactor (1)
- perfusion-based bioreactor system (1)
- pericyclic reaction (1)
- period (1)
- periodontitis (1)
- perioperative care (1)
- perioperative management (1)
- peripheral artery disease (1)
- peripheral nervous system (1)
- peripheral neuropathy (1)
- periphrastic forms (1)
- periprosthetic joint infection (1)
- perivesical extension (1)
- permafrost hydrology (1)
- permeability (1)
- perovskite solar cells (1)
- peroxisomes (1)
- persistence (1)
- personality (1)
- personality faceaurus (1)
- personalized antimicrobial therapy (1)
- personalized medicine (1)
- perylenebisimide dyes (1)
- pests (1)
- phage (1)
- phantom (1)
- pharmaceutical analysis (1)
- pharmacoepidemiology (1)
- pharmacogenomics (1)
- phase conversion (1)
- phase transition (1)
- phenological escape (1)
- phenomenology (1)
- phenomenology of New Physics (1)
- phenprocoumon (1)
- phenylboronate (1)
- phosphinidenes (1)
- phosphoranes (1)
- phosphorescence (1)
- phosphorus (1)
- phosphorus heterocycles (1)
- photo-cross-linking (1)
- photoelectron spectroscopy (1)
- photolysis (1)
- photonic structure (1)
- photoperiodism (1)
- photopharmacology (1)
- photoreceptor (1)
- photorespiration (1)
- photosenitizers (1)
- photosynthesis (1)
- phototaxis (1)
- photothrombotic stroke (1)
- phthalocyanines (1)
- phylogenetic analysis (1)
- physical functioning (1)
- physical hydrogels (1)
- physical performance (1)
- physiologically based pharmacokinetic (PBPK) modeling (1)
- physiology (1)
- phytic acid (1)
- phytochemicals (1)
- phytophagous beetles (1)
- pigmentation (1)
- piicture comprehension (1)
- pincer ligand (1)
- pingos (1)
- piperacillin/tazobactam (1)
- place-illusion (1)
- plant defence (1)
- plant ecology (1)
- plant functional traits (1)
- plant growth (1)
- plant invasion (1)
- plants (1)
- plant–pollinator interaction (1)
- plaque (1)
- plaque assay (1)
- plaque characteristics (1)
- plaque isolation (1)
- plasma cell disorder (1)
- plasma cells (1)
- plasma membrane (1)
- plasma physics (1)
- plasmid-chromosome crosstalk (1)
- plate (1)
- platelet (1)
- platelet factor 4 (1)
- platelet receptors (1)
- platform (1)
- plausibility-illusion (1)
- pleasant anticipation (1)
- pnictogen coupling (1)
- pocket factor (1)
- point cloud compression (1)
- point cloud registration (1)
- point of care testing (1)
- point-to-plane measure (1)
- point-to-point measure (1)
- pointing gestures (1)
- pointing production and interpretation (1)
- polariton condensation (1)
- polarized training (1)
- polaron delocalization (1)
- policy (1)
- pollen limitation (1)
- pollen metabarcoding (1)
- pollinator (1)
- poly(2- oxazoline) (1)
- poly(2-ethyl-2-oxazoline) (1)
- poly(2-oxazine) (1)
- polyadenylation (1)
- polycycles (1)
- polymer drug interaction (1)
- polymer matrix (1)
- polymeric matrix (1)
- polymers (1)
- polymicrobial infection (1)
- polymyalgia rheumatica (1)
- polyoxazolines (1)
- polyurethane (1)
- pomalidomide (1)
- ponds (1)
- population change (1)
- population coverage (1)
- population divergence (1)
- population oscillations (1)
- porin (1)
- porousmaterials (1)
- porphyrins (1)
- positionalskull deformities (1)
- positive selection (1)
- positron emission tomography/computed tomography (1)
- post mortem biochemistry (1)
- post-operative antibiotic treatment (1)
- post-traumatic stress disorder (1)
- postencephalitic parkinsonism (1)
- posterior component separation (1)
- postmortem biochemistry (1)
- potassium channel (1)
- potassium reagent (1)
- pouch (1)
- power grids (1)
- pre-analytical variation (1)
- precision agriculture (1)
- preclinical imaging (1)
- preclinical research (1)
- preconditioning (1)
- precursor symptoms (1)
- prediction interval (1)
- prematurity (1)
- preoperative localization (1)
- presynaptic plasticity (1)
- preterm (1)
- preterm birth (1)
- prevalence (1)
- preventive treatment (1)
- primary biliary cholangitis (1)
- primary healthcare (1)
- primary immunodeficiency (1)
- primary progressive aphasia (1)
- primary ventral hernia (1)
- primär ventrale Hernie (1)
- principal component analysis (1)
- printability (1)
- pro-inflammatory cytokines (1)
- pro-oxidant (1)
- probes (1)
- proboscis extension response (1)
- professional (1)
- progenitor (1)
- prognosis (1)
- prognostic biomarker (1)
- prognostic factors (1)
- progression (1)
- proliferation (1)
- prolonged cytopenia (1)
- prolonged survival (1)
- promoter-proximal pausing (1)
- propagule pressure (1)
- prospective studies (1)
- prostate Imaging Reporting and Data System (1)
- prostate-specific membrane antigen (1)
- prostate-specific membrane antigen (PSMA) (1)
- prostheses and implants (1)
- protease inhibitors (1)
- protein crowding (1)
- protein kinase D2/PKD2/PRKD2 (1)
- protein kinases (1)
- protein purification (1)
- protein-DNA interaction (1)
- proteomics (1)
- proteomics analysis (1)
- proton channel (1)
- protozoan (1)
- proximal gradient method (1)
- pseudofracture (1)
- pseudolymphoma (1)
- psychiatric disorders (1)
- psycho-geriatrics (1)
- psychological distress (1)
- psychological interventions (1)
- psychological support (1)
- psychological variables (1)
- psychophyisology (1)
- public mental health (1)
- pulmonary arteries (1)
- pulmonary edema (1)
- pulmonary rehabilitation (1)
- pupil diameter (1)
- pupil dilation (1)
- purmorphamine (1)
- pyrazolo[3,4-d]pyrimidine (1)
- pyrenes (1)
- pyridinium (1)
- qPCR (1)
- quality control (1)
- quality indicators (1)
- quality of democracy (1)
- quality of experience prediction (1)
- quality of life (QoL) (1)
- quality of live (1)
- quantification (1)
- quantitative SPECT/CT (1)
- quantum dots (1)
- quasinormality constraint qualification (1)
- qubits (1)
- questionnaire (1)
- quinoa (1)
- racemization (1)
- radial (1)
- radiation therapy (1)
- radical coupling (1)
- radical resection (1)
- radical species (1)
- radiculopathy (1)
- radiobiology (1)
- radiography (1)
- radioligand therapy (1)
- radionuclide therapy (1)
- radiopharmaceuticals (1)
- radiotherapy (1)
- radiotracers (1)
- rainfall gradient (1)
- rainfall response (1)
- raman spectroscopy (1)
- random forest classification (1)
- randomized controlled double-blind study (1)
- randomized controlled trial (1)
- rapid evolution (1)
- rare earth doped nanoparticles (1)
- rare mendelian disorders (1)
- ravulizumab (1)
- reaction mechanism (1)
- reaction mechanisms (1)
- reactive aggression (1)
- reactive oxygen species (ROS) (1)
- reactive virtual agents (1)
- reading (1)
- reading comprehension (1)
- reading skills (1)
- real-time NMR spectroscopy (1)
- real-time PCR (1)
- realism (1)
- reality (1)
- recall antigen (1)
- receptor cluster (1)
- recommender system (1)
- reconstruction (1)
- recovery (1)
- rectum (1)
- recurrence free survival (1)
- recurrence-free survival (1)
- red lists (1)
- redox chemistry (1)
- redox processes (1)
- redox-active ligands (1)
- reduction (1)
- refugee healthcare (1)
- regenerative capacity (1)
- regime (1)
- regime shift (1)
- regional resilience (1)
- regionalization and organoids (1)
- regression-based norming (1)
- regulation (1)
- regulation of gene expression (1)
- rejection (1)
- relaxation method (1)
- release (1)
- reliability (1)
- remdesivir (1)
- reminder e-mails (1)
- remote sensing‐enabled essential biodiversity variables (1)
- renal (1)
- renal artery (1)
- renal cell carcinoma (1)
- renal failure (1)
- renal function (1)
- renewable fuels (1)
- repair (1)
- repeat surgery (1)
- repeated surgery (1)
- replica-exchange molecular dynamics (1)
- replication (1)
- replication studies (1)
- reporting and data system (1)
- repression (1)
- reproductive health (1)
- repulsive guidance molecule A (1)
- research methods (1)
- research software engineering (1)
- residential institutions (1)
- resilience (1)
- resistance (1)
- response (1)
- retail (1)
- retention interval (1)
- retinitis pigmentosa (1)
- retinoic acid (1)
- retromuscular mesh (1)
- retroperitoneal tumor (1)
- retrorectus mesh (1)
- retrotransposons (1)
- retroviral vectors (1)
- reveals (1)
- revenge (1)
- review (1)
- revision hip (1)
- revisional surgery (1)
- rheumatoid arthritis (1)
- rhinitis (1)
- ribosome biogenesis (1)
- riboswitch (1)
- right heart impairment (1)
- right ventricular dysfunction (1)
- rising incidence of thyroid cancer (1)
- risk (1)
- risk factors (1)
- risk factors and etiology (1)
- risk management (1)
- risk of fall (1)
- risk stratification (1)
- risk factor analysis (1)
- ritual (1)
- robotic surgical procedures (1)
- robustness checks (1)
- rocus sieberi (1)
- root infection systems (1)
- root pathogens (1)
- root resorption (1)
- rotator cuff tear (1)
- rumenic acid (1)
- rural tourism (1)
- ruthenium (1)
- ruthenium catalysts (1)
- rygb (1)
- s-block metals (1)
- sacred lakes (1)
- sacrificial printing (1)
- safety (1)
- safety behavior (1)
- salinity (1)
- salivary (1)
- salivary glands (1)
- sample size calculation (1)
- sample weighting (1)
- saprobic and ectomycorrhizal basidiomycetes (1)
- saproxylic beetles (1)
- sarcopenia (1)
- satellite remote sensing (1)
- satellite technology (1)
- satisfaction with life (1)
- satralizumab (1)
- scPDSI (1)
- scaffold search (1)
- scenario analysis (1)
- sciatic nerve (1)
- scientific publications (1)
- scleroderma (1)
- score (1)
- screening (1)
- screening and overdiagnosis (1)
- second hit (1)
- second line therapy (1)
- secondary data usage (1)
- secondary skin closure (1)
- secretion (1)
- security tags (1)
- sedentary behavior (1)
- sedimentology (1)
- seed dispersal strategy (1)
- selective outcome reporting (1)
- selen (1)
- self-assembly (1)
- self-construction (1)
- self-employed (1)
- self-governance (1)
- self-help (1)
- self-navigation (1)
- self-organisation (1)
- self-supervised learning (1)
- semantic differential (1)
- semantic segmentation (1)
- seminoma (1)
- senescence (1)
- sense of agency (1)
- sense of ownership (1)
- sensitivity (1)
- sensitivity analysis (1)
- sensorimotor rhythm (1)
- sensory processing (1)
- sentinel (1)
- separation (1)
- separation techniques (1)
- sepsis (1)
- sequential optimality condition (1)
- serial block face EM (1)
- serious games (1)
- seroepidemiologic studies (1)
- seroma (1)
- serotonin transporter deficient mice (1)
- serotonin-specific neurons (1)
- serum concentration (1)
- sesnsors (1)
- severe injury (1)
- sex determination (1)
- shape fidelity (1)
- shear stress (1)
- shear thinning (1)
- shimming (1)
- shoot–root interaction (1)
- short‐rotation coppice (1)
- shrub‐cover (1)
- sialic acid (1)
- sialyltransferase (1)
- signaling pathway (1)
- signs and symptoms (1)
- silkworm (1)
- silver (1)
- simulated intestinal fluid (1)
- simulation (1)
- simultaneous integrated boost (1)
- single molecule localization microscopy (1)
- single strand blocking (1)
- single-molecule biophysics (1)
- single-molecule fluorescence spectroscopy (1)
- single-photon emitter (1)
- single-photon source (1)
- single-sided deafness (1)
- singlet (1)
- singlet oxygen (1)
- sisomicin (1)
- site-specific RNA cleavage (1)
- skeletal mechanobiology (1)
- sketching (1)
- skin biopsy (1)
- skin carcinogenesis (1)
- skin models (1)
- skin punch biopsy (1)
- skinned fiber (1)
- sky compass (1)
- sleep (1)
- sleeping sickness (1)
- slope (1)
- small RNAs (1)
- small business (1)
- small fiber neuropathy (1)
- smart speaker (1)
- smartphone communication (1)
- smoking cessation (1)
- snow hydrology (1)
- snow parameters (1)
- snow variability (1)
- snowmelt runoff model (1)
- social attention (1)
- social cognitive (1)
- social decision-making (1)
- social exclusion (1)
- social gaze (1)
- social insect (1)
- social insects (1)
- social interaction (1)
- social media use (1)
- social self‐sorting (1)
- social understanding (1)
- social well-being (1)
- socioeconomic status (1)
- soft tissue augmentation (1)
- software complexity (1)
- software development (1)
- soil characteristics (1)
- soil matric potential (1)
- soil-borne microorganisms (1)
- solnatide (1)
- solubility (1)
- soluble guanylyl cyclase (1)
- soluble-RNA (1)
- solution electrospinning (1)
- solvent effects (1)
- somatostatin receptor (1)
- somatostatin receptor (SSTR) (1)
- southern annular mode (1)
- space–terrestrial networks (1)
- spacing effect (1)
- spanlastic (1)
- sparse control problems (1)
- spatial navigation (1)
- spatial water balance (1)
- spatiotemporal thrombus (1)
- specialists (1)
- specialization (1)
- species as individuals (1)
- species as natural kinds (1)
- species coexistence mechanism (1)
- species concept (1)
- species diversity (1)
- species invasions (1)
- species problem (1)
- speech discrimination (1)
- spell (1)
- spermatogenesis (1)
- spermatogenic cell sorting (1)
- spherical (1)
- spheroids (1)
- sphingolipid (1)
- sphingomyelinase (1)
- sphingomyelinase release (1)
- sphingosine 1-phosphate (1)
- sphingosine-1-phosphate (1)
- spin (1)
- spinal cord (1)
- spinal cord neurons (1)
- spinal tumor operation (1)
- spiral ganglion neuron (1)
- spironolactone (1)
- spleen (1)
- splicing (1)
- split-belt treadmill (1)
- spondylodysplastic Ehlers-Danlos syndrome (1)
- spontaneous eye blink (1)
- spring flood (1)
- squamous (1)
- standardization of SPECT/CT imaging (1)
- standing variation (1)
- stanfieldite (1)
- staphylococcal alpha-toxin (1)
- startle disease (1)
- state (1)
- stationarity (1)
- statistical methods (1)
- statistical validity (1)
- stealth fluorophores (1)
- stem cells (1)
- stem-cell research (1)
- stereotactic body radiotherapy (1)
- stereotaxy (1)
- stereotype accuracy (1)
- stomatal conductance (1)
- storage volume (1)
- strabismus fixus (1)
- strain specificity (1)
- stream flow (1)
- stress conditions (1)
- stress signaling (1)
- structural MRI (1)
- structural battery (1)
- structural synaptic plasticity (1)
- structure-activity relationships (1)
- structure–activity (1)
- structure–function relation (1)
- sturgeon (1)
- stylus (1)
- subarachnoid hemorrhage (SAH) (1)
- subgingival defects (1)
- subjective perception (1)
- subphthalocyanine (1)
- subpixel (1)
- subscapularis tear (1)
- subsidence (1)
- substantia nigra (1)
- substituent (1)
- subthalamic nucleus (1)
- subungual (1)
- sucrose responsiveness (1)
- sudden cardiac death (1)
- suffering (1)
- sugar glass printing (1)
- sulfate (1)
- sulfide inclusions (1)
- super-resolution (1)
- super-resolution microscopy (SRM) (1)
- superparamagnetism (1)
- superstructure (1)
- supersymmetry (1)
- supervised learning (1)
- supplements (1)
- supportive care (1)
- supraglacial lakes (1)
- supramolecular assembly (1)
- supramolecular folding (1)
- supramolecular polymers (1)
- supraparticles (1)
- surface modification (1)
- surface potential recording (1)
- surgical (1)
- surgical and invasive medical procedures (1)
- surgical antimicrobial prophylaxis (1)
- surgical complications (1)
- surgical intra-abdominal infections (1)
- surgical oncology (1)
- surgical outcome (1)
- surgical procedures (1)
- surgical therapy (1)
- surveillance (1)
- survival (1)
- survivors (1)
- sustainability (1)
- sustainable intensification (1)
- sustained inflammation (1)
- sutures (1)
- swine (1)
- symbiont selection (1)
- sympathetic nervous system (1)
- symptom-specific treatment (1)
- synapse formation (1)
- synaptic complexes (1)
- synaptic plasticity (1)
- synbones (1)
- synchrotron radiation (1)
- synovial fluid (1)
- synthesis (1)
- synthetic pathways (1)
- system architecture design (1)
- system simulation (1)
- systematic investigations (1)
- systematic literature review (1)
- systematic review, (1)
- systemic endotoxemia (1)
- systems biology (1)
- tachykinin (1)
- tacrine (1)
- tail conditional expectation (1)
- tandem mass spectrometry (1)
- target considerations (1)
- targeted metabolomics (1)
- targeted therapy (1)
- task retention (1)
- tauopathy (1)
- teacher assessments (1)
- teacher education (1)
- technological growth (1)
- tele-medicine (1)
- telemedicine (1)
- telomeres (1)
- temperature (1)
- template catalysis (1)
- temporal binding (1)
- temporal bone (1)
- temporal mismatch (1)
- temporal processing (1)
- term patterns (1)
- terminal ileitis (1)
- terrain parameters (1)
- testing strategy (1)
- tetracene dimer (1)
- tetrahydroisoquinoline derivates (1)
- tetramers (1)
- text mining (1)
- textile sector (1)
- thaw (1)
- theory of mind (1)
- therapeutic antibody (1)
- thermogelling (1)
- thermogenesis (1)
- thermokarst (1)
- thermoresponsive hydrogel (1)
- thin-layer chromatography (1)
- thiophene (1)
- third-wave psychotherapy (1)
- thoracic cancer (1)
- thorax (1)
- thoughts of a planned leisure activity (1)
- threat (1)
- three-dimensional (1)
- threecoordinate boron (1)
- threshold criterion (1)
- threshold level (1)
- thrombin (1)
- thrombocyte (1)
- thromboelastometry (1)
- thromboemboli (1)
- thromboembolism (1)
- thromboinflammation (1)
- thromboxane (1)
- thymic epithelial tumor (1)
- thymitis (1)
- thymus (1)
- tibial head depression fracture (1)
- tics (1)
- tight junction proteins (1)
- time lapse cameras (1)
- time perception (1)
- time series analysis (1)
- time since loss (1)
- time-resolved spectroscopy (1)
- time-series (1)
- time-to-centrifugation (1)
- time‐varying delay (1)
- tissue model (1)
- titanium (1)
- tocilizumab (1)
- toe (1)
- tolerability (1)
- tools (1)
- tooth fracture (1)
- tooth injuries (1)
- topic modeling (1)
- topological insulators (1)
- topotaxis (1)
- total internal reflection microscopy (1)
- trabectome (1)
- trabeculectomy (1)
- trace elements (1)
- traceability of SPECT/CT imaging (1)
- tracheal cytotoxin (1)
- trade‐offs (1)
- trained immunity (1)
- training (1)
- training sample migration (1)
- trait anxiety (1)
- tranexamic acid (1)
- transanal endoscopic microsurgery (TEM) (1)
- transcatheter valveimplantation (TVI) (1)
- transcranial motor-evoked potentials (1)
- transcriptome (1)
- transcutaneous auricular vagus nerve stimulation (1)
- transcutaneous cervical vagus nerve stimulation (1)
- transcutaneous vagus nerve stimulation (1)
- transfer learning (1)
- transformations (1)
- transgenic animals (1)
- transient absorption (1)
- transient ischemic attack (1)
- transition metal complexes (1)
- transition metal-free (1)
- translational neuroscience (1)
- transmission (1)
- transplantation (1)
- transportation (1)
- transporter gene SLC2A3 (1)
- transposable elements (1)
- transthyretin (1)
- transverse fascia (1)
- traumatic brain injury (1)
- treatment guidelines (1)
- treatment options (1)
- treatment resistance (1)
- treatment response (1)
- treatment-induced neuropathy in diabetes (TIND) (1)
- tree architecture (1)
- tree growth (1)
- tree structure (1)
- tremor (1)
- triacylglycerols (1)
- trial registration (1)
- triangular fibrocartilage (1)
- triarylborane (1)
- triglycerides (1)
- trinuclear (1)
- triplets (1)
- trochlear dysplasia (1)
- troponin (1)
- trust (1)
- trust game (1)
- trustworthiness (1)
- tryptophan (1)
- tsetse fly (1)
- tumor disease (1)
- tumor invasion front (1)
- tumor spheroids (1)
- tumor surveillance (1)
- tumor-vessel wall-interface model (1)
- tumors (1)
- tumour immunology (1)
- tunable ultra‐thin biphasic membrane (1)
- type of death (1)
- tyramine (1)
- tyrosine kinase inhibitor (TKI) (1)
- tyrosine kinase inhibitors (1)
- uORF (1)
- ublituximab (1)
- ultimatum game (1)
- ultrahigh field (1)
- ultrahigh-field (1)
- ultrasound vocalizations (1)
- umbilical hernia (1)
- umbrella-shaped mesogens (1)
- uncoupling protein 1 (1)
- understory (1)
- unidirectional freezing (1)
- unmet needs (1)
- unobservable contracts (1)
- unsupervised clustering (1)
- upper extremity (1)
- upstream competition (1)
- urban greening (1)
- urinary tract infections (1)
- urology (1)
- ursodeoxycholic acid (1)
- usability evaluation (1)
- use cases (1)
- user experience (1)
- user interaction (1)
- user study (1)
- uveal melanoma (1)
- vaccination (1)
- vaccination campaign (1)
- vaccination hesitancy (1)
- vaccine (1)
- vaccine refusal (1)
- vacuolar membrane (1)
- value at risk (1)
- variability (1)
- variant surface glycoproteins (1)
- various cancer diseases (1)
- vascular (1)
- vascular biofabrication (1)
- vascular disease (1)
- vascular disturbances (1)
- vascular network and hierarchical organized vessels (1)
- vascular wall stem and progenitor cells (1)
- vascularization model (1)
- vasculature (1)
- vasculitis (1)
- vasculogenesis (1)
- vegetation response (1)
- velocity jump process (1)
- velocity-dependent collision frequency (1)
- venereology (1)
- ventilatory threshold (1)
- ventral hernia (1)
- ventricular assist device (1)
- verbal behaviour (1)
- vertical mismatch (1)
- vestibular schwannoma (1)
- veterinarians (1)
- veterinary medicine (1)
- viologens (1)
- viral (1)
- viral assembly (1)
- viral epidemiology (1)
- virology (1)
- virtual agent (1)
- virtual audience (1)
- virtual body ownership (1)
- virtual environments (1)
- virtual humans (1)
- virtual training (1)
- virtual-reality-continuum (1)
- virulence (1)
- virus (1)
- virus budding (1)
- virus entry (1)
- virus host interaction (1)
- virus replication (1)
- viruses (1)
- virus–iron interaction (1)
- visual analytics (1)
- visual perception (1)
- vitamin D (1)
- vitamin D deficiency (1)
- vocal responses (1)
- voice assistant (1)
- voice-based artificial intelligence (1)
- volatile anesthetics (1)
- voltage clamp (1)
- volumetric absorptive microsampling (1)
- vomiting (1)
- von Economo (1)
- water retention (1)
- water sports (1)
- water yield (1)
- wave interference (1)
- waveguides (1)
- weak intermolecular coordination (1)
- weakly coordinating anions (1)
- weight gain (1)
- wetland (1)
- wheat yield (1)
- whole blood ex vivo model (1)
- whole breast irradiation (1)
- whole-genome analysis (1)
- wind compass (1)
- winter wheat (1)
- wireless communication (1)
- wireless-bus (1)
- wood production (1)
- word recognition (1)
- work engagement (1)
- working hours (1)
- working memory (1)
- wound fluid (1)
- wound model (1)
- wound physiology (1)
- wrist (1)
- yoga (1)
- young patients (1)
- yvcK/glmR operon (1)
- z-score (1)
- zeta-functions (1)
- zinc (1)
- zinc cluster transcription factor (1)
- zinc oxide nanoparticles (1)
- ɑ-Synuclein and iron (1)
- ΔNp63 (1)
- α-Emitter (1)
- α-tricalcium phosphate (1)
- β-catenin (1)
- γ-H2AX (1)
- γ-h2ax (1)
- “bulbar-onset” ALS (bALS) (1)
- “limb-onset” ALS (lALS) (1)
Institute
- Theodor-Boveri-Institut für Biowissenschaften (130)
- Institut für Anorganische Chemie (50)
- Medizinische Klinik und Poliklinik I (49)
- Institut für Psychologie (47)
- Medizinische Klinik und Poliklinik II (44)
- Institut für Geographie und Geologie (40)
- Klinik und Poliklinik für Allgemein-, Viszeral-, Gefäß- und Kinderchirurgie (Chirurgische Klinik I) (37)
- Pathologisches Institut (36)
- Institut für Organische Chemie (33)
- Neurologische Klinik und Poliklinik (32)
Sonstige beteiligte Institutionen
- Ökologische Station Fabrikschleichach (2)
- Apotheke, Universitätsklinikum Würzburg (1)
- Bundeswehr Institute of Radiobiology affiliated to the University of Ulm, Munich, Germany (1)
- Clinical Trial Center (CTC) / Zentrale für Klinische Studien Würzburg (ZKSW) (1)
- Department of Cellular Biochemistry, University Medical Center Göttingen (1)
- Department of Nuclear Medicine, Philipps University Marburg, Marburg, Germany (1)
- Georg August University School of Science (1)
- Helmholtz Institute for RNA-based Infection Biology (HIRI), Josef-Schneider-Straße 2/D15, DE-97080 Wuerzburg, Germany (1)
- IZKF Nachwuchsgruppe Geweberegeneration für muskuloskelettale Erkrankungen (1)
- Institute of Cancer Research (ICR) London (1)
Loneliness and lack of social well-being are associated with adverse health outcomes and have increased during the COVID-19 pandemic. Smartphone communication data have been suggested to help monitor loneliness, but this requires further evidence. We investigated the informative value of smartphone communication app data for predicting subjective loneliness and social well-being in a sample of 364 participants ranging from 18 to 78 years of age (52.2% female; mean age = 42.54, SD = 13.22) derived from the CORONA HEALTH APP study from July to December 2020 in Germany. The participants experienced relatively high levels of loneliness and low social well-being during the time period characterized by the COVID-19 pandemic. Apart from positive associations with phone call use times, smartphone communication app use was associated with social well-being and loneliness only when considering the age of participants. Younger participants with higher use times tended to report less social well-being and higher loneliness, while the opposite association was found for older adults. Thus, the informative value of smartphone communication use time was rather small and became evident only in consideration of age. The results highlight the need for further investigations and the need to address several limitations in order to draw conclusions at the population level.
Conversational agents and smart speakers have grown in popularity offering a variety of options for use, which are available through intuitive speech operation. In contrast to the standard dyad of a single user and a device, voice-controlled operations can be observed by further attendees resulting in new, more social usage scenarios. Referring to the concept of ‘media equation’ and to research on the idea of ‘computers as social actors,’ which describes the potential of technology to trigger emotional reactions in users, this paper asks for the capacity of smart speakers to elicit empathy in observers of interactions. In a 2 × 2 online experiment, 140 participants watched a video of a man talking to an Amazon Echo either rudely or neutrally (factor 1), addressing it as ‘Alexa’ or ‘Computer’ (factor 2). Controlling for participants’ trait empathy, the rude treatment results in participants’ significantly higher ratings of empathy with the device, compared to the neutral treatment. The form of address had no significant effect. Results were independent of the participants’ gender and usage experience indicating a rather universal effect, which confirms the basic idea of the media equation. Implications for users, developers and researchers were discussed in the light of (future) omnipresent voice-based technology interaction scenarios.
Purpose
One therapy option for prostate cancer patients with bone metastases is the use of [\(^{223}\)Ra]RaCl\(_{2}\). The α-emitter \(^{223}\)Ra creates DNA damage tracks along α-particle trajectories (α-tracks) in exposed cells that can be revealed by immunofluorescent staining of γ-H2AX+53BP1 DNA double-strand break markers. We investigated the time- and absorbed dose-dependency of the number of α-tracks in peripheral blood mononuclear cells (PBMCs) of patients undergoing their first therapy with [\(^{223}\)Ra]RaCl\(_{2}\).
Methods
Multiple blood samples from nine prostate cancer patients were collected before and after administration of [\(^{223}\)Ra]RaCl\(_{2}\), up to 4 weeks after treatment. γ-H2AX- and 53BP1-positive α-tracks were microscopically quantified in isolated and immuno-stained PBMCs.
Results
The absorbed doses to the blood were less than 6 mGy up to 4 h after administration and maximally 16 mGy in total. Up to 4 h after administration, the α-track frequency was significantly increased relative to baseline and correlated with the absorbed dose to the blood in the dose range < 3 mGy. In most of the late samples (24 h - 4 weeks after administration), the α-track frequency remained elevated.
Conclusion
The γ-H2AX+53BP1 assay is a potent method for detection of α-particle-induced DNA damages during treatment with or after accidental incorporation of radionuclides even at low absorbed doses. It may serve as a biomarker discriminating α- from β-emitters based on damage geometry.
In this communication, we demonstrate a novel approach to prepare a discrete dimer of chiral phthalocyanine (Pc) by exploiting the flexible molecular geometry of helicenes, which enables structural interlocking and strong aggregation tendency of Pcs. Synthesized [7]helicene-Pc hybrid molecular structure, zinc-[7]helicenocyanine (Zn-7HPc), exclusively forms a stable dimeric pair consisting of two homochiral molecules. The dimerization constants were estimated to be as high as 8.96×10\(^6\) M\(^{−1}\) and 3.42×107 M\(^{−1}\) in THF and DMSO, respectively, indicating remarkable stability of dimer. In addition, Zn\(^{-7}\)HPc exhibited chiral self-sorting behavior, which resulted in preferential formation of a homochiral dimer also in the racemic sample. Two phthalocyanine subunits in the dimeric form strongly communicate with each other as revealed by a large comproportionation constant and observation of an IV-CT band for the thermodynamically stable mixed-valence state.
Prerequisite to any biological laboratory assay employing living animals is consideration about its necessity, feasibility, ethics and the potential harm caused during an experiment. The imperative of these thoughts has led to the formulation of the 3R-principle, which today is a pivotal scientific standard of animal experimentation worldwide. The rising amount of laboratory investigations utilizing living animals throughout the last decades, either for regulatory concerns or for basic science, demands the development of alternative methods in accordance with 3R to help reduce experiments in mammals. This demand has resulted in investigation of additional vertebrate species displaying favourable biological properties. One prominent species among these is the zebrafish (Danio rerio), as these small laboratory ray-finned fish are well established in science today and feature outstanding biological characteristics. In this review, we highlight the advantages and general prerequisites of zebrafish embryos and larvae before free-feeding stages for toxicological testing, with a particular focus on cardio-, neuro, hepato- and nephrotoxicity. Furthermore, we discuss toxicokinetics, current advances in utilizing zebrafish for organ toxicity testing and highlight how advanced laboratory methods (such as automation, advanced imaging and genetic techniques) can refine future toxicological studies in this species.
Purpose
High myopic patients may develop strabismus due to globe dislocation out of the normal extraocular muscle cone. Surgical correction of this strabismus type is possible by joining the superior and lateral rectus muscles without the need for a scleral suture called the Yokoyama procedure. Data from large patient samples and the evaluation of a potential effect of an additional medial rectus recession (MRR) have been lacking so far.
Methods
We pooled retrospective patient data of 14 departments of ophthalmology in Germany and Switzerland and analysed determinants of postoperative results using multivariable regression models.
Results
We included 133 patients (mean age: 59.7 ± 13.4 years, surgery between 2008 and 2017) with a mean preoperative esotropia (both Yokoyama with and without MRR) of 23.8°±4.6°. The angle of preoperative esotropia increased with age. The postoperative esotropia was 8.7° ± 9.9°, and six patients were overcorrected. While preoperative esotropia was highly associated with postoperative results, we found no association of additional MRR with any of our postoperative outcome measures. The Yokoyama procedure had a higher absolute effect in patients with higher preoperative esotropia.
Conclusion
Our study confirms the positive effect of the Yokoyama procedure on strabismus due to high myopia in large‐scale real‐world data. In some cases, MRR may be needed because of muscle contracture, although additional MRR statistically did not affect the postoperative outcome. In patients with bilateral high myopic strabismus, correction of both eyes seems beneficial. The effect size of the Yokoyama procedure appears to be mainly driven by preoperative esotropia.
Objective
To examine the efficacy of reminder e-mails to continue yoga therapy on practice frequency and fatigue in cancer patients and long-term effects of yoga on fatigue, depression, and quality of life.
Methology
One hundred two cancer patients who completed an 8-week yoga therapy were randomly allocated to two groups: reminder (N = 51) vs. no-reminder group (N = 51). After completing yoga therapy, the reminder group received weekly e-mails for 24 weeks, which reminded them of practicing yoga, whereas the no-reminder group did not. Primary outcomes were fatigue and practice frequency, and long-term outcomes were fatigue, depression, and quality of life. Data were assessed using questionnaires after yoga therapy (T1) and 6 months after completing yoga therapy (T2).
Result
A significantly stronger reduction of general (p = 0.038, d = 0.42) and emotional fatigue (p = 0.004, d = 0.59) and a higher increase of practice frequency (p = 0.015, d = 0.52) between T1 and T2 were found for the reminder group compared to the no-reminder group. In the mediation model, practice frequency as a mediator partially explained the changes in emotional fatigue (indirect effect B = - 0.10). Long-term effects of yoga therapy regarding fatigue, depression, and quality of life were found (F > 7.46, p < 0.001, d > 0.54).
Conclusion
Weekly reminder e-mails after yoga therapy can positively affect general and emotional fatigue and help cancer patients with fatigue establish a regular yoga practice at home. However, higher practice frequency did not lead to higher physical or cognitive fatigue improvement, suggesting other factors that mediate efficacy on physical or cognitive fatigue, such as mindfulness or side effects of therapy.
Purpose
Examine the effects of an 8-week yoga therapy on fatigue in patients with different types of cancer.
Methods
A total of 173 cancer patients suffering from mild to severe fatigue were randomly allocated to yoga intervention (n = 84) (IG) versus waitlist control group (CG) (n = 88). Yoga therapy consisted of eight weekly sessions with 60 min each. The primary outcome was self-reported fatigue symptoms. Secondary outcomes were symptoms of depression and quality of life (QoL). Data were assessed using questionnaires before (T0) and after yoga therapy for IG versus waiting period for CG (T1).
Results
A stronger reduction of general fatigue (P = .033), physical fatigue (P = .048), and depression (P < .001) as well as a stronger increase in QoL (P = .002) was found for patients who attended 7 or 8 sessions compared with controls. Within the yoga group, both higher attendance rate and lower T0-fatigue were significant predictors of lower T1-fatigue (P ≤ .001). Exploratory results revealed that women with breast cancer report a higher reduction of fatigue than women with other types of cancer (P = .016) after yoga therapy.
Conclusion
The findings support the assumption that yoga therapy is useful to reduce cancer-related fatigue, especially for the physical aspects of fatigue. Women with breast cancer seem to benefit most, and higher attendance rate results in greater reduction of fatigue.
Trial registration
German Clinical Trials Register DRKS00016034
Many species synchronize reproductive behavior with a particular phase of the lunar cycle to increase reproductive success. In humans, a lunar influence on reproductive behavior remains controversial, although the human menstrual cycle has a period close to that of the lunar cycle. Here, we analyzed long-term menstrual recordings of individual women with distinct methods for biological rhythm analysis. We show that women’s menstrual cycles with a period longer than 27 days were intermittently synchronous with the Moon’s luminance and/or gravimetric cycles. With age and upon exposure to artificial nocturnal light, menstrual cycles shortened and lost this synchrony. We hypothesize that in ancient times, human reproductive behavior was synchronous with the Moon but that our modern lifestyles have changed reproductive physiology and behavior.
Loss of Somatostatin Receptor 2 (SSTR2) expression and rising CXC Chemokine Receptor Type 4 (CXCR4) expression are associated with dedifferentiation in neuroendocrine tumors (NET). In NET, CXCR4 expression is associated with enhanced metastatic and invasive potential and worse prognosis but might be a theragnostic target. Likewise, activation of Wnt/β-catenin signaling may promote a more aggressive phenotype in NET. We hypothesized an interaction of the Wnt/β-catenin pathway with CXCR4 expression and function in NET. The NET cell lines BON-1, QGP-1, and MS-18 were exposed to Wnt inhibitors (5-aza-CdR, quercetin, and niclosamide) or the Wnt activator LiCl. The expressions of Wnt pathway genes and of CXCR4 were studied by qRT-PCR, Western blot, and immunohistochemistry. The effects of Wnt modulators on uptake of the CXCR4 ligand [\(^{68}\)Ga] Pentixafor were measured. The Wnt activator LiCl induced upregulation of CXCR4 and Wnt target gene expression. Treatment with the Wnt inhibitors had opposite effects. LiCl significantly increased [\(^{68}\)Ga] Pentixafor uptake, while treatment with Wnt inhibitors decreased radiopeptide uptake. Wnt pathway modulation influences CXCR4 expression and function in NET cell lines. Wnt modulation might be a tool to enhance the efficacy of CXCR4-directed therapies in NET or to inhibit CXCR4-dependent proliferative signaling. The underlying mechanisms for the interaction of the Wnt pathway with CXCR4 expression and function have yet to be clarified.
Wilms' tumor primary cells display potent immunoregulatory properties on NK cells and macrophages
(2021)
The immune response plays a crucial defensive role in cancer growth and metastasis and is a promising target in different tumors. The role of the immune system in Wilm’s Tumor (WT), a common pediatric renal malignancy, is still to be explored. The characterization of the immune environment in WT could allow the identification of new therapeutic strategies for targeting possible inhibitory mechanisms and/or lowering toxicity of the current treatments. In this study, we stabilized four WT primary cultures expressing either a blastematous (CD56\(^+\)/CD133\(^−\)) or an epithelial (CD56\(^−\)/CD133\(^+\)) phenotype and investigated their interactions with innate immune cells, namely NK cells and monocytes. We show that cytokine-activated NK cells efficiently kill WT cells. However, after co-culture with WT primary cells, NK cells displayed an impaired cytotoxic activity, decreased production of IFNγ and expression of CD107a, DNAM-1 and NKp30. Analysis of the effects of the interaction between WT cells and monocytes revealed their polarization towards alternatively activated macrophages (M2) that, in turn, further impaired NK cell functions. In conclusion, we show that both WT blastematous and epithelial components may contribute directly and indirectly to a tumor immunosuppressive microenvironment that is likely to play a role in tumor progression.
Purpose
This study investigates the redislocation rate and functional outcome at a minimum follow-up of five years after medial patellofemoral ligament (MPFL) reconstruction with soft tissue patellar fixation for patella instability.
Methods
Patients were retrospectively identified and knees were evaluated for trochlea dysplasia according to Dejour, for presence of patella alta and for presence of cartilage lesion at surgery. At a minimum follow-up of five years, information about an incident of redislocation was obtained. Kujala, Lysholm, and Tegner questionnaires as well as range of motion were used to measure functional outcome.
Results
Eighty-nine knees were included. Follow-up rate for redislocation was 79.8% and for functional outcome 58.4%. After a mean follow-up of 5.8 years, the redislocation rate was 5.6%. There was significant improvement of the Kujala score (68.8 to 88.2, p = 0.000) and of the Lysholm score (71.3 to 88.4, p = 0.000). Range of motion at follow-up was 149.0° (115–165). 77.5% of the knees had patella alta and 52.9% trochlear dysplasia types B, C, or D. Patellar cartilage legions were present in 54.2%. Redislocations occurred in knees with trochlear dysplasia type C in combination with patella alta.
Conclusion
MPFL reconstruction with soft tissue patellar fixation leads to significant improvement of knee function and low midterm redislocation rate. Patients with high-grade trochlear dysplasia should be considered for additional osseous correction.
Whole-Body [\(^{18}\)F]FDG PET/CT Can Alter Diagnosis in Patients with Suspected Rheumatic Disease
(2021)
The 2-deoxy-d-[\(^{18}\)F]fluoro-D-glucose (FDG) positron emission tomography/computed tomography (PET/CT) is widely utilized to assess the vascular and articular inflammatory burden of patients with a suspected diagnosis of rheumatic disease. We aimed to elucidate the impact of [\(^{18}\)F]FDG PET/CT on change in initially suspected diagnosis in patients at the time of the scan. Thirty-four patients, who had undergone [\(^{18}\)F]FDG PET/CT, were enrolled and the initially suspected diagnosis prior to [18F]FDG PET/CT was compared to the final diagnosis. In addition, a semi-quantitative analysis including vessel wall-to-liver (VLR) and joint-to-liver (JLR) ratios was also conducted. Prior to [\(^{18}\)F]FDG PET/CT, 22/34 (64.7%) of patients did not have an established diagnosis, whereas in 7/34 (20.6%), polymyalgia rheumatica (PMR) was suspected, and in 5/34 (14.7%), giant cell arteritis (GCA) was suspected by the referring rheumatologists. After [\(^{18}\)F]FDG PET/CT, the diagnosis was GCA in 19/34 (55.9%), combined GCA and PMR (GCA + PMR) in 9/34 (26.5%) and PMR in the remaining 6/34 (17.6%). As such, [\(^{18}\)F]FDG PET/CT altered suspected diagnosis in 28/34 (82.4%), including in all unclear cases. VLR of patients whose final diagnosis was GCA tended to be significantly higher when compared to VLR in PMR (GCA, 1.01 ± 0.08 (95%CI, 0.95–1.1) vs. PMR, 0.92 ± 0.1 (95%CI, 0.85–0.99), p = 0.07), but not when compared to PMR + GCA (1.04 ± 0.14 (95%CI, 0.95–1.13), p = 1). JLR of individuals finally diagnosed with PMR (0.94 ± 0.16, (95%CI, 0.83–1.06)), however, was significantly increased relative to JLR in GCA (0.58 ± 0.04 (95%CI, 0.55–0.61)) and GCA + PMR (0.64 ± 0.09 (95%CI, 0.57–0.71); p < 0.0001, respectively). In individuals with a suspected diagnosis of rheumatic disease, an inflammatory-directed [\(^{18}\)F]FDG PET/CT can alter diagnosis in the majority of the cases, particularly in subjects who were referred because of diagnostic uncertainty. Semi-quantitative assessment may be helpful in establishing a final diagnosis of PMR, supporting the notion that a quantitative whole-body read-out may be useful in unclear cases.
A relevant issue on the treatment of adrenocortical carcinoma (ACC) concerns the optimal duration of adjuvant mitotane treatment. We tried to address this question, assessing whether a correlation exists between the duration of adjuvant mitotane treatment and recurrence-free survival (RFS) of patients with ACC. We conducted a multicenter retrospective analysis on 154 ACC patients treated for ≥12 months with adjuvant mitotane after radical surgery and who were free of disease at the mitotane stop. During a median follow-up of 38 months, 19 patients (12.3%) experienced recurrence. We calculated the RFS after mitotane (RFSAM), from the landmark time-point of mitotane discontinuation, to overcome immortal time bias. We found a wide variability in the duration of adjuvant mitotane treatment among different centers and also among patients cared for at the same center, reflecting heterogeneous practice. We did not find any survival advantage in patients treated for longer than 24 months. Moreover, the relationship between treatment duration and the frequency of ACC recurrence was not linear after stratifying our patients in tertiles of length of adjuvant treatment. In conclusion, the present findings do not support the concept that extending adjuvant mitotane treatment over two years is beneficial for ACC patients with low to moderate risk of recurrence.
The extinction of species is a non‐random process, and understanding why some species are more likely to go extinct than others is critical for conservation efforts. Functional trait‐based approaches offer a promising tool to achieve this goal. In forests, deadwood‐dependent (saproxylic) beetles comprise a major part of threatened species, but analyses of their extinction risk have been hindered by the availability of suitable morphological traits.
To better understand the mechanisms underlying extinction in insects, we investigated the relationships between morphological features and the extinction risk of saproxylic beetles. Specifically, we hypothesised that species darker in colour, with a larger and rounder body, a lower mobility, lower sensory perception and more robust mandibles are at higher risk.
We first developed a protocol for morphological trait measurements and present a database of 37 traits for 1,157 European saproxylic beetle species. Based on 13 selected, independent traits characterising aspects of colour, body shape, locomotion, sensory perception and foraging, we used a proportional‐odds multiple linear mixed‐effects model to model the German Red List categories of 744 species as an ordinal index of extinction risk.
Six out of 13 traits correlated significantly with extinction risk. Larger species as well as species with a broad and round body had a higher extinction risk than small, slim and flattened species. Species with short wings had a higher extinction risk than those with long wings. On the contrary, extinction risk increased with decreasing wing load and with higher mandibular aspect ratio (shorter and more robust mandibles).
Our study provides new insights into how morphological traits, beyond the widely used body size, determine the extinction risk of saproxylic beetles. Moreover, our approach shows that the morphological characteristics of beetles can be comprehensively represented by a selection of 13 traits. We recommend them as a starting point for functional analyses in the rapidly growing field of ecological and conservation studies of deadwood.
Chronic hepatitis C can be treated very effectively with direct-acting antivirals (DAA) with only minor side effects compared to an interferon-containing treatment regimen. The significance of metabolic comorbidities after HCV cure is not well defined. This study aims to investigate short- and long-term weight change of patients receiving interferon-free antiviral treatment for chronic hepatitis C. The German Hepatitis C-registry (DHC-R) is a national multicenter real-world cohort. A total of 5111 patients were followed prospectively after DAA treatment for up to 3 years. Weight change compared to baseline was analyzed at end of treatment and at years 1, 2, and 3 after completion of antiviral therapy. Regression analysis was performed to identify baseline predictors for weight change. While there was no relevant mean weight change (−0.2 kg, SD 4.3 kg) at the end of antiviral treatment, weight started to increase during long-term follow-up reaching +1.7 kg (SD 8.0 kg, p < 0.001) compared to baseline at 3 years (follow-up year 3, FU3) after completion of antiviral therapy. 48%, 31%, and 22% of patients had a weight gain greater than 1, 3, and 5 kg at FU3, respectively. During follow-up, a body mass index (BMI) <30 proved to be the only consistent predictor for weight gain. DAA treatment is followed by a substantial weight gain (+3 kg or more) in one-third of the patients during long-term follow-up. Non-obese patients seemed to be most vulnerable to weight gain. The body compartment involved in weight gain as well as the mechanism of weight gain remain to be elucidated.
Farmland tree cultivation is considered an important option for enhancing wood production. In South India, the native leaf-deciduous tree species Melia dubia is popular for short-rotation plantations. Across a rainfall gradient from 420 to 2170 mm year\(^{–1}\), we studied 186 farmland woodlots between one and nine years in age. The objectives were to identify the main factors controlling aboveground biomass (AGB) and growth rates. A power-law growth model predicts an average stand-level AGB of 93.8 Mg ha\(^{–1}\) for nine-year-old woodlots. The resulting average annual AGB increment over the length of the rotation cycle is 10.4 Mg ha\(^{–1}\) year\(^{–1}\), which falls within the range reported for other tropical tree plantations. When expressing the parameters of the growth model as functions of management, climate and soil variables, it explains 65% of the variance in AGB. The results indicate that water availability is the main driver of the growth of M. dubia. Compared to the effects of water availability, the effects of soil nutrients are 26% to 60% smaller. We conclude that because of its high biomass accumulation rates in farm forestry, M. dubia is a promising candidate for short-rotation plantations in South India and beyond.
Myeloid-derived suppressor cells (MDSCs) represent a major population controlling T cell immune responses. However, little is known about their molecular requirements for homing and T cell interaction to mediate suppression. Here, we investigated the functional role of the homing and collagen IV receptor VLA-1 (α1β1-integrin) on in vitro GM-CSF generated murine MDSCs from wild-type (WT) and CD49a/α1-integrin (Itga1\(^{−/−}\)) gene-deficient mice. Here, we found that effector (Teff) but not naive (Tn) CD4\(^+\) T cells express VLA-1 and monocytes further up-regulated their expression after culture in GM-CSF when they differentiated into the monocytic subset of resting MDSCs (R-MDSCs). Subsequent activation of R-MDSCs by LPS+IFN-γ (A-MDSCs) showed increased in vitro suppressor potential, which was independent of VLA-1. Surprisingly, VLA-1 deficiency did not influence A-MDSC motility or migration on collagen IV in vitro. However, interaction times of Itga1\(^{−/−}\) A-MDSCs with Teff were shorter than with WT A-MDSCs on collagen IV but not on fibronectin substrate in vitro. After injection, A-MDSCs homed to the splenic red pulp where they co-localized with Teff and showed immediate suppression already after 6 h as shown by inhibition of T cell proliferation and induction of apoptosis. Injection of A-MDSCs from Itga1\(^{−/−}\) mice showed equivalent homing into the spleen but a reduced suppressive effect. Interaction studies of A-MDSCs with Teff in the subcapsular red pulp with intravital two-photon microscopy revealed also here that MDSC motility and migration parameters were not altered by VLA-1 deficiency, but the interaction times with Teff were reduced. Together, our data point to a new role of VLA-1 adhesion to collagen IV as a prerequisite for extended contact times with Teff required for suppression.
(1) Background: Evidence has accumulated that patients with anorexia nervosa (AN) are at higher risk for vitamin D deficiency than healthy controls. In epidemiologic studies, low 25(OH) vitamin D (25(OH)D) levels were associated with depression. This study analyzed the relationship between 25(OH)D serum levels in adolescent patients and AN and depressive symptoms over the course of treatment. (2) Methods: 25(OH)D levels and depressive symptoms were analyzed in 93 adolescent (in-)patients with AN from the Anorexia Nervosa Day patient versus Inpatient (ANDI) multicenter trial at clinic admission, discharge, and 1 year follow up. Mixed regression models were used to analyze the relationship between 25(OH)D levels and depressive symptoms assessed by the Beck Depression Inventory (BDI-II). (3) Results: Although mean 25(OH)D levels constantly remained in recommended ranges (≥50 nmol/L) during AN treatment, levels decreased from (in)patient admission to 1 year follow up. Levels of 25(OH)D were neither cross-sectionally, prospectively, nor longitudinally associated with the BDI-II score. (4) Conclusions: This study did not confirm that 25(OH)D levels are associated with depressive symptoms in patients with AN. However, increasing risks of vitamin D deficiency over the course of AN treatment indicate that clinicians should monitor 25(OH)D levels.
Strains of the food-borne pathogen Listeria (L.) monocytogenes have diverse virulence potential. This study focused on the virulence of three outbreak strains: the CC1 strain PF49 (serovar 4b) from a cheese-associated outbreak in Switzerland, the clinical CC2 strain F80594 (serovar 4b), and strain G6006 (CC3, serovar 1/2a), responsible for a large gastroenteritis outbreak in the USA due to chocolate milk. We analysed the genomes and characterized the virulence in vitro and in vivo. Whole-genome sequencing revealed a high conservation of the major virulence genes. Minor deviations of the gene contents were found in the autolysins Ami, Auto, and IspC. Moreover, different ActA variants were present. Strain PF49 and F80594 showed prolonged survival in the liver of infected mice. Invasion and intracellular proliferation were similar for all strains, but the CC1 and CC2 strains showed increased spreading in intestinal epithelial Caco2 cells compared to strain G6006. Overall, this study revealed long-term survival of serovar 4b strains F80594 and PF49 in the liver of mice. Future work will be needed to determine the genes and molecular mechanism behind the long-term survival of L. monocytogenes strains in organs.
Virtual online training has emerged as one of the top 20 worldwide fitness trends for 2021 and continues to develop rapidly. Although this allows the cycling community to engage in virtual training and competition, critical evaluation of virtual training platforms is limited. Here, we discuss the strengths, weaknesses, opportunities and threats associated with virtual training technology and cycling in an attempt to enhance awareness of such aspects. Strengths include immersive worlds, innovative drafting mechanics, and versatility. Weaknesses include questionable data accuracy, inadequate strength and reliability of power-speed algorithms. Opportunities exist for expanding strategic partnerships with major cycling races, brands, and sponsors and improving user experience with the addition of video capture and “e-coaching.” Threats are present in the form of cheating during competition, and a lack of uptake and acceptance by a broader community.
The differentiation of human induced pluripotent stem cells (hiPSCs) into specific cell types for disease modeling and restorative therapies is a key research agenda and offers the possibility to obtain patient-specific cells of interest for a wide range of diseases. Basal forebrain cholinergic neurons (BFCNs) play a particular role in the pathophysiology of Alzheimer’s dementia and isolated dystonias. In this work, various directed differentiation protocols based on monolayer neural induction were tested for their effectiveness in promoting a ventral telencephalic phenotype and generating BFCN. Ventralizing factors [i.e., purmorphamine and Sonic hedgehog (SHH)] were applied at different time points, time intervals, and concentrations. In addition, caudal identity was prevented by the use of a small molecule XAV-939 that inhibits the Wnt-pathway. After patterning, gene expression profiles were analyzed by quantitative PCR (qPCR). Rostro-ventral patterning is most effective when initiated simultaneously with neural induction. The most promising combination of patterning factors was 0.5 μM of purmorphamine and 1 μM of XAV-939, which induces the highest expression of transcription factors specific for the medial ganglionic eminence, the source of GABAergic inter- and cholinergic neurons in the telencephalon. Upon maturation of cells, the immune phenotype, as well as electrophysiological properties were investigated showing the presence of marker proteins specific for BFCN (choline acetyltransferase, ISL1, p75, and NKX2.1) and GABAergic neurons. Moreover, a considerable fraction of measured cells displayed mature electrophysiological properties. Synaptic boutons containing the vesicular acetylcholine transporter (VACHT) could be observed in the vicinity of the cells. This work will help to generate basal forebrain interneurons from hiPSCs, providing a promising platform for modeling neurological diseases, such as Alzheimer’s disease or Dystonia.
Freely available satellite data at Google Earth Engine (GEE) cloud platform enables vegetation phenology analysis across different scales very efficiently. We evaluated seasonal and annual phenology of the old-growth Hyrcanian forests (HF) of northern Iran covering an area of ca. 1.9 million ha, and also focused on 15 UNESCO World Heritage Sites. We extracted bi-weekly MODIS-NDVI between 2017 and 2020 in GEE, which was used to identify the range of NDVI between two temporal stages. Then, changes in phenology and growth were analyzed by Sentinel 2-derived Temporal Normalized Phenology Index. We modelled between seasonal phenology and growth by additionally considering elevation, surface temperature, and monthly precipitation. Results indicated considerable difference in onset of forests along the longitudinal gradient of the HF. Faster growth was observed in low- and uplands of the western zone, whereas it was lower in both the mid-elevations and the western outskirts. Longitudinal range was a major driver of vegetation growth, to which environmental factors also differently but significantly contributed (p < 0.0001) along the west-east gradient. Our study developed at GEE provides a benchmark to examine the effects of environmental parameters on the vegetation growth of HF, which cover mountainous areas with partly no or limited accessibility.
The clinical and preclinical research of ischemic strokes (IS) is becoming increasingly comprehensive, especially with the emerging evidence of complex thrombotic and inflammatory interactions. Within these, the blood brain barrier (BBB) plays an important role in regulating the cellular interactions at the vascular interface and is therefore the object of many IS-related questions. Consequently, valid, economic and responsible methods to define BBB integrity are necessary. Therefore, we compared the three ex-vivo setups albumin Western blot (WB), IgG WB and albumin intensity measurement (AIM) with regard to validity as well as temporal and economic efficacy. While the informative value of the three methods correlated significantly, the efficacy of the IgG WB dominated.
Land Surface Temperature (LST) is an important parameter for tracing the impact of changing climatic conditions on our environment. Describing the interface between long- and shortwave radiation fluxes, as well as between turbulent heat fluxes and the ground heat flux, LST plays a crucial role in the global heat balance. Satellite-derived LST is an indispensable tool for monitoring these changes consistently over large areas and for long time periods. Data from the AVHRR (Advanced Very High-Resolution Radiometer) sensors have been available since the early 1980s. In the TIMELINE project, LST is derived for the entire operating period of AVHRR sensors over Europe at a 1 km spatial resolution. In this study, we present the validation results for the TIMELINE AVHRR daytime LST. The validation approach consists of an assessment of the temporal consistency of the AVHRR LST time series, an inter-comparison between AVHRR LST and in situ LST, and a comparison of the AVHRR LST product with concurrent MODIS (Moderate Resolution Imaging Spectroradiometer) LST. The results indicate the successful derivation of stable LST time series from multi-decadal AVHRR data. The validation results were investigated regarding different LST, TCWV and VA, as well as land cover classes. The comparisons between the TIMELINE LST product and the reference datasets show seasonal and land cover-related patterns. The LST level was found to be the most determinative factor of the error. On average, an absolute deviation of the AVHRR LST by 1.83 K from in situ LST, as well as a difference of 2.34 K from the MODIS product, was observed.
Crowdsourced network measurements (CNMs) are becoming increasingly popular as they assess the performance of a mobile network from the end user's perspective on a large scale. Here, network measurements are performed directly on the end-users' devices, thus taking advantage of the real-world conditions end-users encounter. However, this type of uncontrolled measurement raises questions about its validity and reliability. The problem lies in the nature of this type of data collection. In CNMs, mobile network subscribers are involved to a large extent in the measurement process, and collect data themselves for the operator. The collection of data on user devices in arbitrary locations and at uncontrolled times requires means to ensure validity and reliability. To address this issue, our paper defines concepts and guidelines for analyzing the precision of CNMs; specifically, the number of measurements required to make valid statements. In addition to the formal definition of the aspect, we illustrate the problem and use an extensive sample data set to show possible assessment approaches. This data set consists of more than 20.4 million crowdsourced mobile measurements from across France, measured by a commercial data provider.
Purpose
The value of bladder cancer (BC) substaging into macroscopic (pT3b) and microscopic (pT3a) perivesical fat extension in lymph node (Ln)-negative patients is controversially discussed and limited evidence for prognostic relevance of additional histopathological factors in pT3 BC exists. We evaluated the prognostic value of pT3 substaging and established pathological and clinical parameters with focus on tumor invasive front (TIF) and tumor size.
Methods
Specimens of 52 patients treated with radical cystectomy (RC) for pT3 a/b muscle-invasive BC were reviewed and re-evaluated by a pathologist specialized in uropathology. Clinical variables and standard histopathologic characteristics were assessed including TIF and tumor size. Their value as prognosticators for overall survival (OS) and recurrence-free survival (RFS) was evaluated.
Results
Mean age of patients was 67.55 years. Tumors were staged pT3a in 28 patients (53.8%) and pT3b in 24 (46.8%). Median OS was 34.51 months. Median tumor size was 3.2 cm, median TIF was 11.0 mm. Differences in OS between pT3a and pT3b were not significant (p = 0.45). Carcinoma in situ (CIS) and lymphovascular invasion (LVI) were significantly associated with pT3b tumors. Univariate analysis could not identify pathological prognosticators like TIF or tumor size for OS and RFS (p for all > 0.05).
Conclusion
No significant differences in OS or RFS were observed comparing Ln-negative pT3 BC following radical cystectomy. Additional pathologic variables like TIF could not be identified as prognosticator. Relevance of pT3 BC substaging needs reevaluation in larger prospective cohorts.
Squamous cell carcinomas are therapeutically challenging tumor entities. Low response rates to radiotherapy and chemotherapy are commonly observed in squamous patients and, accordingly, the mortality rate is relatively high compared to other tumor entities. Recently, targeting USP28 has been emerged as a potential alternative to improve the therapeutic response and clinical outcomes of squamous patients. USP28 is a catalytically active deubiquitinase that governs a plethora of biological processes, including cellular proliferation, DNA damage repair, apoptosis and oncogenesis. In squamous cell carcinoma, USP28 is strongly expressed and stabilizes the essential squamous transcription factor ΔNp63, together with important oncogenic factors, such as NOTCH1, c-MYC and c-JUN. It is presumed that USP28 is an oncoprotein; however, recent data suggest that the deubiquitinase also has an antineoplastic effect regulating important tumor suppressor proteins, such as p53 and CHK2. In this review, we discuss: (1) The emerging role of USP28 in cancer. (2) The complexity and mutational landscape of squamous tumors. (3) The genetic alterations and cellular pathways that determine the function of USP28 in squamous cancer. (4) The development and current state of novel USP28 inhibitors.
This paper examines situations where two vertically integrated firms consider supplying an input to an independent downstream competitor via privately observed contracts. We identify equilibria where competition in the upstream market emerges—the downstream competitor gets supplied—as well as when the downstream firm does not receive the input and is excluded from the market. The likelihood of the outcome in which the downstream firm does not get supplied depends not only on demand parameters, but also on contractual flexibility and observability. We show that when contracts are unobservable, downstream entry will occur less often. Furthermore, our results suggest that permitting contracts that enable the contracting parties to coordinate their behavior in the downstream market may improve welfare by increasing the likelihood that the downstream firm is supplied.
Uplink vs. Downlink: Machine Learning-Based Quality Prediction for HTTP Adaptive Video Streaming
(2021)
Streaming video is responsible for the bulk of Internet traffic these days. For this reason, Internet providers and network operators try to make predictions and assessments about the streaming quality for an end user. Current monitoring solutions are based on a variety of different machine learning approaches. The challenge for providers and operators nowadays is that existing approaches require large amounts of data. In this work, the most relevant quality of experience metrics, i.e., the initial playback delay, the video streaming quality, video quality changes, and video rebuffering events, are examined using a voluminous data set of more than 13,000 YouTube video streaming runs that were collected with the native YouTube mobile app. Three Machine Learning models are developed and compared to estimate playback behavior based on uplink request information. The main focus has been on developing a lightweight approach using as few features and as little data as possible, while maintaining state-of-the-art performance.
Background: With the availability of T-cell-directed therapy and next-generation compounds of established classes of drugs, the treatment of relapsed/refractory (r/r) myeloma is getting more complex. However, treatment options in practice are limited by availability, approval, and patient comorbidity. The aim of this article is to provide a practical approach toward the choice of treatment for r/r myeloma patients. Summary: Regarding market authorization and current guidelines, at least in Germany, most patients nowadays will have received a doublet or triplet combination as first-line therapy containing a proteasome inhibitor and an immunomodulatory drug, mostly lenalidomide. We focus on the treatment options for patients that are ineligible for (another) stem cell transplantation. We will review treatment options for relapse after first- or second-line therapy and beyond third-line. Key Messages: There is promising data supporting the efficacy and safety of triplet combinations containing anti-CD38-monoclonal antibodies (anti-CD38 mAbs) at first or second relapse in combination with next-generation compounds. For the treatment beyond third-line, comparative studies are scarce but some promising compounds are available via conditional authorization, and there is more to come in the future. We will present some early phase trials featuring promising results.
The bounded input bounded output (BIBO) stability for a nonlinear Caputo fractional system with time‐varying bounded delay and nonlinear output is studied. Utilizing the Razumikhin method, Lyapunov functions and appropriate fractional derivatives of Lyapunov functions some new bounded input bounded output stability criteria are derived. Also, explicit and independent on the initial time bounds of the output are provided. Uniform BIBO stability and uniform BIBO stability with input threshold are studied. A numerical simulation is carried out to show the system's dynamic response, and demonstrate the effectiveness of our theoretical results.
African trypanosomes cause sleeping sickness in humans and nagana in cattle. These unicellular parasites are transmitted by the bloodsucking tsetse fly. In the mammalian host’s circulation, proliferating slender stage cells differentiate into cell cycle-arrested stumpy stage cells when they reach high population densities. This stage transition is thought to fulfil two main functions: first, it auto-regulates the parasite load in the host; second, the stumpy stage is regarded as the only stage capable of successful vector transmission. Here, we show that proliferating slender stage trypanosomes express the mRNA and protein of a known stumpy stage marker, complete the complex life cycle in the fly as successfully as the stumpy stage, and require only a single parasite for productive infection. These findings suggest a reassessment of the traditional view of the trypanosome life cycle. They may also provide a solution to a long-lasting paradox, namely the successful transmission of parasites in chronic infections, despite low parasitemia.
Soil salinity is an increasingly global problem which hampers plant growth and crop yield. Plant productivity depends on optimal water-use efficiency and photosynthetic capacity balanced by stomatal conductance. Whether and how stomatal behavior contributes to salt sensitivity or tolerance is currently unknown. This work identifies guard cell-specific signaling networks exerted by a salt-sensitive and salt-tolerant plant under ionic and osmotic stress conditions accompanied by increasing NaCl loads.
We challenged soil-grown Arabidopsis thaliana and Thellungiella salsuginea plants with short- and long-term salinity stress and monitored genome-wide gene expression and signals of guard cells that determine their function.
Arabidopsis plants suffered from both salt regimes and showed reduced stomatal conductance while Thellungiella displayed no obvious stress symptoms. The salt-dependent gene expression changes of guard cells supported the ability of the halophyte to maintain high potassium to sodium ratios and to attenuate the abscisic acid (ABA) signaling pathway which the glycophyte kept activated despite fading ABA concentrations.
Our study shows that salinity stress and even the different tolerances are manifested on a single cell level. Halophytic guard cells are less sensitive than glycophytic guard cells, providing opportunities to manipulate stomatal behavior and improve plant productivity.
Purpose
Evaluation of clinical outcome of two-weekly high-dose-rate brachytherapy boost after external beam radiotherapy (EBRT) for localized prostate cancer.
Methods
338 patients with localized prostate cancer receiving definitive EBRT followed by a two-weekly high-dose-rate brachytherapy boost (HDR-BT boost) in the period of 2002 to 2019 were analyzed. EBRT, delivered in 46 Gy (DMean) in conventional fractionation, was followed by two fractions HDR-BT boost with 9 Gy (D90%) two and four weeks after EBRT. Androgen deprivation therapy (ADT) was added in 176 (52.1%) patients. Genitourinary (GU)/gastrointestinal (GI) toxicity was evaluated utilizing the Common Toxicity Criteria for Adverse Events (version 5.0) and biochemical failure was defined according to the Phoenix definition.
Results
Median follow-up was 101.8 months. 15 (4.4%)/115 (34.0%)/208 (61.5%) patients had low-/intermediate-/high-risk cancer according to the D`Amico risk classification. Estimated 5-year and 10-year biochemical relapse-free survival (bRFS) was 84.7% and 75.9% for all patients. The estimated 5-year bRFS was 93.3%, 93.4% and 79.5% for low-, intermediate- and high-risk disease, respectively. The estimated 10-year freedom from distant metastasis (FFM) and overall survival (OS) rates were 86.5% and 70.0%. Cumulative 5-year late GU toxicity and late GI toxicity grade ≥ 2 was observed in 19.3% and 5.0% of the patients, respectively. Cumulative 5-year late grade 3 GU/GI toxicity occurred in 3.6%/0.3%.
Conclusions
Two-weekly HDR-BT boost after EBRT for localized prostate cancer showed an excellent toxicity profile with low GU/GI toxicity rates and effective long-term biochemical control.
Many proteins are molecular machines, whose function is dependent on multiple conformational changes that are initiated and tightly controlled through biochemical stimuli. Their mechanistic understanding calls for spectroscopy that can probe simultaneously such structural coordinates. Here we present two-colour fluorescence microscopy in combination with photoinduced electron transfer (PET) probes as a method that simultaneously detects two structural coordinates in single protein molecules, one colour per coordinate. This contrasts with the commonly applied resonance energy transfer (FRET) technique that requires two colours per coordinate. We demonstrate the technique by directly and simultaneously observing three critical structural changes within the Hsp90 molecular chaperone machinery. Our results reveal synchronicity of conformational motions at remote sites during ATPase-driven closure of the Hsp90 molecular clamp, providing evidence for a cooperativity mechanism in the chaperone’s catalytic cycle. Single-molecule PET fluorescence microscopy opens up avenues in the multi-dimensional exploration of protein dynamics and allosteric mechanisms.
Background: Chimeric antigen receptor (CAR) T-cells are changing the therapeutic landscape of hematologic malignancies. Severe side effects include cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS), but prolonged cytopenia has also been reported. The underlying mechanism for prolonged cytopenia is poorly understood so far. Cases: Severe pancytopenia with grade 2-3 anemia was marked 2–3 months after treatment. Laboratory evaluation revealed undetectable levels of haptoglobin with increased reticulocyte counts. Coomb's tests were negative, no schistocytes were detected on blood smear, and infectious causes were ruled out. Increased erythropoiesis without lymphoma infiltration was noted on bone marrow biopsy. A spontaneous increase in haptoglobin and hemoglobin levels was observed after several weeks. For one patient, peripheral CAR-T levels were monitored over time. We observed a decline at the same time as hemoglobin levels began to rise, implying a potential causality. Conclusion: To our knowledge, we describe the first two cases of Coombs-negative hemolytic anemia after CAR-T treatment for B-cell lymphoma. We encourage routine monitoring for hemolytic anemia after CAR-T treatment and also encourage further investigations on the underlying mechanism.
Twisted boron-based biradicals featuring unsaturated C\(_2\)R\(_2\) (R=Et, Me) bridges and stabilization by cyclic (alkyl)(amino)carbenes (CAACs) were recently prepared. These species show remarkable geometrical and electronic differences with respect to their unbridged counterparts. Herein, a thorough computational investigation on the origin of their distinct electrostructural properties is performed. It is shown that steric effects are mostly responsible for the preference for twisted over planar structures. The ground-state multiplicity of the twisted structure is modulated by the σ framework of the bridge, and different R groups lead to distinct multiplicities. In line with the experimental data, a planar structure driven by delocalization effects is observed as global minimum for R=H. The synthetic elusiveness of C\(_2\)R\(_2\)-bridged systems featuring N-heterocyclic carbenes (NHCs) was also investigated. These results could contribute to the engineering of novel main group biradicals.
Objectives
Trauma evaluation of extremities can be challenging in conventional radiography. A multi-use x-ray system with cone-beam CT (CBCT) option facilitates ancillary 3-D imaging without repositioning. We assessed the clinical value of CBCT scans by analyzing the influence of additional findings on therapy.
Methods
Ninety-two patients underwent radiography and subsequent CBCT imaging with the twin robotic scanner (76 wrist/hand/finger and 16 ankle/foot/toe trauma scans). Reports by on-call radiologists before and after CBCT were compared regarding fracture detection, joint affliction, comminuted injuries, and diagnostic confidence. An orthopedic surgeon recommended therapy based on reported findings. Surgical reports (N = 52) and clinical follow-up (N = 85) were used as reference standard.
Results
CBCT detected more fractures (83/64 of 85), joint involvements (69/53 of 71), and multi-fragment situations (68/50 of 70) than radiography (all p < 0.001). Six fractures suspected in radiographs were ruled out by CBCT. Treatment changes based on additional information from CBCT were recommended in 29 patients (31.5%). While agreement between advised therapy before CBCT and actual treatment was moderate (κ = 0.41 [95% confidence interval 0.35–0.47]; p < 0.001), agreement after CBCT was almost perfect (κ = 0.88 [0.83–0.93]; p < 0.001). Diagnostic confidence increased considerably for CBCT studies (p < 0.001). Median effective dose for CBCT was 4.3 μSv [3.3–5.3 μSv] compared to 0.2 μSv [0.1–0.2 μSv] for radiography.
Conclusions
CBCT provides advantages for the evaluation of acute small bone and joint trauma by detecting and excluding extremity fractures and fracture-related findings more reliably than radiographs. Additional findings induced therapy change in one third of patients, suggesting substantial clinical impact.
As one kind of “smart” material, thermogelling polymers find applications in biofabrication, drug delivery and regenerative medicine. In this work, we report a thermosensitive poly(2-oxazoline)/poly(2-oxazine) based diblock copolymer comprising thermosensitive/moderately hydrophobic poly(2-N-propyl-2-oxazine) (pPrOzi) and thermosensitive/moderately hydrophilic poly(2-ethyl-2-oxazoline) (pEtOx). Hydrogels were only formed when block length exceeded certain length (≈100 repeat units). The tube inversion and rheological tests showed that the material has then a reversible sol-gel transition above 25 wt.% concentration. Rheological tests further revealed a gel strength around 3 kPa, high shear thinning property and rapid shear recovery after stress, which are highly desirable properties for extrusion based three-dimensional (3D) (bio) printing. Attributed to the rheology profile, well resolved printability and high stackability (with added laponite) was also possible. (Cryo) scanning electron microscopy exhibited a highly porous, interconnected, 3D network. The sol-state at lower temperatures (in ice bath) facilitated the homogeneous distribution of (fluorescently labelled) human adipose derived stem cells (hADSCs) in the hydrogel matrix. Post-printing live/dead assays revealed that the hADSCs encapsulated within the hydrogel remained viable (≈97%). This thermoreversible and (bio) printable hydrogel demonstrated promising properties for use in tissue engineering applications.
Objective
To evaluate changing trends in patient collectives, age-related patterns of manifestation, and diagnostic pathways of patients with extrapulmonary head and neck tuberculosis (TB), and to provide strategies to fasten diagnosis in these patients.
Study design
Case control study.
Methods
A 10-year retrospective analysis of 35 patients diagnosed with extrapulmonary TB in the head and neck at a tertiary university institution from 2009 to 2019, with special focus on the influence of the patient's age on consideration of TB and clinical patterns.
Results
The vast majority of patients younger than 40 years had their origin in countries with high TB burden (P = .0003), and TB was considered very early as a differential diagnosis (P = .0068), while most patients older than 40 years were domestic citizens initially suspected for a malignancy, who more often had an underlying immunosuppressive condition (0.0472). Most frequent manifestations in both groups were the lymph nodes, larynx, and oropharynx. Surprisingly, no differences in the rates of open TB or history of TB infection in the family anamnesis were found.
Conclusion
The two groups of patients found most often are younger patients migrating from regions with high TB burden and elderly domestic patients suffering from immunosuppressive conditions, with the latter often being misdiagnosed as malignancies. TB remains an important but difficult differential diagnosis, due to the initially unspecific symptoms and the great variety in the presentation of manifestations in the head and neck.
Objectives
To provide a detailed step-by-step operative technique, and to report on long-term functional and metabolic outcomes in secondary continence mechanisms in the form of secondary intussuscepted ileal nipple valves in revisional surgery of ileocecal pouches.
Methods
From May 1997 to May 2015, 18 female and 10 male patients suffering from dysfunctional primary continence mechanisms of their ileocecal pouch underwent revisonal surgery to create a secondary ileal nipple valve at our tertiary referral center. The average follow-up period was 65.4 months.
Results
After surgery, 24 patients were continent by day and night, and four patients showed minor incontinence with the use of a safety pad. The average frequency of clean intermittent catheterization decreased both during the day and at night. The diameter of the catheters used for clean intermittent catheterization increased significantly. No patient showed stomal stenosis, change of stool habits or metabolic situation in the follow-up period. Furthermore, the creation of the secondary ileal nipple valves did not affect the capacity of the reservoir. In the long-term follow up, two patients required the construction of a third continence mechanism, making for an overall success rate of 92% in the study group.
Conclusion
To our knowledge, this is the first study of long-term results after the creation of secondary ileal nipple valves. We provide evidence that the creation of a secondary ileal nipple valve is a safe and reliable procedure for continence restoration in ileocecal pouches with excellent functional and metabolic long-term outcomes.
Fluoride abstraction from different types of transition metal fluoride complexes [L\(_n\)MF] (M=Ti, Ni, Cu) by the Lewis acid tris(pentafluoroethyl)difluorophosphorane (C\(_2\)F\(_5\))\(_3\)PF\(_2\) to yield cationic transition metal complexes with the tris(pentafluoroethyl)trifluorophosphate counterion (FAP anion, [(C\(_2\)F\(_5\))\(_3\)PF\(_3\)]\(^-\)) is reported. (C\(_2\)F\(_5\))\(_3\)PF\(_2\) reacted with trans-[Ni(iPr\(_2\)Im)\(_2\)(Ar\(^F\))F] (iPr2Im=1,3-diisopropylimidazolin-2-ylidene; Ar\(^F\)=C\(_6\)F\(_5\), 1 a; 4-CF\(_3\)-C\(_6\)F\(_4\), 1 b; 4-C\(_6\)F\(_5\)-C\(_6\)F\(_4\), 1 c) through fluoride transfer to form the complex salts trans-[Ni(iPr\(_2\)Im)\(_2\)(solv)(Ar\(^F\))]FAP (2 a-c[solv]; solv=Et\(_2\)O, CH\(_2\)Cl\(_2\), THF) depending on the reaction medium. In the presence of stronger Lewis bases such as carbenes or PPh\(_3\), solvent coordination was suppressed and the complexes trans-[Ni(iPr\(_2\)Im)\(_2\)(PPh\(_3\))(C\(_6\)F\(_5\))]FAP (trans-2 a[PPh\(_3\)]) and cis-[Ni(iPr\(_2\)Im)\(_2\)(Dipp\(_2\)Im)(C\(_6\)F\(_5\))]FAP (cis-2 a[Dipp\(_2\)Im]) (Dipp\(_2\)Im=1,3-bis(2,6-diisopropylphenyl)imidazolin-2-ylidene) were isolated. Fluoride abstraction from [(Dipp\(_2\)Im)CuF] (3) in CH\(_2\)Cl\(_2\) or 1,2-difluorobenzene led to the isolation of [{(Dipp\(_2\)Im)Cu}\(_2\)]\(^2\)\(^+\)2 FAP\(^-\) (4). Subsequent reaction of 4 with PPh\(_3\) and different carbenes resulted in the complexes [(Dipp\(_2\)Im)Cu(LB)]FAP (5 a–e, LB=Lewis base). In the presence of C6Me6, fluoride transfer afforded [(Dipp\(_2\)Im)Cu(C\(_6\)Me\(_6\))]FAP (5 f), which serves as a source of [(Dipp\(_2\)Im)Cu)]\(^+\). Fluoride abstraction of [Cp\(_2\)TiF\(_2\)] (7) resulted in the formation of dinuclear [FCp\(_2\)Ti(μ-F)TiCp\(_2\)F]FAP (8) (Cp=η\(^5\)-C\(_5\)H\(_5\)) with one terminal fluoride ligand at each titanium atom and an additional bridging fluoride ligand.
The synthesis and characterization of Lewis acid/base adducts between tris(pentafluoroethyl)difluorophosphorane PF\(_{2}\)(C\(_{2}\)F\(_{5}\))\(_{3}\) and selected N-heterocyclic carbenes (NHCs) R\(_{2}\)Im (1,3-di-organyl-imidazolin-2-ylidene) and phosphines are reported. For NHCs with small alkyl substituents at nitrogen (R=Me, nPr, iPr) the adducts NHC ⋅ PF\(_{2}\)(C\(_{2}\)F\(_{5}\))\(_{3}\) (2 a–h) were isolated. The reaction with the sterically more demanding NHCs Dipp\(_{2}\)Im (1,3-bis-(2,6-di-iso-propylphenyl)-imidazolin-2-ylidene) (1 i) and tBu\(_{2}\)Im (1,3-di-tert-butyl-imidazolin-2-ylidene) (1 j) afforded the aNHC adducts 3 i and 3 j (a denotes “abnormal” NHC coordination via a backbone carbon atom). The use of tBuMeIm (1-tert-butyl-3-methyl-imidazolin-2-ylidene) (1 m) led to partial decomposition of the NHC and formation of the salt [tBuMeIm−H][MeIm ⋅ PF\(_{2}\)(C\(_{2}\)F\(_{5}\))\(_{3}\)] (4 m). The phosphorane PF\(_{2}\)(C\(_{2}\)F\(_{5}\))\(_{3}\) forms adducts with PMe\(_{3}\) but does not react with PPh\(_{3}\) or PCy\(_{3}\). The mer-cis isomer of literature-known Me\(_{3}\)P ⋅ PF\(_{2}\)(C\(_{2}\)F\(_{5}\))\(_{3}\) (5 a) was structurally characterized. Mixtures of the phosphorane PF\(_{2}\)(C\(_{2}\)F\(_{5}\))\(_{3}\) and the sterically encumbered NHCs tBu\(_{2}\)Im, Dipp\(_{2}\)Im, and Dipp\(_{2}\)Im\(^{H2}\) (1,3-bis-(2,6-di-iso-propylphenyl)-imidazolidin-2-ylidene) (1 k) showed properties of FLPs (Frustrated Lewis Pairs) as these mixtures were able to open the ring of THF (tetrahydrofuran) to yield NHC−(CH\(_{2}\))\(_{4}\)O−PF\(_{2}\)(C\(_{2}\)F\(_{5}\))\(_{3}\) 6 i–k. Furthermore, the deprotonation of the weak C−H acids CH\(_{3}\)CN, acetone, and ethyl acetate was achieved, which led to the formation of the corresponding imidazolium salts and the phosphates [PF\(_{2}\)(C\(_{2}\)F\(_{5}\))\(_{3}\)(CH\(_{2}\)CN)]\(^{-}\) (7), [PF\(_{2}\)(C\(_{2}\)F\(_{5}\))\(_{3}\)(OC(=CH\(_{2}\))CH\(_{3}\))]\(^{-}\) (8) and [PF\(_{2}\)(C\(_{2}\)F\(_{5}\))\(_{3}\)(CH\(_{2}\)CO\(_{2}\)Et)]\(^{-}\) (9).
Gonorrhea, a sexually transmitted disease caused by the bacteria Neisseria gonorrhoeae, is characterized by a large number of neutrophils recruited to the site of infection. Therefore, proper modeling of the N. gonorrhoeae interaction with neutrophils is very important for investigating and understanding the mechanisms that gonococci use to evade the immune response. We have used a combination of a unique human 3D tissue model together with a dynamic culture system to study neutrophil transmigration to the site of N. gonorrhoeae infection. The triple co-culture model consisted of epithelial cells (T84 human colorectal carcinoma cells), human primary dermal fibroblasts, and human umbilical vein endothelial cells on a biological scaffold (SIS). After the infection of the tissue model with N. gonorrhoeae, we introduced primary human neutrophils to the endothelial side of the model using a perfusion-based bioreactor system. By this approach, we were able to demonstrate the activation and transmigration of neutrophils across the 3D tissue model and their recruitment to the site of infection. In summary, the triple co-culture model supplemented by neutrophils represents a promising tool for investigating N. gonorrhoeae and other bacterial infections and interactions with the innate immunity cells under conditions closely resembling the native tissue environment.
Novel dyes were prepared by simple “click CuAAC” attachment of a triarylborane–alkyne to the azide side chain of an amino acid yielding triarylborane dye 1 which was conjugated with pyrene (dye 2) forming a triarylborane–pyrene FRET pair. In contrast to previous cationic triarylboranes, the novel neutral dyes interact only with proteins, while their affinity to DNA/RNA is completely abolished. Both the reference triarylborane amino acid and triarylborane–pyrene conjugate bind to BSA and the hDPP III enzyme with high affinities, exhibiting a strong (up to 100-fold) fluorescence increase, whereby the triarylborane–pyrene conjugate additionally retained FRET upon binding to the protein. Furthermore, the triarylborane dyes, upon binding to the hDPP III enzyme, did not impair its enzymatic activity under a wide range of experimental conditions, thus being the first non-covalent fluorimetric markers for hDPP III, also applicable during enzymatic reactions with hDPP III substrates.
Background: Selective outcome reporting in clinical trials introduces bias in the body of evidence distorting clinical decision making. Trial registration aims to prevent this bias and is suggested by the International Committee of Medical Journal Editors (ICMJE) since 2004.
Methods: The 585 randomized controlled trials (RCTs) published between 1965 and 2017 that were included in a recently published Cochrane review on antiemetic drugs for prevention of postoperative nausea and vomiting were selected. In a retrospective study, we assessed trial registration and selective outcome reporting by comparing study publications with their registered protocols according to the ‘Cochrane Risk of bias’ assessment tool 1.0.
Results: In the Cochrane review, the first study which referred to a registered trial protocol was published in 2004. Of all 585 trials included in the Cochrane review, 334 RCTs were published in 2004 or later, of which only 22% (75/334) were registered. Among the registered trials, 36% (27/75) were pro- and 64% (48/75) were retrospectively registered. 41% (11/27) of the prospectively registered trials were free of selective outcome reporting bias, 22% (6/27) were incompletely registered and assessed as unclear risk, and 37% (10/27) were assessed as high risk. Major outcome discrepancies between registered and published high risk trials were a change from the registered primary to a published secondary outcome (32%), a new primary outcome (26%), and different outcome assessment times (26%). Among trials with high risk of selective outcome reporting 80% favoured at least one statistically significant result. Registered trials were assessed more often as ‘overall low risk of bias’ compared to non-registered trials (64% vs 28%).
Conclusions: In 2017, 13 years after the ICMJE declared prospective protocol registration a necessity for reliable clinical studies, the frequency and quality of trial registration in the field of PONV is very poor. Selective outcome reporting reduces trustworthiness in findings of clinical trials. Investigators and clinicians should be aware that only following a properly registered protocol and transparently reporting of predefined outcomes, regardless of the direction and significance of the result, will ultimately strengthen the body of evidence in the field of PONV research in the future.